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INDEX
2.12 Merging of 3 Super-massive Black Holes ......... 35 4.19 Hypersonic Missiles .......................................... 54
2.13 Near-surface Shear Layer ................................ 36 4.20 MANPADS ........................................................ 55
2.14 Solar Storm & Internet ..................................... 37
Aircrafts ............................................... 55
2.15 Planet Nine ....................................................... 37
4.21 Black Box .......................................................... 55
2.16 Leonids Meteor Shower .................................... 37
4.22 Light Combat Aircraft Programme .................. 56
2.17 Proxima Centauri ............................................. 38
4.23 P-8I Aircraft ..................................................... 56
2.18 Detection of Dark Energy ................................. 38
4.24 Advanced Light Helicopter MK III ................... 57
2.19 Fastest Spinning White Dwarf .......................... 39
2.20 Kamo’oalewa ................................................... 39 Drones .................................................. 57
2.21 Supermassive Black Hole & Gravity ................ 40 4.25 Kamikaze Drones.............................................. 57
2.22 Magnetar .......................................................... 40 4.26 HANSA-NG ....................................................... 57
2.23 Carbon Enhanced Metal-Poor Stars ................ 41
Submarines ........................................... 58
2.24 Binary Star ....................................................... 41
2.25 Solar Jets .......................................................... 42 4.27 India’s Submarine Strength .............................. 58
3.2 PASIPHAE ....................................................... 44 4.30 RoIP in Syama Prasad Mookerjee Port ............ 60
3.3 Hubble Telescope in Safe Mode ....................... 44 4.31 EW Suite Shakti ................................................ 61
3.4 James Webb Space Telescope .......................... 45 4.32 Coast Guard Ship ‘Sarthak’ ............................. 61
5.20 Additional Covid-19 Vaccine and Booster Shot - 5.60 Silicosis ............................................................. 90
Difference ..................................................................... 71
5.61 Wolbachia Mosquitoes ..................................... 91
5.21 Pseudoephedrine .............................................. 72
5.62 Muscle Dysfunction and Vitamin D .................. 91
5.22 Intranasal Covid-19 Vaccines .......................... 72
5.23 NeoCoV & Zoonotic Spillover .......................... 73 6. Bio-Technology ............................... 92
1. SPACE TECHNOLOGY
Introduction
A satellite in the polar orbit approx. takes 90 minutes for a full rotation. As a result, a satellite can observe the
entire surface in the time span of 24 hours.
They are often used for applications such as monitoring crops, forests and even global security.
Sun Synchronous Orbit –It is a special case of Polar Orbit moving from pole to pole allowing satellite to pass
over any given point of the planet's surface at roughly the same local time each day.
Since there are 365 days in a year and 360 degrees in a circle, it means that the satellite has to shift its orbit by
approximately one degree per day.
These orbits are used for satellites that need a constant amount of sunlight and are useful for imaging, spy, and
weather satellites.
1.4 PSLV
It is the3rd generation launch vehicle and first Indian launch vehicle to be equipped with liquid stages.
PSLV emerged as the reliable and versatile workhorse launch vehicle of India with consecutively successful
missions.
It successfully launched two spacecraft such as Chandrayaan-1 in 2008 and Mars Orbiter Spacecraft in 2013.
3 variations in PSLV - PSLV-G (General), PSLV-XL variants and PSLV-CA (Core Alone).
It has 4 stages in its operation to provide thrust in launching spacecraft to different orbits.
Stage I: It uses solid rocket motor that is augmented by 6 solid strap-on boosters. Strap on boosters are used
only in G and XL variation.
Stage II: It uses an Earth storable liquid rocket engine, known as the Vikas engine.
Stage III: It uses solid rocket motor that provides high thrust after the atmospheric phase of the launch.
Stage IV: It comprises two Earth storable liquid engines.
Capacity - 1,750 kg of payload to Sun-Synchronous Polar Orbits of 600 km altitude and to 1,425 kg of payload
to Geosynchronous and Geostationary orbits, like satellites from the IRNSS constellation.
PSLV launches– PSLV-C48/RISAT-2BR1, PSLV-C47 / Cartosat-3, PSLV-C46/RISAT-2B, PSLV-
C45/EMISAT MISSION, PSLV - C44/Microsat, Kalamsat etc
1.5 GSLV
It is the 4th generation launch vehicle, a three-stage vehicle with four liquid strap-on boosters.
GSLV Mk II is the largest launch vehicle developed by India, which is currently in operation.
1. Stage I: It uses solid rocket motor with 4 liquid strap-ons.
2. Stage II: It uses liquid rocket engine (similar to vikas engine of PSLV stage II).
3. Stage III: It uses India’s first cryogenic engine (CE-7.5) in the upper stage. It enabled the launching of
2000 kg of communication satellites.
Capacity - It can take up to 5000 kg of pay load to Low Earth Orbits, 2500 kg of payload to Geosynchronous
Transfer Orbit (GTO) which are primarily INSAT class of communication satellites.
GSLV Launches – GSLV – F11/GSAT-7A and GSLV – F08/GSAT – 6A mission.
The next variant of GSLV is GSLV Mk III, with indigenous high thrust cryogenic engine.
1.7 RLV-TD
Reusable Launch Vehicle – Technology Demonstrator (RLV-TD) is a fully reusable launch vehicle to enable low
cost access to space.
The configuration of RLV-TD is similar to that of an aircraft and combines the complexity of both launch
vehicles and aircraft.
The winged RLV-TD has been configured to act as a flying test bed to evaluate various technologies, namely,
hypersonic flight, autonomous landing and powered cruise flight.
In future, this vehicle will be scaled up to become the first stage of India’s reusable two stage orbital launch
vehicle.
Objectives of RLV-TD - Hypersonic aero thermodynamic characterisation of wing body, Evaluation of
autonomous Navigation, Guidance and Control (NGC) schemes, Integrated flight management and Thermal
Protection System Evaluation
It was successfully flight tested in 2016 from Sriharikota.
It is aimed at improving the payload capability of PSLV, GSLV and GSLV Mk-III launch vehicles.
The Vikas Engine is the workhorse liquid rocket engine powering
o The second stage of India’s Polar Satellite Launch Vehicle (PSLV),
o The second stage and the four strap on stages of Geosynchronous Launch Vehicle (GSLV) and
o The twin engine core liquid stage (L110) of GSLV Mk-III.
ISRO has recently improved the thrust of the Vikas engine which is expected to boost the rocket engine.
The main beneficiary of the high-thrust Vikas engine is GSLV-Mark III launcher, which is expected to lift 4,000-
kg satellites to space.
GSLV-Mark III uses twin engine core liquid stage (L110).
GSLV – Mark III with upgraded Vikas engine would be the third Mk-III and the first working one to be
designated MkIII Mission-1 or M1.
ATV is a two- stage solid launch vehicle capable of carrying Scramjet engines weighed 3277 kg at lift-off.
India is the fourth country (after USA, Russia and European Space Agency) to demonstrate the flight testing of
a Scramjet Engine.
1.15 EOS-04
India’s Polar Satellite Launch Vehicle PSLV-C52 injected Earth Observation Satellite EOS-04, into an intended sun
synchronous polar orbit of 529 km altitude from Satish Dhawan Space Centre, SHAR, Sriharikota.
EOS-04 is a Radar Imaging Satellite designed to provide high quality images under all weather conditions for
applications such as Agriculture, Forestry & Plantations, Soil Moisture & Hydrology and Flood mapping.
PSLV-C52/EOS-04 has a mission life of 10 years.
The vehicle also placed two small co-passenger satellites,
1. A student satellite (INSPIREsat-1) from Indian Institute of Space Science & Technology (IIST) in
association with Laboratory of Atmospheric & Space Physics at University of Colorado, and
2. A technology demonstrator satellite (INS-2TD) from ISRO, which is a precursor to India-Bhutan Joint
Satellite (INS-2B).
1.17 SC120-LOX
Hindustan Aeronautics Ltd (HAL) has delivered the ‘heaviest’ Semi-Cryogenic propellant tank (SC120-LOX) to the
Indian Space Research Organisation (ISRO).
[In 2020, HAL had delivered the biggest ever cryogenic Liquid Hydrogen tank (C32-LH2) which is four metres
in diameter and eight metres in length, much ahead of contractual schedule.]
Semi cryo-liquid oxygen (LOX) tank - the first developmental welded hardware - is a part of the SC120 stage.
SC120 stage is intended for payload enhancement by replacing the L110 stage in the existing GSLV Mk-
III launch vehicle.
HAL, strategic reliable partner to ISRO, has delivered critical structures, tankages, satellite structures for
the PSLV, GSLV-Mk II and GSLV-Mk III launch vehicles since the last 5 decades.
SCE200
SCE200 (under development) is an Indian example of Semi-Cryogenic Engine.
This engine is expected to power ISRO’s upcoming Unified Launch Vehicle (ULV) and Reusable Launch Vehicle
(RLV).
Semi-Cryogenic Engine burns liquid oxygen (LOX) and RP-1 kerosene in an oxidizer-rich staged combustion
cycle.
[A cryogenic engine uses Liquid Oxygen and Liquid Hydrogen (LH2) as propellants.]
1.18 GSAT 7B
The Defence Acquisition Council (DAC) chaired by Defence Minister has given the Acceptance of Necessity (AoN) for
procuring a GSAT 7B satellite, along with equipment like Night Sight (image intensifier), etc.
Launched in 2013, the GSAT 7 series satellites are advanced satellites developed by the Indian Space Research
Organisation (ISRO).
They were developed to meet the communication needs of the defence services, which includes low bit
voice rate to high bit rate data facilities, including multi-band communications.
This satellite has a footprint of nearly 2,000 nautical miles in the Indian Ocean region.
Rukmini - Named Rukmini, the satellite is mainly used by the Indian Navy for its communication needs.
It carries payloads in UHF, C-band and Ku-band, and helps the Navy to have a secure, real time communication
link between its land establishments, surface ships, submarines and aircraft.
The satellite was injected into a geosynchronous transfer orbit (GTO).
Role of GSAT 7B - Currently, the Indian Army is using 30% of the communication capabilities of the GSAT
7A satellite, which has been designed for the Indian Air Force (IAF).
So, GSAT 7B will primarily fulfill the Army’s communication needs.
It will also help the Army enhance its surveillance in border areas.
GSAT 7A Satellite
Launched in 2018, GSAT 7A has gone a long way in boosting the connectivity between the ground radar stations,
airbases and the airborne early warning and control aircraft (AEW&C) of the IAF.
It also helps in satellite controlled operations of unmanned aerial vehicles (UAVs) which gives a great deal of
reliability to the operations as compared to ground controlled operations.
It has 10 channels in Ku band with switchable frequency for mobile users, a fixed Gregorian or parabolic
antenna, and 4 steerable antennae.
GSAT 7C Satellite
A GSAT 7C satellite is on the cards for the IAF, and a proposal to this effect was cleared by the DAC in 2021.
It would facilitate real time communication with IAF’s software defined radio communication sets.
It will increase the capability of the IAF to communicate beyond the line of sight in a secure mode.
Other Military Satellites of India
EMISAT - An Electromagnetic Intelligence Gathering Satellite (EMISAT), developed by ISRO, was launched
in 2020 through a Polar Satellite Launch Vehicle (PSLV-C45).
It is Indian reconnaissance satellite under Defence Research and Development Organisation (DRDO) project
Kautilyas.
Kautilya is an Electronic Intelligence (ELINT) package, which allows the interception of ground-based radar
and also carries out electronic surveillance across India.
It provides the capability in direction-finding of radar and fixing their locations.
Placed in a 748-km orbit, EMISAT is based on the Israeli satellite system.
It circles the globe pole-to-pole, and is helpful in gathering information from radars of countries that have
borders with India.
RISAT 2BR1 - Launched in 2019, RISAT 2BR1 is India’s synthetic aperture radar imaging satellite.
It has the capability to operate in different modes including very high resolution imaging modes of 1×0.5m
resolution and 0.5×0.3m resolution with a swath of 5-10 km.
1.19 Gaganyaan
Gaganyaan is the India’s first Human Space Flight Programme.
ISRO is targeting December, 2021 to launch the unmanned test mission of Gaganyaan project.
The programme will make India the fourth nation in the world to launch a Human Spaceflight Mission, only
after the USA, Russia and China.
It is being operating under a newly formed Centre, Human Space Flight Centre (HSFC).
It aims to send a three-member crew to space for a period of five to seven days.
ISRO has developed some critical technologies through demonstrations like Space Capsule Recovery
Experiment (SRE-2007), Crew module Atmospheric Reentry Experiment (CARE-2014) and Pad Abort Test
(2018).
The spacecraft will be placed in a low earth orbit of 300-400km.
GSLV Mk-III launch vehicle will be used to for the mission. It has the payload capacity of 4000 kg satellites in
Geosynchronous Transfer Orbit (GTO) and 8000 kg payload to Low Earth Orbit.
The crew will be selected by Indian Air Force (IAF) and ISRO jointly after which they will undergo training for
two-three years.
Re-entry & Recovery tech - ISRO has already tested the GSLV Mk-III with experimental crew module.
It came back to Earth after being taken to an altitude of 126 km into space. This this known as Crew module
Atmospheric Re-entry Experiment (CARE).
Crew Escape System – It is an emergency escape measure to quickly pull the astronaut crew out to a safe
distance from launch vehicle during a launch abort.
Pad Abort test was conducted earlier to demonstrate this to ascertain the efficiency of crew escape system.
Life support -The Environmental Control & Life Support System (ECLSS) is meant for humans inside to live
comfortably.
It ensures that conditions inside the crew module are suitable for living.
The ECLSS -
i. Maintains a steady cabin pressure and air composition
ii. Removes carbon dioxide and other harmful gases
iii. Controls temperature and humidity
iv. Manages parameters like fire detection and suppression, emergency support
v. Takes care of food and water management
Human Space Flight Centre - India’s world-class facility for training GAGANYAAN astronauts will be
established in three years at Challakere, Chitradurga district of Karnataka.
Challakere, is called the Science City, it houses facilities of the ISRO, the DRDO’s Advanced Aeronautical Test
Range, the Bhabha Atomic Research Centre and the Indian Institute of Science.
It will be the single-stop consolidating infrastructure and activities related to space travellers.
It will also host work related to crew and service modules of the spacecraft that carries the astronauts and up to
mission control.
It has detected signatures of the sub-surface water-ice and potential water ice at the poles.
Minor Elements - By measuring the Moon’s X-ray spectrum, Large Area Soft X-Ray Spectrometer (CLASS)
has detected the minor elements for the first time through remote sensing.
CLASS has detected sodium, chromium and manganese on the Moon.
Studying the Sun - Solar X-ray Monitor (XSM) payload studied the Moon through the radiation coming in
from the Sun.
XSM has also collected information about micro solar flares outside the active region for the first time.
CHACE-2 - CHandra's Atmospheric Compositional Explorer 2 (CHACE 2) is a quadrupole Mass spectrometer
on board Chandrayaan-2 mission.
It conducted first-ever in-situ study of the composition of the lunar neutral exosphere from a polar orbital
platform.
It detected and studied the variability of the Argon-40 at the middle and higher latitudes of the Moon, depicting
the radiogenic activities in the mid and higher latitudes of the Lunar interior.
