Pharmacokinetics Questions

QUESTIONS
Pharmacokinetics
1) Pharmacokinetics is
a) Study of biological and therapeutice ect of the drug
b) Study of mechanisms of drug action
c) study of Methods of new drugdevelopment
d) Study of absorption, distribution, biotransformationand excreation of dug
2) The reasons determining Bioavailability

a) Rheological parameters of blood
b) Amount of substance obtainedorally and and quantity of drug intake
c) Extent of absorption and hepatic firstpass metabolism
d) Granular filtiration rate
3) Most of drugs are distributed homogeneously

a) True
b) Falce
4) What does pharmacokinetics include?

a) Compilcations of drug therapy
b) Influence of drug in metabolismprocess
c) Influence of drug on gens
d) Drug biotransformation in organs
5) What kind of substances can not permeate the cell membrane by passive di usion
a) Lipid soliable
b) Non-ionized substance
c) Hydrophilic
d) Hydrophobic
‫تم تجميع اﻻسئلة بواسطة فريق اﻷفق الطبي‬

QUESTIONS
6) Hydrophilic medical agents has one of the following properties

a) Low ability to penetrate through the cell membrane
b) Penetrate the membrane through endocytosis
c) Easy permeation through the Blood brain-parrier
d) High reabsorption in renal tubules
7) Estimulation of liver microsomal enzymes

a) Require dose increse of some drugs
b) Require dose decrease in some drugs
c) Prolong duration of action
d) Intensify the unwanted reaction of the drug
8) Pick out the right statement

a) Microsomal oxidation always result in inactivation of a compound
b) Microsomal oxidation always result in decrease of compound toxcisty
c) Microsomal oxidation always result in increase water soliabilty
d) Microsomal oxidation always result in increase lipid soliability thus its excreation
9) Biotransformation of drug is to render them

a) Less ionized form
b) Less lipid soliable
c) More pharmacological active form
d) More lipid soliable
10) The term "Biotransformation" include the following

a) Accumulation of a substance in a fat tissue
b) Binding to plasma protein
c) Process of physicochemical and biochemical alternation of drug in the body
d) Accumulation of a substance in a tissue
11) A small amount of volium of distribution(Vd)is common for lipophylic

substance,easy penetrating barriers and widely distributed in plasma
a) True
b) Falce

QUESTIONS
12) For calculation od (Vd) one muat take into account

a) Concentration of substance in plasma
b) Concentration of substance in urine
c) Daily dose of drug
d) Therapeutical width of drug action
13) The volume of distribution (vd) relates Anonymous Quiz

a) Single to a daily dose of an administrated drug
b) An administered dose to body weight
c) Amount of drug in the body to plasma concentration of drug
d) Unchanged drug reach the systemic circulation
14) The e ect of the body on the drugmeans...........

a) Pharmacology
b) Pharmacodynamic
c) Pharmacokinetic
d) All of above
15) The pharmacokinetic includes ..........

a) Absorption - distribution
b) Distribution - action of drug
c) Metabolism - e ect of drug
d) Biotransformation(metabolism)- excretion
e) A and D
16) It is the transportation of the drug across the biological membranes ...........
a) Absorption
b) Adsorption
c) Distribution
d) Excretion

QUESTIONS
17) The passive and active transport, pinocytosis, Facilitated di usion are
mechanisms of ..........
a) Absorption
b) Distribution
c) Biotransformation
d) Excretion
18) The practical and molecular size have a .......... relationship with the absorption of
drug.
a) Positive
b) Inverse
c) Negative
d) B and C
19) The increasing of ........... follow by .......... In absorption of drug.

a) Water solubility - increasing
b) Libid solubility - increasing
c) Water solubility - decreasing
d) Libid solubility - decreasing
e) B and C
20) The relationship between the absorption and the ionisation is a/an .........
relationship.
a) Positive
b) Negative
c) Inverse
d) B and C
21) The relationship between the absorption and the blood flow at site of application is
a/an ........... relationship.
a) Positive
b) Negative
c) Inverse
d) B and C

