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    Drug Name

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    alwiugc.02

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    Drug Name

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    alwiugc.02
    8 views2 pages

    Original Title

    DRUG-NAME

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    8 views2 pages

    Drug Name

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    alwiugc.02

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    © All Rights Reserved
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    DRUG NAME : AMLODIPINE (PROVASC)

    Description

    This medicine is a white, round, tablet imprinted with "IG" and "239". Amlodipine is a calcium channel blocker. It works by
    affecting the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels and lowers
    blood pressure, and increases the supply of blood and oxygen to the heart while reducing its workload.

    Indications / Uses

    used with or without other medications to treat high blood pressure. Lowering high blood pressure helps prevent strokes,
    heart attacks, and kidney problems. Amlodipine belongs to a class of drugs known as calcium channel blockers. It works by
    relaxing blood vessels so blood can flow more easily.

    Amlodipine is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and
    decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur.

    MECHANISM OF ACTION

    Mechanism of Action on Blood Pressure

    Amlodipine is considered a peripheral arterial vasodilator that exerts its action directly on vascular smooth muscle to lead to
    a reduction in peripheral vascular resistance, causing a decrease in blood pressure. Amlodipine is a dihydropyridine calcium
    antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the influx of calcium ions into both vascular smooth
    muscle and cardiac muscle. Experimental studies imply that amlodipine binds to both dihydropyridine and
    nondihydropyridine binding sites, located on cell membranes. The contraction of cardiac muscle and vascular smooth
    muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels. Amlodipine
    blocks calcium ion influx across cell membranes with selectivity. A stronger effect of amlodipine is exerted on vascular
    smooth muscle cells than on cardiac muscle cells Label. Direct actions of amlodipine on vascular smooth muscle result in
    reduced blood pressure.

    Mechanism of Action in Angina

    The exact mechanism by which amlodipine relieves the symptoms of angina have not been fully elucidated to this date,
    however, the mechanism of action is likely twofold: Amlodipine has a dilating effect on peripheral arterioles, reducing the
    total peripheral resistance (afterload) against which the cardiac muscle functions. Since the heart rate remains stable during
    amlodipine administration, the reduced work of the heart reduces both myocardial energy use and oxygen requirements.
    Dilatation of the main coronary arteries and coronary arterioles, both in healthy and ischemic areas, is another possible
    mechanism of amlodipine reduction of blood pressure. The dilatation causes an increase in myocardial oxygen delivery in
    patients experiencing coronary artery spasm (Prinzmetal's or variant angina) and reduces coronary vasoconstriction caused
    by smoking.

    ADVERSE EFFECTS
    - Dizziness, lightheadedness, swelling ankles/feet, or flushing may occur. If any of these effects last or get worse, tell your
    doctor or pharmacist promptly.

    - To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

    - Although this medication is effective in preventing chest pain (angina), some people who already have severe heart disease
    may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical
    help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain,
    shortness of breath, unusual sweating).

    - A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a
    serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble
    breathing.

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