Argon-40 (Ar-40), a noble gas is an inert, colorless and odourless element.
Ar-40 originates from the radioactive disintegration of Potassium-40 (K-40) present below the lunar surface.
[The production of argon-40 from potassium-40 decay is utilized as a means of determining Earth’s age
(potassium-argon dating).]
Once formed, Ar-40 diffuses through the inter-granular space and makes way up to the lunar exosphere through
seepages and faults.
Chandrayaan-3
Chandrayaan-3 is likely to be launched in 2022 (earlier scheduled to be launched in late 2020), which is India’s
third mission to Moon.
It aims to make a soft-landing in the Lunar South Pole’s Aitken basin.
It will consist of only a lander and rover, as the orbiter of Chandrayaan-2 is still functioning and providing data.
This vision algorithm detects the CMEs automatically in the outer corona where these eruptions cease to show
accelerations and propagate with a nearly constant speed.
However, this algorithm could not be applied to the inner corona observations due to the vast acceleration
experienced by these eruptions.
Aditya-L1 Support Cell (AL1SC), a community service centre, has been set up to bring all science data on
boardAditya-L1 to a single web-based interface. This will maximize utilization of data from Aditya-L1.
AL1SC is a joint effort of Indian Space Research Organisation (ISRO) and Aryabhatta Research Institute of
Observational Sciences (ARIES), an autonomous institute of the Department of Science & Technology.
It is set up at the transit campus of ARIES at Haldwani, Uttarakhand.
Lagrange Points
A Lagrange point is a location in space where the combined gravitational forces of two large bodies, such as
Earth and the sun or Earth and the moon, equal the centrifugal force felt by a much smaller third body.
The interaction of the forces creates a point of equilibrium where a spacecraft
may be "parked" to make observations.
The first point, L1, lies between Earth and the sun and gets an uninterrupted
view of the sun and free from the occurrence of eclipses.
L2 with the Earth, moon and sun behind it, a spacecraft can get a clear view
of deep space and it has a protection for radiation field from sun.
The James Webb Space Telescope will move into L2 point in 2018.
The third Lagrange point, L3, lies behind the sun, opposite Earth's orbit. For
now, science has not found a use for this spot.
Points L4 and L5 are stable and lie along Earth's orbit at 60 degrees ahead of and behind Earth and dust and
asteroids tend to accumulate in these regions due to its stability.
Asteroids that surround the L4 and L5points are called Trojans and Earth’s only known Trojan asteroid, 2010
TK7 is found in the region.
Global Missions
NASA
1.27 CIBER-2
A NASA-funded rocket will carry CIBER-2 instrument to count the number of stars that exist in the Universe.
The mission’s CIBER-2 instrument has been improved upon to see if any stars had been undercounted in the
previous counting attempts.
Estimation - In order to estimate the number of stars in the Universe, scientists have estimated that on average
each galaxy consists of about 100 million stars, but this figure is not exact (underestimation).
But this calculation assumes that all stars are inside galaxies - might not be true - and this is what the CIBER-2
instrument will try to find out.
Working - The CIBER-2 will launch aboard a suborbital sounding rocket that will carry scientific instruments
on brief trips into space before it falls back to Earth for recovery.
Once the instrument is above Earth’s atmosphere, it will survey a patch of sky that will include dozens of clusters
of galaxies.
Even so, the instrument will not actually count individual stars but it will instead detect the extragalactic
background light, which is all of the light that has been emitted throughout the history of the Universe.
From all of this extragalactic background light, the CIBER-2 will focus on a portion of the cosmic infrared
background, which is emitted by some of the most common stars.
This approach is aiming to look at how bright this light is to give scientists an estimate of how many of these
stars are out there.
Previously, the ESA infrared space observatory Herschel also counted the number of galaxies in infrared and
measured their luminosity.
1.28 Landsat 9
Earth Monitoring Satellite Landsat 9 - a joint mission of NASA and the US Geological Survey (USGS) - was launched
recently.
Landsat satellites have collected images of our planet and helped understand how land usage has changed over
the decades. The first Landsat was launched in 1972.
Landsat 9 joins Landsat 8 that was launched in 2013 and the satellites together will collect images of Earth’s
surface.
It takes 8 days to capture the whole Earth. It will make contact with a ground station every few hours and offload
its data.
As the satellite orbits, these instruments will take pictures across 185 kms and each pixel will represent an area
of about 30 meter X 30 meter.
These instruments will measure different wavelengths of light reflected off the Earth’s surface.
It can see more colour shades with greater depths.
Uses - Previously, Landsat images have been used to study the health of forests, coral reefs, monitor water
quality and melting glaciers.
Landsat 9 will provide data that can help make science-based decisions on key issues of climate change such as
impacts of wildfire, coral reef degradation, the retreat of glaciers, and deforestation.
It can help identify water bodies affected by potentially harmful algal blooms.
Despite the fact that they really are in a very small region of space, they're very physically different from one
another.
Trojans are a type of co-orbital object, where a star and a planet orbit around a common barycentre.
Sampling process - The rover carries 43 titanium sample tubes and is supposed to collect samples (rock and
regolith) from the Jezero Crater.
Perseverance’s sampling process is autonomous - its sampling and caching system uses a hollow coring bit and
percussive drill that is fixed at the end of its 7-feet-long robotic arm.
To know more about the Perseverance Rover, click here.
Parker was 13 million kms from the center of the sun when it first crossed the jagged, uneven boundary between
the solar atmosphere and outgoing solar wind.
Now, the spacecraft found itself in a region where the magnetic fields were strong enough to dominate the
movement of particles there.
These conditions were the definitive proof the spacecraft had passed the Alfvén critical surface and entered the
solar atmosphere where magnetic fields shape the movement of everything in the region.
The corona appeared dustier than expected. Because the sun lacks a solid surface, the corona is where the action
is.
Significance - Future coronal excursions will help us better understand the origin of the solar wind, and how
it is heated and accelerated out into space.
Exploring this magnetically intense region up close can help us better understand solar outbursts that can
interfere with life on Earth.
It will provide us with deeper insights into our Sun's evolution and its impacts on our solar system, and
everything we learn about our own star (the sun) also teaches us more about stars in the rest of the universe.
So, the Parker will keep drawing ever closer to the sun and diving deeper into the corona until its grand finale
orbit in 2025.
Significance - Eventually, the learnings from the Artemis programme will be utilised to send the first
astronauts to Mars.
NASA plans on using the lunar orbit to gain the necessary experience to extend human exploration of space
farther into the solar system.
Tianhe - In April 2021, China launched the core module of the space station - "Tianhe" or "Harmony of the
Heavens" - on the Long March 5B.
Tianhe will act as the management and control hub of the space station. It is a cylinder, which is China’s largest
spacecraft.
1.38 EnVision
EnVision is a European Space Agency (ESA) led mission.
Its orbiter will visit Venus in the 2030s.
Once launched on an Ariane 6 rocket, the spacecraft will reach
Venus in 15 months and will take 16 more months to achieve
orbit circularisation.
The spacecraft will study the planet’s atmosphere and surface,
monitor trace gases in the atmosphere and analyse its surface
composition.
Radar provided by NASA will help to image and map the
surface.
At the core of the ESA’s mission is the question of how Earth
and Venus evolved so differently from each other considering that they are roughly of the same size and
composition.
EnVision will follow another ESA-led mission ‘Venus Express’ (2005-2014) that focussed on atmospheric
research and pointed to volcanic hotspots on the planet’s surface.
1.39 Nauka
Russia’s space agency Roscosmos will be attaching a module called Nauka (“science” in Russian) to the International
Space Station (ISS).
Nauka is a significantly larger module that will replace a Russian module called Pirs (“pier” in Russian), which
was detached from Zvezda module of the ISS using a Progress MS-16/77P cargo ship.
[Pirs module was used as a docking port for spacecraft and as a door for cosmonauts to go out on spacewalks.]
Nauka was launched from the Baikonur Cosmodrome in Kazakhstan using a Proton rocket, Russia’s most
powerful space inventory.
It is the biggest space laboratory Russia has launched to date, and will serve as a Russia’s main research facility
on the ISS.
On the ISS, Nauka will be attached to the critical Zvezda module, which provides all of the ISS’s life support
systems.
[Zvezda module serves as the structural and functional centre of the Russian Orbital Segment (ROS), the
Russian part of the ISS.]
1.40 Beresheet 2
SpaceIL, the nonprofit Israeli initiative has secured $70 million fund to make a second attempt at a lunar
landing through Beresheet Project.
Beresheet 1 or “Genesis spacecraft” built by SpaceIL suffered technical malfunctions and crashed on the moon
in 2019.
Beresheet 2 was announced in 2020, aiming at landing an unmanned craft on the moon in 2024.
It plans to set new global space records through a double landing on the moon and the instalment of the lightest
ever moon landers, each weighing 60 kg without fuel.
The objective of this mission is to conduct experiments and collect data on behalf of school students.
It will be composed of three spacecraft - an orbiter named Mothership’ and two landers - that would circle the
moon for years.
Significance - The mission hopes to follow China in becoming only the second to successfully land on the far
side of the moon.
Israel would become the fourth nation to land a spacecraft on the moon, only after the former Soviet Union, the
US and China.
This resolution defines three “accelerators” to further advance Europe’s space ambitions.
First accelerator is for the ESA to work towards the ‘Space for a Green Future’, so that people are better able
to understand the current state of Earth and to develop scenarios and solutions for sustainable life here.
o This is in line with achieving net-zero greenhouse gas emission targets by the year 2050.
Second accelerator ‘Rapid and Resilient Crisis Response’ aims to support governments to act decisively
on crises facing Europe, from flooding and storms to wildfires.
Third accelerator is ‘Protection of Space Assets’, whose objective is to safeguard ESA astronauts and assets
from interference by space debris and space weather.
Other than this, the council recognised two “inspirators” to reinforce European management in science,
expertise growth and inspiration,
1. An icy moon pattern return mission and
2. Human space exploration.
1.47 ExoMars
There will be a delay in the ExoMars 2022 Mission that was to be launched in September 2022 as the European Space
Agency (ESA) suspended all its cooperation with Russian space agency Roscosmos.
Once a joint space venture between ESA and Roscosmos, ExoMars is now ESA’s mission to Mars.
It aims to look for whether life has ever existed in Mars.
The ExoMars programme comprises 2 missions.
1. The first mission was launched in 2016 and consists of the Trace Gas Orbiter (TGO) and Schiaparelli,
an entry, descent and landing demonstrator module.
2. The second mission is planned to be launched in 2022 and comprises a rover and surface science
platform.
The rover that will carry a drill and a suite of instruments dedicated to search for possible existence of life beyond
earth and geochemistry research.
It is likely to land on Mars’ equator called Oxia Planum, which had housed a massive pool of water in the
prehistoric era.
1.50 IN-SPACe
The Government of India has created the Indian National Space Promotion and Authorization Center (IN-SPACe), an
independent nodal agency under the Department of Space.
IN-SPACe will be an autonomous nodal agency under the Department of Space.
It is supposed to be a facilitator and a regulator. It will act as an interface between ISRO and private parties.
It will provide the necessary support for the private space industry to conduct its activities.
It will assess the needs and demands of private players including educational and research institutions.
It will explore ways to accommodate these requirements in consultation with ISRO.
Currently, there are more than 500 private companies which partner with the Indian Space Research
Organization (ISRO) in carrying out various space activities.
They provide materials used in manufacturing, mechanical fabrication, electronic fabrication, system
development, integration, etc.
Under the new system
1. The government will allow utilizing those infrastructures of ISRO which are otherwise not available
elsewhere in India.
2. Permit establishment of facilities, within ISRO premises, based on safety norms and feasibility assessment.
3. The decision of IN-SPACe shall be final and binding on all stakeholders including ISRO and private players
will not be required to seek separate permission from ISRO.
Existing ISRO infrastructure, scientific and technical resources and even data are planned to be made accessible
to interested parties. [The infrastructure includes both ground- and space-based.]
1.52 Inspiration4
SpaceX is going to launch ‘Inspiration4’, the world’s 1st all-civilian, non-governmental spaceflight soon.
This mission will take 4 private citizens into space in the Crew Dragon spacecraft, which will be privately
operated by SpaceX.
This mission involves circling the Earth for 3 days at the height of 575km (low Earth orbit), and then splashing
down into the Atlantic Ocean.
This will be the farthest distance travelled by a crewed mission since 2009, when astronauts went to repair the
Hubble telescope (547km).
The dome window has been inspired by the Cupola, a module on the International Space Station used to make
observations about our planet.
Significance - The journey will present an opportunity for collecting many health data that will aid in planning
future crewed space missions.
This will help in assessing behavioural and cognitive changes over the journey.
The travellers will undergo balance and prescription tests just before and after their journey to assess their
response to the change in gravity.
2. PLANETARY SYSTEMS
Introduction
According to IAU’s guidelines, the privilege of naming a planet is first given to discoverers, who have 10 years
to propose a name.
The discoverer or team is expected to write a short citation, explaining the reasons for assigning the name.
All names proposed are judged by the 15-member Working Group for Small Body Nomenclature (CSBN) of the
IAU.
It has recently named an asteroid after Indian classical singer Pandit Jasraj.
It is located between Mars and Jupiter, and was discovered on November 11, 2006 by the Arizona based
telescope.
2.6 Arrokoth
Ultima Thule, the farthest cosmic body ever visited by a spacecraft,
has been renamed Arrokoth, or “sky” in the Native American
language.
Arrokoth is icy rock, which orbits in the dark and frigid Kuiper Belt
about a billion miles beyond Pluto.
Arrokoth is an example of a “cold classical object” which has
remained undisturbed since the solar system formed some 4.5 billion
years ago.
It was surveyed by the NASA spaceship New Horizons in January
2019, with images showing it consisted of two spheres stuck together in the shape of a snowman.
The new official name, which was chosen by the New Horizons team and ratified by the International
Astronomical Union.
2.7 TRAPPIST-1
It is a system of seven Earth-size planets orbiting an ultra-cool dwarf star about 40 light-years away.
This is by far the largest collection of Earth-like planets in the habitable ‘Goldilocks’ zone of a star.
Goldilocks represents a zone which is neither too close nor too far from a star, which raises the possibility of
liquid water being present on the surface.
Unlike earlier discoveries of exoplanets, all seven planets could possibly have liquid water.Three of the planets
have the greatest chance.
Since the initial discovery of three planets was made using the Chile-based Transiting Planets and Planetesimals
Small Telescope, the exoplanet system is called TRAPPIST-1.
The TRAPPIST-1 planets have lower densities than Earth.
In a new study, researchers found that the TRAPPIST-1 star is quite old: between 5.4 and 9.8 billion years.
Recent evidence from NASA’s Hubble space telescope revealed that earth sized exoplanets in the Trappist-1
system may contain water.
Recent Developments
Detailed modelling of the recent afterglow indicates that the parameters describing the fraction of energy in
electron population and magnetic field are evolving with time and not constant as generally seen in GRBs.
The evolution of these parameters, at early times, may play a role in producing the bright TeV emission.
The peak activity of a meteor shower is on November 17. The peak time comes when the Earth passes through
the densest part of the debris.
The meteors originate from the comet 55P/Tempel-Tuttle, which orbits the sun every 33 years in the
constellation Leo.
