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    Carbocisteine Drug Study

    Uploaded by

    Ed King Cubalan
    Assignment in Pharmacology for dry cough

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    © All Rights Reserved
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    Carbocisteine Drug Study

    Uploaded by

    Ed King Cubalan
    37 views3 pages
    Assignment in Pharmacology for dry cough

    Copyright

    © © All Rights Reserved

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    DOCX, PDF, TXT or read online from Scribd

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    Assignment in Pharmacology for dry cough

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    37 views3 pages

    Carbocisteine Drug Study

    Uploaded by

    Ed King Cubalan
    Assignment in Pharmacology for dry cough

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 3

    Carbocisteine Drug Study

    Generic Name:

    Carbocisteine (also known as Carbocysteine)

    Brand Names:

    Mucodyne, Mucolyn, Solmux

    Drug Classification:

     Mucolytic agent

    Mechanism of Action:

    Carbocisteine works by breaking down and thinning mucus in the airways, making it easier to cough up
    and clear from the respiratory tract. It reduces the viscosity of mucus by breaking the disulfide bonds in
    the mucoproteins, which facilitates expectoration and improves breathing.

    Indications:

    Carbocisteine is used to treat respiratory conditions characterized by excessive or thickened mucus,


    including:

     Chronic obstructive pulmonary disease (COPD)

     Chronic bronchitis

     Asthma

     Sinusitis

     Otitis media with effusion (glue ear)

    Dosage and Administration:

    Adults:

     Typical dosage is 375 mg three times a day. The dose may be adjusted based on the severity of
    symptoms.

    Pediatrics:

     The dosage for children is usually based on their weight and age. It is typically given as a syrup:

    o Children aged 2-5 years: 62.5 mg (2.5 ml of 250 mg/5 ml syrup) three times a day.

    o Children aged 6-12 years: 125 mg (5 ml of 250 mg/5 ml syrup) three times a day.

    Pharmacokinetics:

     Absorption: Rapidly absorbed from the gastrointestinal tract.

     Distribution: Widely distributed in body tissues.


     Metabolism: Metabolized in the liver.

     Excretion: Excreted mainly via the urine. The half-life is approximately 1.5 hours.

    Side Effects:

    Common side effects may include:

     Gastrointestinal discomfort (nausea, vomiting, diarrhea)

     Rash

     Headache

    Serious side effects, though rare, may include:

     Allergic reactions (e.g., rash, itching, swelling, severe dizziness, trouble breathing)

     Gastrointestinal bleeding

    Contraindications:

     Known hypersensitivity to carbocisteine or any of its components

     Active peptic ulcer

    Precautions:

     Use with caution in patients with a history of peptic ulcer disease, as carbocisteine can cause
    gastrointestinal irritation.

     Caution is advised in patients with renal impairment, as dosage adjustment may be necessary.

    Interactions:

     Antitussives (cough suppressants): May counteract the effect of carbocisteine by suppressing


    the cough reflex, making it difficult to expel the mucus.

     Other mucolytics: Concurrent use may increase the risk of gastrointestinal side effects.

    Monitoring:

     Monitor for signs of gastrointestinal discomfort or bleeding.

     Assess the effectiveness in terms of reduction in mucus viscosity and ease of expectoration.

    Patient Education:

     Take carbocisteine exactly as prescribed, and do not exceed the recommended dose.

     Drink plenty of fluids to help loosen mucus and improve the effectiveness of the medication.

     Avoid taking cough suppressants while using carbocisteine unless directed by a healthcare
    provider.
     Report any severe or persistent side effects, especially gastrointestinal issues, to your healthcare
    provider.

     Inform your healthcare provider of any other medications you are taking, including over-the-
    counter drugs and supplements.

    Conclusion:

    Carbocisteine is an effective mucolytic agent that helps in the management of respiratory conditions
    with excessive or thickened mucus. While generally well-tolerated, patients should adhere to the
    prescribed dosage and be aware of potential side effects and interactions. Proper patient education and
    monitoring are essential to ensure safe and effective use of this medication.

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