QUESTIONS
22) The relationship between the absorption and the area of absorption is a/an
.........relationship.
a) Positive
b) Negative
c) Inverse
d) B and C
23) If we increase the acidity of medium for weak acid drug, the unionized form of drug
molecule will .........
a) Increase
b) Decrease
c) Non of above
24) If we increase the acidity of medium for weak acid drug, the absorption rate
will..........
a) Increase
b) Decrease
c) Non of above
25) If we decrease the (PH) of medium forweak acid drug, the unionized form of drug
molecule will .........
a) Increase
b) Decrease
c) Non of above
26) If we decrease the (PH) of medium for weak acid drug, the absorption rate will
..........
a) Increase
b) Decrease
c) Non of above
27) Alkalinization of the urine......... the excretion on......... drugs.

QUESTIONS
a) Increase - alkaline
b) Decrease - acidic
c) Increase- acidic
d) A and C
28) Alkalinization of the urine ......... the excretion on ........ drugs.

c) Decrease - alkaline
d) A and B
29) Acidification of the urine.......... the excretion on ......... drugs.

b) Decrease - alkaline
c) Increase - acidic
d) B and C
30) Acidification of the urine ......... the excretion on........ drugs.
a) Increase - acidic
c) Decrease - alkaline
d) A and C
31) The toxicity with aspirin can be treated by...........Of urine, because it is a/an ........
drug.
a) Acidification - alkaline
b) Acidification - acidic
c) Alkalinization - alkaline

QUESTIONS
32) The toxicity with aspirin can be treated by........... Of urine, because it is a/an
.….....drug.
a) Acidification - alkaline
b) Acidification - acidic
c) Alkalinization - alkaline
d) Alkalinization - acidic
33) It is the fraction (f) of unchanged drug that reaches the systemic circulation
following administration by any route .........
a) Absorption
b) Biotransformation
c) Bioavailability
d) First pass metabolism
34) It is the chemical changes (metabolism) that a ect drugs before reaching the
systemic circulation .........
a) Absorption
b) Adsorption
c) Bioavailability
d) First pass metabolism
35) If we have 100 mg of a dose are administered orally and 70 mg of this drug are
absorbed unchanged, the.......... will be 30%
a) Bioavailability
b) First pass metabolism
c) F
d) A and C
36) If we have 100 mg of a dose are administered orally and 70 mg of this drug are
absorbed unchanged, the.......... will be 70%
a) Bioavailability
b) First pass metabolism
c) F
d) A and C

QUESTIONS
37) The bioavailability or (F) = ........

a) (AUC injected/ AUC oral) ÷ 100
b) (AUC injected/ AUC oral) x 100
c) (AUC oral/ AUC injected)÷ 100
d) (AUC oral/ AUC injected) x 100
188 answers
38) The most common site of metabolism is the .........

i) Kidney
ii) Heart
iii) Liver
iv) Stomach
39) It is the process by which a drug moves freely between body compartment..........
a) Absorption
b) Distribution
c) Excretion
d) Metabolism
40) There is a ......... Correlation between the di usion rate of the drug and the
distribution rate.
a) Positive
b) Negative
c) Inverse
d) B,C
41) There is a positive correlation between the.......... and the distribution of drugs.
a) Blood flow
b) Perfusion rate
c) Di usion
d) All of above

QUESTIONS
42) All of the following have a high perfusion rate except.........

a) Kidney
b) Liver
c) Bone
d) Heart
e) Brain
43) All of the following have a low perfusion rate except .........
a) Skin
b) Bone
c) (resting) skeletal muscle
d) Liver
44) The most important protein that binds the drugs in blood is .......... for most the
drugs.
a) Globiolins
b) Albumins
c) Fibrinogen
d) Regulatory protein
45) The acidic drugs like (salicylates)are bound to ..........

a) Globiolins
b) Albumin
c) Alpha-1 acid glycoproteins
d) Alpha-2 acid glycoproteins
46) The basic drugs like (streptomycin) are bound to all of following except .........
a) Alpha-1 acid glycoproteins
b) Alpha-2 acid glycoproteins
c) Albumins
d) Globiolins
e) Alpha lipoproteins
f) Beta lipoproteins

