Revision date: 08/09/2022 Revision: 1

SAFETY DATA SHEET

1-Bromobutane
According to the REACH etc. (Amendment etc.) (EU Exit) Regulations 2020 No. 1577, as amended.

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier

Product name 1-Bromobutane

Synonyms; trade names Butyl bromide

CAS number 109-65-9

EC number 203-691-9

1.2. Relevant identified uses of the substance or mixture and uses advised against
Identified uses Research and development.

Uses advised against Not suitable for human consumption or veterinary purposes.

1.3. Details of the supplier of the safety data sheet

Supplier Molekula Ltd.
Lingfield Way,
Darlington,
DL1 4XX,
United Kingdom
+44 (0) 3302000333
[email protected]

1.4. Emergency telephone number

+44 (0) 7769276927

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture

Classification (SI 2019 No. 720)
Physical hazards Flam. Liq. 2 - H225

Health hazards Skin Irrit. 2 - H315 Carc. 2 - H351 Repr. 1B - H360FD STOT SE 3 - H335 STOT RE 2 - H373

Environmental hazards Aquatic Chronic 2 - H411

2.2. Label elements

EC number 203-691-9

Hazard pictograms

Signal word Danger

1/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

Hazard statements H225 Highly flammable liquid and vapour.

H315 Causes skin irritation.
H351 Suspected of causing cancer.
H360FD May damage fertility by inhalation. May damage the unborn child by inhalation.
H335 May cause respiratory irritation.
H373 May cause damage to organs (Liver) through prolonged or repeated exposure if
inhaled.
H411 Toxic to aquatic life with long lasting effects.

Precautionary statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No
smoking.
P260 Do not breathe vapour/ spray.
P264 Wash contaminated skin thoroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing.
Rinse skin with water or shower.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P308+P313 IF exposed or concerned: Get medical advice/ attention.
P312 Call a POISON CENTRE/doctor if you feel unwell.
P332+P313 If skin irritation occurs: Get medical advice/ attention.
P370+P378 In case of fire: Use foam, carbon dioxide, dry powder or water fog to extinguish.
P391 Collect spillage.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/ container in accordance with national regulations.

2.3. Other hazards

This substance is not classified as PBT or vPvB according to current UK criteria.

SECTION 3: Composition/information on ingredients

3.1. Substances
Product name 1-Bromobutane

CAS number 109-65-9

EC number 203-691-9

Chemical formula CH3(CH2)3Br

SECTION 4: First aid measures

4.1. Description of first aid measures

General information Get medical attention if any discomfort continues. Show this Safety Data Sheet to the medical
personnel.

Inhalation Move affected person to fresh air and keep warm and at rest in a position comfortable for
breathing. Maintain an open airway. Loosen tight clothing such as collar, tie or belt. When
breathing is difficult, properly trained personnel may assist affected person by administering
oxygen. Get medical attention. Place unconscious person on their side in the recovery
position and ensure breathing can take place.

2/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

Ingestion Rinse mouth thoroughly with water. Give a few small glasses of water or milk to drink. Stop if
the affected person feels sick as vomiting may be dangerous. Never give anything by mouth
to an unconscious person. Place unconscious person on their side in the recovery position
and ensure breathing can take place. Keep affected person under observation. Get medical
attention if symptoms are severe or persist.

Skin contact Rinse with water.

Eye contact Remove any contact lenses and open eyelids wide apart. Rinse with water. Get medical
attention if any discomfort continues.

Protection of first aiders First aid personnel should wear appropriate protective equipment during any rescue.

4.2. Most important symptoms and effects, both acute and delayed
General information The severity of the symptoms described will vary dependent on the concentration and the
length of exposure.

Inhalation A single exposure may cause the following adverse effects: Irritation of nose, throat and
airway. Difficulty in breathing. Coughing. Prolonged or repeated exposure may cause the
following adverse effects: Suspected of causing cancer.

Ingestion May cause irritation. Prolonged or repeated exposure may cause the following adverse
effects: Suspected of causing cancer.

Skin contact Redness. Irritating to skin. Prolonged or repeated exposure may cause the following adverse
effects: Suspected of causing cancer.

Eye contact May be slightly irritating to eyes.

