JPHD 80 S43
JPHD 80 S43
JPHD 80 S43
ISSN 0022-4006
Keywords Summary
precision medicine; big data; learning health
system; public health dentistry. There has been a call for evidence-based oral healthcare guidelines, to improve
precision dentistry and oral healthcare delivery. The main challenges to this goal
Correspondence
are the current lack of up-to-date evidence, the limited integrative analytical data
Joseph Finkelstein, Department of Population
Health Science and Policy, Icahn School of
sets, and the slow translations to routine care delivery. Overcoming these issues
Medicine at Mount Sinai. New York, requires knowledge discovery pipelines based on big data and health analytics,
NY, USA. intelligent integrative informatics approaches, and learning health systems. This
Tel.: 212-659-9596 article examines how this can be accomplished by utilizing big data. These data
Fax: 212-423-2998 can be gathered from four major streams: patients, clinical data, biological data,
e-mail: joseph.fi[email protected]. and normative data sets. All these must then be uniformly combined for analysis
and modelling and the meaningful findings can be implemented clinically. By
Received: 2/14/2019; accepted 12/2/2019.
executing data capture cycles and integrating the subsequent findings, practi-
doi: 10.1111/jphd.12354 tioners are able to improve public oral health and care delivery.
© 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry. S43
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any
medium, provided the original work is properly cited and is not used for commercial purposes.
Big Data to Promote Precision Oral Health Finkelstein J. et al.
sets, which precludes the possibility of making evidence-based Healthcare System (LHS) paradigm has been introduced to
decisions. The root causes of this problem are manifold. One capitalize on the great potential of high-scale healthcare data
significant problem is that insurance claims in the United combined with patient perspectives into integrated models of
States, which are a major source of data for dental research, continuous care improvement.20
do not have diagnostic codes, but rather treatment codes, A LHS was defined by the Institute of Medicine21 as a
when used for dental insurance.14 The data elements used to system in which “science, informatics, incentives, and cul-
track information in a dental clinic can vary widely from ture are aligned for continuous improvement and innova-
those used for research purposes. A study compared the data tion, with best practices seamlessly embedded in the
elements used by the National Institute of Dental and Cra- delivery process and new knowledge captured as an inte-
niofacial Research’s Cancer Data Standards Registry and the gral by-product of the delivery experience.” A scalable
Dental Information Model, a taxonomy of patient records infrastructure for big data aggregation and analytics pro-
vides necessary framework for personalized health imple-
based on data charting by practicing general dentists. This
mentation in the context of LHS.22 Thus, one potential
study found that only 46% of the data elements based on a
solution to the three challenges outlined above could be
clinical setting overlapped with the data elements used in
the implementation of big data and data science practices
research.15 These obstacles hinder the development of large,
into both the dental research infrastructure and routine
analytical data sets that can be used for research purposes.
clinical oral healthcare.
Improvements in data curation and aggregation in dentistry
The National Institute of Dental and Craniofacial Research
and oral medicine is a necessary step for the integration of has emphasized the importance of evidence-based treatment
precision medicine practices into oral healthcare. An urgent and developed ways to implement data science systematically
need for intelligent and harmonized aggregation of heteroge- through funding, education, and fellowships.9 The translation
neous oral health data sets has been well articulated in sev- of new knowledge discovered by big data analytics into
eral recent publications.4,8 evidence-based dental practice has potential to improve pub-
The third challenge is the slow translation from research to lic oral health outcomes.4 The term “precision public health”
routine care delivery. A survey of clinical dental school faculty has arisen as a descriptor for this approach. Precision public
found that only 47 percent of faculty integrate evidence-based health has been defined as a method to “[improve] the ability
dentistry into their teaching.16 One potential cause for this is to prevent disease, promote health, and reduce health dispar-
that the search for high-quality data is overwhelming and ities in populations by applying emerging methods and
cumbersome, and that clear clinical practice guidelines are technologies for measuring disease, pathogens, exposures,
not available.17 An easily accessible resource, based on up-to- behaviors, and susceptibility in populations; and developing
date evidence could help address this need and improve the policies and targeted implementation programs to improve
implementation of guidelines into clinical practice. Optimal health”.23 This approach requires the usage of big data in
approaches for facilitating translation of research findings order to predict risk profiles, improve our understanding of
into practice have been the subject of broad discussion across the pathogenesis of disease, and develop targeted treatment
all domains of care delivery as reflected by multiple publica- strategies, among other applications.24
tions in the field of dissemination and implementation sci- In this article, we will be discussing the potential role of
ence.18,19 In order to address the challenge of implementing big data in promoting the oral health of the public. The
personalized healthcare into routine practice, the Learning implementation of big data into oral health research and
practice is still a developing process; however, successful
Table 1 Challenges and Solutions Facing the Integration of Precision implementation of big data practices can overcome the chal-
Medicine into Oral Public Health lenges preventing the integration of precision medicine and
Dental
oral health. By addressing these challenges properly, the field
Precision public of oral health can become integrated into the age of precision
Challenge Solution medicine health medicine while also addressing dental public health needs, a
concept we have illustrated in Table 1. Through a scoping
Lack of up-to-date Knowledge discovery X X
evidence-based pipelines based on
review, we will examine the sources of data available for oral
guidelines big data and health health research, its applications for public oral health care
analytics delivery, and current barriers of implementation.
Limited integrative Intelligent integrative X X
analytical data sets informatics
approaches Methods
Slow translation to Learning health X X
Scoping review has been used in this article as a method to
routine care delivery systems
map out the available literature regarding a specific topic
S44 © 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry.
Finkelstein J. et al. Big Data to Promote Precision Oral Health
© 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry. S45
Big Data to Promote Precision Oral Health Finkelstein J. et al.
S46 © 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry.
Finkelstein J. et al. Big Data to Promote Precision Oral Health
Table 3 Primary Data Sources Used from Each Country from a large national health insurance company. Finally, the
Country Primary data sources used study from Korea used data from the Korean National
Health and Nutrition Examination Surveys. This includes a
United States Dental school EHRs
survey of health and nutrition behaviors as well as a physical
Hospital EHRs
Academic data repositories health examination, including an oral health examination.
Insurance claim databases Large EHR data sets were used successfully to generate
Canada Hospital EHRs significant research output on a variety of topics ranging
Finland Public health center EHRs from risk factors for periodontal disease, incidence of rare
Germany Insurance claim databases adverse events, tooth survival curves, predictive data min-
Korea Public health screening
ing for periodontal disease, and outcomes of comprehen-
Taiwan Insurance claims database
sive periodontal treatment. Other areas where EHR data
Public health screening
were used for secondary analysis included edentulism risk
factors, obesity impact on oral cancer outcomes, posterior
restoration outcomes, dental school strategic planning,
20 dental schools that share the common goal to further
quantitative model generation, and outcomes of dental
the field of oral health informatics and improve standard-
preventive visits. A broad range of methodologies was
ized data collection. The third US-based data repository is
employed from simple descriptive statistics to logistic
the DPBRN, which is sponsored by the NIDCR. This
regression, Kaplan–Meier survival analysis, decision tree
research network consists of practicing dentists and aca-
models and various machine-learning approaches.
demics in the field of oral health who have agreed to share
data and conduct research in a collaborative fashion. The
fourth paper describing the development of a data reposi- Future directions
tory was based in Sweden and presented the Swedish
Despite successful use of existing data sets for big data
Quality Registry for Caries and Periodontal Diseases
analytics, many articles emphasized limitations of their
(SKaPa). In contrast to the data repositories being devel-
data sets and need for more comprehensive integrated
oped in the United States, which were primarily based on
framework for big data allowing simultaneous inclusion of
collecting data from academic institutions, SKaPa was
multiple basic science, clinical and social science domains
developed as a registry for both private and public dental
related to oral health. Existing data repositories such as
clinics in Sweden.
