Schizophrenia
Schizophrenia
Schizophrenia
2
CONTENT OVERVIEW/ INTRODUCTION
• Classification: ICD10
• Etiology, psycho-pharmacology, types, clinical
manifestations, diagnosis
• Nursing assessment: History, physical & mental status
assessment
• Treatment modalities & nursing management of patients
with schizophrenia and other psychotic disorders
• Geriatric considerations
• Follow-up , home care and rehabilitation
INTRODUCTION TO SCHIZOPHRENIA
3
Cont…..
5
DEFINITION
10
ETIOLOGY
11
ETIOLOGY – GENETICS
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Genetics (cont’d)
14
Biochemical Factors
Dopamine hypotheses: This theory suggests
that an excess of dopamine-dependent
neuronal activity in the brain may cause
schizophrenia.
Other biochemical hypotheses: Various other
biochemicals have been implicated in the
predisposition to schizophrenia. These include
abnormalities in the neurotransmitters
norepinephrine, serotonin, acetylcholine and
gamma-aminobutyric acid (GABA), and neuro-
regulators such as prostaglandins and
endorphins.
PSYCHOLOGICAL FACTORS
Family relationships act as major influence in the
development of illness:
• Mother-child relationship: Early theorists
characterized the mothers of schizophrenics as
cold, over-protective, and domineering, thus
retarding the ego development of the child.
• Dysfunctional family system: Hostility
between parents can lead to a schizophrenic
daughter (marital skew and schism).
• Double-bind communication (Bateson et al,
1956): Parents convey two or more conflicting
and incompatible messages at the same time. 25
SOCIAL FACTORS
Living in an urban environment has been
consistently found to be a risk factor for
schizophrenia. Social disadvantage found to be a
risk factor, include:
• Poverty,
• Migration related to social adversity,
• Racial discrimination,
• Family dysfunction,
• Unemployment
• Poor housing
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RISK FACTORS
Certain factors seem to increase the risk of developing or
triggering schizophrenia, including:
•Having a family history of schizophrenia
•Exposure to viruses, toxins or malnutrition while in the
womb, particularly in the first and second trimesters
•Stressful life circumstances
•Older paternal age
•Taking psychoactive drugs during adolescence and
young adulthood
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PHASES IN COURSE OF SCHIZOPHRENIA
1. Acute Phase
– Positive Symptoms And Negative
Symptoms
2. Maintenance Phase
– Acute Symptoms Are Less Severe
3. Stabilization Phase
– Remission Of Symptoms
Potential Early Symptoms: Pre-psychotic
• Withdrawal
• Depressed/Anxious
• Phobias
• Obsessions And Compulsions
• Difficulty Concentrating
• Preoccupation With Religion,
Self
• Dissociative Symptoms
SIGNS AND SYMPTOMS OF SCHIZOPHRENIA
CLINICAL FEATURES
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EUGENE BLEULER (1857-1939)
1. Affective disturbance
2. Autistic thinking
3. Ambivalence
4. Associative looseness
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KURT SCHNEIDER IN 1959
1. Thought echo
2. Auditory hallucination
3. Thought withdrawal
4. Thought insertion
5. Thought broadcasting
6. Delusional perception
7. Somatic passivity
8. Made volition
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SYMPTOMS OF SCHIZOPHRENIA
• Associative Looseness
• Neologisms
• Echolalia
• Clang Association
• Word Salad
Positive Symptoms:
Alterations In Perception
• Affective Blunting
• Anergia
• Anhedonia
• Avolition
• Poverty Of Content Of Speech
• Thought Blocking
• Flat Affect/Inappropriate Affect
Cognitive Symptoms
• Dysphoria
• Suicidal Ideation
• Hopelessness
OTHER FEATURES
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