IJOrtho-52-108
IJOrtho-52-108
IJOrtho-52-108
to more accurately capture the time frame necessary for the Table 1: Search terms used in the PubMed, Cochrane,
development of avascular necrosis (AVN) of the humeral and Scopus databases
head. The study confirmed factors for screw cutout and had Proximal humerus AND Screw
similar rates of complications.9 Humerus fracture Plate
Since the publication of these two reviews, there has been Shoulder Locking plate
an increase in the literature, regarding locking plate fixation LCP
for proximal humerus fractures. In addition, studies have PHILOS
attempted to curtail the complication rates mentioned
S3
earlier with augmentation strategies such as fibular strut
Fracture fixation
allograft, autograft, cancellous chips, suture fixation of the
rotator cuff, and defined technical steps, regarding plate and Fracture healing
screw placement. Recent years have shown an increase in Open reduction internal fixation
the indications for the use of locking plates, as well as Osteosynthesis
reverse total shoulder arthroplasty versus hemiarthroplasty LCP=Locking compression plate
in the setting of proximal humerus fractures.10,11 Given
the relative infancy of locking plate fixation at the time of studies were graded in accordance with the Journal of Bone
prior systematic reviews, and the small number of studies and Joint Surgery and Centre for Evidence-Based Medicine
included within each review, a more recent systematic guidelines, to universally assess the level of evidence of
review of the literature is warranted. This study examines each study. Statistics were performed by authors with
the current literature to evaluate complications experienced training in biostatistics. Complication rates were analyzed
with locking plate in light of changes to operative technique in a simple manner, first divided by the total number of
as familiarity with this implant has increased. fractures treated and followed by stratification by level of
evidence. There were no comparative analyses performed
Materials and Methods due to the heterogeneity of each study.
Following preregistration with PROSPERO
(CRD42015019038), a comprehensive search of the
Results
literature was performed in November 2013 and repeated The initial query conducted through the PubMed, Scopus,
in February 2015, to capture recent publications, utilizing and Cochrane databases identified 51,206 citations. After
the PubMed, Cochrane, and Scopus databases.12 Database removing duplicates and articles with irrelevant titles and
queries were performed using modifiers, limiting results to abstracts, a total of 191 full-text articles were assessed
publications in the English language of the past 10 years, for eligibility. From these 191 articles, 57 articles were
in studies involving human subjects. Search terms were included to be a part of this systematic review. The results
intentionally broad to identify all relevant articles [Table 1]. of screening and application of inclusion/exclusion criteria
are outlined in Figure 1.14-70
The study design was conducted strictly in accordance with
the PRISMA guidelines.12 The results were subsequently There were seven Level 1, three Level 2, 10 Level 3, and
filtered for duplicates, and titles and abstracts were 37 Level 4 studies. Level 1 and 2 studies included control
manually screened for relevance and potential adherence groups in regard to surgical approaches, nonoperative
to our inclusion criteria. To be included, eligible studies treatment, various treatment modalities, or deferring
must have been conducted in the past 5 years (modifier in operative techniques. Some Level 3 studies had a basis for
initial query was 10 years to ensure broadness of search), comparison when evaluating different surgical approaches
involving 10 or more subjects, adults aged 18 years or or operative techniques. Finally, Level 4 studies were
older, and a minimum average followup of 12 months. case series without a basis for comparison. Some of these
International studies with the English translation were series investigated techniques such as strut allografts,
included. Studies involving pathologic fractures, nonhuman suture fixation, bone grafting, and minimally invasive
subjects (in vitro studies), and cadavers were excluded. surgery.
