SG Curriculum3rd

STUDENT STUDY GUIDE
Integrated Modular System

3rd Professional MBBS Liaquat University
of Medical & Health Sciences,
Academic Year 2023-24 Jamshoro
1
Table of Contents
P R E F A C E .............................................................................................................................................. 4
STUDY GUIDE ........................................................................................................................................... 6
A B B R E V I A T I O N S .......................................................................................................................... 7
C O N T R I B U T I O N S .......................................................................................................................... 8
1 FOUNDATION & GENETICS II ............................................................................................................ 11
Duration ................................................................................................................................................. 11
Learning Outcomes ................................................................................................................................. 11
Themes ................................................................................................................................................... 11
Topics with specific learning objectives and teaching strategies .............................................................. 12
2 INFECTIOUS DISEASE MODULE........................................................................................................ 14
Introduction ............................................................................................................................................ 14
Duration: ................................................................................................................................................ 14
Learning Outcomes ................................................................................................................................. 14
Themes ................................................................................................................................................... 14
Blueprint of Assessment ......................................................................................................................... 21
3 HEMATOLOGY MODULE-II ................................................................................................................ 22
Introduction ............................................................................................................................................ 22
Duration: ................................................................................................................................................ 22
Learning outcomes.................................................................................................................................. 22
Cognitive domain ................................................................................................................................... 22
Themes ................................................................................................................................................... 23
4 RESPIRATORY MODULE-II................................................................................................................. 31
Introduction ............................................................................................................................................ 31
Duration: ................................................................................................................................................ 31
Themes ................................................................................................................................................... 32
5 CARDIOVASCULAR MODULE-II ....................................................................................................... 37
Introduction ............................................................................................................................................ 37
Duration: ................................................................................................................................................ 37
Themes ................................................................................................................................................... 38
6 GASTROINTESTINAL TRACT & LIVER MODULE II........................................................................ 43
Introduction ............................................................................................................................................ 43
2
Duration: ................................................................................................................................................ 43
Themes ................................................................................................................................................... 43
7 ENDOCRINOLOGY MODULE II .......................................................................................................... 52
Introduction ............................................................................................................................................ 52
Duration: ................................................................................................................................................ 52
Themes ................................................................................................................................................... 53
8 RENAL/ EXCRETORY SYSTEM MODULE-II ..................................................................................... 59
Introduction ............................................................................................................................................ 59
Duration: ................................................................................................................................................ 59
Themes ................................................................................................................................................... 59
9 REPRODUCTIVE SYSTEM MODULE-II ............................................................................................. 63
Introduction ............................................................................................................................................ 63
Duration: ................................................................................................................................................ 63
Themes ................................................................................................................................................... 63
10 MUSCULOSKELETAL MODULE-II ................................................................................................... 67
Introduction ............................................................................................................................................ 67
Duration: ................................................................................................................................................ 67
Themes ................................................................................................................................................... 67
11 NEUROSCIENCE II ............................................................................................................................. 70
............................................................................................................................................................... 70
Introduction ............................................................................................................................................ 70
Duration: ................................................................................................................................................ 70
Themes ................................................................................................................................................... 70
11 EXAMINATION ASSESSMENT ......................................................................................................... 72
11 LEARNING RESOURCES ................................................................................................................... 72
3
PR E FAC E
The MBBS curriculum is designed to prepare the medical student to assume the role of the principal
carer for patients. The majority of instruction in the various basic and clinical science disciplines is
focused on attaining this objective. The amount of material and specificity that the student must
acquire in order to complete the MBBS programme as a whole is substantial. Subject-based
instruction affords students the chance to develop comprehensive and profound understanding of
each respective subject. However, this instructional framework might result in the student failing to
recognize the interconnectedness of knowledge across different disciplines, their interrelation, and
most significantly, their significance in the context of patient care.
Over the years, numerous inventive approaches have been devised to tackle these obstacles. One
such approach is the integration of instruction at multiple levels, which eliminates and reduces
boundaries within subjects, both vertically and horizontally, across phases. LUMHS, while
acknowledging the merits of these methodologies, has endeavoured to seize the opportunity to
comprehend the interdependencies and minimize duplication in the subjects being instructed through
the implementation of an integrated modular approach.
The cardiovascular system, musculoskeletal system, and respiratory system are few examples of
system-based modules in an integrated modular curriculum that connects basic scientific knowledge
to clinical problems. By means of integrated instruction, subjects are presented as a unified whole.
Students can enhance their comprehension of basic scientific principles through consistent
application of clinical examples in their learning. A skills lab provides early exposure to the acquisition
of skills, case-based discussions, and self-directed learning are all elements of an integrated teaching
programme.
LEARNING STRATEGIES
The following instructional and learning strategies are implemented to foster greater comprehension:
 Interactive Lectures
 Small group sessions
 Case-Based Learning (CBL),
 Self-Study,
 Practical,
 Skills lab sessions,
 Demonstrations
 Field visits
INTERACTIVE LECTURES
In large group, the lecturer actively involves the students by introducing the topic or common clinical
conditions and explains the underlying phenomena by questions, pictures, videos of patients’
interviews, exercises, etc. in order to enhance their learning process.
SMALL GROUP TEACHING (SGT):

This strategy is helpful for the students to make their concepts clear, and s acquiring skills or attitudes.
These sessions are organized with the help of specific tasks such as patient case, interviews or
discussion topics. Students are than encouraged to exchange their ideas and apply knowledge
gained from lectures, tutorials and self-study. The facilitator employs probing questioning,
summarization, or rephrasing techniques to enhance the understanding of concepts.
CASE- BASED LEARNING:

A format of small group discussion that centres on a sequence of questions derived from a clinical
scenario, with the aim of facilitating learning. Students engage in discussions and provide answers
by applying pertinent knowledge acquired in clinical and basic health sciences throughout the
curriculum.
4
PRACTICAL:
Basic science practical related to anatomy, biochemistry, pathology, pharmacology and physiology
are scheduled to promote student learning by application.
SKILLS LAB SESSION:

Skills relevant to respective module are observed and practiced where applicable in skills laboratory.
SELF DIRECTED LEARNING:

Students take on the responsibility of their own learning by engaging in independent study,
collaborating and talking with classmates, accessing knowledge from the Learning Resources
available, teachers, and other experts. Students can make use of the designated self-study hours
provided by the college.
FIELD VISITS:
Students visit community health areas to understand the common diseases and their preventive
measures.
HOSPITAL POSTINGS:
Students attend tertiary care hospital postings and learn common diseases and their management.
Prof. Dr. Samreen Memon

Module Coordinator
Director Academics
Liaquat University of Medical & Health Sciences,
Jamshoro, Pakistan
5
STUDY GUIDE
A study guide is a strategic and effective approach to:
 Provide students a detailed framework of the modules organization

 Support students in organising and managing their studies throughout academic year.
 Provide students information on assessment methods and the rules and regulations that apply.
 It outlines the outcomes which are expected to be achieved at the end of each module.
 Ascertains the education strategies such as lectures, small group teachings, demonstration,
tutorial and case based learning that will be implemented to achieve the module objectives.
 Provides a list of learning resources for students in order to increase their learning.
 Emphasizes information on the contribution of attendance, end module tests, block examinations
and annual examinations on the student’s overall performance.
 Includes information on the assessment methods that will be held to determine every student’s
achievement of objectives.
6
AB B R E V IATI ONS
FOUNDATION Fnd
HAEMATOLOGY Hem
INFECTIOUS DISEASE ID
RESPIRATORY RESP
CARDIOVASCULAR CVS
GASTROINTESTINAL TRACT & LIVER GIL
NEUROSCIENCE NS
MUSCULOSKELETAL MSK
ENDOCRINOLOGY End
RENAL & EXCRETORY EXC
REPRODUCTIVE Rep
PATHOLOGY Path
PHARMACOLOGY Pharm
MEDICINE Med
SURGERY Surg
PAEDIATRICS Paeds
COMMUNITY MEDICINE CM
SPIRAL S
MICROBIOLOGY Micb
7
CONTRIBUTIONS
Prof. Dr. Ikram din Ujjan

Vice-Chancellor
Jamshoro, Pakistan
Prof. Dr. Munawar Alam Ansari
Dean
Faculty of Basic Medical Sciences
Jamshoro, Pakistan
Prof. Dr. Moin Ahmed Ansari
Dean
Faculty of Medicine & Allied Sciences
Jamshoro, Pakistan
Prof. Dr. Ashok Kumar Narsani
Dean
Faculty of Surgery & Allied Sciences
Jamshoro, Pakistan
Prof. Dr. Samreen Memon
Module Coordinator
Director Academics
Chairperson, Department of Anatomy
Jamshoro, Pakistan
Dr. Hudebia Allah Buksh
Incharge, Department of Medical Education
Jamshoro, Pakistan
Dr. Nazia
Assistant Professor, Department of Pathology
Bilawal Medical College for Boys
Directorate of Academics
Jamshoro, Pakistan
Dr. Faheem Ahmed Memon

Lecturer, Department of Pathology
Jamshoro, Pakistan
Dr. Sameena Gul

Associate Professor
Department of Anatomy, Bilawal Medical College for Boys
Jamshoro, Pakistan
8
Prof. Dr. Rano Mal
Department of Medical Education, Bilawal Medical College for Boys
Jamshoro, Pakistan
Administrative Staff
Mr. Mohal Lal

Sr. Data Processing Officer
Vice-Chancellor’s Secretariat
Jamshoro, Pakistan
Mr. Syed Zohaib Ali
Assistant Network Administrator
Vice-Chancellor’s Secretariat
Jamshoro, Pakistan
Mr. Mazhar Ali
Jamshoro, Pakistan
Faculty
DEPARTMENT OF PATHOLOGY
S# TEACHING FACULTY
VICE CHANCELLOR LUMHS/ PROFESSOR:
01 Prof. Ikram Din Ujjan
PROFESSOR AND CHAIRMAN
02 Dr. Abid Hussain Chang
ASSOCIATE PROFESSOR
03 Dr. Tanweer Ahmed Shaikh
04 Dr. Abdul Aziz Shaikh
05 Dr. Kiran Amir
06 Dr. Naila Shaikh
ASSISTANT PROFESSORS
07 Dr. Zahida Shaikh
08 Dr. Muhammad Rahil Khan
09 Dr. Arshi Naz
10 Dr. Abdul Rehman Khalil
11 Dr. Yousra Shafquat
LECTURERS
12 Dr. Khalil Ahmed Memon
13 Dr. Khalid Yousuf Memon
14 Dr. Shabnum Rustamani
15 Dr. Muhammad Ali Memon
16 Dr. Faheem Memon
17 Dr. Furqan Ahmed Bhatti
18 Dr. Aamir Ramzan
19 Dr. Sadia Akbar
9
20 Dr. Sorath Sindhu
21 Dr. Sidra Qadir
22 Dr. Rameez Iqbal
23 Dr. Yasmeen Rasheed
DEPARTMENT OF PHARMACOLOGY
S# TEACHING FACULTY
PROFESSOR /DEAN BASIC MEDICAL SCIENCES
01 Prof. Munawar Alam Ansari
ASSOCIATE PROFESSOR / CHAIRMAN :
02 Dr. Jamil Laghari
ASSOCIATE PROFESSOR:
03 Dr. Mashkoor Ansari
ASSISTANT PROFESSOR :
04 Dr. Gunesh Kumar
05 Dr. Sadat Memon
LECTURERS
06 Dr. Shamshad Memon
07 Dr. Adeela Mangrio
08 Dr. Rizwan Memon
09 Dr. Fazeela Memon
10 Dr. Naveea Bai
DEPARTMENT OF COMMUNITY MEDICINE

S# TEACHING FACULTY
PROFESSORS
01 Dr. Aneela Atta Ur Rahman
02 Dr. Muhammad Ilyas Siddiqui
ASSOCIATE PROFESSOR
03 Dr. Shazia Rahman Shaikh
04 Dr. Gulzar Usman
05 Dr. Ambreen Aziz Sahito
ASSISTANT PROFESSORS
06 Dr. Suhail Ahmed Bijarani
07 Dr. Tariq Feroze
08 Dr. Faiza Memon
LECTURERS
09 Dr. Wali Muhammad Nizamani
10 Dr. Farah Deeba Shaikh
11 Dr. Zoheb Rafique
12 Dr. Sindhia Javaid Junejo
13 Dr. Rafaina Shah
14 Dr. Kanwal Naz
15 Dr. Sindhu Almas
10
1 FOUNDATION & GENETICS-II
Introduction
Welcome to the Foundation II module. This exciting module will serve as building block and is very essential
to your future work as doctors. This module is designed to make your learning both interesting and productive
by including several inter active activities.
This module marks the beginning of transition to more focus on clinical learning. This module will introduce
students to key concepts essential for understanding diseases process, their prevention and treatment.
Students will be able to apply these key concepts in future, system-based modules to understand the
diseases processes and their management. This module will deal with cell pathology, Genetics and
Hemodynamics. The course covers the molecular level of cell biology including genetics and its role in
pathology.
Rationale
This module will enable the students of third year to recognize the basics of general pathology. The student
will develop the understanding of the cell pathology, genetic diseases and their diagnosis and diseases due
to disturbance of hemodynamics. Concepts dealt with in this module will be revisited in other modules in the
future
Duration
02 weeks
Learning Outcomes
At the end of this module students should be able to:
 Define Pathology and Pathogenesis and discuss cellular Responses to the injury and stages of
the cellular Response to stress and injurious stimuli.
 Discuss morphological alterations in cell injury including both reversible and irreversible injury
 Discuss causes, morphological and biochemical changes, clinic-pathologic correlations in
Apoptosis and Necrosis
 Define edema, effusion, exudate, transudate, hyperemia and congestion.
 Describe the clinical manifestations & consequences of pulmonary & systemic thromboembolism
 Describe the mechanism of three major types of shock and Describe the three stages of shock
 Discuss the transmission pattern of single gene disorder
 Discuss chromosomal abnormalities and define normal karyotype and common cytogenetic
terminology
Themes
Theme 1: Cell Pathology and Genetics
Theme 2: Hemodynamics
11
TOPICS WITH SPECIFIC LEARNING OBJECTIVES AND TEACHING
STRATEGIES
Theme 1: Cell Pathology and Genetics
TEACHING
S. # LEARNING OBJECTIVES TOPIC ASSESSMENT
STRATEGY
Pathology
 Enumerate causes of Cell Injury
 Discuss types of cell injury
Fnd-S2-Path-1
1  Describes sequential Cell injury
morphologic changes in Cell
Injury
 Define Necrosis and its type
2  Describe the nuclear and Fnd-S2-Path-2
cytoplasmic features of Necrosis
necrosis.
 Define Apoptosis Enumerate
pathological and
physiological causes of Fnd-S2- Path-3
3
Apoptosis Apoptosis
 Describe Biochemical Features
and Mechanism of Apoptosis
 Define and describe
Fnd-S2- Path-4
pathological calcification.
4 Calcification and
 Discuss Dystrophic and Interactive
SBQs & OSVE
Pigmentation Lecture
metastatic calcification
 Define Mutation and its type.
Fnd-S2-Path-5
5  Describe the effects of different
Mutations
types of mutations
 Define Mendelian Disorder
 Explain the pattern of
inheritance in Mendalian Fnd-S2-Path-6
6 Disorders Mendelian
 List the examples of autosomal, Disorders
Recessive and sex linked
disorders.
 Describe normal Karyotype
Fnd-S2-Path-7
7  Discuss various numerical and Chromosomal
structural abnormalities of aberration.
chromosomes.
Fnd-S1- Path-8
 Discuss various technique in
8 Diagnosis of
diagnosis of genetic diseases.
Genetic Diseases
 Define Hypertrophy,
Hyperplasia, Atrophy and
Metaplasia. Fnd-S2-Path-9
9 Practical OSPE &OSVE
 Demonstrate gross and Cellular adaptation
microscopic features of cellular
adaptations
12
Theme 2: Hemodynamics
TEACHING
STRATEGY
Pathology
 Define edema
Fnd-S2-Path-10
10  Describe Pathophysiology of
Edema
edema
 Define Hemorrhage, Hyperemia,
Fnd-S2-Path-11
Congestion
11 Hyperemia,
 Describe their causes and
Congestion
pathophysiology
 Define Shock Interactive
Fnd-S2-Path-12 SBQs & OSVE
12  Describe the pathophysiology of Shock Lecture
different type of Shock.
 Define Infarction
 Discuss the etiology of infarction
13  Discuss the morphological Fnd-S2-Path-13
classification of infarcts Infarction
 Describe the morphological
features of infarctions.
 List and define causes of
intracellular accumulation Fnd-S2-Path-14
14  Discuss the role of Intracellular Intracellular Practical OSPE & OSVE
Accumulations in metabolic Accumulations
derangements of cell.
Subject in Module Proportion

