Fourth Year Second Semester

Course Code Course Title Credit

BMB 4201 Oncology 3
BMB 4203 Neurobiochemistry 3
BMB 4205 Genomics and Proteomics 3
BMB 4207 Food Technology 2
BMB 4209 Environmental Biochemistry 2
BMB 4210 Research Project 3
BMB 4212 In-plant Training/ Field Trip 2
BMB 4213 Viva-Voce 2
Total Credit 20

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 Course Code: BMB 4201
Course Title: Oncology
Full Marks: 100
Class Test/Assignment Marks: 20, Class Attendance Marks: 10
Semester Final Examination Marks: 70
Examination Duration: 3Hours
Credit: 03 , Class Hours: 42
(Admission Session: 2017-2018)

1. Introduction and overview of cancer:

a) Characteristics of normal and cancer cell, benign and malignant tumors, Nomenclature of
tumors, Differentiation and anaplasia, Characteristics of different types of cancer (Lymphoma,
leukemia, Hodgkin’s disease, non-Hodgkins lymphoma, bone cancer, skin cancer, breast cancer,
colon cancer, lung cancer, liver cancer and brain cancer).
b) Biology of tumor cell growth: Introduction, nature of tumor growth, growth rate and doubling
time, assessment of cell kinetics (tritiated thymidine and autoradiography and flow cytometry
techniques).

2. Molecular Biology of Cancer:

(a) Cell cycle and cancer: Mechanism of cell cycle regulation, mammalian cell cycle regulation,
cyclin, cyclin dependent protein kinases, inhibition of cyclin dependent kinases, regulation of E2F
transcription factors, cell cycle check points, apoptosis (programmed cell death), p53 gene in
apoptosis, BCL-2 in apoptosis.
(b) Tumor progression and metastasis: Tumor progression, clonal evolution, and molecular
genetics of tumor progression, pathogenesis of metastasis and spread of human cancers, molecular
mechanism of angiogenesis and metastasis (cell adhesion molecules, signal transduction by
inegrins, integrins in metastasis, proteolytic enzymes), oncogenes and metastasis, experimental
approaches in the study of metastasis.
(c) Oncogenes: Oncogenes, protooncogenes, and tumor suppressor genes and hereditary cancer.
identification of oncogenes, bioassay for oncogenes in tissue culture systems, functions of
oncogenes and tumor suppressor genes (signal transduction, extracellular growth factor, receptor
tyorosine kinases, Ras, Fos, Jun and API, c-Myc, REL, RBgene p53, ATM)
(d) Genetic basis of cancer: Chromosome nomenclature and methodology, terminology and
types of chromosome abberation in cancer, chromosome in solid tumor, the mechanism of genetic
respectability, relation between cancer incidence and age, cellular and genetic basis of cancer,
types of genetic risk factors for cancer, cytogenetics of hematological malignancies, cytogenetics
of solid tumors, Heritable cancer (Retinobalstoma and Knudsons hypothesis, the retinoblastoma
gene, colon carcinoma, breast carcinoma).
3. Etiology of cancer:
(a) Chemical factors: The nature of chemical carcinogens (chemistry and metabolism), biological
process in chemical carcinogenesis (multistep model in carcinogenesis) DNA adducts, and repair,
identification of carcinogens.
(b) Physical factors: Ionizing radiations, ultraviolet radiation carcinogenesis, asbestos,
hypothermia and erythema Ab Igne, electric and magnetic field.
(c) Viruses: DNA tumor viruses (SV40 virus, human adenovirus, human papiollma virus, Epstein
Bar virus, Hepatisis B virus), virus and kaposis sarcoma.

4. Tumor immunology: Tumor recognition and immune surveillance, human antitumor T-cell
response, tumor necrosis factor (TNF) and lymphokine activated killer cells, natural killer cells,
tumor antigens.
5. Laboratory diagnosis of cancer: Histologic and cytogenic methods, Immunocytochemistry,
molecular diagnosis, Flow cyrometry, tumor marker, ultrasonic scanning, nuclear medicine
procedure.

