Bmepg 2022
Bmepg 2022
Bmepg 2022
November 2022
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
REGULATIONS 2022
CHOICE BASED CREDIT SYSTEM
M.E.BIOMEDICAL ENGINEERING
2. To enable the graduates to acquire technical knowledge and skills required for
Biomedical Engineering that meets industrial and hospital requirements.
4. To facilitate the graduates to exhibit leadership skills, make decisions with societal and
ethical responsibilities, function and communicate effectively in multidisciplinary
settings.
5. To enable the graduates to recognize the need for lifelong learning, enhance their
technical competencies throughout their career and become successful Entrepreneurs.
SEMESTER-I
S. COURSE CATE- PERIODS PER TOTAL
NO. CODE COURSE TITLE GORY WEEK CONTACT CREDITS
L T P PERIODS
THEORY
1. MA1115 Algebra, Optimization and Fourier FC 3 1 0 4 4
Transform
2. RM1122 Research Methodology and IPR RMC 3 0 0 3 3
3. BM1113 BioSignal Processing PCC 3 0 0 3 3
4. BM1114 Human Anatomy and Physiology PCC 3 0 0 3 3
5. BM1115 Applied Medical Image Processing PCC 3 0 2 5 4
6. BM1116 Bio Medical Sensors & PCC 3 0 0 3 3
Instrumentation
7. Audit Course–I* AC 2 0 0 2 0
PRACTICALS
8. BM1181 Clinical Instrumentation and Design PCC 0 0 3 3 1.5
Laboratory
9. BM1182 BioSignal Processing Laboratory PCC 0 0 3 3 1.5
TOTAL 20 1 8 29 23
*Audit course is optional
SEMESTER II
S. COURSE CATE- PERIODS TOTAL
NO. CODE COURSE TITLE GORY PER WEEK CONTACT CREDITS
L T P PERIODS
THEORY
1. BM1211 Medical Device Design PCC 3 0 0 3 3
2. BM1212 Biomaterials and Biomechanics PCC 3 0 0 3 3
3. BM1213 Medical Imaging Systems PCC 3 0 0 3 3
4. BM1214 AI and Machine Learning PCC 3 0 2 5 4
5. Professional Elective I PEC 3 0 0 3 3
6. Professional Elective II PEC 3 0 0 3 3
7. Audit Course–II* AC 2 0 0 2 0
PRACTICALS
8. BM1281 Medical Device Design Laboratory PCC 0 0 4 4 2
9. BM1282 Term Paper Writing and Seminar EEC 0 0 2 2 1
TOTAL 20 0 8 28 22
*Audit course is optional
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SEMESTER III
PERIODS TOTAL
S. COURSE COURSE TITLE CATE- PER WEEK CONTACT CREDITS
NO. CODE GORY L T P PERIODS
THEORY
1. Professional Elective III PEC 3 0 0 3 3
2. Professional Elective IV PEC 3 0 2 5 4
3. Open Elective OEC 3 0 0 3 3
PRACTICALS
4. BM1381 Hospital / Biomedical Industry EEC 0 0 4 4 2
Training
5. BM1391 Project Work I EEC 0 0 12 12 6
TOTAL 9 0 18 27 18
SEMESTER IV
PERIODS TOTAL
S. COURSE COURSE TITLE CATE- PER WEEK CONTACT CREDITS
NO. CODE GORY L T P PERIODS
PRACTICALS
1. BM1491 Project Work II EEC 0 0 24 24 12
TOTAL 0 0 24 24 12
TOTAL NO. OF CREDITS: 75
PROFESSIONAL ELECTIVES
SEMESTER II, PROFESSIONAL ELECTIVES – I
S. COURSE CATE- PERIODS TOTAL
NO. CODE COURSE TITLE GORY PER WEEK CONTACT CREDITS
L T P PERIODS
1. BM1231 Diagnostic and Therapeutic PEC 3 0 0 3 3
Equipments
2. BM1232 Rehabilitation Engineering PEC 3 0 0 3 3
3. BM1233 Medical Optics PEC 3 0 0 3 3
4. BM1234 Human Assist Devices PEC 3 0 0 3 3
5. BM1235 Medical Device Standards and PEC 3 0 0 3 3
Regulation
6. BM1236 Nuclear Medicine PEC 3 0 0 3 3
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
SUMMARY
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Random variables – Probability function – Moments – Moment generating functions and their
properties – Binomial, Poisson, Geometric, Uniform, Exponential, Gamma and Normal
distributions – Function of a Random Variable.