of subjects Weightage Test Instrument/tool/method Explanation
in module
What to assess? How to assess?
MCQs OSVE OSPE/ Any Proportion of test
(SBQs) stations OSCE Other instruments to be
Level 1 & 2 Level 1 Level 3 used:
&2 Theory
Pathology 14 14 14 MCQs (SBQs)=
100 %;
Practical
OSVE=80%
OSPE/OSCE= 20%
Competency level
& Learning
Domain at Miller’s
Pyramid:
Cognition:
Know (Level-1)&
How to know
(Level-2)
Skills & Attitude:
Show (Level-3) &
Does (Level-4)
14 14 14 80% 20%
13
2 INFECTIOUS
INFECTIOUS DISEASE MODULE
DISEASE MODULE
Introduction
Infectious diseases remain a serious public health problem in the 21st century. WHO has classified Infectious
diseases as the second leading cause of death with approximately 15 million deaths worldwide every year.
HIV/AIDS, tuberculosis, and malaria have been nicknamed the ‘big three’ because of their important impact
on global human health.
At home, the story is no different. Pakistan is one of several countries, which together bear 95% of the burden
of infectious diseases. Pakistan is ranked fifth out of twenty-two on the list of high-burden tuberculosis
countries. An alarming average of about one million lives are also claimed yearly by malaria.1 Worst of all,
Pakistan is one of the two remaining countries where polio is still endemic2. Hence, it is important to spread
knowledge and information on the importance of immunization to the general public. Other factors such as
overcrowding, poor hand washing practices and lack of effective prescriptions contribute to further worsening
the situation. An estimated 32% of general practitioners in Pakistan fail to administer the proper medication
thus increasing the disease burden.
It is therefore important as 3 rd year medical students to enhance your existing knowledge of the prevalent
infectious diseases, and build greater understanding and ability to recognize signs and symptoms, and relate
with appropriate investigations, and therapeutics.
Rationale
Infectious diseases are the most common problems of our community. In the under developed countries,
like Pakistan, infectious diseases along with malnutrition are the commonest causes of mortality. Most of
the diseases are identifiable and curable if recognized early. It is important for medical graduates to have
sound understanding of microbiology of the organisms and the diseases that they cause. Students should
also understand the rationale of the investigations to diagnose these diseases. They should also know the
pharmacology of the various drugs used to treat infectious disease and the rationale to treat the common
diseases.
Duration:
06 weeks
Learning Outcomes
After completion of this module student should be able to:
 Describe pathogenesis & clinical presentations of common bacterial, viral, fungal & microbial
infections.
 Recognize the clinical presentation of common infectious diseases in community.
 Take history & formulate appropriate plan of investigations for attaining differential diagnosis
 Analyze findings of history, examinations & investigations for diagnosis.
 Practice basic principles of management of infectious diseases.
 Recognize preventive measures & prognosis for counseling the patients.
 Be Aware of the prognosis and be able to counsel their patients accordingly.
Themes
Theme 1: Immuno-pathogenesis
Theme 2: Diagnostic Approach to Infection
Theme 3: Pyogenic Bacteria
Theme 5: Pyrexia of Unknown Origin
14
STRATEGIES
Revisit
TEACHING
S. # LEANING OBJECTIVES TOPIC ASSESSMENT
STRATEGY
Pathology
Enlist essential and non-essential ID-S2-Path-1
1 components of a typical bacterial cell with Bacterial
their function Structure
 Classify bacteria on the basis of Gram
staining.
ID-S2-Path-2
 Differentiate characteristics of gram-
Classification of
positive and gram-negative bacteria
2 bacteria & normal
 Define normal flora.
flora (human
 Describe colonization of normal flora. microbiota)
 Name the members of normal flora with
their appropriate anatomical locations
 Define acute inflammation
ID-S2-Path-3
 Describe the sequence of vascular
General features
3 changes Interactive
of inflammation &
 Define exudates and transudate and vascular changes Lecture
SBQs & OSVE
their mechanism of formation
 Describe the acute inflammatory cells
and their functions. ID-S2-Path-4
 Name the various types of chemical Cellular events of
4
mediators & their role Chemotaxis,
 Describe the local and general clinical phagocytosis
features of acute inflammation
 Define chronic Inflammation
 Describe the characteristic features and
types of chronic Inflammation ID-S2-Path-5
5  Define granuloma, mention a etiological Chronic
classification of granuloma with inflammation
examples
Microbiology
 Outline various methods for transfer of ID-S2-Micb-1
6 genetic information in bacterium. Bacterial genetics
 Describe the phases of bacterial growth. & bacterial growth
 State the criteria are used in viral Interactive
ID-S2-Micb-2 SBQs & OSVE
classification Lecture
Classification &
7  Describe the characteristics of DNA and
structure of
RNA viruses
viruses
 Describe structure of virus
To demonstrate the principle & procedure of ID-S2-Micb-3
8 Gram’s staining Gram’s Practical OSPE & OSVE
staining
Pharmacology
ID-S2-Pharm-1
Describe the classification, mechanism of
9 Beta lactam
action & side effects of penicillin’s
antibiotics Interactive
SBQs & OSVE
Describe the classification, mechanism of ID-S2-Pharm-2 Lecture
10 action & side effects of cephalosporin’s & Beta lactam
other cell wall synthesis inhibitors antibiotics
15
Theme 1: Immuno-Pathogenesis
TEACHING
STRATEGY
Microbiology
 Differentiate b/w true
pathogens, opportunists and
commensals
 List the routes of ID-S2-Micb-4
transmission of infection Bacterial
11
 Describe colonization, pathogenesis-I
pathogenesis, spread and
excretion of infectious
agents.
 Differentiate b/w true
pathogens, opportunists and
commensals
 List the routes of ID-S2-Micb-5
12 transmission of infection Bacterial
 Describe colonization, pathogenesis-II
pathogenesis, spread and
excretion of infectious
agents.
 Define viral pathogenesis.
 Describe the effect of virus
infection on host cell. ID-S2-Micb-6
13
 Explain specific and non- Viral pathogenesis Interactive
SBQs & OSVE
specific defense mechanism Lecture
against viral infection.
 Describe host defense
mechanism against bacteria.
ID-S2-Micb-7
 Distinguish between passive
Host defense
14 & active adaptive immunity.
against bacterial
 To discuss the failure of host infection
defense against infections.
 Distinguish between innate

and acquired immunity
 Describe the role of ID-S2-Micb-8
interferons, natural killer Host defense
15
cells, cytotoxic T cell in viral against viral
diseases infection
 Explain how interferons limit
cell-to-cell spread of viruses.
 Describe the steps of viral
replication
ID-S2-Micb-9
16  Explain mode of replication Viral Replication
of various RNA and DNA
viruses.
 Define sterilization and
disinfection ID-S2-Micb-10
 Enlist various methods used Sterilization and
for sterilization and disinfection
disinfection
To demonstrate the principle &
ID-S2-Micb-11
17 procedure of Acid-fast staining. Practical OSPE & OSVE
Acid fast staining
16
Pharmacology
ID-S2-Pharm-3
 Describe classification,
Anti-viral drugs -1 Interactive
17 mechanism of action & side SBQs & OSVE
ID-S2-Pharm-4 Lecture
effects of anti-viral drugs
Anti-viral drugs-2
Theme 2: Diagnostic Approach to Infection

TEACHING
STRATEGY
Microbiology
 Compare and contrast the
various methods used to
diagnose bacterial diseases
 Describe various microscopic ID-S2-Micb-12
18 and culture techniques used Laboratory diagnosis
for diagnosis of bacterial diseases
 Discuss molecular
techniques in diagnosis of
infectious diseases.
 Compare and contrast the
various methods used to
diagnose viral diseases
 Describe various microscopic ID-S2-Micb-13 Interactive
SBQs & OSVE
20 and culture techniques used Laboratory diagnosis Lecture
for diagnosis of viral diseases
 Discuss molecular
techniques in diagnosis of
infectious diseases.
 Distinguish between fungal &
bacterial cell
 Contrast sexual & asexual
reproduction of fungi. ID-S2-Micb-14
21
 Define dimorphism Basic Mycology
 Describe pathogenesis,
fungal toxins and lab
diagnosis of fungi
Classify and explain important
ID-S2-Micb-15
properties, transmission,
Cutaneous, systemic
pathogenesis, clinical findings and
and opportunistic
lab. diagnosis of cutaneous,
mycosis
systemic and opportunistic fungi.
 Classify culture media
 Enlist various ingredients
used for making culture ID-S2-Micb-16
22 Practical OSPE & OSVE
media Culture Media
 Demonstrate selective and
biochemical test media
Pathology
 Define healing, repair and
regeneration
ID-S2-Path-06 Interactive
23  Describe the mechanisms of Healing & Repair Lecture
SBQs & OSVE
primary and secondary
wound heal
17
 Distinguish the differences
between healing by first and
secondary
 intention
 List the local and general
factors influencing healing
 List the complications of
wound healing

TEACHING
STRATEGY
Microbiology
 Enlist the species of Staphylococci
 Enlist the virulence factors & toxins.
 Describe pyogenic and toxin ID-S2-Micb-17
25 mediated diseases caused by
Staphylococci
staphylococcus aureus.
 Discuss lab diagnosis of
staphylococci
 Classify medically important
streptococci
 Describe toxins, enzymes &
hemolysins produced by
ID-S2-Micb-18
26 streptococci. Discuss their
Streptococci
pyogenic, toxigenic & post
streptococcal diseases.
 Describe the lab diagnosis of Interactive
SBQs & OSVE
streptococci. Lecture
Describe morphology, pathogenesis,
ID-S2-Micb-19
27 clinical features and lab diagnosis of
Pneumococci
Pneumococcus.
 Enlist species of Neisseria.
 Describe their morphology, ID-S2-Micb-20
28
pathogenesis and laboratory Neisseria
diagnosis.
 Define Diphtheria & Listeriosis.
 Describe important properties, ID-S2-Micb-21
transmission, pathogenesis of Corynebacterium
29 diphtheria & Listeria. diphtheria &
 Discuss the laboratory diagnosis of Listeria
Corynebacterium diphtheria & monocytogens
Listeria monocytogens.
Describe various microscopic and ID-S2-Micb-22
culture techniques used for diagnosis Lab diagnosis of
gram positive &
negative cocci.
Pharmacology
Describe classification, mechanism of ID-S2-Pharm-5
31 action & side effects of Aminoglycosides Antibiotics-1
Describe classification, mechanism of
ID-S2-Pharm-6 Interactive
32 action & side effects of tetracyclines & SBQs & OSVE
Antibiotics-2 Lecture
chloromphenicol
33 action & side effects of macrolides Antibiotics-3
18
34 action & side effects flouroquinolones Antibiotics-4
Describe classification, mechanism of
ID-S2-Pharm-9
35 action & side effects of sulfonamides &
Antibiotics-5
trimethoprim

TEACHING
STRATEGY
Microbiology
Outline morphology, pathogenesis,
ID-S2-Micb-23
36 clinical features and lab diagnosis of
Bacillus
Bacillus
 Classify clostridia
37  Describe morphology, pathogenesis, ID-S2-Micb-24
clinical features and lab diagnosis of Clostridia
Clostridia
 Enlist pathogenic strains of E. coli
ID-S2-Micb-25
38  Describe morphology, virulence E.coli &
factors, cultural characteristics and Klebsiella
Lab diagnosis of E.coli and Klebsiella Interactive
SBQs & OSVE
 Classify different strains of Lecture
Salmonella & Shigella
 Describe antigenic structure and ID-S2-Micb-26
39 virulence factor of salmonella & Salmonella &
Shigella Shigella
 Discuss lab diagnosis of Salmonella
& shigella
 Enlist various species of proteus and
ID-S2-Micb-27
pseudomonas
40 Proteus &
 Describe pathogenesis and lab Pseudomonas
diagnosis
Describe various microscopic and ID-S2-Micb-28
cultural characteristics used for Lab diagnosis
diagnosis of gram positive
bacilli (rods)
Theme 5: Pyrexia of Unknown Origin

