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    Ferric Ammonium Citrate

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    frimpongjeremy
    This document provides information on ferric ammonium citrate including its synonyms, definition, description, functional uses, characteristics, identification tests, purity standards, and assay method. It establishes permissible levels of iron, citrate, sulfates, and lead and describes analytical procedures.

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    Ferric Ammonium Citrate

    Uploaded by

    frimpongjeremy
    11 views2 pages
    This document provides information on ferric ammonium citrate including its synonyms, definition, description, functional uses, characteristics, identification tests, purity standards, and assay method. It establishes permissible levels of iron, citrate, sulfates, and lead and describes analytical procedures.

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    This document provides information on ferric ammonium citrate including its synonyms, definition, description, functional uses, characteristics, identification tests, purity standards, and assay method. It establishes permissible levels of iron, citrate, sulfates, and lead and describes analytical procedures.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    11 views2 pages

    Ferric Ammonium Citrate

    Uploaded by

    frimpongjeremy
    This document provides information on ferric ammonium citrate including its synonyms, definition, description, functional uses, characteristics, identification tests, purity standards, and assay method. It establishes permissible levels of iron, citrate, sulfates, and lead and describes analytical procedures.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    FERRIC AMMONIUM CITRATE

    Prepared at the 28th JECFA (1984), published in FNP 31/2 (1984) and in
    FNP 52 (1992). Metals and arsenic specifications revised at the 63rd
    JECFA (2004). A PMTDI of 0.8 mg/kg bw for iron was established at the
    29th JECFA (1985).

    SYNONYMS Iron ammonium citrate, ammonium ferric citrate, ammonium iron citrate,
    ammonium iron (III) citrate, INS No. 381

    DEFINITION A complex salt of undetermined structure, composed of iron, ammonia


    and citric acid; there are two types of salts - brown and green - containing
    different amounts of iron

    Chemical names Ferric ammonium citrate, ammonium iron (III) citrate

    Assay Not less than 16.5% and not more than 22.5% of iron (Fe) for the brown
    salt, and not less than 14.5% and not more than 16.0% of iron (Fe) for
    the green salt.

    DESCRIPTION Brown salt: thin, transparent brown, reddish brown, or garnet red scales
    or granules, or a brownish yellow powder; odourless or has a slight
    ammoniacal odour

    Green salt: thin, transparent green scales, granules, powder, or


    transparent green crystals; odourless

    FUNCTIONAL USES Nutrient, dietary supplement (brown salt)


    Nutrient, dietary supplement, anticaking agent for sodium chloride(green
    salt)

    CHARACTERISTICS

    IDENTIFICATION

    Solubility (Vol. 4) Very soluble in water; insoluble in ethanol

    Test for iron and ferric salts Ignite 0.5 g of the sample gently, and dissolve the residue in 5 ml of
    dilute hydrochloric acid TS. The solution gives positive tests for iron and
    for ferric salts.

    Test for citrate To 5 ml of a 1-in-10 solution of the sample add 0.3 ml of potassium
    permanganate TS and 4 ml of mercuric sulfated TS and then heat the
    mixture to boiling. A white precipitated forms.

    Test for ferric and Dissolve 0.5 g of the sample in 5 ml of water, and add 5 ml of sodium
    ammonium salt hydroxide TS. A reddish brown precipitate forms and ammonia is evolved
    when the mixture is heated.

    PURITY

    Ferric citrate Add potassium ferrocyanide TS to a 1 in 100 solution of the sample. No


    blue precipitation forms.
    Oxalate Transfer 1 g of the sample into a 125-ml-separator, dissolve in 10 ml of
    water, add 2 ml of hydrochloric acid, and extract successively with 50-ml
    portion and one 20-ml portion of ether. Transfer the combined ether
    extracts to a 150-ml beaker, add 10 ml of water, and remove the ether by
    evaporation on a steam bath. Add 1 drop of glacial acetic acid and 1 ml
    of calcium acetate solution (1 in 20) to the residual aqueous solution. No
    turbidity is produced within 5 min.

    Sulfates Not more than 0.3%


    Dissolve a 100 mg sample in 1 ml of diluted hydrochloric acid TS, and
    dilute to 30 to 40 ml with water. Proceed as directed in the Limit Test for
    Sulfates, beginning with the addition of 3 ml of barium chloride TS. Any
    turbidity produced does not exceed that shown in a control containing 0.6
    ml of 0.01 N sulfuric acid.

    Lead (Vol. 4) Not more than 2 mg/kg


    Determine using an atomic absorption technique appropriate to the
    specified level. The selection of sample size and method of sample
    preparation may be based on the principles of the method described in
    Volume 4, “Instrumental Methods.”

    METHOD OF Transfer about 1 g of the sample, accurately weighed, into a 250 ml


    ASSAY glass-stoppered Erlenmeyer flask, and dissolve in 25 ml of water and 5
    ml of hydrochloric acid. Add 4 g of potassium iodide, stopper, and allow
    to stand protected from light for 15 min. Add 100 ml of water, and titrate
    the liberated iodine with 0.1 N sodium thiosulfate, using starch TS as the
    indicator. Perform a blank determination and make any necessary
    correction. Each ml of 0.1 N sodium thiosulfate is equivalent to 5.585 mg
    of iron (Fe).

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