Psych Article
Psych Article
Psych Article
Manuscript version of
Funded by:
• National Institute on Aging
© 2020, American Psychological Association. This manuscript is not the copy of record and may not exactly
replicate the final, authoritative version of the article. Please do not copy or cite without authors’ permission.
The final version of record is available via its DOI: https://dx.doi.org/10.1037/adb0000551
This article is intended solely for the personal use of the individual user and is not to be disseminated broadly.
1
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
Abstract
substance use, and emotional distress across generations, and the association with child
aggression. The study included 218 generation one (G1) mothers and fathers and their adolescent
(generation two; G2) who participated from middle adolescence through adulthood, and the
third-generation (G3) child between ages 3-5 years and 6-10 years old. G1 behavior was
examined when G2 was 16 and 18 years old; G2 alcohol problems and marijuana use were
assessed when G2 was 19 and 21 years old. G2 emotional distress and harsh parenting were
examined when the G3 child was between 3 and 5 years old. Finally, G3 aggression was assessed
between 6 and 10 years old. Results showed continuity of G1 behavior when G2 was in
both associated with G3 aggression through G2 alcohol problems, G2 emotional distress and G2
the family of origin plays an important role in G2 alcohol problems in emerging adulthood which
Key words: Intergenerational transmission, substance use, harsh parenting, emotional distress,
aggressive behavior
2
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
There is evidence that problem behavior such as harsh parenting, substance use, and
emotional distress are transmitted across generations (Bailey, Hill, Oesterle, & Hawkins, 2006;
Bailey, Hill, Oesterle, and Hawkins, 2009; Kavanaugh, Neppl, & Melby, 2018; Jeon & Neppl,
2019; Neppl, Conger, Scaramella, & Ontai, 2009). Indeed, generation one (G1) substance use
and hostile parenting as experienced during generation two (G2) adolescence, increases G2
substance use and other deviant behaviors into emerging adulthood (Diggs & Neppl, 2018; Yap,
Cheong, Zaravinos-Tsakos, Lubman, & Jorn, 2017). As adults, G2 is likely to continue such
behavior, as well as become harsh parents themselves, which relates to negative outcomes for the
third generation (G3) child (Jeon & Neppl, 2019; Neppl et al., 2009). Bailey et al. (2006) found
evidence for G1 to G2 continuity of substance use, which led to problem behavior for the G3
Despite this evidence, more research is needed regarding mechanisms that might help
explain associations between G1 and G2 problem behavior, and problem behavior for the G3
child. For example, Bailey et al. (2006) suggest that potential pathways such as harsh parenting
should be investigated in the association between G1 substance use and G3 problem behavior.
According to the Family Stress Model (FSM; Conger & Conger, 2002), stressors as experienced
in the family of origin are associated with emotional distress and disrupted family relationships
in adulthood, and poor developmental outcomes for the next generation child. Specifically, early
stressors such as family economic adversity relate to parental emotional distress that leads to
harsh parenting practices, which in turn are associated with next generation externalizing
3
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
behavior in early childhood (Neppl, Senia, & Donnellan, 2016), and alcohol use from
adolescence to emerging adulthood (Diggs & Neppl, 2018). Therefore, it seems reasonable that
adulthood. This problem behavior then leads to G2 harsh parenting. Hence, G2 outcomes turn
into predictors of G2 behavior that ultimately impact the G3 child. Understanding these
associations are critical as G3 problem behavior in childhood relates to early alcohol and other
substance use (Kerr, Capaldi, Pears & Owen, 2012). Thus, G3 behavior is both a consequence of
G1 and G2 behavior and a marker of their own potential use (Kerr, et al., 2012). These pathways
can be supplemented by the Social Learning Theory (Bandura, 1977), which allows for modeling
and direct associations between parent and child behavior. That is, the intergenerational
continuity of behavior may occur when individuals exposed to problem behaviors during
childhood emulate this same type of problem behavior when they become adults. These
environmental risk factors may also interact with genetic vulnerability to help explain problem
behavior, as well as poor parenting practices (see Moffit, 2005). Moreover, due to heritability
and parental rearing influences, there could be an underlying liability of transmissible risk where
problem behaviors are a manifestation of behavioral under control (i.e., Tarter et al., 2015).
With these ideas in mind, the present investigation extends earlier research on the
parenting during G2 adolescence, on G2 alcohol problems and marijuana use from late
adolescence into emerging adulthood. We also evaluated the influence of G2 alcohol and
marijuana use in emerging adulthood on G2 emotional distress and harsh parenting when G3 was
4
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
externalizing behavior during the early elementary years. Finally, we examined the indirect
It is well established that substance use is one type of problem behavior transmitted from
the parent to the next generation child (Yap, et al., 2017). For example, parent alcohol use is
related to adolescent alcohol use (Brook et al., 2010), alcohol use in emerging adulthood
(Knight, Menard, & Simmons, 2014), as well as to other substances such as marijuana
(McCutcheon et al., 2017). Nadel and Thornberry (2017) found that mother adult substance use
defined by alcohol and marijuana use, was a risk factor for offspring substance use and other
problem behaviors. Relatedly, Capaldi, Tiberio, Kerr, and Pears (2016) found that mother
alcohol use was associated with their child’s onset and use of alcohol. Thus, while mother use
has received less attention in research than father use, mother substance use may play a
significant role in child use (Capaldi, Tiberio, & Kerr, 2018). Moreover, adolescents may be
more likely to develop problem drinking if exposed to parents who drank moderately or heavily
than those with parents who never or occasionally drank alcohol (Alati et al., 2014). Indeed,
adolescents with parents diagnosed with DSM-III-R substance abuse were more likely
themselves to be dependent on alcohol and other drugs (Hoffmann & Cerbone, 2002). Finally, in
addition to substance use disorders, adolescents exposed to parental problem drinking are at
higher risk of life stress and psychological problems (Brook et al., 2010).
Research also demonstrates that those who engage in heavy drinking during adolescence
likely continue this problematic drinking into emerging adulthood (Thompson, Stockwell,
Leadbeater, & Homel, 2014). Indeed, Diggs and Neppl (2018) examined the continuity of
5
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
alcohol use from middle adolescence to emerging adulthood. They found alcohol use at age 16
predicted binge drinking in late adolescence, which led to binge drinking in emerging adulthood.