TEACHING
STRATEGY
Microbiology
 Classify the medically important ID-S2-Micb-29
Spirochetes. Spirochetes
 -Describe the important properties, Interactive
42 (Treponema, SBQs & OSVE
transmission & clinical findings. Lecture
Borrelia,
 -Discuss the lab diagnosis of Syphilis Leptospira)
 Define Dengue fever
 Describe vector, life cycle and clinical
ID-S2-Micb-30
manifestation of dengue virus
46 Dengue & polio SBQs & OSVE
 Discuss mode of transmission, virus
pathogenesis and clinical feature of
polio virus
19
 Describe structure of HIV
 Discuss clinical stages of HIV ID-S2-Micb-31
infection
HIV
 Outline opportunistic infection in late
stage of AIDS
 Classify medically important
ID-S2-Micb-32
Trematodes
Trematodes
 Describe life cycle clinical feature and
(Flukes)
lab. diagnosis
 Classify medically important Tissue ID-S2-Micb-33
Nematodes Tissue
 Describe their important properties, Nematodes
clinical findings and lab. diagnosis (Wuchereria,
Onchocerca,
Loa,
Dracunculus)
Describe various microscopic and culture ID-S2-Micb-34
techniques used for diagnosis Lab diagnosis
47 of gram Practical OSPE & OSVE
negative bacilli
(rods)
Pharmacology
Describe the different drug options for ID-S2-Pharm-10
48 treatment of dengue fever Anti-viral drugs
for dengue
fever
Describe the antiviral drugs used for ID-S2-Pharm-11 Interactive
treatment of HIV with their mechanisms Antiretroviral SBQs & OSVE
Lecture
and side effects. drugs
Classify anti helminths drugs with their ID-S2-Pharm-12
mechanism and side effects Anti-parasitic
drugs
Clinical Lectures
Discuss clinical presentations and ID-S2-Med- 1
49
management of Syphilis Syphilis
Discuss clinical presentations & ID-S2-Med-2 Interactive
50 SBQs & OSVE
management of Dengue fever Dengue Fever Lecture
Discuss clinical presentations and ID-S2-Med- 3
management of AIDS AIDS
20
Blueprint of Assessment
Purpose of Assessment: Summative Assessment First Professional MBBS
Curriculum: Integrated Modular Curriculum
Module: Infectious Disease Module
Proportion
Subject in Module of subjects Weightage Test Instrument/tool/method Explanation
in module
(SBQs) stations OSCE Other instruments to be
Level 1 & 2 Level 1 Level 3 used:
&2 Theory
Pathology 06 (7.6%) 08 08 MCQs (SBQs)=
100 %;
Microbiology 34 (43%) 43 43 Practical
Pharmacology 12 (15.18) 15 15 OSVE=80%
OSPE/OSCE= 20%
Community 24 (30.3%) 30 30
medicine Competency level &
Clinical Lecture 03 (3.7%) 04 04 Learning Domain at
Miller’s Pyramid:
Cognition:
Know (Level-1)&
How to know (Level-
2)
Skills & Attitude:
Show (Level-3) &
Does (Level-4)
79 100% 100 80% 20%
21
3 HEMATOLOGY MODULE-II
Introduction
Welcome to the Hematology module-II. This module aims to provide the basic understanding of Cancer,
chemo therapeutic agents and preventive measures. The module is also designed to provide basic
knowledge of hematological diseases to the students in order to deal with various Hematological and
Immuno- Hematological disorders of adults and children. In this regard students will also learn to take history,
examine patients and relevant Laboratory tests, their interpretations, differential diagnosis, treatment
regimens and prognostic values of various disorders.
Rationale
The module will give the 3rd year medical students, an opportunity to know the clinical findings and
management of common hematological, immunological and neoplastic disorders. Students will be expected
to critically think about the clinical scenarios and participate in case-based learning sessions for clearing your
concepts andbetter learning. It will also help you focus your attention on what you need to achievefrom the
lectures, practical and clinical rotation that have been scheduled in this module.
Duration:
05 weeks
Learning Outcomes
The Outcomes of the Hematology Module are as follows:
 Knowledgeable
 Skillful
 Community Heath Promoter
 Problem-solver
 Professional
 Researcher
 Leader and Role Model
Cognitive Domain
 To Describe Neoplasia, its etiology, pathophysiology, molecular basis, diagnosisof cancers and
its therapy.
 Explain the pathophysiology, clinical features and diagnostic approach of various Red cells
disorders.
 Explain the pathophysiology, clinical features and diagnostic approach ofbleeding disorders
 To describe the hemolytic disease of new born (RH, ABO, Minor groupincompatibility).
 To describe the etiology & pathophysiology of lymphadenopathy and hepatosplenomegaly
 To describe the difference Hematological malignancies.
 To describe the transplantation and graft rejection.
 To describe the blood parasites.
 Identify the role of pharmacology (drugs) in anemia and bleeding disorders.
 To describe the Immunosuppressants, immunomodulators related totransplantation
 Role of balanced diet in the prevention of blood disorders in community.
 Recognize the common causes of anemia prevalent in our community
22
Psychomotor Domain
Description of the psychomotor skills to be developed and thelevel of performance required:
 Carry out practical work as instructed in an organized and safe manner.

 Make and record observations accurately.
 General physical examination of patient.
 Interpretation of diagnostic tests for cancer.
 Interpretation of laboratory tests for the diagnosis of Anemia.
 Interpretation of laboratory tests for the diagnosis of Anemia.
 Perform Manual blood grouping by tube method & compatibility testing.
 Interpretation of morphological features and immunohistochemicalresults of Hodgkin and non-
Hodgkin lymphoma.
 Interpretation of laboratory tests for the diagnosis of Acute & ChronicLeukemia.
Attitude & Behaviour

 To give and receive feedback, Respect for self and peers.
 To give sympathy and care to patients.
 Counseling of patients and family members for inherited anemias.
 Counseling of families for prenatal diagnosis of Thalassaemia.
 Counseling of patients and family members for Hematologicalmalignancies.
 Develop communication skills with sense of Responsibility towards patients.
 Demonstrate good laboratory practices
Themes
Theme 1: Oncology
Theme 2: Pallorness (Anaemia)
Theme 3: Hemostatic abnormalities
Theme 4: Lymphadenopathy
Theme 5: Hematological Malignancies
Theme 6: Immunological disorders & Transplantation
23
STRATEGIES
Theme 1: Oncology
TEACHING
STRATEGY
Pathology
 Describe the definition of neoplasia.
1  Describe the nomenclature of Hem-S2-Path-1
neoplasia. Neoplasia
 To describe the Characteristic of

benign & Malignant tumor Hem-S2-Path-2
2  To know Pathways of spread, Characteristic
seeding, lymphatic and Features of Tumor
Hematogenous spread
 Normal cell cycles and
fundamental principal of cancer
regarding cycle
 Essential alterations in malignant Hem-S2-Path-3
3
transformation Molecular Basis of
 Steps of cell proliferation Cancer –I
Protooncogenes and growth factors
andtheir receptors
 Two-hit hypothesis of knudson Interactive
SBQs & OSVE
 Tumor suppressor genes Lecture
 Cellular changes in tumor cells Hem-S2-Path-4
4  DNA repair defects Molecular Basis of
 Homing of tumor cells Cancer -II
 Development of sustained
angiogenesis
 To discuss Epidemiology of
Hem-S2-Path-5
cancers
Carcinogenic
 To discuss different types of
5 Agents
carcinogens
(Radiation
 To discuss the Mechanism of Carcinogenesis)
action ofradiation carcinogen
To discuss the Mechanism of action Hem-S2-Path-6
ofchemical & viral carcinogen. Carcinogenic
6 Agents
(Chemical &Viral
Carcinogenesis)
 To discuss Clinical features of
cancer.
Hem-S2-Path-7
 To discuss Grading and staging
7 Diagnostic Practical OSPE & OSVE
ofcancer.
approach of
 To discuss diagnostic methods Neoplasia
used forCancer.
Microbiology
 Classify the tumor Viruses
 Describe the role of tumor viruses
inmalignant transformation. Hem-S2-Micb-1 Interactive
8 SBQs & OSVE
 Discuss the mechanism involved Tumor Viruses Lecture
incarcinogenesis.
24
Pharmacology
 Classify the Anticancer Drugs.
9  Describe the mechanism of Hem2-S2-Pharm-1
action, indication, adverse effects, Anti-cancer Drugs-I
drug-druginteractions.
 Describe the mechanism of Interactive
SBQs & OSVE
resistanceof Anticancer Drugs. Lecture
10  Describe the general Hem2-S2-Pharm-2
principles of combination Anti-cancer Drugs-II
chemotherapy in treatment of
cancer
Theme 2: Pallorness (Anaemia)

TEACHING
STRATEGY
Pathology
 To enlist the causes, clinical
features Hem-S2-Path-8
11  and laboratory diagnosis of iron Nutritional
deficiency & Megaloblastic Anemias
anemias.
 To Enlist the causes,
pathogenesis, clinical features and Hem-S2-Path-9
12
laboratory diagnosis of Aplastic Aplastic anemia
anemia.
 To discuss the pathogenesis,
clinical features and laboratory
Hem-S2-Path-10
13 diagnosis of Hereditary
Hemolytic Anemia
spherocytosis & G6P Interactive
Ddeficiency SBQs & OSVE
Lecture
 To explain pathogenesis of
Hemoglobinopathies. Hem-S2-Path-11
14  To identify morphological features Hemoglobinopathi
onperipheral blood smear. es
 Define Malaria and classify
malarialparasites.
 Describe life cycle of malarial
parasites. Hem-S2-Micb-2
15
 Differentiate between Benign and Plasmodium
Malignant Tertian malaria.
 Discuss complications of
PlasmodiumFalciparum.
 Interpretation of CBC.
 To discuss the Peripheral film Hem-S2-Path-12
16 findingsof different types of anemia. Laboratory diagnosis Practical OSPE & OSVE
 To discuss the different tests used of Anemia
forthe diagnosis of Anemia.
 Classify the drugs used in Iron Hem-S2-Pharm-3 Interactive
17 SBQs & OSVE
Deficiency Anemia Oral & injectable Lecture
25
 Describe the Mechanism Of Action, iron deficiency
Indications, Contraindications, anemia
Adverse Effects And Drug
Interactions Of Various Drugs used
to treat the IronDeficiency Anemia
 Classify the drugs used in Vitamin
B12 and Folic Acid Deficiency
Anemia.
Hem-S2-Pharm-4
 Describe the Mechanism of Action, Vit. B12 & Folic
18  Indications, Contraindications, acid in Macrocytic Interactive
Adverse Effects And Drug SBQs & OSVE
anemia Lecture
Interactions of Various Drugs used
to treat the B12 and Folic Acid
Deficiency Anemia
 Classify anti-malarial drugs with Hem-S2-Pharm-5
19
theirmechanism and side effects Anti-malarial drugs
Clinical lecture
Assess, classify and manage childwith Hem-S2-Paeds-1
Interactive
20 anemia Anaemia in SBQs & OSVE
Lecture
children
Theme 3: Hemostatic Abnormalities

TEACHING
STRATEGY
Pathology
 Overview of normal Hemostatsis
 Discuss Quantitative & Qualitative Hem-S2-Path-13
21 plateletsdisorders. Platelets
 To discuss ITP and diagnosis. disorders
 Define & enlist the causes

microangiopathic hemolytic
anemias Hem-S2-Path-14
 Define & explain Thrombotic MAHA
22 Thrombocytopenic Perpura (TTP) (Microangiopathic
and Hemolytic Ureamic Syndrome hemolytic
(HUS) anemia)
 Define and explain Dissemminate
Intravascular Coagulopathy (DIC) Interactive
 Overview of inherited & acquired SBQs & OSVE
Lecture
coagulation disorders
Hem-S2-Path-15
 Discuss the pathogenesis and
Coagulation
pathophysiology of hemophilia A &
23 disorders
B, VWD.
(Hemophilia,
 Diagnose hemophilia based on vWD)
clinical features and laboratory
findings
 To discuss the thrombosis,
pathogenesis, types and fate of
Hem-S2-Path-16
thrombosis.
24 Thromboembolis
 To Define Embolism, its types and m
morphological features of
Embolism.
 Discuss and perform different Hem-S2-Path-17
25 laboratory tests for diagnosis of Laboratory Practical OSPE & OSVE
bleeding disorders diagnosis of
26
Bleeding
disorders
 Classify the coagulants drugs.
 Describe the mechanism of action,
Hem-S2-
clinical
26 Pharm-5
 uses, adverse effects, drug The Coagulants
interactions and contraindications
of the coagulant drugs.
 Classify the Anticoagulants drugs.
Hem-S2-Pharm- Interactive
clinical uses, adverse effects, drug SBQs & OSVE
27 6 Lecture
interactions and contraindications
Anti-Coagulants
of the Anticoagulant
 drugs.
 Classify the thrombolytic drugs.
 Describe the mechanism of action, Hem-S2-Pharm-7
28 clinical uses, adverse effects, drug Thrombolytic
interactions andcontraindications of drugs
the Thrombolytic drugs.
Clinical Lectures
Discuss approach to apatient with Hem-S2-Med-1
Thrombotic disorders Approach to a
29 patient with
Thrombotic
disorders
Interactive
Discuss approach to a patient with Hem-S2-Paeds-2 SBQs & OSVE
Lecture
30 inheritedbleeding disorders Bleeding
disorders
Discuss approach to apatient with Hem-S2-Surg-1
31 deep vein thrombosis Deep Venous
Thrombosis
Theme 4: Lymphadenopathy
TEACHING
STRATEGY
Pathology
 Describe lymphoma, its etiology &
classification. Hem-S2-Path-18
32  Discuss the pathogenesis, types & Hodgkin
morphological features of Hodkin Lymphoma
lymphoma
 Describe Non-hodgkins lymphoma
 The classification and staging of
non hodgkins lymphomas. Hem-S2-Path-19
33
 Discuss the pathogenesis, clinical Non-Hodgkin Interactive
SBQs & OSVE
features and diagnosis of Chronic Lymphoma-I Lecture
lymphocytic leukemia
Brief Discussion of Burkitt,follicular Hem-S2-Path-20
34 and DLBCL lymhoma. Non-Hodgkin
Lymphoma-II
Discuss the pathogenesis, clinical
features and laboratory diagnosis of Hem-S2-Path-21
35
Multiple Myeloma Multiple Myeloma
27
 To see the Morphological features, Hem-S2-Path-22
36  Immunohistochemical findings of Practical approach
Practical OSPE & OSVE
Lymphoma towards
lymphoma
Clinical lectures
Discuss approach to a patient with Hem-S2-Med-2
lymphadenopathy with or without Approach to
Splenomegaly patientwith
37
lymphadenopathy
with or without
splenomegaly Interactive
Discuss approach to Lymphedema Hem-S2-Med-3 SBQs & OSVE
38 Lecture
Lymphedema
Discuss approach to Disorders of Hem-S2-Surg-2
Spleen & Splenectomy Disorders of
39
Spleen &
Splenectomy
Theme 5: Hematological Malignancies