Earth passes through this trail of meteors each year as it revolves around the sun, causing meteor showers (1,000
meteors per hour) to occur.
Leonids are the major shower that features the fastest meteors (speeds of 71 km/s), although the rates are often
as low as 15 meteors per hour.
They are also called fireballs (because of their bright colours) and earthgazer meteors (because they streak close
to the horizon.)
The light is a result of the friction between the meteorite and the molecules present in the Earth’s atmosphere
because of which it burns.
The last Leonid storm took place in 2002.
Visibility - The showers are visible on any cloudless night when the Moon is not very bright. They are best
viewed at about midnight.
Ideally, the viewing location should have no light pollution; the farther away from cities the better.
Meanwhile, dark energy is a repulsive force that causes the expansion of our universe.
2.20 Kamo’oalewa
A new study offers insights into where the Kamo’oalewa could have come from.
The asteroid Kamo’oalewa is a quasi-satellite of the Earth.
It is Earth's wobbly companion that was spotted in 2006 by the PanSTARRS telescope in Hawaii.
It is a near-Earth object (NEO) that orbits the Sun and gets as close as about 9 million miles from Earth.
It was named as Kamo’oalewa, a word that is part of a Hawaiian chant, and alludes to an offspring that travels
on its own.
Because of its small size (about 50 metres wide), this quasi-satellite has been difficult for scientists to study.
Possibilities - The study suggests that there is one possibility that
Kamo’oalewa was a part of the Earth’s Moon, that could have broken
away from the Moon due to a possible impact.
When scientists compared its spectrum with a lunar sample from the
Apollo 14 mission, there were striking similarities.
Second possibility is that Kamo’oalewa was captured in its Earth-like
orbit from the general population of Near Earth Objects.
Third possibility is that it originated from an undiscovered quasi-
stable population of Trojan asteroids of the Earth.
[Trojans are a group of asteroids that share an orbit with a larger planet.]
2.22 Magnetar
Researchers have succeeded in measuring for the first time the characteristics of a flare on a distant magnetar.
The flare, which spewed within a few tenths of a second as much energy as the Sun would shed in 100,000 years,
was captured in 2020 by the International Space Station’s Atmosphere-Space Interactions Monitor (ASIM)
instrument.
A magnetar is a rare compact type of neutron star teeming with energy and magnetism.
Only 30 Magnetars have been spotted within the Milky Way so far.
Formation - During the course of their evolution, massive stars (masses around 10-25 times the mass of the
Sun) eventually collapse and shrink to form very compact objects called neutron stars.
A subset of these neutron stars is the so-called magnetars.
Characteristics - Magnetars are isolated neutron stars with intense magnetic fields much higher than in
ordinary pulsars, typically ∼1015 G.
Magnetars emit energy in the range given by luminosities of 10 37 - 1040 joules per second. (Luminosity of our
sun = 1026 joules per second).
These are highly dense and have breathtakingly high rotation speeds (rotational periods can be just 0.3 to
12.0 seconds).
Further, these magnetars emit violent flares.
Eruptions in magnetars are believed to be due to instabilities in their magnetosphere, or “starquakes” produced
in their crust - a rigid, elastic layer about one kilometre thick.
This causes waves in the magnetosphere, and interaction between these waves causes dissipation of energy.
Magnetars are very difficult to observe when they are silent. It is only during a flare that they can be observed,
and these flares are so short-lived that it presents a formidable problem.
In cases where the stars are of equal brightness, the designation given by the discoverer is respected. Our Sun is
a solitary star.
Although binary stars are sometimes called double stars, the latter refers to any two stars that are close together
in the sky.
Thus, double stars include true binaries as well as stars that look close together when viewed from Earth but
which are actually quite far apart.
3.2 PASIPHAE
Polar-Areas Stellar-Imaging in Polarisation High-Accuracy Experiment (PASIPHAE) is an international
collaborative sky surveying project steered by the Institute of Astrophysics, Greece.
It will be used in upcoming sky surveys to capture polarisation (B-mode signal) coming from very faint stars
that are so far away that their polarisation signals haven’t been systematically studied.
The distances to these stars will be obtained from measurements of the GAIA satellite.
The survey will use two high-tech optical polarimeters to observe the northern and southern skies,
simultaneously.
By combining these data, astronomers will perform a maiden magnetic field tomography mapping of the
interstellar medium of very large areas of the sky using a novel polarimeter instrument known as WALOP.
As the survey will focus on sky areas where very low polarisation values (<0.5%) are expected to emerge, a
polarimeter with high sensitivity and accuracy was needed, so WALOP was planned sometime in 2013.
The maximum observation time offered by the smaller telescopes will be diverted for the PASIPHAE sky survey
using WALOP.
WALOP
Wide Area Linear Optical Polarimeter (WALOP) can detect polarised light signals coming from the stars along
high galactic latitudes.
Each WALOP will be mounted on two small optical telescopes,
a) The 1.3-metre Skinakas Observatory, Crete, and
b) The 1-m telescope of the South African Astronomical Observatory, Sutherland.
The images obtained from WALOP will simultaneously have the finest of details of a star along with its
panoramic background.
a) WALOP can capture images within ½° by ½° area of the sky during every exposure.
b) WALOP will offer the widest ever view of the sky in polarimetry.
WALOP will operate on the principle that at any given time, the data from a portion of the sky under observation
will be split into 4 channels.
Depending on the manner in which light passes through the four channels, the polarisation value from the star
is obtained.
o Each star will have four corresponding images which when stitched together will help calculate the
desired polarisation value of a star.
WALOP and its predecessor RoboPol survey share the single shot photometry principle.
But WALOP will be capable of observing hundreds of stars concurrently present both in the northern and the
southern skies as opposed to RoboPol, which has a much smaller field of view in the sky.
The development of the instrument is in an advanced stage currently and progressing at the instrumentation
facility in IUCAA.
o It also contains a “secondary circuit”, which tells the payload computer that it should cease operations
if the voltage falls below or exceeds allowable levels.
Both the payload computer and the PCU are part of Hubble’s Science Instrument Command and Data Handling
(SI C&DH) unit.
About - Named after astronomer Edwin Hubble, the observatory is the first major optical telescope to be placed
in space.
It is larger than a school bus in size, has a 7.9 feet mirror.
It captures stunning images of deep space playing a major role in helping astronomers understand the universe
by observing the most distant stars, galaxies and planets.
The primary mirror, the lightweight mirrors, coatings, actuators and mechanisms, electronics, and thermal
blankets when fully deployed form a single precise mirror.
The primary mirror is made of 18 hexagonal-shaped mirror
segments stitched together in a honeycomb pattern.
The hexagonal shape allows for a roughly circular,
segmented mirror with high filling factor and six-fold
symmetry.
All these mirrors can fold up and fit into a rocket and then
unfold in space.
Each mirror segment is made from beryllium. Beryllium is
used as it is both strong and light.
After the beryllium mirror segments were polished a thin
coating of gold was applied to itusing a technique called
vacuum vapour deposition. Gold helps improve the mirror’s reflection of infrared light.
3.5 Neutrino
Tamil Nadu has said to the Supreme Court that it does not want the Indian Neutrino Observatory (INO) to be set up
in a sensitive ecological zone in the Western Ghats at a great cost to wildlife and biodiversity.
Neutrinos are the 2nd most abundant particles, after photons.
They come in three ‘flavours’ or ‘types’, and each flavour is associated with a light elementary particle. They are,
1. Electron-neutrino is associated with the electron;
2. Muon-neutrino with the muon and
3. Tau-neutrino with the tau particle.
They are not easy to catch, as they do not carry a charge, as a result of which they do not interact with matter.
They also might have unique properties that would help explain why the universe is made of matter instead of
antimatter.
Subatomic particles that make up antimatter have properties that are opposite to the subatomic particles of
normal matter.
Protons, neutrons and electrons (subatomic particles of normal matter) are among the 12 quarks and leptons
have been discovered so far.
To know about the Indian-based Neutrino Observatory, click here.
Related Links - Baikal-GVD, Neutrinos and Star Death
For years, we had thought that for some reason, nature had chosen to produce particles made only from two or
three quarks.
Only recently have physicists begun to see signs of exotic "tetraquarks" -- particles made from a rare
combination of four quarks.
X-particles
X particles that were produced in the quark-gluon plasma in the CERN’s Large Hadron Collider (LHC),
Switzerland are of a type known as X (3872), named for the particle's estimated mass.
As the background was overwhelming after the quark-gluon plasma forms and cools down, a machine-
learning algorithm was used to pick out decay patterns characteristic of X particles.
X (3872) is either a compact tetraquark or an entirely new kind of molecule made from not atoms but two
loosely bound mesons.
[Mesons are the subatomic particles that are made from two quarks.]
Discovery - X (3872) was first discovered in 2003 by the Belle experiment, a particle collider in Japan that
smashes together high-energy electrons and positrons.
Within this environment, however, the rare particles decayed too quickly for scientists to examine their
structure in detail.
It has been hypothesized that X (3872) and other exotic particles might be better illuminated in quark-gluon
plasma.
Significance - In the next few years they want to use the quark-gluon plasma to probe the X particle's internal
structure, which could change our view of what kind of material the universe should produce.
4. DEFENSE
Artillery
Vacuum bombs are not prohibited by any international law or agreement, but their use against civilian
populations in built-up areas, schools or hospitals, could attract action under the Hague Conventions of 1899
and 1907.
Missiles
4.5 Agni P
Defence Research and Development Organisation (DRDO) successfully flight tested a New Generation Nuclear
Capable Ballistic Missile Agni P from Dr APJ Abdul Kalam island off the coast of Odisha, Balasore.
Agni P is the first of the new generation advanced variant of Agni class of missiles. It has a range capability
between 1,000-2,000 kms
It weighs 50% less than Agni 3 and has new guidance and a new generation of propulsion.
Since it is a canisterised missile, it can be launched from rail and road and stored for a longer period and
transported all across the country as per operational requirements.
Due to its long range, this missile can be used to target enemy armadas in the Indo-Pacific.
South Korea and Israel face different security threats that require different responses.
1. Israel contends with Hamas, which is primarily a militant group, and irregular forces sporadically,
2. South Korea had to contend with North Korea, a nation with its own extensive military capabilities.
4.10 Agni-5
Agni-5 Missile was launched from the APJ Abdul Kalam Island, Odisha successfully.
Agni-5 Missile is a nuclear-capable long-range Surface to Surface Intercontinental Ballistic Missile (ICBM).
Agni-5 was developed by the Defence Research and Development Organisation (DRDO) as a part of the
Integrated Guided Missile Development Program (IGMDP).
It uses a 3-stage solid fuelled engine.
It is capable of striking targets at ranges up to 5,000
kms with very high degree of accuracy.
India began testing the Agni series of missile in 1989
with the 1st test for Agni 1, an Intermediate Range
Ballistic Missile, with the 1000-km range.
Significance - This Missile is capable of reaching
most parts of China.
Successful test of Agni-5 is in line with India’s policy to
have ‘credible minimum deterrence’ that underpins
the commitment to ‘No First Use’ of its nuclear
doctrine.
Thus, second strike capability - the capability to strike back after being hit by nuclear weapons first becomes
important.
Nuclear Triad
It refers to the delivery of nuclear weapons via land, sea and air
i.e.
1. Land-based intercontinental ballistic missiles (ICBMs),
2. Submarine-launched ballistic missiles (SLBMs), and
3. Strategic bombers.
The purpose of having this 3-branched nuclear capability is to
reduce the possibility that an enemy could destroy all of a
nation's nuclear forces in a first-strike attack.
This, in turn, ensures a credible threat of a second strike, and
thus increases a nation's nuclear deterrence.
Other methods of delivery could include orbital weapons, nuclear torpedo and hypersonic glide vehicles.
It can be activated within five minutes and has the flexibility to be integrated into the existing and future air
defence units of the air force, army and navy.
The S-400 also comes with improved electronic counter-countermeasures to tackle the attempts at jamming.
Another capability of S-400 is its “fire-and-forget capability" which does not require further guidance after
the launch and can hit the target without the launcher being in line-of-sight of the target.
Uses - S-400 can simultaneously track and neutralize many incoming objects spanning aircraft, missiles and
Unmanned Aerial Vehicles (UAV) over very long ranges.
It can provide air interception against early warning aircraft, airborne missile strategic carriers, tactical and
theatre ballistic missiles, medium-range ballistic missiles in a dense radio countermeasure scenario.
4.14 Pralay
Defence Research & Development Organisation (DRDO) successfully conducted maiden flight test of indigenously
developed surface-to-surface missile ‘Pralay’, from Dr A P J Abdul Kalam Island off the coast of Odisha.
'Pralay' is India's first conventional ballistic missile and is an answer to any conventional missile attack from
northern or western borders.
Pralay is a solid-fuel, surface-to-surface battlefield missile developed by DRDO based on Prithvi Defence Vehicle
from the Indian ballistic missile programme.
‘Pralay’ is a 350-500 km short-range missile with a payload capacity of 500-1,000 kg. It can be launched from
a mobile launcher.
The missile guidance system includes state-of-the-art navigation system and integrated avionics.
Detection - Hypersonic weapons could challenge detection and defence due to their speed, manoeuvrability
and low altitude of flight.
The ground based radars or terrestrial radars cannot detect hypersonic missiles until late in the flight of
the weapon.
This delayed detection makes it difficult for the responders to the missile attack to assess their options and to
attempt to intercept the missile.
Countries - While the US, Russia and China are in advanced stages of hypersonic missile programmes, India,
France, Germany, Japan and Australia too are developing hypersonic weapons.
Kinzhal Hypersonic Missile
The Kh-47M2 Kinzhal is Russia’s first operational conventionally armed hypersonic weapon. It is designed to
be carried by MiG fighter jets.
Kinzhal (or Dagger) is a hypersonic aeroballistic air-to-surface missile. It is said to be a modification of its
Iskander missile.
Russia claims that Kinzhal has a range of more than 2,000 km, and a speed of Mach 10.
4.20 MANPADS
The United States and NATO allies are shipping weapons into Ukraine at break-neck speed, including highly sensitive
items such as Man-Portable Air-Defense Systems (MANPADS).
Man-Portable Air-Defence Systems (MANPADS) are short-range,
lightweight and portable surface-to-air missiles used to destroy
aircraft or helicopters.
[Man-Portable Anti-Tank Systems (MANPATs) work in a similar
manner but are used to destroy or incapacitate military tanks.]
MANPADS are often described as shoulder-fired anti-aircraft
missiles.
They can be shoulder-fired by individuals or small groups, or can be
launched from atop a ground-vehicle, or fired from a tripod or
stand, and from a helicopter or boat.
They help shield troops from aerial attacks and are most effective in targeting low-flying aircrafts.
Features - Weighing between 10 to 20 kg and not being longer than 1.8 m, MANPADS have a maximum range
of 8 kilometres and can engage targets at altitudes of 4.5 km.
Most MANPADS have passive or ‘fire and forget’ guidance systems, meaning the operator is not required to
guide the missile to its target, enabling them to run and relocate immediately after firing.
The missile stays locked-on to the targeted object, not requiring active guidance from the soldier.
The missiles are fitted with Infrared (IR) seekers that identify and target the airborne vehicle through heat
radiation being emitted by the latter.
Concerns - Over time, non-state actors such as rebel and terrorist groups are known to have illicitly acquired
MANPADS, using them during civil wars and other high-intensity conflicts.
