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    Dermatology at A Glance: 1-Stratum Basale 2-Stratum Spinosum 3-Stratum Granulosum 4-Stratum Corneum

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    manarhosam214

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    Dermatology at A Glance: 1-Stratum Basale 2-Stratum Spinosum 3-Stratum Granulosum 4-Stratum Corneum

    Uploaded by

    manarhosam214
    27 views4 pages

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    4_5944829569159664886

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    27 views4 pages

    Dermatology at A Glance: 1-Stratum Basale 2-Stratum Spinosum 3-Stratum Granulosum 4-Stratum Corneum

    Uploaded by

    manarhosam214

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    Dermatology At A Glance

    1-stratum basale 2-stratum spinosum 3-stratum granulosum 4-stratum corneum

    -deepest -(8-10 )cell layers, irregular, -(3-5 )cell layers - the uppermost
    polyhedral cells
    -single layer of cuboidal to -diamond shaped cells - 20-30 cell layers
    columnar cells -prickle cell layer: cytoplasmic
    -keratohyalin granules, lamellar - flattened dead cells
    processes
    - separated from the granules (corneocytes): packed with
    dermis by bm -desmosomes, intercellular keratin, dead keratinocytes
    - keratohyalin granules contain
    cement of glycoproteins,
    (basement membrane) keratin precursors - no nuclei or intracytoplasmic
    lipoproteins
    organelles
    - attached to the bm by - lamella gygranules contain the
    desmosomes contain
    hemidesmosomes glycolipids - secrete defensins which are part
    desmoplakins,, desmogleins,
    of first immune defense
    - germinative: desmocollins
    Langerhans create creatin
    mitotically active stem -dendritic cells can be found
    cells
    -differentiating keratinocytes,
    - contains melanocytes mthesize keratins
    +Merkel cells -larger than basal cells

    75
    & stratum lucidum
    - 2-3 cell layers - a thin clear layer consisting of eleidin
    - present in thicker skin (palms, soles) - (product of keratohyalin)

    Interdigitation
    Cells of epidermis
    • keratinocytes
    Downword
    • melanocytes projection
    • langerhans’ cells
    • merkel’s cell
    Upward digitation

    keratinocytes

    Diamond shape
    Cuboidal or
    Polyhedra
    columnar

    Dead

    76
    keratinocytes langerhans cell melancocyte merkel cell
    CNS ,eye ,Skin^^Site of melanocyte
    - predominant cell -dendritic -derived from neural crest Cells , so - basal layer
    (up about 85% of cells) -suprabasal Stratum
    has low mitotic activity
    -desmosomes Tactile
    spinasoum
    -mostly basal receptor
    - originate in the basal layer - antigen presenting cell -no dendrites
    -melanosomes
    - produce keratin - no desmosomes -neurosecretory granules
    -dendritic Sensation
    - form epidermal water barrier First line of defense -transducer for fine touch
    -no desmosomes
    - form vitamin d -associated with nerve endings

    Every 1 of melanocyte give


    pigmentation to 36 keratinocytes
    36 cells
    Epidermal Melanin unit

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