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Books Recommended:
1. The Basic Science of Oncology. lan F. Tannock; Richand p Hill.
2. Oxford Tent Book of Oncology Vol.1 & Voll. 11; Peckham, Pinedo, and Veronest.
3. Cancer, Principles & Practice of OncologyS. Vincent T. Devita,Jr.Samuel Hellman, Steven A.
Rosenberg.
4. The Molecular Biology of Cancer Busch.
5. Biochemistry of Human Cancer Bodansky.
6. Robbins Pathologic Basic of Disease. Romzi,S,Cotran.M.D. Vinay Kuman, stanley L. Robbins.
7. Microbiology. 2nd Edition, Lensing N.Prescott, John P. Harley. Donald A. Klein.
8. Medical Microbiology Mins; playfair,Roitt.Wakelin, Williams.
9. The Biology of Cancer,Edition: 2nd, Author(s):Robert A. Weinberg, Robert A Weinberg .
ISBN:9780815342205
10. Anticancer: A New Way of Life Audio CD – Audiobook, 2008
by David Servan-Schreiber (Author), Robert Fass (Narrator)
11. Textbook of Medical Oncology, Fourth Edition . DeVita, Hellman, and Rosenberg's Cancer:
Principles & Practice of Oncology (Cancer Principles and Practice of Oncology)
12. The MD Anderson Manual of Medical Oncology, Third Edition 3rd Edition
by Hagop M. Kantarjian (Author), Robert A. Wolff (Author)
13. The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic
Bio-Individualized Therapies
Dr. Nasha Winters ND FABNO L.Ac Dipl.OM (Author), Jess Higgins Kelley MNT (Author)
14. Basic Science of Oncology, Fifth Edition (McGraw-Hill International Editions) 5th Edition by Ian
Tannock (Author), Richard Hill (Author), Robert Bristow (Author), Lea Harrington (Author)
15. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, 6th Edition
by R. Ian Freshney

Course Code: BMB 4203

Course Title: Neurobiochemistry
Full Marks: 100
Class Test/Assignment Marks: 20, Class Attendance Marks: 10
Semester Final Examination Marks:70
Examination Duration: 3Hours
Credit: 03 , Class Hours: 42
(Admission Session: 2017-2018)

1. Brain: Different parts of brain and their functions, growth characteristics, cell of brain- neuron,
ganglia and their structure, hypothalamus, the sense, sense receptors- location and function, speech
thought, memory.
2. Brain as a specialized tissue: Structural, chemical and metabolic peculiarities-, difference
between growing and adult brain.
3. Gross and fine structure of the brain:
(a) Gross structure -different parts of the brain, their functions and growth characteristics (brief
treatment)
(b) Fine structure - cells of the brain, classification of neurons and glia, their structure, location
and function.
4 Synapse: Structure, their types – chemical and electrical, chemistry of neurotransmission (brief
treatment).
Nerve impulse and its conduction: Action potential, its ionic basis, sodium channel. Mechanism
of conduction along myelinated and unmyelinated nerve fibres, comparison of conduction velocity
along myelinated fibres.
5. Neurotransmission : Neurotransmitters, their metabolism, storage and release, calcium channel,
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 post synaptic receptors-their modulation with agonists and antagonists, neuropeptides.
6. Brain growth and development : Species, structural and cell type differences, neurogenesis and
gliogenesis, neuronal death and nervous system development.
7. Myelination: Myelin composition and maturation.
8. Metabolism of the developing brain: Energy metabolism, changes during development,
susceptibility of developing and adult brain to energy supply.
9. Brain development during malnutrition: Effect on cell proliferation, myelination and
synaptogenesis.
10. Brain diseases: Parkinson’s, Wilson’s, Huntington’s chorea, Alzhemer’s disease.
11. Biochemistry of memory: Short-term memory, long-term memory.

Books Recommended:

1. Understanding the Brain and its Development: A Chemical Approach. Harun K.M. Yusuf; World
Scientific Publishing Co. Pte. Ltd, Singapore, 1992.
2. Basic Neurochemistry; Molecular, Cellular, & Medical Aspects. Siegel George J; Agranoff
Barnard W, Alberts R. Wayne; Fisher Stephen K; Uhler Michael D; (6 th Edition). Lipincott
Williams and Wilkins, USA, 1999.
3. Fundamental Neuroscience. Michael J. Zigmond, Floyd E. Bloom, Story C. Landis, James L.
Roberts, Larry R. Squire; (2nd Edition) Elsevier Science, USA, 2003.
4. Principles of Neural Sciences by Eric R. Kendel, James H. Shwartz
5. Neuroscience by Dale Purves, George J. Augustine
6. Text Book of Medical Physiology. By Guyton and Hall
7. Human Physiology. By C.C. Chatterjee, Vol. 1 and 2.
8. Human Physiology. By Chakrabarti, Ghosh and Sahana.
9. Review of Medical Physiology. By William F. Ganong.

