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Physiological Mechanism of Sleep

The document discusses several chemical and neurological mechanisms involved in the sleep-wake cycle. It describes how substances like acetylcholine, norepinephrine, serotonin, histamine, and orexin accumulate or are released in different regions of the brain during waking and sleep states to regulate arousal and sleep.

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kakuko068
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43 views5 pages

Physiological Mechanism of Sleep

The document discusses several chemical and neurological mechanisms involved in the sleep-wake cycle. It describes how substances like acetylcholine, norepinephrine, serotonin, histamine, and orexin accumulate or are released in different regions of the brain during waking and sleep states to regulate arousal and sleep.

Uploaded by

kakuko068
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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PHYSID LOG)CAL MECHA NISM ot SlEGP

wae ep,

that aa peson tans dwsing dya


ma oleduted frbm he amount
oleep
Phy
thoit aun
mec
Drg am neel amd kecps
ack sleep oetot ,w. mus
hous of wakfuln Baaicaly
Body produes heap premotn g
ubstance that accunulates cuslng

y he Lerqe domeone t awaee;

lenges hey hae to eep to


llactiale thw dwbstanee.
- Acwmlalionm aolenostne
l nhibi tany neuroi ansmittery
relead toy dstrocylsand itproduce
drewsins and Meep.
Astnocytes
keeps socks a mM ents n the form
linér ammiscles
meeased brain aetivity causnd
this gbeo yeogn to tún lnlo
emergy. Prolongd wakefulmes leads
to devuse n glyogen.
glyogen Cases lhase

mhabitay efed on neral aetivity


This, coleeti on sewes as Heep premolhg

nest Duing
and aátrocytis
ouo waue sleapy nehe
rene theis stock

Aetylcholine i- ne the maut


ímp. newrotami mitte in veued
arwal

Two oup f acatychalnegi


neubesi One
secendn Basal forebain
thesepoduee activati en
contial wynchony
ymchony
stimlaeel
when they
Reseanches thoo that aetylcholn
agonút arsal
ieras
and
cotical
decrease them
ACh anagemist [Vamder wot l912
- Massw lk colleaes (1995) . wed
h e a ethe
mi crodi aly
release Ach in Hippo conpd
Neo cotx aclvely related to' amim al
alertnes Aud they found ACh level in
tis negien wee high bth dung
wakung nd REM teep.

I. NORE PINEPHRINE:

- Locus coesuleus L) meams Bluo


spot? n latn) main ight
fos the productin nvepinephrine ana
locatel
Ao nns LcN [nesa rlnesgc
Acirity
inchease am ani mals vigilae
attemtin to
Pay
stidi
IE SERO ToNIN

found n. haphe nueli, h i ahe


koatid tn me ullary amd potine
rqions reticula formaten.

simlatien ot naphe nuel cases


Cotical a u s a l .
loco otion
" PC PA 9 a dhug- prveno ayntheo
ot serotenin reduceo c c a l aHsal.

HIS TA MINE

- A compound aynthsi sed sy


histidine ) an Oino acid.

Anihistcomines couse dhosines by


blo clein. histamine H recep teu o
the braih.
These hitam inerge neuons
fond n Tuber mnam ielary nelus
(TMN) ot the hypothal amw.
Alivity of Hiotamie is High
duin g wakin g out Low ding.
slow waue aeep amd KEM Meep:

Z) ORE XIN;
a peptide meusotransmittes invslued
un neal contro of arsal.

[Alo colled s hypo retn , fon


hypo th alamus)
ocated amd pro duced Lateral
Hypothalamus
Oreunhas
exeitaloy
P Degeneralion of ore fne 4fed.
o a cause od Na
mesoms
Nactolepy

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