General Biology 2 Module 4
General Biology 2 Module 4
General Biology 2 Module 4
General Biology 2
Quarter 4 – Module 4:
Plant and Animal Organismal
Biology
1
General Biology 2 - Grade 11/12
Alternative Delivery Mode
Quarter 2 - Module 4: Compare and Contrast Processes in Plants and Animals Immune
System and Sensory and Motor Mechanisms
Republic Act 8293, Section 176 states that: No copyright shall subsist in any work of the
Government of the Philippines. However, prior approval of the government agency or office
wherein the work is created shall be necessary for exploitation of such work for profit. Such
agency or office may, among other things, impose a condition the payment of royalties.
Borrowed materials (i.e. songs, stories, poems, pictures, brand names, trademarks, etc.)
included in this module are owned by their respective copyright holders. Every effort has been
exerted to locate and seek permission to use these materials from their respective copyright
owners. The publisher and authors do not represent nor claim ownership over them.
2
General Biology 2
Quarter 2 – Module 4:
Comparing Plant and Animal
Processes:
Immune System;
Sensory and Motor Mechanisms
3
FOREWORD
This learning resource hopes to engage the learners into guided and
independent learning activities at their own pace and time. Furthermore, this
also aims to help learners acquire needed 21st century skills while taking into
consideration their needs and circumstances.
As a facilitator, you are expected to orient the learners on how to use this
module. You also need to keep track of the learners’ progress while allowing them
to encourage their own learning. Furthermore, you are expected to encourage
and assist the teachers as they do tasks included in the module.
This module was designed to provide you with fun and meaningful
opportunities for guided and independent learning at your own pace and time.
You will be enabled to process the contents of the learning resource while being
an active learner.
4
This part includes an activity that aims to
check what you already know about the
What I Know
lesson. If you get all the answers correct
(100%), you may decide to skip this module.
This is a brief drill or review to help you link
What’s In the current lesson with the previous one.
5
In this portion, another activity will be given
Additional to you to enrich your knowledge or skill of
Activities the lesson learned.
6
Lesson 1: Comparing Plant and
Animal Processes: Immune System
Learning Competency
The learners shall be able to explain how immune systems work
(STEM_BIO11/12-IVa-h-1)
What I Know
Arrange the jumbled letters of the following terms involved with the Immune System
7
What’s In
Previously on Module 3, you have explored how plants and animals regulate body fluids. More especially
on the excretory system of humans.
1. What are the possible consequences should there be a failure in the ability of the body
to dispose or eliminate toxic metabolic wastes?
2. List the organs that make up the human urinary system.
3. Identify the three types of nitrogenous wastes excreted by animals.
What’s New
What Is It
The immune system is typically divided into two categories--innate and adaptive--although these
distinctions are not mutually exclusive.
8
Innate Immunity
Innate immunity refers to nonspecific defense mechanisms that come into play immediately or within
hours of an antigen's appearance in the body. Barrier defenses like the skin, mucous membranes and
secretions. In humans and in most vertebrates, the skin with other ectodermal derivatives is the first line
of defense against infection. The innate immune response acts fast, but never changes from exposure to
exposure.
Adaptive Immunity
Adaptive immunity involves the recognition of traits specific to particular pathogens using a vast array of
receptors. Once an antigen has been recognized, the adaptive immune system creates an army of immune
cells specifically designed to attack that antigen. Adaptive immunity also includes a "memory" that makes
future responses against a specific antigen more efficient.
Human antibodies are classified into five isotypes (IgM, IgD, IgG, IgA, and IgE) according to their H chains,
which provide each isotype with distinct characteristics and roles.
IgG
IgG is the most abundant antibody isotype in the blood (plasma), accounting for 70-75% of human
immunoglobulins (antibodies). IgG detoxifies harmful substances and is important in the recognition of
antigen-antibody complexes by leukocytes and macrophages. IgG is transferred to the fetus through the
placenta and protects the infant until its own immune system is functional.
9
IgM
IgM usually circulates in the blood, accounting for about 10% of human immunoglobulins. IgM has a
pentameric structure in which five basic Y-shaped molecules are linked together. B cells produce IgM first
in response to microbial infection/antigen invasion.