SKaPa, National Dental Practice-Based Research Network,
BigMouth were instrumental in building useful predictive
Predictive analytics for knowledge discovery
models but lacked generalizability due to the limitations of
Of the data sources used for predictive analytics and the patient populations (dental school data, Medicaid data,
knowledge discovery in the studies that were based in the insurance data) included in these databases. However,
United States, the most common was EHR data from dental these repositories provided useful and valuable initial
schools, which was used in four of the seven studies included information for implementing precision dental public
in this review. Other data sources used were the Nationwide health strategies. A number of articles utilized big data
Emergency Department Sample, which is a national database generated by social media to characterize oral health in
of emergency department visits, the BigMouth data reposi- diverse patient population and to generate tailored messag-
tory described above, and Medicaid claims data. Studies ing promoting oral health guidelines. Overall, a consensus
based in countries outside of the United States used data framework for future directions of big data for precision
from a variety of sources. A Canadian study queried the oral health evolved from these articles that comprised a
Canadian Hospitals Injury Reporting and Prevention Pro- vision of synergistic and harmonized aggregation of multi-
gram, which is a hospital-based database of injury and poi- ple heterogeneous data sets pertinent to oral health and
soning events. Two studies based in Finland both used EHR dental care delivery from sequencing data, proteomics,
data from community health centers. A study in Taiwan metabolomics, to EHR data, exposome, and social media
used data from the National Health Insurance research data- and environmental data. Future directions using Big Data
base, which is a database of claims data from Taiwan’s man- were identified in articles describing generation of
datory single-payer insurance program. The other study supporting materials for evidence-based dentistry, tailored
from Taiwan used data from the Taiwanese Nationwide Oral healthcare guideline sharing via social media, development
Screening Program, a public health initiative to screen adults of common data elements for sharing clinical and
in Taiwan who have risk factors for oral cancer. These research data at point of care, and innovative approaches
patients were then linked to data from Taiwan’s National for identifying and targeting population subgroups for
Death Registry. A study in Germany also used claims data preventive care.
© 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry. S47
Big Data to Promote Precision Oral Health Finkelstein J. et al.
S48 © 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry.
Finkelstein J. et al. Big Data to Promote Precision Oral Health
order to provide an even more detailed analysis of tooth brus- (NGS) data has led to the development of data repositories
hing technique.57,58 Currently, the implementation of this data for oral microbiome genomics. Repositories such as the
collection method is still in its relative infancy. As these types of Human Oral Microbiome database and the Human Micro-
technology develop and gain widespread adoption, these data biome Consortium have emerged as data aggregate to provide
can be analyzed to provide immediate feedback to patients. In standardized and easily accessible sources of oral microbiome
addition, potential exists for these data to be documented and genomic and taxonomic data to researchers and clinicians
uploaded into a central data repository to provide new avenues alike.63,64 Genome-wide association studies have also been
of research. performed on traditionally at-risk populations such as US
Our scoping review identified the development of major Hispanics and children to further identify characteristics that
data repositories aimed at collecting comprehensive dental can be used to stratify these patients.65,66 However, the rela-
data as another important trend in oral health research. As tionship between genetics and caries risk is still unclear. Cur-
we demonstrated in Results section, in the United States rently, these studies have only found modest associations
three major initiatives have emerged in recent years as between gene variants and caries risk. A large number of
forerunners for the big data trend in oral health. The larg- databases describing genes, proteins, and other biological fac-
est academic initiative is the Consortium for Oral Health- tors currently exist in order to facilitate research regarding
Related Informatics (COHRI), a consortium of members the biological mechanisms of disease.67 Conducting more
from over 20 dental schools aiming at standardizing oral NGS experiments to find links between biological factors and
health data collection and improving informatics utiliza- oral disease can improve integration of oral health pathways
tion in dental education, health care, and research.29 The into these databases and allow bioinformatics research in this
second data repository, BigMouth, was developed out of field to become more accessible.68
this consortium. The BigMouth data repository established Finally, the generation of data from normative data sets
the technical foundation and developed a data governance such as large clinical trials and national public health sur-
framework for secondary analysis of electronic dental veys represent another important source of data for oral
records including patient demographics, diagnoses, medi- health research at the population level. The randomized
cal history, dental history, procedures, odontogram, peri- clinical trial has long been recognized as the gold standard
odontal chart and treatment provider information.27 The for clinical investigational research. The data collected
third US-based data repository is the Dental Practice- from clinical trials have been pivotal in clarifying the effi-
Based Research Network (DPBRN), which is sponsored by cacy of many therapeutic agents used for caries and peri-
the NIDCR. This research network consists of practicing odontal disease control. In addition, data from clinical
dentists and academics in the field of oral health who have trials can be analyzed to find a variety of secondary out-
agreed to share data and conduct research in a collabora- comes. For example, the X-ACT clinical trial for xylitol
tive fashion.28 Outside of these data repositories that have lozenge therapy in adults found that xylitol supplementa-
been specially developed for academic purposes, clinical tion did not produce a statistically significant effect on car-
data can also come from a wide range of other sources. ies reduction.69 Beyond this primary finding, baseline data
Data from Medicaid claims, private insurance claims, collected from this clinical trial were analyzed to determine
emergency department records, and many other primary risk factors for root caries.70 However, in recent years
data sources have been used in oral health data analysis clinical trials in the field of oral health have come under
studies across the globe.33,37,43 Recent studies identified some scrutiny for their low adherence to best reporting
potential limitations of using EHR data generated solely by practices71. Prospective registration of clinical trials is nec-
dental schools as they may represent a biased patient sam- essary to promote study fidelity and data sharing. Unfortu-
ple.59 Similarly, administrative and claims records such as nately, some studies of dental clinical trials have found
Medicaid data represent a very valuable resource use of that only around 24–25 percent of clinical trials in the
which requires understanding of its strengths and limita- fields of dentistry and orthodontics are prospectively regis-
tions.60 Future research should capitalize on growing avail- tered.72,73 Because of this, the volume of normative data
ability of integrated comprehensive data sets representing sets available for public oral health research is lacking in
all facets of oral health.4 some regards. Improved adherence to clinical trial registra-
With the rise of the disciplines of the OMICS (genomics, tion and reporting guidelines and promotion of wide data
proteomics, metabolomics, etc.), biological data from in vitro sharing can facilitate the data analysis pipeline for oral
and in vivo sampling has also entered the age of big data. health research.74
Genomic sequencing of the oral microbiome has already hel- Social media platforms are another source of useful data
ped identify novel strains of cariogenic bacteria to improve for oral care delivery. In Japan, researchers set out to deter-
our understanding of the pathogenesis of caries.61,62 The mine if social networks among older adults impacted the
accelerating rate of production of next generation sequencing determinants of oral health. They found that the extent of
© 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry. S49
Big Data to Promote Precision Oral Health Finkelstein J. et al.