4.3. Indication of any immediate medical attention and special treatment needed
Notes for the doctor Treat symptomatically.

SECTION 5: Firefighting measures

5.1. Extinguishing media

Suitable extinguishing media The product is flammable. Extinguish with alcohol-resistant foam, carbon dioxide, dry powder
or water fog. Use fire-extinguishing media suitable for the surrounding fire.

Unsuitable extinguishing Do not use water jet as an extinguisher, as this will spread the fire.
media

5.2. Special hazards arising from the substance or mixture

Specific hazards Containers can burst violently or explode when heated, due to excessive pressure build-up.
Flammable liquid and vapour. Vapours may be ignited by a spark, a hot surface or an ember.
Vapours may form explosive mixtures with air. Fire-water run-off in sewers may create fire or
explosion hazard. Vapours are heavier than air and may spread near ground and travel a
considerable distance to a source of ignition and flash back.

Hazardous combustion Thermal decomposition or combustion products may include the following substances:
products Harmful gases or vapours. Oxides of carbon. Hydrogen bromide (HBr).

5.3. Advice for firefighters

3/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

Protective actions during Avoid breathing fire gases or vapours. Evacuate area. Keep upwind to avoid inhalation of
firefighting gases, vapours, fumes and smoke. Ventilate closed spaces before entering them. Cool
containers exposed to heat with water spray and remove them from the fire area if it can be
done without risk. Cool containers exposed to flames with water until well after the fire is out.
If a leak or spill has not ignited, use water spray to disperse vapours and protect men stopping
the leak. Avoid discharge to the aquatic environment. Control run-off water by containing and
keeping it out of sewers and watercourses. If risk of water pollution occurs, notify appropriate
authorities.

Special protective equipment Wear positive-pressure self-contained breathing apparatus (SCBA) and appropriate protective
for firefighters clothing. Firefighter's clothing will provide a basic level of protection for chemical incidents.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures

Personal precautions Wear protective clothing as described in Section 8 of this safety data sheet. No action shall be
taken without appropriate training or involving any personal risk. Do not touch or walk into
spilled material. Evacuate area. Provide adequate ventilation. No smoking, sparks, flames or
other sources of ignition near spillage. Promptly remove any clothing that becomes
contaminated. Avoid inhalation of vapours and spray/mists. Use suitable respiratory protection
if ventilation is inadequate.

6.2. Environmental precautions

Environmental precautions Avoid discharge into drains or watercourses or onto the ground. Avoid discharge to the
aquatic environment.

6.3. Methods and material for containment and cleaning up

Methods for cleaning up Wear protective clothing as described in Section 8 of this safety data sheet. Clear up spills
immediately and dispose of waste safely. Eliminate all ignition sources if safe to do so. No
smoking, sparks, flames or other sources of ignition near spillage. Do not allow material to
enter confined spaces, due to the risk of explosion. Absorb small quantities with paper towels
and evaporate in a safe place. Once evaporation is complete, place paper in a suitable waste
disposal container and seal securely. Large Spillages: If the product is soluble in water, dilute
the spillage with water and mop it up. Alternatively, or if it is not water-soluble, absorb the
spillage with an inert, dry material and place it in a suitable waste disposal container. The
contaminated absorbent may pose the same hazard as the spilled material. Label the
containers containing waste and contaminated materials and remove from the area as soon
as possible. Flush contaminated area with plenty of water. Wash thoroughly after dealing with
a spillage. Dangerous for the environment. Do not empty into drains. For waste disposal, see
Section 13.

6.4. Reference to other sections

Reference to other sections For personal protection, see Section 8. See Section 11 for additional information on health
hazards. See Section 12 for additional information on ecological hazards. For waste disposal,
see Section 13.

SECTION 7: Handling and storage

7.1. Precautions for safe handling

4/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

Usage precautions Read and follow manufacturer's recommendations. Wear protective clothing as described in
Section 8 of this safety data sheet. Keep away from food, drink and animal feeding stuffs.
Handle all packages and containers carefully to minimise spills. Keep container tightly sealed
when not in use. Avoid the formation of mists. The product is flammable. Keep away from
heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Suspected of
causing cancer. May damage fertility. May damage the unborn child. Pregnant or
breastfeeding women should not work with this product if there is any risk of exposure. Avoid
discharge to the aquatic environment. Do not handle until all safety precautions have been
read and understood. Do not handle broken packages without protective equipment. Do not
reuse empty containers.