Formulation – Graphical solution – Simplex method – Two phase method – Transportation and
Assignment models.
TOTAL: 60 PERIODS
REFERENCES:
1. Andrews, L. C. and Philips. R.L., “Mathematical Techniques for engineering and scientists”,
Prentice Hall of India, New Delhi,2006.
2. Bronson, R.,” Matrix Operation”, Schaum’s outline series, Tata McGrawHill, New York,2011.
3. O’Neil P.V., “Advanced Engineering Mathematics”, Cengage Learning”, 8 th Edition, India,
2017.
4. Oliver C. Ibe, “Fundamentals of Applied Probability and Random Processes”, Academic Press,
Boston, 2014.
5. Sankara Rao,K., “ Introduction to partial differential equations” Prentice Hall of India Pvt. Ltd.,
3rd Edition, New Delhi,2010.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
6. Taha H.A., “Operations Research: An Introduction”, Ninth Edition, Pearson Education, Asia,
10th Edition, New Delhi, 2017.
COURSE OUTCOMES:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 3 2 2 3 - 1
2 3 2 2 3 - 1
3 3 2 2 3 - 1
4 3 2 2 3 - 1
5 3 2 2 3 - 1
Low (1); Medium (2); High (3)
Research Plan: Need – Features – Framework - Components – Activity-Time (Gantt) Chart - Data
Collection: Data types - Sampling - Measurement Scales – Data Collection Methods - Selection
of Appropriate Method for Data Collection.
Research Techniques and Tools: Basics of Statistics (Mean, Mode, Median; Coefficient of
Variation, Standard deviation; Correlation, Least squares fitting methods) – ANOVA-Multivariate
analysis - Testing of Hypothesis - Overview of software packages for data analysis (Example:
SPSS, R-Programming)
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UNIT V PATENTS 9
Introduction to Patent Law – Indian Patent Law: An Overview - Concept of Patent - Product /
Process Patents & Terminology - Procedure for Filing of Patent Application and Types of
Applications.
TOTAL: 45 PERIODS
REFERENCES:
1. C.R.Kothari and Gaurav Garg, “Research Methodology: Methods and Techniques” New
Age International Publications, 3rd Edition 2014 (UNIT I to UNIT III).
2. Ranjit Kumar, “Research Methodology a step-by-step guide for beginners”, SAGE
publications Ltd 3rd Edition 2011.
3. Stuart Melville and Wayne Goddard, “Research Methodology: An Introduction for
Science & Engineering students”, Juta and Co., Limited, 1st Edition, 1996.
4. William M. Trochim, “Research Methods Knowledge Base”, Atomic Dog publishing, 1st
Edition, 2005.
5. Prasad Karhad, “How to Patent and Idea in India”, 2018.
6. Dr. KanthaBabu, “Textbook on Intellectual Property Rights”, Centre for Intellectual
Property Rights, Anna University, Chennai, 2nd Edition, 2020.
7. Professional Programme Intellectual Property Rights, Law and practice, The Institute of
Company Secretaries of India, Statutory body under an Act of parliament, September
2013 (UNIT IV & UNIT V).
COURSE OUTCOMES:
On completion of the course the student would be able to:
CO1: Demonstrate the components and process of research.
CO2: Select methods for data collection, processing, analysis and formulate Research Problems
with unambiguous objective(s) and assumptions, and mark out the scope the research.
CO3: Develop / Design a research plan with procedure and prepare a research paper/ well-
structured thesis.
CO4: Illustrate various IPR procedures, laws and process of patent filing.
CO5: Do patent search and file copy rights, trademarks and patents.
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 1 - - - -
2 1 - - 3 - -
3 1 - 2 1 - 1
4 1 - 1 1 2 2
5 1 - 1 1 - 2
Low (1); Medium (2); High (3)
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Time series analysis – linear predictive models, process order estimation, Segmentation - fixed
segmentation and adaptive segmentation, Application in EEG, PCG and HRV signals. Estimation
of mean of finite time signals. Spectrum – Power Spectral Density function, Cross-Spectral
Density, Coherence function, Cepstrum and Homomorphic filtering, Blackman Turkey method,
Application in Heart rate variability, PCG signals.
Filtering – LMS adaptive filter, RLS adaptive filter, adaptive noise cancelling in ECG, improved
adaptive filtering in FECG, Muscle contraction interference. Wavelet detection in ECG –
structural features, matched filtering, adaptive wavelet detection, detection of overlapping
wavelets.
Removal of artifact – ECG, Event detection –ECG, P Wave, QRS complex, T wave, Correlation
analysis of EEG signals, Average of Signals-PCG and ECG.
