Thermo Scientific Quadrupole MS 5.

1 Instrument
Control Software for GC-IC-LC Release Notes

Contents

• Introduction
• Important Information
• Supported Devices
• Minimum Requirements
• Recommended Software and Software Stack
• New Feature
• Known Issues
• Resolved Issues
• General Installation Information
• New Installations
• Windows 10 Configuration
• Reinstalling the Software
• Trademarks

Introduction This document provides installation instructions and release notes for the Thermo Scientific™ Quadrupole MS 5.1
instrument control software (ICS) for GC-IC-LC. The document also lists fixed issues in this version of the driver
and known issues still existing with the driver.
For information about installation, configuration, and use of the Quadrupole MS ICS, refer to the following:
• Electronic manuals
• Help files

Important You must have administrative privileges and log in with them to load new software on the computer.
Information

May 2023, Revision A

© 2023 Thermo Fisher Scientific Inc.
All rights reserved.
 Supported The following devices are supported:
Devices • ISQ EC single quadrupole LC-MS
• ISQ EC single quadrupole IC-MS
• ISQ EM single quadrupole LC-MS
• ISQ 7610 single quadrupole GC-MS
• ISQ 7000 single quadrupole GC-MS
• ISQ LT single quadrupole GC-MS
• ISQ QD single quadrupole GC-MS
• ISQ “classic” single quadrupole GC-MS
• TSQ 9610 triple quadrupole GC-MS
• TSQ 9000 triple quadrupole GC-MS
• TSQ 8000 Evo triple quadrupole GC-MS
• TSQ Duo triple quadrupole GC-MS
• TSQ 8000 triple quadrupole GC-MS

Minimum The minimum data system hardware and software configuration required for this software are the same as those for the
Requirements Thermo Scientific™ Chromeleon™ software. Note that layered applications and other software packages may have
different requirements. The system requirements in the following table apply to Microsoft™ Windows™ 10 data systems.

System Requirements
Hardware • 3.4 GHz processor with 16 GB RAM
• DVD drive
• Video card and monitor capable of 1680  1050 resolution
• 1000 GB hard drive
• Quad-core processor
Software • Microsoft™ Windows™ 10 Operating System (64-bit) English only
• Thermo Scientific™ Dionex™ Chromeleon 7.2.10 MUa or later, Chromeleon 7.3.0,
Chromeleon 7.3.1, or Chromeleon 7.3.2 software

Recommended When using the software, we recommend installing one of the versions of Thermo Scientific software listed in the
Software and following table for best compatibility. However, you may use any version that meets the requirements listed in the
Software Minimum Requirements section.
Stack Thermo Scientific Software Stack Recommended Version
Thermo Scientific™ Dionex™ Thermo Scientific Chromeleon 7.3.2 software
Chromeleon

New Feature Quadrupole MS 5.1 drivers support Thermo Scientific™ SmartStatus™ 1.0 software. SmartStatus software provides
information about the proper functioning of certain Thermo Scientific autosamplers, gas chromatographs (GC),
and mass spectrometers.

Known Issues The known issues are as follows:

#136—When moving between networked instruments, Client-Server configurations can require a connection retry
to view device ePanels.
#249—Show Advanced Autotune Configuration unchecked does not hide Advanced Autotune for GC-MS systems

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#387—When you run the Station IQ application after installing the Quadrupole MS for GC-LC-IC driver, the
report displays errors. The errors can be located in this directory: C:\Program Files
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC

Note The errors and recommendations in the Station IQ report are a typical and expected result. Instrument
performance is not affected.

Table 1 contains the file locations and error messages that might appear in the Station IQ report when the
Quadrupole MS for GC-LC-IC driver is installed on systems running Chromeleon 7.2.10 MUa or later,
Chromeleon 7.3.0, or Chromeleon 7.3.1 software.

Table 1. File Locations and Error Messages in the Station IQ Report of Chromeleon 7.2.10 or later, 7.3.0, or 7.3.1 Software (Sheet 1 of 2)

File Location Error Message

N/A Chromeleon 7 PDF Converter: The
expected value of 'Port name' is
'DionexCm7Port' but actually is 'LPT1:'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ 'E9C7CA4690E65FF4' but actually is
LCSQ.Inst.dll '256CC0BA0F150BF'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ '951065C5B03FB670' but actually is
LCSQ.ManualTune.exe 'DE708430C8C13631'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ '697BDDCFA5D3CD46' but actually is
LCSQ.Reporting.dll '5960D705C5C92755'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ 'F532D8F3E4C82D4B' but actually is
MS.Core.dll 'C177AEE43183C3AF'.
C:\Program Files The file is not installed on the computer.
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\
Q0FreqByFreqData.csv
C:\Program Files The file is not installed on the computer.
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\
Q0FreqBySetData.csv
C:\Program Files The file is not installed on the computer.
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\
Q1FreqByFreqData.csv
C:\Program Files The file is not installed on the computer.
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\
Q1FreqBySetData.csv
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ '8F071D6F3B3205FF' but actually is
Thermo.DDKMassSpec.CommonData.dll 'FABCB13EE51D6D16'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ 'DE6D89B0807D1851' but actually is
Thermo.DDKMassSpecCommon.dll '4013F8ED76153BFF'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ 'CB6F47EF814FA93F' but actually is
ThermoFisher.ISQEC.ConfigPlugin.dll '2DB5E2409D134C2B'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ 'A8CEAB45F4E95B60' but actually is
ThermoFisher.ISQEC.Driver.dll '11A1EE92E2603287'.