In addition, Henry and Augustyn (2017) found that individuals who began using cannabis by age
15 were more likely to meet criteria for a lifetime cannabis disorder. Finally, Windle and
Wiesner (2004) classified adolescents into trajectory groups based on patterns of change in
cannabis use and found that adolescent trajectory group membership significantly predicted
cannabis and alcohol disorders in young adulthood. Though the stability of adolescent substance
use is well documented, few studies, if any, have examined the influence of G1 problem
behavior on the continuity of G2 substance use to predict G2 emotional distress and G2 harsh
There is also evidence that parenting in the family of origin is associated with parenting
behavior in the subsequent generation (e.g., Conger, Neppl, Kim, & Scaramella, 2003; Pears &
Capaldi, 2001; Simons, Whitbeck, Conger, & Wu, 1991). For example, Conger et al. (2003)
found a direct association between G1 hostile parenting experienced during G2 adolescence and
G2 hostile parenting to their G3 child in adulthood. Bailey et al. (2009) found continuity in
parental monitoring and harsh discipline practices across generations. Moreover, research also
suggests that G1 parenting is associated with G2 alcohol use. Indeed, harsh parenting practices
predict adolescent drinking (Kim-Spoon, Farley, Holmes, & Longo, 2014) that extends into
emerging adulthood (Aquilano & Supple, 2001). As such, G2 problem behavior may be an
early study, Caspi and Elder (1988) demonstrated that G1 hostile parenting predicted G2
problem behavior in childhood which was associated with G2 hostile parenting to G3. Similarly,
6
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
Neppl et al. (2009) found that G2 externalizing behavior in adulthood mediated the association
adulthood. More recently, Augustyn, Thornberry, and Henry (2019) demonstrated that child
maltreatment victimization increased alcohol use and other problem behavior in adolescence,
which increased their engagement in maltreatment behaviors in adulthood. Finally, Bailey et al.
(2009) found associations between G1 harsh discipline and G1 substance use with G2
behavior in early adolescence was related to G2 substance use when G2 was in adulthood, which
was then associated with G3 externalizing at the same time period (Baily et al., 2009).
The continuity of emotional distress (which may include anxiety, depressive symptoms,
and hostility) across generations is also well-documented (Stein et al., 2014). For example, Kim,
Capaldi, Pears, Kerr and Owen (2009) examined the intergenerational transmission of broad
internalizing behavior including depression across three generations. They found that G1 mother
internalizing behavior assessed when G2 was 9 to 12 years old was associated with G2
associated with the internalizing behavior of the G3 child. Others demonstrate that maternal
depressive symptoms increase risk for depression in both adolescence (Monti & Rudolph, 2017)
and adulthood (Betts, Williams, Naiman, & Alati, 2015). Indeed, Jones et al. (2016) found that
family history of distress influenced mental functioning throughout adulthood. In addition, after
controlling for externalizing symptoms, Rothenberg, Hussong, and Chassin (2018) found that
Moreover, adolescent substance use is associated with later emotional distress, which can
influence their own child’s behavioral outcomes. Indeed, emotional distress such as depression
7
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
often co-occurs with substance use in adulthood (Biederman et al., 2005), predicts substance use
(King & Chassin, 2008), or is a consequence of using substances (Trim, Meehan, King, &
Chassin, 2007). It also relates to child problem behavior (Kavanaugh, et al., 2018; Kim-Cohen,
Moffitt, Taylor, Pawlby, & Caspi, 2005; Neppl et al., 2016). For example, Thornberry, Freeman-
Gallant, and Lovegrove (2009) found that mother depressive symptoms when their child was 7
years old mediated the association between mother adolescent drug use and their child’s early
onset of antisocial behavior. Mother depressive symptoms indirectly related to child antisocial
behavior through its impact on parenting. Relatedly, Diggs and Neppl (2018) found that early
stress (i.e., economic adversity) was associated with parental emotional distress, which led to
harsh parenting behavior toward their child. Thus, parental emotional distress may not only be
transmitted across generations, but also provide a link between parent substance use and child
problem behavior. That is, it is plausible that adolescent substance use can lead to later emotional
distress, which influences harsh parenting behavior in adulthood. Taken together, the current
The current study examined the transmission of problem behavior across generations.
substance use, G2 emotional distress and harsh parenting in adulthood, and G3 aggressive
behavior within the same model. We used data from a two-decade longitudinal study of G2s and
alcohol problems, and harsh parenting during G2’s adolescence (Time 1). G2 alcohol problems
8
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
and marijuana use were assessed in late adolescence (Time 2) and emerging adulthood (Time 3).
G2 emotional distress and harsh parenting to G3 were assessed during G3’s preschool years
(Time 3), and G3 aggressive behavior was examined in the early elementary years (Time 5). We
expected continuity of emotional distress, substance use, and harsh parenting from G1 to G2. We
further expected that G1 behavior would relate to G2 substance use in late adolescence and
substance use in emerging adulthood would then relate to G2 emotional distress. It was expected
that G2 emotional distress would relate to G2 harsh parenting in adulthood, which would then
We also controlled for original family structure, G1 per capita income, G1 mother and
father age, G2 early adolescent alcohol use, G2 gender, G2 marital status, G2 age at time 4, and
G3 gender and G3 age at times 4 and 5. Previous research shows that these variables may be
related to substance use and parenting behaviors. For example, economic hardship relates to both
emotional distress and family conflict (Neppl et al., 2016). Younger mothers may be more likely
to show signs of harsh parenting toward their children than mothers who are older in age
(Scaramella, Neppl, Ontai, & Conger, 2008). Moreover, in young childhood, males tend to have
higher levels of externalizing behavior than their female counterparts (Pogarsky, Thornberry, &
Lizotte, 2006).
Method
Participants
Data come from the Family Transitions Project (FTP), a longitudinal study of 559 youth
and their families. The FTP includes participants merged from two earlier studies known as the
Iowa Youth and Families Project (IYFP) and the Iowa Single Parent Project (ISPP). Data were
9
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
first collected from IYFP (N = 451) in 1989 and continued annually through 1992. Participants
included the target adolescent, their parents, and a sibling within 4 years of age (52% male).