Publications with overlapping or duplicate patient
There were a total of 3422 proximal humerus fractures that
populations were excluded.
were treated with locking plate. Certain studies failed to
Next, articles were assigned a quality score using a mention or report the presence or absence of complications that
previously published quality scoring system, which was were specifically being investigated. If this occurred, the study
also used by Sproul et al.9,13 The scoring system took into was not included in the complication’s analysis. The most
account the quality of the study design, as well as the quality common complication was intraarticular screw penetration
of its information. Two reviewers scored the articles and (9.5%), followed by varus collapse (6.8%), subacromial
only studies with a minimum score of 7/10 were included. impingement (5.0%), AVN (4.6%), adhesive capsulitis (4.0%),
Disagreements were resolved by consensus. Finally, the nonunion (1.5%), and deep infection (1.4%). Reoperation
11,450 records
11,259 titles/abstracts
Table 3: Rate of varus collapse
excluded Level Percentage of Percentage Rate (%)
occurrences of fractures
1 11 116 9.5
191 full-text articles
2 4 23 17.4
3 19 316 6.0
134 articles excluded
4 50 788 6.3
Total 84 1243 6.8
57 articles included
supplemental suture fixation of the rotator cuff in the five discover predictors of necrosis, following a proximal
cases of varus collapse and also used structural allograft in humerus fracture. Hertel et al. determined that the most
the setting of severe osteopenia.16 relevant factors included integrity of the medial hinge,
length of the dorsomedial metaphyseal extension, and
Subacromial impingement (5.0%)
different fracture types.72 Furthermore, growing indications
Subacromial impingement can be the result of poor for reverse total shoulder arthroplasty and recent favorable
intraoperative plate positioning or the sequelae of humeral studies in comparison to hemiarthroplasty may have
head collapse. Impingement is frequently symptomatic artificially decreased the rate of AVN currently being
and may require plate removal. Sproul et al. reported this reported.73 In addition, AVN may present later in followup
complication at a rate of 4.8%.9 Increased attention to plate and inadequate lengths of followup would, in turn, under
placement and preventing varus collapse are the methods report this complication. Recent studies have attempted to
surgeons are using to decrease this complication. use deltoid-splitting or minimally invasive approaches with
the belief that less soft tissue disruption in proximity to the
Level 1
humeral head would preserve its blood supply. Finally,
Only one study mentioned a case of subacromial there is growing belief that asymptomatic cases of AVN can
impingement. Olerud et al. reported one patient in their potentially over-report this serious complication.
treatment group of 27 cases with three-part fractures,
Level 1
who subsequently required plate removal. The authors
recommended averting humeral head collapse to prevent Comparing the minimally invasive approach to the
this complication.48 deltopectoral approach, Liu et al. reported one case of
AVN in the latter group and zero in the former. The authors
Level 2
believed that the minimally invasive approach decreased
Konrad et al. attributed their cases of impingement to soft tissue stripping and preserved the blood supply around
placing the plate too superiorly, leading to five cases in the proximal humerus.39 Zhang et al. reported only one
their study population of 270.34 case of AVN in their study that focused on medial support
Level 3 screws using a deltopectoral approach. In their opinion,
preventing medial collapse also aided in preventing AVN.69
Lin et al. attributed their cases of impingement to varus Interestingly, the findings from Fjalestad et al. showed that
collapse, while Jung et al. attributed their one case to nonoperatively treated patients had a higher rate of AVN
intraoperative error.31,37 Jung et al. described their operative than those in the operative group. All patients had displaced
positioning of the plate following reduction as caudal to three- and four-part fractures.27
the superior end of the greater tuberosity and lateral to the
bicipital groove.31 Bachelier et al. instead specified plate Level 2
position 1 cm caudal to the superior aspect of the greater Buecking et al. reported no case of AVN and no difference
tuberosity.15 between deltoid-splitting and deltopectoral approaches.
Followup, however, was only for 1 year.19 Schliemann et al.
Level 4
reported a lower incidence of AVN in patients treated with
Sahu reported no case of impingement, taking the shoulder their CFR-PEEK implant compared to conventional locking
through a range of motion arc before closure of the wound plate. Their followup was for a minimum of 2 years.58
to detect any symptoms of impingement.55 Osterhoff et al.
