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Published on: 01-Feb-2024 @2024 USPC

Not official text of the USP-NF. Please refer to the currently official version of the individual Reagent, Solution, or Indicator document for compliance purposes

Chromatographic Columns
The following list of packings (L), phases (G), and supports L13—Trimethylsilane chemically bonded to porous silica
(S) is intended to be a convenient reference for the particles, 3 to 10 μm in diameter.
chromatographer.
[NOTE—Particle sizes given in this listing are those generally L14—Silica gel having a chemically bonded, strongly basic
provided. Where other, usually finer, sizes are required, quaternary ammonium anion-exchange coating, 5 to 10 µm
the individual monograph specifies the desired particle in diameter.
size. Within any category of packings or phases listed
below, there may be a wide range of columns available. L15—Hexylsilane chemically bonded to totally porous silica
Where it is necessary to define more specifically the particles, 3 to 10 μm in diameter.
chromatographic conditions, the individual monograph
so indicates.] L16—Dimethylsilane chemically bonded to porous silica
Packings particles, 5 to 10 μm in diameter.

Change to read: L17—Strong cation-exchange resin consisting of sulfonated

cross-linked styrene–divinylbenzene copolymer in the
L1—Octadecyl silane chemically bonded to porous or hydrogen form, 6 to 12 µm in diameter.
nonporous silica ▲particles, superficially porous
particles,▲ (USP 1-Aug-2022) or ceramic microparticles, 1.5–10 µm L18—Amino and cyano groups chemically bonded to porous
in diameter, or a monolithic silica rod. silica particles, 3 to 10 μm in diameter.

L2—Octadecyl silane chemically bonded to silica gel of a L19—Strong cation-exchange resin consisting of sulfonated
controlled surface porosity that has been bonded to a solid cross-linked styrene-divinylbenzene copolymer in the calcium
spherical core, 30 to 50 μm in diameter. form, 5–15 µm in diameter.

Change to read: L20—Dihydroxypropane groups chemically bonded to

porous silica or hybrid particles, 1.5–10 µm in diameter, or a
L3—Porous silica particles ▲or superficially porous monolithic silica rod.
particles,▲ (USP 1-Aug-2022) 1.5–10 µm in diameter, or a monolithic
silica rod. L21—A rigid, spherical styrenedivinylbenzene copolymer 3 to
30 µm in diameter.
L4—Silica gel of controlled surface porosity bonded to a solid
spherical core, 30 to 50 μm in diameter. L22—A cation-exchange resin made of porous polystyrene gel
with sulfonic acid groups, 5–15 µm in diameter.
L5—Alumina of controlled surface porosity bonded to a solid
spherical core, 30 to 50 μm in diameter. L23—An anion-exchange resin made of porous
polymethacrylate or polyacrylate gel with quaternary
L6—Strong cation-exchange packing–sulfonated ammonium groups, 7–12 µm in size.
fluorocarbon polymer coated on a solid spherical core, 30 to
50 μm in diameter. L24—Polyvinylalcohol chemically bonded to porous silica
particle, 5 µm in diameter. [NOTE—Available as YMC-Pack
L7—Octylsilane chemically bonded to totally porous or PVA-SIL manufactured by YMC Co., Ltd. and distributed by
superficially porous silica particles, 1.5–10 μm in diameter, or a Waters Corp. (www.waters.com).]
monolithic silica rod.
L25—Packing having the capacity to separate compounds
L8—An essentially monomolecular layer of aminopropylsilane with a molecular weight range from 100–5000 (as determined
chemically bonded to totally porous silica gel support, 1.5–10 by polyethylene oxide), applied to neutral, anionic, and
μm in diameter, or a monolithic silica rod. cationic water-soluble polymers. A polymethacrylate resin
base, cross-linked with polyhydroxylated ether (surface
L9—Irregular or spherical, totally porous silica gel having a contained some residual carboxyl functional groups) was
chemically bonded, strongly acidic cation-exchange coating, found suitable.
3 to 10 µm in diameter.
L26—Butyl silane chemically bonded to totally porous or
Change to read: superficially porous silica particles, 1.5–10 μm in diameter.
L10—Nitrile groups chemically bonded to porous silica L27—Porous silica particles, 30 to 50 μm in diameter.
particles ▲or superficially porous particles,▲ (USP 1-Aug-2022) 1.5–
10 μm in diameter, or a monolithic silica rod. L28—A multifunctional support, which consists of a high
purity, 100 Å, spherical silica substrate that has been bonded
Change to read: with anionic exchanger, amine functionality in addition to a
conventional reversed phase C8 functionality.
L11—Phenyl groups chemically bonded to porous ▲or
superficially porous▲ (USP 1-Aug-2022) silica particles, 1.5–10 μm in L29—Gamma alumina, reverse-phase, low carbon percentage
diameter, or a monolithic silica rod. by weight, alumina-based polybutadiene spherical particles, 5
μm in diameter with a pore volume of 80 Å.
L12—A strong anion-exchange packing made by chemically
bonding a quaternary amine to a solid silica spherical core,
30 to 50 μm in diameter.
Printed on: Sat Feb 24 2024, 02:13:32 AM (EST) Printed by: Umesh Kulkarni Published on: 01-Feb-2024 @2024 USPC
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L30—Ethyl silane chemically bonded to totally porous silica diameter. [NOTE—Available as CarboPac MA1 and distributed
particles, 3 to 10 μm in diameter. by Dionex Corp. (www.dionex.com).]