IYFP families were initially recruited to study the effects of family economic stress in the rural
Midwest, following an economic farm crisis that occurred in the late 1980s. The target
adolescents were in seventh grade when families were first interviewed (M age = 12.7 years). All
families were recruited across schools in eight rural counties in Iowa (99% Caucasian). Seventy-
eight percent of families agreed to participate, and most families were lower middle- or middle-
class with about 34% residing on farms, 12% living in nonfarm rural areas, and 54% living in
towns with fewer than 6,500 people. In 1989, parents averaged 13 years of education and had a
median family income of $33,700. Fathers averaged 40 years of age and mothers averaged about
38 years of age.
Beginning in 1991, the ISSP included target adolescents who were in ninth grade and the
same age as the IYFP targets who had been participating for the previous two years (M age =
14.8 years) Single-parent mothers and a sibling within 4 years of age of the ISSP target
adolescent also participated (N = 108). Families in the ISSP were headed by a single mother who
had experienced divorce within two years prior to the start of the project. Only three families did
not participate. Like the IYFP, participants in the ISPP were Caucasian, primarily lower middle-
or middle-class, one-parent families who lived in the same Midwestern area. Non-residential
fathers were also recruited to participate in a short telephone survey. Measures and procedures
In 1994, the IYFP and ISSP samples were combined to create the FTP when target
adolescents from both studies were in twelfth grade. In the first year of the FTP, target youth
participated in the study with their parents as they had during earlier years of adolescence.
10
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
Starting in 1995, the target adolescents (one year after completing high school for most)
participated in the study with their romantic partners. In 1997, the study expanded to include the
first-born child of the target adolescents, now adults. The target’s child had to be at least 18
months old to be eligible for the study. By 2005, children ranged from 18 months to 13 years old.
The present study included 218 G2 adults who participated from adolescence through
adulthood and had an eligible G3 child participating in the study by 2005. It also included G2’s
mother and father (when applicable). Informed consent was obtained by G1 and G2, each for
their own participation and the participation of the G3 child. The data were analyzed using five
developmental time periods. Time 1 examined G1 emotional distress, G1 alcohol problems, and
G1 harsh parenting to G2 during G2’s adolescence (age 16, 18; 1992, 1994). Time 2 included G2
alcohol problems and G2 marijuana use (age 19; 1995). Time 3 included G2 alcohol problems
and G2 marijuana use two years later (age 21; 1997). Time 4 included G2 emotional distress and
G2 harsh parenting towards G3 when the child was between the ages of 3 and 5 years old (1997-
2005). Time 5 included G3’s aggressive behavior between the ages of 6 and 10 (1999-2005).
The current study includes data from the first time G3 participated in each developmental
period between the ages of 3 to 5 (1997-2005) and the ages of 6 to 10 (1999-2005). This was to
assure the same child was not counted within that age range multiple times at both time 4 and 5.
At time 4, there was a total of 181 3-year-olds, 24 4-year-olds, and 5 5-year-olds. At time 5,
there was a total of 132 6-year olds, 37 7-year olds, 38 8-year olds, 2 9-year olds, and 1 10-year
old (99 females, 111 males). The FTP has been approved by the Institutional Review Board at
Procedures
11
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
During the years of 1992, and 1994, when G2s were in the 10th and 12th grades, all
families of origin were visited twice each year by a trained interviewer in their homes. Each visit
lasted approximately 2 hours, with the second visit occurring within 2 weeks of the first. During
the first visit, each family member completed questionnaires pertaining to their relationships,
substance use, and individual characteristics. During the second visit, family members
participated in structured interaction tasks that were videotaped. The family interaction task was
used for the present study, in which family members discussed questions from a series of 20
cards labeled for either the mother or the adolescent. Each person took turns reading questions
related to subjects such as school activities, family rules, and household chores. Whoever read
the card first was instructed to read each question out loud and give their answer. Then, the
others were instructed to give their answers, followed by a discussion involving all family
members about the answers that were given. Once they felt they had said everything they wanted
to about the question, they were instructed to go onto the next card. The interviewer set up the
video camera, instructed the family through a practice card, and then left the room while the
participants completed the task. Independent trained observers coded the quality of interactions
using the Iowa Family Interaction Rating Scales (Melby et al., 1998), which have been shown to
From 1997 through 2005, G2 parents, their romantic partner, and first-born G3 child were
visited in their home annually by a trained interviewer. During this visit, the G2 and his/her
substance use, and individual characteristics. In addition to questionnaires, G2 adults and their
G3 child participated in videotaped interaction tasks. The parent-child puzzle completion task
was used in the current analyses. G2s and the G3 child were presented with a puzzle that was too
12
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
difficult for the child to complete on their own, and parents were instructed that children must
complete the puzzle alone, but they could provide any assistance if necessary. The puzzle task
lasted 5 minutes. The puzzles varied by age so that the puzzle slightly exceeded the skill level of
the child. Trained observers watched the video-recorded puzzle tasks to code aspects of
parenting using the Iowa Family Interaction Rating Scales (Melby et al., 1998).
Measures
The means, standard deviations, sample sizes, and minimum and maximum scores for all
G1 Emotional Distress (Time 1). Emotional distress was assessed through G1 self-
report using items from the depression, anxiety, and hostility subscales from the SCL-R-90
(Derogatis, 1994) when the G2 adolescent was 16 and 18 years old. Response categories
assessed how distressed mothers and fathers felt during the past week, ranging from 1 (not at all)
to 5 (extremely). For the depression scale, parents were asked 12 questions regarding depressive
symptoms such as feeling no interest in things or feelings of worthlessness (α = .94). The anxiety
suddenly feeling scared for no reason, and feeling fearful (α = .91). Finally, hostility included 5
items asking questions related to getting into frequent arguments, having temper outbursts that
you were unable control, and having the urge to break or smash things (α = .77). Items from each
subscale were averaged across the two waves for mothers and fathers and then parental
depressive symptoms, anxiety, and hostility were used as three separate indicators for the latent
G1 Alcohol Problems (Time 1). G1 alcohol problems were assessed via self-report
when G2 adolescents were 16 and 18 years of age. Three items assessing drinking behavior were
13
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
standardized and summed for mothers and fathers separately. Then, mother and father scores
were averaged to create a parental alcohol problems construct in the model. The independent
items used were frequency of being drunk in the past year on a scale from 0 (never) to 3 (often),
frequency of consuming 2 or 3 drinks in a single occasion in the past year, and consuming 4 or
more drinks in a single occasion in the past year, with the latter two both on scales from 0
(never) to 3 (3 or more times/week). Internal consistency among these variables was sufficient (α
= .82).
