1 - Introduction To Pathology

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Introduction to pathology

Associate professor Dr. Ashish Lakhey


PATHOLOGY - Definition

Pathology is the study (logos) of suffering (pathos).

So, we can say that-

Pathology is the Scientific study of disease.

More specifically, pathology may be defined as the "scientific


study of the functional, molecular (biochemical), cellular, tissue,
or organ/ system in response to injurious agents or adverse
influences."
It is a discipline that bridges clinical practice
and basic science
DISEASE

Disease is defined ----

As any disturbance of the structure and/or


function of the body or any of its constituent parts outside the
normal range, especially one that produces specific clinical signs.
CHARACTERISTICS OF DISEASE
(Components of Pathology)

1.Predisposing Causes of Disease: Factors which make an


individual more susceptible to a disease (damp weather, poor
ventilation, etc.)

2. Etiology : This involves the study of pathogens that cause disease

3. Pathogenesis: The mechanism causing the disease

4. Morphology: The structural features of the disease

5. Clinical Significance: The functional features of the disease


Some important terminologies related
with morphology
Sequela: A secondary consequence or result (Most of the
times synonymous with complication)
NOMENCLATURE OF DISEASE

1. Primary and secondary


They may be used to describe the causation of a disease.

Primary Means that the disease is without evident cause. Example,


primary hypertension is defined as abnormally high BP without
apparent cause.

Secondary Means that the disease represents a complication of


some underlying lesion. Example, secondary hypertension is
defined as abnormally high BP as a consequence of some other
lesion (e.g. renal artery stenosis).
NOMENCLATURE OF DISEASE

2. Acute and chronic

Acute conditions have a rapid onset, often but not always followed
by a rapid resolution.

Chronic conditions may follow an acute initial episode, but often


are of deceptive onset, and have a prolonged course lasting months or
years.

Subacute, a term not often used now, is intermediate between acute


and chronic.
What does a pathologist (Doctors of The Doctors) do?

To render diagnoses and guide therapy,


pathologists
- Identify changes in the gross or
microscopic appearance (morphology)
of cells and tissues,
and, biochemical
alterations in body fluids (such as blood
and urine).

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