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5. Willis J.Tompkins, Biomedical Digital Signal Processing, Prentice Hall of India, New Delhi,
2006.
COURSE OUTCOMES:
At the end of the course students will be able to
CO1: Analyse the different types of signals & systems.
CO2: Analyse signals in time series domain & estimate the spectrum.
CO3: Understand the significance of wavelet detection applied in bio signal processing.
CO4: Extract the features from bio signal.
CO5: Describe the performance of the classification of bio signals.
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 1 2 3 3 2
2 2 1 1 3 2 2
3 2 1 2 3 3 2
4 2 1 2 2 2 2
5 3 1 3 3 3 2
Low (1); Medium (2); High (3)
Organization of the human body: from atoms to the entire organism. Anatomical directions and
planes. Cell structures and functions – Plasma membrane and sub-organelles. Cell membrane
transport. Cell to cell signaling, Cell cycle and regulations. Action potential, Homeostasis, Types
of specialized tissues.
Skeletal: Types of Bone and function – Physiology of Bone formation – Division of Skeleton –
Types of joints and function – Types of cartilage and function. Muscular: Parts of Muscle –
Movements. Respiratory: Parts of Respiratory Systems – Types of respiration - Mechanisms of
Breathing – Regulation of Respiration.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Nervous: Structure, types and properties of Neuron, Mechanism of Nerve impulse. Brain:
Structure and parts of brain – central and peripheral nervous system – Reflex mechanism.
Sense: Structure and functions of eye and ear. Reproductive: Anatomy of testis and ovary.
Digestive: Organs of Digestive system – Digestion and Absorption. Urinary: Structure of Kidney
and Nephron – Mechanisms of Urine formation – Regulation of Blood pressure by Urinary
System – Urinary reflex.
TOTAL: 45 PERIODS
REFERENCES:
1. Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew, Fundamentals of Anatomy and
Physiology. 11th Edition, Pearson Publishers, 2014.
2. Gillian Pocock, Christopher D. Richards, The human Body – An introduction for Biomedical
and Health Sciences, Fifth Edition , Oxford University Press, USA, 2017.
3. William F.Ganong, “Review of Medical Physiology”, 22nd Edition, Mc Graw Hill, New Delhi,
2010.
4. Eldra Pearl Solomon, “Introduction to Human Anatomy and Physiology”, - 4thEdition , W.B.
Saunders Company, 2015.
5. Guyton & Hall, “Medical Physiology”, 13th Edition - Elsevier Saunders, 2015. Elaine.N.Marieb,
"Essential of Human Anatomy and Physiology", Eleventh Edition, Pearson Education, New
Delhi,2015.
COURSE OUTCOMES:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 3 2 2 2 2 2
2 2 2 2 2 2 2
3 2 2 2 1 1 2
4 2 2 2 - 1 1
5 2 1 1 1 1 1
Low (1); Medium (2); High (3)
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
L T P C
BM1115 APPLIED MEDICAL IMAGE PROCESSING 3 0 2 4
COURSE OBJECTIVES:
The main learning objective of this course is to prepare the students for:
To understand the fundamentals of medical image processing techniques.
To understand the basic concepts of image enhancement, image restoration, morphological
image processing, image segmentation, feature recognition in medical images.
To provide information about various medical imaging modalities.
To provide information about classification and image visualization in medical image
processing projects
To familiarize the student with the image processing facilities in Matlab, Python and
openCV.
Image perception, MTF of the visual system, Image fidelity criteria, Image model, Image
sampling and quantization – two dimensional sampling theory, Image quantization, Optimum
mean square quantizer, Image transforms – 2D-DFT and other transforms. DFT, DCT, KLT, SVD.
Pixels and voxels – algebraic image operations - gray scale and color representation- depth-
color and look up tables - image file formats- DICOM- other formats- Analyze 7.5, NifTI and
Interfile, Image quality and the signal to noise ratio
Image segmentation- pixel based, edge based, region based segmentation. Image
representation and analysis, Feature extraction and representation, Statistical, Shape, Texture,
feature and image classification – Statistical, Rule based, Neural Network approaches
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
PRACTICAL EXERCISES:
The following experiments should be performed in OpenCV / Python / Scilab / Matlab Octave /
other Open source software.