Figure 2 Illustration of knowledge discovery pipeline using electronic data. PCA: principal component analysis; PheWAS: phenome-wide association
study; GWAS: genome-wide association study; CART: classification and regression trees; SVM: support vector machine; NN: neural network; RF:ran-
dom forest.
edentulism in older adults is negatively correlated with the Science and Informatics (OHDSI) framework.77 In the
number of social networks.75 Another study looked at bully- educational domain, research on utilizing multiple data
ing on Twitter related to dentofacial features and orthodontic streams to better monitor student performance and iden-
treatment. They identified cases of bullying, qualified them, tify areas for personalized improvement will promote per-
and looked for coping mechanisms the victims and their fam- sonalized education and individualized student support
ilies had for the mistreatment.76 These studies demonstrate tailored to individualized performance profile. In Figure 2
the value of data gleaned from social media. Data gathered below, we illustrate an example of how electronic data can
from social media demonstrates that researchers can measure be used to facilitate knowledge discovery and eventually
the positive or negative impact of psychosocial variables on predictive modeling. Electronic phenotyping allows precise
oral health. The data present vast opportunities for tailored identification of specific oral health conditions and syn-
interventions both by clinicians and public healthcare dromes in the presence of data gaps and ambiguity of large
professionals. heterogeneous oral health data. Care pathways visualiza-
tion and analytics provides temporal representation of oral
healthcare delivery process. Sequential pattern mining
How to use data
identifies characteristic trajectories of dental conditions
Using the four major data streams discussed above, big and allows automated identification of patient subgroups
data provide four analytic domains that can be combined not readily discernible form a manual chart review. Elec-
to deliver optimal precision oral health. In the clinical tronic phenotyping results can be correlated with treat-
domain, multiple research opportunities exist to study pre- ments or medications used in the delivery of care in order
cision dental care delivery tailored to specific patient pro- to provide a holistic picture of each patient. Data mining
files. Development of real-time decision support tools for or other analysis techniques can then be applied to these
individualized diagnosis and treatment planning based on data to discover new patterns or associations and to iden-
a multitude of relevant factors provided before, during and tify optimal personalized treatment pathways. Finally, pre-
after the dental encounter will significantly improve the dictive models of outcomes and ideal treatments can be
quality of dental care and patient satisfaction. In the socio- established based on individual patient characteristics.
behavioral domain, identifying oral health risk factors spe- Similar analytical workflow can be applied to identify opti-
cific to particular population subgroups and delivering mal precision health pathways both for individual patients
targeted preventative interventions using digital media will as well as for unique patient subgroups such as elderly.
greatly facilitate individualized oral health on a population The development of clinical decision support systems
level. In the translational science domain, research on how (CDS) could greatly improve integration of evidence-based
the wired digital operatories access and utilize data from dentistry into clinical practice. A recent survey of dental clini-
outside streams, including a patient’s genetic traits and cians found that most providers were amenable to the idea of
microbiome to facilitate personalized care delivery will be implementing CDS into their daily practice and saw potential
supported by Common Data Models and cross-linked bio- for improving quality of care, patient oral health, and other
medical ontologies such as the Observational Health Data similar benefits.78 These tools can give providers summaries
S50 © 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry.
Finkelstein J. et al. Big Data to Promote Precision Oral Health
of current evidence for every step of their decision-making Basic science data can be integrated into the clinician
process based on analysis of digitally entered patient informa- workspace so that biomarkers predicting disease risk and
tion or integration with patient EHR.79 Development and therapy outcomes can be identified for optimal treatment
integration of these tools into routine clinical care is still in planning. The integration of oral microbiome data and
progress. A CDS developed in New York provides dental genetic testing into clinical decision making can improve
hygienists with assessments and recommendations for diagnostic precision and the risk stratification process. The
screening of chronic, systemic conditions such as hyperten- principle of “deep phenotyping” can also be applied to
sion and diabetes.80 As vital signs such as blood pressure are improve our understanding of disease staging and out-
measured and recorded, the CDS provides assessments of comes. Deep phenotyping refers to “the precise and com-
personalized disease risk and prompts for referral to a special- prehensive analysis of phenotypic abnormalities in which
ist in appropriate situations as established by the current the individual components of the phenotype are observed
hypertension management guidelines.81 Another CDS was and described” in order to facilitate a more comprehensive
developed by Machado et al. for use in dental trauma man- understanding of the pathologic basis of disease.93 A study
agement and was found to improve adherence to evidence- on oral microbial profiles used principal components anal-
based guidelines in both dental students as well as experi- ysis to determine the microbial profile of healthy patients
enced pediatric dentists.82 The use of CDS for tobacco abuse when compared to chronic and aggressive periodontitis
screening and interventions has been found to improve both patients.94 Deep phenotyping of periodontitis patients can
provider adherence to current evidence and patient provide new insights into pathologic phenotypic character-
outcomes.83,84 istics that are predictive of tooth loss.95 Similar principles
Data mining techniques have high potential for improv- can also be applied to implant patients in order to develop
ing our understanding of particular socio-behavioral risk more comprehensive risk profiles of patients likely to
factors for oral disease. These techniques can be applied to develop implant failure or peri-implantitis.96 As we briefly
populations that are already considered at-risk in order to described earlier, there is currently lack of systematic evi-
identify individual risk factors that can be addressed using dence to support the use of genotyping in clinical dental
targeted public health interventions. This strategy is particu- practice.97 However, as patient genotyping becomes more
larly useful in the field of oral health because the develop- widespread and our understanding of the role of genomics
ment of caries and periodontal disease can be chronic and in oral health increases, there may be a role in the future
insidious in onset, leading to diagnosis in late stages of dis- for genetics to become another dimension for clinicians to
ease. Yoon et al. used big data and deep learning algorithms stratify patients.68
on a large sample of Latino patients to identify demo- Finally, data analysis can be implemented in the educa-
graphic, behavioral, and psychological factors associated tional domain in order to improve clinician training for future
with tooth mobility85 and other indicators of oral health sta- performance. The application of big data analytics in the area
tus in older adults.86 Other studies utilized big data in order of dental education spans from improving student training at
to develop risk prediction profiles for development of peri- dental schools to continuous professional improvement
odontal disease,34,38 implant failure,87 peri-implantitis,88 and and to ongoing real-time support via EHR at the point of
alveolar osteitis.89 Using big EHR data, Boehm A et al. care. Recent studies demonstrated potential of big data in
uncovered patient determinants of care utilization compli- predicting academic outcomes and professional performance
ance in a student dental clinic.90 In addition to risk predic- in graduate students.98,99 This approach was shown to
tion of oral disease, research in this field can be used to find have implications for optimizing personalized learning and
novel associations between oral health behavior and sys- improving student assessments based on individualized feed-
temic health. For example, a study conducted in 2018 found back provided in a timely fashion.100 Additionally, use of real
that regular dental visits were independently associated with life examples drawn from dental EHR in the process of dental
lower stroke risk.91 Similar studies can be used to further education demonstrated promising results in predoctoral39
integrate the fields of medicine and dentistry in order to and postdoctoral training.101,102 As evidence-based dentist
improve the overall health of the patient. Once individual training is being considered as an essential means for improve-
risk factors have been identified, preventive interventions ments in the quality of patients care,103 data analytics workflows
can be developed in order to increase patient awareness of for ongoing reporting of dental care quality metrics and pro-
these risk factors, change health behavior, and improve viding instructive feedback to dental professionals will be
patient outcomes. An example of this is the My Smile increasingly used in the context of LHS. Implementation of
Buddy iPad application, which engages families of at-risk point of care CDS based on individual patient profile and
populations to identify health behavior that puts their chil- driven by big data analytics has been shown to be an addi-
dren at risk of caries development and encourages them to tional vehicle for delivering best clinical practices and
improve their oral health habits.92 supporting ongoing clinician education.104
© 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry. S51
Big Data to Promote Precision Oral Health Finkelstein J. et al.