Course Code: BMB 4205

Course Title: Genomics and Proteomics
Full Marks: 100
Class Test/Assignment Marks: 20, Class Attendance Marks: 10
Semester Final Examination Marks: 70
Examination Duration: 3Hours
Credit: 03 , Class Hours: 42
(Admission Session: 2017-2018)

1. Introduction to Genomics: What is genomics? Genetics to genomics and its applications.

2. Genome Mapping: Karyotype, genetic map (linkage map), cytogenetic map and chromosome
banding, correlation of genetic and cytological map, nomenclature of chromosome banding
regions, physical map, compound chromosomes and Robertsonian chromosomes.
3. Genome Analysis: Analysis of genomic markers, such as, short tandem repeats (STRs) or
microsatellites, variable number of tandem repeats (VNTRs) or minisatellites, sequence tagged sites
(STS), expressed sequence tags (ESTs), human leukocyte antigens (HLA), gender markers,
mitochondrial genome markers using RFLP, RAPD, AFLP, PCR, fluorescent in situ hybridization
(FISH), genomic library construction, colony or plaque hybridization and screening, chromosome
walking.
4. The Human Genome: Background, Human Genome Project (HGP), genome sequencing strategy,
hierarchical shotgun sequencing, whole genome shotgun sequencing, features of the complete human
genome, variations in the human genome, known examples of SNPs that cause diseases,
pharmacogenomics, ethical consequences of genomic variations.

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5. Proteomics: What is proteomics? Proteome, applications, protein 3D structures, protein
identifications (2-hybrid system, 2-D gel electrophoresis, mass spectrometry/MALDI-TOF,
protein microarrays, other arrays), statistical models and stochastic processes in proteomics, signal
processing for proteomics, protein interaction networks, measuring protein interactions, large-
scale databases of information for protein sequences, structures, functions and interactions; mining
of protein databases, applications to human disease studies.

Books Recommended:
1. Principles of Gene Manipulation. R. W. Old and S. B. Primrose; (5th Edition) Blackwell Science,
2002.
2. Human Molecular Genetics. T. Strachman and A. P. Read; Garland Science, London, 2004.
3. Discovering Genomics, Proteomics, & Bioinformatics. Campbell & Heyer, Pearson Education.
2003.
4. GENOMES. T.A. BROWN (2nd and 3rd Edition)
5. Introduction to Genomics 2nd Edition by Arthur M. Lesk (Author)
6. Bioinformatics and Functional Genomics, 3rd Edition by Jonathan Pevsner (Author)
7. Genomics: The Science and Technology Behind the Human Genome Project
Charles R. Cantor, Cassandra L. Smith , ISBN: 978-0-471-59908-1
8. The Origins of Genome Architecture 1st Edition by Michael Lynch (Author)
9. Evolutionary Genomics and Proteomics 1st Edition by Mark D. Pagel and Andrew Pomiankowski
(Author)
10. The Human Genome Project: Cracking the Genetic Code of Life Softcover reprint of the original
1st ed. 1991 by Thomas F. Lee (Author)
11. Genomics and Proteomics: Principles, Technologies, and Applications. Devarajan Thangadurai,
Jeyabalan Sangeetha, 2015 by Apple Academic Press
ISBN 9781771881142
12. Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods, 2nd Edition,
Debasis Bagchi (Editor), Anand Swaroop (Editor), Manashi Bagchi (Editor)
ISBN: 978-1-118-93042-7, 2015
13. Principles of Proteomics (Advanced Texts) 1st Edition by Richard Twyman (Author)
14. Introducing Proteomics: From Concepts to Sample Separation, Mass Spectrometry and Data
Analysis, Josip Lovric ,ISBN: 978-0-470-03523-8, 2011
15. Introduction to Proteomics: Principles and Applications, Nawin C. Mishra, Günter Blobel
ISBN: 978-0-471-75402-2, 2010
16. Protein Biochemistry and Proteomics ,1st Edition, Authors: Hubert Rehm , eBook ISBN:
9780080458434 , Paperback ISBN: 9780120885459 , Imprint: Academic Press , 2006
17. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, 6th Edition
by R. Ian Freshney