LIST OF EXPERIMENTS
COURSE OUTCOMES
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 - 2 2 2 1
2 2 1 2 3 2 1
3 1 1 2 2 1 1
4 3 - 2 3 3 2
5 2 1 1 2 1 2
Low (1); Medium (2); High (3)
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Basics of Critical Care Equipment – Bedside monitors, ICU / CCU equipment – Defibrillator and
its types, Pacemaker and its types. Ventilator and its types, Dialysers, Endoscopy, laparoscopy,
Oxygenators.
TOTAL: 60 PERIODS
REFERENCE:
1. Geddes LA and Baker L.E Principals of Applied Biomedical Instrumentation, 3rd Edition, John
Wiley and sons, New york 1989.
2. Joseph J Carr and John Brown Introduction to Biomedical equipment Technology- Pearson
Education 4th edition New Delhi 2001.
3. Khandpur R.S Hand Book of Biomedical Instrumentation – Tata Mc Graw Hill publication ,
New Delhi 3rd edition 2014.
4. Webster J.G Medical Instrumentation application and design – John Wiley and sons New
York 4thedition 2009
5. Leslie Cromwell, Biomedical Instrumentation and measurement, Prentice Hall of India, New
Delhi, 2nd edition, 2015
6. Richard Aston, Principles of Biomedical Instrumentation and Measurement, Merril Publishing
Company, 2002
COURSE OUTCOMES:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 2 1 2 1 1
2 2 2 2 2 - 1
3 2 1 1 - - 1
4 2 2 2 3 3 2
5 2 3 2 2 2 2
Low (1); Medium (2); High (3)
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
LIST OF EXPERIMENTS:
COURSE OUTCOMES:
On completion of the course, students will be able to:
CO1: Design a preamplifier on his own
CO2: Design amplifier and Isolation circuits for any bio signals.
CO3: Obtain the domain knowledge in Basic medical equipment.
CO4: Obtain the domain knowledge in critical care equipment.
CO5: Get familiarized with important of 3D printing in medical field
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 2 3 3 3 3
2 2 2 3 3 3 3
3 2 2 3 3 3 3
4 2 2 3 3 3 3
5 2 2 3 3 3 3
Low (1); Medium (2); High (3)
COURSE OUTCOMES:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 3 2 3 3 1 2
2 3 2 3 3 1 2
3 3 2 3 3 1 2
4 3 2 3 3 1 2
Low (1); Medium (2); High (3)
Needs finding, problem identification, prior art searches, strategy and concept generation,
estimation, sketching, sketch modelling, machine elements, ergonomics and prototyping.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Hardware design, Hardware risk analysis, Design and project merits, Design for six sigma,
software design, software coding, software risk analysis, software metrics, licensing and
alternate pathways.
Transfer to and deliverables. Standard-ISO, IES, Intellectual Property - Patents, Copy rights,
Trademarks, Trade secrets. manufacturing, documents.
TOTAL: 45 PERIODS
REFERENCE:
1. Matthew Bret Weinger, Michael E. Wiklund, Daryle Jean Gardner-Bonneau’Handbook of
Human Factors in Medical Device Design’,CRC press,2010.
2. Peter J. Ogrodnik, “Medical Device Design: Innovation from Concept to Market” Academic
Press Inc; 1st Edition, 2012.
3. Paul H. King, Richard C. Fries, Arthur T. Johnson, “Design of Biomedical Devices and Systems”,
Third Edition, 2014.
4. Stefanos Zenios , Josh Makower , Paul Yock , Todd J. Brinton , UdayN. Kumar , Lyn Denend,
Thomas M. Krummel, “Biodesign: The Process of Innovating Medical Technologies”,
Cambridge University Press; 1 edition, 2009.
COURSE OUTCOMES:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 - 2 2 2 2 -
2 3 - - 2 - 1
3 1 - 2 3 - 2
4 3 2 2 2 - 2
5 3 1 2 2 2 2
Low (1); Medium (2); High (3)
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Definition of stress, strain, elasticity, viscosity, kinetics and kinematics. Newton’s law of motion,
viscoelasticity, constitutive equation for Newtonian fluid, Non- Newtonian fluid and Hookean
elastic solid.
Hard Tissues: Structure, composition & mechanical properties of bone, cortical and cancellous
bones, viscoelastic properties, Maxwell & Voight models – anisotropy. Electrical properties of
bone, type of fractures, biomechanics of fracture healing.
Soft Tissues: Structure and functions of Soft Tissues: Cartilage, Tendon, Ligament, and Muscle-
Material Properties and Modeling.
General concepts of Implants, classification of implants, Soft tissue replacements and Hard
tissue replacements, Design of Joint replacement – Hip and Knee joint replacement.
