07/11/23, 18:58 Protectant and Systemic Fungicides

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Agronomic Spotlight

Protectant and Systemic

Fungicides

Click here to download a PDF version of this spotlight FUNGICIDE CLASSIFICATIONS

» Protectant fungicides prevent new infections from occurring, are usually non-systemic, have multisite modes of action, and are
CONTACT AND SYSTEMIC
active on a broader range of fungal pathogens.
» Systemic fungicides provide some control in the early post-infection period, can move to protect unsprayed plant tissues, often
have single-site modes of action, and may have narrower spectra of activity. PROTECTANTS AND CURATIVE

FUNGICIDE CLASSIFICATIONS SOURCES

Fungicides are classified based on whether or not they move through the plant after application, what groups of pathogens they ADDITIONAL INFORMATION

control, if they have any curative activity, and by what mode of action they inhibit the pathogen, indicated by their FRAC group.
Fungicide FRAC groups have been established by the Fungicide Resistance Action Committee to group fungicides by their modes
of action and their risk for cross-resistance. 1

It is common to see protectant fungicides compared to systemic fungicides. While these terms technically belong to different
classification systems, the terms are useful for describing two types of fungicides with common characteristics.

CONTACT AND SYSTEMIC

Contact and systemic are terms used to indicate where on or in the plant fungicides are active. 2 Contact (non-systemic)
fungicides remain on the plant surface (Figure 1A). They do not penetrate into plant tissues. As a result, they are only effective
before the pathogens infect the plant. 2 Because they are not absorbed into the plant, contact fungicides are susceptible to being
washed off of plant surfaces by rain or overhead irrigation. The rainfastness of a product will depend on its chemical
characteristics and the addition of any adjuvants such as spreader-stickers. However, a commonly used guideline is that one inch
of rain will remove approximately 50% of fungicide residue, and two inches of rain will remove most of the residue of a contact
fungicide from a plant surface. 3 Contact fungicides are also susceptible to degradation from other environmental factors, such as
UV light, heat, and microbial activity. Plant tissues that grow after a contact fungicide is applied will not be protected. 3 Most
protectant fungicides are contact fungicides. Systemic fungicides are absorbed into the plant to some degree (Figure
1B). 2

However, most fungicides are not truly systemic in that they are not translocated throughout the plant. There are different degrees
of systemic movement. Some products are locally systemic, meaning that they are absorbed into the plant and move only a short
distance from the point of application. 2 When a fungicide is able to spread from one side of a leaf (the upper leaf surface) to
protect the other side of the leaf (the lower leaf surface) it has translaminar movement (Figure 1B). Xylem systemic fungicides
are able to move within the leaf, usually toward the leaf tip, or move upward in the plant toward the shoot tips. They do not move
downward in the plant toward the roots. Highly systemic fungicides are able to move throughout the plant from their point of
application, both upward toward the shoot tips and downward toward the roots. Only a few fungicides are classified as highly
systemic. 2,3

Systemic fungicides are less susceptible to being washed off the plant because they are absorbed into the plant tissue. However,
some dilution of the fungicide occurs as it is redistributed within the plant and as the plant grows. Many systemic fungicides are
curative, providing some post-infection activity against the fungal pathogen. 2,3

PROTECTANTS AND CURATIVE

Protectant (preventative) fungicides act as a protective barrier for the plant, killing or inhibiting fungal spores and hyphae before
infection occurs. Protectant fungicides are only effective if applied before infection because they do not have any postinfection
effect on the pathogen within the plant. 2,3

Most protectant fungicides are also contact fungicides and broad-spectrum fungicides. Broad-spectrum fungicides work against
a wide range of fungal pathogens, often because they have multisite modes of action. The active ingredient acts on several
metabolic sites of the fungus. Multisite fungicides are in FRAC groups M-01 through M-12. For example, copperbased fungicides
are in FRAC group M-01.1 The copper molecules in the fungicide denature proteins in cells, and they act against many kinds of
proteins. Copper fungicides do not affect proteins in the plant because the fungicide remains on the plant surface. Sulfur-based
fungicides are in FRAC group M-02. These fungicides disrupt the electron transport system in the mitochondria of the cell. In
other words, they disrupt the cell’s ability to use energy. Sulfur fungicides often help manage fungal diseases by inhibiting spore
germination.4 Other broadspectrum, protectant fungicides include mancozeb (FRAC group M-03), captan (FRAC group M-04),
and chlorothalonil (FRAC group M-05). Multisite, protectant fungicides are often mixed with systemic fungicides to help reduce
the risk of developing fungicide resistant strains of fungal pathogens. 2,4,5

