Level 4 COC

1. A1O years old boy who was taking anti-epilepic drug developed on
over growth of gum tissue (gingivaitis)
A. Phenytoin
b. Ethosuximide
C. Clonazepam
D.Carbamazepine
2. due to Ototoxicity and nephratoxicily usually occurs du to
A. Azithromicin
B. Chloramphenicol
C. Amoxicillin
D. Streptomycin
3. Which one of the following product is easily remove on the skin by
rinse water?
A.shampoo
B. Dyes
C. Conditioners
D. Cold cream
4. Which preparation has high concentration of Sugar?
A syrup
B. Elixir
C. Sprit
D. all
5. ldentify the non hormonal contraceptive methods
A. Combined oral contraceptive
B. IUCD
C. Levegestron only
D. none
6. Which one study about dosage form/
A. pharmaceutics
B. pharmacology
C. physical pharmacy
D. none
7. The continue process of drug reciving, storing and stock control..
A. Procurement
B. Distribution
C. Selection
D. none
8. Which drug need to store in refrigerator?
A. Insulin
B. Diclofenac
C. Amitryptiline
D. none
9. Which one of the following is homogenous phase?
A. solution
B. suspension
C. ointment
D. creams
9. semisolid preparation which contain more powder
A. Ointmen
B.cream
C.paste
D. none
10. A suppository which is inserted to the vaginal is known as
A. Rectal suppository
B. Pessaries
C. enemas
D. all
11.vagina agent preparation
A. Enemas
B. Douches
C. pessaries
D. none
12. Which one is False about o/w emulsion
A. External phase is water
B. Internal phase is oil
C. can conduct electricity
D. Greasy by nature
13.True about Pharmaceutical sprit,EXCEPT
A. Sweetening agent
B. Aromatic water
C. contain alcohol and volatile oil
D. pharmaceutical aid solution
14.Which is the rule of DTC in hospital?
A. Selection of drugs
B. Disposing of drugs
C. Editing hospital formulary
D. all
15. In the treatment of gastric ulcer, It. is a milestone to identify
presence of
A. Escherichia coli
B. Giardia lamblia
C .Homophiles influenza
D. Helicobacter pylori
16. 48 year old male is diagnosed with tuberculosis and has been
treated for 2 months will isoniazid and p parasthesias in the
extremities. What will you most likely do next?
A. Add pyridoxine
B. Stop isoniazid
C. Replace Isoniazide with streptomycin
D. Add vitaman E
17. The methods Of extraction sulable for heat sensitive plant
constituents is
A. Decoction
B. Soxhlet
C. Percolation
D. Refluxing
18. Who is the most appropriate person by professio that can code
drugs adapt the
A. Nurse/Health office
B. Pharmacy professional
C. Pharmacy accountant
D. Laboratory Technologist
19. Cavulinc acdis combined with amoxicillin because
A. it reduces renal clearance of amoXICillin
B. It counteracts the adverse effects of amoxicillin
C. It kills bacteria that are not killed by-amoxicilin
D. It inhibits beta lactamases that destroy amoXICIlliN
20. Hypertensive patient should be advised for possible occurrence Dry
cough when dispensing
A. Candesartan
B. irbesatan
C. Dextromethorpha
D. Enalapril
21. Which one is the leading cause of maternal death in Ethiopia
A. Obstructed labour
B.Abortion
C. Sepsis
D. Hemorrhage
22. Which of the following is the major problen with the loop diuretics
A. decrease of uric acid
B. hyperkałenmia
C. Glucose intolerance
23. Tetracychine is avoided in pregnancy because it can
A. Affect the bones and teeth of the fetus
B. Cause excessive vomiting in the mothe
C. Cause abortions
D. Cause excessive postpartum hemorrhage
24. pyridoxine gven to a patient of tuberculosis prevents
A. Ethambutol induced visual defects
B. Rifampicin induced hepatotoxicity
C. Sreptomycin induced nephrotoxicity
D. Isoniazid induced peripheral neuropathy
25. An 16 years old girl came to your health institution for advice after
a rape attack by a known HlV positve man. What do you ....to this case?