QUESTIONS
47) It is the apparent volume that would be required to contain the entire drug in the
body at the same concentration as in plasma ...........
a) Volume of distribution
b) Vd
c) Apparent volume distribution
d) All of above
48) The human body is a homogeneous compartment.

i) True
ii) False
49) The amount of the drug in the body / plasma concentration =

a) Vd
b) Co
c) CL
d) T1/2
50) The hemodialysis is not e ective in treatment of drug toxicity, if we have a.........
a) Small Vd
b) Medium Vd
c) Large Vd
d) B and C
51) In the large Vd the half-life of drug is a short period.

a) True
b) False
52) It is the time required for the plasma concentration to fall to one half its original
values ..........
a) CL
b) Half life
c) (T1/2)

QUESTIONS
d) B and C
53) The time required reaching Css, or time of drug elimination, usually after ........
a) 3-4 t1/2
b) 4-5 t1/2
c) 5/6 t1/2
d) A or B
54) The elimination half-life is (negatively) proportional with the........, And (positively)
proportional with ........
a) Vd - Clearance
b) Clearance - Va
55) It is the plasma concentration at which the rate of drug administration equals the
rate of elimination (rate in = rate out)..........
a) CL
b) CsS
c) Steady state concentration
d) B and C
56) It is the dose that can raise the plasma concentration to the target concentration
rapidly ........
a) Vd
b) Tc
c) LD
d) Css
57) The plasma concentration of the drug that required achieving the therapeutic
e ect.........
a) Vd
b) LD
c) Tc
d) Target concentration

QUESTIONS
e) C and D
58) What is the loading dose required for drug

a) 80 mg
b) 800 mg
c) 0.008 mg
d) 8 mg
59) Css ...........

a) Tc
b) MD
c) CL
d) Maintenance Dose
e) B and D
60) ....... Is the target average steady statedrug concentration.

a) Tc
b) Lc
c) Css
d) CpSSav
61) What maintenance Dose is required for drug A if; target average SS concentration is
10 mg/L; CL of drug A is 0.020 L/kg/hr; patients weight 100 kg?
a) 480
b) 530
c) 640
62) What maintenance Dose is required for Drug A if; target average SS concentration
Is 10 mg/L; CL of drug A is 0.020 L/kg/hr; Patients weight 100 kg?
a) 480
b) 530
c) 640
d) 700

QUESTIONS
63) It is the general term for chemical Transformations that occur to drugs inside The
body ……….
a) Metabolism
b) Bioavailability
c) Biotransformation
d) A and C
64) The water soluble drugs are more easily to Excreted.

a) True
b) False
65) Drugs that are …….. Are generally Excreted unchanged by the kidney.
a) Water soluble
b) Lipid soluble
c) Both of them
d) Neither of them
66) In the (most) drugs, the conversion of a Pharmacologically from……….. to………

i) Active – active
ii) Inactive – inactive
iii) Inactive – active
iv) Active – inactive
67) The codeine changed to morphine is an Example of conversion of a
Pharmacologically from ………. To……….
i) Active – inactive
ii) Inactive – active
iii) Inactive – inactive
iv) Active – active
68) The enalapril converted to enalaprilat is an Example of conversion of a

Pharmacologically from……….to……….
ii) Active – inactive

QUESTIONS

iv) Inactive – inactive
69) The diazepam changed to oxazepam is an Example of conversion of a

Pharmacologically from …….. to …….
ii) Active – inactive
iv) Inactive – inactive
70) The active drug is named a prodrug.

i) True
ii) False
71) The most important organ of Biotransformation is the ………

i) Heart
ii) Kidney
iii) Liver
iv) Stomach
72) The number and variability of the Biotransformation enzymes are the highest In the
………
a) Heart
b) Kidney
c) Liver
d) Stomach
73) The lungs is not a site of Biotransformation.

a) True
b) false
74) The placenta and skin are sites of Biotransformation.
a) True
b) False

QUESTIONS
75) The sulphate conjugation is an (important) Example of ……….. biotransformation.