Although IgM has a lower affinity for antigens than IgG, it has higher avidity for antigens because of its
pentameric/hexameric structure. IgM, by binding to the cell surface receptor, also activates cell signaling
pathways.
IgA
IgA is abundant in serum, nasal mucus, saliva, breast milk, and intestinal fluid, accounting for 10-15% of
human immunoglobulins. IgA forms dimers (i.e., two IgA monomers joined together). IgA in breast milk
protects the gastrointestinal tract of neonates from pathogens.
IgE
IgE is present in minute amounts, accounting for no more than 0.001% of human immunoglobulins. Its
original role is to protect against parasites. In regions where parasitic infection is rare, IgE is primarily
involved in allergy.
IgD
IgD accounts for less than 1% of human immunoglobulins. IgD may be involved in the induction of antibody
production in B cells, but its exact function remains unknown.
T cell: A type of white blood cell that is of key importance to the immune system and is at the core of
adaptive immunity, the system that tailors the body's immune response to specific pathogens. The T cells
are like soldiers who search out and destroy the targeted invaders.
Immature T cells (termed T-stem cells) migrate to the thymus gland in the neck, where they mature and
differentiate into various types of mature T cells and become active in the immune system in response to
a hormone called thymosin and other factors. T-cells that are potentially activated against the body's own
tissues are normally killed or changed ("down-regulated") during this maturational process.
There are 3 main types of T cells: cytotoxic, helper, and regulatory. Each of them has a different role in
the immune response.
Cytotoxic T cells (Tc cells) recognize virus-infected cells and kill them. They have a co-receptor called CD8
on their cell surface. CD8 partners with the T cell receptor and with MHC (Major Histocompatibility
Complex) class I molecules, acting as a sort of bridge. This bridge allows cytotoxic T cells to recognize
normal cells that are infected by a pathogen. When the cytotoxic T cell recognizes the infected cell, it
becomes activated and produces molecules that kill the infected cell, destroying the pathogen in the
process.
10
Helper T Cells (CD4+)
Helper T cells (Th cells) cells secrete proteins that help other immune cells (B cells, macrophages, etc.)
survive and perform their function. They have a different co-receptor called CD4 on their cell surface. CD4
also partners with the T cell receptor but interacts with MHC class II molecules instead of MHC class I
molecules. This allows helper T cells to recognize pathogen peptides that have been displayed by antigen
presenting cells. When helper T cells recognize a peptide on an antigen presenting cell, they become
activated and begin to produce molecules called cytokines that signal to other immune cells.
11
Regulatory T Cells
Regulatory T cells (Treg cells) play a protective role by shutting off the immune response when it is no
longer needed. This prevents excessive damage to the normal cells and tissues in the body. Regulatory T
cells suppress the immune response in several ways, including:
What’s More
Were you amazed by what our immune system does in order to protect our body from potentially harmful
foreign bodies?
Below are some questions that needs to be answered regarding the immune system, answer the following
on a separate sheet of paper:
b. What happens when you get vaccinated? How does a person get antibodies upon
vaccination? _____________________________________________________________
________________________________________________________________________
12
What I Can Do
Due to the recent pandemic our world is going through, and with your knowledge on immune system
response, you have learned that through acquired immunity, humans can combat the COVID 19 virus.
However, a lot of under-educated, misinformed persons do not agree with the use of vaccines on humans.
In your point of view, do you think vaccines would help mitigate the pandemic brought by the COVID 19
virus? How can you encourage the misinformed people to get their vaccines too?
Assessment
Choose the letter of the correct answer. Write your answer on a separate piece of paper.
13
B. histamines
C. antigens
D. T-cells
6. Pathogens can be:
A. bacteria and viruses
B. viruses and protists
C. protists and fungi
D. all of the these
7. Typically, people only get chicken pox once in their lives. Why do individuals not repeatedly fall
victim to this illness?