G1 Harsh Parenting (Time 1). Hostility, angry coerciveness, and antisocial behavior
displayed by G1 to the G2 adolescent during the videotaped family discussion task were assessed
when G2 adolescents were 16 and 18 years of age. Each behavior was scored on a 9-point scale,
ranging from 1 (no evidence of the behavior) to 9 (the behavior is highly characteristic of the
mother). Hostility was characterized by hostile, annoyed, critical, and disapproving behavior
toward the adolescent. Angry coercion was defined by an attempt to control or change the
rebellious, and indifferent behavior toward the adolescent. Mother and father scores on each of
the three behaviors were averaged together across the two waves, and then parental hostility,
angry coercion, and antisocial behavior were used as separate indicators for the latent construct
G2 Alcohol Problems (Time 2). Five independent self-reported items at age 19 were
averaged together to create the G2 alcohol problems construct. First, G2s reported on their
frequency of consuming 3 or 4 drinks in a row in the past 30 days and consuming 5 or more
drinks in a row in the past 30 days on a scale from 0 (never) to 5 (every day). They also reported
their frequency in the past year of being drunk, in trouble with their parent(s), as well as being in
14
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
trouble with the police due to their drinking on a scale from 0 (never) to 3 (four or more times).
These five items were standardized and summed to create a measure of G2 alcohol problems at
time 2 in the model. Internal consistency among the items was sufficient (α = .87).
G2 Marijuana Use (Time 2). Also at age 19, G2 adolescents assessed how often they
had used marijuana in the past 30 days on a scale from 0 (never) to 5 (every day) via self-report.
G2 Alcohol Problems (Time 3). Six independent self-reported items at age 21 were
averaged together for the G2 alcohol problems construct at time 3. The same five items used in
the time 2 alcohol problems construct were used, as well as the frequency of wanting to quit
drinking but couldn’t on a scale from 0 (never) to 3 (four or more times). These six items were
standardized and summed to create a measure of G2 alcohol problems at time 3 in the model.
G2 Marijuana Use (Time 3). Also at age 21, G2 emerging adults assessed how often
they used marijuana in the past 30 days on a scale from 0 (never) to 5 (every day) via self-report.
distress using the same items as G1 emotional distress from the depression, anxiety, and hostility
subscales from the SCL-R-90 (Derogatis, 1994) at the age of first assessment when the G3 child
was between the ages of 3 and 5 years old. Items from each subscale were averaged and then
used as three separate indicators for the latent construct in the model (α = .86).
G2 Harsh Parenting (Time 4). As with G1 to G2, hostility, angry coerciveness, and
antisocial behavior from the G2 mother to the G3 child were assessed via observer report during
the 5-minute puzzle task in childhood. Scores included the first time the task was completed
when the child was between the ages of 3 and 5. Each of the three behaviors were used as
separate indicators for the latent construct in the model and were internally consistent (α = .93)
15
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
as well as demonstrated excellent inter-rater reliability (α = .95). The observers used to code the
G1 to G2 parenting tasks were different from observers who coded the G2 to G3 puzzle task.
Thus, different informants produced the behavioral scores for harsh parenting at Times 1 and 4.
G3 Aggression. G2 parents completed the Child Behavior Checklist for ages 6-18
(Achenbach & Rescorla, 2000) when their child was between 6 and 10 years old. Scores
included the first time the child was assessed during that age range. Aggressive behavior
included 18 items from the aggression subscale. G2 parents rated each behavior on a 3-point
scale, ranging from 0 (not true) to 2 (very true) regarding their child’s behavior over the past two
months. Items included: argues a lot, gets into fights, attacks people, makes threats, hot temper,
and is disobedient at home and school. The Cronbach’s alpha coefficient indicated adequate
internal consistency (α = .84). Items were summed to create the manifest dependent variable in
the model.
Control Variables. First, original family structure (ISPP = 0, IYFP = 1) was taken into
account. The G1 control variables measured when the G2 adolescent was 16 years old included
mother and father age and family per capita income (divided by $10,000). G2 earlier alcohol use
at age 16 was assessed via self-report asking the frequency of drinking beer, wine, and liquor in
the past 30 days rated on a scale from 0 (never) to 3 (at least 1 time/week). Both G2 and G3
gender was also used as control variables in the model (0 = female, 1 = male). G2 age at time 4
and G3 age at times 4 and 5 were taken into account. Finally, G2 marital status at time 4 (0 = not
Analytic Plan
16
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
SPSS was used to report means, standard deviations, and Cronbach’s alphas on all study
variables. Attrition analyses were also conducted in SPSS using independent samples t-tests to
assess whether or not G2s who were included in the analysis had different levels of substance use
at times 2 and 3 than those who were not included. Results indicated that mean levels of alcohol
problems or marijuana use at times 2 or 3 did not differ significantly between those who were
included in the analyses versus those who were not (m = -.09 vs. .06 for time 2 alcohol problems;
m = .21 vs. .12 for time 2 marijuana use; m = -.34 vs. .23 for time 3 alcohol problems; and m =
.24 vs. .19 for time 3 marijuana use). Factor loadings and the zero-order associations between
variables (see Table 2), using bivariate correlations at a significance level of 0.05, were
examined in Mplus Version 8.0 (Muthen & Muthen, 2012) with a measurement model. Structure
equation modeling (SEM) was estimated using Mplus Version 8.0 to examine pathways of how
predictor variables were associated with the outcome variables on the hypothesized paths (see
Figure 1), using full information maximum likelihood (FIML) procedures to account for missing
account for missing data (Allison, 2003). FIML provides a better estimation of model parameters
than methods such as listwise or pairwise deletion (Jeličić, Phelps, & Lerner, 2009). The chi-
square estimate and significance value were used to assess model fit, as well as root mean square
error approximation (RMSEA), and comparative fit index (CFI; Browne & Cudeck, 1993).