A. To start ART treatment immediately after consulting a physician
B. To take co-trimoxazole for opportunistic infection
C. To wait for her CD4 count to reach below 200 to start ARV treatment
D. To take post exposure prophylaxis after consulting a physician
26. Highiy controlled narcotic drug:
A. Phenobarbitone
B. Phenytoin
C. Pethidine
d. Cimetidine
27. Which of the following drugs are bacterostatic & bactericidal
respectively
A. Claitromycine & Erytromycin
B. Tetracycline & Erytromycine
C. Erytromycine & Claritromycine
D. Erytromycine & Tetracycline
28. Development of vaccines for diseases caused by viruses is
commonly difficult mainly duo to:
A. Very rapid mutation on viral genetic materials
B. Cold storage condition of vaccine
C. Very small size of viruses
D. Shortage of exipients for manufacturing of vaccines
29. Know a time covid-19 is highly spread in our world due to?
A. Its transmission rate is high
B. Its replication is RNA in to DNA
C. Its property is change in every minuets
30. Which of the following tissue has the greatest capacity to
biotransformation of Drugs
A. Brain
B. Liver
C. Kidney
D. Lung
31. Calculate the total quantly ol predinsolone needed for the asmathic
patients based on the prescribed schedule below Prendinsolone 40mg
BD for 5 day, then 30mg BID for 5 days, 20mg QOD for 5days then 10
mg QD for 7 days. If the avalable dose of prendisolone is 5mg. Calculate
totai predinsolone for 22 days.
A. 87
B. 348
C. 174
d. 268

32. Gentamycin is well known for its prominent side effect of

A. Hepatotoxicity
B. Ototoxicity
C. Neurotoxicity
D. Bone marrow depression
33. Information about remaining balance of stock on hand can be
obtained from:
A. BIN Card
B.Store Requisition Form
C. Goods Receiving Note
D. Store Issue Voucher
34. The route of drug administration that will give the most rapid onset
of action is
A. Intravenous injection
B. Intradermal injection
C. Subcutaneous injection
D.Intramuscular injection
35. One of the following is not true about drug distribution pattern
A. Some low molecular compounds are uniformly distributed
thorough out the body water
B. The drug may remain largely within the vascular system
C. Most drugs exhibit uniform distribution in the body
D. A few drugs are concentrated specifically in one or more tissue
36. Continually updates inventory records and accounts for additions
and subtractions when inventory item are ..... moved from one location
to another, picked from inventory, and scrapped.
A. Radio Frequency ldentification (RFID) Inventory Systems
B. Periodic Inventory System
C. Perpetual Inventory System
D. Barcode Inventory Systems
37. W/ro Yeshi with type 1 diabetic mellitus came to health facility
ambulatory patient. The physician admit her with keto acidosis. he
possible IV infusion administered is
A.5% Dextrose
B. Ringer lactates
C. bo Dextrose &0.9% NaCl
D. 0.9% Naci
38. Which of the following drug increases its absorption when taken
with fatty meal
A. Claritromycine
B. Niclosamide
C. Ketoconazole
D. Grisofulvine
39. To decrease Gl absorption of toxins we should immediately
A. Make Gl surgery
B. Put the patient on hemodialysis
C. Give activated charcoal
D. Give milk
40. Opioids are used as all of the following except
A. Antitussive
B. Anti-inflammatory
C.Anti-diarrheal agent
D. Analgesics
41. If a hospital has an aneual total consumption of Carbamazepine
syrup of 1000 bottles, what is the average monthly consumption
stocked out for 61 days in the review perod?
AMC=TC/RM-DOS/30.5
=1000/12-61/30.5
=1000/12-2
=1000/10 ..
=100bottles

A. 100 bottles
B. 83 bottles
C. 60 bottles
D 70 botties
41. Which one is an example of non- sterile preparation?
A. Syrup preparation
B. Contraceptive Implants
C. IV fluids
D. Eye drops solution
42. Schistosomasis is a disease that can affect sub -Saharan country.
This species can be treated by
A. Mebendazole
B. Albendazole
C. Praziquantel
D. Niclosamide
43. which one of the foliowing indicates a selective serotonine reuplake
inhibitor antidepressant drug?