a) Lungs
b) Liver
c) Kidney
d) Stomach
76) The MAO is an (important) example Of ………. Biotransformation.

i) Lungs
ii) Heart
iii) Liver
iv) Stomach
77) All of following are Phase 1 of biotransformation except…….

i) Oxidation
ii) Reduction
iii) Conjugation
iv) Hydrolysis
v) The Oxidation, Reduction, Hydrolysis
78) Are………. Of biotransformation.

i) Phase I
ii) Phase Il
iii) Phase III
iv) Phase IV
79) The microsomal P450 enzymes areLocated at stomach microsomes.
i) True
ii) False
80) The microsomal P450 enzymes show high A inity to high ……… Molecules.
a) Hydrophilic
b) Lipophilic
c) Lipophobic
d) A and B

QUESTIONS
81) The majority of drugs are metabolized by The microsomal enzymes that located in
The liver.
a) True
b) False
82) The microsomal enzymes are just located In the liver.

a) True
b) False
83) The Ethanol is inactivated by alcohol Dehydrogenase, Succinylcholine by plasma

Pseudocholinesterase, 6-mercaptopurine By xanthine and epinephrine by
Monoamine oxidase.., are examples Of ………
a) Microsomal enzymes
b) Non-Microsomal enzymes
c) The first 2 is a microsomal and latest 2 Is Non-Microsomal
d) The first 2 is a Non-Microsomal and Latest 2 is microsomal
84) The drugs that stimulate the enzymes that Inhibit themselves called……….
a) Biochemical tolerance
b) Non-competitive drug
c) Competitive drug
d) Microsomal drug
85) The erythromycin, ketokonazole, Cimetidine are an example of ………

a) Inducers enzyme
b) Inhibitors enzyme
86) All of following are examples of inducers Enzyme except……..

a) Phenobarbital
b) Cimetidine
c) Rifambicin
d) Carbamazepine

QUESTIONS
87) The individuals who have atypicalmCholinesterase (hydrolysis of Succinylcholine)

is an example of ……….
a) B and C
b) Induction microsomal enzymes
c) Inhibiting microsomal enzymes
d) Genetic di erences
88) In newborns cytochrome P450 enzymes And glucuronoyl transferases are

Su icient.
True
False
89) Reduction in enzyme activity is higher in Old females.

a) True
b) False
90) The First pass elimination are a ected by Age.

a) True
b) False
91) The Succinylcholine and other choline Esters and procaine do not change with
Change in gender.
a) true
b) false
92) The Succinylcholine and other choline Esters and procaine are inactivated faster In
……..
a) Men
b) Womens

QUESTIONS
93) In the liver diseases the e ect and adverse E ects are ………
i) Increase
ii) Decrease
94) The transformation of pro-drugs into their Active forms occurs …….. In liver
diseases.
i) More
ii) Less

QUESTIONS
Excretion
1. Irreversible removal of drug from the body By all routs ……….
Absorption
Distribution
Biotransformation
Excretion (elimination)
2. The drug excretion has one way.
True
False
3. The volume of plasma cleared from the Drug per unit time (ml/min) means ……..
Clearance
Total body clearance
Renal clearance
Glomerular filtration
4. The plasma volume cleared from the drug Per unit time via the elimination of the
drugFrom all biotransformation and excretion Mechanism in the body means ……..
Clearance
Renal clearance
Tubular secretion

QUESTIONS
5. The volume of plasma cleared from the Non-metabolized (unchanged) drug via the
Excretion by kidneys per minute, Means………
Clearance
Renal clearance
Tubular reabsorption
6. (Glomerular filtration + tubular secretion)- Tubular reabsorption =
Clearance
Renal clearance
All of above
7. Volume of urine x plasma concentration of Drug/ urine concentration of drug =
Clearance
Renal clearance
Non of above
8. The plasma protein binding of the drug Don’t a ect the Renal clearance.
True
False
9. Elimination of most follows……….
First-order kinetics