Russia is by far the biggest exporter of MANPADs, having sold over 10,000 such systems between 2010 and
2018 to various countries including Iraq, Qatar, Kazakhstan, Venezuela, and Libya.
Aircrafts
It records 88 vital parameters about a flight including, airspeed, altitude, cockpit conversations, and air pressure
among others.
There are two recorders in black box:
o Flight Data Recorder (FDR) that stores all the recent history of the flight through the recording of
dozens of parameters collected multiple times per second and.
o Cockpit Voice Recorder (CVR) that records cockpit sound including pilot conversations
To withstand the harshest crashes, the black box is double wrapped in a corrosion-resistant stainless-steel
container with high-temperature insulation.
If underwater, the device sends out a signal on contact with saltwater that can be picked up within a radius of
about 2 kilometres.
The P-8I is an integral part of the Indian Navy’s fleet and has surpassed 35,000 flight hours since it was inducted
in 2013.
Drones
4.26 HANSA-NG
HANSA-NG has successfully completed the sea level trials at Puducherry.
HANSA-New Generation (HANSA-NG) is India’s first indigenous Flying Trainer.
[HANSA-NG is the revamped version of the original HANSA developed three decades ago (1993).]
It is designed and developed by CSIR-National Aerospace Laboratories, Bangalore under the aegis of Council of
Scientific & Industrial Research.
HANSA-NG is one of the most advanced flying trainer powered by Rotax Digital Control Engine with unique
features like
1. Just-In-Time Prepreg (JIPREG) Composite light weight Airframe,
2. Glass Cockpit,
3. Bubble Canopy with wide panoramic view,
4. Electrically operated flaps etc.
CSIR-NAL further said that HANSA-NG is designed to meet the Indian flying club needs and it is an ideal
aircraft for Commercial Pilot Licensing (CPL) due to its low cost and low fuel consumption.
Submarines
Subsequently, India would make 12 of its own by 2030, taking the fleet size to 24, with the older submarines
getting decommissioned.
But the contract for P-75 was signed only by 2005, with France’s DCNS, now the Naval Group.
INS Kalvari, built in India in partnership with France’s Naval Group.
IAC-1 Vikrant was designed by the Navy’s Directorate of Naval Design (DND) and built by India’s state-run
Cochin Shipyard Limited (CSL).
Vikrant has a top speed of around 28
knots and a cruising speed of 18 knots
with an endurance of about 7,500
nautical miles.
It will operate MiG-29K fighter jets,
Kamov-31 helicopters, MH-60R
multi-role helicopters.
The construction of Vikrant propelled
India into a select group of countries
having capabilities to build state-of-
the-art aircraft carriers.
It is an example of ‘Atma Nirbhar
Bharat’ with more than 76%
indigenous content.
The ship has,
1. A very high degree of automation for machinery operation, ship navigation and survivability,
2. Propulsion and Power Generation equipment/ systems,
3. An incomparable military instrument with its ability to project Air Power over long distances.
It is designed with blue-water capability with ranges of up to 10,000 nautical miles for voyages lasting up to 45
days.
Sagar Nidhi plays an important role in exploring the ocean resources and participation in search and
rescue operations, especially its importance for implementation of Deep Ocean Mission.
Research Vessel
Research Vessel (Ships) is an important tool for ocean research, development of ocean technology and Ocean
Survey of the Exclusive Economic Zone (EEZ) and deep oceans for minerals and energy.
Ministry of Earth Sciences (MoES) has the mandate of providing weather, climate, Ocean and seismological
services and to harness living and non-living resources.
So, MoES has 6 ships - Sagar Nidhi, Sagar Manjusha, Sagar Kanya, Sagar Sampada, Sagar Tara & Sagar
Anveshika.
The ships under Project 28 have been designed locally by the Navy’s in-house Directorate of Naval Design
(DND).
These were built locally by Kolkata based Garden Reach Shipbuilders and Engineers.
5. HEALTH
COVID-19
It is known for its significant reduction in neutralization by antibodies generated during previous infection or
vaccination, reduced effectiveness of treatments or vaccines, or diagnostic detection failures.
Example - Alpha, Beta and Delta variants of SARS-CoV-2.
Variant of High Consequence – It has clear evidence that prevention measures or medical countermeasures
(MCMs) have significantly reduced effectiveness relative to previously circulating variants.
It is an acknowledgement of the fact that the variant has caused significant community transmission in multiple
countries and population groups.
Other Designations - There are currently seven variants that the WHO classifies as “Variants of Interest”.
Another four - Alpha, Beta, Gamma and Delta - have been designated as “Variants of Concern”, and are
considered a bigger threat. These variants were all named after letters of the Greek alphabet.
5.5 Mu Variant
WHO has classified yet another SARS-CoV-2 variant “B.1.621” as a variant of interest (VOI) and given it the label
“Mu”.
The variant was first identified in Colombia in January, 2021.
Spread - The global prevalence of the Mu variant among sequenced cases has declined and is currently below
0.1%.
However, prevalence in Colombia (39%) and Ecuador (13%) has consistently increased.
Larger outbreaks were reported from countries in South America and Europe.
Cases have also been reported in the UK, US and Hong Kong.
It was added to Public Health England’s list of variants under investigation.
Some monoclonal antibodies have shown the ability to retain activity against multiple variants of the virus.
Limitations - Monoclonal antibodies are not approved for use in those hospitalised with severe Covid-19 and
those requiring oxygen.
Some emerging variants like the Delta Plus “variant of interest” have also displayed the ability to nullify the use
of monoclonal antibodies.
5.9 Corbevax
India has placed an advance order to block 300 million doses of Covid-19 vaccine, Corbevax, from Hyderabad-based
company Biological E.
Working of Corbevax - Corbevax is a “recombinant protein sub-unit” vaccine, which means it is made up of
a specific part of SARS-CoV-2 — the spike protein on the virus’s surface.
The spike protein allows the virus to enter the cells in the body so that it can replicate and cause disease.
However, when this protein alone is given to the body, it is not expected to be harmful as the rest of the virus is
absent.
The body is expected to develop an immune response against the injected spike protein.
So, when the real virus attempts to infect the body, it will have an immune response ready that will make it
unlikely for the person to fall severely ill.
Making of Corbevax - Corbevax’s beginnings can be traced to the Baylor College of Medicine’s (BCM’s)
National School of Tropical Medicine.
They put the gene sequence for the spike protein into yeast, so that it could manufacture and release copies of
the protein.
After this, the protein was purified to remove any remnants of the yeast. Then, the vaccine was formulated using
an adjuvant to better stimulate the immune response.
Later, BCM transferred its production cell bank for this vaccine to Biological E, so that Biological E could take
the candidate through trials.
Difference - Other Covid-19 vaccines approved so far are either,
1. mRNA vaccines (Pfizer and Moderna),
2. Viral vector vaccines (AstraZeneca-Oxford/Covishield, Johnson & Johnson and Sputnik V) or
3. Inactivated vaccines (Covaxin, Sinovac-CoronaVac and Sinopharm’s SARS-CoV-2 Vaccine–Vero Cell).
Corbevax, like the mRNA and viral vector Covid-19 vaccines, targets only the spike protein, but in a different
way.
Viral vector and mRNA and vaccines use a code to induce our cells to make the spike proteins against which the
body have to build immunity.
In this case (Corbevax), we’re actually giving the protein.
Inactivated vaccines, which include killed particles of the whole SARS-CoV-2 virus, attempt to target the entire
structure of the virus. Like most other Covid-19 vaccines, Corbevax is administered in two doses.
5.10 Soberana
Cuba’s State-run corporation BioFarma’s Soberana 2 and Abdala vaccines have shown greater-than-90%
efficacy.
Both the vaccines are three-shot vaccines. Both are subunit vaccines, meaning that a part of the virus forms the
antigen and is hitched on to another construct.
o In Abdala, the spike protein of the coronavirus is combined with a chemically manufactured adjuvant,
o In Soberana 2, the spike protein is chemically linked to the tetanus toxoid, making it a conjugate vaccine.
The Soberana vaccine is by far the only one among coronavirus vaccine candidates that relies on the conjugate
vaccine technology.
Conjugate Vaccines
A conjugate vaccine is a type of vaccine which combines a weak antigen with a strong antigen as a carrier so that
the immune system has a stronger response to the weak antigen.
The most common conjugate vaccines are those used for Haemophilus influenza type b and the pneumococcal
bacteria.
Cuban vaccine candidates are based only on the part of the virus that is involved in contact with the cell’s
receptor, the Receptor-Binding Domain (RBD).
The RBD is the one that induces the greatest number of neutralising antibodies.
Cheimi-Hib - It is another vaccine already developed by Cuba with this principle. It is the world’s second
Conjugate Vaccine, against haemophilus influenzae type b.
[Haemophilus influenzae type b is a coccobacilli responsible for diseases such as meningitis, pneumonia and
epiglottitis.]
5.15 R Value
The R value, which reflects how rapidly the COVID-19 pandemic is spreading, dropped to 0.92 by mid-September after
going over one in August-end.
R-value or R-factor or R0 (R-naught) or Reproduction Rate refers to how
many persons an infected person infects on an average.
It indicates the speed at which the Covid infection is spreading in the
country, along with the ‘efficiency’ of the spread.
Interpretation - An R-Factor of 1 would mean that an infected person is
giving the virus to 1 other person. An R-Factor of 5 would mean that 1
person is spreading the virus to 5 other people.
A NITI Aayog member says that R number should be 0.6 or below. If it is
above 1, it shows that it is a significant problem and the virus wants to
spread.
Cuban government said that the nationwide inoculation drive for children was being sped up with the reopening
of schools for in-person classes in mind from October, 2021.
Initially the focus of Cuba’s vaccination drive was inoculating frontline
workers and elderly people in badly affected areas.
But after a spike in infections among children following the emergence
of the Delta variant, Cuba shifted its focus to vaccinating younger
children.
Vaccinating children & other low-risk groups is being criticised because
billions around the world have not received even one shot, which even
includes some frontline workers.
Cuban Vaccines
In Cuba, Children and adolescents will receive doses of Soberana-2, while adults will receive Abdala.
Both Soberana 2 and Abdala are conventional conjugate vaccines, which mean that a part of the coronavirus
spike protein is fused with a carrier molecule in order to boost both efficacy and stability.
But, both of these vaccines are not recognised by the WHO.
5.19 i-Drone
Union Health Minister launched ICMR’s Drone Response and Outreach in North East (i-Drone), which is a drone-
based vaccine delivery model.
This delivery model will ensure that life-saving vaccines reach everyone, including the remote areas and hard to
reach terrains.
This is for the first time that a ‘Make in India’ drone has been used in South Asia to transport COVID vaccine.
It was used to deliver vaccines in Manipur, Nagaland and Andaman and Nicobar.
It will epitomise the Government’s commitment to ‘Antyodaya’ in health; make healthcare accessible to the last
citizen of the country.
The booster is designed to help people maintain their level of immunity for longer.
A booster shot gives the memory cells the crucial signal to re-engage when the virus attacks. So, it helps people
maintain their level of immunity for longer durations.
Dosage - While the additional Covid dose would be a “full” dose of the vaccine, booster shots being offered right
now have a lesser volume, since the third dose is only supposed to increase the efficacy range.
5.21 Pseudoephedrine
Pseudoephedrine is largely known as a sympathomimetic drug.
It is in a class of medications called nasal decongestants that is used to relieve nasal congestion caused by
allergies, cold and hay fever.
It also temporarily relieves sinus congestion and
pressure.
Pseudoephedrine will relieve symptoms but will not
treat the cause of the symptoms or speed recovery.
It works by causing narrowing of the blood vessels in
the nasal passages.
Other uses - Legally, this substance is used in the
manufacturing of amphetamines, which can be sold
only on the prescription of doctors.
Illegally, it is used in the making of drugs, which are
sold without any prescription.
Status in India
Pseudoephedrine is a controlled substance, as it is being used for making the highly addictive drugs.
It is one of the 7 controlled substance in India, which is being used by pharmaceutical companies in making
various medicines.
Other controlled substances are Acetic Anhydride, Ephedrine & its Salts, N-Acetyl Anthranilic Acid, Anthranilic
Acid and two others.
These substances are also known as precursor substances. They are used for manufacturing narcotics drugs and
psychotropic substance.
Section 9A of the Narcotics Drug and Psychotropic Substances (NDPS) Act, 1985 authorizes the law enforcement
agencies to control and regulate these substances, including pseudoephedrine in India.
Working of vaccines - Generally, both the aforementioned types of vaccines trigger a response in the blood.
B cells would churn out antibodies - including IgG (particularly potent disease-fighter) - to roam the body in
search of the virus.
Other cells, called T cells, would either help B cells produce antibodies or seek out and destroy the infected cells.
Working of Intranasal vaccine - However, vaccines that are injected through the nose or mouth would also
tap into another set of immune cells that hang around mucosal tissues.
The B cells that reside there can make another type of antibody called IgA that plays a large role in destroying
the airway pathogens.
In addition to this, the T cells that are residing nearby will be able to memorise the pathogens that it encountered
and will lifelong scout the areas where these were first encountered.
Importance - Intranasal vaccines are easy-to-deliver vaccines.
As they go into a mucosal surface, it will likely be restricted (and there is a) likelihood of lower safety events.
Intranasal vaccines aim to overcome potential difficulties with mass vaccination and reduce the cost by doing
away with the need for needles and syringes.
These vaccines are also expected to cut down on the dependence on various trained personnel to administer the
vaccine.
Drawbacks - Vaccines that arouse mucosal immunity come with their own drawbacks.
After the rollout of the oral polio vaccines where in some cases, it still caused the disease after the weakened
virus in the product mutated.
Also, there is very little evidence to back the effectiveness of this route of delivery so far.
Zoonotic Spillover
Coronaviruses are a large family of viruses that are known to infect animals and humans.
They are largely categorised into four genera - alpha, beta, gamma and delta.
Alpha and beta coronaviruses commonly infect mammals such as bats and humans, while Gamma and Delta
mainly infect birds.
A number of human coronaviruses have been identified previously, including OC43, HKU1, 229E, NL63, SARS-
CoV and MERS-CoV.
While animals are generally considered as the reservoirs of corona viruses, rarely spillover events could occur.
It is possible for viruses that infect animals to jump to humans, a process which is known as zoonotic spillover.
Identified in 2012, the MERS-CoV was transferred to humans through infected dromedary camels through
zoonosis.
SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, belongs to the genus of beta coronavirus.
In fact, it is the 7th type of coronavirus known to infect and cause severe disease in humans. It is thought to be
a result of spillover.
Significance - The interactions between humans and animals continue to increase, given the expanding
human population and encroachment of animal habitats.
While the likelihood of spillover events is rare, an increased interaction can potentially accelerate such events.
To prevent future outbreaks, it will thus be important to monitor this family of viruses for potential zoonosis.
Genomic surveillance of human and animal viruses is therefore the key to understanding the spectrum of
viruses, and possibly provide early warning to potential spillover events.
Diseases in News
VIRAL DISEASES
5.27 Filoviruses
In 2019, the Union Health Ministry began an inquiry into an Indian study that looked at filoviruses.
