Tumor Site Gross Micro Effect XR

Well circumcriubed
Disarranged Havrssion In outer table = disfiguring
Compact Skull Hard
system In inner = brain compression
Sessile
osteoma

Cancelloous Epiphyseal cartilage

Mass of bone covered by Bony matrix covered by Pressure effect
/Osteochondroma of long bones
cartilage cartilage Malignant transformation
benign

Round
Cancellous part of long bone
Osteoid near joints
Not exceeding 1 cm Vascular osteoid material Pain

Fibrous capsule sending

Capsullated
septa
Lobulated Secondary changes
Chondroma Flat bones
C/S hyaline blue
Chondrocytes in lacuna with
Malignant transformation
hyaline matrix
Locally malignant

Soup bubble
2 cell
Expansion of bone Reoccurance
End of large bones - round cell with
Leads to egg shell crackling Malignant transformation is
Giant cell tumor 20-40 Y
sensation
malignant criteria
rare
- giant calls
multinucleated

Sunray appearance
End of long bones inflilterative mass
Abnormal osteocytes Death in 3-5 Y codman triangle
Osteosarcoma 10-25 males Raising periosteum causes
Different matrix Infiltration to soft tissues
In paget disease / radiation formation of spacules
osteochondroma

Onion skin appearance

Raising periosteum Large cell
Diaphysis
Chondrosarcoma Formation of multiple With deep basophilic N
10-25 Y
layers of bone Little cytoplasm
malignant

Flat bones
Chondroma Same as chondroma
Ewing Same as chondroma but
Or osteochondroma Or spindle cells Better prognosis
infilterative
30-60 Y

 B cell leukemia
 myelophthsic anemia &
Flat bones thrombocytopenia
Plasma cells in different
Multiple myeloma Above 40 Y Multiple round masses  amyloidosis
stages
 bence Jones proteinuria
 nephrosis
 death in 3-5 Y