While social media can provide valuable data, social Three major challenges
marketing is a powerful tool for the promotion of health
messages, ones that can target and reduce oral health dis- A lack of up-to-date evidence-based guidelines has been
parities to subpopulations by changing attitudes, increasing previously noted in the literature.113 This paucity of
knowledge, and impacting behavior.105 The Mighty Mouth evidence-based practices can be corrected by employing
oral health program, which positions oral health as essen- knowledge discovery pipelines revealed through big data
tial to overall health, is a great example of a program that analytics and predictive modeling. Knowledge discovered
embraces social marketing. It emphasizes the immediate in multiple interconnected databases allows extract useful,
rewards of good oral health, such as fresher breath, and nontrivial, and valid patterns from large heterogeneous
frames oral health as easy, important, and cost-effective. It data sets,114 avoiding the “garbage in garbage out” risk
is presented as fun and informative, rather than demand- presented by the large quantities of data available. Broadly,
ing more scientific and informational approach. With big this pipeline may entail the following steps: electronic
data, oral healthcare providers can develop effective social phenotyping!care pathways visualization!sequential
marketing programs to tailor the message and improve pattern mining and predictive models. Electronic
care delivery. Social media can serve as a powerful source phenotyping is essential for big data research using EHRs.
of patient-generated data for big data analytics as well as This concept is based on the notion that every disease and
effective media for targeted messaging for oral health syndrome has a unique digital signature that can be used
promotion.106 to automatically identified cases in EHR even in the pres-
As of the July 2017, Hispanics in the United States ence of erroneous or insufficient coding. This is well illus-
accounted for 18.1 percent of the total population.107 They trated by a dry socket signature in EHR. When a patient is
face major general health and, more specifically, oral diagnosed with a dry socket, they must have had an extrac-
health inequities. More than half of Hispanics over the age tion first, then returned within a set number of days with
of 64 will suffer from tooth decay and they are more likely pain, open socket, or missing blood clot,59,89 with or with-
to experience delays in accessing dental care. There has out other possible symptoms. Even without the proper
been a widespread call by the greater dental community to code for a dry socket, we still have an electronic signature
address the oral health needs of this population.108 His- of this event in the record and possible accompanying side
panic Dental Association convened a workshop of health effects as well. Electronic phenotyping can be learned by
care providers and other experts to examine the current utilizing data science and classifying the exclusive signa-
state of Hispanic oral health research and identify gaps in tures of conditions, adverse events, and procedures. An
existing data and research methods. Research and develop- analytical system can read past what is stated in the note,
ment priorities were outlined by this workshop to better and with high sensitivity and specificity, recognize the clas-
meet the oral healthcare needs of Hispanic patients and to ses of the encounter, creating care pathway visualizations.
implement standardized, validated instruments using a The next step is employing sequential pattern mining, to
comprehensive data collection infrastructure.109 Another ultimately build precise predictive models. Overall, this
disadvantaged population whose oral healthcare needs approach can continue knowledge discovery and a quality
require urgent attention are older adults.110 In a recent improvement cycle.
article using cross-sectional analyses of the British Implementing these concepts requires verified, integrative,
Regional Heart Study (BRHS) and the Health, Aging, and and harmonized data sets, designing intelligent integrative
Body Composition (HABC) Study,111 markers of poor oral information architecture to manage these data. The systems
health were associated with disability and poor physical are integrative because they utilize multiple heterogeneous
function in older populations. The authors proposed fur- data sets from basic science, electronic medical records,
ther prospective investigations of these associations and patients, environments, and so on. It is insufficient to simply
underlying pathways. These research initiatives require an merge silos into one data set. It is required that there be an
increase in population-based studies, social and behavioral understanding of what the data are and how they are interre-
sciences, health promotion and communications, gene– lated; in that sense, the data sets must be intelligent. Data sets
environment interactions, and research training and work- can only know about selves if the system includes meta-data
force development. Broad inclusion of minority that explains what is in the data set and what are relationships
populations and other disadvantaged populations in big between internal and external data elements. The underlying
data initiatives was identified as a crucial component of systems will understand these relationships using cross-linked
addressing oral health inequities.112 By utilizing big data biomedical ontologies that will facilitate comprehensive
and precision oral health, public health professionals can knowledge discovery in a harmonized systematic way.
promote oral health in minority communities and attempt This process of learning and intervening has already
to reduce these disparities. begun, utilizing social media. An innovative example of
S52 © 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry.
Finkelstein J. et al. Big Data to Promote Precision Oral Health
using big data analytics for targeted public health interven- a cyclical process and once it reaches its action potential, it
tions was recently demonstrated by a team at Columbia will be a self-perpetuating system when it is implemented
University that developed a system that identifies in the context of LHS. It is a cycle of: capturing data
foodborne illnesses in NYC restaurants by analyzing Yelp actively and passively!organizing data into actionable
reviews.115 The system utilizes logistic regression trained information!analyzing outcomes!learning new proto-
with bias-adjusted augmented data, which has identified cols, and cycling back to the first step. From the patient’s
10 outbreaks and 8,253 complaints of foodborne illness perspective, the process has begun before the patient has
associated with NYC restaurants since 2012. Perhaps the even set foot into the office. In Figure 3, we illustrate the
best description of necessary pieces of a learning health care self-perpetuating cycle of precision medicine principles
system was given by Dr. Friedman, who chairs the Depart- into oral healthcare.
ment of Learning Health Sciences at the University of We can potentially use the data to identify a patient’s
Michigan School of Medicine in Ann Harbor. He outlines preferences and recognize moments when s/he can be
five major points that have been frequently repeated116: delivered messaging tailored to their individual oral health
1. One can learn from every patient’s characteristics needs. During the patient’s clinic visit, there is decision
and experiences. support, risk assessment, vital sign monitoring, pain reduc-
2. Best practice knowledge is immediately available to tion, resiliency support, oral health education, health
support decisions. screening, and survey completion. In the clinic, the deci-
3. Improvement is continuous through ongoing study. sion support can be provided based on personalized algo-
4. An infrastructure enables this to happen routinely rithm analytics that can identify similar patients and
and with economy of scale. understand which procedures were most effective for this
5. All of this is part of the culture. group of patients and suggest these treatments at the point
There is a slow progress in implementing these five of delivery. Post-visit, the process repeats itself, while con-
major tenets of LHS into dental care.113 The major prereq- tinually updating the intelligent integrative databases that
uisite of successful introduction of sustainable LHS ecosys- will then be able to help this individual and others in the
tem in dental care is establishment of comprehensive future. Overall, this environment would promote precision
integrated intelligent big data infrastructure combining oral health and allow us to build powerful predictive
multiple heterogeneous data streams related to oral health. models and hopefully improve dental care delivery and
This is both a challenge to and impetus for the implemen- patient outcomes. This strategy would allow the provider
tation of precision oral healthcare. Precision oral health is to better employ different translational projects that also
© 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry. S53
Big Data to Promote Precision Oral Health Finkelstein J. et al.
identify underlying pathophysiological determinants of oral 3. Gillette J, Matthews JD, Frantsve-Hawley J, Weyant RJ.
health. Through the cyclical nature of learning healthcare The benefits of evidence-based dentistry for the private
systems, dentists will have the potential for feedback rapidly, dental office. Dent Clin N Am. 2009;53(1):33–45. https://
even in real time to guide care-related decisions. doi.org/10.1016/j.cden.2008.09.002.
We must acknowledge the big data limitations origi- 4. Slavkin HC. From high definition precision healthcare to
nated from dental EHR in developing a precision oral precision public oral health: opportunities and challenges.
health system. One of which is our current approach to J Public Health Dent. 2018. https://doi.org/10.1111/jphd.
oral health documentation and data capture. The inherent 12296.
5. Joda T, Waltimo T, Pauli-Magnus C, Probst-Hensch N,
limitation to EHR and other records is their purpose to
Zitzmann NU. Population-based linkage of big data in
document the encounter, for communication between pro-
dental research. Int J Environ Res Public Health. 2018 Oct
viders, and as a legal document.117,118 The primary focus
25;15(11):1–5.
of clinical documentation is not research but continuity of
6. Nanayakkara S, Zhou X, Spallek H. Impact of big data on
guideline-concordant patient care. EHR limitations may
oral health outcomes. Oral Dis. 2019 Jul;25(5):1245–52.
lead to miscoded, under-coded, or other issues with docu- https://doi.org/10.1111/odi.13007.
mentation of signs and symptoms. These deficiencies can 7. Meyer SL. Toward precision public health. J Public Health
be partially overcome by the electronic phenotyping as Dent. 2019. https://doi.org/10.1111/jphd.12315.
previously discussed, but cannot be totally overcome with- 8. Joda T, Waltimo T, Probst-Hensch N, Pauli-Magnus C,
out implementing next generation of intelligent EHR. Zitzmann NU. Health data in dentistry: an attempt to
master the digital challenge. Public Health Genomics. 2019;
22(1–2):1–7. https://doi.org/10.1159/000501643.