Level 3
described the majority of their 10 cases of impingement to
be strongly associated with medial calcar comminution.49 Martetschlager et al. reported higher rates of AVN in
Ricchetti et al. positioned the locking plate 5 mm–10 mm patients treated with a deltopectoral approach compared
lateral to the bicipital groove and 15 mm–20 mm caudal to to a minimally invasive deltoid-splitting approach. With a
the tip of the greater tuberosity. Two patients in their series mean followup of nearly 4 years, AVN was diagnosed in
of 54 cases had postoperative subacromial impingement six of 33 patients in the deltopectoral approach group and
symptoms.52 Finally, Aggarwal et al. described one of 37 patients in the deltoid-splitting approach group.41
provisionally fixing the plate with K-wires and placing the Wu et al. reported similar findings over a mean followup
shoulder through a range of motion arc under fluoroscopy. of 2.5 years in comparing a minimally invasive approach to
This technique resulted in five cases of impingement in a deltopectoral approach.67
their series of 47.14
Level 4
Avascular necrosis (4.4%)
Using a minimally invasive plating technique and a mean
AVN has been a historic concern with proximal humerus followup of nearly 3 years, Chen et al. reported only one
fractures. Sproul et al. reported this rate to affect 10.8% case of AVN in their series of 64 cases.21 Little et al.
of patients.9 This has even led to studies attempting to reported low rates of AVN as well by using a deltoid
with supplemental suture fixation of rotator cuff. J Shoulder polyaxial locking plate in the treatment of displaced proximal
Elbow Surg 2011;20:616-24. humerus fractures. A reliable system? Injury 2012;43:223-31.
17. Barco R, Barrientos I, Encinas C, Antuña SA. Minimally 34. Konrad G, Hirschmüller A, Audige L, Lambert S, Hertel R,
invasive poly-axial screw plating for three-part fractures of the Südkamp NP, et al. Comparison of two different locking
proximal humerus. Injury 2012;43 Suppl 2:S7-11. plates for two-, three- and four-part proximal humeral
18. Barlow JD, Sanchez-Sotelo J, Torchia M. Proximal fractures – Results of an international multicentre study. Int
humerus fractures in the elderly can be reliably fixed with Orthop 2012;36:1051-8.
a “hybrid” locked-plating technique. Clin Orthop Relat Res 35. Kralinger F, Blauth M, Goldhahn J, Käch K, Voigt C, Platz A,
2011;469:3281-91. et al. The influence of local bone density on the outcome of
19. Buecking B, Mohr J, Bockmann B, Zettl R, Ruchholtz S. one hundred and fifty proximal humeral fractures treated with a
Deltoid-split or deltopectoral approaches for the treatment of locking plate. J Bone Joint Surg Am 2014;96:1026-32.
displaced proximal humeral fractures? Clin Orthop Relat Res 36. Kumar C, Gupta AK, Nath R, Ahmad J. Open reduction and
2014;472:1576-85. locking plate fixation of displaced proximal humerus fractures.
20. Cai M, Tao K, Yang C, Li S. Internal fixation versus shoulder Indian J Orthop 2013;47:156-60.
hemiarthroplasty for displaced 4-part proximal humeral fractures 37. Lin T, Xiao B, Ma X, Fu D, Yang S. Minimally invasive plate
in elderly patients. Orthopedics 2012;35:e1340-6. osteosynthesis with a locking compression plate is superior
21. Chen Y, Zhang K, Qiang M, Li H, Dai H. Computer-assisted to open reduction and internal fixation in the management of
preoperative planning for proximal humeral fractures by the proximal humerus fractures. BMC Musculoskelet Disord
minimally invasive plate osteosynthesis. Chin Med J (Engl) 2014;15:206.
2014;127:3278-85. 38. Little MT, Berkes MB, Schottel PC, Lazaro LE, LaMont LE,
22. Chowdary U, Prasad H, Subramanyam PK. Outcome of Pardee NC, et al. The impact of preoperative coronal plane
locking compression plating for proximal humeral fractures: deformity on proximal humerus fixation with endosteal
A prospective study. J Orthop Surg (Hong Kong) 2014;22:4-8. augmentation. J Orthop Trauma 2014;28:338-47.
23. Clavert P, Adam P, Bevort A, Bonnomet F, Kempf JF. Pitfalls 39. Liu K, Liu PC, Liu R, Wu X. Advantage of minimally invasive
and complications with locking plate for proximal humerus lateral approach relative to conventional deltopectoral approach
fracture. J Shoulder Elbow Surg 2010;19:489-94. for treatment of proximal humerus fractures. Med Sci Monit
24. de Kruijf M, Vroemen JP, de Leur K, van der Voort EA, Vos DI, 2015;21:496-504.