L31—A hydroxide-selective, strong anion-exchange L48—Sulfonated, cross-linked polystyrene with an outer layer
resin-quaternary amine bonded on latex particles attached of submicron, porous, anion-exchange microbeads, 5 to 15
to a core of 8.5-μm macroporous particles having a pore size µm in diameter.
of 2000 Å and consisting of ethylvinylbenzene cross-linked
with 55% divinylbenzene. L49—A reversed-phase packing made by coating a thin layer
of polybutadiene onto spherical porous zirconia particles, 3 to
L32—A chiral ligand-exchange packing–L-proline copper 10 µm in diameter. [NOTE—Available as Zirchrom PBD from
complex covalently bonded to irregularly shaped silica www.zirchrom.com.]
particles, 5 to 10 μm in diameter.
L50—Multifunction resin with reversed-phase retention and
L33—Packing having the capacity to separate dextrans by strong anion-exchange functionalities. The resin consists of
molecular size over a range of 4,000 to 500,000 Da. It is ethylvinylbenzene, 55% cross-linked with divinylbenzene
spherical, silica-based, and processed to provide pH stability. copolymer, 3 to 15 µm in diameter, and a surface area not less
[NOTE—Available as TSK-GEL G4000SWxl from Tosoh than 350 m2 per g. Substrate is coated with quaternary
Bioscience (www.tosohbioscience.com).] ammonium functionalized latex particles consisting of styrene
cross-linked with divinylbenzene. [NOTE—Available as
L34—Strong cation-exchange resin consisting of sulfonated OmniPac PAX-500 and distributed by Dionex Corp.
cross-linked styrene–divinylbenzene copolymer in the lead (www.dionex.com).]
form, 7 to 9 μm in diameter.
L51—Amylose tris-3,5-dimethylphenylcarbamate-coated,
L35—A zirconium-stabilized spherical silica packing with a porous, spherical, silica particles, 3–10 µm in diameter.
hydrophilic (diol-type) molecular monolayer bonded phase [NOTE—Available as Chiralpak AD from Chiral Technologies,
having a pore size of 150 Å. Inc. (www.chiraltech.com).]

L36—A 3,5-dinitrobenzoyl derivative of L-phenylglycine L52—A strong cation-exchange resin made of porous silica
covalently bonded to 5-μm aminopropyl silica. with sulfopropyl or sulfoethyl groups, 1–10 µm in diameter.

L37—Packing having the capacity to separate proteins by L53—Weak cation-exchange resin consisting of
molecular size over a range of 2,000 to 40,000 Da. It is a ethylvinylbenzene, 55% cross-linked with divinylbenzene
polymethacrylate gel. copolymer, 3 to 15 µm diameter. Substrate is surface grafted
with carboxylic acid and/or phosphoric acid functionalized
L38—A methacrylate-based size-exclusion packing for monomers. Capacity not less than 500 µEq/column.
water-soluble samples. [NOTE—Available as IonPac CS14 distributed by Dionex Corp.
(www.dionex.com).]
L39—A hydrophilic polyhydroxymethacrylate gel of totally
porous spherical resin. L54—A size exclusion medium made of covalent bonding of
dextran to highly cross-linked porous agarose beads, 5–15 µm
L40—Cellulose tris-3,5-dimethylphenylcarbamate-coated, in diameter.
porous silica particles, 3–20 μm in diameter. [NOTE—Available as Superdex Peptide HR 10/30 from
www.gelifesciences.com.]
L41—Immobilized α1-acid glycoprotein on spherical silica
particles, 5 μm in diameter. L55—A strong cation-exchange resin made of porous silica
coated with polybutadiene–maleic acid copolymer, about 5
L42—Octylsilane and octadecylsilane groups chemically µm in diameter. [NOTE—Available as IC-Pak C M/D from Waters
bonded to porous silica particles, 5 μm in diameter. Corp. (www.waters.com).]

