RESOURCES: USEFUL MEDICATIONS

Useful Medications for Oral Conditions*

DISCLAIMER: Drug information is constantly changing and is often subject to interpretation. While care has been taken to ensure
the accuracy of the information presented, the American Academy of Pediatric Dentistry is not responsible for the continued currency of
the information, errors, omissions, or consequences resulting from the use of these medications. Decisions about drug therapy must be based
upon the independent judgment of the clinician, changing drug information, and evolving healthcare practices.
* Pediatric dosage should not exceed adult dosage.

Analgesics
Mild/Moderate Pain1
Acetaminophen
Important: Both acute and chronic doses of acetaminophen are associated with hepatotoxicity. For this reason, this drug has been reformulated
so the products are limited to 325 mg per dosage unit.
Forms: Liquid, tablet, oral disintegrating tablet, caplet, rectal suppository, injectable
Usual oral dosage:2-5
Children < 12 years: 10-15 mg/kg/dose every 4-6 hours as needed (maximum daily dose 75 mg/kg, but not to exceed 4,000 mg/24 hours)

OR ALTERNATIVE DOSING BASED ON AGE OF CHILD3

Age Weight Dosage
lbs kg mg 3
0-3 months 6-11 2.7-5.3 40
4-11 months 12-17 5.4-8.1 80
1-2 years 18-23 8.2-10.8 120
2-3 years 24-35 10.9-16.3 160
4-5 years 36-47 16.4-21.7 240
6-8 years 48-59 21.8-27.2 320-325
9-10 years 60-71 27.3-32.6 325-400
11 years 72-95 32.7 - 43.2 480-500

Children > 12 years and adults: 325-650 mg every 4-6 hours

OR 1,000 mg 3-4 times daily as needed (maximum daily dose 4,000 mg)

Ibuprofen
Forms: Liquid, tablet, injectable
Usual oral dosage:2-5
Infants and children < 12 years: 4-10 mg/kg/dose every 6-8 hours as needed (maximum single dose 400 mg)

OR ALTERNATIVE DOSING BASED ON AGE OF CHILD 3

Age Weight Dosage
lbs kg mg
6-11 months 12-17 5.4-8.1 50
12-23 months 18-23 8.2-10.8 75-80
2-3 years 24-35 10.9-16.3 100
4-5 years 36-47 16.4-21.7 150
6-8 years 48-59 21.8-27.2 200
9-10 years 60-71 27.3-32.6 200-250
11 years 72-95 32.7 - 43.2 300

Children > 12 years: 200-400 mg every 4-6 hours as needed (maximum daily dose 3,200)
Adults: 200-400 mg/dose every 4-6 hours as needed
OR 600-800 mg every 6-8 hours as needed (maximum daily dose 3,200)

628 THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY

 RESOURCES: USEFUL MEDICATIONS

Naproxen
Important: Dosage expressed as 200 mg naproxen base is equivalent to 220 mg naproxen sodium. For acute pain, naproxen sodium may be
preferred because of increased solubility leading to faster onset, higher peak concentration, and decreased adverse drug events.4
Forms: Suspension, tablet
Usual dosage:2-5
Children and adolescents: 5-7 mg/kg every 8-12 hours as needed (maximum daily dose 1,000 mg)
Adults: Initial dose of 500 mg, then 250-500 mg every 12 hours
OR 250 mg every 6-8 hours as needed (maximum daily dose 1,250 mg on day 1, then 1,000 mg/day thereafter)

Moderate/Severe Pain
Important: The use of codeine and its alternatives, oxycodone, hydrocodone, morphine, and tramadol, for children as an analgesic is not
recommended by the American Academy of Pediatrics.6 An overview of the benefits and risks of analgesic medications for the management of
acute dental pain has been summarized.7