Conclusion 9. Kusiak J, Somerman M. Data science at the National
Institute of Dental and Craniofacial Research. J Am Dent
The new definition of oral health promulgated by the World Assoc. 2016;147(8):597–9. https://doi.org/10.1016/j.adaj.
Dental Federation119 supports a comprehensive vision that 2016.06.005.
reflects multifaceted interaction between physiological, social, 10. Stohler C. Editorial: the next frontier: digital disease
and psychological attributes of dental care that are germane for detection in cyberspace. J Oral Facial Pain Headache.
the quality of life. Intelligent integrative infrastructure for big 2014;28(2):105. https://doi.org/10.11607/ofph.2014.2.e.
oral health data will provide a foundational framework for 11. Stohler C. Editorial: orofacial pain and the prospects of
implementing this vision into reality. Following major tenets of precision medicine. J Oral Facial Pain Headache. 2015;29
a learning healthcare system, big data will be increasingly used (4):321.
to support delivery of precision oral health by determining the 12. Smiley CJ, Tracy SL, Abt E, Michalowicz BS, John MT,
best care every time and with each care experience with contin- Gunsolley J. Systematic review and meta-analysis on the
uous knowledge discovery. This approach will translate hetero- nonsurgical treatment of chronic periodontitis by means
geneous big data into a cycle of care improvement while of scaling and root planing with or without adjuncts. Br
identifying gaps in care, advancing quality, and improving Dent J. 2015;219(5):215–5. https://doi.org/10.1038/sj.bdj.
patient satisfaction and safety. Ultimately, ever-expanding evi- 2015.684.
dence will support personalized patient-centered care, optimal 13. Canadian Agency for Drugs and Technologies in Health.
wellness, individualized decision support, and targeted thera- Dental scaling and root planing for periodontal health: a
pies. It can promote creative thinking, dental education and review of the clinical effectiveness, cost-effectiveness, and
innovation for care delivery and reimbursement models, lead- guidelines. Ottawa, ON: Canadian Agency for Drugs and
ing to vast improvements in public’s oral health. Technologies in Health; 2016.
14. Beil H, Preisser JS, Rozier RG. Accuracy of record linkage
software in merging dental administrative data sets.
J Public Health Dent. 2012;73(2):89–93. https://doi.org/10.
References 1111/j.1752-7325.2012.00343.x.
1. Dzau V, Ginsburg G, Chopra A, Goldman D, Green E, 15. Liu K, Acharya A, Alai S, Schleyer T. Using electronic
Leonard D, Mcclellan M, Plump A, Terry S, Yamamoto K. dental record data for research. J Dent Res. 2013;92(7):
Realizing the full potential of precision medicine in health S90–6. https://doi.org/10.1177/0022034513487560.
and health care: a vital direction for health and health 16. Marshall TA, Straub-Morarend CL, Qian F,
care. NAM Persp. 2016;6(9):1–13. https://doi.org/10.31478/ Finkelstein MW. Perceptions and practices of dental
201609k. school faculty regarding evidence-based dentistry. J Dent
2. Weyant RJ. Evidence-based dentistry: the foundation for Educ. 2013;77(2):146–51.
modern dental practice. Dent Clin North Am. 2019;63(1): 17. Afrashtehfar KI, Mansour KA. From dental science to
ix–x. https://doi.org/10.1016/j.cden.2018.09.001. clinical practice: knowledge translation and evidence-based
S54 © 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry.
Finkelstein J. et al. Big Data to Promote Precision Oral Health
dentistry principles. Saudi Dental J. 2017;29(3):83–92. Network. J Dent. 2013 Nov;41(11):1051–9. https://doi.org/
https://doi.org/10.1016/j.sdentj.2017.02.002. 10.1016/j.jdent.2013.04.002.
18. Newlands R, Duncan EM, Prior M, Elouafkaoui P, 29. Stark PC, Kalenderian E, White JM, Waliji MF,
Elders A, Young L, Clarkson JE, Ramsay CR. Translation Stewart DCL, Kimmes N. Consortium for Oral health-
research in a dental setting (TRiaDS) research related informatics: improving dental research, education,
methodology group. Barriers and facilitators of evidence- and treatment. J Dent Educ. 2010;74(10):1051–65.
based management of patients with bacterial infections 30. Rao DP, McFaull S. Tooth ’aches’: injuries related to
among general dental practitioners: a theory-informed toothbrush use. Paediatr Child Health. 2019;24(1):e40–4.
interview study. Implement Sci. 2016;11(11):1–12. https:// https://doi.org/10.1093/pch/pxy073 Epub 2018 May 31.
doi.org/10.1186/s13012-016-0372-z. 31. Suni J, Vähänikkilä H, Päkkilä J, Tjäderhane L, Larmas M.
19. Meursinge Reynders R, Ronchi L, Ladu L, Di Girolamo N, Review of 36,537 patient records for tooth health and
de Lange J, Roberts N, Mickan S. Barriers and facilitators longevity of dental restorations. Caries Res. 2013;47(4):
to the implementation of orthodontic mini-implants in 309–17. https://doi.org/10.1159/000346691.
clinical practice: a protocol for a systematic review and 32. Käkilehto T, Salo S, Larmas M. Data mining of clinical
meta-analysis. Syst Rev. 2016;5(5):22. https://doi.org/10. oral health documents for analysis of the longevity of
1186/s13643-016-0198-4. different restorative materials in Finland. Int J Med
20. Budrionis A, Bellika JG. The learning healthcare system: Inform. 2009 Dec;78(12):e68–74. https://doi.org/10.1016/j.
where are we now? A systematic review. J Biomed Inform. ijmedinf.2009.04.004.
2016;64:87–92. https://doi.org/10.1016/j.jbi.2016.09.018 33. Raedel M, Hartmann A, Bohm S, Priess HW, Samietz S,
Epub 2016 Sep 28. Konstantinidis I, Walter MH. Four-year outcomes of
21. Engineering a Learning Healthcare System. A look at the restored posterior tooth surfaces—a massive data analysis.
future: workshop summary. Washington, DC: The National Clin Oral Investig. 2017;21(9):2819–25. https://doi.org/10.
Academies Press; 2011. https://doi.org/10.17226/12213. 1007/s00784-017-2084-4.
22. Mandl KD, Kohane IS, McFadden D, Weber GM, 34. Lee JH, Jeong SN, Choi SH. Predictive data mining for
Natter M, Mandel J, Schneeweiss S, Weiler S, Klann JG, diagnosing periodontal disease: the Korea National Health
Bickel J, Adams WG, Ge Y, Zhou X, Perkins J, Marsolo K, and nutrition examination surveys (KNHANES V and VI)
Bernstam E, Showalter J, Quarshie A, Ofili E, Hripcsak G, from 2010 to 2015. J Public Health Dent. 2018;79(1):
Murphy SN. Scalable collaborative infrastructure for a 44–52. https://doi.org/10.1111/jphd.12293.
learning healthcare system (SCILHS): architecture. J Am 35. Chan C, You H, Lian H, Huan C. Patients receiving
Med Inform Assoc. 2014 Jul-Aug;21(4):615–20. https://doi. comprehensive periodontal treatment have better clinical
org/10.1136/amiajnl-2014-002727. outcomes than patients receiving conventional periodontal
23. Khoury MJ, Galea S. Will precision medicine improve treatment. J Formos Med Assoc. 2016;115:152e162. https://
population health? JAMA. 2016;316(13):1357–8. https:// doi.org/10.1016/j.jfma.2015.10.017.
doi.org/10.1001/jama.2016.12260. 36. Su WW, Su CW, Chang DC, Chuang SL, Chen SL,
24. Dolley S. Big Data’s role in precision public health. Front Hsu CY, Yen AM, Chiu SY, Fann JC, Lee YH, Jeng YC,
Public Health. 2018;6:68. https://doi.org/10.3389/fpubh. Lee YC, Chiu HM, Chen TH, Wang CP, Chen MK.
