Biopotential Multi-Path Current Feedback Instrumentation Amplifier With Automatic Offset Cancellation Loop For Resistive Bridge Microsensors
Biopotential Multi-Path Current Feedback Instrumentation Amplifier With Automatic Offset Cancellation Loop For Resistive Bridge Microsensors
Corresponding Author:
Younes Laababid
Laboratory of Computer Science and Interdisciplinary Physics (LIPI)
Normal Superior School Fez (ENSF), Sidi Mohamed Ben Abdellah University Laboratory
Fez, Morocco
Email: [email protected]
1. INTRODUCTION
Micro-electro-mechanical systems (MEMS) technology is currently gaining significant attention due
to the inherent advantages of miniaturization, high signal-to-noise ratio (SNR), and affordability, which has led
to its ubiquitous application across a plethora of sensing devices [1]. Among these, resistive MEMS sensors
stand out, offering a unique combination of structural simplicity, superior linearity, and robust durability, making
them an optimal choice for the detection of various data, including but not limited to biological signals [2]–[6].
Additionally, MEMS resistive sensors require a change to detect an amount of physical change. This
resistive change converts to a low amplitude voltage [7], [8]. For this reason, a good use for MEMS resistive
bridge sensors in electromyogram (EMG), electrocardiogram (ECG) and electroencephalogram (EEG) bio-
potential signals, is an instrumentation amplifier with high precision signal processing low noise thanks to its
high gain and CMRR also, thus eliminating offset voltages by an automatic offset cancellation circuit [9].
The amplitude of biopotential signals typically lies within a minute range of about 5 µV to 20 mV,
and these signals operate within the frequency domain of 0 Hz to 1 kHz [10]. As such, the main objective in
designing an instrumentation amplifier for these signals is to prioritize the achievement of low noise, minimal
power usage, and enhanced input impedance [11]. When it comes to quantifying energy efficiency and
evaluating the trade-off between power consumption and noise in biomedical devices, the Noise efficiency
factor (NEF) often serves as the standard measure [12]. It is calculated as in (1).
2𝐼ₜₒₜ
𝑁𝐸𝐹 = 𝑉ₙᵢ͵ᵣₘₛ √ (1)
𝜋.𝑈ᴛ.4𝐾𝑇.𝐵𝑊
Where Vₙᵢ͵ᵣₘₛ is the input referred noise voltage (IRN), Iₜₒₜ is the current, Uᴛ is the thermal voltage, k is
Boltzmann’s constant, T is the temperature in Kelvins (body temperature =300 K), and BW is the bandwidth
of the system in Hz.
The capacitively coupled instrumentation amplifier (CCIA) plays a significant role in precise
biopotential measurements. Its purpose is to eradicate DC offset at the electrode-skin interface, effectively
blocking undesired potential signals. However, it's worth noting that the CCIA's input impedance is adversely
affected by its input capacitance, which results in a lower impedance. As the chopper's frequency escalates,
this problem can trigger a decrease in signal amplitude and a reduction in the common-mode rejection ratio
(CMRR), consequently influencing measurement precision [13]. A noteworthy correlation can be drawn
between the input capacitance of the CCIA and the input impedance.
2
𝑍ᵢₙ(𝐶𝐶𝐼𝐴) = (2)
𝑠𝐶𝑖𝑛
Figure 1 shows the tripartite structure of the CFIA's amplification stages. The overall amplification of the CFIA
is shown as (4).
𝐺𝑚1 𝑅2
𝐺𝐶𝐹𝐼𝐴 ≈ (1 + 2 ) (4)
𝐺𝑚2 𝑅1
Trans conductors Gm1 and Gm2 serve the crucial role of converting the input voltage and the feedback
voltage to currents in a complementary fashion. A noteworthy prerequisite for attaining substantial and accurate
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amplification necessitates the matching of Gm1 and Gm2, as stipulated in [16]. Techniques aimed at reducing
noise are vital in fabricating a neural signal amplifier, having the potential to curb the flicker noise that leads
to a decrease in biopotential signals emanating from resistive bridges. Two notable strategies-chopper
stabilization (CHS) and automatic zeroing (AZ) - have been identified as effective means to attenuate the
impact of noise density and DC offset in the baseband, as referenced in [17].
In our research, we introduce a unique analog front-end (AFE) configuration, specifically designed
for resistive bridge microsensors. The emphasis in this proposed AFE is on minimal power consumption and
noise reduction, achieved by incorporating a chopper-stabilized multipath current-feedback class-AB CFIA
and an automatic offset cancellation loop developed. The CFIA applies chopper stabilization methods to
effectively reduce offset and 1/f noise. Additionally, the incorporation of a ripple reduction loop (RRL) aims
to diminish output ripple. To evaluate the AFE's performance, we built and simulated it using a 180 nm CMOS
technology framework and powered it with a 1.8V power supply.