Change to read: L56—Propyl silane chemically bonded to totally or

superficially porous silica particles, 3–10 µm in diameter.
L43—Pentafluorophenyl groups chemically bonded to [NOTE—Available as Zorbax SB-C3 from Agilent Technologies
▲
porous or superficially porous▲ (USP 1-Aug-2022) silica particles (www.agilent.com/chem).]
by a propyl spacer, 1.5–10 μm in diameter.
L57—A chiral-recognition protein, ovomucoid, chemically
L44—A multifunctional support, which consists of a high bonded to silica particles, about 5 µm in diameter, with a pore
purity, 60 Å, spherical silica substrate that has been bonded size of 120 Å. [NOTE—Available as Ultron ES-OVM from Agilent
with a cationic exchanger, sulfonic acid functionality in Technologies (www.agilent.com/chem).]
addition to a conventional reversed phase C8 functionality.
L58—Strong cation-exchange resin consisting of sulfonated
L45—Beta cyclodextrin, R,S-hydroxypropyl ether derivative, cross-linked styrene-divinylbenzene copolymer in the sodium
bonded to porous silica particles, 3–10 µm in diameter. form, about 6 to 30 µm in diameter. [NOTE—Available as
Aminex HPX-87N from Bio-Rad Laboratories, (2000/01
L46—Polystyrene/divinylbenzene substrate agglomerated catalog, #125-0143) www.bio-rad.com.]
with quaternary amine functionalized latex beads, about 9 to
11 μm in diameter. L59—Packing for the size-exclusion separation of proteins
(separation by molecular weight) over the range of 5 to
L47—High-capacity anion-exchange microporous substrate, 7000 kDa. The packing is a spherical 1.5- to 10-µm silica or
fully functionalized with trimethlyamine groups, 8 μm in hybrid packing with a hydrophilic coating.
Printed on: Sat Feb 24 2024, 02:13:32 AM (EST) Printed by: Umesh Kulkarni Published on: 01-Feb-2024 @2024 USPC
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Change to read: [NOTE—Available as RSpak DE-613 from

www.shodex.com.]
L60—Spherical, porous ▲or superficially porous▲ (USP 1-Aug-2022)
silica ▲particles,▲ (USP 1-Aug-2022) 10 µm or less in diameter, the L72—(S)-phenylglycine and 3,5-dinitroanaline urea linkage
surface of which has been covalently modified with alkyl amide covalently bonded to silica.
groups and endcapped. ▲▲ (USP 1-Aug-2022) [NOTE—Available as Sumichiral OA-3300, distributed by
www.phenomenex.com.]
L61—A hydroxide selective strong anion-exchange resin
consisting of a highly cross-linked core of 13-µm microporous Change to read:
particles having a pore size less than 10 Å units and consisting
of ethylvinylbenzene cross-linked with 55% divinylbenzene L73—A rigid spherical polydivinylbenzene particle, 5 to 10 µm
with a latex coating composed of 85-nm diameter microbeads in diameter.▲▲ (ERR 1-Aug-2018)
bonded with alkanol quaternary ammonium ions (6%).
[NOTE—Available as Ion Pac AS-11 and AG-11 from Dionex L74—A strong anion-exchange resin consisting of a highly
(www.dionex.com).] cross-linked core of 7- µm macroporous particles having a
100-Å average pore size and consisting of ethylvinylbenzene
Change to read: cross-linked with 55% divinylbenzene and an anion-exchange
layer grafted to the surface, which is functionalized with alkyl
L62—C30 silane bonded phase on a fully porous spherical quaternary ammonium ions. [NOTE—Available as IonPac
silica ▲or on superficially porous particles,▲ (USP 1-Aug-2022) 3–15 AS14A from Dionex (www.dionex.com).]
µm in diameter.
L75—A chiral-recognition protein, bovine serum albumine
L63—Glycopeptide teicoplanin linked through multiple (BSA), chemically bonded to silica particles, about 7 µm in
covalent bonds to a 100-Å units spherical silica. diameter, with a pore size of 300 Å.
[NOTE—Available as Astec Chirobiotic T from Supelco
(www.sigmaaldrich.com).] L76—Silica-based, weak cation-exchange material, 5 µm in
diameter. Substrate is surface polymerized polybutadiene–
L64—Strongly basic anion-exchange resin consisting of 8% maleic acid to provide carboxylic acid functionalities. Capacity
cross-linked styrene-divinylbenzene copolymer with a not less than 29 µEq/column. [NOTE—Available as Metrosep
quaternary ammonium group in the chloride form, 45 to 180 C4-250 from Metrohm (www.metrohm.com).]
µm in diameter.
[NOTE—A suitable grade is available as AG 1-X8 resin L77—Weak cation-exchange resin consisting of
chloride form from www.discover.bio-rad.com.] ethylvinylbenzene, 55% cross-linked with divinylbenzene
copolymer, 6- to 9-µm diameter. Substrate is surface grafted
L65—Strongly acidic cation-exchange resin consisting of 2% with carboxylic acid functionalized groups. Capacity is not less
sulfonated cross-linked styrene-divinylbenzene copolymer than 500 µEq/column (4 mm × 25 cm).
with a sulfonic acid group in the hydrogen form, 45–250 µm
in diameter. L78—A silane ligand that consists of both reversed-phase (an
[NOTE—A suitable grade is available as AG 50W-X2 resin alkyl chain longer than C8) and anion-exchange (primary,
hydrogen form from www.bio-rad.com.] secondary, or tertiary amino groups) functional groups
chemically bonded to porous or nonporous silica or ceramic
L66—A crown ether coated on a 5-µm particle size silica gel microparticles, 1.0–50 µm in diameter, or a monolithic rod.
substrate. The active site is (S)-18-crown-6-ether. [NOTE—Available as Acclaim Mixed-Mode WAX-1 from
[NOTE—Available as Crownpak CR(+) from Thermo Fisher (www.thermofisher.com).]
www.chiraltech.com.]
L79—A chiral-recognition protein, human serum albumin
L67—Porous vinyl alcohol copolymer with a C18 alkyl group (HSA), chemically bonded to silica particles, about 5 µm in
attached to the hydroxyl group of the polymer, 2 to 10 µm in diameter.
diameter.
[NOTE—Available as apHera C18 from Supelco L80—Cellulose tris(4-methylbenzoate)-coated, porous,
(www.sigmaaldrich.com).] spherical, silica particles, 5–20 µm in diameter.