It said that this study conducted by the National Centre for Biological Sciences (NCBS) and Tata Institute of
Fundamental Research (TIFR) didn’t get the appropriate permissions from the ICMR.
Filovirus is any virus belonging to the family Filoviridae. They have enveloped virions appearing as variably
elongated filaments.
Virions are pleomorphic (varying in shape) and contain a helical nucleocapsid, which has a protein shell and
contains the viral nucleic acids.
The filovirus genome is made up of a single strand of negative-sense Ribonucleic Acid (RNA), and an
endogenous RNA polymerase.
Filoviridae consists of two genera, Marburgvirus and Ebolavirus.
1. The first strain of Marburgvirus was discovered in 1967, when it was transported with imported
monkeys to Marburg, Germany, and caused a fatal outbreak.
2. The first strain of Ebolavirus was discovered in 1976, taking its name from the Ebola River in the
northern Congo basin of Central Africa, where it first appeared.
Filoviruses are confined primarily to regions of central, eastern, and western Africa.
They are among the most dangerous human pathogens known, causing highly fatal hemorrhagic fevers; some
strains of Ebolavirus cause death in 50 to 90% of victims. The filoviruses may cause disease in primates.
Marburg and Ebola strains have been found in different species of fruit bats.
Treatment - There is no treatment available for Zika virus infection or its associated diseases.
Prevention - As the Aedes mosquitoes breed in stagnant fresh water, these breeding grounds should be
prevented from being created.
The Gambusia fish may be released in stagnant water bodies.
5.31 National Action Plan for dog Mediated Rabies Elimination by 2030
National Action Plan for dog Mediated Rabies Elimination by 2030 (NAPRE) was launched recently.
It wants to eliminate Dog mediated Rabies (Hadakwa disease) from India by 2030 through One Health
Approach including community education, awareness programmes and
vaccination campaigns.
Rabies is a zoonotic, viral disease spread to people from the saliva of infected
animals.
It is a Neglected Tropical Diseases (NTD) that mostly affects poor and
vulnerable populations. 80% of cases occur in rural areas.
Spread - Dogs are the main source of human rabies deaths, contributing up
to 99% of all rabies transmissions to humans. It is also transmitted through
bats, coyotes, foxes, raccoons and skunks.
In rare cases, rabies can be spread when infected saliva gets into an open wound or the mucous membranes,
such as the mouth or eyes.
Symptoms - Incubation period for rabies is 2 to 3 months. But this may vary from 1 week to 1 year, depending
upon factors like the location of virus entry and viral load.
Initial symptoms - Fever with pain and unusual or unexplained tingling, pricking, or burning sensation
(paraesthesia) at the wound site.
As the virus spreads to the central nervous system, progressive and fatal inflammation of the brain and spinal
cord develops.
Prevention - Interrupting transmission is feasible through vaccination of dogs and humans, and prevention
of dog bites.
Diagnosis - Current diagnostic tools are not suitable for detecting rabies infection before the onset of clinical
disease. It is diagnosed after rabies-specific signs of hydrophobia or aerophobia are seen.
Treatment of a bite victim after rabies exposure is the Post-exposure prophylaxis (PEP), which prevents virus
entry into the central nervous system. PEP consists of:
1. Extensive washing and local treatment of the bite wound or scratch as soon as possible after a suspected
exposure;
2. A course of potent and effective rabies vaccine; and
3. Administration of rabies immunoglobulin (RIG), if indicated.
WHO leads the ‘United Against Rabies’ to drive progress towards “Zero human deaths from dog-mediated rabies
by 2030”.
5.32 Dengue
Delhi has reported the highest number of dengue cases since 2018.
Dengue is a mosquito-borne tropical disease caused by the dengue virus (Flavivirus) transmitted by several
species of mosquitoes within the genus Aedes.
Symptoms typically begin three to fourteen days after infection.
These may include high fever, headache, muscle, and joint pain, and
a characteristic skin rash that is similar to measles.
There are four types of dengue strains, and type II and IV are
considered to be more severe and normally require hospitalisation.
In a small proportion of cases, the disease develops into,
a. Dengue hemorrhagic fever - A severe dengue resulting in
bleeding, low levels of blood platelets and blood plasma
leakage, or
b. Dengue shock syndrome - Dengue resulting in very low BP.
A WHO study said that this strategy of using indigenous or exotic fish species with larvivorous potential (fish
that feed on larvae) is potentially safer as it doesn’t involve use of insecticides.
It also states that this strategy is scientifically proven to be effective in malaria control.
Biocontrol
Biocontrol is the management of a pest or an insect, typically invasive species, using biological agents.
It is defined as the reduction of pest populations by introducing a natural predator into the environment.
Also known as Biological Control or natural control, it is a component of an integrated pest management
strategy.
Examples of biological control agents are predators, parasitoids, pathogens, insects, nematodes, etc.,
5.35 Norovirus
PyeongChang 2018, the ongoing XXIII Olympic Winter Games at Pyeongchang, South Korea has been hit by a disease
outbreak - Norovirus infection.
Norovirus is a bug similar to the diarrhoea-inducing rotavirus for which India has included a vaccine in its
universal immunisation programme.
While rotavirus primarily affects children, Norovirus infects people across age groups.
Disease outbreaks typically occur aboard cruise ships, in nursing homes, dormitories, and other closed spaces.
Symptoms usually show up 1 or 2 days after exposure to the virus. This includes a sudden onset of vomiting
and/or diarrhoea, nausea and abdominal pain, and may have fever, headaches and body aches.
In extreme cases, loss of fluids could lead to dehydration.
This self-limiting disease normally lasts only 2 or 3 days, and most individuals who are not very young, very
old, or malnourished can ride it out with sufficient rest and hydration.
Transmission - Norovirus is highly contagious, and can be transmitted through contaminated food, water,
and surfaces. The primary route is oral-faecal.
One may get infected multiple times as the virus has different strains.
Norovirus is resistant to many disinfectants and heat up to 60°C.
Therefore, merely steaming food or chlorinating water does not kill the virus. The virus can also survive many
common hand sanitisers.
Commonality - Norovirus is the most common pathogen implicated in outbreaks of gastrointestinal disease
(inflammation of the stomach and intestines), according to the World Health Organisation.
The US Centers for Disease Control and Prevention estimates that 1 out of every 5 cases of acute gastroenteritis
globally is caused by Norovirus.
Prevention - The basic precaution is repeatedly washing hands with soap after using the lavatory or changing
diapers; and before eating or preparing food.
During outbreaks, surfaces must be disinfected with hypochlorite solution at 5,000 parts per million.
Treatment - Diagnosis is done by real-time reverse transcription polymerase chain reaction.
No vaccines are available for the disease. It is important to maintain hydration in the acute phase.
In extreme cases, patients have to be administered rehydration fluids intravenously.
5.37 Parvovirus
Nearly 2,000 dogs in Amravati city were affected by canine parvovirus virus with veterinarians cautioning pet
owners against a severe outbreak.
Canine Parvovirus (CPV) is a highly contagious viral disease that has reported a 90% mortality rate in puppies
and dogs.
It affects the intestinal tract of canines with puppies being more susceptible.
Symptoms - Bloody diarrhoea, vomiting, drastic weight loss, dehydration and lethargy.
Spread - The highly contagious virus spreads through direct contact with an infected dog or by indirect contact
with a contaminated object, including the hands and clothing of people who handle infected dogs.
The dogs can get exposed to the parvovirus every time it sniffs, licks, or consume infected faeces.
Prevention - Parvovirus has no cure and inoculating a puppy or a dog gives them a fighting chance against the
infection.
The first dose is given at 45 days old and the second dose after 21 days.
To properly protect canines, it is necessary to administer the vaccine to them while they are puppies and then
continue to do the same every year.
Treatment - Currently, there is no specific drug available to kill the Canine Parvovirus.
Supportive care for parvovirus generally includes hospitalization with intravenous fluids, Antiemetics to stop
vomiting, Correction of any electrolyte imbalances or low blood glucose.
BACTERIAL DISEASES
5.41 Fusobacterium
Several groups have corroborated the finding that oral tumours among Indian patients are not driven by HPV
infection but by theFusobacterium.
Fusobacterium species is a genus of anaerobic, elongated, Gram-negative, non-sporeforming bacteria, similar
to Bacteroides.
They are common obligately anaerobic bacteria of the oral cavity that may act as a bridge between early and late
colonizing bacteria in dental plaque and have a role in oral and extra-oral infections.
There are multiple species of Fusobacterium, but the one most associated with human disease is F.
Necrophorum.
F. Necrophorum is a cause of periodontal disease, tonsillitis, peritonsillar abscess, and thrombophlebitis of the
jugular vein (Lemierre syndrome).
Since the beginning of the 20th Century, Fusobacteriumis known that infections could play a role in cancer, with
18-20% of cancers associated with infectious agents.
This could be relatively higher in developing countries like India, than in the developed countries where the
incidence of human papillomavirus (HPV) genome is more.
Fusobacterium nucleatum has a crucial role in oral biofilm structure and ecology, as revealed in experimental
and clinical biofilm models.
5.42 Mosquirix
Mosquirix or RTS,S/ASO1 (RTS.S), which was endorsed by the World Health Organisation (WHO) is the first and only
vaccine shown to have the capability of significantly reducing malaria.
This is the first malaria vaccine that has completed the clinical development process and acts against
Plasmodium falciparum.
Mosquirix provides short-term protection that could potentially save lives in the age group most at risk from
malaria.
Mosquirix also helps protect against infection of the liver with the hepatitis B virus but should not be used only
for this purpose.
The active substance in Mosquirix is made up of proteins found on the surface of the P. falciparum parasites
and the Hepatitis B Virus.
The vaccine thus limits the ability of the parasites to mature in the liver.
Malaria is a life-threatening disease caused by parasites transmitted to people through the bites of infected
female Anopheles mosquitoes and disease is preventable and curable.
WHO has recommended that the RTS,S/AS01 malaria vaccine be used for the prevention of P. falciparum.
NON-COMMUNICABLE DISEASES
5.46 Aducanumab
Aducanumab (Aduhelm), from the company Biogen, is the new drug approved by the US Food and Drug
Administration (FDA) for treating Alzheimer’s disease.
Aduhelm is not a cure, but it slows down cognitive decline.
Alzheimer’s disease causes the accumulation of the debris caused by the breakdown of neurons in the brain,
leading to plaque formation.
So, Aducanumab is a monoclonal antibody that is designed to reduce the presence of amyloid beta, a protein
that forms plaques in the brain.
Alzheimer’s Disease
Dementia is an umbrella term for a range of conditions that involve a loss of cognitive functioning.
Alzheimer’s dementia is the most common type and involves plaques and tangles forming in the brain.
Symptoms - Forgetfulness and memory problems are early symptoms.
But as the illness progresses, patients tend to become confused, may lose their way around familiar places, and
have difficulties with planning and completing simple tasks.
The disease is basically an accelerated ageing of certain neurons in the brain that are concerned with storage
and processing of memory.
Estimates - According to World Health Organization (WHO) estimates for 2017, dementia affects
approximately 50 million people worldwide.
This is projected to grow to 82 million by 2030.
In India, it is estimated that 5.3 million people (1 in 27) above the age of 60 have dementia in 2020, as per the
Dementia in India 2020 report (published by the Alzheimer’s and Related Disorders Society of India).
This is projected to rise to 7.6 million by 2030.
While the World Health Organization doesn’t recognise Peter Pan Syndrome as a health disorder, many experts
believe it is a mental health condition that can
affect one’s quality of life.
Peter Pan Syndrome is not currently
considered a psychopathology.
Symptoms - It is said that people who
develop behaviours of living life carefree,
finding responsibilities challenging in
adulthood and basically, “never growing up”
suffer from Peter Pan Syndrome.
It could affect one’s daily routine,
relationships, work ethic, and result in
attitudinal changes.
The affected people have body of an adult but
the mind of a child.
The syndrome can affect anyone, irrespective of gender, race or culture. However, it appears to be more common
among men.
5.49 Esotropia
There is a five-fold increase in children with acute onset of esotropia.
When an eye crosses inward, it is termed esotropia (“Eso” means to turn inward toward the nose.)
Intermittent crossing of an infant’s eyes under about 4 to 5 months is normal. However, constant crossing of
the eyes may be a concern.
Esotropia is a type of strabismus.It can occur in just one eye or alternate between both eyes.
It is rare for both eyes to cross in at the same time.
Three forms of esotropia - Congenital or infantile esotropia, Acquired strabismus and Microstrabismus.
5.53 Goitre
Prevalence of self-reported goitre in National Family Health Survey (NFHS) IV (2015-2016) was 2.2%, while it was
2.9% in NFHS-V (2019-2021).
Goitre may be an overall enlargement of the thyroid gland, or it may be the result of irregular cell growth.
The swelling of the thyroid gland forms one or more lumps (nodules) in the front of the neck. The lump will
move up & down when you swallow.
A goiter may be associated with no change in thyroid function or with an increase or decrease in thyroid
hormones.
Causes of goiter
1. Not enough iodine or lack of iodine in your diet (most common),
2. Hypothyroidism (Underactive thyroid),
3. Hyperthyroidism (Overactive thyroid),
4. An inflamed thyroid gland (thyroiditis),
5. Hormone changes during puberty, pregnancy or the menopause,
6. Taking some types of medicine, such as lithium, a medicine used to treat some mental health conditions,
7. Having radiation treatment to your neck or chest area,
8. Nodules or cysts within the thyroid,
9. Thyroid cancer.
Treatment depends on the cause of the goiter, symptoms, and complications resulting from the goiter.
Small goiters that aren't noticeable and don't cause problems usually don't need treatment. A wait-and-see
approach is usually recommended.
Other possible treatments include radioiodine treatment and thyroid surgery.
Thyroid gland
Thyroid gland is a butterfly-shaped gland located at the base of the neck just below the Adam's apple.
OTHERS
Issues
3. Persistent - PFAS remain in the environment for an unknown amount of time and may take years to
leave the body.
4. Bioaccumulation - Different PFAS chemicals may enter the food chain in various ways, gradually
accumulating and remaining in a body over time. This occurs due to more intake than excretion of the
chemicals.
Impacts - People are most likely exposed to these chemicals by consuming PFAS-contaminated water or food,
using products made with PFAS, or breathing air containing PFAS.
Health effects on humans include
1. Altered metabolism,
2. Fertility and reduced fetal growth,
3. Increased risk of being overweight or obese, and
4. Reduced ability of the immune system to fight infections.
5.60 Silicosis
Silicosis is ravaging mine and factory workers in several villages of Jharkhand.
Silicosis is a type of pulmonary fibrosis, a lung disease caused by breathing in tiny bits of silica, a common
mineral found in sand, quartz and many other types of rock.
It usually happens in jobs where you breathe in dust that contains silica.
[High-risk jobs are construction work, stone countertop fabrication, foundry work, ceramics manufacturing,
mining and hydraulic fracturing (fracking).]
Over time, exposure to silica particles causes scarring in the lungs, which can harm your ability to breathe.
Symptoms of silicosis usually appear after many years of exposure.
In early stages, symptoms are mild and include cough, sputum and progressive shortness of breath.
As the scarring continues to worsen, the first real signs of a problem may be an abnormal chest X-ray and a
slowly developing cough.
Complications from silicosis can include tuberculosis, lung cancer, chronic bronchitis, autoimmune disorders
and kidney disease.