The rest of the parts of the paper are organized as follows: i) Section 2 gives an overview of the
resistive bridge AFE design as well as the architecture and sub-blocks; ii) Simulation results and comparisons
are described in section 3; and iii) Finally, the conclusion and upcoming work are discussed in section 4.
At the DC operating point, Gm11 = Gm21 = 156 μA/V and Cm51 = 49 pF, so the UGBW is 506 kHz.
The LFP consists of five stages this is why its gain is very large compared to the gain of HFP, to obtain an
offset-stabilized for the latter which has a residual offset at the input (Gm11). According to (6), we need to
strengthen the LFP's gain in order to remove the HFP's offset, therefore Gm3 is designed as a gain-boosted
single-stage folded-cascode OTA to reinforce the DC gain and bring down the HFP's offset to 1 µV [15]. The
residual input offset can be expressed as (6) [20].
𝐺𝐻𝐹𝑃
𝑉𝑜𝑓𝑓𝑠𝑒𝑡 ≈ 𝑉𝑜𝑠, ᵢₙ (6)
𝐺𝐿𝐹𝑃
Vos,ᵢₙ here refers to the offset of Gm11. Internal offset stabilization is achieved by transmuting the
offset voltage Vos21 into a current, denoted Ios21, at the output of Gm21. This current, once rippled by CH3
modulation, is transformed into a triangle-wave voltage, symbolized by (V), via a Miller integrator (Gm3).
Interestingly, the ripple at the output of Gm3 can be represented as (7).
𝑉𝑜𝑠21.𝐺ₘ₂₁ 𝐼𝑜𝑠21
𝑉𝑅𝑖𝑝𝑝𝑙𝑒 ≈ ≈ (7)
2𝑓𝑐ℎ𝑜𝑝.𝐶ₘ₃₁ 2𝑓𝑐ℎ𝑜𝑝.𝐶ₘ₃₁
The ripple voltage at Gm3's output will be integrated once again by Gm5 as a sinusoidal ripple at the CFIA's
output, and its amplitude may then approximately be estimated using (8).
𝐺ₘ₄
𝑉𝑅𝑖𝑝𝑝𝑙𝑒, 𝑜𝑢𝑡 ≈ 𝑉𝑅𝑖𝑝𝑝𝑙𝑒 (8)
8𝑓𝑐ℎ𝑜𝑝.𝐶ₘ₅₁
The high frequency ripple of the converted voltage generated at the output of Gm3 is sensed,
demodulated and converted into a compensation current by the RRL with good impact, which consists of an
input AC coupling capacitors Cs, a current buffer (CB), a CLPF capacitor to mitigate the RRL's second-harmonic
ripple when using with output impedance of a current buffer (CB), and a transconductance Gm6. The ripple
voltage is transformed by Cs into the current IR, which CH4 then demodulates into DC. The current at the input
of CB is given by (9).
As a result, the current, referred to as IR, at the CB's output can be estimated as presented in (10).
Here, VCB signifies the output voltage of CB, RCB stands for the DC output impedance of CB, and ACB
represents the DC voltage gain of the NMOS cascode in CB.
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𝑉𝐶𝐵 𝑉𝐶𝐵.2𝑓𝑐ℎ𝑜𝑝.𝐶ₛ
|𝐼𝑅| ≈ ≈ (10)
𝑅𝐶𝐵 𝐴𝐶𝐵
Accordingly, to enhance ripple suppression, the CB is mounted as a gain-boosted Current Buffer. The
two output currents of Gm21 and Gm22 merge with the output current of Gm6 (ripple) in (11) to return
negatively to the input of CH3.
𝑉𝑜𝑠21.𝐺ₘ₂₁.𝐴𝐶𝐵.𝐺ₘ₆ 𝐼𝑜𝑠21.𝐴𝐶𝐵.𝐺ₘ₆
𝐼𝑅𝑅𝐿 ≈ ≈ (11)
2𝑓𝑐ℎ𝑜𝑝.𝐶ₘ₃₁ 2𝑓𝑐ℎ𝑜𝑝.𝐶ₘ₃₁
The voltage without ripple is transformed to a current through Gm4 and is mixed with the HFP
currents and integrated through Gm5. As a result, the ripple is reduced more effectively. The design of current
buffer (CB) with in RRL [15] is shown in Figure 4.