QUESTIONS
Zero-order kinetics
Second-order kinetics
Non of above
10. Where a constant (amount) of drug is Eliminated per unit of time, it is Called……….
Zero-order kinetics
A and B
11. Where a constant (fraction) of drug in the Body is eliminated per unit of time, it is
Called ………..
Zero-order kinetics
A and C
12. The process is directly proportional to drug Concentration, ……….
Zero-order kinetics
Just A and C
13. The process takes place at a constant rate Independent of drug

concentration,………

QUESTIONS
Zero-order kinetics
CL
14. The Zero-order kinetics is a linear process.
True
False
15. The First-order kinetics has no constant Half-life.
True
False
16. Any saturable process are examples of Zero-order kinetics.
True
False

QUESTIONS
Adverse drug reaction

17. It is defined as any response to a drug Which is harmful and unintended and Which
occurs at normal therapeutic Dose………….
Side e ect
Adverse drug reaction
Reaction of drug
18. The type of adverse drug reaction that is Associated with long-term drug therapy Is
…………
Augmented pharmacological e ect (A)
Bizzare (abnormal) e ect (B)
Chronic e ect ©
Delayed e ect (D)
End-of-treatment e ect €
19. The type of adverse drug reaction that unpredictable, uncommon, usually not
Related to the pharmacological actions of The drug is ……….
Chronic e ect ©
Delayed e ect (D)
20. The type of adverse drug reaction that Refer to carcinogenic and teratogenic
E ects is ………..

QUESTIONS
Chronic e ect ©
Delayed e ect (D)
21. The type of adverse drug reaction that Sudden withdrawal e ects is ……….
Chronic e ect ©
Delayed e ect (D)
22. The type of adverse drug reaction that Predictable, common and related to
Pharmacological action of the drug, and it Is (dose) dependent is ……….
Chronic e ect ©
Delayed e ect (D)
23. Cushing syndrome due corticosteroids is An example of which type of adverse drug
Reaction …………
Chronic e ect ©
Delayed e ect (D)

QUESTIONS
24. Anaphylaxis due to penicillin is an example Of which type of adverse drug

Reaction……….
Chronic e ect ©
Delayed e ect (D)
25. Benzodiazepine dependence is an example Of which type of adverse drug

Reaction………
Chronic e ect ©
Delayed e ect (D)
26. Bone marrow depression of Chloramphenicol is an example of which Type of

adverse drug reaction ………
Chronic e ect ©
Delayed e ect (D)
27. Hypoglycemia due to insulin is an example Of which type of adverse drug
Reaction ……..

QUESTIONS
Chronic e ect ©
Delayed e ect (D)
28. Analgesic nephropathy is an example of Which type of adverse drug reaction………
Chronic e ect ©
Delayed e ect (D)
29. Bradycardia due to beta blockers is an example of which type of adverse drug
reaction ………
Chronic e ect ©
Delayed e ect (D)
30. Unstable angina after sudden stopping of beta blockers is an example of which
type of adverse drug reaction …….
Chronic e ect ©
Delayed e ect (D)

QUESTIONS
31. Adrenocortical insu iciency due to sudden Corticosteroids withdrawal is an

example Of which type of adverse drug Reaction …….
Chronic e ect ©
Delayed e ect (D)
32. Defined as an uncharacteristic, Non-immunological response to a drug That is not

related to its pharmacological Actions ……….
Side e ect
Adverse reaction
Idiosyncratic reaction
B and C
33. It is a secondary unwanted e ect that Occurs due to drug therapy.
Side e ect
Adverse reaction
Idiosyncratic reaction
E ective reaction
34. Very common of adverse drug reactions is More than……..
20%
10%
5%
30%

QUESTIONS
35. The uncommon in adverse drug reactions Is between………
0.1:1%
1:10 %
0.001:1%
0.5:1%
36. The common of adverse drug reactions is Between
1:5%
1:10 %
5:10%
2:5%
37. The distribution of drugs into the central Nervous system (brain) usually depends
on
Aqueous di usion
Lipid di usion
Active transport
Facilitated transport
38. Following intravenous administration, Drugs are distributed fastest to:
The skin, kidney, and brain
The liver, kidney, and brain
The liver, adipose, and brain
The liver, kidney, and adipose