A. Phenobarbitone
B. Diazepam
C. Fluoxetine
D. Amitriptyline
44. Why local anesthetics frequently administered in combination with
Adrenaline?
A. To delay systemic absorption of the anesthetic
B. To decrease metabolic degradation of the anesthetic
C. To enhance systemic absorption of the anesthetic
D. To decrease the hypersensitivity reactions of the anesthetic
45. ...............is not advantage of small-scale enterprise
A. Potential for large employment
B. Requirement of less capital
C. Use of domestic resources
D.High cost of production
46. Suppose there is no Doxycycline capsule in stock and 2000 are back
ordered to lower level facilities. There is one outstanding order to the
supplies for 3000capsules. The lead time for this supplier is two month
the average monthly consumption is 1000, safety stock 2000 and
procurement period six months. How much capsules should be
ordered?QO=AMC×(LT+PP)+SS-(Si+So)=1000×8+(2×1000)-
(2000+3000)=5000
A. 7000
B. 5000
C. 11000
D. 9000
47. It is not a main factors contributing for the success of micro and
small business
A. Focus on Service
B. Minimize Overhead cost
C. Maximize Overhead cost
D.Planning
48. Which of the following agents is used for the treatment of
amenorrho and hirsutism?
A. progesterone
B. testositerone
C. oxytocin
D. estrogen
49. Which one of the following statement is correct?
A. Antigens are substances formed in the body in response to
stimulation by antibodies
B. Antibodies are substances which stimulate the body to produce
antigen
C. Antibodies are substances formed in the body in response to
stimulation by antigens
D.None
50. A satisfactory suppository base must meet all of the following
Criteria Except
A. It should be inert
B. It Should Have a narrow Melting range
C. It Should melt below 30°C
D. It should be non irnitating and non sensitizing
51. Suppose you are working in Yeka health center pharmacy. Your max
stock for zidovudine 300mg for four month is 80boxes. During stock
assessment, stock taking shows 9 boxes of zidovudine and you are left
with 20days before the end of the reporting period. What will you do?
A I will order 71 boxes
B. I will order 31 bOxes
C. I will order 13 boxes
D. I will not order
52. The transdermal drug delivery system has the following advantage.
except?
A. Patient compliance is improved
B. Duration of action decreased
C. Effect on the liver are eliminated
D. Side effects are reduced
53. The rate of Drug bioavailability is Most rapid When the Drug is
formulated as
A. Controlled released product
B. Compressed Tablet
C. Hard gelatin capsul
D. Solution
54. Of the following one is over the counter drug
A. Co trimoxazole
B. Sulbutamol aerosole
C.Tetracycline
D. Acetyl salicylic acid
55. Which Types of quality control locuses on making sure the
processes are functioning correctly?
A. Process protocol
B. Control charts
C. Process control
D. Acceptance sampling
56. o lor work-out and work perf
A. Assisting in assembling and disassembling process
B. Monitoringon and testing
C. Assist noing in planning and implementing of quality assurance
procedure
56. Pareto principle(20/80) is similar with drug classification of
A. ABC classification
B. Pharmacological classification
C. Dosage form classification
D. Therapeutic classification
57. Which of the following may prescription on attack of open-angle
ginue
A. Physostigmine
B. Atropine.
C. Pilocarpine
D. Echothiophate
58. A bronchial smooth muscle Contains
A. Alfa 1 receptors
B. Alfa 2 receptors
C. Beta 1 receptors
D. Beta 2 receptors
59. The drug of choice for manic-depressive psychosis is
A. Imipramine
B. Chlordiazepoxide
C. Isocarboxide
D. Lithium carbonate
60. Which of the following syrmpatiomimetics is preferable for üihe
eme
Shock & heart failure?