Course Code: BMB 4207

Course Title: Food Technology
Full Marks: 100
Class Test/Assignment Marks: 20, Class Attendance Marks: 10
Semester Final Examination Marks: 70
Examination Duration: 3Hours
Credit: 02 , Class Hours: 28
(Admission Session: 2017-2018)

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1. General Introduction: Introduction and scope of Food Science, Technology and Food
Engineering.
2. Food preservation and processing:
Preservatives: Natural and chemical preservatives, mode of action of preservatives (sulphur
dioxide, benzoic acid, ascorbic acid and antioxidants), adverse effect of formalin and carbide and
alternative way to overcome the problem, Food preservation by irradiation and microwave
heating, storage.
Food additives: Definition, classifications, Structural and functional characteristics.
Food Texture: Principles of measurement of textural profiles of foods, Classification of sensory
characteristics, Instrumentation, sensory evaluation (ranking test, DUO-TRIO test, threshold test
and paired comparison test) of food, taste testing and some general principles of measurement of
quality.
3. Application of enzymes in food products: Advantages and application of using enzymes for
manufacture of food products (amylolitic, cellulolytic, pectolytic and other industrial enzymes).
4. Fermentation technology: Fermenter design and operation, aeration-agitation, microbial
respiration, temperature- pH control, batch Vs continuous operation types of fermenter, Aseptic
operation, Fermenter design, Novel reactor design, factors influencing microbial growth, water
activity and related problem, product extraction, typical industrial fermentation, alcohol, acid and
fermented food from global public health view point.
5. Food Safety and Security:
(a) Microbiological and hygienic aspects of food safety: Bacteria causing food infections –
Salmonella, Campylobacter, Escherichia coli O157:H7, Listeria monocytogenes and others, Food
intoxicating bacteria: Staphylococcus aureus, Bacillus cereus, Clostridium perfringens,
Clostridium botulinum, Viruses that can cause food borne illness.
(b) Chemical aspects of food safety: Basic principles about human toxicology, Food sensitivities, Food
intoxications, Residues-Veterinary drugs, Disinfectants, Contaminants -Environmental contaminants,
Process contaminants, Mycotoxins, Endogenous components.
6. Food Biotechnology: GM Food: Definition, scope, importance, objectives, marits, demerits and
limitations, Aspect of Bangladesh and world scenario of GMO/LMO.
7. Industrial Quality Control and Assurance: Introduction to Quality control and total Quality
control and Assurance in the food Industry, Good manufacturing practices (GMP), hygiene
practice.

Books Recommended:
1. AQA GCSE Design and Technology: Food Technology , 2014 by Jenny Hotson (Author), Jane
Girt (Author), Garry Littlewood (Author)
2. Food Texture and Viscosity: Concept and Measurement ,2nd Edition, Authors: Malcolm Bourne
,eBook ISBN: 9780080491332 , Hardcover ISBN: 9780121190620 , Imprint: Academic Press ,
2002
3. Computer Applications in Food Technology: Use of Spreadsheets in Graphical, Statistical, and
Process Analyses, Author: R.Paul Singh Academic Press, Inc. Orlando, FL, USA ©1996 ,
ISBN:0126463824

4. Food Process Engineering and Technology , 2nd Edition, Authors: Zeki Berk
eBook ISBN: 9780124159860 , Hardcover ISBN: 9780124159235 , Imprint: Academic Press ,
2013
5. Introduction to Food Science and Technology , 2nd Edition, Series Editors: B.S. Schweigert John
Hawthorn , Authors: G.F. Stewart Maynard Amerine , eBook ISBN: 9780323138598 , Imprint:
Academic Press , 1982
6 Structure–Function Properties of Food Proteins , A volume in Food Science and Technology ,
Author(s): Lance G. Phillips and Steve L Taylor, ISBN: 978-0-12-554360-6
7. Statistical Methods in Food and Consumer Research , 2nd Edition
Authors: Maximo Gacula, Jr. Jagbir Singh Jian Bi Stan Altan ,eBook ISBN: 9780080920337 ,
Hardcover ISBN: 9780123737168 , Imprint: Academic Press , 2008
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8. Skills in Food Technology, 1997 by Jenny Ridgwell (Author)
9. Food Preservation Process Design , 1st Edition, Authors: Dennis Heldman
eBook ISBN: 9780080919652 , Hardcover ISBN: 9780123724861 , Imprint: Academic Press ,
2011
10. Handbook of Food Science, Technology, and Engineering - 4 Volume Set, Y. H. Hui, Frank
Sherkat, 2005 by CRC Press ,ISBN 9780849398476
11. Food Science and Technology by Bhupendra Singh Khatkar, 2007