L68—Spherical, porous silica, 10 µm or less in diameter, the L81—A hydroxide-selective, strong anion-exchange resin
surface of which has been covalently modified with alkyl amide consisting of a highly cross-linked core of 9-µm porous
groups and not endcapped. particles having a pore size of 2000 Å and consisting of
[NOTE—Available as SUPELCOSIL SUPLEX pKb-100 from ethylvinylbenzene cross-linked with 55% divinylbenzene
Supelco (www.sigmaaldrich.com).] with a latex coating composed of 70-nm diameter microbeads
(6% cross-linked) bonded with alkanol quaternary
L69—Ethylvinylbenzene/divinylbenzene substrate ammonium ions.
agglomerated with quaternary amine functionalized 130-nm [NOTE—A suitable column is Dionex IonPac AS11-HC
latex beads, about 6.5 µm in diameter. available from www.thermofisher.com.]
[NOTE—Available as CarboPac PA20 from
www.dionex.com.] L82—Polyamine chemically bonded to cross-linked polyvinyl
alcohol polymer, 5 µm in diameter.
L70—Cellulose tris(phenyl carbamate) coated on 5-µm silica. [NOTE—Available as Asahipak NH2P-50 from
[NOTE—Available as Chiralcel OC-H from www.shodex.com.]
www.chiraltech.com.]
L83—A hydroxide-selective, strong anion-exchange
L71—A rigid, spherical polymetacrylate, 4 to 6 µm in resin-quaternary amine bonded on latex particles attached
diameter. to a core of 10.5-µm microporous particles of 10-Å pore size,
Printed on: Sat Feb 24 2024, 02:13:32 AM (EST) Printed by: Umesh Kulkarni Published on: 01-Feb-2024 @2024 USPC
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and consisting of ethylvinylbenzene cross-linked with 55% L97—Weak cation-exchange resin consisting of a highly
divinylbenzene. cross-linked core of 5.5-µm porous particles having a pore size
of 2000 Å units and consisting of ethylvinylbenzene
L84—Weak cation-exchange resin consisting of cross-linked with 55% divinylbenzene. Substrate is surface
ethyvinylbenzene, 55% cross-linked with divinylbenzene grafted with carboxylic acid functionalized groups. Capacity
copolymer, 5 µm in diameter. Substrate is surface grafted with NLT 2400 µEq/column (4-mm × 25-cm).
carboxylic acid functionalized groups. Capacity NLT 8400
µEq/column (5-mm × 25-cm). L98—Weak cation-exchange resin consisting of a highly
cross-linked core of 8.0-µm microporous particles having an
L85—A silane ligand that consists of both reversed-phase (an average pore size of 10 Å units and consisting of
alkyl chain longer than C8) and weak cation-exchange ethylvinylbenzene cross-linked with 55% divinylbenzene.
(carboxyl groups) functional groups chemically bonded to Substrate is surface grafted with carboxylic acid functionalized
porous or nonporous particles, 1.0–50 µm in diameter. groups. Capacity of NLT 46 µEq/column (4-mm × 5-cm).