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 Table 1. File Locations and Error Messages in the Station IQ Report of Chromeleon 7.2.10 or later, 7.3.0, or 7.3.1 Software (Sheet 2 of 2)

File Location Error Message

C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ '6BD270917A9FACD7' but actually is
ThermoFisher.ISQEC.ICDriver.dll '773E4A220BB1519A'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ '6BD270917A9FACD7' but actually is
ThermoFisher.ISQEC.LCDriver.dll '773E4A220BB1519A'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V1\Drivers\Thermo\ISQEC\ '46BA580FC7C4E870' but actually is
ThermoFisher.ISQEC.RealTimeScan.exe '7D71A6FC484EB112'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V2\Drivers\Thermo\ISQEC\ 'E9C7CA4690E65FF4' but actually is
LCSQ.Inst.dll '256CC0BA0F150BF5'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V2\Drivers\Thermo\ISQEC\ 'F532D8F3E4C82D4B' but actually is
MS.Core.dll 'C177AEE43183C3AF'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V2\Drivers\Thermo\ISQEC\ 8F071D6F3B3205FF' but actually is
Thermo.DDKMassSpec.CommonData.dll 'FABCB13EE51D6D16'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V2\Drivers\Thermo\ISQEC\ '7044C0C192DFDD6E' but actually is
Thermo.DDKMassSpec.CommonUI.dll 'E036C967F113ABB4'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V2\Drivers\Thermo\ISQEC\ '27C0BC77AA4B75C3' but actually is
Thermo.DDKMassSpec.DataAccess.dll '3DDAF7CE4EF4B214'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V2\Drivers\Thermo\ISQEC\ '793D3E037AC7AE56' but actually is
Thermo.DDKMassSpec.MethodEditorPlugin.dll '9DCC279966684932'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V2\Drivers\Thermo\ISQEC\ ‘F087B175774920E8' but actually is
ThermoFisher.ISQEC.MethodEditorPlugin.dll '66E05A26B608F8CB'.
C:\Program Files The expected value of 'Fingerprint' is
(x86)\Thermo\Chromeleon\bin\DDK\V2\Drivers\Thermo\ISQEC\ 'CD1265652105E0CE' but actually is
ThermoFisher.ISQEC.SmartXPlugIn.dll '980B6489F07D0427'.

#586—Probes are not supported.

Resolved Table 2 lists the issues resolved in Quadrupole MS 5.1 instrument control software. An issue ID has been assigned
Issues for tracking purposes.
Table 2. Resolved Issue in Quadrupole MS 5.1 ICS

Issue ID Description
410 CM Time Mode method editor retention time shows error incorrectly.
446 Submitting transfer line or ion source temperatures to ePanel sometimes does not set setpoint.

General To install the software on a new data system (PC), you must configure the Ethernet port to ensure proper
Installation communication and allow communication through the firewall. In addition, you must modify power settings on the
data system to ensure that the system does not go into hibernation or sleep mode and on the Ethernet card (NIC) so
Information that it does not go into power save mode, which will disconnect the PC from the system.

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 Modifications to the device driver or improper disconnections while the MS is still configured can require an
instrument power-cycle to reestablish communication. Please unconfigure the instrument before performing a driver
upgrade or PC restart.
Please run the Preparation.bat file prior to installation.
Refer to the Chromeleon software installation instructions for further information.

New  To install the drivers:

Installations 1. Ensure that your data system (PC) meets the system requirements above. Layered software applications may have
different requirements. Please refer to applicable documentation for details.
2. Verify that Chromeleon 7 and any required service packs, quick fixes, or dependencies (such as Foundation),
have been installed.
3. Open the Quadrupole MS for GC-IC-LC folder on the desktop. (If needed, download the driver package from
an online repository such as Flexera, and store it on the desktop.)

Note Back up all the software in the installer folder onto a USB drive or external hard drive in case you need
to reinstall it later.

4. Run the file named Preparation.bat.

5. Install the software by double-clicking Thermo.Chromeleon.QuadrupoleMS_GC_IC_LC.msi. Follow the
steps to install the software.
6. Read the License Agreement, and if you accept the terms, select the I accept the terms in the License Agreement
check box.

7. Click the Install button.

8. The software will begin the installation process.
9. When process is complete, click Finish.

 To configure your instrument

1. Choose Start > Programs > Thermo Chromeleon 7 > Services Manager. The Chromeleon Services Manager
window opens.
2. In the Chromeleon Services Manager window, click the Configure instruments link.
3. Click the Add Instrument or Add Module icon in the menu bar. Next, click Configure.