2018.00068. Impact of varying anatomic sites on advanced stage and
25. Levac D, Colquhoun H, O’Brien KK. Scoping studies: survival of oral cancer: 9-year prospective cohort of 27 717
advancing the methodology. Implement Sci. 2010 Sep 20;5: cases. Head Neck. 2019 May;41(5):1475–83. https://doi.
69. https://doi.org/10.1186/1748-5908-5-69. org/10.1002/hed.25579.
26. von Bültzingslöwen I, Östholm H, Gahnberg L, Ericson D, 37. Nalliah RP, Da Silva JD, Allareddy V. The characteristics
Wennström JL, Paulander J. Swedish quality registry for of hospital emergency department visits made by people
caries and periodontal diseases - a framework for quality with mental health conditions who had dental problems.
development in dentistry. Int Dent J. 2019 Oct;69(5): J Am Dent Assoc. 2013;144(6):617–24.
361–8. https://doi.org/10.1111/idj.12481. 38. Thyvalikakath TP, Padman R, Vyawahare K, Darade P,
27. Walji MF, Kalenderian E, Stark PC, White JM, Paranjape R. Utilizing dental electronic health records data
Kookal KK, Phan D, Tran D, Bernstam EV, Ramoni R. to predict risk for periodontal disease. Stud Health Technol
BigMouth: a multi-institutional dental data repository. Inform. 2015;216:1081.
J Am Med Inform Assoc. 2014;21(6):1136–40. https://doi. 39. Rai NK, Carey C, Brunson D, Tiwari T. Increasing dental
org/10.1136/amiajnl-2013-002230. students’ understanding of population surveillance
28. Gilbert GH, Williams OD, Korelitz JJ, Fellows JL, through data mining. J Dent Educ. 2019 Mar;83(3):281–6.
Gordan VV, Makhija SK, Meyerowitz C, Oates TW, https://doi.org/10.21815/JDE.019.031.
Rindal DB, Benjamin PL, Foy PJ, National Dental PBRN 40. Filker PJ, Cook N, Kodish-Stav J. Electronic health
collaborative group. Purpose, structure, and function of records: a valuable tool for dental school strategic
the United States National Dental Practice-Based Research planning. J Dent Educ. 2013 May;77(5):591–7.
© 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry. S55
Big Data to Promote Precision Oral Health Finkelstein J. et al.
41. Boland MR, Hripcsak G, Albers DJ, Wei Y, Wilcox AB, 56. McKenzie KW, Pretty IA. Connected toothbrushes:
Wei J, Li J, Lin S, Breene M, Myers R, Zimmerman J, bridging the gap to personalized oral health. Am J Dent.
Papapanou PN, Weng C. Discovering medical conditions 2018;31(3):115–20.
associated with periodontitis using linked electronic health 57. Rooban T, Vernon L, Kumar PM, Mohandoss A, Walls T.
records. J Clin Periodontol. 2013 May;40(5):474–82. Using smartphone video “selfies” to monitor change in
https://doi.org/10.1111/jcpe.12086. toothbrushing behavior after a brief intervention: a pilot
42. Kalenderian E, Tokede B, Ramoni R, Khan M, Kimmes N, study. Indian J Dent Res. 2016;27(3):268–77. https://doi.
White J, Vaderhobli R, Yansane A, Feilzer A, Walji M. org/10.4103/0970-9290.186241.
Dental clinical research: an illustration of the value of 58. Inada E, Saitoh I, Yu Y, Tomiyama D, Murakami D,
standardized diagnostic terms. J Public Health Dent. 2016; Takemoto Y, Morizono K, Iwasaki T, Iwase Y,
76(2):152–6. https://doi.org/10.1111/jphd.12124. Yamasaki Y. Quantitative evaluation of toothbrush and
43. Tiwari T, Rai N, Brow A, Tranby EP, Boynes SG. arm-joint motion during tooth brushing. Clin Oral
Association between medical well-child visits and dental Investig. 2014;19(6):1451–62. https://doi.org/10.1007/
preventive visits: a big data report. JDR Clin Trans Res. s00784-014-1367-2.
2019 Jul;4(3):239–45. 59. Levitin SA, Grbic JT, Finkelstein J. Completeness of
44. Huber J, Woods T, Fushi A, Duong MT, Eidelman AS, electronic dental Records in a student clinic: retrospective
Zalal AR, Urquhart O, Colangelo E, Quinn S, Carrasco- analysis. JMIR Med Inform. 2019 Mar 21;7(1):e13008.
Labra A. Social media research strategy to understand 60. Riley GF. Administrative and claims records as sources of
clinician and public perception of health care messages. health care cost data. Med Care. 2009 Jul;47(7 Suppl 1):
JDR Clin Trans Res. 2019. https://doi.org/10.1177/ S51–5. https://doi.org/10.1097/MLR.0b013e31819c95aa.
2380084419849439. 61. Huang X, Palmer SR, Ahn S-J, Richards VP, Williams ML,
45. Helmi M, Spinella MK, Seymour B. Community water Nascimento MM, Burne RA. A highly Arginolytic
fluoridation online: an analysis of the digital media streptococcus species that potently antagonizes
ecosystem. J Public Health Dent. 2018;78(4):296–305. Streptococcus mutans. Appl Environ Microbiol. 2016;82(7):
https://doi.org/10.1111/jphd.12268. 2187–201. https://doi.org/10.1128/aem.03887-15.
46. Liu K, Acharya A, Alai S, Schleyer TK. Using electronic 62. Camelo-Castillo A, Benitez-Paez A, Belda-Ferre P,
dental record data for research: a data-mapping study. Cabrera-Rubio R, Mira A. Streptococcus dentisani sp. nov.,
J Dent Res. 2013;92(7 Suppl):90S–6S. a novel member of the mitis group. Int J Syst Evol
47. Shah T, Rabhi FA, Ray PK. Investigating an ontology- Microbiol. 2014;64(Pt 3):1073–3. https://doi.org/10.1099/
based approach for big data analysis of inter-dependent ijs.0.062802-0.
medical and oral health conditions. Cluster Comput. 63. Chen T, Yu W-H, Izard J, Baranova OV, Lakshmanan A,
2014;18:351–67. https://doi.org/10.1007/s10586-014- Dewhirst FE. The human oral microbiome database: a web
0406-8. accessible resource for investigating oral microbe
48. Shetty V, Yamamoto J, Yale K. Re-architecting oral taxonomic and genomic information. Database (Oxford).
healthcare for the 21st century. J Dent. 2018;74(Suppl 1): 2010;2010:1–10. https://doi.org/10.1093/database/baq013.
S10–4. https://doi.org/10.1016/j.jdent.2018.04.017. 64. Gevers D, Knight R, Petrosino JF, Huang K, McGuire AL,
49. Polverini PJ, Krebsbach PH. Research and discovery Birren BW, Nelson KE, White O, Methé BA,
science and the future of dental education and practice. Huttenhower C. The human microbiome project: a
J Dent Educ. 2017;81(9):eS97–eS107. https://doi.org/10. community resource for the healthy human microbiome.