Van der Laan L, et al. Proximal fractures of the humerus in 40. Liu ZZ, Zhang GM, Ge T. Use of a proximal humeral internal
patients older than 75 years of age: Should we consider operative locking system enhanced by injectable graft for minimally
treatment? J Orthop Traumatol 2014;15:111-5. invasive treatment of osteoporotic proximal humeral fractures in
25. Duralde XA, Leddy LR. The results of ORIF of displaced elderly patients. Orthop Surg 2011;3:253-8.
unstable proximal humeral fractures using a locking plate. 41. Martetschläger F, Siebenlist S, Weier M, Sandmann G,
J Shoulder Elbow Surg 2010;19:480-8. Ahrens P, Braun K, et al. Plating of proximal humeral fractures.
26. Egol KA, Sugi MT, Ong CC, Montero N, Davidovitch R, Orthopedics 2012;35:e1606-12.
Zuckerman JD, et al. Fracture site augmentation with calcium 42. Matassi F, Angeloni R, Carulli C, Civinini R, Di Bella L,
phosphate cement reduces screw penetration after open Redl B, et al. Locking plate and fibular allograft augmentation in
reduction-internal fixation of proximal humeral fractures. unstable fractures of proximal humerus. Injury 2012;43:1939-42.
J Shoulder Elbow Surg 2012;21:741-8. 43. Matejcić A, Vidović D, Ivica M, Durdević D, Tomljenović M,
27. Fjalestad T, Hole MØ, Hovden IA, Blücher J, Strømsøe K. Bekavac-Beslin M, et al. Internal fixation with locking plate
Surgical treatment with an angular stable plate for complex of 3- and 4-part proximal humeral fractures in elderly patients:
displaced proximal humeral fractures in elderly patients: Complications and functional outcome. Acta Clin Croat
A randomized controlled trial. J Orthop Trauma 2012;26:98-106. 2013;52:17-22.
28. Gaheer RS, Hawkins A. Fixation of 3- and 4-part proximal 44. Miyazaki AN, Estelles JR, Fregoneze M, Santos PD, da Silva LA,
humerus fractures using the PHILOS plate: Mid-term results. do Val Sella G, et al. Evaluation of the complications of surgical
Orthopedics 2010;33:671. treatment of fractures of the proximal extremity of the humerus
29. Gavaskar AS, Chowdary N, Abraham S. Complex proximal using a locking plate. Rev Bras Ortop 2012;47:568-74.
humerus fractures treated with locked plating utilizing an 45. Norouzi M, Naderi MN, Komasi MH, Sharifzadeh SR,
extended deltoid split approach with a shoulder strap incision. Shahrezaei M, Eajazi A, et al. Clinical results of using the
J Orthop Trauma 2013;27:73-6. proximal humeral internal locking system plate for internal
30. Hirschmann MT, Fallegger B, Amsler F, Regazzoni P, Gross T. fixation of displaced proximal humeral fractures. Am J
Clinical longer-term results after internal fixation of proximal Orthop (Belle Mead NJ) 2012;41:E64-8.
humerus fractures with a locking compression plate (PHILOS). 46. Ockert B, Siebenbürger G, Kettler M, Braunstein V,
J Orthop Trauma 2011;25:286-93. Mutschler W. Long term functional outcomes (median 10 years)
31. Jung WB, Moon ES, Kim SK, Kovacevic D, Kim MS. Does after locked plating for displaced fractures of the proximal
medial support decrease major complications of unstable humerus. J Shoulder Elbow Surg 2014;23:1223-31.
proximal humerus fractures treated with locking plate? BMC 47. Olerud P, Ahrengart L, Soderqvist A, Saving J, Tidermark J.