Systemic Antibiotics
Amoxicillin
Forms: Suspension, chewable tablet, tablet, capsule
Usual oral dosage:2-5
Infants > 3 months, children, and adolescents < 40 kg: 20-40 mg/kg/day in divided doses every 8 hours (maximum single dose 500 mg)
OR 25-45 mg/kg/day in divided doses every 12 hours (maximum single dose 875 mg)
Adolescents and adults: 250-500 mg every 8 hours
OR 500-875 mg every 12 hours
Endocarditis prophylaxis:3,4,8
Infants, children, and adolescents: 50 mg/kg (maximum single dose 2,000 mg) 30-60 minutes before procedure
Adults: 2,000 mg 30-60 minutes before procedure
Periodontal disease treatment for select cases using oral regimen combination of amoxicillin and metronidazole 9
Children and adolescents: Amoxicillin: 25-35 mg/kg/day in divided doses every 8 hours for 7 days (maximum single dose 500 mg)
AND Metronidazole: 10 mg/kg/dose every 8 hours for 7 days (maximum single dose 250 mg)
Adults: Amoxicillin: 375-500 mg every 8 hours for 7 days
AND Metronidazole: 250 mg every 8 hours for 7 days
Caution: For individuals who are allergic to penicillin, see alternative regimens under azithromycin and metronidazole

Amoxicillin clavulanate potassium

Important: Use the lowest dose of clavulanate combined with amoxicillin available to decrease gastrointestinal adverse drug events. The
frequency of dosing is generally based on the ratio of amoxicillin to clavulanate.4
Forms: Suspension, chewable tablet, tablet
Usual oral dosage:2-5 (based on amoxicillin component):
Children > 3 months of age up to 40 kg: 25-45 mg/kg/day in doses divided every 12 hours (maximum single dose 875 mg;
maximum daily dose 1,750 mg) (prescribe suspension or chewable tablet due to clavulanic
acid component)
Children > 40 kg and adults: 500-875 mg every 12 hours (prescribe tablet)
Examples of formulations and dosing schedule:3,4
4:1 formulations are dosed 3 times daily (amoxicillin 125 mg/clavulanate 31.25 mg; amoxicillin 250 mg/clavulanate 62.5 mg;
amoxicillin 500 mg/clavulanate 125 mg)
7:1 formulations are dosed 2 times daily (amoxicillin 200 mg/clavulanate 28.5 mg; amoxicillin 400 mg/clavulanate 57 mg;
amoxicillin 875 mg/clavulanate 125 mg)

Useful Medications continued on the next page.

THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY 629

RESOURCES: USEFUL MEDICATIONS

Azithromycin
Important: Doses may vary for extended release suspension depending on the reason for prescribing the antibiotic.
This drug is an option for patients with Type I allergy to penicillin and/or cephalosporin antibiotics.
Caution: This drug can cause cardiac arrhythmias in patients with pre-existing cardiac conduction defects.3,4
Forms: Tablet, capsule, suspension, injectable
Usual oral dosage:2-5
Children > 6 months up to 16 years: 10-12 mg/kg on day 1, single dose, (maximum 500 mg), followed by 5-6 mg/kg once daily
for remainder of treatment (2-5 days)
Adults: 500 mg on day 1, single dose, followed by 250 mg daily as a single dose (maximum 250 mg) for 2-5 days
Endocarditis prophylaxis:3-5,8
Infants, children, and adolescents: 15 mg/kg (maximum single dose 500 mg) 30-60 minutes before procedure
Adults: 500 mg 30-60 minutes before the procedures
Periodontal disease treatment for select cases using oral regimen of azithromycin only, when allergic to penicillin 9
Children and adolescents: 10-12 mg/kg once daily for 3 days (maximum daily dose 500 mg)
Adults: 500 mg once daily for 3 days (maximum daily dose 500 mg/day)

Cephalexin
Caution: This antibiotic should not be used by an individual who has a history of anaphylaxis, angioedema, or urticaria with penicillin
or ampicillin.3-5
Forms: Suspension, tablet, capsule
Usual oral dosage:2-5
Infants, children and adolescents: Mild to moderate infections: 25-50 mg/kg/day divided every 6-12 hours
(maximum daily dose 2,000 mg)
Severe infections: 75-100 mg/kg/day divided every 6-8 hours
(maximum daily dose 4,000 mg)
OR 500 mg every 12 hours
Adults: 250-1,000 mg every 6 hours (maximum daily dose 4,000 mg)
Endocarditis prophylaxis:3,4,8
Infants, children, and adolescents: 50 mg/kg (maximum single dose 2,000 mg) 30-60 minutes before procedure
Adults: 2,000 mg 30-60 minutes before procedure