21815/JDE.017.040. PLoS Biol. 2012;10(8):e1001377. https://doi.org/10.1371/
50. Lee CH, Yoon H-J. Medical big data: promise and journal.pbio.1001377.
challenges. Kidney Res Clin Pract. 2017;36(1):3–11. 65. Morrison J, Laurie CC, Marazita ML, Sanders AE,
51. Glick M. Taking a byte out of big data. J Am Dent Assoc. Offenbacher S, Salazar CR. Genome-wide association
2015 Nov;146(11):793–4. study of dental caries in the Hispanic communities health
52. Murdoch TB, Detsky AS. The inevitable application of big study/study of Latinos (HCHS/SOL). Hum Mol Genet.
data to health care. JAMA. 2013;309(13):1351–2. https:// 2016;25(4):807–16.
doi.org/10.1001/jama.2013.393. 66. Haworth S, Shungin D, van der Tas JT, Vucic S, Medina-
53. Yu X-T, Zeng T. Integrative analysis of Omics big data. Gomez C, Yakimov V. Consortium-based genome-wide
Methods Mol Biol. 2018;1754:109–35. https://doi.org/10. meta-analysis for childhood dental caries traits. Hum Mol
1007/978-1-4939-7717-8_7. Genet. 2018;27(17):3113–27.
54. O’Connor PJ. Normative data: their definition, 67. Zou D, Ma L, Yu J, Zhang Z. Biological databases for
interpretation, and importance for primary care human research. Genomics Proteomics Bioinformatics.
physicians. Fam Med. 1990;22(4):307–11. 2015;13(1):55–63.
55. Raghupathi W, Raghupathi V. Big data analytics in healthcare: 68. Zhang F, Finkelstein J. The relationship between single
promise and potential. Health Inf Sci Syst. 2014;2(1):3. nucleotide polymorphisms and dental implant loss: a
S56 © 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry.
Finkelstein J. et al. Big Data to Promote Precision Oral Health
scoping review. Clin Cosmet Investig Dent. 2019;11: 8) guidelines and the outpatient management of
131–41. https://doi.org/10.2147/CCIDE.S207445. hypertension in the African-American population. N
69. Bader JD, Vollmer WM, Shugars DA, Gilbert GH, Am J Med Sci. 2015;7(10):438–45. https://doi.org/10.4103/
Amaechi BT, Brown JP, Laws RL, Funkhouser KA, 1947-2714.168669.
Makhija SK, Ritter AV, Leo MC. Results from the xylitol 82. Machado JP, Lam XT, Chen J-W. Use of a clinical
for adult caries trial (X-ACT). J Am Dent Assoc. 2013;144 decision support tool for the management of traumatic
(1):21–30. https://doi.org/10.14219/jada.archive.2013.0010. dental injuries in the primary dentition by novice and
70. Ritter AV, Preisser JS, Chung Y, Bader JD, Shugars DA, expert clinicians. Dent Traumatol. 2018;34(2):120–8.
Amaechi BT, Makhija SK, Funkhouser KA, Vollmer WM, https://doi.org/10.1111/edt.12390.
X-ACT Collaborative Research Group. Risk indicators for 83. Montini T, Schenkel AB, Shelley DR. Feasibility of a
the presence and extent of root caries among caries-active computerized clinical decision support system for treating
adults enrolled in the xylitol for adult caries trial (X-ACT). tobacco use in dental clinics. J Dent Educ. 2013;77(4):
Clin Oral Investig. 2011;16(6):1647–57. https://doi.org/10. 458–62.
1007/s00784-011-0656-2. 84. Rindal DB, Rush WA, Schleyer TK, Kirshner M,
71. Giannobile W. Improving clinical trials in dentistry. J Dent Boyle RG, Thoele MJ, Asche SE, Thyvalikakath T,
Res. 2015;94(3):6S–7S. https://doi.org/10.1177/ Spallek H, Durand EC, Enstad CJ, Huntley CL. Computer-
0022034515569308. assisted guidance for dental office tobacco-cessation
72. Papageorgiou SN, Antonoglou GN, Sándor GK, Eliades T. counseling. Am J Prev Med. 2013;44(3):260–4. https://doi.
Randomized clinical trials in orthodontics are rarely org/10.1016/j.amepre.2012.10.023.
registered a priori and often published late or not at all. 85. Yoon S, Odlum M, Lee Y, Choi T, Khronish IM,
Plos One. 2017;12(8):e0182785. https://doi.org/10.1371/ Davidson KW, Finkelstein J. Applying deep learning to
journal.pone.0182785. understand predictors of tooth mobility among urban
73. Smaïl-Faugeron V, Fron-Chabouis H, Durieux P. Clinical latinos. Stud Health Technol Inform. 2018;251:241–4.
trial registration in oral health journals. J Dent Res. 2014; 86. Yoon S, Choi T, Odlum M, Mitchell DA, Kronish IM,
94(3):8S–13S. https://doi.org/10.1177/0022034514552492. Davidson KW, Finkelstein J. Machine learning to
74. Institute of Medicine. Sharing clinical research data: identify behavioral determinants of oral health in inner
workshop summary. Washington, DC: The National city older hispanic adults. Stud Health Technol Inform.
Academies Press; 2013. https://doi.org/10.17226/18267. 2018;251:253–6.
75. Aida J, Kondo K, Yamamoto T, Saito M, Ito K, Suzuki K, 87. Hickin MP, Shariff JA, Jennette PJ, Finkelstein J,
Osaka K, Kawachi I. Is social network diversity associated with Papapanou PN. Incidence and determinants of dental
tooth loss among older Japanese adults? PLOS ONE. 2016;11 implant failure: a review of electronic health records in a
(7):e0159970. https://doi.org/10.1371/journal.pone.0159970. U.S. dental school. J Dent Educ. 2017;81(10):1233–42.
76. Chan A, Antoun J, Morgaine K, Farella M. Accounts of 88. Kordbacheh Changi K, Finkelstein J, Papapanou PN. Peri-
bullying on twitter in relation to dentofacial features and implantitis prevalence, incidence rate, and risk factors: a
orthodontic treatment. J Oral Rehabil. 2017;44(4):244–50. study of electronic health records at a U.S. dental school.
https://doi.org/10.1111/joor.12487. Clin Oral Implants Res. 2019 Apr;30(4):306–14. https://
77. Hripcsak G, Duke JD, Shah NH, Reich CG, Huser V, doi.org/10.1111/clr.13416 Epub 2019 Mar 10.
Schuemie MJ. Observational health data sciences and 89. Levitin SA, Jeong IC, Finkelstein J. Mining electronic
informatics (OHDSI): opportunities for observational dental records to identify dry socket risk factors. Stud
researchers. Stud Health Technol Inform. 2015;216:574–8. Health Technol Inform. 2019 Jul 4;262:328–31.
78. Mertz E, Bolarinwa O, Wides C, Gregorich S, Simmons K, 90. Boehm A, Jeong IC, Finkelstein J, Whalen S, Graham R.
Vaderhobli R, White J. Provider attitudes toward the Using big data to uncover patient determinants of care
implementation of clinical decision support tools in dental utilization compliance in a student dental clinic. Stud
practice. J Evid Based Dent Pract. 2015;15(4):152–63. Health Technol Inform. 2019 Jul 4;262:324–7.
https://doi.org/10.1016/j.jebdp.2015.09.001. 91. Sen S, Giamberardino LD, Moss K, Morelli T,
79. Mendonca E. Clinical decision support systems: Rosamond WD, Gottesman RF, Beck J, Offenbacher S.
perspectives in dentistry. J Dent Educ. 2004;68(6):589–97. Periodontal disease, regular dental care use, and incident
80. Russell SL, Greenblatt AP, Gomes D, Birenz S, ischemic stroke. Stroke. 2018;49(2):355–62. https://doi.org/
Golembeski CA, Shelley D, McGuirk M, Eisenberg E, 10.1161/strokeaha.117.018990.