Musculoskelet Disord 2013;14:102. Quality of life and functional outcome after a 2-part proximal
32. Kim SH, Lee YH, Chung SW, Shin SH, Jang WY, Gong HS, humeral fracture: A prospective cohort study on 50 patients treated
et al. Outcomes for four-part proximal humerus fractures treated with a locking plate. J Shoulder Elbow Surg 2010;19:814-22.
with a locking compression plate and an autologous iliac bone 48. Olerud P, Ahrengart L, Ponzer S, Saving J, Tidermark J. Internal
impaction graft. Injury 2012;43:1724-31. fixation versus nonoperative treatment of displaced 3-part
33. Königshausen M, Kübler L, Godry H, Citak M, Schildhauer TA, proximal humeral fractures in elderly patients: A randomized
Seybold D, et al. Clinical outcome and complications using a controlled trial. J Shoulder Elbow Surg 2011;20:747-55.
49. Osterhoff G, Hoch A, Wanner GA, Simmen HP, Werner CM. randomized clinical observational study. J Orthop Trauma
Calcar comminution as prognostic factor of clinical outcome 2011;25:596-602.
after locking plate fixation of proximal humeral fractures. Injury 66. Wild JR, DeMers A, French R, Shipps MR, Bergin PF,
2012;43:1651-6. Musapatika D, et al. Functional outcomes for surgically
50. Pak P, Eng K, Page RS. Fixed-angle locking proximal humerus treated 3- and 4-part proximal humerus fractures. Orthopedics
plate: An evaluation of functional results and implant-related 2011;34:e629-33.
outcomes. ANZ J Surg 2013;83:878-82. 67. Wu CH, Ma CH, Yeh JJ, Yen CY, Yu SW, Tu YK, et al. Locked
51. Parmaksizoğlu AS, Sökücü S, Ozkaya U, Kabukçuoğlu Y, plating for proximal humeral fractures: Differences between
Gül M. Locking plate fixation of three- and four-part proximal the deltopectoral and deltoid-splitting approaches. J Trauma
humeral fractures. Acta Orthop Traumatol Turc 2010;44:97-104. 2011;71:1364-70.
52. Ricchetti ET, Warrender WJ, Abboud JA. Use of locking plates 68. Yang H, Li Z, Zhou F, Wang D, Zhong B. A prospective clinical
in the treatment of proximal humerus fractures. J Shoulder study of proximal humerus fractures treated with a locking
Elbow Surg 2010;19:66-75. proximal humerus plate. J Orthop Trauma 2011;25:11-7.
53. Robinson CM, Wylie JR, Ray AG, Dempster NJ, Olabi B, 69. Zhang L, Zheng J, Wang W, Lin G, Huang Y, Zheng J, et al. The
Seah KT, et al. Proximal humeral fractures with a severe varus clinical benefit of medial support screws in locking plating of
deformity treated by fixation with a locking plate. J Bone Joint proximal humerus fractures: A prospective randomized study. Int
Surg Br 2010;92:672-8. Orthop 2011;35:1655-61.
54. Röderer G, Erhardt J, Graf M, Kinzl L, Gebhard F. Clinical 70. Zhu Y, Lu Y, Shen J, Zhang J, Jiang C. Locking intramedullary
results for minimally invasive locked plating of proximal nails and locking plates in the treatment of two-part proximal
humerus fractures. J Orthop Trauma 2010;24:400-6. humeral surgical neck fractures: A prospective randomized trial
55. Sahu RJ. Minimally invasive percutaneous plate osteosynthesis with a minimum of three years of followup. J Bone Joint Surg
for the treatment of proximal humerus fractures in osteoporotic Am 2011;93:159-68.
patients with Philos plate. Bangladesh J Med Sci 2013;12:140-5. 71. Ricchetti ET, DeMola PM, Roman D, Abboud JA. The use of
56. Sanders RJ, Thissen LG, Teepen JC, van Kampen A, Jaarsma RL. precontoured humeral locking plates in the management of
displaced proximal humerus fracture. J Am Acad Orthop Surg
Locking plate versus nonsurgical treatment for proximal humeral
2009;17:582-90.
fractures: Better midterm outcome with nonsurgical treatment.
J Shoulder Elbow Surg 2011;20:1118-24. 72. Hertel R, Hempfing A, Stiehler M, Leunig M. Predictors
of humeral head ischemia after intracapsular fracture of the
57. Schliemann B, Siemoneit J, Theisen C, Kosters C, Weimann A,
proximal humerus. J Shoulder Elbow Surg 2004;13:427-33.