Clarithromycin
Important: This drug is an option for patients with Type I allergy to penicillin and/or cephalosporin antibiotics.
Caution: This drug can cause cardiac arrhythmias in patients with pre-existing cardiac conduction defects.3,4
Forms: Suspension, tablet
Usual oral dosage:2-5
Infants, children and adolescents: 15 mg/kg/day divided every 12 hours (maximum single dose 500 mg)
Adults: 500 mg every 12 hours
Endocarditis prophylaxis:3,4,8
Infants, children and adolescents: 15 mg/kg (maximum single dose 500 mg) 30-60 minutes before procedure
Adults: 500 mg 30-60 minutes before procedure

Clindamycin
Important: This is an option for patients with Type I allergy to penicillin and/or cephalosporin antibiotics. This antibiotic is effective
for infections (e.g., abscesses) with gram-positive aerobic bacteria and gram-positive or gram-negative anaerobic bacteria. However,
Clostridioides difficile colitis is a serious adverse reaction with this antibiotic.3-5
This antibiotic is no longer recommended for endocarditis prophylaxis for dental procedures.8
Forms: Suspension, capsule, injectable
Usual oral dosage:2-5
Infants, children and adolescents: 10-25 mg/kg/day in divided doses every 8 hours (maximum single dose 450 mg)
Adults: 300-450 mg every 6-8 hours (maximum daily dose 1,800 mg)

630 THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY

 RESOURCES: USEFUL MEDICATIONS

Doxycycline
Important: Tetracycline may cause permanent tooth discoloration, enamel hypoplasia in developing teeth, and hyperpigmentation of the soft
tissues. Due to these side effects, this drug usually is not recommended for women who are pregnant and children < 8 years old. However,
short-term use of doxycycline (< 21 days) is recommended by the American Academy of Pediatrics for specific infections when necessary
because there is lack of clinical evidence that this form of tetracycline results in discoloration of developing teeth when used for < 21 days.3,4,10
Forms: Suspension, tablet, delayed release tablet, capsule, injectable
Usual oral dosage:2-5
Children > 8 years and adolescents: 2.2 mg/kg/dose every 12 hours (maximum single dose 100 mg/dose)
Adults: 100 to 200 mg/day once a day or divided 2 times daily every 12 hours
Endocarditis prophylaxis:3,4,8
Children > 8 years and adolescents: children < 45 kg, 2.2 mg/kg
children > 45 kg, 100 mg 30-60 minutes before procedure
Adults: 100 mg 30-60 minutes before the procedure

Metronidazole
Important: Metronidazole is a useful addition to an antibiotic regimen when coverage of anaerobic bacteria is needed. Patients should
avoid ingestion of alcohol as a beverage or ingredient in medications or propylene glycol-containing products while taking metronidazole.
There is a warning with the drug because it has been shown to be carcinogenic in mice and rats.3.4
Forms: Tablet, tablet extended release, capsule, injectable
Usual oral dosage:
For anaerobic skin and bone infection:3-5
Children and adolescents: 15-50 mg/kg/day in divided doses 3 times daily (maximum daily dose 2,250 mg)
Adults: 7.5 mg/kg every 6 hours (maximum daily dose 4,000 mg)
For periodontal disease, including necrotizing gingivitis:4,5,9
Children and adolescents who are allergic to penicillin: 10 mg/kg/dose every 8 hours for 7 days (maximum single dose 250 mg)
Adults who are allergic to penicillin: 250-500 mg every 8 hours for 7 days
See amoxicillin and azithromycin above for other periodontal treatment approaches.