Northridge ME. Toward implementing primary care 92. Chinn CH, Levine J, Matos S, Findley S, Edelstein BL. An
at chairside: developing a clinical decision support system Interprofessional collaborative approach in the
for dental hygienists. J Evid Based Dent Pract. 2015;15(4): development of a caries risk assessment mobile tablet
145–51. https://doi.org/10.1016/j.jebdp.2015.08.003. application: my smile buddy. J Health Care Poor
81. Abel N, Contino K, Jain N, Grewal N, Grand E, Hagans I, Underserved. 2013;24(3):1010–20. https://doi.org/10.1353/
Hunter K, Roy S. Eighth joint National Committee (JNC- hpu.2013.0114.
© 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry. S57
Big Data to Promote Precision Oral Health Finkelstein J. et al.
93. Robinson PN. Deep phenotyping for precision medicine. 108. Han C. Oral health disparities: racial, language and
Hum Mut. 2012;33(5):777–80. https://doi.org/10.1002/ nativity effects. SSM Popul Health. 2019;8:100436. https://
humu.22080. doi.org/10.1016/j.ssmph.2019.100436.
94. Feres M, Louzoun Y, Haber S, Faveri M, Figueiredo LC, 109. Ramos-Gomez F, Cruz GD, Watson MR, Canto MT,
Levin L. Support vector machine-based differentiation Boneta AE. Latino oral health: a research agenda toward
between aggressive and chronic periodontitis using eliminating oral health disparities. J Am Dent Assoc. 2005;
microbial profiles. Int Dent J. 2017;68(1):39–46. https:// 136(9):1231–40.
doi.org/10.1111/idj.12326. 110. Razak PA, Richard KMJ, Thankachan RP, Hafiz KAA,
95. Morelli T, Moss KL, Preisser JS, Beck JD, Divaris K, Wu D, Kumar KN, Sameer KM. Geriatric oral health: a review
Offenbacher S. Periodontal profile classes predict periodontal article. J Int Oral Health. 2014;6(6):110–6.
disease progression and tooth loss. J Periodontol. 2018;89(2): 111. Kotronia E, Wannamethee SG, Papacosta AO,
148–56. https://doi.org/10.1002/jper.17-0427. Whincup PH, Lennon LT, Visser M, Weyant RJ,
96. Papantonopoulos G, Gogos C, Housos E, Bountis T, Harris TB, Ramsay SE. Oral health, disability and physical
Loos BG. Prediction of individual implant bone levels and function: results from studies of older people in the United
the existence of implant “phenotypes”. Clin Oral Implants Kingdom and United States of America. J Am Med Dir
Res. 2016;28(7):823–32. https://doi.org/10.1111/clr.12887. Assoc. 2019;20(12):1654.e1-1654.e9. https://doi.org/10.
97. Kornman K, Polverini P. Clinical application of genetics to 1016/j.jamda.2019.06.010.
guide prevention and treatment of oral diseases. Clin 112. Gansky SA, Shafik S. At the crossroads of oral health
Genet. 2014;86(1):44–9. https://doi.org/10.1111/cge.12396. inequities and precision public health. J Public Health
98. Adam J, Bore M, Childs R, Dunn J, Mckendree J, Dent. 2019. https://doi.org/10.1111/jphd.12316.
Munro D, Powis D. Predictors of professional behaviour 113. Spallek H, Song M, Polk D, Bekhuis T, Frantsve-Hawley J,
and academic outcomes in a UK medical school: a Aravamudhan K. Barriers to implementing evidence-based
longitudinal cohort study. Med Teach. 2015;37(9):868–80. clinical guidelines: a survey of early adopters. J Evid Based
99. Niessen AS, Meijer RR, Tendeiro JN. Predicting Dent Pract. 2010;10(4):195–206. https://doi.org/10.1016/j.
performance in higher education using proximal jebdp.2010.05.013.
predictors. PLoS One. 2016 Apr 13;11(4):e0153663. 114. Domingo-Ferrer J, Kriegel H, Schubert M, Embley D, Li X.
100. Bill Cope B, Kalantzis M. Big data comes to school: KDD pipeline. Encyclopedia of Database Systems. 2009;2009:
implications for learning, assessment, and research. AERA 1586–7. https://doi.org/10.1007/978-0-387-39940-9_1134.
Open. 2016 April-June;2(2):1–19. https://doi.org/10.1177/ 115. Effland T, Lawson A, Balter S, Devinney K, Reddy V,
2332858416641907. Waechter H, Gravano L, Hsu D. Discovering foodborne
101. Schleyer TK, Corby P, Gregg AL. A preliminary analysis of the illness in online restaurant reviews. J Am Med Inform Assoc.
dental informatics literature. Adv Dent Res. 2003 Dec;17:20–4. 2018;25(12):1586–92. https://doi.org/10.1093/jamia/ocx093.
102. Song M, Liu K, Abromitis R, Schleyer TL. Reusing 116. Friedman CP, Allee NJ, Delaney BC, Flynn AJ,
electronic patient data for dental clinical research: a review Silverstein JC, Sullivan K, Young KA. The science of
of current status. J Dent. 2013 Dec;41(12):1148–63. learning health systems: foundations for a new journal.
103. Weyant RJ. Teaching evidence-based practice: Learn Health Syst. 2016;1(1):e10020.
considerations for dental education. Dent Clin North Am. 117. Ho Y, Gadd C, Kohorst K, Rosenbloom S. A qualitative
2019 Jan;63(1):97–117. analysis evaluating the purposes and practices of clinical
104. Gordon SM, Camargo GA, Mejia GC, Sutherland JN. Use documentation. Appl Clin Inform. 2014;5(1):153–68.
of the dental electronic health record for research: https://doi.org/10.4338/ACI-2013-10-RA-0081.
assessing demographic and oral health characteristics data 118. Mangalmurti S, Murtagh L, Mello M. Medical malpractice
for clinic patients. J Dent Educ. 2018 Dec;82(12):1249–57. liability in the age of electronic health records. Surv Anesthesiol.
105. Brocklehurst P, Morris P, Tickle M. Social marketing: an 2011;55(6):317–9. https://doi.org/10.1097/sa.0b013e3182379506.
appropriate strategy to reduce oral health inequalities? Int 119. Glick M, Williams DM, Kleinman DV, Vujicic M,
J Health Promot Educ. 2012;50(2):81-91–1. https://doi.org/ Watt RG, Weyant RJ. A new definition for oral health
10.1080/14635240.2012.661969. developed by the FDI World Dental Federation opens the
106. Lin K, Finkelstein J. Patient empowerment in online door to a universal definition of oral health. J Public
support group for temporomandibular disorder. Proc of Health Dent. 2017 Dec;77(1):3–5.
the 2017 IEEE International Conference on Bioinformatics
and Biomedicine (BIBM). 2017;2017:1569–74. https://doi.
How to cite this article: Finkelstein J, Zhang F, Levitin SA,
org/10.1109/BIBM.2017.8217897.
Cappelli D. Using big data to promote precision oral health in
107. Hispanic Heritage Month 2018. Census.gov.https://www.
census.gov/newsroom/facts-for-features/2018/hispanic- the context of a learning healthcare system. Journal of Public
heritage-month.html. Published September 2018. Accessed Health Dentistry. 2020;80:S43–S58. https://doi.org/10.1111/
January 1, 2019. jphd.12354
S58 © 2020 The Authors. Journal of Public Health Dentistry published by Wiley Periodicals, Inc. on behalf of American Association of Public Health Dentistry.