Advice on general Wash promptly if skin becomes contaminated. Take off contaminated clothing. Wash
occupational hygiene contaminated clothing before reuse.

7.2. Conditions for safe storage, including any incompatibilities

Storage precautions Store away from incompatible materials (see Section 10). Store locked up. Keep away from
oxidising materials, heat and flames. Keep only in the original container. Keep container
tightly closed, in a cool, well ventilated place. Keep containers upright. Protect containers from
damage.

Storage class Flammable liquid storage.

7.3. Specific end use(s)

Specific end use(s) The identified uses for this product are detailed in Section 1.2.

SECTION 8: Exposure controls/Personal protection

8.1. Control parameters

8.2. Exposure controls

Protective equipment

Appropriate engineering Provide adequate general and local exhaust ventilation. Ensure the ventilation system is
controls regularly maintained and tested. Good general ventilation should be adequate to control
worker exposure to airborne contaminants. Observe any occupational exposure limits for the
product or ingredients.

Eye/face protection Unless the assessment indicates a higher degree of protection is required, the following
protection should be worn: Tight-fitting safety glasses.

Hand protection Wear protective gloves. The most suitable glove should be chosen in consultation with the
glove supplier/manufacturer, who can provide information about the breakthrough time of the
glove material. To protect hands from chemicals, wear gloves that are proven to be
impervious to the chemical and resist degradation. Considering the data specified by the
glove manufacturer, check during use that the gloves are retaining their protective properties
and change them as soon as any deterioration is detected. Frequent changes are
recommended.

Other skin and body Wear appropriate clothing to prevent repeated or prolonged skin contact.
protection

Hygiene measures Wash after use and before eating, smoking and using the toilet. Do not eat, drink or smoke
when using this product.

5/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

Respiratory protection Ensure all respiratory protective equipment is suitable for its intended use and is ‘UKCA’-
marked. Check that the respirator fits tightly and the filter is changed regularly. Gas and
combination filter cartridges suitable for intended use should be used. Full face mask
respirators with replaceable filter cartridges suitable for intended use should be used. Half
mask and quarter mask respirators with replaceable filter cartridges suitable for intended use
should be used.

Environmental exposure Keep container tightly sealed when not in use. Emissions from ventilation or work process
controls equipment should be checked to ensure they comply with the requirements of environmental
protection legislation. In some cases, fume scrubbers, filters or engineering modifications to
the process equipment will be necessary to reduce emissions to acceptable levels.

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties

Appearance Clear liquid.

Colour Colourless to pale yellow.

Odour Not known.

Odour threshold No information available.

pH No information available.

Melting point -112°C/-170°F

Initial boiling point and range 101°C/214°F

Flash point 10°C / 50°F Method: Closed cup.

Evaporation rate No information available.

Flammability (solid, gas) No information available.

Upper/lower flammability or No information available.

explosive limits

Vapour pressure 5595.54 Pa @ 25°C/77°F

Vapour density No information available.

Relative density 1.269 @ 20°C/68°F

Solubility(ies) 869 mg/l water @ 25°C/77°F

Partition coefficient log Pow: 2.75

Auto-ignition temperature 265°C/509°F

Decomposition Temperature No information available.

9.2. Other information

Molecular weight 137.02

SECTION 10: Stability and reactivity

10.1. Reactivity
Reactivity See the other subsections of this section for further details.

10.2. Chemical stability

Stability Stable at normal ambient temperatures and when used as recommended. Stable under the
prescribed storage conditions.

6/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

10.3. Possibility of hazardous reactions

Possibility of hazardous The following materials may react strongly with the product: Oxidising agents.
reactions Exothermic reaction with:
Alkali metals.
Alkaline earth metals.
Powdered metal.
Strong oxidising agents.

10.4. Conditions to avoid

Conditions to avoid Avoid heat, flames and other sources of ignition. Containers can burst violently or explode
when heated, due to excessive pressure build-up. Static electricity and formation of sparks
must be prevented.

10.5. Incompatible materials

Materials to avoid Oxidising materials. Acids - oxidising.