TEACHING
S. # LEARNING OBJECTIVES TOPIC Assessment
STRATEGY
Pathology
 Overview & classification of
acute leukemias Hem-S2-Path-23
40  Describe the pathogenesis, clinical Acute Myeloid
 features and laboratory diagnosis of leukemia
Acute Myeloid leukemia.
 Describe the pathogenesis, clinical Hem-S2-Path-24
41  features and laboratory diagnosis of Acute Interactive
SBQs & OSVE
Acute Lymphoblastic leukemia. Lymphoblastic Lecture
Leukemia
 The classification of
Myeloproliferative disorders Hem-S2-Path-25
42  Discuss the pathogenesis, clinical Myeloproliferative
 features and laboratory diagnosis of disorders
Chronic myeloid Leukemia.
 Morphological features of acute & Hem-S2-Path-26
chronic leukemia. Laboratory
43 diagnosis Practical OSPE & OSVE
of Acute & Chronic
Leukemia
Medicine
 Describe the clinical features, Hem-S2-Med-4
laboratory investigations of acute & Approach to
Interactive
44 chronic leukemia. patientwith Acute SBQs & OSVE
Lecture
& chronic
Leukeimas
28
Theme 6: Immunological Disorders
TEACHING
STRATEGY
Pathology
 Define hypersensitivity reaction
 Describe Pathogenesis of four Hem-S2-Path-27
45 types of hypersensitivity reactions Hypersensitivity
with examples. Reactions
 Discuss immunodeficiency and its Hem-S2-Path-28
46 causes and clinical features. Immunodeficiency
disorders
 Discuss tolerance.
 Define Autoimmune disorders Hem-S2-Path-29
47  Describe the etiology, Autoimmune
Pathogenesis and clinical features Disorders
 of autoimmune disorders.
 Definition of Transplantation Interactive
 Types of transplantation Lecture
SBQs & OSVE
 Sources of bone marrow Hem-S2-Path-30
48 Transplantation &
transplantation.
 Define Rejection & mechanism of Rejection
different types of rejections.
 Define hemoflagellates.
 Enumerate the medically important
species of Leishmania &
Trypanosoma. Hem-S2-Micb-3
49  Describe vector, life cycle, Trypanosoma &
pathogenesis clinical manifestation Leishmania
and lab diagnosis
 of Leishmaniasis &
Trypanosomiasis.
 Discuss the immunoassay Hem-S2-Path-31
50 techniques Immunoassay Practical OSPE & OSVE
technique
Pharmacology
 Classify Antihistamine agents.
 Describe the Mechanism of Action, Hem-S2-Pharm-7
52
Indications, Adverse Effects And Anti-Histamine
Drug Interactions of Antihistamines
 Classify the Immunosuppressant Interactive
SBQs & OSVE
and Immunomodulating drugs. Lecture
Hem-S2-Pharm-8
Immuno
indications & adverse effects of modulatingdrugs
Immunosuppressant and
Immunomodulating drugs.
Clinical Lecture
 Describe the clinical features, Hem-S2-Med-5
laboratory investigations of Approach to
Interactive
53 autoimmune disorders patientwith SBQs & OSVE
Lecture
Autoimmune
disorders
29
Module: Haematology Module
Proportion of
Subject in Module subjects in Weightage Test Instrument/tool/method Explanation
module
(SBQs) stations OSCE Other instruments to be used:
Level 1 Level 1 & Level 3
&2 2 Theory
Pathology 31 (65.9%) 66 66 MCQs (SBQs)= 100 %;
Practical
Microbiology 03 (6.3%) 06 06 OSVE=80%
Pharmacology 08 (17.0%) 17.0 17 OSPE/OSCE= 20%
Community 00 00 00 Competency level &

medicine Learning Domain at
Clinical Lecture 05(10.6%) 11 11 Miller’s Pyramid:
Cognition:
Know (Level-1)& How to
know (Level-2)
Skills & Attitude:
Show (Level-3) & Does
(Level-4)
47 100% 100 80% 20%
30
4 RESPIRATORY MODULE-II
Introduction
This sensational module will be very necessary to your future work as doctors. This module is designed to
make your learning both interesting and productive by including interactive activities. This module provides
basic understanding by integrating the teaching of the basic pharmacology, pathology related to the disorders
of the Respiratory system and their relevant clinical applications (Horizontal Integration). And Forensic
Medicine, Community medicine (Vertical Integration). By adopting this approach, we are preparing you better
for your future work as doctor, where patients will come to you with problems that are not categorized by
discipline name. In order to help you learn in an integrated manner, we have updated the learning of basic
sciences around a few key health-related situations (real life situations), which you are likely to encounter as
third year medical students. You will be expected to think about the scenarios and participate in case based
learning sessions for clearing your concepts and better learning. It will also help you focus your attention on
what you need to achieve from the lectures, practical and tutorials that have been scheduled during this
module.
Rationale
Diseases of the Respiratory system are common all over the world. Timely diagnosis and management of
acute Respiratory problems like Asthma, COPD prevents morbidity and mortality. Early diagnosis and prompt
treatment of Asthma and COPD disease is important to reduce the occurrence of disability burden on
community. Understanding the structure and function of Respiratory system and its relationship with
pathophysiology of diseases is essential for diagnosis and management.
Duration:
03 weeks
Learning Outcomes
Knowledge:
At the end of this module, the students will be able to:
 Explain obstructive and restrictive pathologies involving respiratory system
 Describe the management of the respiratory diseases
 Perform the respiratory system examination
 Take the history of the patients and co-relate the respiratory sign & symptoms to reach
the differential diagnosis
 To counsel the people in community regarding the risk factors of the respiratory
diseases.
Skills
 Microscopic identification of the different diseases of the respiratory system.
 Perform the cardiopulmonary resuscitation(CPR)
 Interpretation of ABGs,PFT
 Perform clinical examination of the respiratorysystem
31
Attitude
 Follow the basic laboratory protocols
 Participate in class and practical work professionally
 Communicate effectively in a team with pears, staff and teachers
 Demonstrate professionalism and ethical values in dealing with patients, pears, staff
and teachers.
 Communicate effectively in a team with pears and teachers.
 Demonstrate the ability to reflect on the performance.
Themes
Theme 1: Lung Injury, Edema, Collapse & Obstructive Pulmonary diseases
Theme 2: Chronic diffuse Interstitial/Restrictive Lung diseases
Theme 3: Infectious & pleural diseases
Theme 4: Lung Tumors

STRATEGIES
Theme 1: Lung Injury, Edema, Collapse & Obstructive Pulmonary
Diseases
TEACHING
STRATEGY
Pathology
 Types & causes of
Atelectasis
 Types & causes of pulmonary
edema
 Define acute lung injury RESP-S2-Path-1
1  Describe the causes of ARDS Pulmonary Edema,
 Discuss the characteristic ARDS & Atelectasis
features, morphology and
pathogenesis of ARDS
 Describe its consequences
and clinical course
 Define Obstructive lung
disease (OPD)
RESP-S2-Path-2
 Classify types of OPD Interactive
SBQs & OSVE
Obstructive lung
2  Describe etiology diseases-I
Lecture
pathogenesis & clinical
features of chronic bronchitis
+ emphysema
 Describe categories of
ASTHMA
 Explain pathogenesis
 Discuss the immunological
RESP-S2-Path-3
mechanisms of bronchial
3 Obstructive lung
asthma and its triggering
diseases-II
factors -Gross features &
morphological Features
 Define BRONCHIECTASIS
 Describe its causes,
32
 Pathogenesis and Gross &
morphological features
 Describe major categories
 Explain the pathogenesis,
morphology and clinical RESP-S2-Path-4
course of its important types Restrictive lung
diseases
4  Idiopathic pulmonary fibrosis
Chronic diffuse
 Non-specific Interstitial
interstitial lung
 Pneumonia diseases
 Cryptogenic organizing
 Pneumonia
 Describe the microscopic RESP-S2-Path-5
features Pleural fluid for DR
Theme 2: Chronic Diffuse Interstitial/ Restrictive Lung Diseases

TEACHING
STRATEGY
Pathology
 Describe major categories RESP-S2-Path-6
 Explain the etiology, Chronic diffuse
 pathogenesis, gross, interstitial lung
 histological features diseases II-
6  of its important types like Pneumoconiosis
 Coal worker
 Pneumoconiosis
 Silicosis
 Asbestos-related diseases
 Explain the etiology, RESP-S2-Path-7
 pathogenesis, gross, Chronic diffuse
 histological features of interstitial lung
7
 Sarcoidosis diseases III:
 Hypersensitivity Pneumonitis Granulomatous
 Pulmonary Eosinophilia Diseases
 Smoking-related RESP-S2-Path-8
 Desquamative Interstitial Chronic diffuse
Pneumonia interstitial lung Interactive
 PAP (Pulmonary Alveolar diseases IV & smoking- SBQs & OSVE
8 Lecture
Proteinosis) related
 Respiratory bronchiolitis-
associated ILD

 Pathogenesis & histological Pulmonary
features of - Pulmonary Thromboembolism,
9
Thromboembolism, HTN HTN & important
 Goodpasture syndrome Hemorrhagic
Syndromes
 Pathogenesis and Clinical Pleural diseases
 features of
 Pleural effusion
10
 Pneumothorax
 Explain the etiology,
 Pathogenesis and
Microscopic
33
 features of
 Benign Tumors
Solitary fibrous tumor
 Malignant Tumors
 Mesothelioma
 Describe histopathological RESP-S2-Path-11
11 features Inflammatory diseases Practical OSPE & OSVE
of lung
Theme 3: Vascular, Infectious & Pleural Diseases

TEACHING
STRATEGY
Pathology
 Explain the pathogenesis of
granuloma formation
 Describe the five different clinical
patterns of tuberculosis RESP-S2-Path-12
12
 Define primary and secondary Tuberculosis
tuberculosis
 Describe lab diagnosis and
complications
 Pathogenesis and Clinical Interactive
SBQs & OSVE
 features of Lecture
 Pleural effusion
 Pneumothorax RESP-S2-Path-13
 Explain the etiology, Pleural diseases
13
 Pathogenesis and Microscopic
 features of
 Benign Tumors
Solitary fibrous tumor
 Mesothelioma
Microbiology
 Classify the medically important
RESP-S2-Micb-1
mycobacteria.
Mycobacterium
14  Describe the important tuberculosis &
properties, virulence factors
laprae
pathogenesis, clinical findings (Microbiology)
and lab diagnosis
Interactive
 Classify the gram-negative rods Lecture
SBQs & OSVE
related to the Respiratory tract. RESP-S2-Micb-2
 Describe the important Hemophilus
15 properties, pathogenesis, clinical influenzae &
findings and lab diagnosis of Bordetella pertussis
Hemophilus influenzae & (Microbiology)
Bordetella pertussis
Describe the clinical & microscopic RESP-S2-Path-14
16 features. Obstructive Practical OSPE & OSVE
diseases of lung
34
Theme 4: Lung Tumors
TEACHING
STRATEGY
Pathology
 Explain histological features of -
Squamous dysplasia &
Carcinoma in situ
 Atypical adenomatous
RESP-S2-Path-15
17 hyperplasia
Tumors of Lung-I
 Adenocarcinoma in situ
 Diffuse idiopathic pulmonary
neuroendocrine cell hyperplasia Interactive
SBQs & OSVE
(DIPNECH) Lecture
 pathogenesis, gross,
 histological features of RESP-S2-Path-16
18
 Squamous cell carcinoma Tumors of Lung-II
 Adenocarcinoma
 Neuroendocine carcinomas
 Morphological features & RESP-S2-Path-17
immunohistochemistry Tumors of lung
Pharmacology
 Classify the drugs used in
Asthma and COPD.
 Describe the mechanism
of action, side effects of beta-2 RESP-S2-Pharm-1
20 receptor Agonists, Drugs used in
Phosphodiesterase inhibitors Asthma and COPD
Leukotrienes Pathway Inhibitors Interactive
SBQs & OSVE
and Discuss the role of Lecture
corticosteroids in asthma.
 Classify the drugs used as Anti-
tussive. RESP-S2-Pharm-2
21  Describe the mechanism Drugs used as Anti-
of action, side effects of Anti- tussive
tussive drugs
35
Module: Foundation Module
Subject in Module Proportion of

subjects in Weightage Test Instrument/tool/method Explanation
module
Level 1 & 2 Level 1 Level 3
&2 Theory
Pathology 17 58 58 MCQs (SBQs)= 100 %;
Practical
Microbiology 02 07 07 OSVE=80%
Pharmacology 02 07 07 OSPE/OSCE= 20%

Clinical Lecture Miller’s Pyramid:
Cognition:
know (Level-2)
Skills & Attitude:
(Level-4)
29 100% 100 80% 20%
36
5 CARDIOVASCULAR MODULE-II
Introduction
Cardiovascular diseases are commonest causes of morbidity and mortality all over the world, such as
hypertension, ischemic heart disease, cardiac failure, and valvular disorders. Hence a medical graduate is
expected to manage these problems in the community at large. This module is designed to learn pathology
and pharmacology related to the cardiovascular system applying the background knowledge of anatomy,
physiology, and biochemistry. An emphasis is put on clinical correlation and problem-solving so that the
student will be able to build on the knowledge of clinical presentation, diagnostic investigations, and
management of cardiovascular disorders.
Apart from that, the parallel-running yet related courses in Forensic Medicine and Toxicology, Community
Medicine, and Behavioral Sciences are also part of this exciting new module.
Rationale
The orientation of various medical subjects is the fundamental requirement of every medical student.
Therefore, this module is designed to provide the integration of core concepts that underlie the foundation of
basic sciences and their correlation and application in the clinical context. Students also learn clinical skills
such as how to communicate effectively with patients and their relatives with compassion and understanding
of their issues/problems and how to resolve them in coming years. Working in groups will enhance students’
team working skills and capacity and management skills. Along with Lectures, practical’s and demonstrations;
through supplemented case-based learning they develop problem-solving skills to apply their basic medical
knowledge and skills to practical situations.
Duration:
04 weeks
Learning Outcomes
Knowledge:
At the end of this module, the students will be able to:
 Enlist pathologies involving cardiovascular system.

