EBM1
EBM1
EBM1
choice for hypercholesterolemia in this subset were no significant effects on triglycerides. Long
of the population, especially simvastatin and term treatment with garlic is more effective in
atrovastatin. reducing serum total cholesterol levels and serum
triglycerides (TG) levels.27 In present study hdl-
Simvastatin is an inhibitor of HMG-CoA reductase cholesterol concentration significantly increase
in the cholesterol synthesis.23 As none of the in addition to decrease in serum total cholesterol
anti-hyperlipidemic agents are devoid of adverse and LDL cholesterol concentration observed
effects, harmful efficient and cost effective agent after 8 weeks treatment of allium sativum. Similar
for managing hyperlipidemia. Therefore the use anti-hyperlipidemic effects of garlic also reported
of plant based herbal medicines have increased previously.28 decreased in total cholesterol
considerably over centuries and are becoming a concentration observed with allium sativum is
popular alternative management option.24 Allium because of decrease in LDL - cholesterol which
sativum based herbal medicine has proved to is due to blockage of biosynthesis of hepatic
decrease many disorders.25 Allium sativum and cholesterol possibly via inhibition of hydroxyl
simvastatin are lipid lowering agents. Allium methylglutaryl coa (HMG-CoA) reductase by
sativum is used around the worldwide. Its allicin, an organo-sulfur constituent of garlic.29
beneficial effects on cardiovascular risk factors
are widely known but have not been evaluated yet CONCLUSION
especially in Pakistan. In present study effect of Present study was designed to compare the
simvastatin on different biochemical parameters anti-lipidemic effect of allium sativum, a herbal
along with their lipid lowering efficacy is compare product, with a standard lipid lowering drug,
with the effects of allium sativum in diabetic simvastatin. Allium sativum improves lipid profile in
dyslipidemic patients. diabetic dyslipidemic patients without producing
adverse effects as compare to simvastatin and its
In present study when diabetic dyslipidemic beneficial effects on cardiovascular risk factors
patients were treated with product of simvastatin, are widely known but have not been evaluated
their serum cholesterol, triglyceride and low yet specially in Pakistan.
density lipoprotein (LDL) were significantly Copyright© 15 Oct, 2019.
decreased while significant increased has been
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5 Ayesha Ayaz