10.6. Hazardous decomposition products

Hazardous decomposition Does not decompose when used and stored as recommended. Thermal decomposition or
products combustion products may include the following substances: Harmful gases or vapours.
Oxides of carbon. Hydrogen bromide (HBr).

SECTION 11: Toxicological information

11.1. Information on toxicological effects

Acute toxicity - oral
Summary Based on available data the classification criteria are not met.

Acute toxicity - dermal

Summary Based on available data the classification criteria are not met.

Acute toxicity - inhalation

Summary Based on available data the classification criteria are not met.

Skin corrosion/irritation
Summary Causes skin irritation.

Serious eye damage/irritation

Summary Based on available data the classification criteria are not met.

Respiratory sensitisation
Summary Based on available data the classification criteria are not met.

Skin sensitisation
Summary Based on available data the classification criteria are not met.

Germ cell mutagenicity

Summary Based on available data the classification criteria are not met.

Carcinogenicity
Summary Suspected of causing cancer.

IARC carcinogenicity None of the ingredients are listed or exempt.

Reproductive toxicity
Summary May damage the unborn child. May damage fertility.

Specific target organ toxicity - single exposure

7/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

Summary May cause respiratory irritation.

Target organs Respiratory system, lungs

Specific target organ toxicity - repeated exposure

Summary May cause damage to organs through prolonged or repeated exposure.

Aspiration hazard
Summary Based on available data the classification criteria are not met.

General information Avoid contact during pregnancy/while nursing. May damage fertility. May cause cancer after
repeated exposure. Risk of cancer depends on duration and level of exposure. The severity of
the symptoms described will vary dependent on the concentration and the length of exposure.

Inhalation A single exposure may cause the following adverse effects: Irritation of nose, throat and
airway. Difficulty in breathing. Coughing.

Ingestion May cause irritation.

Skin contact Redness. Irritating to skin.

Eye contact May be slightly irritating to eyes.

Route of exposure Ingestion Inhalation Skin and/or eye contact

Target organs Respiratory system, lungs

SECTION 12: Ecological information

12.1. Toxicity
Acute aquatic toxicity
Summary Based on available data the classification criteria are not met.

Acute toxicity - fish NOEC, 96 hours: 1.77 mg/l, Oncorhynchus mykiss (Rainbow trout)

Acute toxicity - aquatic EC₅₀, 48 hours: 99.3 mg/l, Daphnia magna

invertebrates

Acute toxicity - aquatic plants NOEC, 72 hours: 1.93 mg/l, Pseudokirchneriella subcapitata

Chronic aquatic toxicity

Summary Toxic to aquatic life with long lasting effects.

12.2. Persistence and degradability

Persistence and degradability The degradability of the product is not known.

12.3. Bioaccumulative potential

Bioaccumulative potential No data available on bioaccumulation.

Partition coefficient log Pow: 2.75

12.4. Mobility in soil

Mobility No data available.

12.5. Results of PBT and vPvB assessment

Results of PBT and vPvB This product does not contain any substances classified as PBT or vPvB.
assessment

12.6. Other adverse effects

Other adverse effects None known.

8/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

SECTION 13: Disposal considerations

13.1. Waste treatment methods

General information The generation of waste should be minimised or avoided wherever possible. Reuse or recycle
products wherever possible. This material and its container must be disposed of in a safe
way. When handling waste, the safety precautions applying to handling of the product should
be considered. Care should be taken when handling emptied containers that have not been
thoroughly cleaned or rinsed out. Empty containers or liners may retain some product
residues and hence be potentially hazardous.

Disposal methods Do not empty into drains. Dispose of surplus products and those that cannot be recycled via a
licensed waste disposal contractor. Waste, residues, empty containers, discarded work
clothes and contaminated cleaning materials should be collected in designated containers,
labelled with their contents. Incineration or landfill should only be considered when recycling is
not feasible.

SECTION 14: Transport information

General For limited quantity packaging/limited load information, consult the relevant modal
documentation using the data shown in this section.