A. Epinephrine
B. Dobutamine
C. Isoproterenol
D. Methoxanuine
61. Which drug is the least potent diuretie'
A. Osmotic diuretics
B. Loop diuretics
C Thinzide diureties
D. Amilanide
62.A skill very important in teamwork for team building
A. Driving skill
B. Selling skill
C. Presentation skill
D. Communication skill
63. Information about remaining balance of stock on hand can be
obtained from
A. Store issue voucher
B. BIN card
C. Store requisition form
D. Goods receiving note
64. The technical name for the time period from placing order to
receiving the products is;
A. Lead time
B. Review period
C. Ordering time
D. Waiting time
65. Provision of technical, KAIZEN and enterpreneunal skill support
needs more in;
A. Micro, small and medium enterprises
B. Research centers
C. Universities
D. Corporate companies
66. Training should be organized with a purpose to;
A. Use allocated budget before year end
B. Reward best performing individuals
C. Entertain team members away from work place
D. Develop low performing individuals
67. Which one of the following is not basic function of skin cosmetics?
A. Beauty the skin
B. Delivery of systemic drugs
C. Masking scars
D. Cleaning the skin
68. What kind of drug need not necessary be stocked at emergency
room?
A. Antidote drugs
B. Opioid analgesics
C. Vasopression drugs
D. Vitamines
69. It is not a main factors contributing for the success of micro and
small business
A. Focus on service
B. Planning
C. Minimize overhead cost
D. Maximize overhead cost
70. A 48 year old is diagnosed with tuberculosis and has been treated
for 2 months will isoniazide and Rifampicin with good response, but
that patient develops numbness and parenthesis in the extremities.
What will you most likely do next?
A. Add pyridoxine
B. Add vitamin E
C. Stop isoniazide
D. Replace isoniazide with streptomycin
71. Among the acid lowering drugs, gynacomastia is side effect related
with;
A. Cimetidine
 B. Magnesium hydroxide
C. Omeprazole
D. Esomeprazole
72. One is not a plant with medicinal effect;
A. Tinea capitis
B. Atropa belladonna
C. Opium poppy
D. Digitalis purpurea
73. Which medication is first line treatment for type 1 diabetes and
also can be used to treat uncontrolled type 2 diabetes?
A. Insulin
B. Glimepride
C. Mettformin
D. Glibenclamide
84. Tinnitus is a common side effect of;
A. Cloroquine
B. Mefloquine
C. Quinine
D. Primaquine
85. PPF 400,000ml bid fo 7 days. How many vials should be
dispensed for this you have in stock si 4000,000iu?
A. 2 vial
B. 4 vial 400,000×2×7=5,600,000/4,000,000
C. 1 vial =1.4~2vial
D. 3 vial

86. How can you establish quality specification for work out and work
performance?
A. Assisting in assembling and disassembling process
B. Quality consultation and testing
C. Monitoring
D. Assisting in planning and implementing of quality assurance
procedure

87. Which drug quantification method estimates the need for specific
drugs based on the expected incidence of common diseases?
A. Service level projection budget requirement
B. Morbidity method
C. Consumption method
D. Adjusted consumption method
88. Anemia is associated with:
A. Lamuvudine
B. Zidovudine
C. Neverapine
D. Stavudine
89. A 10 year old boy who was taking anti epileptic drug developed an
overgrowth of gum tissue (gingival hyperplasia). This patient was most
likely receiving which of the following agents:
 A. Carbamazepine
B. Ethosuximide
C. Clonazepam
D. Phenytoin
90. Advise to “keep medication for ten minutes on skin and rinse” is
given during dispensing of antifungal :
A. Ointments
B. Shampoos
C. Creams
D. Lotions
91. An adverse effect produced by drugs on fetuses is called;
A. Carcinogenic
B. Pathogenic
C. Toxic
D. Teratogenic
92. The mechanism of action of Norfloxacillin is
A. Cell wall synthesis inhibition
B. Foliate synthesis inhibition cv
C. DNA gyrase inhibition
D. Cell membrane synthesis inhibition
93. Simvastatin is a medication that is used to lower and manage high
level of
A. Uric acid
B. Sodium
C. Cholesterol
 D. Blood sugar

94. An 18 years old girl came to your health institution for advice after
a rape attack by a known HIV positive man. What do you advice and
recommended to this case?