 Describe the management of the cardiovascular diseases.
 Perform the cardiovascular system examination.
 Take the history of the patients and co-relate the cardiovascular sign & symptoms to reach the
differential diagnosis
 To counsel the people in community regarding the risk factors of the cardiac diseases.
Clinical/ Practical skills

Placing electrodes and obtaining an electrocardiogram and interpretation of the basic ECG findings.
Perform clinical examination of the cardiovascular system.
37
Attitude:
Follow the basic laboratory protocols.
Participate in class and practical work professionally.
Communicate effectively in a team with pears, staff and teachers.
Demonstrate professionalism and ethical values in dealing with patients, peers, staff and
teachers.
Demonstrate the ability to reflect on the performance.
Themes
Theme 1: Hypertension
Theme 2: Atherosclerosis
Theme 3: Myocardial diseases
Theme 4: Diseases of vessels
Theme 5: Pericardial and endocardial diseases, and cardiac tumors

STRATEGIES
Theme 1: Hypertension
TEACHING
STRATEGY
Pathology
 Define hypertension and classify its
causes.
CVS-S2-Path-1
 Discuss the pathogenesis of
1 Hypertensive
Hypertension
Vascular Disease
 Vascular Pathology in
Hypertension.
 Define Hypertensive heart disease.
 Differentiate between systemic Interactive
SBQs & OSVE
(Left-Sided) HHD and Pulmonary Lecture
(Right-Sided) HHD (Cor
CVS-S2-Path-2
Pulmonale).
2 Hypertensive heart
 Describe the diagnostic features disease (HHD)
and morphology of Systemic and
Pulmonary HHD.
 Describe various disorders
predisposing to HHD.
Pharmacology
 Classify the antihypertensive
agents based on mechanism of
action. CVS-S2-Pharm-1
Interactive
3  Describe the hemodynamic Drugs used to
Lecture
SBQs & OSVE
Responses, adverse effects, and treat Hypertension
drug interactions of
antihypertensive agents.
Identify the following in a given CVS-S2-Pharm-2
4 prescription: Drug-Drug Practical OSPE & OSVE
interactions Flaws
38
Theme 2: Atherosclerosis
TEACHING
STRATEGY
Pathology
 Describe the pathogenesis of
Atherosclerosis.
 Discuss the morphological CVS-S2-Path-3
5
features of Atherosclerosis. Atherosclerosis
 Discuss the complications of
Atherosclerosis.
 Define Ischemic Heart Disease
with its types. Interactive
SBQs & OSVE
 Define Angina Pectoris with its Lecture
pathogenesis, patterns,
CVS-S2-Path-4
morphological changes, clinical
6 Ischemic Heart
features, and complications.
Disease
 Define Myocardial Infarction with
its pathogenesis, patterns,
morphological changes, clinical
features, and complications
 Interpret the following on a given CVS-S2-Path-5
biochemical report: Lipid Profile
7 Cardiac Enzymes Practical OSPE & OSVE
Pericardial
Effusion
Pharmacology
 Classify the Hypolipidemic drugs
according to their mode of action. CVS-S2-Pharm-3
8  Describe the clinical uses, drug Drugs to treat
interactions, and adverse effects Hyperlipidemia
of hypolipidemic drugs. Interactive
SBQs & OSVE
Lecture
 Classify anti-anginal drugs based CVS-S2-Pharm-4
on the mechanism of action. Drugs used to
9
 Describe adverse effects and drug treat Ischemic
interaction of antianginal drugs. Heart Disease
Write down a prescription based on a CVS-S2-Pharm-5
10 given scenario. Dyslipidemia Practical OSPE & OSVE
Hypertension
Theme 3: Myocardial Diseases

TEACHING
STRATEGY
Pathology
 Define Cardiomyopathy and
classify it.
 Des cribe the pathogenesis, CVS-S2-Path-6
11
patterns, morphological changes, Cardiomyopathies
clinical features, and complications Interactive
SBQs & OSVE
of various cardiomyopathies. Lecture
 Define valvular stenosis and
CVS-S2-Path-7
insufficiency.
12 Valvular Heart
 Describe the causes of the major Disease and
valvular lesions.
39
 Describe the natural history of Rheumatic Heart
Rheumatic Fever. Disease
 Describe Calcific Valvular
Degeneration and characterize it.
 Discuss the morphology and
clinical features.
Pharmacology
 List the major classes of anti-
arrhythmic drugs based on their CVS-S2-Pharm-6
mechanism of action. Drugs used to
13
 Describe the clinical use, drug treat Cardiac
interactions, and adverse effects of Arrhythmias
anti-arrhythmic drugs.
 Classify the major classes of drugs
used to treat congestive cardiac
Interactive
failure based on their mechanism SBQs & OSVE
Lecture
of action.
CVS-S2-Pharm-7
 Describe the pharmacokinetics,
Drugs used to
14 mechanism of action, indications, treat Congestive
and adverse effects of drugs used Cardiac Failure
in acute and chronic heart failure.
 Describe the clinical use, drug
interactions, and adverse effects of
drugs used in CCF.
Clinical Lecture
 Describe the sign and symptoms of CVS-S2-Cardio-1
RF and RHD Rheumatic Fever
15  Describe the drugs used to treat and Rheumatic
RHD and there adverse effects Heart Disease
(RHD)
 Describe the sign and symptoms of Interactive
SBQs & OSVE
pericarditis, myocarditis, and Lecture
infective endocarditis. CVS-S2-Cardio-2
16  Describe the treatment of Cardiac
inflammation
pericarditis, myocarditis, and
infective endocarditis.
Theme 4: Diseases of Vessels

TEACHING
STRATEGY
Pathology
 Define vasculitis and classify
primary forms.
 Describe causes and mechanisms.
 Describe the typically involved
vascular sites. CVS-S2-Path-8
17
 Describe the following and Vasculitis
Interactive
characterize them: SBQs & OSVE
Lecture
 Giant Cell (Temporal) Arteritis
 Thromboangiitis Obliterans
(Buerger Disease)
 Describe varicose veins and their CVS-S2-Path-9
18 clinical features. Diseases of Veins
and Lymphatics
40
 Differentiate between
Thrombophlebitis and
Phlebothrombosis based on
pathogenesis and clinical features.
 Describe Lymphangitis and
Lymphedema.
Theme 5: Pericardial and Endocardial Diseases, and Cardiac Tumors

TEACHING
STRATEGY
Pathology
 Classify vascular tumors and
tumor-like conditions.
 Describe the pathogenesis,
morphology, and clinical
characteristics of the following: CVS-S2-Path-10 Interactive
20 SBQs & OSVE
 Hemangiomas Vascular Tumors Lecture
 Lymphangiomas
 Intermediate-Grade (Borderline)
Tumors
 Describe the pathogenesis, CVS-S2-Path-11
morphology, and Infective
clinical
characteristics of IE, Pericarditis, Endocarditis (IE), Interactive
21 SBQs & OSVE
and cardiac tumors. Pericarditis, and Lecture
Tumors of the
Heart
 Interpret the gross and microscopic CVS-S2-Path-12
22 features of the following on a given Hemangiomas Practical OSPE & OSVE
histopathology report: Cardiac Myxoma
41
Module: CVS 2 Module
Proportion of
module
Level 1 & Level 1 & Level 3
2 2 Theory
Practical
Microbiology OSVE=80%

Clinical Lecture 02 08 08 Miller’s Pyramid:
Cognition:
know (Level-2)
Skills & Attitude:
(Level-4)
25 100% 100 80% 20%
42
6 GASTROINTESTINAL TRACT & LIVER MODULE II
Introduction
Welcome to the GIT and Liver module. This exciting module will serve as building block and is very essential
This module covers the topics which are Inflammatory and Neoplastic Diseases of Salivary Gland, Non-
neoplastic and Tumor of Esophagus, Gastritis and Peptic Ulcer, Malignancies of Stomach, Diarrheal
Diseases, Malabsorption Syndromes and Inflammatory Bowel Diseases, Benign and Malignant Lesions of
Small and Large Intestine. Pathological conditions of Liver like Jaundice and cholestasis, Autoimmune liver
diseases & Cholangiopathies, Metabolic Liver Diseases-1, Drug and Toxin Induced Liver Injury & Fatty Liver
Disease, Cirrhosis of liver, Tumors of Liver, Inflammatory Diseases and Tumors of Gall Bladder. All these
diseases are very common in clinical practice and will be helpful in understanding the GIT and Liver
pathology. Real life scenarios have been added in the module which will be discussed in small groups to help
students to develop them clinical approach to understand and solve the clinical problem by correlating their
basic knowledge of anatomy, physiology, biochemistry and pathology with findings of a clinical case.
Rationale
Diseases of the GIT are common all over our country. It is essential to make early diagnosis and treat the
disease in order to reduce morbidity and mortality.
This module provides an integrative understanding and detailed and clinically relevant information of
pathology related to the digestive and biliary system.
Learning Outcomes
At the end of the module, the students will be able to relate understanding of the pathological processes
related to the gastrointestinal tract & Liver.
Duration:
04 weeks
Themes
Theme 1: Disease of oral cavity and esophagus
Theme-2: Disease of stomach
Theme-3: Diarrheal diseases and malabsorption syndromes
Theme-4: Intestinal disorders
Theme-5: Jaundice & cholestasis
Theme-6: Metabolic & drug/toxin related liver diseases
Theme-7: Cirrhosis
Theme 8: Tumors of liver and gall bladder
43
STRATEGIES
Theme 1: Disease of Oral Cavity and Esophagus
TEACHING
STRATEGY
Pathology
 Define leukoplakia and
erythroplakia.
 Describe ulcer of oral cavity and
define dental caries, fungal GIL-S2-Path-1
infection and inflammatory Ulcer/ inflammatory
1
condition of oral cavity. lesion and cancer of
 Name the malignant tumors of oral cavity
oral mucosa & describe their
etiopathology, morphology and
clinical features.
 Mention cause of sialadenitis,
clinical features and morphology. GIL-S2-Path-2
 Name benign and malignant Disease of salivary
2
tumors of salivary gland. gland inflammation Interactive
SBQs & OSVE
 Describe etiopathology, and tumor Lecture
morphology and clinical features.
 Define achalasia, mention its GIL-S2-Path-3
causes and morphology. Motor disorders.
 Describe causes of Esophageal varices,
3 Hematemesis. inflammatory
 Describe pathogenesis, clinical condition and
features of GERD gastroesophageal
 Mention causes of dysphagia. reflux
 Name benign and malignant
tumors of esophagus. GIL-S2-Path-4
4  Describe etiopathology, clinical Tumors of
features and morphology of esophagus
carcinoma esophagus.
GIL-S2-Path-5
Gross and
Demonstrate Gross and microscopic features
microscopic features of oral cavity of oral cavity
carcinoma, salivary gland tumor and carcinoma, salivary
carcinoma esophagus. gland tumor and
carcinoma
esophagus.
Pharmacology
Drugs used for dyspepsia (Antacids Interactive
6 GIL-S2-Pharm-1 SBQs & OSVE
and prokinetic drugs) Lecture
Clinical Lectures
Discuss Gastroesophageal reflux, GIL-S2-Med-1
esophagitis, Barrett’s esophagus Gastroesophageal
Interactive
7 and hiatal hernia reflux, esophagitis, SBQs & OSVE
Lecture
Barrett’s esophagus
and hiatal hernia
Discuss Surgical causes, GIL-S2-Surg-1
Interactive
8 presentation and management of Surgical causes, SBQs & OSVE
Lecture
presentation and
44
hematemesis, dysphagia and management of
carcinoma esophagus hematemesis,
dysphagia and
carcinoma
esophagus
Theme 2: Disease of Stomach