A measurement model was first examined to assess the associations among all study
variables, as well as obtain factor loadings for the latent constructs. Next, a prospective structure
equation model was tested to assess relations among hypothesized pathways as well as to
establish temporal ordering. Pathways included in the prospective structure equation model are
shown in Figure 1. All control variables were utilized in the final model. More specifically, G1
17
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
family per capita income, G1 mother age, G1 father age, G2 alcohol use at age 16, and original
family structure were allowed to covary with G1 emotional distress, G1 alcohol problems, and
G1 harsh parenting. These control variables were used as predictors of the G2 and G3 constructs
in the model. G2 age and marital status were allowed to be correlated with G2 emotional distress
and G2 harsh parenting as well as specified to predict G3 aggression. G3 age at time 4 was
allowed to be correlated with G2 emotional distress and G2 harsh parenting, as well as predict
gender was used to predict G3 aggression. All control variables were specified to be associated
Mplus Version 8.0, per recommendation of Preacher and Hayes (2008) due to how easily
multivariate normality can be violated when estimating multiple indirect effects. We tested the
indirect effects using the bootstrap option in Mplus with 1,000 iterations to obtain bias-corrected
estimates and 95% confidence intervals (CI) of the indirect effects. All indirect pathways were
tested from G1 substance use and problem behavior to G3 aggressive behavior through G2
substance use, emotional distress, and harsh parenting. The indirect effect from G2 emotional
Results
The fit of the measurement model, including all control variables, to the data was good:
2
χ = 271.03, df = 184, p < .001, CFI = .97, RMSEA =.05. Standardized loadings of indicators
onto the latent factors ranged from .85 to .97 for G1 harsh parenting, .81 to .99 for G2 harsh
parenting, .57 to 1.0 for G1 emotional distress, and .77 to .85 for G2 emotional distress and were
all statistically significant at p < .001. Most notably, G1 emotional distress was associated with
18
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
G2 emotional distress. G1 alcohol problems were associated with G2 alcohol problems at times 2
and 3. G1 harsh parenting was associated with G2 harsh parenting. Finally, G2 emotional
distress and harsh parenting when the G3 child was between the ages of 3 and 5 were both
positively correlated with G3 aggressive behavior between the ages of 6 and 10.
The prospective model was estimated with all specified control variables. The model fit
the data well, and result are presented in Figure 2 with standardized path coefficients. Emotional
distress was stable across generations (G1-G2; β = .24, SE = .09, p < .01) and was correlated
with G1 harsh parenting (r = .18, SE = .04, p < .05). G1 emotional distress predicted higher
levels of marijuana use at age 19 (β = .15, SE = .20, p < .05), but did not predict G2 alcohol
problems at the same time point (β = .01, SE = 1.12, p = .85). G1 alcohol problems was
associated with G2 alcohol problems at time 2 (β = .16, SE = .11, p < .05), but was not related to
G2 marijuana use at time 2 (β = .04, SE = .02, p = .58). Although the zero-order correlation
between G1 and G2 harsh parenting was significant in the measurement model, when taking all
other associations into account, this association was only marginally significant in the
prospective model (β = .13, SE = .06, p = .08). G1 harsh parenting predicted higher levels of
both G2 alcohol problems (β = .21, SE = .18, p < .01) and G2 marijuana use (β = .22, SE = .03, p
G2 alcohol problems at age 19 predicted further alcohol problems (β = .54, SE = .05, p <
.001) as well as marijuana use at age 21 (β = .27, SE = .01, p < .001). Marijuana use continued
from ages 19 to 21 (β = .42, SE = .08, p < .001), but did not predict continued alcohol problems
2 years later (β = -.10, SE = .32, p = .09). G2 alcohol problems and marijuana use were
correlated at both time points (r = .21, SE = .20, p < .01; r = .33, SE = .16, p < .001 respectively).
Although G2 marijuana use at time 3 was associated with G2 emotional distress in the
19
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
measurement model, when G2 alcohol use was added to the model, only alcohol problems at
time 3 predicted G2 emotional distress at time 4 (β = .34, SE = .01, p < .001). G2 emotional
distress was associated with G2 harsh parenting at the same time point, when the G3 child was
between the ages of 3 and 5 years old (β = .29, SE = .35, p < .001), which in turn was directly
associated with G3 aggression between the ages of 6 and 10 (β = .27, SE = .27, p < .01).
Indirect Effects
We tested the indirect effects of the associations between G1 problem behavior and G2
substance use, G1 harsh parenting and G2 harsh parenting, as well as effects of problem behavior
on G3 aggression (see Table 3). All indirect effects in the model were tested, but only significant
findings are shown in Table 3. For effects on G2 substance use, G1 emotional distress was
related to G2 marijuana use at age 21 through G2s’ use of marijuana at age 19. G1 alcohol
problems and G1 harsh parenting were both indirectly associated with G2 alcohol problems and
marijuana use at time 3 through G2 alcohol problems at time 2. Additionally, G1 harsh parenting
was associated with G2 marijuana use at time 3 through G2’s use of marijuana at time 2. In the
model, G1 harsh parenting was not directly associated with G2 harsh parenting when taking into
account all other variables, but was associated with G2 harsh parenting via G2 alcohol problems
and G2 emotional distress. In terms effects on G3 aggression, there was a significant indirect
effect from G2 emotional distress to G3 aggression through G2 harsh parenting when G3 was
between the ages of 3 and 5. G1 alcohol problems and G1 harsh parenting were both associated
with G3 aggression though G2 alcohol problems, G2 emotional distress, and G2 harsh parenting.