A. the nonspecific immune system has become more powerful
B. memory B-cells produce antibodies more rapidly upon second exposure
C. after the first infection by the virus, the body never comes in contact with the pathogen
D. viruses are more likely to cause damage to young children than adults
8. The cells that are responsible for producing antibodies are:
A. B- lymphocytes
B. T-Lymphocytes
C. macrophages
D. phagocytes
9. Many bacteria that enter the circulatory system are engulfed and destroyed by
A. antibodies
B. platelets
C. phagocytes
D. phagocytic red blood cells
10. The most effective attacking cells in the immune system are:
A. helper T-cells
B. B cells
C. killer T-cells
D. mast cells
11. Smallpox appears to have been eliminated as a disease by the use of:
A. vaccines
B. antibiotics
C. interferon
D. parasites
12. What type of B cell remains dormant in the body, but can respond rapidly if the same antigen
appears again?
A. T cells
B. Memory Cells
C. Plasma Cells
D. Macrophages
13. The maturation of T cells and the production of particular T cell receptors occurs in the_______.
A. Thyroid gland
B. Thymus gland
C. Testes
D. All of the above
14. Which of the following provide specific defense against viruses and bacteria?
A. T cells
B. Red blood cells
14
C. Complement
D. Inflammation
15. What is the result of invasion of a body by pathogens?
A. Infection
B. Death
C. Fainting
D. Pus
Additional Activities
To further enhance your learning, make a comic strip drawing showing the different types of antibodies
and the roles they play in the immune response.
15
16
What I Have Learned
a. The immune system will start
to activate its 2nd and 3rd
defenses which involves the
activation of B cells and T
cells in order to attack and
control the infection.
b. Upon vaccination, the
macrophages will subjugate
What’s New the foreign body and the
memory B cells will record the Assessment
1. Refers to the invasion and growth
response pathway so that when 1. D
of microorganisms in a body
another infection comes, the 2. D
2. Refers to the ability of am
memory B cells will trigger 3. A
organism to resist infection
the production of the specific 4. D
3. A subsystem of the immune
antibodies for the foreign 5. C
system that utilizes previous
body. 6. D
infections to create a better
response to the secondary infection 7. B
4. Refers to production and secretion What’s More 8. A
of antibodies or immunoglobulins 9. C
against specific antigens 1. Thymus 10. C
5. A subsystem of the immune 2. Major Histocompatibility 11. A
system that responds first to any Complex 12. B
infection, includes the barrier 3. These are self-molecules that is 13. B
defenses. being recognized by the T cells 14. A
6. These are produced by cells that for it to be acted upon 15. A
secrete them in the bloodstream or 4. No T cells will be matured hence
display them in the surface of the cell mediated response of the
What I Know
some cells, ready to face and body will be affected.
combat any antigen 5. The killer t cells will become 1. Innate immune
7. Occurs when cytotoxic cells rampant and attach healthy cells response
defend the body against infection 2. Adaptive immune
through the development of B and What’s In response
T cells, memory cells and plasma 3. Immunity
cells 1. There could be accumulation 4. Humoral response
8. It is a substance / part of pathogen of toxic wastes in the body 5. Cell mediated
that generate an immune response. that would lead to m. response
Usually this response leads to the 2. Kidney, Ureter, Bladder, 6. Antibodies
production of a specific “antibody” Urethra 7. Antigen
for the given target. 3. Urea, Ammonia 8. infection
Answer Key
Lesson 2: Comparing Plant and
Animal Processes: Sensory and
Motor Mechanisms
The learners should be able to describe the structures involved in major animal
senses (STEM_BIO11/12-IVa-h-1)
What I Know
1. Photoreceptors
2. Mechanoreceptors
3. Chemoreceptors
4. Thermoreceptors
5. Pain receptors
17
What’s New
6 pics 1 Word. Identify the word that is being described in common by all of the pictures below.
What Is It
A major role of sensory receptors is to help us learn about the environment around us, or about
the state of our internal environment. Different types of stimuli from varying sources are received
and changed into the electrochemical signals of the nervous system. This process is called sensory
transduction.
Sensation is the activation of sensory receptors at the level of the stimulus. Perception is the
central processing of sensory stimuli into a meaningful pattern involving awareness. Perception
is dependent on sensation, but not all sensations are perceived.