Change to read: L99—Amylose tris-(3,5-dimethylphenylcarbamate),

immobilized on porous, spherical, silica particles, 3–5 µm in
L86—Fused core particles with a highly polar ligand diameter.
possessing five hydroxyl groups tethered to the silica gel outer
layer, 1.5–5 µm in diameter.▲▲ (USP 1-Aug-2019) L100—A 55% crosslinked, microporous, hydrophobic resin
core (9-µm microporous particles having a pore size of 10 Å)
Change to read: that consists of a bilayer of anion and cation exchange latex.
The first layer is fully sulfonated latex (140 nm) and the second
L87—Dodecyl silane chemically bonded to porous ▲or layer is fully aminated latex (76 nm).
superficially porous▲ (USP 1-Aug-2019) silica particles, 1.5–10 µm in
diameter. L101—Cholesteryl groups chemically bonded to porous or
nonporous silica or ceramic microparticles, 1.5–10 µm in
L88—Glycopeptide vancomycin linked through multiple diameter, or a monolithic rod.
covalent bonds to 100 Å spherical silica.
L102—1-(3,5-Dinitrobenzamido)-
L89—Packing having the capacity to separate compounds 1,2,3,4-tetrahydrophenanthrene covalently bonded to porous
with a molecular range from 100 to 3000 (as determined by spherical silica particles, 5–10 µm in diameter.
polyethylene oxide), applied to neutral and anionic
water-soluble polymers. A polymethacrylate resin base, L103—A hydroxide-selective, strong anion-exchange resin
cross-linked with polyhydroxylated ether (surface contains consisting of a highly cross-linked core of 7.5-µm porous
some residual cationic functional groups). particles having a pore size of 2000 Å units and consisting of
ethylvinylbenzene cross-linked with 55% divinylbenzene
L90—Amylose tris-[(S)-α-methylbenzyl]carbamate coated on electrostatically bonded with hyperbranched alkanol
porous, spherical silica particles, 3–10 µm in diameter. quaternary ammonium ions.

Change to read: L104—Triazol groups chemically bonded to porous silica

particles, 1.5–10 μm in diameter.
L91—Strong anion-exchange resin consisting of
monodisperse polystyrene/divinylbenzene beads coupled L105—A strong anion-exchange resin consisting of highly
with quartenary amine. Bead size is 3–10 µm.▲▲ (USP 1-Aug-2022) cross-linked 9-µm supermacroporous (2000 Å) particles
functionalized with very low cross-linked latex (0.2%) to
L92—A strong anion-exchange resin consisting of highly provide alkyl quarternary ammonium ion sites.
cross-linked 5- to 9-µm macroporous particles having a
100-Å average pore size and consisting of ethylvinylbenzene Add the following:
cross-linked with 55% divinylbenzene and an anion-exchange
layer grafted to the surface, which is functionalized with ▲
L106
alkanol quarternary ammonium ions. —Weak cation-exchange resin consisting of
ethylvinylbenzene, 55% cross-linked with divinylbenzene
L93—Cellulose tris(3,5-dimethylphenylcarbamate) copolymer, 5–8 µm diameter, macroporous particles having
reversed-phase chiral stationary-phase coated on 3- or 5-µm an average pore size of 100 Å units. Substrate is surface grafted
silica gel particles. with carboxylic acid and phosphonic acid functional groups.
Capacity NLT 2800 µEq/column (4-mm ×
L94—A strong anion-exchange resin consisting of highly 25-cm).▲ (USP 1-Aug-2020)
cross-linked 15-µm microporous particles functionalized with
very low cross-linked latex (0.5%) to provide alkanol L107 (Rosuvastatin Calcium, CHIRALCEL OJ-RH)—Cellulose
quartenary ammonium ion exchange sites. tris(4-methylbenzoate)-coated porous spherical particles, 3–5
µm in diameter, for use with reversed-phase mobile phases.
L95—A highly polar alkyl ligand comprising five hydroxyl [NOTE—A suitable column is Chiralcel OJ-RH from
groups that are chemically bonded to totally porous or www.chiraltech.com.]
superficially porous silica or a monolithic silica rod.
L108—A chiral-recognition protein, cellobiohydrolase (CBH),
L96—Alkyl chain, reversed-phase bonded totally or chemically bonded to silica particles, about 5 µm in diameter.
superficially to porous silica designed to retain hydrophilic and
other polar compounds when using highly aqueous mobile
phase, including 100% aqueous, 1.5–10 µm in diameter.
Printed on: Sat Feb 24 2024, 02:13:32 AM (EST) Printed by: Umesh Kulkarni Published on: 01-Feb-2024 @2024 USPC
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Change to read: Add the following:

L109—Spherical particles of porous graphitic carbon, 1.5– ▲ ▲
L119—Cellulose tris(3,5-dichlorophenylcarbamate),
30▲ (USP 1-Dec-2022) µm in diameter. immobilized on porous, spherical silica particles, 3–5 µm in
diameter.▲ (USP 1-May-2021)
L110—A strong anion-exchange resin consisting of highly
cross-linked 13-µm (less than 10 Å) particles coated with very Add the following:
low cross-linked latex (0.5%) to provide alkanol quaternary
ammonium ion exchange sites. ▲
L120—A hydroxide-selective, strong anion-exchange resin
consisting of a highly cross-linked core of 13-µm microporous
Add the following: particles having a pore size of <10 Angstrom units and
consisting of ethylvinylbenzene cross-linked with 55%
▲
L111—Polyamine chemically bonded to porous, spherical, divinylbenzene with a latex coating composed of 65-nm
silica particles, 5 µm in diameter.▲ 2S (USP41) diameter microbeads (8% cross-linked) with alkanol
quaternary ammonium ions. Capacity NLT 10 µEq/column
L112—A hydroxide-selective, strong anion-exchange resin (4 mm × 5 cm).▲ (USP 1-May-2021)
consisting of a highly cross-linked core of 8.5-µm porous
particles having a pore size of 2000 Å units and consisting of Add the following:
ethylvinylbenzene cross-linked with 55% divinylbenzene
with a latex coating composed of 65-nm diameter microbeads ▲
L121—A hydroxide-selective, strong anion-exchange resin
(5% crosslinked) bonded with alkanol quaternary consisting of a highly cross-linked core of 11-μm porous
ammonium ions. particles having a pore size of less than 10 Å units and
consisting of ethylvinylbenzene cross-linked with 55%
Add the following: divinylbenzene electrostatically bonded with hyperbranched
alkanol quaternary ammonium ions.▲ (USP 1-May-2021)
▲
L113—A hydroxide-selective, strong anion-exchange resin
consisting of a highly cross-linked core of 7.5-µm porous Add the following:
particles having a pore size of 2000 Å units and consisting of
ethylvinylbenzene cross-linked with 55% divinylbenzene ▲
L122
with a latex coating composed of 65-nm diameter microbeads —Sulfobetaine graft-polymerized to totally or superficially
(8% crosslinked) bonded with alkanol quaternary porous hydrophilic polymer particles, 1.0–10 μm in diameter,
ammonium ions.▲ (USP 1-Dec-2019) or a monolithic rod. Packing having densely bonded
zwitterionic groups with 1:1 charge balance.▲ (USP 1-Aug-2021)
Add the following:
Add the following:
▲
L114—Sulfobetaine graft-polymerized to totally or
superficially porous silica, 1.5–10 µm in diameter, or a ▲
L123—Cellulose tris(3-chloro-4-methylphenylcarbamate)
monolithic rod. Packing having densely bonded zwitterionic coated porous silica particles, 3–20 μm in
groups with 1:1 charge balance.▲ (USP 1-Dec-2020) diameter.▲ (USP 1-Dec-2021)

Add the following: Add the following:

▲
L115 (Eptacog Alfa, Dionex CarboPac PA100)— ▲
L124—Strong cation-exchange resin consisting of
Ethylvinylbenzene/divinylbenzene substrate (55% sulfonated cross-linked styrene–divinylbenzene in the silver
cross-linked) agglomerated with quaternary amine form, average 25 μm in diameter.▲ (USP 1-May-2022)
functionalized 275-nm latex microbeads (6% cross-linked),
about 8.5-µm in diameter.▲ (USP 1-Dec-2019) Add the following:

Add the following:

▲
L125—Polyvinyl alcohol polymer gel weak cation-exchange
packing material, 3–7 μm porous particles. The surface is
▲
L116 (Eptacog Alfa, Dionex DNAPac PA100)—Sulfonated polymerized with polybutadiene–maleic acid to provide
ethylvinylbenzene/divinylbenzene substrate approximately carboxylic acid functionalities. The capacity is NLT 1 mEq/
12–14 µm in diameter agglomerated with hydrophilic column.▲ (USP 1-Aug-2022)
quaternary amine functionalized glycidyl-derivative
methacrylate microbeads.▲ (USP 1-Dec-2019) Add the following:

Add the following:

▲
L126
—Amylose tris (3-chlorophenylcarbamate), immobilized on
▲
L117—A crown ether coated on a 5-µm particle size silica gel porous, spherical, silica particles, 1–20 µm in
substrate. The active site is (R)-18-crown- diameter.▲ (USP 1-Aug-2022)
6-ether.▲ (USP 1-Aug-2019)
Add the following:
Add the following: ▲
L127—A crown ether chemically bonded to a 5-µm particle
▲
L118—Aqueous polymerized C18 groups on silica particles, size silica gel substrate. The active site is (S)- pseudo-18-crown-
1.2–5 µm in diameter.▲ (USP 1-Aug-2019) 6-ether.▲ (USP 1-Dec-2022)
Printed on: Sat Feb 24 2024, 02:13:32 AM (EST) Printed by: Umesh Kulkarni Published on: 01-Feb-2024 @2024 USPC
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Add the following: G21—Neopentyl glycol succinate.

▲
L128—Porous particles of polystyrene divinyl benzene with G22—Bis(2-ethylhexyl) phthalate.
linear molecular weight operating range from 200–
2,000,000 g/mol (polystyrene equivalent), 5 μm in G23—Polyethylene glycol adipate.
diameter.▲ (USP 1-Dec-2022)
G24—Diisodecyl phthalate.
Add the following:
G25—Polyethylene glycol compound TPA. A high molecular
▲
L129 A hydroxide-selective, sodium and potassium weight compound of a polyethylene glycol and a diepox ide
complexing resin consisting of a cryptand molecule bonded that is esterified with terephthalic acid.
to 5-µm macroporous particles with an average pore size of [NOTE—Available commercially as Carbowax 20M-TPA
100 Å and consisting of ethylvinylbenzene cross-linked with from suppliers of chromatographic reagents.]
55% divinylbenzene.▲ (USP 1-May-2024)
G26—25% 2-Cyanoethyl-75% methylpolysiloxane.
Add the following:
G27—5% Phenyl-95% methylpolysiloxane.
▲
L130—Cellulose tris(3,5-dimethylphenylcarbamate) coated
on 10-μm silica gel particles.▲ (USP 1-May-2024) G28—25% Phenyl-75% methylpolysiloxane.

G29—3,3′-Thiodipropionitrile.
Phases
G30—Tetraethylene glycol dimethyl ether.
G1—Dimethylpolysiloxane oil.
G31—Nonylphenoxypoly(ethyleneoxy)ethanol (av.
G2—Dimethylpolysiloxane gum. ethyleneoxy chain length is 30); Nonoxynol 30.
G3—50% Phenyl-50% methylpolysiloxane. G32—20% Phenylmethyl-80% dimethylpolysiloxane.
G4—Diethylene glycol succinate polyester. G33—20% Carborane-80% methylsilicone.
G5—3-Cyanopropylpolysiloxane. G34—Diethylene glycol succinate polyester stabilized with
phosphoric acid.
G6—Trifluoropropylmethylpolysiloxane.
G35—A high molecular weight compound of a polyethylene
G7—50% 3-Cyanopropyl-50% phenylmethylsilicone. glycol and a diepoxide that is esterified with
nitroterephthalic acid.
G8—80% Bis(3-cyanopropyl)-20%
3-cyanopropylphenylpoly-siloxane (percentages refer to G36—1% Vinyl-5% phenylmethylpolysiloxane.
molar substitution).
G37—Polyimide.
G9—Methylvinylpolysiloxane.
G38—Phase G1 containing a small percentage of a tailing
G10—Polyamide formed by reacting a C36 dicarboxylic acid inhibitor.
with 1,3-di-4-piperidylpropane and piperidine in the [NOTE—A suitable grade is available commercially as
respective mole ratios of 1.00:0.90:0.20. “SP2100/0.1% Carbowax 1500” from Supelco, Inc.
(www.sigmaaldrich.com/supelco).]
G11—Bis(2-ethylhexyl) sebacate polyester.
G39—Polyethylene glycol (av. mol. wt. about 1500).
G12—Phenyldiethanolamine succinate polyester.
G40—Ethylene glycol adipate.
G13—Sorbitol.
G41—Phenylmethyldimethylsilicone (10%
G14—Polyethylene glycol (av. mol. wt. of 950 to 1050). phenyl-substituted).
G15—Polyethylene glycol (av. mol. wt. of 3000 to 3700). G42—35% phenyl-65% dimethylpolysiloxane (percentages
refer to molar substitution).
G16—Polyethylene glycol compound (av. mol. wt. about
15,000). A high molecular weight compound of polyethylene G43—6% cyanopropylphenyl-94% dimethylpolysiloxane
glycol with a diepoxide linker. [NOTE—Available commercially (percentages refer to molar substitution).
as Polyethylene Glycol Compound 20M, or as Carbowax 20M,
from suppliers of chromatographic reagents.] G44—2% low molecular weight petrolatum hydrocarbon
grease and 1% solution of potassium hydroxide.
G17—75% Phenyl-25% methylpolysiloxane.
G45—Divinylbenzene-ethylene glycol-dimethylacrylate.
G18—Polyalkylene glycol.
G46—14% Cyanopropylphenyl-86% methylpolysiloxane.
G19—25% Phenyl-25% cyanopropyl-50% methylsilicone.
G47—Polyethylene glycol (av. mol. wt. of about 8000).
G20—Polyethylene glycol (av. mol. wt. of 380 to 420).
G48—Highly polar, partially cross-linked cyanopolysiloxane.
Printed on: Sat Feb 24 2024, 02:13:32 AM (EST) Printed by: Umesh Kulkarni Published on: 01-Feb-2024 @2024 USPC
Not official text of the USP-NF. Please refer to the currently official version of the individual Reagent, Solution, or Indicator document for compliance purposes