Discussion
The present investigation examined the role of G1 emotional distress, alcohol problems,
and harsh parenting on G2 substance use, emotional distress and harsh parenting during
20
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
adulthood, as well as G3 aggression in early childhood. This study adds to the literature
examining mechanisms that might help explain associations between G1 to G2 problem behavior
and problem behavior for the G3 child. First, results showed evidence of direct intergenerational
consistent with earlier studies demonstrating continuity of such behavior across generations
(Bailey et al., 2006; Kavanaugh et al., 2018; Neppl et al., 2009). Moreover, although the zero-
order correlation between G1 and G2 harsh parenting was significant, in the prospective model
this path was only marginally significant, but showed that G1 harsh parenting was associated
with G2 harsh parenting via G2 substance use and G2 emotional distress. Others have found that
G1 and G2 harsh parenting is associated through G2 problem behavior (Belsky, Conger, &
Capaldi, 2009; Neppl et al., 2009). Results also demonstrated that G1 harsh parenting in G2’s
adolescence directly related to both G2 alcohol problems and G2 marijuana use at age 19, and
the model showed continuity of G2 alcohol problems and marijuana use through the early
emerging adulthood years. This is consistent with previous research demonstrating associations
between G1 harsh parenting and G2 problem behavior (Hops, Davis, Leve, & Sheeber, 2003), as
well as studies that have found continuity of substance use from adolescence to adulthood (Diggs
substance use on G2 emotional distress and harsh parenting when G3 was 3 to 5 years old, and
G3 aggression during the early elementary years. Results showed significant indirect pathways
from both G1 alcohol problems and G1 harsh parenting to G3 aggression through G2 alcohol at
consistent with the premise that stressors experienced in the family of origin influence emotional
health and parenting in adulthood, which affects the wellbeing of the next generation child
(Neppl, et al., 2016). Relatedly, Bailey et al. (2006) examined the role of G1 substance use on
G3 problem behavior and found that G1 substance use indirectly related to G3 problem behavior
Results also showed that G1 emotional distress was associated with G2 marijuana use at
age 19, but not with alcohol problems at the same time point. There is some evidence to suggest
that marijuana use is related to coping with negative emotions and psychological distress
(Hyman & Sinha, 2009; Moitra, Christopher, Anderson, & Stein, 2015). However, to our
knowledge, limited studies have examined the intergenerational influence of emotional distress,
substance use, and parenting in one model. Future studies should continue to investigate the role
behaviors such as alcohol use and harsh parenting into account. In addition, results showed that
G2 alcohol problems at age 19 related to G2 marijuana use at 21 years old but not the other way
around. This is consistent with the developmental sequence of drug involvement, where the use
Moreover, the path from G2 marijuana use at age 21 to G2 emotional distress was also
not significant. It is important to note that when alcohol problems were not included in the
model, the path from G2 marijuana use to G2 emotional distress was significant, but when G2
alcohol problems were included in the model, this path was no longer significant. Indeed, there is
evidence of comorbidity between alcohol problems and depression (Grant and Harford, 1995),
and that drinking behaviors increase the risk for depressive symptoms (Pedrelli, Shapero,
Archibald, & Dale, 2016; Peirce, Frone, Russell, Cooper, & Mudar, 2000). It could also be that
22
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
rural young adults may be at a higher risk for substance use problems than those from urban
areas (Martin, Inchley, Marshall, Shortt, & Currie, 2019; Rueter, Holm, Burzette, Kim, &
Conger, 2007). In fact, a large majority of the rural G2 youth in the current study experienced a
high prevalence of substance use disorders with many continuing into adulthood (Rueter, et al.,
2007). Finally, results from the current study may also be in part due to the assessment of
marijuana use, rather than problems with the substance, as it has been suggested that stronger
associations may occur for abuse and dependence, rather than use (Bailey et al., 2006; Walters,
2002). Regardless, future studies should consider polysubstance use as alcohol and other drugs
There are limitations worth noting. First, the sample was primarily white and came from
the rural Midwest which could limit generalizability of findings. Also, multiple generation
studies might include selective sampling over time. Thus, while the current findings are
noteworthy, this model should be replicated with samples that are more diverse. Another
limitation is the current study did not include G1 marijuana in the model as no G1 mothers or
fathers engaged in marijuana use over the previous year. It is possible that in other samples, G1
marijuana use could relate to G3 aggressive behavior in the same manner as findings with
alcohol problems in the current study. Moreover, frequency of marijuana use was the only item
asked of G2s involvement specifically with marijuana. Thus, more items regarding amount or
problems with only marijuana are needed. In addition, alcohol problems included two
independent questions regarding frequency of drinking 3 or 4 more drinks in a row and 5 or more
drinks in a row. Participants provided a response to both items, however it is not probable they
would answer the same frequency for both items. This measure was worded such that consuming
3 or 4 drinks occurred on a separate occasion than drinking 5 or more drinks. Alcohol data were
23
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
also collected some time ago and may not be consistent with current trends. However, results
from the Iowa Youth Survey (IYS) indicate that adolescents in Iowa report alcohol problems
such as binge drinking rates higher than national averages (Iowa Consortium for Substance
G2 substance use and other problem behavior, there could be alternative explanations for the
current findings. For example, there could be shared genetic risk for substance use and
dependence for parents and adolescents (Polderman et al., 2015). Nevertheless, it is important to
investigate environmental factors that could contribute to substance use and later problem
These findings have several implications for future prevention and intervention efforts
designed to break the intergenerational continuity of problem behaviors, such as substance use
and emotional distress. Foremost, these results help elucidate the mechanisms through which
such problem behaviors experienced in the family of origin have lasting effects across multiple
child, and subsequent continuity of alcohol problems into G2 young adulthood was a critical link
in this process. Thus, the results underscore how intergenerational risk may be reduced if
substance use can be curtailed in adolescence, before problematic use patterns are established.
This view is supported by other research that has found evidence for intergenerational
transmission of substance use when considering continuity from substance use during emerging
adulthood, but not when limiting use to adolescence (Knight, Menard, and Simmons, 2014).
Although there are a number of universal prevention programs (school-based and family-
based) that have been found to reduce the likelihood of substance use during adolescence
(Fleming et al, 2012; Park et al., 2000; Spoth et al., 2009), recent trends in prevention science
24
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
highlight the importance of adaptive intervention strategies that tailor the type of intervention in
order to match the intervention strategy to the individual’s risk (Collins, Murphy, & Bierman,
2004). For example, the Family Check-Up (FCU; Dishion et al., 2002) is a multimodal family
intervention that is designed to reduce adolescent problem behavior and improve mental health
by supporting family engagement and improving parenting practices. The FCU uses a
specifically address a family’s strengths and needs and has been shown to reduce problem
behavior and substance use among adolescents (Caruthers, Van Ryzin, & Dishion, 2014;
Although there is evidence that interventions can also reduce risk behavior among
emerging adults, including binge drinking (Brody et al., 2012; Turrisi et al., 2013; Wood et al.,
2010), very few family-based interventions have been designed to target this vulnerable age.