Penicillin V Potassium
Important: Anaphylactic reactions have been demonstrated in patients receiving penicillin, most notably those with a history of beta-lactam
hypersensitivity, sensitivity to multiple allergens, or prior IgE-mediated reactions (e.g., angioedema, urticaria, anaphylaxis).3
Forms: Liquid, tablet
Usual oral dosage:2-5
Children and adolescents: 25-50 mg/kg/day in divided doses every 6 hours (maximum daily dose 2,000 mg)
Adults: 250-500 mg every 6-8 hours

Topical Antibacterial/Antimicrobial Agents

Chlorhexidine gluconate
Important: Most brands contain alcohol.
Forms: Dental solution 0.12% (118 mL, 473 mL)
Usual dosage for gingivitis/periodontitis and stomatitis (off label use for stomatitis):2-5
Children ≥ 8 years and adults: Rinse with 15 mL 2 times daily (after breakfast and before bed) for 30 seconds and expectorate.

Mupirocin
Important: For external use only; not for use in patients < 2 months of age.
Forms: Ointment 2%; cream 2%
Usual dosage for localized impetigo or skin infection:2-5
Children and adults: Apply a small amount of ointment to the affected area 3 times daily for 5-10 days. If no clinical response after
5 days, then reevaluate.

Useful Medications continued on the next page.

THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY 631

RESOURCES: USEFUL MEDICATIONS

Retapamulin
Important: For external use only; limited information on age group < 9 months of age.
Forms: Ointment 1%
Usual dosage for localized impetigo:2-5
Children and adults: Apply a small amount of ointment to the affected area 2 times daily for 5 days.

Antifungal Agents for Candidiasis

Systemic antifungal agent for oral candidiasis
Fluconazole
Important: The drug requires acidic pH in the stomach to disintegrate and dissolve for oral absorption; therefore, absorption is decreased by
medications that increase gastric pH. Also, prescribe with caution for patients taking other medications metabolized by CYP enzymes because
fluconazole is a hepatic enzyme inhibitor.3,4
Form: Suspension 10 mg/mL, 40 mg/mL; tablet: 50 mg, 100 mg, 150 mg, 200 mg; injectable: 100mg/50 mL, 200 mg/100 mL,
400 mg/200 mL.
Usual dosage:2-5
Infants, children and adolescents: Single dose of 6-12 mg/kg/dose followed by 3 mg/kg/dose once daily for 7-14 days
(maximum single dose 400 mg)
Adults: Single dose of 200 mg on day 1, then 100-200 mg/dose once daily for 7-14 days

Topical or transmucosal agents for oral candidiasis

Clotrimazole
Important: This drug is not for use in patients < 3 years of age.
Form: Lozenge 10 mg
Usual dosage:2-5
Children > 3 years and adults: Dissolve 1 lozenge 5 times daily for 7-14 days. Treatment may extend beyond clinical resolution.

Miconazole
Important: This dosage form contains milk protein concentrate.
Form: Buccal tablet 50 mg
Usual dosage:3,4
Adolescents >13 years and adults: 1 tablet daily for 14 days; apply to the gum region, just above the upper lateral incisor.

Nystatin
Form: Suspension (100,000 units/mL)
Usual oral dosage:3,4,10
Infants: 200,000 units (2 mL) 4 times daily; ½ of dose placed in each side of mouth. Use for 7-14 days.
Children and adults: Swish 400,000-600,000 units (4-6 mL) 4 times daily for several minutes and swallow; continue at least 48 hours
after symptoms resolve. Use for 7-14 days.

Topical agents for angular cheilitis

Clotrimazole
Form: Cream 1%
Usual dosage:4,11
All ages: Apply a thin layer to the corners of the mouth 2-4 times daily for 7-14 days or until complete healing.

Miconazole nitrate
Forms: Ointment 2%; cream 2%
Usual dosage:4,11
Children > 2 years and adults: Apply a thin layer to the corners of the mouth 2-4 times daily for 7-14 days or until complete healing.

632 THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY

 RESOURCES: USEFUL MEDICATIONS

Nystatin
Forms: Ointment, cream (100,000 units/g)
Usual dosage:2,4,11
For all ages: Apply a thin layer to corners of mouth 2-4 times daily for 7-14 days or until complete healing.

Nystatin, triamcinolone acetonide (not Food and Drug Administration [FDA]-approved for this use)
Forms: Ointment, cream (100,000 units nystatin/g and 0.1% triamcinolone acetonide)
Usual dosage:4,11
All ages > 2 months: Apply a thin layer to the corners of the mouth 2 times daily for no longer than 2 weeks. Should be used for the
shortest period of time in children (3-5 days).