TEACHING
STRATEGY
Pathology
 Mention causes, pathogenesis
of gastritis (Acute and chronic)
 Describe causes, etiopathology,
complication and morphology of GIL-S2-Path-6
9 peptic ulcer disease. Gastritis and peptic
 Mention role of H. Pylori in peptic ulcer disease
Interactive
ulcer disease, describe various SBQs & OSVE
Lecture
methods of diagnosis of H. Pylori
infection.
Name benign and malignant tumors
of stomach, describe etiopathology, GIL-S2-Path-7
10
clinical features and morphology of Tumor of stomach
carcinoma stomach.
GIL-S2-Path-8
Demonstrate Gross and Gross and
11 microscopic features of peptic ulcer microscopic features Practical OSPE & OSVE
and carcinoma stomach of peptic ulcer and
carcinoma stomach
Pharmacology
Describe drugs used for Acid peptic GIL-S2-Pharm-2
disorders including H. Pylori Drugs used for Acid
infection proton pump inhibitors peptic disorders Interactive
12 SBQs & OSVE
including H. Pylori Lecture
infection proton
pump inhibitors
Clinical Lectures
GIL-S2-Med-2
Diagnosis and
Discuss diagnosis and
management of
management of gastritis/Acid peptic
gastritis/Acid peptic
13 disease and endoscopic
disease and
management of bleeding peptic
endoscopic
ulcer
management of Interactive
SBQs & OSVE
bleeding peptic ulcer Lecture
Surgical management in Acid peptic GIL-S2-Surg-2
disease and carcinoma of stomach. Surgical
management in Acid
14
peptic disease &
carcinoma of
stomach.
45
Theme 3: Diarrheal Diseases and Malabsorption Syndromes
TEACHING
STRATEGY
Pathology
 Name various cases of
enterocolitis.
 Mention various causes of GIL-S2-Path-9
diarrhea and dysentery Enterocolitis and
15
(Microbiology). ischemic colitis,
 Describe clinical features. Hemorrhoids
 Mention etiopathogenesis and
clinical features.
 Define malabsorption and name
GIL-S2-Path-10 Interactive
various causes. SBQs & OSVE
Malabsorption Lecture
16  Describe clinical features,
syndrome (Coeliac
etiopathology, morphology and disease)
diagnosis of coelic disease.
 Name inflammatory bowel
disease.
GIL-S2-Path-11
17  Describe etiopathology, clinical Inflammatory bowel
features and morphological diseases
features of Crohn's disease and
ulcerative colitis.
GIL-S2-Path-12
various microbial
 Describe various microbial
agents causing
agents causing diarrhea and
18 diarrhea and Practical SBQs & OSVE
dysentery and mention their lab
dysentery and
diagnosis.
mention their lab
diagnosis.
Pharmacology
Describe Emetics and GIL-S2-Pharm-3 Interactive
19 Antiemetic’s Emetics and
Lecture
SBQs & OSVE
Antiemetic’s
Clinical lecture
GIL-S2-Med-3
Causes and clinical
presentation and
Explain Causes and clinical
management of
presentation and management of
20 malabsorption
malabsorption syndrome / Coeliac
syndrome / Coeliac
disease. Irritable bowel syndrome.
disease.
Irritable bowel
syndrome.
Discuss Clinical presentation GIL-S2-Surg-3 Interactive
and surgical management of Clinical Lecture
SBQs & OSVE
inflammatory bowel disease. presentation and
21 surgical
management of
inflammatory bowel
disease.
Discuss causes and clinical GIL-S2-Paeds-1
presentation and management Causes and clinical
22 of acute diarrhea. presentation and
management of
acute diarrhea.
46
Theme 4: Intestinal Disorders
TEACHING
STRATEGY
Pathology
 Mention various causes of
intestinal obstruction
 Define volvulus, intussusception,
GIL-S2-Path-13
23 hernias and adhesions.
Intestinal obstruction
 Discuss etiopathogenesis,
clinical features and morphology
of Hirschsprung disease.
 Define acute appendicitis.
 Describe causes, clinical
features and morphology of
GIL-S2-Path-14
acute appendicitis.
Inflammatory
24  Mention clinical features and condition of
morphology of Meckel’s abdomen
diverticulitis.
 Define diverticulosis, describe Interactive
SBQs & OSVE
etiopathology and morphology. Lecture
 Name benign polypoidal lesion of
intestine.
 Describe etiopathology, clinical
GIL-S2-Path-15
features and morphology of
Benign tumors of
25 benign polyp.
small intestine and
 Define familial adenomatous
large intestine-1
polyposis syndrome.
 Describe etiopathology and
morphology of FAP syndrome.
 Name malignant tumor of large
GIL-S2-Path-16
intestine.
Malignant tumors of
26  Describe etiopathology, clinical small intestine and
features and morphological large intestine-2
features.
GIL-S2-Path-17
Describe gross and microscopic
Benign and
27 features of benign and malignant Practical OSPE & OSVE
malignant tumors of
tumors of intestine.
intestine.
Pharmacology
 Describe drugs used in GIL-S2-Pharm-4
constipation. Drugs used in
 Explain management of diarrhea constipation.
Interactive
28 and inflammatory bowel Management of SBQs & OSVE
Lecture
syndrome. diarrhea and
inflammatory bowel
syndrome.
Clinical Lecture
Discuss causes and management GIL-S2-Surg-4
of intestinal obstruction Causes and
Interactive
29 management of SBQs & OSVE
Lecture
intestinal
obstruction.
47
Theme 5: Jaundice & Cholestasis
TEACHING
STRATEGY
Pathology
Describe
 Bile Formation and Secretion
 Pathophysiology of
Hyperbilirubinemia
 Explain etiology & clinical
diagnosis of
 Pre-Hepatic Jaundice GIL-S2-Path-18
30  Hepatic Jaundice Jaundice and
 Post-Hepatic Jaundice cholestasis
 Hereditary Hyperbilirubinemia
 Gilbert's syndrome
Crigler–Najjar syndrome type I &
II Interactive
SBQs & OSVE
 Dubin-Johnson syndrome (DJS) Lecture
 Rotors syndrome (DJS)
Explain etiology, pathogenesis &
clinical features & Diagnostic criteria
of
 Type I Autoimmune liver
GIL-S2-Path-19
diseases
Autoimmune liver
31  Type II Autoimmune liver
diseases &
diseases
Cholangiopathies
 Primary Biliary Cholangitis
(PBC)
 Primary Sclerosing Cholangitis
(PSC)
Theme 6: Metabolic & Drug/Toxin Related Liver Diseases
TEACHING
STRATEGY
Pathology
Explain etiology, pathogenesis
& clinical features &Diagnostic
criteria of GIL-S2-Path-20
32 Metabolic Liver
 Hemochromatosis
Diseases-1
 Wilson Disease
Interactive
 α1-Antitrypsin Deficiency SBQs & OSVE
Lecture
Explain etiology, pathogenesis GIL-S2-Path-21
& clinical features &Diagnostic Drug- and Toxin-
33 criteria of Induced Liver
 Alcoholic Liver Disease Injury & Fatty Liver
 Nonalcoholic Fatty liver Disease
48
Theme 7: Cirrhosis
TEACHING
STRATEGY
Pathology
 Describe etiology,
GIL-S2-Path-22 Interactive
34 pathogenesis, symptoms SBQs & OSVE
Cirrhosis of liver Lecture
and complications
35  Demonstrate gross and GIL-S2-Path-23
microscopic features Cirrhosis of liver
Pharmacology
Describe drugs used in GIL-S2-Pharm-5 Interactive
36 SBQs & OSVE
Hepatitis Drugs used in Hepatitis Lecture
Clinical Lecture
Discuss Clinical presentation GIL-S2-Med-4
and outline management of Clinical presentation
37 Hepatitis B&C and outline
management of
Hepatitis B&C
Discuss management of acute GIL-S2-Med-5
Interactive
hepatitis and fulminant hepatic Management of acute SBQs & OSVE
38 Lecture
failure hepatitis and fulminant
hepatic failure
Discuss clinical presentation GIL-S2-Surg-5
and indication of surgery in Clinical presentation
39
liver cirrhosis. and indication of
surgery in liver cirrhosis.
Theme 8: Tumors of Liver and Gall Bladder
TEACHING
STRATEGY
Pathology
Describe Etiology,
pathogenesis, gross &
histologic Features of
 Focal Nodular Hyperplasia,
cavernous Hemangioma GIL-S2-Path-24
40
Tumors of liver
 Hepatocellular Adenoma
 Hepatoblastoma
 Hepatocellular Carcinoma Interactive
SBQs & OSVE
 Malignant Biliary Tumors Lecture
State congenital anomalies
etiology, pathogenesis, gross &
histologic Features of GIL-S2-Path-25
41  Cholelithiasis (Gall stones) Diseases & Tumors of
 Acute & Chronic gall bladder
Cholecystitis
 Gall bladder Carcinoma
 Demonstrate gross and
microscopic feature of GIL-S2-Path-26
42 hepatocellular carcinoma Ca liver and Gall Practical SBQs & OSVE
and carcinoma gall bladder Bladder
49
Clinical Lecture
Describe Cirrhosis, partial GIL-S2-Med-6
hypertension, variceal Cirrhosis, partial
bleeding, medical and hypertension, variceal
43
endoscopic management. bleeding, medical and
endoscopic
management.
Describe Ascites, Hepatic GIL-S2-Med-7 Interactive
SBQs & OSVE
encephalopathy and hepato Ascites, Hepatic Lecture
44
renal syndrome encephalopathy and
hepato renal syndrome
Describe Clinical presentation GIL-S2-Surg-6
and management of Clinical presentation
45
cholelithiasis and management of
cholelithiasis
50
Module: GIL 2 Module
Proportion of
module
Level 1 Level 1 Level Theory
&2 &2 3 MCQs (SBQs)= 100 %;
Pathology 26 45 45 Practical
OSVE=80%
Microbiology OSPE/OSCE= 20%
Pharmacology 05 09 09
Competency level &
Community 14 24 24 Learning Domain at
medicine Miller’s Pyramid:
Clinical Lecture 13 22 22 Cognition:
know (Level-2)
Skills & Attitude:
(Level-4)
58 100% 100 80% 20%
51
7 ENDOCRINOLOGY MODULE II
Introduction
The Endocrine system is made up of ductless glands, which secrete chemical substances (hormones) directly
into blood, relays information and maintains a constant internal environment of the body called homeostasis.
The endocrine glands where hormones are produced, stored, and released. Once released into the
bloodstream, they travel to their target organ or tissue, which has receptors that recognize and react to the
hormone. Hormones of the endocrine system coordinate and control growth, metabolism, temperature
regulation, the stress response, reproduction, and many other functions.
This module will help the students to develop knowledge and understanding the basic concepts of endocrine
hormone their disorders relates to primary pathogenesis, and how this knowledge help in diagnosis and
treatment.
This endocrine system module will facilitate to recognize the clinical presentations of common
endocrinological and metabolic disorders and relate clinical manifestations to basic sciences.
Rationale
Endocrine disorders like Diabetes Mellitus and Thyroid related diseases are very common in all parts of
Pakistan. This module provides the basis on which 3rd year MBBS students will learn not only knowledge
application to know the pathology but will be able to link abnormalities with treatment options in the 2nd spiral
of the curriculum.
Common endocrinological disorders like Diabetes mellitus, thyrotoxicosis, hypothyroidism, Cushing
syndrome, pituitary disorders are necessary to be understood for comprehensive management. These
diseases are commonly encountered in medical practice. In this module with the integration of the basic
knowledge obtained in the first spiral, a sound clinical base is developed by learning their pharmacotherapy
in detail.
Duration:
02 weeks
Learning Outcomes
 Describe the clinical uses and adverse effects of growth hormone and adrenocorticotropic (ACTH)
hormones.
 Explain the therapeutic effects of thyroxine in the treatment of hypothyroidism.
 Explain the mechanism of action, therapeutic and adverse effects of anti-thyroid drugs.
 Explain the therapeutic and preventive role of iodine in thyroid disorders.
 Classify diabetes mellitus on the basis of WHO criteria.
 Describe the pathogenesis, clinical features, pathological changes, complications and prevention of
diabetes mellitus.
 Describe the pharmacokinetics, mechanism of action and adverse effects of insulin and oral
hypoglycemic agents.
 Classify mineralocorticoids & glucocorticoids on the basis of duration of action, anti-inflammatory
and salt retaining properties.
 Describe the clinical uses and adverse effects of mineralocorticoids and glucocorticoids.
 To describe and discuss the roles of hormone receptors in hormone action including their location,
type and signaling pathways.
 To apply endocrinological principles to determine the pathophysiological basis and consequences
of specific endocrine disorders.
 Discuss the epidemiology and consequences of iodine deficiency and the salient features of iodine
control program in Pakistan
52
 Describe the epidemiology of diabetes mellitus in terms of global perspectives in Pakistan
 Describe the levels of prevention of diabetes mellitus and its control.
Themes
Theme 1: Non-neoplastic & neoplastic diseases of Pituitary Gland
Theme 2: Non-neoplastic & neoplastic diseases of Thyroid & Parathyroid
Theme 3: Non-neoplastic & neoplastic diseases of Pancreas
Theme 4: Non-neoplastic & neoplastic diseases of Adrenal Gland
Theme 5: Multiple Endocrine Neoplasia Syndromes

STRATEGIES
Theme 1: Non-Neoplastic & Neoplastic Diseases of Pituitary Gland
TEACHING
STRATEGY
Pathology
 Describe clinical
manifestations of Anterior
Pituitary gland disorders &
Syndromes
 Describe the pathophysiology
and Histologic features of End-S2-Path-1
i. Lactotroph Adenoma Disorders and Interactive
1 SBQs & OSVE
ii. Somatotroph Adenoma neoplasms of Pituitary Lecture
iii. Corticotroph Adenoma gland.
iv. Other Anterior Pituitary
Tumors
 Explain histologic features of
Hypothalamic Suprasellar
Tumors
Pharmacology
Discuss the pharmacology of End-S2 Pharm-1
Interactive
2 anterior pituitary growth hormone Anterior pituitary SBQs & OSVE
Lecture
(Somatotropin) hormones
Clinical Lecture
Describe clinical manifestations of End-S2 Med-1
the anterior & posterior pituitary Hypopituitarism/ Pan
gland. hypopituitarism,
3
GHD, Sheehan
Syndrome.
Diabetes Insipidus
 Describe the clinical features
of pituitary tumors + End-S2 Med-2
Hypothalamic suprasellar Pituitary tumors + Interactive
4 SBQs & OSVE
tumors. Hypothalamic Lecture
 Clinical features of Hyper suprasellar tumors
function tumors + Mass effects
 Identify the indications for
trans sphenoidal
Hypophysectomy Endo-S2-Surgery-1
5
 Describe the technique in Hypophysectomy
regards to trans sphenoidal
Hypophysectomy
53
 Outline the appropriate
evaluation of the potential
complications of trans
sphenoidal Hypophysectomy
 Review some interprofessional
team strategies for improving
care, coordination and
communication to advance
transsphenoidal
Hypophysectomy and improve
outcomes
Theme 2: Non-Neoplastic & Neoplastic Diseases of Thyroid &

Parathyroid
TEACHING
STRATEGY
Pathology
 Describe the pathophysiology of
i. Hyperparathyroidism
ii. Primary End-S2-Path-2
Hyperparathyroidism Disorder of
6
iii. Secondary Parathyroid gland
Hyperparathyroidism
iv. Hypoparathyroidism
v. Pseudohypoparathyroidism
 Histology thyroid hormones T3
End-S2-Path-3
and T4 synthesis and functions.
Diseases of Thyroid
 Pathophysiology, clinical
gland
7 features and laboratory
Introduction
diagnosis of simple and
Simple goiter and
multinodular goiter.
Multinodular goiter
 Toxic multinodular goiter
 Hyperthyroidism and
thyrotoxicosis. End-S2-Path-4
 Primary and secondary Hyperthyroidism.
hyperthyroidism. Graves’ disease Interactive
8
 Pathophysiology causes, clinical Thyroid storm Lecture
SBQs & OSVE
features and laboratory Apathetic
diagnosis of Graves’ disease hyperthyroidism
 Thyroid function and its
End-S2-Path-5
Hypothyroidism its causes clinical Hypothyroidism
9
features and laboratory diagnosis Cretinism
Myxedema
Discuss Clinical and morphological
features of: End-S2-Path-6
i. Hashimoto Thyroiditis Inflammatory
10
ii. Subacute Lymphocytic diseases of Thyroid
Thyroiditis gland
iii. Granulomatous Thyroiditis
Causes, pathogenesis,
morphological features and End-S2 Path-7
11
laboratory diagnosis of thyroid Thyroid Neoplasms-I
adenoma and papillary carcinoma
Causes, pathogenesis, End-S2-Path-8
12
morphological features and Thyroid
54
laboratory diagnosis of follicular Neoplasms-II
carcinoma, medullary carcinoma
and anaplastic carcinoma.
Laboratory interpretation of End-S2-Path-9
13 parathyroid gland diseases Parathyroid gland
Lab interpretation
Thyroid function test and its End-S2-Path-10
14 interpretation according to disease Thyroid function
tests
Neoplastic lesions of thyroid gland End-S2-Path-11
Benign and
15
malignant tumors of
thyroid gland
Pharmacology
 Classify the drugs used in
Thyroid disorders End-S2-Pharm-2
16  Pharmacological effects of anti- Introduction to Basic
thyroid drugs pharmacology of Interactive
SBQs & OSVE
 Discuss the drugs used for Thyroid drugs Lecture
hypothyroidism
Drugs used in parathyroid disorders End-S2-Pharm-3
17
(Tetany) Parathyroid agents
Clinical Lecture
Describe the clinical features & End-S2-Med-3
management of & Primary+
18
Hyperparathyroidism Secondary+ tertiary.
Hyperparathyroidism
Describe the clinical features & End-S2-Med-4
management of Primary+
hypoparathyroidism Secondary+ tertiary.
19
Hypoparathyroidism
+ Pseudo
hypoparathyroidism
Discuss Clinical features of End-S2-Med-5
inflammatory thyroid disorders Thyroiditis.
Hypothyroidism
20
(Hashimoto thyroid
disease, Myxedema
and cretinism) Interactive
Discuss Clinical features of End-S2-Med-6 SBQs & OSVE
Lecture
21 inflammatory thyroid disorders Hyperthyroidism
(Graves’ disease)
 Discuss Toxic adenoma. End-S2-Med-7
 Multinodular Goiter Goiter + Adenoma +
22
 Simple Nontoxic goiter Thyroid
 Types of thyroid carcinomas. Malignancies.
 Identify the indications of Para
thyroidectomy
 Describe the technique of Para
thyroidectomy.
End-S2-Surg-2
23  Review the clinical significance
Para thyroidectomy.
of Para thyroidectomy.
 Summarize the potential
complications of Para
thyroidectomy
55
Theme 3: Non-Neoplastic & Neoplastic Diseases of Pancreas
TEACHING
STRATEGY
Pathology
Glucose homeostasis, metabolic
action of insulin and mechanism of
End-S2-Path-12
insulin release. Classification of
Disorder of
24 diabetes mellitus. Types of
Endocrine Pancreas
incretins. Impaired glucose
Diabetes Mellitus-1
tolerance test. Laboratory diagnosis
of diabetes mellitus
Pathogenesis of type-I and type-II End-S2-Path-13
diabetes mellitus, clinical Disorder of
25
presentation and complications of Endocrine Pancreas
diabetes mellitus. Diabetes mellitus-II Interactive
SBQs & OSVE
 Discuss clinical presentation, Lecture
pathogenesis and histologic
features of Common Pancreatic
Endocrine Neoplasms End-S2-Path-14
26
Hyperinsulinism (Insulinoma) Pancreatic tumors
Zollinger-Ellison Syndrome
 (Gastrinoma)
Pancreatic carcinoid tumors
Diabetes mellitus its type and End-S2-Path-15
27 laboratory interpretation Diabetes mellitus
Lab interpretation
Pharmacology
Describe the pharmacology of
End-S2-Pharm-4
28 insulin and benefits of glycemic
Pancreas (Insulin)
control in diabetes mellitus type-I Interactive
SBQs & OSVE
Describe the drugs used in type II End-S2-Pharm-5 Lecture
29 diabetes mellitus. Non-Insulin
antidiabetic agents
Clinical Lecture
 Describe Diabetes (Definition +
End-S2-Med-8
30 WHO Classification).
Diabetes Mellitus-I Interactive
 Management of diabetes. SBQs & OSVE
Lecture
 Discuss Acute & chronic End-S2-Med-9
31
complications of diabetes. Diabetes Mellitus-II
Theme 4: Non-Neoplastic & Neoplastic Diseases of Adrenal Gland

