BÃ I 7 Major Metabolic Pathways in Biochemistry (Version 1)
BÃ I 7 Major Metabolic Pathways in Biochemistry (Version 1)
BÃ I 7 Major Metabolic Pathways in Biochemistry (Version 1)
Glycolysis pathway
Glycolysis pathway
Glycolysis pathway
Citric Acid Cycle
Citric Acid Cycle
Citric Acid Cycle
The citric acid cycle (CAC) – also known as the tricarboxylic acid (TCA) cycle or the Krebs
cycle[1][2] – is a series of chemical reactions used by all aerobic organisms to release stored
energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins
into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP).
In addition, the cycle provides precursors of certain amino acids, as well as the reducing
agent NADH, that are used in numerous other biochemical reactions.
The NADH generated by the citric acid cycle is fed into the oxidative phosphorylation
(electron transport) pathway. The net result of these two closely linked pathways is the
oxidation of nutrients to produce usable chemical energy in the form of ATP.
In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In
prokaryotic cells, such as bacteria which lack mitochondria, the citric acid cycle reaction
sequence is performed in the cytosol.
Urea Cycle
Urea Cycle
The urea cycle (also known as the ornithine cycle) is a cycle of biochemical
reactions that produces urea ((NH2)2CO) from ammonia (NH3). The urea cycle
converts highly toxic ammonia to urea for excretion.[1] This cycle was the first
metabolic cycle to be discovered (Hans Krebs and Kurt Henseleit, 1932), five
years before the discovery of the TCA cycle. The urea cycle takes place primarily
in the liver and, to a lesser extent, in the kidneys.