Introduction: Medical Genetics: Minh Thong Le, PHD Department of Biotechnology, Internaltional University
Introduction: Medical Genetics: Minh Thong Le, PHD Department of Biotechnology, Internaltional University
Introduction: Medical Genetics: Minh Thong Le, PHD Department of Biotechnology, Internaltional University
Source: AFP/Getty
BRCA1 and BRCA2 are tumour
suppressor genes.
Source: https://www.preventovariancancer.ca
Source: https://www.preventovariancancer.ca
Some messages
• The good from the "Angelina Jolie" effect for the medical
genetics to community
• Mutations in BRCA1/2 does not always lead to cancer
(multifactorial inheretance, vary in type of mutations,…)
• How can scientists discover association between genes and
diseases?
• The value of the finding? Patent?
• The Vietnam sistuation?
What isAllMedical Genetics?
components of the human body are influenced by genes
Source: http://genetics.emory.edu/
Source: https://openi.nlm.nih.gov/
Source: wikipedia
Types of Genetic Diseases
• Single gene disorders
• Multifactorial disorders
• Chromosomal disorders
• Mitochondrial disorders
• Acquired somatic genectic disorders (cancer,..)
• Interaction of genectic factors and environment factors
epigenetics
Source: wikipedia
Examples: Single-Gene Disorders
Clubfoot
Cleft lip and cleft palate
Source: wikipedia
Rare diseases – rare variants