QUESTIONS
39. A fundamental characteristic of all first Order pharmacokinetic processes is that

The rate of the process is proportional to Drug concentration:
False
True
40. Competition between two drugs for Binding to plasma protein(s) can result in a
Change in the concentration of free drug And potential drug toxicity.
True
False
41. Lipid soluble drugs are absorbed mainly by:
Passive di usion
Active transport
Filtration
Pinocytosis
42. An 18-year-old female patient is brought to The emergency department due to drug
Overdose. Which of the following routes ofAdministration is the most desirable
forAdministering the antidote for the drug Overdose?
Subcutaneous
Oral
Intravenous
Intramuscular
43. Most drugs gain entry to cells by:
Passive di usion with zero-order Kinetics
Passive di usion through membrane Pores

QUESTIONS
Passive di usion with first-order Kinetics
Active transport with first-order kinetics
Active transport with zero-orderKinetics
44. Distribution is a ected by all the following Factors EXCEPT:
Lipid solubility of the drug
Lonization of the drug
Plasma protein binding of the drug
First-pass metabolism
45. Absorption is a ected by all the following Factors EXCEPT:
Blood supply
Lipid solubility
Plasma protein binding
Presence of food
46. Drug toxicity is more with:
Drug with plasma protein binding 50%
47. Drugs that are highly bound to albumin:
Have a large Vd
Can undergo competition with other
Drugs for albumin binding sites

QUESTIONS
E ectively cross the BBB
Are easily filtered at the glomerulus
48. Slow metabolizers are more liable to:
Failure to reach to the therapeutic
E ective levels
Drug accumulation
Therapeutic failure
Renal failure
49. Liver enzyme inducers increase the e ect Of:
Lipid soluble drugs
Prodrugs
February 8
All drugs
Water soluble drugs
50. Phase I reaction includes all the following types of reactions except:
Conjugation
Reduction
Oxidation
Hydrolysis
166 answers
51. Biotransformation usually leads to:
Decrease in the lipid solubility of the Drug

QUESTIONS
Increase in the lipid solubility of the Drug
Decrease in water solubility of the drug
Increase in the activity of all drugs
52. The main organ which is responsible for Drug metabolism is:
GIT
Lung
Kidney
Liver
53. Bioavailability is a ected by all the Following factors EXCEPT
First-pass metabolism
Lipid solubility of the drug
Presence of food
Plasma protein binding of the drug
54. The fraction of a given dose that reaches Systemic circulation is:
The clearance
The bioavailability
The half-life
Volume of distribution
55. If t1/2 of a drug is 2 days, the Css is Reached after:
5 days
9 days
12 hours

QUESTIONS
2 days
56. If the t ½ of a drug is 30 hours, one of the Followings is false:
Css is reached after 5-6 days
This drug has low Vd and large rate of Clearance
The drug is used every 24 h.
If the drug has constant clearance, it is Easy to maintain Css
57. If the T1/2 of a drug is 18 h, it is better to Give this drug every:
6h
24 h
12 h
10 h
58. The loading dose depends on:
T1/2
Vd
CI
59. The maintenance dose depends on:
CI
Vd
T1/2

QUESTIONS
60. We stopped the use of certain drug when Plasma concentration is 100 mg. What is
The plasma concentration of this drug after 20 h if the t 1/5 is 5 h?
The pharmacokinetic Properties of five new drugs (P, Q, R, S, And T) were studied in Healthy
volunteers. The same Dose of Each drug was administered Intravenously (IV) and orally To
The same subject on two Separate occasions. The Results were The following:
61. Which of the following drugs most likely Has the highest oral Bioavailability?
Drug P
Drug Q
Drug R
Drug S
Drug T

QUESTIONS
Time During a phase 1 clinical trial,Four di erent oral dosage Forms of the same dose of a
drug were administered to a healthy volunteer on four Separate occasions. The Plasma
Concentration-time curves are plotted below.
62. Which of the following features best Explains why formulation W produces the
largest plasma Concentration-time curve Of the drug?
Highest absorption through gut wall
Lowest first-pass e ect
Lowest hepatic clearance
Highest volume of distribution
Lowest drug elimination
A 67-year-old woman recently Diagnosed with atrial fibrillation Started treatment with
atenolol, 100 Mg/d. With this Dose, the percentage of atenolol Bound to plasma proteins Is
about 5%.