Raschke MJ. Complex fractures of the proximal humerus in the
elderly-outcome and complications after locking plate fixation. 73. Wang J, Zhu Y, Zhang F, Chen W, Tian Y, Zhang Y, et al.
Musculoskelet Surg 2012;96:s3-11. Meta-analysis suggests that reverse shoulder arthroplasty
in proximal humerus fractures is a better option than
58. Schliemann B, Hartensuer R, Koch T, Theisen C, Raschke MJ,
hemiarthroplasty in the elderly. Int Orthop 2016;40:531-9.
Kösters C, et al. Treatment of proximal humerus fractures
with a CFR-PEEK plate: 2-year results of a prospective study 74. Kirchhoff C, Braunstein V, Kirchhoff S, Sprecher CM, Ockert B,
and comparison to fixation with a conventional locking plate. Fischer F, et al. Outcome analysis following removal of locking
plate fixation of the proximal humerus. BMC Musculoskelet
J Shoulder Elbow Surg 2015;24:1282-8.
Disord 2008;9:138.
59. Schulte LM, Matteini LE, Neviaser RJ. Proximal periarticular
75. Brorson S, Rasmussen JV, Frich LH, Olsen BS,
locking plates in proximal humeral fractures: Functional
Hróbjartsson A. Benefits and harms of locking plate
outcomes. J Shoulder Elbow Surg 2011;20:1234-40.
osteosynthesis in intraarticular (OTA type C) fractures
60. Sharma V, Balvinder S, Khare S. Management of proximal of the proximal humerus: A systematic review. Injury
humeral fractures with proximal humerus locking plate – A 2012;43:999-1005.
prospective study. J Orthop Trauma Rehabil 2014;18:89-93.
76. Tepass A, Rolauffs B, Weise K, Bahrs SD, Dietz K, Bahrs C,
61. Sohn HS, Shin SJ. Minimally invasive plate osteosynthesis et al. Complication rates and outcomes stratified by treatment
for proximal humeral fractures: Clinical and radiologic modalities in proximal humeral fractures: A systematic literature
outcomes according to fracture type. J Shoulder Elbow Surg review from 1970-2009. Patient Saf Surg 2013;7:34.
2014;23:1334-40.
77. Jost B, Spross C, Grehn H, Gerber C. Locking plate fixation of
62. Spross C, Platz A, Rufibach K, Lattmann T, Forberger J, fractures of the proximal humerus: Analysis of complications,
Dietrich M, et al. The PHILOS plate for proximal humeral revision strategies and outcome. J Shoulder Elbow Surg
fractures – Risk factors for complications at one year. J Trauma 2013;22:542-9.
Acute Care Surg 2012;72:783-92. 78. Handoll H, Brealey S, Rangan A, Keding A, Corbacho B,
63. Trepat AD, Popescu D, Fernandez-Valencia JA, Cune J, Rios M, Jefferson L, et al. The proFHER (PROximal fracture of the
Prat S. Comparative study between locking plates versus humerus: Evaluation by randomisation) trial – A pragmatic
proximal humeral nail for the treatment of 2-part proximal multicentre randomised controlled trial evaluating the clinical
humeral fractures. Eur J Orthop Surg Traumatol 2012;22:373-9. effectiveness and cost-effectiveness of surgical compared with
64. Verdano MA, Lunini E, Pellegrini A, Corsini T, Marenghi P, non-surgical treatment for proximal fracture of the humerus in
Ceccarelli F, et al. Can the osteosynthesis with locking plates adults. Health Technol Assess 2015;19:1-280.
be a better treatment for unstable fractures of the proximal 79. Bae JH, Oh JK, Chon CS, Oh CW, Hwang JH, Yoon YC, et al.
humerus? Musculoskelet Surg 2014;98:27-33. The biomechanical performance of locking plate fixation with
65. Voigt C, Geisler A, Hepp P, Schulz AP, Lill H. Are polyaxially intramedullary fibular strut graft augmentation in the treatment
locked screws advantageous in the plate osteosynthesis of of unstable fractures of the proximal humerus. J Bone Joint Surg
proximal humeral fractures in the elderly? A prospective Br 2011;93:937-41.