Gait analysis, body & limbs: mass & motion characteristics actions, forces transmitted by joints-
normal & disable human body, normal & fast gait on the level. Patterns: Push/Throw
Continuum Biomechanics of push - like motions, Biomechanics of throw - like motions.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
SUGGESTED ACTIVITIES:
1: Stress-strain analysis of hip prosthesis
2: Estimation of hemocompatibility of biomaterials by hemolysis studies
3: Measurement of torque required to tap and screwing in jaw bone.
4: Determination of moment of inertia of human limb using dynamometer.
TOTAL: 45 PERIODS
REFERENCES:
1. Jonathan Black, Biological Performance of Materials- Fundamentals of bio compatibility, 4th
Edition, CRC Press 2005.
2. Larry L. Hench and Julian R. Jones, Biomaterials, Artificial organs, and Tissue Engineering,
2005.
3. Y. C. Fung, Biomechanics: Mechanical properties in living tissues, Springer Verlag, New York
1981.
4. Susan J. Hall, Basics Bio Mechanics 4th Edition, McGraw-Hill Publishing Co, 2002.
5. Subrata pal, Text book of Biomechanics, Viva education private limited, 2009.
6. C. R Ethier and C. A. Simmons, Biomechanics from cells to organisms, Cambridge University
Press, 2007.
7. D. Dawson and Right, Introduction to Bio-mechanics of joints and joint replacement.
8. Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons, Biomaterial Science;
An Introduction to Materials in Medicine, 2nd Edition, Elsevier Academic Press, San Diego,
2004.
COURSE OUTCOMES
To understand the production of x-rays and its application to different medical Imaging.
To explore the different types of Radio diagnostic techniques.
To understand the special imaging techniques for visualizing the cross sections of the body.
To understand the production of Magnetic resonance images for various pulse sequences.
To realize the importance of image quality assessments for medical imaging systems.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
UNIT I X – RAYS 9
Principle and production of soft X – Rays, X- ray machine and digital radiography, principles of
Angiography and Fluoroscopic Techniques, digital subtraction angiography, mammography.
Need for sectional images, Principles of sectional scanning, Method of convolution and Back
Propagation, Methods of reconstruction, Multislice CT, artifacts.
Principle of MRI, MRI instrumentation, Imaging Different Sections of the Body, Tissue
Characterization, MR Spectroscopy, Functional MRI. Alpha, Beta, Gamma Emission, different
types of Radiation Detectors, Functions of Gamma Camera, PET, SPECT, PET/CT, PET/MRI.
COURSE OUTCOMES:
Up on completion of the course, students will be able to
CO1:Explain the functionalities and applications of X ray in medicine.
CO2:Demonstrate the images acquisition procedures using CT.
CO3:Explain the suitable projection methods for anatomy and biology specific.
CO4:Demonstrate the applications of magnetic field in the field of medicine.
CO5:Explain the assessment method to quantify the presence of noise in the image.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
CO Pos
PO1 PO2 PO3 PO4 PO5 PO6
1 1 2 1 2 1 2
2 2 2 1 2 2 1
3 2 2 2 2 1 1
4 2 2 1 2 2 1
5 2 2 2 2 2 2
Low (1); Medium (2); High (3)
COURSE OBJECTIVES:
Biological Neurons and their Artificial models, Learning Rules, Single Layer Perceptron
Classifiers Back Propagation Network, generalized delta rule, Associative Memory, Adaptive
Resonance Theory (ART) Network Descriptions.
Fuzzy Logic System: Basic of fuzzy logic theory , crisp and fuzzy sets, Basic set operation like
union , interaction , complement , T-norm , T-conorm , fuzzy relations, fuzzy if-then rules , fuzzy
reasoning, Neuro-Fuzzy Modeling: Adaptive Neuro-Fuzzy Inference System (ANFIS) , ANFIS
architecture , Hybrid Learning Algorithm.
Support Vector Machines, RBF Network. Introduction to Deep Learning – Convolutional Neural
Network. Case Study – Neural Network based Classification of Biosignal and Medical Images.
TOTAL: 45 PERIODS
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
PRACTICAL EXERCISES:
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
LIST OF EXPERIMENTS:
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
2. Stating an objective
5. Studying the papers and understanding the authors contributions and critically analysing
Please keep a file where the work carried out by you is maintained.