QUESTIONS
63. Which of the following would have been The Bound percentage of atenolol if a dose
of 50 mg/d had been Administered to the same patient?
2.5%
5%
10%
1.25%
2%
Drug
The ability of five di erent drugs (P, Q, R, S, and T) to cross
The placenta was studied In laboratory animals. The Following Data were obtained.
64. Which of the following drugs most likely Crossed the placenta At the fastest rate?
Drug P
Drug Q
Drug R
Drug S
Drug T

QUESTIONS
The pharmacokinetic Properties of five new drugs (P, Q, R, S. And T) were studied in
Laboratory animals. The drugs Were Given orally, and the results Are shown above.
Which of the following drugs most likely Has the highest oral Bioavailability?
Drug P
Drug S
Drug Q
Drug R
Drug T
The pharmacokinetics of a new drug That followed first-order,one-compartment model

kinetics Was studied in a healthy Volunteer. A 20-mg dose was given Intravenously. The
plasma Concentration of the drug turned out
To be 2 mg/L initially And 1 mg/L 2 hours later.
65. Which of the following was most Likely the total clearance of the drug (in L/ h)?
2.5
8.4
5.5
6.7

QUESTIONS
3.5
4.9
The figure above depicts the Plasma concentration-time Curves for four drugs (W, X,Y,and
Z) given by IV infusion to the same laboratory animal On four separate occasions
66. Which of the following drugs has the Shortest half-life?
Drug W
Drug X
Drug Y

‫‪QUESTIONS‬‬
‫‪Drug Z‬‬

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QUESTIONS

2) The reasons determining Bioavailability

3) Most of drugs are distributed homogeneously

4) What does pharmacokinetics include?

‫تم تجميع اﻻسئلة بواسطة فريق اﻷفق الطبي‬

6) Hydrophilic medical agents has one of the following properties

7) Estimulation of liver microsomal enzymes

8) Pick out the right statement

9) Biotransformation of drug is to render them

10) The term "Biotransformation" include the following

11) A small amount of volium of distribution(Vd)is common for lipophylic

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12) For calculation od (Vd) one muat take into account

13) The volume of distribution (vd) relates Anonymous Quiz

14) The e ect of the body on the drugmeans...........

15) The pharmacokinetic includes ..........

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19) The increasing of ........... follow by .......... In absorption of drug.

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27) Alkalinization of the urine......... the excretion on......... drugs.

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28) Alkalinization of the urine ......... the excretion on ........ drugs.

29) Acidiﬁcation of the urine.......... the excretion on ......... drugs.

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37) The bioavailability or (F) = ........

38) The most common site of metabolism is the .........

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42) All of the following have a high perfusion rate except.........

45) The acidic drugs like (salicylates)are bound to ..........

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48) The human body is a homogeneous compartment.

49) The amount of the drug in the body / plasma concentration =

51) In the large Vd the half-life of drug is a short period.

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58) What is the loading dose required for drug

59) Css ...........

60) ....... Is the target average steady statedrug concentration.

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64) The water soluble drugs are more easily to Excreted.

66) In the (most) drugs, the conversion of a Pharmacologically from……….. to………

68) The enalapril converted to enalaprilat is an Example of conversion of a

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iii) Inactive – active

69) The diazepam changed to oxazepam is an Example of conversion of a

70) The active drug is named a prodrug.

71) The most important organ of Biotransformation is the ………

73) The lungs is not a site of Biotransformation.

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75) The sulphate conjugation is an (important) Example of ……….. biotransformation.

76) The MAO is an (important) example Of ………. Biotransformation.

77) All of following are Phase 1 of biotransformation except…….

78) Are………. Of biotransformation.

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82) The microsomal enzymes are just located In the liver.

83) The Ethanol is inactivated by alcohol Dehydrogenase, Succinylcholine by plasma

85) The erythromycin, ketokonazole, Cimetidine are an example of ………