Given the strong links found between G2 alcohol problems, emotional distress, and harsh
parenting, our results also highlight the importance of identifying and addressing barriers to
mental health services among all ages, but particularly during emerging adulthood when
prevalence rates of depression and other mental health disorders are highest (Cadigan, Lee, &
Larimer, 2019). Finally, our results also support the value of delivering interventions during the
G2 behavior, but is also shown to be a marker of the child’s own eventual use. (Averdijk, Zirk-
Sadowski, Ribeaud, & Eisner, 2016). In sum, results suggest that G1 problem behavior as
adulthood, which leads to G2 emotional distress and G2 harsh parenting in adulthood, which
References
Achenbach, T. M., Rescorla, L. A. (2000). Manual for the ASEBA Preschool Forms & Profiles.
University of Vermont, Research Center for Children, Youth, & Families; Burlington,
VT.
Alati, R., Baker, P., Betts, K., Connor, J., Little, K., Sanson, A., & Olsson, C. (2014). The role of
parental alcohol use, parental discipline and antisocial behaviour on adolescent drinking
doi:10.1016/j.drugalcdep.2013.09.030
Allison, P. D. (2003). Missing data techniques for structural equation modeling. Journal of
Aquilano, W. S., & Supple, A. J. (2001). Long-term effects of parenting practices during
Augustyn, M. B., Thornberry, T. P., & Henry, K. L. (2019). The reproduction of child
Averdijk, M., Zirk-Sadowski, J., Ribeaud, D., & Eisner, M. (2016). Long-term effects of two
Bailey, J. A., Hill, K. G., Oesterle, S., & Hawkins, J. D. (2006). Linking substance use and
problem behavior across three generations. Journal of Abnormal Child Psychology, 34,
273-292. https://doi.org/10.1007/s10802-006-9033-z
Bailey, J. A., Hill, K. G., Oesterle, S., & Hawkins, J. D. (2009). Parenting practices and problem
behavior across three generations: monitoring, harsh discipline, and drug use in the
Biederman, J., Petty, C., Faraone, S. V., Hirshfeld-Becker, D. R., Henin, A., Pollack, M. H., &
https://doi.org/10.1002/da.20055
Belsky, J., Conger, R. D., & Capaldi, D. M. (2009). The intergenerational transmission of
1204. doi:10.1037/a0016245
Betts, K. S., Williams, G. M., Naiman, J. M., & Alati, R. (2015). The relationship between
maternal depressive, anxious, and stress symptoms during pregnancy and adult offspring
http://dx.doi.org/10.1002/da.22272
Brody, G. H., Yu, T., Chen, Y. F., Kogan, S. M., & Smith, K. (2012). The adults in the making
program: Long-term protective stabilizing effects on alcohol use and substance use
problems for rural African American emerging adults. Journal of Consulting and Clinical
Brook, J. S., Balka, E. B., Crossman, A. M., Dermatis, H., Galanter, M., & Brook, D. W. (2010).
The relationship between parental alcohol use, early and late adolescent alcohol use, and
Browne, M. W. & Cudeck, R. (1993). Alternative ways of assessing model fit. In: Bollen KA,
Long JS, editors. Testing structural equation models. Newbury Park, CA.
Cadigan, J. M., Lee, C. M., & Larimer, M. E. (2019). Prevention Science, 20, 366-376.
https://doi.org/10.1007/s11121-018-0875-8
Capaldi, D. M., Tiberio, S. S., & Kerr, D. C. R. (2018). Assessing associations in substance use
across three generations: from grandparents to sons and from sons to their children.
Capaldi, D. M., Tiberio, S. S., Kerr, C. R., & Pears, K. C. (2016). The relationships of parental
alcohol versus tobacco and marijuana use with early adolescent onset of alcohol use.
Caruthers, A. S., Van Ryzin, M. J., & Dishion, T. J. (2014). Preventing high-risk sexual behavior
013-0383-9
Caspi, A., & Elder, G. H. (1988). Emergent family patterns: The intergenerational construction
Clarendon Press.
Collins, L. M., Murphy, S. A., & Bierman, K. (2004). A conceptual framework for adaptive
28
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
doi:10.1023/B:PREV.0000037641.26017.00
Conger, R. D. & Conger, K. J. (2002). Resilience in Midwestern families: Selected findings from
the first decade of a prospective, longitudinal study. Journal of Marriage and Family, 64,
Conger, R. D., Neppl, T., Kim, K., & Scaramella, L. (2003). Angry and aggressive behavior
Diggs, O. & Neppl, T. K. (2018). The influence of economic hardship on emerging adu lt
binge drinking: Testing the family stress model over time. Journal of Youth and
Dishion, T. J., Kavanagh, K., Schneiger, A., Nelson, S. E., & Kaufman, N. (2002). Preventing
early adolescent substance use: A family-centered strategy for the public middle school.
Fleming, C. B, White, H. R., Haggerty, K. P., Abbott, R. D., & Catalano, R. F. (2012).
Educational paths and substance use from adolescence into early adulthood. Journal of
Henry, K. L. & Augustyn, M. B. (2017). Intergenerational continuity in cannabis use: The role of
parent’s early onset and lifetime disorder on child’s early onset. Journal of Adolescent
Hoffmann, J. P. & Cerbone, F.G. (2002). Parental substance use disorder and the risk of
adolescent drug abuse: An event history analysis. Drug and Alcohol Dependence, 66,
255–264. https://doi.org/10.1016/S0376-8716(02)00005-4
Hops, H., Davis, B., Leve, C., & Sheeber, L. (2003). Cross-Generational Transmission of
Hyman, S. M., & Sinha, R. (2009). Stress-related factors in cannabis use and misuse:
implications for prevention and treatment. Journal of Substance Abuse Treatment, 36,
400-413. https://doi.org/10.1016/j.jsat.2008.08.005
Jeličić, H., Phelps, E., & Lerner, R. M. (2009). Use of missing data methods in longitudinal
https://doi.org/10.1007/s10802-019-00563-0
Jones, T. M., Hill, K. G., Epstein, M., Olivia Lee, J., Hawkins, J. D., & Catalano, R. F. (2016).