Course Code: BMB 4209

Course Title: Environmental Biochemistry
Full Marks: 100
Class Test/Assignment Marks: 20, Class Attendance Marks: 10
Semester Final Examination Marks: 70
Examination Duration: 3Hours
Credit: 02 , Class Hours: 28
(Admission Session: 2017-2018)

1. Introduction: Concept of environment and its relation to society and principles of environment.
2. Ecological concept and natural resources: Introduction to ecological perspectives,
environmental components, levels of organization of environmental componenets, eco system
processes, environmental changes and climate changes.
3. Air pollution: Particulate matter, compounds of carbon, sulphur, nitrogen and their interactions,
methods of their estimation, their effect on atmosphere.
4. Water pollution: Types of water bodies and their general characteristics, major pollutants in
domestic and industrial water, methods of their estimation, effects of pollutants on plants and
animals, Pollution of water by micro organisms, bacteriological analysis of water-sewage
treatment-home and industrial.
5. Agricultural pollution: Introduction, nutrient cycle, nutrient losses, waste production in
agricultural farms.
6. Chemical toxicology:
Toxic chemicals in the environment, impact of toxic chemicals on enzymes, Biochemical effects
of As, Pb, Cd, Hg, Biochemical effects of CO, NOx, SOx, pesticides, Bioremediation for
environmental cleanup, Biomass utilization and microbial degradation of Xenobiotics.
7. Minimization of pollution: Benefits of pollution minimization, elements of pollution
minimization, controlling of life cycle in pollution minimization and pollution minimization
techniques.

Books Recommended:
1. Environmental Geochemistry of Potentially Toxic Metals, Authors: Siegel, Frederic R.
2. Principles of Environmental Geochemistry 1st Edition by Nelson Eby (Author)
3. Ecological Biochemistry: Environmental and Interspecies Interactions, Gerd-Joachim Krauss,
Dietrich H. Nies ,ISBN: 978-3-527-31650-2, 2014, Wiley-Blackwell
4. Environmental and Low Temperature Geochemistry, Peter Ryan , ISBN: 978-1-4051-8612-4,

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 2014, Wiley-Blackwell
5. Introduction to Ecological Biochemistry ,4th Edition, Authors: J. Harborne , eBook ISBN:
9780080918587 ,eBook ISBN: 9780080918594 , Hardcover ISBN: 9780123246851 , Paperback
ISBN: 9780123246868 ,Imprint: Academic Press , 2014
6. Soil Microbiology, Ecology and Biochemistry , 4th Edition,Authors: Eldor Paul
Hardcover ISBN: 9780124159556 , eBook ISBN: 9780123914118 , Imprint: Academic Press ,
Published Date: 12th November 2014

Course Code: BMB 4210

Course Title: Research Project
Full Marks: 100
Project Marks: 50, Research Performance Marks: 20
Defense/ Viva-Voce Marks: 30
Credit: 03
(Admission Session: 2017-2018)

Students will submit a project report on particular topic and teacher will supervise the whole work.
Student will appear at the viva-voce and will have to defend his/her research activities before the
examination committee.

Course Code: BMB 4212

Course Title: In-plant Training/Field Trip
Full Marks: 100
Report Marks: 50, Overall Performance Marks: 20
Quiz Marks: 20, Viva-Voce Marks: 10
Credit: 02
(Admission Session: 2017-2018)

Each student will be required to visit a clinical, pharmaceutical and research institute or relevent
industry to acquire practical knowledge and submit a short report.

Course Code: BMB 4213

Course Title: Viva-Voce
Full Marks: 100
Credit: 2
(Admission Session: 2017-2018)

All students will appear at the Viva-Voce.

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