18
Structural Receptor Types
The cells in the retina that respond to light stimuli are an example of a specialized receptor cell,
a photoreceptor.
An exteroceptor is a receptor that is located near a stimulus in the external environment, such
as the somatosensory receptors that are located in the skin.
An interoceptor is one that interprets stimuli from internal organs and tissues, such as the
receptors that sense the increase in blood pressure in the aorta or carotid sinus.
A proprioceptor is a receptor located near a moving part of the body, such as a muscle or joint
capsule, that interprets the positions of the tissues as they move.
Chemical stimuli can be detected by a chemoreceptor that detect chemical stimuli, such as a
chemical that lead to the sense of smell.
Physical stimuli, such as pressure and vibration, as well as the sensation of sound and body
position (balance), are interpreted through a mechanoreceptor.
Another physical stimulus that has its own type of receptor is temperature, which is sensed
through a thermoreceptor that is either sensitive to temperatures above (heat) or below (cold)
normal body temperature.
The three types of eyes that have evolved in the animal kingdom are:
I. Eye cups in flatworms and other invertebrates
II. Compound eyes in insects and arthropods
III. Single lens eyes in squid
The sclera is the outermost layer of the eyeball. It forms the white of the eye and in front, there
is a transparent cornea. The conjunctiva lines the eyelids and the front of the eyeball. It helps
keep the eyes moist. The sclera surrounds the choroid. The iris giving the eye its color, is formed
from the choroid. Vision starts when light passes through the pupil and into a transparent lens
that focuses images on the retina. The retina contains photoreceptor cells which transduce light
energy into action potentials. These nerve impulses travel along the optic nerve to the
corresponding visual areas of the brain. An image is then formed.
19
THE HUMAN EYE
The outer ear lobes catch sound waves and channel them to the eardrums. From the eardrum,
the middle ear amplifies the sound wave vibrations to three small bones – the hammer, anvil and
stirrup. The sound waves travel to the oval window. The Eustachian tube equalizes air pressure
in the middle ear and outer ear. The hearing organ is in the inner ear, composed of several
channels of fluid wrapped in a spiral cochlea. This is encased in the bones of the skull. Vibrations
in the oval window produce pressure waves. These waves travel through the upper canal to the
tip of the cochlea, enter the lower canal and fade away. Pressure waves of the upper canal push
down to the middle canal and the membrane below this canal vibrates. These vibrations
stimulate hair cells attached to the membrane by moving them against the overlying tissue. The
hair cells are able to develop receptor potentials causing release of neurotransmitters that induce
action potentials in the auditory neurons.
20
The Three Types of Skeleton
21
The Three Types of Muscle
About half of your body’s weight is muscle. In the muscular system, muscle tissue is categorized
into three distinct types: skeletal, cardiac, and smooth. Each type of muscle tissue in the human
body has a unique structure and a specific role.
A. Skeletal Muscle
Skeletal muscle, attached to bones, is responsible for skeletal movements. The peripheral
portion of the central nervous system (CNS) controls the skeletal muscles. Thus, these
muscles are under conscious, or voluntary, control. The basic unit is the muscle fiber with
many nuclei. These muscle fibers are striated (having transverse streaks) and each act
independently of neighboring muscle fibers.
B. Smooth Muscle
Smooth muscle, found in the walls of the hollow internal organs such as blood vessels, the
gastrointestinal tract, bladder, and uterus, is under control of the autonomic nervous system.
Smooth muscle cannot be controlled consciously and thus acts involuntarily. The non-striated
(smooth) muscle cell is spindle-shaped and has one central nucleus. Smooth muscle contracts
slowly and rhythmically.
C. Cardiac Muscle
Cardiac muscle, found in the walls of the heart, is also under control of the autonomic nervous
system. The cardiac muscle cell has one central nucleus, like smooth muscle, but it also is
striated, like skeletal muscle. The cardiac muscle cell is rectangular in shape. The contraction
of cardiac muscle is involuntary, strong, and rhythmical.
22
What’s More
Have you enjoyed learning about sensory mechanisms and skeletal and muscular systems?
Study the picture below. Explain how bats use echolocation in order to have a “vision” of their
surroundings.