The suggested block diagram of the CFIA circuit with feedback can be seen in Figure 5, which is
adopted an AC-coupled capacitive feedback network with a parallel pseudo- resistor, in hopes of reducing the
chip area and give the low-frequency attenuation properties. We may create a high-pass transfer function using
the capacitive feedback [21]. The transfer function of the CFIA can be expressed as (12) without the
compensation voltage of DAC.
1+𝑠𝑅𝐹.(𝐶𝐹₁+2𝐶𝐹₂) 𝐶𝐹₂
𝐺𝐶𝐹𝐼𝐴 ≈ ≈1+2 (12)
1+𝑠𝐶𝐹₁.𝑅𝐹 𝐶𝐹₁
Figure 4. Current buffer design Figure 5. Block diagram of the CFIA circuit with feedback
The SPI enables gain adjustments via a 5-bit programmable weighted capacitor array, CF1, facilitated
by controlling each switch within the capacitor array. The range for this programmable gain spans from 20 dB
(00000) to 55 dB (11111). The multipath CFIA utilizes a chopping frequency of 75 kHz, synchronized with
the non-overlapping clocks.
The detailed representation of the HFP within the suggested CFIA is provided in Figure 6(a). This
configuration includes a class-AB output stage, Gm5, along with non-chopped input trans conductors Gm11 and
Gm12. The currents transitioned via the trans conductors stages Gm11, Gm12, and Gm4, are combined by an
active Miller-compensated class-AB output stage Gm5 [22]. At the Gm5 juncture, the class-AB biasing and
elevation of power efficiency is executed through a Monticelli-style floating setup using MP14, MN5, MP15, and
MN6. Notably, this Monticelli style is also crucial in curbing signal distortion [23]. The addition of an error
amplifier CMFB circuit in the HFP assists in managing the bias current of the cascode stages, thereby ensuring a
higher differential output range with minimal power consumption [24]. Figure 6(b) showcases the CMFB. To
compensate for the frequency response within the HFP, a nested Miller compensation technique is employed [25].
It's important to note that the input referred noise (IRN) of the CFIA is predominantly influenced by
the LFP and input stage of the HFP. The IRN dominated by the HFP's input stage, inclusive of thermal and
flicker noise components, can be approximated as (13).
Where 𝜇 is the effective mobility of the MOSFET, f is the signal frequency, KF is the process-dependent flicker
noise coefficient of MOSFET, Cox is the gate-oxide capacitance of M1,2 and K is the Boltzmann constant. At
low frequencies, the thermal noise of the LFP’s input stage is dominated, is calculated as (14).
𝛾4𝐾𝑇 𝛾4𝐾𝑇
𝑉²n, th ≈ 2. [ + ] (14)
𝐺ₘ₂₁ 𝐺ₘ₂₂
(a) (b)
Figure 6. Schematic of the HFP circuit: (a) the high-frequency path in CFIA and (b) the CMFB circuit
A Dynamic Comparator was employed in our design, which makes use of a StrongARM latch
architecture, to evaluate the amplified bridge offset at the CFIA output node. The StrongARM latch structure, as
represented in Figure 8, shows power efficiency and reduced offset. This design includes a differential pair input,
two sets of cross-coupled transistors M3-M6, four clocked PMOS switches S1-S4, and an SR-latch. The SR-latch
is responsible for latching the differential outputs and generating VCOMP_OUT. The offset impact of transistors
M3-M6 is reduced by deactivating them initially through the pre-charging operation of PMOS switches S1 to
S4 [28]. This feature provides the StrongArm architecture with increased offset compensation resilience.
Within the AOCL, the 12-Bit SAR control logic is organized around two sequences of edge-triggered
D flip-flops, which sequentially determine each bit. Each D flip-flop is engineered with a transmission gate
(TG) and inverters. The first sequence of flip-flops operates as a shift register, receiving data from the
comparator. On the other hand, the second sequence of flip-flops functions as a data storage module, with the
responsibility of generating the DAC control input, as shown in Figure 9 [29].
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Figure 9. Layout of the 12-bit SAR control logic within the AOCL
Figure 10. Visual representation of the R-2R DAC's structure within the AOCL
Initially, the SAR is reset, positioning the most significant bit (MSB) of the DAC input at '1', while
setting the least significant bit (LSB) bits to '0'. As the comparator evaluates the output offset, VCOMP_OUT
progressively modifies the state of MSB and LSB. The end of conversion (EOC) flag is set high (H) upon
Biopotential multi-path current feedback instrumentation amplifier with … (Younes Laababid)
2114 ISSN: 2088-8694
completion of offset compensation, signifying the end of the AOCL operation. A capacitor (Cv) is integrated
at the output of the DAC to expedite the calibration time for the AOCL operation.