Treatment - There is no cure for silicosis, but treatment is available, and employers and workers can take steps
to prevent it.
Medications (Inhaled steroids reduce lung mucus; Bronchodilators help relax your breathing passages; Oxygen
therapy)
Lung transplant surgery
Cigarette smoking adds to the lung damage caused by silicosis. Quitting smoking is an important part of
managing the disease.
6. BIO-TECHNOLOGY
Introduction
B cells and T cells are the White Blood Cells of the immune system that are responsible for adaptive immune
response in an organism.
Both B and T cells are structurally similar and originate in bone marrow.
Both the cells are non-phagocytic and are a part of lymphatic system.
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a gene editing technology.
It allows researchers to permanently modify genes in living cells and organisms by targeting specific stretches
of genetic code to edit DNA at precise locations.
This is done by introducing a protein (Cas9) containing the code of a defective gene.
The protein then seeks out parts of the defective DNA that match this code.
It then attaches itself to it, cuts it out, and then the DNA is allowed to repair itself by getting rid of the defect.
It can be used to target multiple genes simultaneously and can also activate gene expression instead of cutting
the DNA.
This can be used to correct mutations at precise locations in the human
genome to treat genetic causes of diseases.
Correcting the mutation in an embryo ensures that the child is born
healthy and the defective gene is not passed on to future generations.
Apart from being used as a gene-editing tool, CRISPR CAS-9 can also
function as a diagnostic tool.
It can recognise target DNA very quickly and identify viruses such as
Zika and dengue very efficiently.
When an alien bacteria or virus invades the body, CRISPR is
“programmed” to recognise the alien material. It then uses CAS-9, an
enzyme produced by the CRISPR system to bond with the alien DNA
and excise it.
Types of Sequencing
There are three generations of sequencing technologies -
1. First-generation sequencing (used in the 1970s and 1980s) - Maxam-Gilbert method, and Sanger
method (or dideoxy method),
2. Next-generation sequencing or NGS (used since the late 1990s)
Second-generation sequencing and
Third-generation sequencing.
Comparatively, the Next-generation sequencing technologies are able to process much higher volumes of DNA
at the same time, significantly reducing the amount of time it takes to sequence a genome.
Sanger sequencing involves cutting up DNA into short fragments and adding radioactive or fluorescent tags
to identify each nucleotide. The fragments are then put through an electric sieve that sorts them by size.
Compared with newer methods, Sanger sequencing is slow and can process only relatively short stretches of
DNA.
But it provides highly accurate data, and some researchers are still using this method to sequence SARS-CoV-2
samples.
Second-generation sequencing marks each nucleotide with a specific colour. These technologies are able
to read DNA directly.
After DNA is cut up into fragments, short stretches of genetic material called adapters are added to give each
nucleotide a different colour.
Finally, these DNA fragments are fed into a computer and reassembled into the entire genomic sequence.
Third-generation sequencing technologies like the Nanopore MinIon detect changes in an electrical current
to identify nucleotides.
As each pair of nucleotides disrupts the electrical current in a particular way, the sequencer can read these
changes and upload them directly to a computer.
This allows clinicians to sequence samples at point-of-care clinical and treatment facilities. However, Nanopore
sequences smaller volumes of DNA compared with other NGS platforms.
Recent Developments
Analogues
Nucleoside and nucleotide analogues are the two types of analogues.
They can be used in therapeutic drugs, include a range of antiviral products used to prevent viral
replication in infected cells.
Nucleoside analogues are nucleosides which contain a nucleic acid analogue and a sugar.
This includes any group of antiviral drugs that inhibit the viral enzyme reverse transcriptase and are used in the
treatment of HIV infection.
Nucleoside analog inhibitors compete with nucleotide substrate to bind to the active site of polymerase.
Once they are incorporated into the elongation chain of nucleic acid, chain termination results.
Similar to nucleoside analogues, Nucleotide analogues are nucleotides which contain a nucleic acid
analogue, a sugar, and a phosphate groups with one to three phosphates.
6.5 ASPAGNII
Department of Biotechnology- National Institute of Immunology (DBT-NII) receives ASPAGNII trademark for India’s
First Indigenous Tumour Antigen SPAG9. SPAG9 was discovered by Dr Anil Suri in 1998.
Currently, ASPAGNII is being used in dendritic cell (DC) based immunotherapy in cervical, ovarian cancer and
will be used in breast cancer.
Immunotherapy is a new approach that exploits the body’s inner capability to put up a fight against cancer.
With this approach, either the immune system is given a boost, or the T cells are “trained’’ to identify recalcitrant
cancer cells and kill them.
In this personalised intervention, those patients expressing SPAG9 protein can be treated with the DC-based
vaccine approach.
In DC-based vaccine, patient’s cells called monocytes are collected from their blood and modified into dendritic
cells.
The DCs are primed with ASPAGNII and are injected back to the patient to help the ‘fighter’ cells, or T-cells, in
the body to kill the cancer cells.
DC-based immunotherapy is safe, affordable and can promote antitumor immune responses and prolonged
survival of cancer patients.
About 50% of our genome has repetitive DNA that doesn’t code for protein. These are called 'junk DNA' or dark
matters of genome.
Their finding is based on a series of experiments that found that deleting the DNA sequence from cancer cells
caused telomeres to shorten, cells to age, and tumors to stop growing.
The length of the sequence ranged from as short as 53 repeats or copies of the DNA to as long as 160 repeats.
The study actually shows that the telomerase gene is more active in people with a longer sequence.
But, having a shorter sequence doesn’t necessarily mean shorter lifespan.
It means the telomerase gene is less active and your telomere length may be shorter, which could make you less
likely to develop cancer.
These findings tell that this VNTR2-1 sequence contributes to the genetic diversity of how we age and how we
get cancer.
Telomerase Gene
This gene controls the activity of the telomerase enzyme, which helps produce telomeres, the caps at the end of
each strand of DNA that protect the chromosomes within our cells.
In normal cells, the length of telomeres gets a little bit shorter every time cells duplicate their DNA before they
divide.
When telomeres get too short, cells can no longer reproduce, causing them to age and die.
However, in certain cell types - reproductive cells and cancer cells - the activity of the telomerase gene ensures
that telomeres are reset to the same length when DNA is copied.
This is what restarts the aging clock in new offspring but is also the reason why cancer cells can continue to
multiply and form tumors.
o Privacy issues - Sensitive genetic information of a person is exposed to another individual and it is
against human rights
o Security concerns - DNA databases holding DNA profiles
o Lack of expertise - Leads to mishandling of samples
o Intermixing of samples - Corruption, tampering with evidence, misconception during labeling
sample is possible
o Targeting of groups - If people from one ethnic group are more often convicted, they will be
overrepresented and leads to targeting
As a result, its newborn sucklings are exposed to a large load and variety of microbes.
An unusually potent antimicrobial protein, MLP (Monotreme Lactation Protein) found only in platypus
milk serves to protect its babies from pathogens.
Promote business - Studying the mammalian lactation can aid to build sustainable businesses in the vegan
milk sector.
Amongst the most ambitious approaches are the ones trying
to grow cell cultures of the mammary organs themselves to
secrete human and other mammalian milks.
Several start-ups are attempting to make “animal-free”
value-added dairy products and atleast one start-up is
trying to re-constitute human breast milk with critical
proteins made through synthetic biology.
Understanding the proteins - It helps scientists
understand how lactoferrin, a whey protein,
modulates in multiple ways thus promoting a beneficial gut
microbiome among infants.
Recently whey proteins have been produced using synthetic
biology techniques by relying on re-programming a type of fungus called Trichoderma.
The Vechur cow (now almost extinct), a dwarf cow, native to the Kuttanad region of Kerala yields milk
containing as much lactoferrin as human breast milk.
6.13 Xenobots
Scientists have witnessed a never-before-seen type of self-replication in world’s first living robots (xenobots) created
in the lab using frog cells.
Xenobots are synthetic life forms that are designed by computers to perform
some desired function and built by combining together different biological
tissues.
Xenobots are named after the African clawed frog (Xenopus laevis).
The world’s first Xenobots were developed in 2020 by assembling African
clawed frog cells.
These frog cells aren't genetically modified at all, but simply combined in
different arrangements to produce the xenobots.
The C-shaped Xenobots propel themselves by using tiny hair-like structures called cilia.
These “parent” Xenobots move around their environment, they collect loose stem cells in their “mouths”, over
time, aggregate to create “offspring” Xenobots that develop to look like their creators.
This reproduction happens at the molecular level, and there is no other organism that reproduces or replicates
in this way.
But, the idea of kinematic self-replication is not entirely new - it was first suggested in the late 1940s by
mathematician John von Neumann.
Benefits - One day these xenobots could be programmed to perform useful functions such as finding cancer
cells in the human body or trapping harmful microplastics in the ocean.
Dark genome is a vast space, accounting for the ~98.5% of genomic space where repeat elements, enhancers,
regulatory sequences, and non-coding RNAs reside.
It comprises the DNA outside our genes. These are the regions, not classed as genes in the traditional sense,
which create proteins.
Study - The scientists say that these new proteins can be used as biological indicators to distinguish between
the two conditions - schizophrenia and bipolar disorder.
It can also be used to identify patients more prone to psychosis or suicide.
Related Links - Genome India Project
6.16 Nutraceuticals
Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP) Kendras have added to its product basket, nutraceuticals
like protein powder and bar, malt-based food supplements and immunity bar for its customers.
The term “nutraceutical” combines two words “nutrient” (the nourishing food component), and
“pharmaceutical,” (which is a medical drug).
The name was coined in 1989 by Stephen DeFelice.
Nutraceuticals is a broad umbrella term that is used to describe any product derived from food sources with
extra health benefits in addition to the basic nutritional value found in foods.
Nutraceuticals are food or part of food that provides medical or health benefits including the prevention
and/or treatment of a disease.
A nutraceutical product may be defined as a substance, which has physiological benefit or provides protection
against chronic disease.
Nutraceuticals may be used to improve health, delay the aging process, prevent chronic diseases, increase life
expectancy, or support the structure or function of the body.
Recent studies have shown promising results for these compounds in various complications.
Emphasis has been made to present herbal nutraceuticals effective on hard curative disorders related to
oxidative stress including allergy, alzheimer, cardiovascular, cancer, diabetes, etc.
Functional Foods
Functional foods are foods that have a potentially positive effect on health beyond basic nutrition.
Proponents of functional foods say they promote optimal health and help reduce the risk of disease.
Examples - Oatmeal (because it contains soluble fiber that can help lower cholesterol levels); Orange juice
that's been fortified with calcium for bone health.
Traits - Its elongation after cooking - a trait that is the second major determinant of prices in the international
market - is also greater.
In addition, great head rice recovery after polishing (unbroken grains that can then be marketed) adds to its
profitability.
Kalanamak is a successful adapter to usar soils characterised by higher salt concentration and high pH.
It is also highly resistant to notorious, and in India common, rice diseases such as panicle blast, stem rot and
brown spot. Bacterial blight is quite rarely observed.
It is drought tolerant. It is normally grown under rain-fed conditions and in uplands. Water requirement is quite
low as compared to basmati.
Kalanamak is traditionally grown using no fertiliser, herbicide and pesticide, which makes it suitable for organic
cultivation.
7. NUCLEAR TECHNOLOGY
It includes the contributions of several countries, including India, South Korea, Japan, Russia and the United
States.
To know more about International Thermonuclear Experimental Reactor (ITER), click here.
8. INNOVATIONS
8.1 AmbiTAG
Indian Institute of Technology, Ropar has developed a first-of-its-kind IoT device called AmbiTag (Available at the
production cost of Rs. 400).
AmbiTag records real-time ambient temperature during the transportation of perishable products (like
vegetables, meat and dairy products), vaccines (like COVID vaccine), body organs and blood.
It generates an alert when the temperature goes beyond a pre-set limit.
That recorded temperature further helps to know whether that particular item transported from anywhere in
the world is still usable or perished because of temperature variation.
Shaped as USB device, AmbiTag continuously records the temperature of its immediate surroundings from -40
to +80 degrees in any time zone for a full 90 days on a single charge.
The device has been developed under IIT Ropar Technology Innovation Hub - AWaDH (Agriculture and Water
Technology Development Hub) and its Startup ScratchNest. AWaDH is a Govt of India project.
8.4 Viscose
It is a semi-synthetic material or manufactured fiber used in clothes, upholstery and other bedding
materials.
It’s one of the three types of rayon - modal, lyocell, and viscose.
It is made from natural materials like wood pulp, which is treated and spun into yarns to make fabric.
Viscose was manufactured as an affordable alternative to natural silk, hence known as artificial silk.
In India, it is largely used to make apparel for women and children.
Viscose products are seen as easy to maintain too and viscose consumption in India has witnessed 11% CAGR
for the last 5 to 6 years.
8.10 Aquamation
The body of Nobel Peace Prize winning Anglican archbishop and anti-apartheid campaigner Desmond Tutu
underwent aquamation.
Also known as water cremation, green cremation or chemical cremation or alkaline hydrolysis, Aquamation is
a “flameless cremation” process that involves of cremation by water rather than fire.
Aquamation is a process in which the body of the deceased is immersed for 3 to 4 hours in a mixture of water
(95%) and a strong alkali (5%) in a pressurized metal cylinder and heated to around 150 degree centigrade.
The combination of gentle water flow, temperature and alkalinity in this process accentuate the breakdown of
the organic materials.
The decomposition that occurs in alkaline hydrolysis is the same as that which occurs during burial, just sped
up dramatically by the chemicals.
Resultant - The process liquifies everything, and leaves behind bones and a neutral liquid called effluent.
Bones are then dried with the help of an oven and reduced to white dust.
Effluent is sterile, and contains salts, sugars, amino acids and peptides. There is no tissue and no DNA left after
the process completes.
This effluent is discharged with all other wastewater, and is a welcome addition to the water systems.
History - The process of Aquamation was developed and patented in 1888 by Amos Herbert Hanson, a farmer
who was trying to develop an ingenious way to make fertilizer from animal carcasses.
The first commercial system was installed at Albany Medical College in 1993. Thereafter, the process continued
to be in use by hospitals and universities with donated body programmes.
Benefits - The process of aquamation uses energy which is 5 times less than fire.
It also reduces by about 35% the amount of greenhouse gases that are emitted during cremation.
The process is a greener alternative to the traditional cremation methods as it uses significantly less fuel and
has an overall lower carbon footprint than traditional methods.
Legality - Aquamation was introduced in South Africa in 2019. It is authorized in only a few countries.
Developing large-scale perovskite solar cells requires high-quality defect-free perovskite films with improved
surface coverage.
But, perovskite materials are extremely unstable towards ambient (humidity and oxygen) conditions that
restrict their commercialisation.
Stabilisation - The most convenient way to harness the maximum potential of the perovskite active layer is to
use a coating of an appropriate passivation material.
This will make the perovskite active layer ‘stable’ or less readily affected by the environment, in this case
humidity and oxygen.
Perovskite-based solar cells can be manufactured at room temperature, making them cost-effective and
more eco-friendly.
As the all components used in the hybrid perovskite-based solar cells are recyclable, they will help reduce the
growing problem of Waste Electrical and Electronic Equipment (WEEE).