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 Windows 10
Configuration
Configure the
Ethernet Port Note The mass spectrometer must be connected to the data system (PC) using the communication cable that
and Change ships with the system. No other Ethernet cables are supported, and failure to use the supplied cable will result in
Firewall problems with operation.
Settings
1. Turn on the computer and allow it to complete its boot processes.
2. Open the Network and Sharing Center.

3. Configure the network card that will connect to the mass spectrometer:
Note At the time of this release, only the Broadcom Netxtreme Gigabit Ethernet (NIC) card is supported,
connected directly only with the cable provided. Do not connect the ISQ Series instrument to any other card than
the Broadcom Netxtreme Gigabit Ethernet (NIC) card and DO NOT connect through a hub, switch or router.
a. Right-click on the card and select Rename to rename this connection. Rename it the same as your MS
model: for example, TSQ 9610, ISQ 7610, or ISQ EC.

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 b. Right-click on the MS connection you named in the previous step and select Properties to set the IP address.
c. Disable all the protocols, except the Internet Protocol (TCP/IP) Version 4, by un-checking the boxes.

d. Click on the Internet Protocol (TCP/IP) line to highlight it, and then select Properties.
e. Set the IP address of the MS by choosing the Use the Following IP Address radio button.

Note The IP address can be anything between 192.168.1.1 and 192.168.1.254, except for 192.168.1.234,
which is the default address used on the MS system.

f. Click OK to confirm, and click OK to save the changes and close the window for the MS connection
properties.

Change 1. Access the Windows Firewall.

Firewall
Settings

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2. Select Allow a Program or Feature Through Windows Firewall.
3. Depending on the User Account Control settings, you may need to select Change Settings to edit the firewall
settings.

4. Scroll through the list to select Xcalibur. Under the domain selection, click the check box as show below.

5. Click OK to confirm the firewall changes

6. Close the control panel.

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Change the 1. Access the Advanced System Settings.
System
Memory
Settings

2. The Advanced Systems Settings window open. Select the Advanced tab, then select the Settings button in the
Performance section. This opens the Performance Options window.

3. In the Performance Options window, select the Advanced tab.

4. Under Virtual Memory, select Change. This brings up a popup window that allows you to change the virtual
memory settings.

5. De-select Automatically Manage Paging File Size for All Drives by un-checking the check box.

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 6. Confirm that System Managed Size is selected, then click OK to close, then click OK again to close the
Performance Options window.

Note You will need to restart the data system for this change to take effect.

Change the 1. Access the Power Options.

System Power
Settings

2. Select the Balanced Plan radio button, then click Change Plan Settings.
3. Change Turn Off the Display to Never and Put the Computer to Sleep to Never, then select Save Changes to
apply these power plan settings.

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 Note These power settings must be changed for any new users who are added to the system. Only an
administrator is allowed to change these settings.

Configure To configure Microsoft .NET 3.5

Microsoft .NET 1. Go to Control Panel > Turn Windows Features On or Off.
3.5

2. Check the .NET Framework 3.5 (Includes .NET 2.0 and .NET 3.0) box.

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 Reinstalling  To reinstall the software:
the Software 1. Close all data acquisition and instrument control software.
2. Ensure that your data system (PC) meets the system requirements above. Layered software applications may have
different requirements. Please refer to applicable documentation for details.
3. Open Instrument Configuration.
4. In the Available Devices pane, select your MS instrument.
5. Under Configured Devices, click the type MS instrument installed, then click Remove. Do the same for the
other configured devices, such as the GC. Select Done to close Instrument Configuration.
6. Access Programs and Features to uninstall the previous installation.
7. Under the list of currently installed programs, locate Thermo.Chromeleon.QuadrupoleMS_GC_IC_LC.msi
and click on it. Click Uninstall.
8. The driver will uninstall automatically.
9. Open the Task Manager, select the Processes tab, and click on Image Name to alphabetize the processes.
Verify that the following process is not in the list: Thermo.Chromeleon.QuadrupoleMS_GC_IC_LC.driver.
10. Open the Quadrupole MS for GC-IC-LC folder on the desktop.

Note Back up all the software in the installer folder onto a USB drive or external hard drive in case you need
to reinstall it later.

11. Run the file named Preparation.bat.

12. Install the software by double-clicking Thermo.Chromeleon.QuadrupoleMS_GC_IC_LC.msi. Follow the
steps to install the software.
13. Read the License Agreement, and if you accept the terms, select the I accept the terms in the License Agreement
check box.

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 14. Click the Install button.
15. The software will begin the installation process.
16. When process is complete, click Finish.

 To configure your instrument

1. Choose Start > Programs > Thermo Chromeleon 7 > Services Manager. The Chromeleon Services Manager
window opens.
2. In the Chromeleon Services Manager window, click the Configure instruments link.
3. Click the Add Instrument or Add Module icon in the menu bar. Next, click Configure.

Trademarks Windows, Office, and Microsoft are registered trademarks of Microsoft Corporation in the United States and other
countries.
All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries.

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