Theme 5: Multiple Endocrine Neoplasia Syndromes
TEACHING
STRATEGY
Pathology
 Describe the hyper-secretory & End-S2-Path-16
hypo-secretory disorders of Non-neoplastic
adrenal cortex diseases of adrenal
 Adrenocortical Hyperfunction cortex
Interactive
32 Hypercortisolism (Cushing Neoplastic diseases SBQs & OSVE
Lecture
 Syndrome) of adrenal cortex &
Primary Hyperaldosteronism Medulla
Adrenogenital Syndromes MEN-I & MEN-II
 Adrenocortical Insufficiency
56
Primary Acute Adrenocortical
 Insufficiency
Primary Chronic Adrenocortical
 Insufficiency (Addison Disease)
 Discuss clinical presentation,
pathogenesis and histologic
features of
 Adrenocortical Neoplasms
Adrenocortical adenomas
Pheochromocytoma.
Pharmacology
Describe the pharmacokinetic End-S2-Pharma-6
33 pharmacodynamics clinical uses Corticosteroids
and toxicity of glucocorticoids (Glucocorticoids).
Discuss the pharmacology of End-S2-Pharm-7 Interactive
34 SBQs & OSVE
mineralo corticoids. Mineralo corticoids Lecture
Discuss the corticosteroid End-S2-Pharm-8
35 antagonists Corticosteroid
antagonists
Medicine
 Describe Diabetes (Definition +
End-S2-Med-8
36 WHO Classification).
Diabetes Mellitus-I
 Management of diabetes.
Discuss Acute & chronic End-S2-Med-9
37
complications of diabetes. Diabetes Mellitus-II
Describe the clinical manifestations
End-S2-Med-10
38 of Hyper functioning of the Adrenal
Cushing Syndrome
gland. (Cortex)
End-S2-Med-11
Describe the clinical manifestations
Adrenal
39 of hypo functioning of the Adrenal
insufficiencies Interactive
gland. (Cortex) SBQs & OSVE
(Addison disease) Lecture
Describe the clinical features of. End-S2-Med-12
Corticotrophin adenoma. Corticotrophin
40 adenoma. (Cushing
Syndrome of
pituitary origin)
Discuss the Clinical manifestation of End-S2-Med-13
41 Adrenal Medullary tumors + Pheochromocytoma
paragangliomas + paragangliomas
Discuss the genetic mutation in End-S2-Med-14
42
Endocrinology MEN-I, MEN-II, A&B
Surgery
 Identify the indications of
adrenalectomy
 Describe the management of End-S2-Surg-3 Interactive
43 SBQs & OSVE
adrenalectomy Adrenalectomy Lecture
 Outline the complications of
adrenalectomy
57
Module: Endocrine-2 Module
Proportion of
module
Level 1 & Level 1 Level 3
2 &2 Theory
Practical
Microbiology OSVE=80%

Clinical Lecture 14 32 32 Miller’s Pyramid:
Cognition:
know (Level-2)
Skills & Attitude:
(Level-4)
42 100% 100 80% 20%
58
8 RENAL/ EXCRETORY SYSTEM MODULE-II
Introduction
Welcome to the Renal & excretory module. This exciting module will serve as building block and is very
essential to your future work as doctors. This module is designed to make your learning both interesting and
productive by including several inter active activities.
This module covers the topics which are Pathogenesis of glomerular disease, Glomerular conditions
associated with system disorders and Isolated glomerular abnormalities, Renal vascular disease, Obstructive
uropathy (Urolithiasis, Hydronephrosis), Tumors of Renal and Lower Urinary System, Kidney function tests,
Urine Analysis and Urine C/S. All these topics are interactive and helpful in understanding the renal
pathology.
Rationale
Renal system and excretory system is Responsible for the body to get rid of waste and toxic substances. In
this module the renal and excretory system will be examined in detail with emphasis on Pathogenesis of
glomerular disease, Glomerular conditions associated with system disorders and Isolated glomerular
abnormalities, Renal vascular disease, Obstructive uropathy (Urolithiasis, Hydronephrosis), Tumors of Renal
and Lower Urinary System, Kidney function tests, Urine Analysis and Urine C/S.
This module will enable the students of third year to recognize the clinical presentations of common renal
diseases and relate clinical manifestations to basic sciences.
Duration:
03 weeks
Learning Outcomes
At the end of this module, the students will be able to understand common clinical problems like kidney
syndromes and to correlate with Pathogenesis of glomerular disease, Glomerular conditions associated with
systemic disorders and Isolated glomerular abnormalities, Renal vascular disease, like benign and malignant
nephrosclerosis, Obstructive uropathy (Urolithiasis, Hydronephrosis), Tumors of Renal and Lower Urinary
System, Kidney function tests, Urine Analysis and Urine C/S.
Themes
Theme 1: Glomerular conditions including glomerular syndromes, conditions associated with
systemic disorders and Isolated glomerular abnormalities.
Theme 2: Kidney/ Excretory Infections and Renal Vascular Disorders
Theme 3: Obstructive uropathy (Urolithiasis, Hydronephrosis)
Theme 4: Tumors of Renal/ excretory System
59
STRATEGIES
Theme 1: Glomerular Conditions Including Glomerular Syndromes,

Conditions Associated with Systemic Disorders and
Isolated Glomerular Abnormalities
TEACHING
STRATEGY
Pathology
 Classify glomerular disease.
 Define glomerular syndrome
1  Discuss pathogenesis of EXC-S2-Path-1
glomerular injury and Glomerular diseases
mediators of glomerular
injury.
 Describe various glomerular
syndromes
 Define nephritic syndrome
 Describe pathophysiology EXC-S2-Path-2
2 and clinical features of
Nephritic Syndrome
nephritic syndrome
nephritic and nephrotic
syndrome.
 Define and describe causes:
 Pathophysiology and clinical Interactive
features of nephrotic SBQs & OSVE
EXC-S2-Path-3 Lecture
3 syndrome.
Nephrotic Syndrome
nephritic and nephrotic
syndrome.
 Discuss the
pathophysiology,
morphology and clinical
features in glomerular
EXC-S2-Path-4
conditions associated with
Glomerular conditions
systemic disease e.g
associated with system
4 Diabetic nephropathy, Lupus
disorders and Isolated
nephritis, henoch schonlein
glomerular
purpura.
abnormalities
 Explain isolated glomerular
abnormalities including IGA
nephropathy, Hereditary
nephritis, Alport syndrome.
 Name kidney function test
 Mention clinical EXC-S2-Path-5
5 interpretation of serum urea, Practical OSPE & OSVE
Kidney function tests
creatinine, BUN and
creatinine clearance test.
60
Theme 2: Kidney/ Excretory Infections and Renal Vascular Disorders
TEACHING
STRATEGY
Pathology
 Describe causes and pathogenic
mechanism of tubulointerstitial
injury
 Etiology, pathogenesis and EXC-S2-Path-6
6 morphology of acute tubular Tubulo insterstitial
necrosis. Injury
 Describe etiopathogenesis and
morphology of tubulointerstitial
nephritis.
 Identify predisposing factors of
pyelonephritis
 Describe causes, pathogenic
mechanisms and morphology of EXC-S2-Path-7
7
acute pyelonephritis. Pyelonephritis
 Describe clinical course and
complications of acute
pyelonephritis. Interactive
SBQs & OSVE
 Define chronic pyelonephritis Lecture
EXC-S2-Path-8
8  Enumerate causes and
Chronic
morphological features of chronic
Pyelonephritis
pyelonephritis.
 Identify the causes of UTI. EXC-S2-Path-9
9  Describe predisposing factors and Urinary tract
clinical presentation. infections
 Classify renal vascular disease.
 Discuss etiology, pathogenesis,
morphology, clinical features of
benign and malignant
EXC-S2-Path-10
nephrosclerosis.
10 Renal Vascular
 Define renal artery stenosis disease
mention its causes, clinical
features. Describe thrombotic
microangiopathy and other
vascular disorders
EXC-S2-Path-11
Describe urine detail report and
11 Urine Analysis and Practical OSPE & OSVE
different methods of urine culture
Urine Culture
Theme 3: Obstructive Uropathy (Urolithiasis, Hydronephrosis)
TEACHING
STRATEGY
Pathology
 Name various types of renal
calculi. EXC-S2-Path-12
12
 Describe etiopathology causes Kidney stones
Interactive
and complication. SBQs & OSVE
Lecture
Identify causes, pathophysiology,
EXC-S2-Path-13
13 gross and microscopic features &
Hydronephrosis
clinical features of hydronephrosis.
61
Theme 4: Tumors of Renal/ excretory System
TEACHING
STRATEGY
Pathology
 Name benign and
malignant tumor of kidney.
14  Describe etiopathology, risk EXC-S2-Path-14
factor and morphology and Tumors of Kidney-I
clinical features of Renal
Cell Carcinoma. Interactive
SBQs & OSVE
 Classify urothelial tumor. Lecture
 Discuss etiology, EXC-S2-Path-15
15 pathogenesis, morphology,
Tumor of Urinary
clinical features and System-II
diagnosis of urothelial
tumors.
Describe gross and
EXC-S2-Path-16
microscopic features of benign
16 Kidney and urinary Practical OSPE & OSVE
& malignant kidney and urinary
bladder tumors
bladder tumors
Pharmacology
 Classify different types of
Diuretics.
 Describe the mechanism of
EXC-S2-Pharm-01 Interactive
17 action of Diuretics, SBQs & OSVE
Lecture
 Identify the clinical uses
and adverse effects of
Diuretics
62
9 REPRODUCTIVE SYSTEM MODULE-II
Introduction
Welcome to the Reproductive module. This exciting module will serve as building block and is very essential
Reproductive health is a state of complete physical, mental and social well-being in all matters relating to the
reproductive system. Reproductive Health is essential for peoples’ overall well-being. Hence Reproductive
health and specifically women’s reproductive health is given prime importance at a global level.
This module will address inflammatory, neoplastic and non-neoplastic diseases of female genital organs,
breast, sexually Transmitted Diseases and infertility. It will also address the inflammatory, non-neoplastic
and neoplastic diseases of male reproductive system.
Rationale
More than half of the population of Pakistan are females. Diseases related to female and male reproductive
systems constitute a large segment of medical practice in all countries. These diseases together with
pregnancy and its related disorders are the core teaching in this module. Reproductive module is expected
to build students basic knowledge about normal structure, development and diseases of reproductive system.
This will help the students to gain the knowledge about the etiology and pathogenesis of diseases of both
male and female reproductive system and methods of diagnosis these diseases.
This module will enable the students of fourth year to recognize the clinical presentations of common
reproductive diseases. The student will develop the understanding of the pathology, clinical presentation, and
diagnosis of reproductive disorders, normal pregnancy and its disorders.
Duration:
03 weeks
Learning Outcomes
At the end of this module students should be able to:
 Recall the anatomy & physiology of male and female reproductive system.
 Discuss the etiology of early pregnancy disorders.
 Differentiate the non-neoplastic and neoplastic lesions of male and female genital tract.
 Differentiate between primary and secondary amenorrhea and discuss the management of
infertility.
 Interpret the semen analysis report.
 Explain the clinical features diagnosis and management testicular tumors.
 Classify breast tumor and differentiate between non proliferative and proliferative breast lesions
Themes
Theme 1: Lesions of Female Genital Tract
Theme 4: Lesions of Male Genital Tract
63
STRATEGIES
Theme 1: Lesions of Female Genital Tract

TEACHING
STRATEGY
 Discuss congenital anomalies of

female genital tract
Rep-S2-Path-1
 Define sexually transmitted
Congenital
infections
anomalies &
1  Define Pelvic Inflammatory
Infections of
Disease
female genital
 List the organism causing genital tract
tract infection
 Discuss complications of PID
 Discuss the morphology,

pathogenesis and clinical
Rep-S2-Path-2
presentation of non-neoplastic &
Non-neoplastic
neoplastic vulvar conditions.
2 and neoplastic
 Explain the pathogenesis and conditions of
morphology of vaginal vulva and vagina
intraepithelial neoplasia and
squamous cell carcinoma
 Explain the infections of cervix
including acute & chronic Interactive
Rep-S2-Path-3 SBQs & OSVE
cervicitis and Endocervical Lecture
Non-neoplastic
Polyps
3 and neoplastic
 Discuss risk factors, conditions of
pathogenesis and morphology of cervix
cervical intraepithelial lesions
and cercvical carcinoma
 Discuss the etiology,
pathogenesis, morphology and
clinical features of Abnormal
uterine bleeding and
Anovulatory Cycle
Rep-S2-Path-4
 Explain the etiology, Functional
pathogenesis, morphology and
Endometrial
4 clinical features of acute and
Disorders &
chronic Endometritis,
Endometrial
Endometriosis and
Hyperplasia
Adenomyosis and Endometrial
Polyps
 Define Endometrial hyperplasia
and explain its etiology and
morphology
 Explain the procedure of pap
smear Rep-S2-Path-5
 Differentiate the normal and Pap smear
abnormal pap smear
pathogenesis, morphology and Rep-S2-Path-6 Interactive
6 SBQs & OSVE
clinical features of Carcinoma of Tumors of Uterus Lecture
the Endometrium
64
 Describe benign and malignant
tumors of myometrium
 Describe non neoplastic and
functional cyst of ovary Rep-S2-Path-7
7  Explain etiology, morphology Diseases of
and clinical presentation of ovary
polycystic ovarian disease
 Classify tumors of ovary
 Discuss the etiology, Rep-S2-Path-8
8 pathogenesis, morphology and Tumors of ovary
clinical features of ovarian
Interactive
tumors SBQs & OSVE
Lecture
pathogenesis and morphology of
hydatiform mole including
Rep-S2-Path-9
complete mole, partial mole and
Gestational
9 invasive mole
Trophoblastic
 Explain the pathogenesis and Diseases
morphology of choriocarcinoma
and placental site trophoblastic
tumor
 Describe the morphology, gross Rep-S2-Path-10
10 and microscopic features of Gestational Practical OSPE & OSVE
gestational tumors Tumor
Theme 2: Lesions of Male Genital Tract