An International Renewable Energy Agency (IRENA) report estimated the global PV waste will touch 78 million
tonnes by 2050, with India being one of the top five PV waste creators.
8.13 Aluminium
The Indian Railways (IR) plans to use Aluminium to produce body coaches in the new generation energy efficient
Vande Bharat Train sets.
Aluminium (Al) is a highly electropositive metal with the atomic number of 13.
Among metals, aluminium is the most abundant. It is the third most abundant element in earth’s crust (8.3%
approx. by weight).
It is a major component of many igneous minerals like mica and clays.
Properties - Even though Aluminium is a metal, it shows many chemical similarities to boron, a non-metal.
It has high tensile strength, high electrical and thermal conductivity.
Extraction - For the purpose of extraction, Bauxite (Al2O3. 2H2O) and Cryolite (Na3AlF6) are chosen for
aluminium.
9. IT & COMPUTER
No single system controls the ledger and instead, a decentralized network of computers keeps a blockchain
running and authenticates its transactions.
Bitcoin and other cryptocurrencies are essentially codes recorded on a blockchain that gets longer and longer as
more people use them.
Cryptocurrencies Transactions
Buying it from someone – It usually happens in two ways
1. An exchange-facilitated transaction
2. A peer-to-peer transaction
Cryptocurrency exchanges are platforms that broker the trading of cryptocurrencies for other assets, including
digital and fiat currencies.
They are independent and operate just like stock exchanges do globally.
Cypto exchanges operating in India include WazirX, CoinDCX, CoinSwitch Kuber, Zebpay, Bitbns, Giottus, etc.
Peer to peer (P2P) trading is the act of buying and selling cryptocurrencies directly between users without a
third party or intermediary.
Mining new cryptocoins - Mining is a process of creating new crypto coins by solving complex mathematical
equations.
The transactions using cryptocurrency is complete only when a “miner” verifies the transaction as legitimate.
This verification process requires miners to solve complex equations and those who do that first are paid a
fraction of the transaction as a fee for their effort.
The Indian exchanges allow sale of cryptocurrencies in exchange for INR as well.
But many of the smaller banks that support the transactions do not have the necessary digital infrastructure to
handle the volumes of withdrawal.
The volatility experienced by these virtual currencies and disruption in withdrawal services is a common
occurrence.
Pros of cryptocurrency
Potential for high returns
Transparency
No chance of personal information leakage
Immediate and secure ownership transfer
Potential diversification
Instantand 24 hour accessibilty
Cons of cryptocurrency
Illegal activities can be performed
Loss risk is high
Cryptocurrency market is highly volatile
Poor store of value and limited acceptance
Difficult to comprehend
Challenges of market fluctuations
Available Alternatives
Stablecoins are a type of cryptocurrency that offer more stability than other cryptos because they are backed by
assets.
Their market value is pegged to some external reference such as the US dollar thus giving it an intrinsic value.
Stablecoins achieve their price stability via collateralization or through algorithmic mechanisms of buying and
selling the reference asset or its derivatives.
Most of the sovereign governments push for stablecoins such as Tether, USD Coin and Diem (proposed by
Facebook’s parent company Meta) as it could increase the reach of the fiat currencies in the digital ecosystem.
Stablecoins attempt to bridge the gap between fiat currencies and cryptocurrencies and there are three
categories of stablecoins.
Fiat-Collateralized Stablecoins - These stablecoins use a specific amount of a standard fiat currency, like
the US dollar, as collateral to issue crypto coins.
Other forms of collateral can include precious metals like gold and silver and commodities like oil.
Tether (USDT) and TrueUSD are popular crypto coins that are backed by dollar deposits.
Crypto-collateralized stablecoins - Here the underlying collateral is another cryptocurrency instead of a
tangible commodity or a fiat currency.
An example of crypto-backed stablecoin is dai, which is pegged to the U.S. dollar and runs on the Ethereum
blockchain.
Algorithmic Stablecoins - These stablecoins use a computer algorithm to keep the coin’s value from
fluctuating too much.
Risk in Stablecoins - The credibility of stable coins such as tether has been the subject of controversy because
the issuer of the coins may not actually hold fiat currencies against the tether or may not hold them in sufficient
quantities.
The providers promise they have reserves worth 100% of the value of their stablecoins, but that’s not quite
accurate.
A large part of the assets are based on commercial paper and is not cash equivalent thereby posing a solvency
risk in the event of a sudden collapse in the value of these assets.
Another issue is the e-dollarisation as most stablecoins are likely to be pegged to the US dollar.
The US might actually see that as an advantage to strengthen the reach of the dollar which in turn disincentivises
the regulation of stablecoins.
Gifting- The term ‘property’ under the IT Act is being expanded to include virtual digital assets so that such
assets received as a gift shall be taxable except when received from relatives.
Gifts of virtual digital asset will now be taxable at 30% in the hands of the recipient. However, gifting to the
close relative which includes wife or children, is not liable to tax.
Enforcement- The new virtual digital asset tax comes into force on April 1, 2022.
The trading profits will be taxed at, according to crypto industry players, a higher rate compared to other
jurisdictions.
Off losses- No deductions will be allowed on account of setting off losses from such trading or from any other
capital losses and the only deduction permitted would be the cost of acquiring the asset.
o For instance, if you have invested Rs 1 lakh in crypto and sold for Rs 1.5 lakh, then only the gain of Rs
50,000 will be taxed without any other deduction.
Legitimacy- The taxation regime by itself, does not grant legitimacy to the trade in these currently unregulated
assets and a consultation process is underway, which will determine the legal position of such assets.
Significance - The Budget proposals aim to tax both the transfer and sale of virtual assets.
Exchanging a Bitcoin for an Ethereum is covered within the definition of transfer, whereas, sale of cryptocoin
involves normal cash or currency.
Though the Government may still not consider them fully legitimate, the tax regime indicates the hard option
of an outright ban that was signalled in the proposed crypto law last year.
It also solves the concerns of being lured by crypto players’ misleading ads, with no norms brought in place, and
no regulatory watch.
The Government had also indicated a forward-looking approach to crypto market oversight.
Concerns –
Lack of clarity- There rises a question of whether transferring my coin between my own wallets is taxable
or not.
We need to get more clarity with respect to what they mean by transfer.
No set-offs- No set-offs will be allowed on losses incurred in the transfer of virtual assets.
This means losses or profits of crypto cannot be adjusted with any other income or losses in the current
financial year and losses cannot be carried forward to the next year.
Heavy taxation- Virtual assets are now taxed so highly that only the rich can afford to invest in crypto.
Delay- The delay in arriving at a decision prevents Indian start-ups and innovators from developing
products and ideas that can be scaled up globally given the nature of these assets.
Gaming coins- Gaming coins such as Axie Infinity and Enjin Coin are in-game cryptocurrency which may be
used for the purchase of in-game assets.
These gaming coins may be purchased from crypto exchanges or be acquired as winnings in games that have
adopted the play-to-earn model.
Status in India - Since blockchain is merely the underlying technology, there is no express regulation of it in
India.
However, it would be suitable to explore the legality of the games from the lens of existing Indian gaming
regulation.
Games of skill vs. games of chance- The Supreme Court recognized that no game is purely a ‘game of skill’
and almost all games have an element of chance.
A ‘dominant element test’ is to be utilized to determine whether chance or skill is the dominating element in
determining the result of the game.
The dominant element may be determined by factors such as superior knowledge, training, experience, expertise
or attention of a player have a material impact on the outcome of the game.
Staking money or property on the outcome of a ‘game of chance’ is prohibited and subjects the guilty parties to
criminal sanctions but staking on the outcome of a ‘game of skill’ is not illegal per se and may be permissible.
Common gaming house- Owning or keeping or being present for the purpose of gaming in a common gaming
house is ordinarily prohibited in terms of the state gaming laws.
Courts have clarified in the past that the mere charging of an extra fee to facilitate playing the game or to
maintain the facilities may not necessarily be seen as making a profit or gain.
Other than states such as Sikkim, Nagaland, and Telangana, which recognize online gaming, in most states and
union territories, there is currently a lacuna in gaming law.
It can be inferred that each blockchain game must first pass as a ‘game of skill’, as against a ‘game of chance’, to
legally be made available in most Indian states.
The Supreme Court has rejected the video games being ‘games of skill’, as the outcomes of these games could be
manipulated by tampering with the machines and the skill of players could not be a dominant factor of the game.
Delhi District Court has held that a gaming portal would be covered within the definition of a ‘common gaming
house’, if it were to take commission / earn revenue from the game offered.
In 2021, the Finance Ministry has announced that the Cryptocurrency and Regulation of Official Digital
Currency Bill, 2021, was to be tabled in the Parliament that seeks to prohibit all private cryptocurrencies.
If the legislature does indeed successfully place a ban on private cryptocurrencies, then, the existing blockchain
games relying on cryptocurrencies would be considered illegal in India.
Also, it was announced in Budget Speech that the income from the transfer of any ‘virtual digital assets’ would
be subject to income tax at the rate of 30%.
Intellectual property protections to blockchain games
Patents- For a blockchain game or any of its elements to be patented in India, it will need satisfy the
patentability requirements of:
o being a new product or process (having novelty)
o involving an inventive step (having a feature that involves technical advancement or having economic
significance or both)
o being capable of industrial application
In terms of Section 3(k) of the Patent Act, 1970, computer programs are per se not inventions and hence, cannot
be patented.
However, judicial pronouncements have clarified that if an invention has a technical contribution or a technical
effect then it would be patentable.
The Office of the Controller General of Patents, Designs and Trade Marks has issued the CRI Guidelines, stating
that ‘databases’ would be considered computer programs and are not patentable.
Game developers or publishers may seek patent protection for any element of the game (such as its game play
method) which has led to technological advancement as in case of the US.
Trademarks - A trademark is used as an identifying mark to determine the source of a particular good or
service, and is obtained to protect the goodwill and reputation of the brand.
Any distinguishing mark in a blockchain game or NFT may be trademarked.
In India, certain underlying aspects of the blockchain game may be trademarked, including
o the name of the game
o a tag line attached to it
o the logo of the game
o the character names in the game
o the name of the in-game currency (similar to the trademark for the name ETHEREUM in the US)
If the inventor of an NFT decides to give proprietary names to their own tokens, then such names may be
protected as trademarks.
Copyrights- In India, artistic work, musical work, cinematographic films, dramatic works, sound recordings
and computer software are capable being of being protected under copyright law.
Although there is no specific provision in the Copyright Act that deals with video games, copyright protection of
video games may be sought under the category of ‘multimedia products’.
Certain aspects of blockchain games, such as the artwork and sounds used in the game as audiovisual work along
with the underlying source code as a literary work can be copyrighted.
Prevention - Zero-click attacks are hard to prevent as it is harder to detect. Detection becomes even harder in
encrypted environments where there is no visibility on the data packets being sent or received.
One of the things users can do is to ensure all software and operating systems are up to date so that they would
have the patches for at least vulnerabilities that have been spotted.
Also, the apps shouldn’t be sideloaded and should be to downloaded only via Google Play or Apple’s App Store.
It is even more secure to stop using apps altogether and switch to the browser for checking mails or social media,
even on the phone.
These immersive simulations can create almost any visual or place imaginable for the player using special
equipment such as computers, sensors, headsets, and gloves.
Merged Reality
Merged Reality or Mixed Reality is when the real and virtual world are merged and objects from both can
interact.
For example, Intel’s Project Alloy uses mixed reality to allow people to use their real hands in the virtual world.
Before this point, users had to hold controllers that represented their hands.
ut, network experts said that the outage was due to an update to Border-Gateway Protocol (BGP).
Facebook is a network, which advertises its presence to
other networks. This enables Internet service providers
across the world to route web traffic to different networks
via BGP process.
In the case of Facebook, an update to the BGP removed
its online properties from being available to world’s
computers.
Any time a change made to a network’s BGP, be it an
announcement or withdrawal, a message is sent to a router
informing the update.
It was found that the route withdrawals from Facebook
made its Domain Name System (DNS) servers offline. So,
the social network’s DNS was not accessible to other
networks, and the Internet.
When a DNS resolver fails to translate a domain name into an IP address, people won’t be able to access that
specific website.
As a direct consequence, the webpage won’t load. This is what happened in the case of Facebook.
Web3 applications sometimes referred to DApps are built on decentralised peer-to-peer networks like Ethereum
and IPFS.
Instead of being run by some tech giants companies, these networks are built, operated, and maintained by
users.
It is possible to split up large files into smaller chunks.
It can be individually encrypted and stored in other locations, making it nearly impossible to hack.
User Friendly - Any change in personal data like your address or credit card number needs to be changed
once on your end.
Automatically all your sites will be updated. This will make the Web much more user-friendly.
They aren’t subject to the business hours of mainstream financial institutions.
Web3 allows for low-cost, nearly instantaneous, borderless, peer-to-peer transfers of actual value.
Innovations - Centralisation helped billions of people get access to amazing technologies (mostly free to use),
but it has stifled innovation.
Companies that own networks have unilateral power over who gets network access, how revenue is divided,
what features are supported, etc.
That makes it harder for start-ups, creators and other groups to grow their internet presence.
Decentralising the web removes these hurdles for new start ups.
Recent applications of Web3.0
The applications are much larger and wilder. It is growing beyond its financial origins such as cryptocurrency.
Web3 will power the new financial world order on metaverse.
It is different from reality but is built by taking inspiration from the real environment around us.
It will unleash innovation in online gaming, tokenisation of assets in virtual spaces.
Some of the use cases of Web3 are Decentralised Autonomous Organisations (DAOs), Decentralised Finance
(DeFi), Stablecoins and Central Bank Digital Currencies (CBDCs), private and digital infrastructure, and creator
economy enablers like NFTs and blockchain-based games.
9.13 5G Technology
Lava International becomes the first Indian brand to launch 5G smart phone under the brand name 'Agni' for domestic
consumers.
5G is the fifth-generation wireless
technology that operates in
the millimeter wave spectrum (30-
300 GHz).
It is the latest upgrade in the long-
term evolution (LTE) mobile
broadband networks.
5G mainly works in 3 bands, namely
low, mid and high frequency
spectrum.
Pros of 5G - 5G can provide higher
speed (20 Gbps speed), lower
latency and greater capacity than 4G
LTE networks.
It increases more bandwidth that
will help transfer the data as soon as
possible. Less tower congestion.
Cons of 5G - Limited global coverage, decreased broadcast distance, the upload speeds are not over 100 Mbps
when compared to 4G, weakened device batteries, lack of early encryption in the connection process, etc
9.14 6G
Minister for Communication said that the 6G development has already started. That will be seen somewhere in the
time frame 2024 or 2023-end.
Wireless generations (G) are standardized by the International Telecommunication Union (ITU) and occur
every 10 years or so.
They're generally marked by a break in the "air interface," meaning a change in transmission or encoding.
This is done so previous-generation devices can't be upgraded to the new generation.
6G is the sixth generation of wireless communication and networking technology. It is a mostly theoretical
concept.
It is built upon the infrastructure of 5G, and will accomplish more than 5G in terms of adoption, reduction of
cost, and better service.
While 5G provided less than 1ms latency, 6G provides less than 0.1ms latency.
6G will operate on the mid bands (7 – 20 GHz) for places that are crowded, low bands (460 – 694 MHz) for
long-distance coverage, and use sub-THz for peak data rates in the short range of up to 100 Gbps.