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07/11/23, 18:58 Protectant and Systemic Fungicides
Fungicides that are able to stop established infections and minimize further symptom development have “curative” activity. These
fungicides can kill spores and fungal hyphae after the pathogen has penetrated the plant. This effect is also referred to as
kickback or eradicant activity. Curative activity is usually limited to the early infection period of the disease, often within 24 to 72
hours of initial infection, depending on the fungicide and the rate of application. 2,3 Curative fungicides are systemic fungicides by
nature. The fungicides are absorbed into the plant, where they kill or inhibit the fungus and stop the infection process. Some
systemic fungicides have both preventative and curative activity. 2

Many curative fungicides have single-site modes of action, meaning that they act against single points of function in a metabolic
pathway of a fungus. The chemical/biological bases for the modes of action are numerous and result in damage to cell
membranes, inactivation of enzymes, disruption of energy production/respiration, inhibition of nucleic acid synthesis, and
disruption of growth and development. 2 Fungicides that have similar modes of action and belong to the same FRAC group may
or may not have similar chemical structures.

Many curative fungicides have narrower spectra of activity (effective against a smaller range of pathogens), as compared to
protectant fungicides. For example, phenylamide fungicides, such as metalaxyl, are used almost exclusively to manage oomycete
organisms, including Pythium and Phytophthora. Single-site fungicides may be at higher risk for enhancing the development of
fungicide resistance in pathogens. Resistance management programs are often recommended to prolong the effectiveness of
these types of fungicides. 2

Some curative fungicides also have antisporulant activity, meaning that they inhibit the ability of the fungus to produce spores.
The fungal pathogen may be able to continue to grow in the plant tissue and cause symptoms. However, the fungus is not able to
produce spores, which limits the ability of the pathogen to spread to other plants or other locations on the same plant. 1

SOURCES
1 FRAC Code List ©*2021: Fungal control agents sorted by cross resistance pattern and mode of action.
https://www.frac.info/knowledge-database/knowledge-database.
2 McGrath, M. 2016. What are fungicides? The Plant Health Instructor. DOI: 10.1094/PHI-I-2004-0825-01.
https://www.apsnet.org/edcenter/disimpactmngmnt/topc/Pages/Fungicides.aspx.
3 Schilder, A. 2010. Fungicide properties and weather conditions. Michigan State University.
https://www.canr.msu.edu/news/fungicide_properties_and_weather_
conditions#:~:text=Since%20systemic%20fungicides%20are%20absorbed,the%20
outside%20of%20the%20plant.&text=Also%2C%20fungicides%20and%20formulations%20differ,to%20adhere%20to%20plant%20surfaces.
4 Wyenandt, A. 2021. Understanding protectant fungicides (FRAC groups M01-M11). Plant & Pest Advisory, Rutgers Cooperative
Extension. March 10, 2021.
5 Phillips, B. and Hausbeck, M. 2019. Broad-spectrum fungicides for vegetables. Michigan State University, MSU Extension.
https://www.canr.msu.edu/news/broad_spectrum_fungicides_for_vegetables.
6 Phillips, B., Maynard, E., Egel, D., Ingwell, L., and Meyers, S. 2019. Midwest vegetable production guide for commercial
growers 2021.
Websites verified 5/6/2021

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07/11/23, 18:58 Protectant and Systemic Fungicides
ADDITIONAL INFORMATION
For additional agronomic information, please contact your local seed
representative.
Performance may vary from location to location and from year to year, as local growing, soil and weather conditions
may vary. Growers should evaluate data from multiple locations and years whenever possible and should consider
the impacts of these conditions on the grower’s fields. The recommendations in this article are based upon
information obtained from the cited sources and should be used as a quick reference for information about vegetable
production. The content of this article should not be substituted for the professional opinion of a producer, grower,
agronomist, pathologist and similar professional dealing with vegetable crops.
BAYER GROUP DOES NOT WARRANT THE ACCURACY OF ANY INFORMATION OR TECHNICAL ADVICE PROVIDED
HEREIN AND DISCLAIMS ALL LIABILITY FOR ANY CLAIM
INVOLVING SUCH INFORMATION OR ADVICE.
9050_SE_S12 Published 06/10/2021
ALWAYS READ AND FOLLOW PESTICIDE LABEL DIRECTIONS. Bayer, Bayer Cross Design, and Seminis® are
registered trademarks of Bayer Group. All other trademarks are property of their respective owners. © 2021 Bayer
Group. All rights reserved.

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