G49—Dimethylpolysiloxane with chiral building block Add the following:

containing D- or L-valine as chiral agent (for amino acids).
▲
G52—Polyethylene glycol, cross-linked (average molecular
Add the following: weight of NMT 20,000).▲ (USP 1-May-2023)
▲
G50—Base-deactivated Carbowax.▲ (USP 1-Aug-2019) Add the following:

Add the following: ▲

G53—5%-Polyalkylfluorobenzylsiloxane.▲ (USP 1-May-2023)
▲
G51—50% phenyl–50% dimethylpolysiloxane phase, which
is modified with an aromatic selector for optimized separation
of polycyclic aromatic hydrocarbons (PAH).▲ (USP 1-Aug-2019)

Supports
[NOTE—Unless otherwise specified, mesh sizes of 80 to S5—40- to 60-mesh, high-molecular weight
100 or, alternatively, 100 to 120 are intended.] tetrafluorethylene polymer.

S1A—Siliceous earth for gas chromatography has been S6—Styrene-divinylbenzene copolymer having a nominal
flux-calcined by mixing diatomite with Na2CO3 flux and surface area of 250 to 350 m2 per g and an average pore
calcining above 900°. The siliceous earth is acid-washed, then diameter of 0.0091 μm.
water-washed until neutral, but not base-washed. The
siliceous earth may be silanized by treating with an agent such S7—Graphitized carbon having a nominal surface area of
as dimethyldichlorosilane [NOTE—Unless otherwise specified in 12 m2 per g.
the individual monograph, silanized support is intended.] to
mask surface silanol groups. S8—Copolymer of 4-vinyl-pyridine and
styrene-divinylbenzene.
S1AB—The siliceous earth as described above is both acid- and
base-washed. [NOTE—Unless otherwise specified in the S9—A porous polymer based on 2,6-diphenyl-p-phenylene
individual monograph, silanized support is intended.] oxide.

S1C—A support prepared from crushed firebrick and calcined S10—A highly polar cross-linked copolymer of acrylonitrite
or burned with a clay binder above 900° with subsequent and divinylbenzene.
acid-wash. It may be silanized.
S11—Graphitized carbon having a nominal surface area of
S1D—A support prepared from crushed firebrick and 100 m2 per g modified with small amounts of petrolatum and
calcinated or burned with a clay binder above 900°, not acid polyethylene glycol compound.
washed. It may be silanized.
S12—Graphitized carbon having a nominal surface area of
S1NS—The siliceous earth is untreated. 100 m2 per g.

S2—Styrene-divinylbenzene copolymer having a nominal Add the following:

surface area of less than 50 m2 per g and an average pore
diameter of 0.3 to 0.4 μm.
▲
S13—Synthetic sodium crystalline aluminosilicate form of
the X type with pore diameter of approximately 10
S3—Copolymer of ethylvinylbenzene and divinylbenzene Å.▲ (USP 1-May-2023)
having a nominal surface area of 500 to 600 m2 per g and an
average pore diameter of 0.0075 μm.

S4—Styrene-divinylbenzene copolymer with aromatic –O and

–N groups, having a nominal surface area of 400 to 600 m2
per g and an average pore diameter of 0.0076 μm.