6G will also used significantly advanced network devices, including MIMO (multiple input, multiple output)
antennaes.
While 4G uses 2x2 MIMO and 4x4MIMO, and 5G uses around 200 antenna elements, 6G may support upto
1024 antenna elements.
Characteristics - Higher speed than 5G, horizontal foundation of various industries in a society, high latency,
etc
6G will be a collection of the heterogeneous networks, like cellular networks covering large outdoor space;
WiFi for indoor or low-speed outdoor use, satellite networks such as low earth orbit constellation.
It is part of “edge computing,” which moves network management away from centralized clouds towards
more localized devices, making everything work way smoother and reducing response times.
Benefits - The important areas that will benefit from this technology are the likes of smart devices and self-
driving cars.
6G will also be beneficial to the advancement of Artificial Intelligence and Machine Learning.
Availability in India - Now, VSAT operators offer satellite broadband services at a very limited capacity in
India in a few remote locations.
The utilisation of satellite services is restricted to minimal applications - such as disaster management, defence,
scientific locations, etc.
Key hurdles are high latency of these services, which means that real-time transmission is hard.
But this hurdle can be overcome with the ISRO’s high throughput Geostationary Equatorial Orbit (GEO)
satellites, which can beam high-speed internet up to 300 gigabytes per second.
The launch of the constellation of Low earth orbit (LEO) satellites very close to the earth’s surface will reduce
the latency of satellite broadband.
Example - Elon Musk’s Starlink, Sunil Bharti Mittal backed OneWeb and the Canadian satellite major Telesat.
Related Links - Internet from the Sky
The flaw can be exploited either over HTTP or HTTPS (the encrypted version of browsing), which adds to the
problems.
9.20 Doxxing
Meta’s oversight board suggested that Facebook and Instagram must make strict doxxing rules.
Doxxing is publishing and analysing others' personal information on the internet with a malicious intent that
can reveal the person's real identity making them victims of harassments and cyber attacks.
Generally, doxxing is used to shame or punish people who would rather stay anonymous, because of their
controversial beliefs or other types of non-mainstream activity.
The term doxxing (sometimes spelled doxing) is a longtime hacker term derived from “dropping dox” or
documents about an adversary.
Motivations range from personal revenge to political ends.
Some doxers act with the intent of exposing criminals or perpetrators of heinous acts.
However, there are plenty of examples of people who have been wrongly doxxed and harmed as a result.
Purpose - The main purpose of M2M technology is to tap into sensor data and transmit it to a network.
Unlike SCADA or other remote monitoring tools, M2M systems often use public networks and access methods
- cellular or Ethernet - to make it more cost-effective.
Components - The main components of an M2M system include sensors, RFID, a Wi-Fi or cellular
communications link, and autonomic computing software programmed to help a network device interpret data
and make decisions.
These M2M applications translate the data, which can trigger preprogrammed, automated actions.
Artificial intelligence and machine learning facilitate the communication between systems, allowing them to
make their own autonomous choices.
Uses - M2M technology helps remotely monitor equipment and systems.
It reduces costs by minimizing equipment maintenance and downtime.
It was first adopted in manufacturing and industrial settings, where other technologies, such as and remote
monitoring, helped remotely manage and control data from equipment.
M2M has since found applications in other sectors, such as healthcare, business and insurance.
RSC is a powerful supercomputer that can perform tasks like translating text between languages and help
identify potentially harmful content on Meta's platform.
It can run computer vision workflows up to 20 times faster.
It can train large-scale Natural Language Processing (NLP) models three times faster.
It can help its researchers build better AI models that can work across different languages, seamlessly analyse
text, images and video together.
It also power real-time voice translations to large groups of people speaking different languages so that they can
collaborate on a research project, and develop new augmented reality tools.
With the pandemic, the demand for data centres of AI and ML among Government and educational entities is
witnessing exponential growth which in turn is boosting the demand for supercomputers.
RSC can keep people safe in the metaverse through its training models that can detect harmful content faster
than earlier systems.
Challenges - To fully realise the benefits of advanced AI self-supervised learning of various domains will
require training large and complex models for critical use cases like identifying harmful content on Meta's
platform.
Computer vision needs to process larger, longer videos with higher data sampling rates.
Speech recognition needs to work well even in challenging conditions with a lot of background noise and needs
to understand more languages, dialects, and accents.
There are large-scale scientific problems that need the right level of depth, accuracy and speed which cannot be
handled with the current generation of supercomputers.
It is a Visible Light Communications (VLC) system that has components such as,
o Solid-state lighting (SSL) such as LED bulbs,
o Photo-detector (photodiode) to receive light signals and
o Signal processing element to convert the data (embedded in the light beam) into ‘stream-able’ content.
Data is fed into an LED light bulb (with signal processing technology). Then the LED bulb sends data at rapid
speeds to the photo-detector.
Uses - LiFi systems provide ultra-fast, safe and cheap data connections.
They are chiefly useful in urban areas where radio spectra are congested.
They are also very useful in rural areas wherein Fiber Optic Cables or networks are not reachable.
Specialty - LiFi can be up to 100 times faster than Wi-Fi.
10.1 Nanofibers
Researchers at Massachusetts Institute of Technology have constructed small molecules which when added with
water form nanofibers.
These hard and rigid molecules become so tough that they it can hold about 200 times their own weight.
Nanofibers are fibers with diameters in the nanometer range.
They can be generated from different polymers and hence have different physical properties and application
potentials.
The diameters of nanofibers depend on the type of polymer used and the method of production.
10.2 Nanosniffer
It is the world’s first Microsensor based Explosive Trace Detector (ETD) developed by an Indian Institute of
Technology (IIT) Bombay incubated startup called NanoSniff Technologies.
Its core technology is protected by patents in the U.S. & Europe.
Nan oSniffer is an advanced, affordable and a 100% Made in India product in terms of research, development
& manufacturing.
It will reduce dependency on imported ETD devices.
Spintronics or spin electronics, in addition to its fundamental electronic charge, in solid-state devices offer to
harness electron spins.
[Spintronics is the study of the intrinsic spin of the electron and its associated magnetic moment.]
Spin-waves were efficiently transferred through these nanochannels, and this could be switched ‘ON’ and ‘OFF’
and its magnitude altered by a meagre voltage of few volts.
Significance - These reconfigured nanochannels can eliminate unwanted energy waste and promise wave-
based computing.
The collective precession can carry information encoded in its amplitude, phase, wavelength, and frequency
without any physical motion of particles, eliminating unwanted energy waste.
These nanochannels can be engineered further to transfer specific bands of frequencies through designed
parallel channels towards development of on-chip multiplexing devices.
10.6 Nanoantenna
Researchers have developed a nanoantenna made of DNA and polyethylene glycol (PEG) to study changes in the
structure of protein molecules.
Working - The DNA-based nanoantenna works like a two-way radio that can both receive and transmit radio
waves.
It receives light in one wavelength.
It transmits light in another colour depending upon the protein changes it senses, and this can be detected and
studied.
Characteristics - These fluorescent nanoantennae remained stable at higher temperatures.
These nanoantenna offer a distinct advantage over the fluorescent dyes that are ubiquitously used in
biotechnology.
The latter ‘display a low affinity for proteins’, while these nanoantennae have an affinity to a specific region of a
protein, which is contingent on the structure and chemistry of the protein.
So, they are able to detect even the most minute of changes.
The nanoantenna was able to pass muster even with respect to protein-protein interactions.
This nanoantenna can be synthesised with different lengths and flexibilities to optimize their function.
Significance - The antenna will help us understand how natural nanomachines function or malfunction,
consequently leading to disease.
Labs equipped with a conventional spectrofluorometer, could readily employ these nanoantenna[e] to study
proteins.
This study will in turn help us identify new drugs or to develop new nanotechnologies or nano-machines.
The antenna performed well when used for examining enzyme kinetics i.e. the speed at which a reaction
But for use of neon gas in the semiconductor industry, the gas has to reach 99.99% purity levels which make it
a rarity.
Palladium- Palladium is used to coat electrodes that help control flow of electricity.
It is also used in plating of microprocessors and printed circuit boards which is an essential process of chip
making.
Constraints - A typical semiconductor value chain includes strong research and development followed by
design, production, assembly, testing and distribution and logistics network.
Several supply-side constraints inhibiting its local manufacturing include
o Inadequate availability of ultra-pure and clean water and clean sand used for growing wafers
o Uninterrupted quality electricity supplies
o Controlled pollution free environment, etc.
Inadequate logistics and absence of proper waste disposal have further exacerbated the poor state of its
production.
Heavy investments into establishing production lines both in terms of capital and gestation period do not
encourage private players to venture into it.
11.3 Graphene
The Kerala government announced the country’s first Graphene Innovation Centre, a joint venture of Digital
University of Kerala, Centre for Materials for Electronics Technology (C-MET) and Tata Steel Limited.
Graphene is a single layer or monolayer of carbon atoms, tightly bound in a hexagonal honeycomb lattice.
It is an allotrope of carbon in the form of a plane of sp2-bonded atoms with a molecular bond length of 0.142
nanometres.
The separate layers of graphene in graphite are held together by van der Waals forces, which can be
overcome during exfoliation of graphene from graphite.
Characteristics - Graphene is
1. The thinnest compound known to man at one atom thick,
2. The lightest material known (with 1 sq. M. weighing 0.77 mg),
3. The strongest compound discovered (due to the very strong covalent bonds),
4. The best conductor of heat at room temperature,
5. The best conductor of electricity known and
6. High melting and boiling points.
These have an intelligent braking system with power regeneration for better energy efficiency thereby making
it cost, energy and environment efficient.
The current version of the train has 16 coaches with 14 ordinary chair cars and two executive class chair cars.
12. AWARDS
In asymmetric catalysis, two different molecules are built, in which each molecule is a mirror image of the other
one.
Using Organocatalysis, researchers can now more efficiently construct anything from new pharmaceuticals to
molecules that can capture light in solar cells.
Catalysts
Catalyst is any substance that increases the rate of a reaction without itself being consumed.
Enzymes are naturally occurring catalysts responsible for many essential biochemical reactions.
Catalysts are categorized into,
1. Homogeneous catalyst - Reaction mixture and catalyst both are present in the same phase. (e.g.):
Brønsted and Lewis acids, transition metals, organometallic complexes, organocatalyst.
2. Heterogeneous catalyst - Catalysts exist in a different phase than the reaction mixture.
3. Biocatalysts - Natural proteins (enzymes) or nucleic acids (RNA or DNA or ribozymes) used to
catalyze specific chemical reactions outside the living cells is called biocatalysis.
Organic catalysts
They have a stable framework of carbon atoms, to which more active chemical groups can attach.
These often contain common elements such as oxygen, nitrogen, sulphur or phosphorus.
This means that these catalysts are both environmentally friendly and cheap to produce.
Catalysis - Examples
Homogeneous catalysis - Carbonylation, oxidation, hydrocyanation, metathesis, and hydrogenation.
Heterogeneous catalysis - Haber-Bosch process for the synthesis of ammonia, Fischer–Tropsch process to
produce hydrocarbons.
13. OTHERS
The electrocatalytic materials - cobalt-oxide nanocubes - are dispersed over hard-carbon based nanostructured
carbon florets.
o This material was developed with the support of the Department of Science & Technology’s Material for
Energy Storage program.
Advantages - This route forms a system that doesn’t require the constant presence of the external magnetic
field and is able to sustain the magnetisation for prolonged time periods.
The enhancements achieved are 650% increase in current density, 19% lowering of energy required and a 3-fold
increase in volumetric hydrogen production rate.
This route can be directly adopted in existing electrolysers with external magnets without any change in design
or mode of operation.
[Electrolysers use electricity to break water into hydrogen and oxygen.]
One-time exposure of magnetic field for 10 minutes is enough to achieve the high rate of hydrogen production
for over 45 minutes.
3. It needs to be stored in sub-zero temperatures immediately after production and throughout its supply
chain.
Uses – It is highly nutritious and a good antioxidant. It helps women
with fertility issues.
Standards - It meets the ISO-prescribed standards imposed by the
Food Safety and Standards Authority of India in 2019.
It is based on the concentration of moisture, sugars, protein and
Hydroxy acids with 10 carbon atoms (10 HDA), a fatty acid found in
the jelly.
Presently, country specific standards are available only in Switzerland,
Bulgaria, Brazil and Uruguay.
Indian royal jelly is been found as better in quality than jelly produced
from Thailand and China and almost same as the Italian royal jelly.
Taproot impacts the bitcoin network’s ability to process more smart contracts, making it a little more
competitive with Ethereum.
Taproot increases privacy by obscuring what type of transaction is being executed.
Taproot improves the Bitcoin network’s efficiency by drastically reducing the volume of data required to be
stored on-chain to complete complex transactions.
More flexible transaction types and lower costs may support more development of Decentralized Finance (DeFi)
and Non-fungible Tokens (NFTs) on bitcoin.
13.7 Anti-Doping
National Dope Testing Laboratory (NDTL) regains the World Anti-Doping Agency (WADA) accreditation.With this,
NDTL’s Anti-Doping testing and activities will be resumed with immediate effect.
Doping is defined by the International Olympics Committee (IOC) as, ‘the use of any method or substance that
might harm the athlete, in a quest to gain an unfair advantage, over his or her fellow competitors’.
Doping are the performance enhancing drugs and dietary supplements that have been around since the ancient
Olympic Games.
These drugs are considered helpful to improve athletic performance.
The use of banned drugs by athletes is referred to as ‘doping’.
Types of Doping
o Performance enhancing substance (Stimulants, Anabolic Steroids, Peptide hormones, Beta-2 Agonist,
Narcotics, Diuretics, and Cannabinoids)
o Physical methods (Blood doping and Gene doping)
Blood doping is the process of increasing the Red blood cells by blood transfusion.
It increases haemoglobin allows higher amount of Oxygen to fuel an athlete’s muscles. This can improve stamina
and performance, particularly in long distance events.
Gene doping is the non-therapeutic use of cells, genes, genetic elements or of the modulation of gene
expression, having the capacity to improve athletic performance.
Anti-doping means opposing or prohibiting illegal doping to improve athletic performance.
Anti-doping authorities state that using performance-enhancing drugs goes against the ‘spirit of sport’.
Related Links - Human Growth Hormone, Court of Arbitration for Sport
World Anti-Doping Agency
The World Anti Doping Agency (WADA) is a foundation created through a collective initiative led by the
International Olympic Committee (IOC).
Established in 1999 as per the Lausanne Declaration on Doping in Sport, the WADA is an international
independent agency composed and funded equally by the sport movement and governments of the world.
It was found to promote, coordinate and monitor the fight against drugs in sports.
Its key activities include scientific research, education, development of anti-doping capacities, and monitoring
of the World Anti-Doping Code.
This Code is the document harmonizing anti-doping policies in all sports and all countries. The provisions of
this Code are enforced by the UNESCO International Convention against Doping in Sport.
The aims of the Council of Europe Anti-Doping Convention, the US Anti-Doping Agency and National Anti
Doping Agency (India) are also closely aligned with those of WADA.
National Anti Doping Agency
National Anti Doping Agency (NADA) was set up as registered society under the Societies Registration Act of
1860 in 2005.
It was set up with a mandate for Dope free sports in India.
The primary objectives are