23
What I Have Learned
2. If you are in a dark room, why is it that you don’t see any colors? What cells are active in
the dark?
________________________________________________________________________
________________________________________________________________________
What I Can Do
Humans have evolved through time with body modifications sufficient for the
survival of the race. We might not have sharp claws and teeth nor overwhelming muscles to
completely dominate every animal in the world. But still, we were able to be on top of the food
chain.
In your opinion, is it acceptable to artificially acquire body modifications in order to make the
human race adapt and maintain being the apex predator?
24
Assessment
25
8. What are the two types of light-sensitive cells which are contained in the retina?
A. Spheres and oblates
B. Pyramids and cubes
C. Rods and cones
D. Dodecahedrons and double helices
9. Which part of the ear is responsible for capturing sound and moving it into your ear?
A. Outer ear
B. Inner ear
C. Middle ear
D. Eardrum
10. The hearing organ is located at what part of the ear?
A. Outer ear
B. Inner ear
C. Middle ear
D. Cochlea
11. Crustaceans developed ________ type of skeleton.
A. Hydrostatic skeleton
B. Exoskeleton
C. Endoskeleton
D. Aquatic skeleton
12. Humans have ________ type of skeleton.
A. Hydrostatic skeleton
B. Exoskeleton
C. Endoskeleton
D. Hardened Skeleton
13. The wall of the heart is lined with ______ muscle.
A. Cardiac muscle
B. Smooth muscle
C. Skeletal muscle
D. Strong muscle
14. Smooth muscles are ______ muscles.
A. Voluntary
B. Involuntary
C. Sedative
D. Complete
15. Gastrointestinal tract is lined with _______ muscles.
A. Cardiac muscle
B. Smooth muscle
C. Skeletal muscle
D. Strong muscle
26
Additional Activities
You did a great job on reaching at this far end of this module! Let’s wrap up with another exciting
activity. Draw your representation of the human eye and write why it is an important sense organ for
the body.
27
28
What I Know
1. A sensory receptor
that responds to
light.
2. A sensory receptor Assessment
that responds to
physical stimuli. 1. B
3. A sensory receptor 2. D
that responds to 3. C
chemical stimuli. 4. A
What I Have Learned 5. B
4. A sensory receptor
that responds to 1. Locomotion plays a 6. C
temperature significant role in the 7. A
changes. survival of species in the 8. C
5. A sensory receptor animal kingdom. Many 9. A
that responds to animals rely on swift 10. C
tissue changes. locomotion to hunt and to 11. B
protect themselves from 12. C
being hunted, 13. A
2. Rod cells are in active 14. A
What’s More once there is no light 15. B
available in the
1. Bats utilizes their sense of surroundings. During this
hearing to have a time cone cells which are
visualization of their responsible for color
surroundings. Bats emit high perception cannot be
pitch sound and waits for it to activated.
bounce back from the What’s New
surroundings having a field
of view of what is in front of 1. Sense / Sensory
them.
Answer Key
References
Audesirk, T, Audesirk G and Byers DE. 2002. Biology. Life on Earth. (6th edition). Prentice-Hall,
Inc. 892 p.
Campbell, N, Mitchell L and Reece J. Biology. Concepts and Connections. (3rd edition). Addison
Wesley Longman. 809 p.
Immunology textbooks (e.g., Coico, Richard and Geoffrey Sunshine. Immunology: A Short
Course (Coico, Immunology) 7th Edition. 2015. Wiley-Blackwell)
Reece, JB, Urry LA, Wasserman SA, Minorsky PV and Jackson RB. 2011. Campbell’s Biology. (10
edition). Benjamin Cummings. 1488 pp.
29
This material was contextualized and localized by the
Learning Resource Management and Development Section (LRMDS)
SCHOOLS DIVISION OF SAN JOSE DEL MONTE
ESPERANZA D. ESPAÑOLA
Education Program Supervisor, Science
MELINDA F. OJEDA
CSJDM National Science High School
Language Reviewer
ROMELYN T. ASIS
CSJDM National Science High School – Senior High Content Language Editor
San Ignacio Street, Poblacion, City of San Jose Del Monte, Bulacan
30