Selection of area of You are requested to select 2nd week 3 % Based on clarity of
interest and Topic an area of interest, topic thought, current
Stating an Objective and state an objective relevance and clarity in
writing
Collecting Information 1. List 1 Special Interest 3rd week 3% ( the selected
about your area & Groups or professional information must be
topic society area specific and of
2. List 2 journals international and
3. List2 conferences, national standard)
symposia or workshops
4. List 1 thesis title
5. List 3 web presences
(mailing lists, forums, news
sites)
6. List 3 authors who
publish regularly in your
area
7. Attach a call for papers
(CFP) from your area.
Collection of Journal 1. You have to provide a 4th week 6% (the list of standard
papers in the topic in complete list of papers and reason for
the context of the references you will be selection)
objective – collect 20 & using- Based on your
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Final Draft Complete the final draft of 13th week 10% (formatting,
your paper English, Clarity and
linking) 4% Plagiarism
Check Report
Seminar A brief 15 slides on your 14th & 15th week 10%(based on
paper presentation and Viva-
voce)
TOTAL: 30 PERIODS
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 2 1 2 2 1
2 2 2 2 1 2 1
3 2 2 2 1 1 1
4 2 2 1 1 2 2
5 2 2 2 2 2 2
Low (1); Medium (2); High (3)
Pace makers - different types, batteries for pace makers, Design Concept. DC defibrillators,
asynchronous and synchronous types, patient monitoring system, principles of bio telemetry
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
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COURSE OUTCOMES
After the completion of the course the student will be able to
CO1. Explain the fundamentals of rehabilitation and rehabilitation team members.
CO2. Descirbe the key engineering principles of rehabilitation and assistive technology.
CO3. Apply the types of therapeutic exercises to benefit the society.
CO4. Design and apply different types Hearing aids, visual aids and their application in
biomedical field and hence the benefit of the society.
CO5. Explain engineering concepts in Virtual reality based rehabilitation devices.Identify
prosthetic and orthotic devices for restoration of limb function
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 2 1 - 1 1
2 2 2 1 - - 2
3 1 2 1 - - 2
4 2 3 2 3 3 2
5 1 3 2 2 2 2
Low (1); Medium (2); High (3)
Optical properties of tissue- melanin, bilirubin, tissue and their spectrum, optical characteristics
of constituents of blood – RBC, hemoglobin properties, plasma, oxygenated and deoxygenated
hemoglobin, Laser tissue Interaction-Chemical, Thermal, Electromechanical. Photo ablative
processes. Laser safety procedures.
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Phototherapy, Photodynamic therapy (PDT) - Principle and mechanism - Oncological and non-
oncological applications of PDT - Biostimulation effect – applications. Laser in tissue welding,
lasers in dermatology, lasers in ophthalmology, otolaryngology, urology, neurology,
orthopedics, gastroenterology.
Light transport in the optical fiber - Total internal reflection, Numerical aperture, Angle of
acceptance. losses in fiber, Optical sensors based on polarization, magnetic sensors, Medical
applications of fiber optic sensors in measuring temperature, pressure, flow and chemical
activities, types of optical scopes.
TOTAL: 45 PERIODS
REFERENCES:
1. Mark E. Brezinski, “Optical Coherence Tomography: Principles andApplications”,Academic
Press, 2006.
2. MarkolfH.Niemz, “Laser-Tissue Interaction Fundamentals and Applications”, Springer, 2007.
3. Paras N. Prasad, “Introduction to Biophotonics, A. John Wiley and sons, Inc.
Publications,2003.
4. R. Splinter and B.A. Hooper, “An Introduction to BioMedical Optics”, Taylor and Francis,2007.
5. Tuan Vo Dinh, “Biomedical photonics – Handbook”, CRC Press LLC, 2003.
COURSE OUTCOMES
After the completion of the course the student will be able to
CO1. Understand various optical properties of tissue.
CO2. Describe the photonics instruments.
CO3. Know the diagnostic applications of lasers in medical fields.
CO4. Explain the therapeutic and surgical applications of lasers in medical fields.
CO5. Describe the types of fiber optic sensors used in medical application.
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 1 2 1 - -
2 1 1 1 - - 1
3 2 1 2 - - 2
4 2 1 2 1 - 2
5 2 1 2 1 - 2
Low (1); Medium (2); High (3)
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Condition to be satisfied by the H/L System. Different types of Oxygenators, Pumps, Pulsatile
and Continuous Types, Monitoring Process, Shunting, The Indication for Cardiac Transplant,
Driving Mechanism, Blood Handling System, Functioning and different types of Artificial Heart,
Mock test setup for assessing its Functions.