14.1. UN number
UN No. (ADR/RID) 1126

UN No. (IMDG) 1126

UN No. (ICAO) 1126

UN No. (ADN) 1126

14.2. UN proper shipping name

Proper shipping name 1-BROMOBUTANE
(ADR/RID)

Proper shipping name (IMDG) 1-BROMOBUTANE

Proper shipping name (ICAO) 1-BROMOBUTANE

Proper shipping name (ADN) 1-BROMOBUTANE

14.3. Transport hazard class(es)

ADR/RID class 3

ADR/RID classification code F1

ADR/RID label 3

IMDG class 3

ICAO class/division 3

ADN class 3

Transport labels

14.4. Packing group

ADR/RID packing group II

9/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

IMDG packing group II

ICAO packing group II

ADN packing group II

14.5. Environmental hazards

Environmentally hazardous substance/marine pollutant

14.6. Special precautions for user

Always transport in closed containers that are upright and secure. Ensure that persons transporting the product know what to
do in the event of an accident or spillage.

IMDG Code segregation 10. Liquid halogenated hydrocarbons

group

EmS F-E, S-D

ADR transport category 2

Emergency Action Code 2YE

Hazard Identification Number 33

(ADR/RID)

Tunnel restriction code (D/E)

14.7. Transport in bulk according to Annex II of MARPOL and the IBC Code
Transport in bulk according to Not applicable.
Annex II of MARPOL 73/78
and the IBC Code

SECTION 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulations Health and Safety at Work etc. Act 1974 (as amended).
The Carriage of Dangerous Goods and Use of Transportable Pressure Equipment
Regulations 2009 (SI 2009 No. 1348) (as amended) ["CDG 2009"].
EH40/2005 Workplace exposure limits.

15.2. Chemical safety assessment

No chemical safety assessment has been carried out.

Inventories
EU - EINECS/ELINCS
None of the ingredients are listed or exempt.

SECTION 16: Other information

10/11
Revision date: 08/09/2022 Revision: 1

1-Bromobutane

Abbreviations and acronyms ADR: European Agreement concerning the International Carriage of Dangerous Goods by
used in the safety data sheet Road.
ADN: European Agreement concerning the International Carriage of Dangerous Goods by
Inland Waterways.
RID: European Agreement concerning the International Carriage of Dangerous Goods by Rail.
IATA: International Air Transport Association.
ICAO: Technical Instructions for the Safe Transport of Dangerous Goods by Air.
IMDG: International Maritime Dangerous Goods.
CAS: Chemical Abstracts Service.
ATE: Acute Toxicity Estimate.
LC50: Lethal Concentration to 50 % of a test population.
LD50: Lethal Dose to 50% of a test population (Median Lethal Dose).
EC₅₀: 50% of maximal Effective Concentration.
PBT: Persistent, Bioaccumulative and Toxic substance.
vPvB: Very Persistent and Very Bioaccumulative.

Classification abbreviations Flam. Liq. = Flammable liquid

and acronyms Carc. = Carcinogenicity
Repr. = Reproductive toxicity
Skin Irrit. = Skin irritation
STOT RE = Specific target organ toxicity-repeated exposure
STOT SE = Specific target organ toxicity-single exposure
Aquatic Chronic = Hazardous to the aquatic environment (chronic)

Classification procedures STOT RE 2 - H373: STOT SE 3 - H335: Skin Irrit. 2 - H315: Carc. 2 - H351: Repr. 1B -
according to SI 2019 No. 720 H360FD: : Expert judgement. Aquatic Chronic 2 - H411: : Expert judgement. Flam. Liq. 2 -
H225: : Expert judgement.

Training advice Only trained personnel should use this material.

Revision date 08/09/2022

Revision 1

SDS number 1479

Hazard statements in full H225 Highly flammable liquid and vapour.

H315 Causes skin irritation.
H335 May cause respiratory irritation.
H351 Suspected of causing cancer.
H360FD May damage fertility by inhalation. May damage the unborn child by inhalation.
H373 May cause damage to organs (Liver) through prolonged or repeated exposure if
inhaled.
H411 Toxic to aquatic life with long lasting effects.

This information relates only to the specific material designated and may not be valid for such material used in combination
with any other materials or in any process. Such information is, to the best of the company's knowledge and belief, accurate
and reliable as of the date indicated. However, no warranty, guarantee or representation is made to its accuracy, reliability or
completeness. It is the user's responsibility to satisfy himself as to the suitability of such information for his own particular use.

11/11