A. To start ART treatment immediately after consulting a physician
B. To take co-trimoxazole for opportunistic infection
C. To take post exposure prophylaxis after consulting a physician
D. To wait for her CD4 count to reach below 200 to start ARV
treatment
95. Among the documents used for drug supply management ,the one
used as a consumption record is;
A. Goods receiving note
B. Store requisition form
C. Daily dispensing registry(DDR)
D. Store issue voucher
96. Among the communication process steps one is used by the speaker
to ensure the listener has properly understood the message:
A. Encoding
B. Feedback
C. Channel of communication
D. Decoding
97. Which type of quality control focuses on making sure the processes
are functioning correctly?
 A. Control charts
B. Process control
C. Acceptance sampling
D. Process protocol
98. 0
100. The “seven rights” of medication does not include:
A. Time
B. Route
C. Drug
D. Pharmacy

101. A psychotropic substance:

A. Chlorpromazine
B. Clonazepam
C. Morphine
D. Carbamazepine
102. Drugs used to treat erectile dysfunction should be used with
precaution because they have:
A. Physiological addiction
B. Sexual impotence risks
C. Cardiovascular risks
D. Infertility risks
103. For PCP adjunctive treatment prednisolone 40mg BID for 5 day,
then 30mg BID for 5 days, then 20mg BID for 5 days, then 10mg for 5
days, then 10mg QD for 5 days, if the available dose of predinsolone is
10mg.Calculate total predinsolone dispensed for 25 days?
A. 210
B. 110
C. 105
D. 100
104. A class example of loop diuretic drugs:
A. Fursomide
B. Nicodamid
C. Hydrochlorothiazide
D. Spironalactone
105. According to the Ethiopian regulations one of the following drugs
is not stocked in a drug store:
A. Clonazepam
B. Clotrimazole
C. Amoxicillin
D. Cloxacillin
106. ABC analysis of drugs can be made based on total annual cost of
each drug in our hospital drug list to identify and compute the few
items which are major budget consumers. This can simply be computed
by using micro soft office suit software:
A. MS Word
B. MS Access
C. MS Excel
D. MS Power point
 107. One of filowing class must not be dispersed without
prescription፦
A. Antihelmentics
B. Antibacterial
C. Antistamines
D. Antacids
108. The mechanism of action of Norfloxacillin is፦
A. Cell wall synthesis inhibition
B. DNA gyrase inhibition
C. Cell membrane synthesis inhibition
D. Foliate synthesis inhibitio
109. System of transporting and storing vaccines is referred as፦
A. Ice bag
B. Room temperature
C. Deep freez
D. Cold chain
110. Infilamatory conditions associated with asthma and other lung
disease are mainly controlled and treated by፦
A. Surfactants
B. Anti infective
C. Corticosteroids
D. Mucolytic agents
111. Motion stickiness can be treated with
A. Chlormphenicol
B. Pethidin
C. Gentamycin
D. Dimenhydrinate
112. If two drug with the effect take together and produce an effect
that is greater than in magnitude to the sum of the effects the drugs
given individually the interaction is known as፥
A. Synergism
B. Additive
C. Antagonsim
D. Agonist
113. Identitfy the one is catagorezed to histamine 2 blockers
A. Pantoprazol
B. Rantidin
C. Coprofloxacin
D. Omeprazole
114. The firest in team leaderships is
A. Cordinating and balancing
B. Sharing responsibility
C. Providing the information
D. Establishing a clear vision
115. Flammable and explosive materials should be stored in a
segregated place what all necessary safety precautions to avoid
explosion one of such chemicals is ;
A. Dietary acetic acid
B. Ammonium nitrate
C. Sodium cloride
D. Ascorbic acid
116. Potent steroidal anti inflammatory topical preparetion are not
adivesed to dispensed with a prescription because of the
A. High damends
B. Skin beautifying effect
C. Effect of increased risk of damege
D. Prices
117. Wich one of following diseases are aggravat covid -19 to death?
A. Pneumonia
B. Headach
C. Heart
D. Common cold
118. The vitamins that are used to treat covid -19 disease:
A. Vit C
B. Vit K
C. Vit B
D. Vit E
119. S-form of Omeprazole is less potent than R-form of Omeprazol.
So wich one of the following is R-form of Omeprazol ?