Synchronous Counter pulsation, Assisted through Respiration Right Ventricular Bypass Pump,
Left Ventricular Bypass Pump, Open Chest and closed Chest type, Intra Aortic Balloon Pumping
Veno Arterial Pumping, Prosthetic Cardiac Valves, Principle and problem, Biomaterials for
implantable purposes, its characteristics and testing.
Spinal orthotics and Prosthesis, Splint – Static and Dynamic. Hand and Arm Replacement -
Different Types of Models Externally Powered Limb Prosthesis, Intelligent prosthesis, Lower
Limb and Upper limb orthotic devices, Functional Electrical Stimulation, Sensory Assist Devices,
Materials for Prosthetic and orthotic devices, Haptic Devices, Transcutaneous electrical nerve
stimulator.
Pulmonary disease diagnosis, Ventilator and its types-Intermittent positive pressure, Breathing
Apparatus Operating Sequence, Electronic IPPB unit with monitoring for all respiratory
parameters. Types of Deafness, Hearing Aids, Construction and Functional Characteristics.
TOTAL: 45 PERIODS
REFERENCES:
1. Andreas.F.Vonracum, Handbook of biomaterial evaluation, Mc-Millan publishers, 1980.
2. Albert M.Cook and Webster J.G., Therapeutic Medical Devices, Prentice Hall Inc.,New
Jersey,1982.
3. Gray E Wnek, Gray L Browlin – Encyclopedia of Biomaterials and Biomedical Engineering –
Marcel Dekker Inc New York 2004.
4. John. G . Webster – Bioinstrumentation - John Wiley & Sons (Asia) Pvt Ltd - 2008.
5. Kolff W.J., Artificial Organs, John Wiley and Sons, New York, 1979.
6. Gerr . M. Craddock “Assistive Technology-Shaping the future”, IOS Press, 1st edition, 2003
COURSE OUTCOMES
After the completion of the course the student will be able to
CO1. Knowledge about the importance of Heart lung machine and artificial Heart.
CO2. Knowledge about the importance of different types of assist devices and related issues.
CO3. Understand about the implantation of artificial kidney.
CO4. Explore the different types of models for Prosthetic and orthotic purpose.
CO5. Perceive the knowledge in different types of respiratory and hearing aids.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 - 1 1 3 2
2 1 - 1 1 3 1
3 1 - 1 1 3 1
4 1 - 2 1 2 3
5 1 - 2 2 1 3
Low (1); Medium (2); High (3)
BM1235 MEDICAL DEVICE STANDARDS AND REGULATION
L T P C
3 0 0 3
COURSE OBJECTIVES:
Understand standards and safety aspects of medical devices.
Understand the hospital safety standards and maintenance
Describe medical device regulations.
Describe medical device regulations
Describe medical device risk assessment and regulatory requirements
UNIT I STANDRADS AND SAFETY 9
Quality management system for medical devices (ISO 9001 and ISO13485), safety and
standardization for risk management (ISO 14971), European standard conformity (CE marking),
FDA guidelines for medical devices approval and classification based on risk assessment.
Life Safety Standards- Protecting Occupants, Protecting the Hospital From Fire, Smoke, and
Heat, Protecting Individuals From Fire and Smoke, Providing and Maintaining Fire Alarm
Systems, Systems for Extinguishing Fires Environment of Care Standards-Minimizing EC Risks,
Smoking Prohibitions, Managing Hazardous Material and Waste, Maintaining Fire Safety
Equipment, Features, Testing, Maintaining, and Inspecting Medical Equipment
General requirements for basic safety & essential performance of medical equipment, IEC
60601 standards- Base Standard-general requirement of electrical medical devices, Collateral
Standards- EMC radiation protection &programmable medical device system, Particular
Standards-type of medical device.
Medical device and in vitro diagnostics: Introduction & types of devices including combination
devices. Medical Device Rules, 2017: Implications on medical devices. Classification of medical
devices. Labelling of medical devices and in vitro diagnostics.
Inspection of medical device and IVD establishments. ISO 14971 (Medical devices: Application
of risk management to medical devices). Regulatory requirements of biocompatibility of
medical devices and ISO 10993. Clinical investigation of medical devices, regulation of
investigational medical devices. Medical device regulation: International practices.
TOTAL: 45 PERIODS
34
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
REFERENCES:
1. Seeram Ramakrishna, Lingling Tian, Charlene Wang, Susan Liao, Wee EongTeo, Medical
Devices Regulations, Standards and Practice, Wood head Publishing, 1st Edition, 2015.
2. Joint Commission International Accreditation Standards for Hospitals, Joint Commission
International, 6th Edition, 2017.