Antiviral Agents
Systemic agent for primary herpetic gingivostomatitis
Acyclovir (not FDA-approved for this use)
Forms: Suspension 200 mg/5 mL; tablets 400 mg, 800 mg; capsules 200 mg; injectable 50 mg/mL
Usual dosage:3-5
Infants, children and adolescents: 20 mg/kg/dose 4 times daily for 5-7 days (maximum single dose 800 mg)
Immunocompromized children: 20 mg/kg/doses 4 times daily for 7-10 days
Immunocompromized adolescents: 400 mg 3 times daily for 5-10 days or until resolution
Adults: 400 mg 3-5 times daily for 5-10 days

Valacyclovir (not FDA-approved for this use)

Forms: Suspension may be compounded by pharmacist; tablets 500 mg, 1,000 mg
Usual dosage:3-5
Infants ≥ 3 months, children and adolescents: 20 mg/kg/dose 2 times daily for 5-7 days (maximum single dose 1,000 mg)
Immunocompromised children and adolescents: 20 mg/kg/dose 2 times daily for 10-14 days
Adults: 1,000 mg 2 times daily for 7-10 days

Systemic agents for herpes labialis

Acyclovir (not FDA-approved for this use)
Form: Suspension 200 mg/5 mL; tablets 400 mg, 800 mg; capsules 200 mg; injectable 50 mg/mL
Usual dosage:2-5 (Begin treatment at the earliest signs/symptoms)
Infants and children: 20 mg/kg/dose 4 times daily for 7-10 days or until clinical resolution (maximum single dose 400 mg)
Immunocompromised children: 20 mg/kg/dose 4 times daily for 7-10 days or until clinical resolution
Adolescents and adults: 400 mg 3 times daily for 5-10 days or until clinical resolution

Famciclovir
Form: Tablet 125 mg, 250 mg, 500 mg
Usual dosage: 2-5
Children and adolescents: Safety and efficacy have not been established.
Adolescents and adults: 1,500 mg as a single dose at the first sign or symptom of infection (maximum dose has not been established
for adolescents; maximum daily dose 2,000 mg for adults for one-day regimens or 1,500 mg/ day orally for
multiple-day regimens)
Immunocompromised adolescents and adults: 500 mg 2 times daily for 5-10 days

Valacyclovir
Form: Tablet 500 mg, 1,000 mg
Usual oral dosage:2-5
Children ≥ 12 years and adults: 2,000 mg every 12 hours for 1 day (2 doses); initiate at first signs or symptoms of infection
(maximum daily dose 4,000 mg for one-day regimen)
Immunocompromised adolescents and adults: 1,000 mg every 12 hours for 5-10 days (maximum daily dose 3,000 mg)

THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY 633

RESOURCES: USEFUL MEDICATIONS

Topical agents for herpes labialis

Docosanol
Form: Cream 10%
Usual dosage:2-5
Children ≥ 12 years and adults: Apply a thin layer on the lesion 5 times daily for up to 10 days.

Acyclovir
Form: Cream 5%
Usual dosage:3-5
Children ≥ 12 years and adults: Apply a thin layer on the lesion 5 times daily for 4 days.

Acyclovir (minimal transmucosal absorption)

Important: This dosage form contains milk protein concentrate.
Form: Buccal tablet 50 mg
Usual dosage:3-5
Children ≥ 12 years and adults: Apply 1 tablet 1 time to the upper gums in area of canine fossa.

Acyclovir with hydrocortisone

Form: Cream (5% acyclovir with 1% hydrocortisone)
Usual dosage:3-5
Children ≥ 6 years and adults: Apply a thin layer on the lesion 5 times daily for 5 days.

Penciclovir
Form: Cream 1%
Usual dosage:2-5
Children ≥ 12 years and adults: Apply a thin layer on the lesion every 2 hours while awake for 4 days.

Topical Corticosteroids
Use for noninfectious ulcers and mucocutaneous lesions, including aphthous ulcers, localized contact allergic reactions, and symptomatic
benign migratory glossitis.