TEACHING
STRATEGY
 Discuss congenital Rep-S2-Path-11
anomalies of male genital Congenital
tract anomalies and
11
 Describe inflammatory inflammation of
conditions of testis and testis and
epididymis epididymis
 Classify testicular tumors
pathogenesis, Rep-S2-Path-12
12
morphology and clinical Testicular Tumors
features of various types Interactive
SBQs & OSVE
of testicular tumors Lecture
 Explain the etiology and
Rep-S2-Path-13
morphology of prostatitis
Prostatitis & benign
13  Describe gross and prostatic
microscopic features and hyperplasia
complications of BPH
Describe etiology,
morphology, type and Rep-S2-Path-14
14 staging of carcinoma of Carcinoma of
prostate prostate
Explain the sample

collection, gross,
microscopic and chemical
Rep-S2-Path-15
15 examination of semen Practical OSPE & OSVE
Semen D/R
65
Pharmacology
 Enlist different estrogen
and antiestrogen
preparations Rep-S2-Pharm-1
16  Describe the Estrogen And
pharmacological effects, Antiestrogen
clinical uses and side
effects of these agents
 Enlist different types of
hormonal
contraceptives.
 Describe the mechanism Rep-S2-Pharm-2
17 of action of hormonal, Hormonal
contraceptives, their Contraceptives Lecture SBQs & OSVE
clinical uses and adverse
effects of hormonal
contraceptives.
 Describe the role of
endogenous oxytocin in
labour
 Describe the clinical Rep-S2-Pharm-3
18 conditions that may
require the exogenous Oxytocin
oxytocin
 Discuss the unwanted
effects of Oxytocin.
66
10 MUSCULOSKELETAL MODULE-II
Introduction
Welcome to the soft tissue and bone module. This exciting module will serve as building block and is very
This module covers the topics which are basic structure and function of bone, developmental
disorders of bone and cartilage, fractures, bone repair and osteomyelitis, arthritis, benign bone and
cartilage forming tumors, malignant bone and cartilage forming tumors, tumors of unknown origin
and soft tissue tumors. All these topics are interactive and helpful in understanding the soft tissue
and bone pathology.
Rationale
The soft tissue and bone module is designed with a compelling rationale, aiming to equip students with
essential knowledge and skills for various disciplines:
Duration:
02 weeks
Learning Outcomes
At the end of this module, the students will be able to understand pathological conditions, etiology, diagnostic
techniques, treatment planning, radiological interpretation, histopathology and clinical correlation.
Themes
Theme 1: Developmental Disorders of Bone & Cartilage, Basic Structure & Function of Bone.
Theme 2: Fractures, Osteomyelitis and Arthritis.
Theme 3: Benign Bone and Cartilage Forming Tumors, Malignant Bone and Cartilage Forming
Tumors and Tumors of Unknown Origin
Theme 4: Soft Tissue Tumors
67
STRATEGIES
Theme 1: Developmental Disorders of Bone & Cartilage, Basic
Structure & Function of Bone
TEACHING
STRATEGY
Pathology
 Functions of Bone
 Matrix
MSK-S2-Path-1
 Cells Basic Structure and
1
 Development Function of Bone
 Homeostasis and
Remodeling
 Diseases Associated with
Defects in Nuclear Proteins
and Transcription Factors
 Diseases Associated with Interactive
defects in Hormones and SBQs & OSVE
Lecture
Signal Transduction
MSK-S2-Path-2
Proteins
Developmental
2  Diseases Associated with Disorders Of Bone And
defects in Metabolic
Cartilage
Pathways (Enzymes, Ion
Channels, and
Transporters)
 Diseases Associated With
Defects in Degradation of
Macromolecules
Theme 2: Fracture, Osteomyelitis and Arthritis

TEACHING
STRATEGY
Pathology
 Define terms related to
fracture
 Describe mechanism of MSK-S2-Path-3
3 bone healing Fractures, bone repair
 Complications of fracture and osteomyelitis
 Pathophysiology of bone
infection (osteomyelitis)
 What is arthritis
 Define Osteoarthritis and Interactive
Rheumatoid Arthritis SBQs & OSVE
Lecture
 Explain pathophysiology of
osteoarthritis and
Rheumatoid Arthritis. MSK-S2-Path-4
4
 Describe the clinical Arthritis
features of osteoarthritis
and Rheumatoid Arthritis
 Treatment of osteoarthritis
and Rheumatoid Arthritis
 Crystal-Induced Arthritis.
68
Theme 3: Benign Bone and Cartilage Forming Tumors, Malignant
Bone and Cartilage Forming Tumors and Tumors of
Unknown Origin
TEACHING
STRATEGY
Pathology
 Osteoid Osteoma MSK-S2-Path-5
 Osteoblastoma Benign Bone and
5
 Osteochondroma cartilage Forming
Interactive
 Chondroma Tumors
Lecture
SBQs & OSVE
Gross and Microscopic MSK-S2-Path-6
6 Features Cartilage And Bone
Forming Tumors
 Osteosarcoma MSK-S2-Path-7
 Chondrosarcoma Malignant Bone and
 Tumors of Unknown Origin cartilage Forming
 Ewing Sarcoma Tumors
 Giant Cell Tumor Tumors of Unknown
 Aneurysmal Bone Cyst Origin
Theme 4: Soft Tissue Tumors

TEACHING
STRATEGY
Pathology
 Tumors of Adipose Tissue
 Lipoma
 Liposarcoma
 Fibrous Tumors
 Nodular Fasciitis
 Fibromatoses
 Superficial Fibromatosis MSK-S2-Path-8 Interactive
8 SBQs & OSVE
 Deep Fibromatosis Soft Tissue Tumors Lecture
(Desmoid Tumors)
 Skeletal Muscle Tumors
 Rhabdomyosarcoma
 Smooth Muscle Tumors
 Leiomyoma
 Leiomyosarcoma
Gross and Microscopic MSK-S2-Path-9
Features Soft Tissue Tumors
69
11 NEUROSCIENCE II
Introduction
Welcome to the Neuroscience module-II. This exciting module will serve as building block and is very
This module covers the topics which are Pathogenesis of infective and tumorous conditions of
nervous system like meningitis including bacterial, viral, tuberculous and fungal meningitis CSF
findings to differentiate various types of meningitis and brain tumors including both central and
peripheral nervous system tumors like gliomas, neuronal tumors, meningiomas, peripheral nerve
sheath tumors and others. All these topics are interactive and helpful in understanding the renal
pathology.
Rationale
Diseases of the nervous system are common all over the world. Timely diagnosis and management of acute
CNS problems like cerebrovascular accidents and infections prevents morbidity and mortality. Early diagnosis
and prompt treatment of ischemic, infective and tumorous conditions like meningitis, cerebrovascular
accident and brain tumors is important to reduce the occurrence of disability burden on community. After
Understanding the structure and function of nervous system and its relationship with pathophysiology of
diseases in neuroscience module-I, the students will be able to understand various infective and tumorous
conditions of nervous system the neuropathology module-II by integrating the teachings of basic and clinical
pathology, clinical medicine and surgery related to the disorders of the central and peripheral nervous system.
Duration:
02 weeks
Learning Outcomes
At the end of this module, the students will be able to understand common clinical problems like meningitis
and brain tumors and to correlate with Pathogenesis of diseases of meninges and brain parenchymal disease,
related investigations like CSF examination and biopsies
Themes
Theme 1: Meningitis Including Bacterial, Viral, Fungal and T.B Meningitis
Theme 2: Tumors of Central Nervous System
70
STRATEGIES
Theme 1: Inflammatory and Infective Diseases of CNS
TEACHING
STRATEGY
Pathology
 Define meningitis and
encephalitis
 Discuss common Central
Nervous System infections
including acute (pyogenic)
bacterial infections, acute
aseptic viral infections,
chronic bacterial meningo-
encephalitis, and fungal
meningo-encephalitis
Viral pathogens causing
1 meningitis, Enteroviruses, NS-S2-Path-1 Interactive
HSV-2, Arboviruses Inflammation and SBQs & OSVE
Lecture
Discuss pathogenesis of infections of CNS
cerebral malaria, Naeglaria
fowleri and Cysticercosis
Infection of Brain & Meninges
& CSF interpretation
List the most common
organisms that cause CNS
infection in different age
groups
Discuss CSF findings of
bacterial, tuberculous, viral
and fungal meningitis
Theme 2: Tumors of Central Nervous System

TEACHING
STRATEGY
Pathology
 Classify CNS tumors
according to WHO
classification
 List genetic mutations,
pathogenesis, morphology
and clinical features of brain
tumors NS-S2-Path-7 Interactive
2 SBQs & OSVE
 Including all types of Brain tumors Lecture
Glioma, Ependymoma,
Medulloblastoma and
Meningioma
 Discuss the metastatic
tumors to brain
Pharmacology
 Classify different types of NS-S2-Pharm-1
3
antiepileptic agents. Antiepiletics
71
 Describe the mechanism of
action, and adverse effects.
 Classify different types of
antipsychotic agents. NS-S2-Pharm-2
5
 Describe the mechanism of Antipsychotics
action, and adverse effects.
 Enlist different drugs that
are used for the treatment
NS-S2-Pharm-3
of Parkinson disease.
6 Treatment of Parkinson
 Describe their mechanism Disease
of action and adverse
effects.
 Discuss the
pathophysiology of migraine
headaches
NS-S2-Pharm-4
7  ⁠Discuss both Treatment of Migraine
pharmacologic and non-
pharmacologic treatment
strategies for migraine.
72
11 EXAMINATION ASSESSMENT
ASSESSMENT PLAN FOR EACH PAPER END OF YEAR INTERNAL TOTAL %AGE
ASSESMENT EVALUATION
THEORY (SBQS) 80% 20% 100%
PRACTICAL EXAM (OSVE; OSPE) 80%
ALLOCATION OF INTERNAL ASSESSMENT MARKS

COMPONENT SCORING MATRIX PERCENTAGE
ATTENDANCE (>90%=03; 89- 3%
THEORY 80%=02; 79-70%=01;<70%=00
Module tests 3%
Block tests 4%
10%
ATTENDANCE (>90%=03; 89- 3%
80%=02; 79-70%=01;<70%=00
PRACTICAL Module tests including ethics, 3%
conduct, practicals, assignments)
Block tests 4%
10%
TOTAL 20%
73
11 LEARNING RESOURCES
Pathology:
 TEXT BOOKS
 Robbins & Cotran, Pathologic Basis of Disease, 9th edition.
 Rapid Review Pathology, 4th edition by Edward F. Goljan MD
Pharmacology:
 TEXT BOOKS
 Lippincot Illustrated Pharmacology
 Basic and Clinical Pharmacology by Katzung
MicroBiology:
 TEXT BOOKS
 Review of Medical Microbiology and Immunology, Seventeenth Edition 17th
Edition by by Warren Levinson (Author), Peter Chin-Hong (Author), Elizabeth A.
Joyce (Author), Jesse Nussbaum (Author), Brian Schwartz (Author)
 Jawetz Melnick & Adelbergs Medical Microbiology 28 Edition
PARASITOLOGY:
 TEXT BOOKS
 Parasitology (Protozoology and Helminthology) by KD Chatterjee. 13th Edition
 A Guide to Human Parasitology by Blacklock and Southwell Hardcover 10th
edition
74

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STUDENT STUDY GUIDE

Integrated Modular System

SMALL GROUP TEACHING (SGT):

CASE- BASED LEARNING:

SKILLS LAB SESSION:

SELF DIRECTED LEARNING:

Prof. Dr. Samreen Memon

 Provide students a detailed framework of the modules organization

Prof. Dr. Ikram din Ujjan

Dr. Faheem Ahmed Memon

Dr. Sameena Gul

Mr. Mohal Lal

DEPARTMENT OF COMMUNITY MEDICINE

Subject in Module Proportion

After completion of this module student should be able to:

 Distinguish between innate

Theme 2: Diagnostic Approach to Infection

Theme 3: Pyogenic Bacteria

Theme 4: Pyogenic Bacteria

Theme 5: Pyrexia of Unknown Origin

79 100% 100 80% 20%

 Carry out practical work as instructed in an organized and safe manner.

Attitude & Behaviour

 To describe the Characteristic of

Theme 2: Pallorness (Anaemia)

Theme 3: Hemostatic Abnormalities

 Define & enlist the causes

Theme 5: Hematological Malignancies

Community 00 00 00 Competency level &

TOPICS WITH SPECIFIC LEARNING OBJECTIVES AND TEACHING

Theme 2: Chronic Diffuse Interstitial/ Restrictive Lung Diseases

 Explain the etiology, RESP-S2-Path-9

Theme 3: Vascular, Infectious & Pleural Diseases

Subject in Module Proportion of

Community 08 28 28 Competency level &

 Enlist pathologies involving cardiovascular system.

Clinical/ Practical skills

TOPICS WITH SPECIFIC LEARNING OBJECTIVES AND TEACHING

Theme 3: Myocardial Diseases

Theme 4: Diseases of Vessels

Theme 5: Pericardial and Endocardial Diseases, and Cardiac Tumors

Community 04 16 16 Competency level &

Theme 2: Disease of Stomach

Theme 6: Metabolic & Drug/Toxin Related Liver Diseases

Theme 8: Tumors of Liver and Gall Bladder

TOPICS WITH SPECIFIC LEARNING OBJECTIVES AND TEACHING

Theme 2: Non-Neoplastic & Neoplastic Diseases of Thyroid &

Theme 4: Non-Neoplastic & Neoplastic Diseases of Adrenal Gland

Community 04 10 10 Competency level &

Theme 1: Glomerular Conditions Including Glomerular Syndromes,

Theme 3: Obstructive Uropathy (Urolithiasis, Hydronephrosis)

Theme 1: Lesions of Female Genital Tract

 Discuss congenital anomalies of

 Discuss the morphology,

Theme 2: Lesions of Male Genital Tract

Explain the sample

Theme 2: Fracture, Osteomyelitis and Arthritis

Theme 4: Soft Tissue Tumors

Theme 2: Tumors of Central Nervous System