Kandel, D. B. (2003). Does marijuana use cause the use of other drugs? JAMA, 289(4), 482-483.
doi:10.1001/jama.289.4.482
30
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
Kavanaugh, S. A., Neppl, T. K., & Melby, J. N. (2018). Economic pressure and depressive
symptoms: Testing the family stress model from adolescence to adulthood. Journal
Kerr, D. C. R., Capaldi, D. M., Pears, K. C., & Owen, L. D. (2012). Intergenerational influences
on early alcohol use: Independence from the problem behavior pathway. Development
Kim, H. K., Capaldi, D. M., Pears, K. C., Kerr, D. C., & Owen, L. D. (2009). Intergenerational
https://doi.org/10.1002/cbm.708
Kim-Cohen, J., Moffitt, T. E., Taylor, A., Pawlby, S. J., & Caspi, A. (2005). Maternal depression
and children’s antisocial behavior: Nature and nurture effects. Archives of General
Kim-Spoon, J., Farley, J. P., Holmes, C. J., & Longo, G. S. (2014). Does adolescents'
religiousness moderate links between harsh parenting and adolescent substance use?
King, K. M., & Chassin, L. (2008). Adolescent stressors, psychopathology, and young adult
Knight, K. E., Menard, S., & Simmons, S. B. (2014). Intergenerational continuity of substance
Martin, G., Inchley, J., Marshall, A., Shortt, N., & Currie, C. (2019). The neighbourhood social
environment and alcohol use among urban and rural Scottish adolescents. International
McCutcheon, V. V., Agrawal, A., Kuo, S. I. C., Su, J., Dick, D. M., Meyers, J. L., ... & Schuckit,
M. A. (2018). Associations of parental alcohol use disorders and parental separation with
offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high‐risk
Melby, J., Conger, R., Book, R., Rueter, M., Lucy, L., Repinski, D., & Scaramella, L. (1998).
The Iowa Family Interaction Rating Scales. Fifth Edition Iowa State University, Institute
Melby, J. N., & Conger, R. D. (2001). The Iowa family interaction rating scales: Instrument
554. doi:10.1037/0033-2909.131.4.533.
Moitra, E., Christopher, P. P., Anderson, B. J., & Stein, M. D. (2015). Coping-motivated
marijuana use correlates with DSM-5 cannabis use disorder and psychological distress
http://dx.doi.org/10.1037/adb0000083
Monti, J., & Rudolph, K. (2017). Maternal depression and trajectories of adolescent depression:
The role of stress responses in youth risk and resilience. Development and
Muthén, L. K. & Muthén, B. O. (2012). Mplus User’s Guide. Fifth Edition. Los Angeles, CA:
Neppl, T. K., Conger, R. D., Scaramella, L. V., & Ontai, L. L. (2009). Intergenerational
Neppl, T. K., Senia, J. M., & Donnellan, M. B. (2016). The effects of economic hardship:
Testing the family stress model over time. Journal of Family Psychology, 30, 12-21.
doi:10.1037/fam0000168
Park, J, Kosterman, R., Hawkins, J. D., Haggerty, K. P., Duncan, T. E., Duncan, S. C., & Spoth,
R. (2000). Effects of the preparing for the drug free years curriculum on growth in
alcohol use and risk for alcohol use in early adolescence. Prevention Science, 1, 125–138.
doi: 10.1023/a:1010021205638
generational prospective study of an at-risk sample. Child Abuse and Neglect, 25, 1439–
1461. https://doi.org/10.1016/S0145-2134(01)00286-1
Pedrelli, P., Shapero, B., Archibald, A., Dale, C. (2016). Alcohol use and depression during
Peirce, R. S., Frone, M. R., Russell, M., Cooper, M. L., & Mudar, P. (2000). A longitudinal
model of social contact, social support, depression, and alcohol use. Health Psychology,
Pogarsky, G., Thornberry, T. P., & Lizotte, A. J. (2006). Developmental outcomes for children
3737.2006.00256.x
Polderman T.J., Benyamin B., De Leeuw C.A., Sullivan P.F., Van Bochoven A., Visscher P.M.,
& Posthuma D. (2015). Meta-analysis of the heritability of human traits based on fifty
Rothenberg, W. A., Hussong, A. M., & Chassin, L. (2018). Intergenerational continuity in high
Rueter, M. A., Holm, K. E., Burzette, R., Kim, K. J., & Conger, R. D. (2007). Mental health of
007-9082-y
Scaramella, L. V., Neppl, T. K., Ontai, L. L., & Conger, R. D. (2008). Consequences of
http://dx.doi.org/10.1037/a0013190
Simons, R. L., Whitbeck, L. B., Conger, R. D., & Wu, C. I. (1991). Intergenerational
http://dx.doi.org/10.1037/0012-1649.27.1.159
34
INTERGENERATIONAL TRANSMISSION OF SUBSTANCE USE
Spoth, R. L., Trudeau, L., Guyll, M., Shin, C., & Redmond, C. (2009). Universal intervention
effects on substance use among young adults mediated by delayed adolescent substance
10.1037/a0016029
Stein A., Pearson R. M., Goodman S. H., Rapa E., Rahman A., McCallum M., et al. Pariante C.
M. (2014). Effects of perinatal mental disorders on the fetus and child. The Lancet, 384,
1800–1819. https://doi.org/10.1016/S0140-6736(14)61277-0
Stormshak, E. A., Connell, A. M., Véronneau, M.-H., Myers, M. W., Dishion, T. J., Kavanagh,
8624.2010.01551.x
Tarter, R. E., Kirisci, L., Reynolds, M., Horner, M., Zhai, Z., Gathuru, I., & Vanyukov, M.
during drug use and development of substance use disorder. Journal of Addiction
Thompson, K., Stockwell, T., Leadbeater, B., & Homel, J. (2014). Association among different
measures of alcohol use across adolescence and emerging adulthood. Addiction, 109,
Thornberry, T. P., Freeman-Gallant, A., & Lovegrove, P. J. (2009). The impact of parental
Trim, R. S., Meehan, B. T., King, K. M., & Chassin, L. (2007). The relation between adolescent
substance use and young adult internalizing symptoms: Findings from a high-risk
http://dx.doi.org/10.1037/0893-164X.21.1.97
Turrisi, R., Mallett, K. A., Cleveland, M. J., Varvil-Weld, L., Abar, C., Scaglione, N., &
Windle, M. & Wiesner, M. (2004). Trajectories of marijuana use from adolescence to young
https://doi.org/10.1017/S0954579404040118
Wood, M. D., Fairlie, A. M., Fernandez, A. C., Borsari, B., Capone, C., Laforge, R., &
Yap, M. B. H., Cheong, T. W. K., Zaravinos-Tsakos, F., Lubman, D. I., & Jorn, A. F. (2017).
https://doi.org/10.1111/add.13785