Triamcinolone acetonide (medium potency corticosteroid)

Form: Dental paste or ointment 0.1%
Usual dosage:3,4,11
Children, adolescents and adults: Apply paste to ulcers 2-4 times daily, after meals and at bedtime; not to exceed 14 day course.
Avoid eating or drinking for 30 minutes after application

Fluocinonide (high potency corticosteroid; not FDA-approved for oral application)

Form: Gel, ointment 0.05%
Usual dosage:4,11
Adolescents and adults: Apply thin amount of gel or ointment to ulcers 2-4 times daily; not to exceed 14 day course.

Dexamethasone (high potency corticosteroid; not FDA-approved for oral application)

Form: Elixir, solution 0.5 mg/5 mL (contains alcohol)
Usual dosage:11
Adolescents and adults: Rinse with 5 mL 2-4 times daily for 2 minutes and expectorate; not to exceed 14 day course.

Clobetasol (super-high potency corticosteroid; not FDA-approved for oral application)

Form: Gel, ointment 0.05%
Usual dosage:4,11
Adolescents and adults: Apply thin amount of gel or ointment to ulcers 2-4 times daily, not to exceed 14 day course.

634 THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY

 RESOURCES: USEFUL MEDICATIONS

References
1. American Academy of Pediatric Dentistry. Policy on pediatric dental pain management. The Reference Manual of
Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2022:139-41.
2. Jeske AH. Mosby’s Dental Drug Reference. 13th ed. St. Louis, Mo.: Elsevier, Inc.; 2022.
3. Lexicomp Online, Pediatric and Neonatal Lexi-Drugs Online. Hudson, Ohio: Wolters Kluver Clinical Drug Information,
Inc.; 2022. Available at: “http://webstore.lexi.com/Pediatric-Lexi-Drugs”. Accessed September 25, 2022.
4. Lexicomp Online, Lexi-Drugs Online. Hudson, Ohio: Wolters Kluver Clinical Drug Information, Inc.; 2022. Available
at: “http://www.wolterskluwercdi.com/lexicomp-online/”. Accessed September 25, 2022.
5. ClinicalKey Online, Gold Standard Drug Monographs Online. North America: Elsevier, Inc.; 2022. Available at: “http://
www.clinicalkey.com/#!/content/drug_monograph/”. Accessed September 25, 2022.
6. Tobias JD, Green TP, Coté CJ, Section on Anesthesiology and Pain Medicine, American Academy of Pediatrics Committee
on Drugs. Codeine: Time to say “no”. Pediatrics 2016;138(4):e20162396.
7. Moore PA, Ziegler KM, Lipman RD, et al. Benefits and harms associated with analgesic medications used in the
management of acute dental pain. An overview of systematic reviews. J Am Dent Assoc 2018;149(4):256-68.
8. Wilson WR, Gewitz M, Lockhart PB, et al. Prevention of viridans group streptococcal infective endocarditis. A scientific
statement from the American Heart Association. Circulation 2021;143(20):e963-e978. Epub 2021 Apr 15. Available
at: “https://www.ahajournals.org/doi/epub/10.1161/CIR.0000000000000969”. Erratum in: Circulation 2021;144(9):e192.
Available at: “https://www.ahajournals.org/doi/10.1161/CIR.0000000000001012”. Accessed September 19, 2022.
9. American Academy of Pediatric Dentistry. Risk assessment of periodontal diseases and pathologies in pediatric dental
patients. The Reference Manual of Pediatric Dentistry, Chicago, Ill.: American Academy of Pediatric Dentistry; 2022:
466-84.
10. Committee on Infectious Diseases, American Academy of Pediatrics. Antimicrobial agents and related therapy, Section 4.
In: Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH, eds. Red Book: 2021-2024 Report of the Committee on
Infectious Diseases. 32nd ed. Itasca, Ill.: American Academy of Pediatrics; 2021:863-1006.
11. Little JW, Miller CS, Rhodus NL. Dental Management of the Medically Compromised Patient. 9th ed. St. Louis, Mo.:
Elsevier, Inc.; 2018.

THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY 635