A. Esomeprazol
B. Rabeprazol
C. Pantoprazol
D. Omeprazol
120. Wich drug is cause cinchonism?
A. Quindine
B. Lidocaine
C. Digoxin
D. Amiodarone
121. From the given wich drug is cause anemia?
A. Didanosine
B. Zidovudine
C. Stavudine
D. Lamivudine
122. Wich one of following antibacterial drug is not available for oral
adiminstration?
A. Tetracycline
B. Gentamycin
C. Ciprofloxacin
D. Erthromycin
123. Non-verbal means of commonication.
A. Communication involves words throug talking
B. Communication throug words
C. Body gesture
D. Spoken communication
124. With one of the following drugs are grouped under NRTI?
 A. Neverapine
B. Zidovudine
C. Delavirdine
D. Ritonavire
125. Wich one of the folliwing is not controlled drugs?
A. Diazepam
B. Amitriptyline
C. Pentazosine
D. Ethidine
126. A new product has arrive to your pharmacy. The storege
requirements on the lebel read: Store at 1.5°C -3.3°C. Where woude
you store them!?
A. Room temperatur
B. Rifargratore
C. Incubator
D. Frozen
126. Eye contact, facial expression, gestures and touch are ;
A. Non-verbal communication
B. Verbal communication
C. Barrier to communication
D. Written communication
127. Folic acid supplement is highly advised to be teken by women in
child bearing age and pregnancy. Because shorteg of folic acid
A. Shortage of acidity in the amniotic
B. Shortage of follicle stmulating hormone
C. Congenital abinormality on the fetues
D. Vomiting and morning sickness
128. Identify the drug wich can be used to lower on acid level in
trments.....
A. Allopurinol
B. Amoxacillin
C. Paracetamol
D. Ibuprofen
129. Management of pharmaceutical service Should on principles and
processes of management and this may not include ;
A. Planning
B. Monitoring
C. Organizing
D. Shirning
130.Civide -19 disease can be best explained as -
A. A disease of the western countries and white people
B. A disease. Caused by adeno viruses
C. An epidemic mainly prevalent in china
D. A global pandemic
131. Sexually transmitted disease can be prevented by ;
A. Vasectomy
B. Condom
C. Cooper T interautenne device
D. Drug for erectile dysfunction
132. One of the following prescription information is used to adjusting
of the dose of the drugs?
A. Name of the patient
B. Age
C. Address of the pationt
C. Doctor s signature
133. Discrimination should be avoided, and diversity inclusion should
be practiced in organization to build teamwork. Discrimination is not
commonly manifested with
A. Race and ethinic background
B. Skin color
C. Personal talents
D. Disability
134.The time the body start to respond to medication after
adminstration is..
A. Drug haf-life
B. On set of action
C. Plateau
D. Peak plasma level
135. Breast feeding mothor's should be properly counseled on
selection of a contraceptive mothed bearest milk secretion can be
lowered by
A. Femel condoms
B. Combined oral contraceptive pills
C. Intra uterine devices
D. Progesterone only oral contraceptive pills
136. Among the list below one is not used by tradtional medicine
practitioners for health...
A. Animal part body parts
B. Synthesized medicinal products
C. Mineral soil
D. Toots of plants
137. The viruse causing covid -19 infection is very dangerous mainly
due to its high ;
A. Mortality rate
B. Morbidity rate
C. Transmission rate
D. Cure rate
138. One of the following is different from the other?
A. Loratadine
B. Famotidine
C. Ranitidine
D. Cimetidine
139.Drug of choice for the. Prophylaxis of mother to child
transmission of HIV.
A. Zidovudine (AZT)
B. Nevirapine (NVP)
C. Effavirenz (EFV)
D.Lamivudine (3TC)
140. Which drug is preferred for treatment of hypertension during
pregnancy?
A. Captopril
B. Enalapril
C. Methyldopa
D.Telmisartan
141. Adrug that cause birth defects on the fetus due to drug is called
------------?
A. Drug-drug interaction
B. Drug toxicity
C. Teratogen
D. Enzyme inducer