The layout of the R-2R DAC circuit is presented in Figure 10. We employ an R-2R ladder network to
enhance precision, albeit at the expense of increased area requirements. The resistors are linked either to a high
voltage or to the ground, mediated by a transmission gate. This gate amalgamates a PMOS and an NMOS, with
their gates connected to the incoming voltage and their drains merged at a common node. A particular challenge
that arises in designing an R-2R DAC is maintaining monotonicity [30]. This is manifested when an increase
in the input could potentially result in a decrease in the output. One approach to mitigate this issue involves
minimizing the resistance of the transmission gate, achieved by widening it to facilitate smoother current flow
within the circuit.
Figure 11. Transfer function of the CFIA Figure 12. AC Programmable transfer function gain
simulation results of CFIA
Figure 13. CMRR simulation results Figure 14. PSRR simulation results
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Figure 17 displays the simulation results of the automatic offset calibration loop process. The blue
curve represents the 1 kHz AOCL clock, the golden line depicts the end-of-conversion (EOC) output from the
AOCL, and the red and yellow curves show the differential output of the CFIA. The differential input signals
harbor a 250-mV offset. Once the AOCL operation begins, the initial offset is quickly corrected. In the absence
of the acceleration capacitor Cv, the offset calibration time amounts to 11 ms. However, when Cv is
implemented, it can be seen that the offset calibration time for the AOCL operation drops to 5 ms, as illustrated
in Figure 18.
Output (V)
Output (V)
Figure 17. Measurement result of AOCL process Figure 18. Measurement result of AOCL process
without Cv with Cv
The performance comparisons between the proposed CFIA and many state-of-the-art IAs are
summarized in Table 1. It may be deduced from [14], [18], [33], [34] that the recommended CFIA exhibits a
good input-referred offset. It is possible to conclude that the suggested CFIA has better CMRR to reject the
power-line interference at the output of CFIA. Although it may be noted that our circuit can operate over a
better bandwidth with an important adjustment of the capacitor value while keeping a low power dissipation.
Figure 19. Monte-Carlo simulation results of the Figure 20. Simulation results CFIA output DC
input referred offset voltage operating point
4. CONCLUSION
This study presents the development of an analog front-end (AFE) suitable for resistive bridge
microsensors, created utilizing a 0.18 µm CMOS process. The system functions on a chopper-stabilized multi-
path framework, consuming a total current of 162 μA at a supply voltage of 1.8 V. The readout circuit
comprises components such as a multi-path CFIA, AOCL, 2nd-order LPF, a 12-bit SAR ADC, a buffer, and
an SPI block. The multi-path structure effectively eliminates the notches caused by the RRL, while the ripple
resulting from chopper up-modulation is mitigated through the use of an RRL scheme in the LFP. The proposed
circuit, by counteracting the offsets in the bridge, can facilitate low-noise performance. The AOCL component
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serves to neutralize the undesired offset instigated by the resistive bridge sensor through the application of a
binary search algorithm. The multi-path CFIA is capable of amplifying faint signals, boasting a gain of
50.77 dB, a CMRR of 114 dB, and a PSRR of 103 dB. The system accomplishes an input-referred offset of
0.9 μV and an input-referred noise at 200 Hz measuring 16 ηV/√Hz, thereby decreasing the noise efficiency
factor (NEF) to 5.18. The total power consumption registers at 291 μW, demonstrating low-power traits. Given
its effective input-referred offset and minimal power consumption, the developed AFE proves to be an ideal
candidate for a multitude of resistive-bridge sensor applications.
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BIOGRAPHIES OF AUTHORS
Karim El Khadiri received M.S. and Ph.D. degrees in Faculty of Sciences from
Sidi Mohammed Ben Abdellah University in 2011 and 2017, respectively. Since 2012, he
served as a Research Scientist at Faculty of science in the University of Sidi Mohammed Ben
Abdellah, Fez, Morocco and guest researcher at LIMA laboratory in UQO Canada. His
current interests include switch mode audio amplifier, CMOS mixed-mode integrated circuit
design, design techniques for RFID, RF front-ends for passive tags, Li-Ion battery charger
and power management. He can be contacted at email: [email protected].
Ahmed Tahiri received the graduate degree DES in Department of Physics, Sidi
Mohammed Ben Abdellah University, Morocco in 1997, received the Ph.D. degree in physics
from the University Sidi Mohamed Ben Abdellah, Faculty of Science, Morocco in 2005. He
completed his doctoral studies in didactics of science in the University of Sherbrooke in
Canada in 2010. He is now a professor in Superior Normal School, ENS-FEZ, Morocco. His
research interests include image processing, computer science and didactics of scientific
disciplines. He can be contacted at email: [email protected].
Int J Pow Elec & Dri Syst, Vol. 14, No. 4, December 2023: 2107-2118