3. Joseph D. Nally (ed.), Good Manufacturing Practices for Pharmaceuticals ,CRC Press sixth
edition, 2007.
4. https://nptel.ac.in/courses/127106136.
5. MDR17, Regulation of Medical Devices.
COURSE OUTCOMES
After the completion of the course the student will be able to
CO1. Describe the key point in standard and safety of medical devices.
CO2. Introduce the students with the knowledge of hospital safety and standards.
CO3. Introduce the students with the knowledge of essential requirements in medical
equipments.
CO4. Introduce device regulation and its types.
CO5. Acquire knowledge medical device risk assessment.
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 2 1 - 1 -
2 1 2 1 - 1 -
3 1 2 1 - 1 -
4 1 2 1 - 1 -
5 1 2 1 - 1 -
Low (1); Medium (2); High (3)
Physics of Radioactivity: Radionuclide Decay Terms and Relationships – Activity – Physical half
Life – Fundamental Decay Equation, Nuclear Transformation – Alpha Decay, Beta-Minus Decay-
Beta Plus – Electron Capture – Isomeric Transition – Decay Schemes.
35
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Radionuclide detection and measurement - Type of detectors – pulsed and current mode -
spectroscopy, Gas Filled detectors, Scintillation detectors, Semiconductor detectors, Pulse
height spectroscopy, Non– imaging detector applications, Counting Statistics.
Planar Nuclear Imaging: Anger Scintillation Camera – Design and principles of operation-
performance – design factors, Computers in Nuclear Imaging – Digital image formats – image
acquisition – Image processing in nuclear medicine.
Nuclear Imaging Emission Tomography: Focal plane tomography - Single photon emission
computed tomography (SPECT) – image acquisition – Image reconstruction – attenuation
correction in SPECT, Positron emission tomography – Design and principles of operation – 2-D
and 3-D acquisition – Comparison of SPECT and PET – Combines X-ray CT and SPECT –
Applications: Whole body, Heart and Brain.
TOTAL: 45 PERIODS
REFERENCES:
COURSE OUTCOMES
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 1 2 2 - 2
2 2 2 1 2 - 1
3 3 2 2 3 2
4 1 1 2 2 1 1
5 3 1 2 2 2 2
Low (1); Medium (2); High (3)
36
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Principles of Multimedia - Text, Audio, Video, data, Data communications and networks, PSTN,
POTS, ANT, ISDN, Internet, Air/ wireless communications: GSM satellite, and Micro wave,
Modulation techniques, Types of Antenna, Integration and operational issues, Communication
infrastructure for telemedicine – LAN and WAN technology. Satellite communication. Mobile
hand held devices and mobile communication. Internet technology and telemedicine using
world wide web (www). Video and audio conferencing. Clinical data –local and centralized
Mobile Devices : Smart phones, Tablet PCs, iPads, PDAs, Wearable computers – m-Health
technology and communication infrastructure - Healthcare Apps – m-Health applications:
Education and awareness, Remote data collection, Remote monitoring, Communication and
training for healthcare workers, Disease and epidemic outbreak tracking, Diagnostic and
treatment support – m-Health and the Transformation of Clinical Trials - Harnessing data,
advanced analytics, and the Internet of Things to optimize digitized clinical trials.
Telemedicine access to health care services – health education and self-care. · Introduction to
robotics surgery, telesurgery. Telecardiology, Teleoncology, Telemedicine in neurosciences,
37
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
TOTAL: 45 PERIODS
REFERENCES:
1. Wootton, R., Craig, J., Patterson, V. (Eds.), Introduction to Telemedicine. Royal Society of
Medicine Press Ltd (ISBN 1853156779), 2006.
2. Teresa L. Thompson, Roxanne Parrott, Jon F. Nussbaum, TheRoutledge Handbook of Health
Communication, Routledge, 2011.
3. David Dagan Feng, Biomedical Information Technology, Academic Press Series in Biomedical
Engineering, Elsevier Inc, USA, 2008
4. Ilias G. Maglogiannis, Kostas Karpouzis and Manolis Wallace, Image and Signal Processing for
Networked E-Health Applications, Morgan & Claypool Publishers’ series, USA, 2006.
5. Tuan Bernard Fong, A.C.M. Fong, C.K. Li, Telemedicine Technologies: Information
Technologies in Medicine and Telehealth, Wiley, 2011.
6. Bemmel, J.H. van, Musen, M.A. (Eds.) (1997). Handbook of Medical Informatics. Heidelberg,
Germany: Springer. (ISBN 3-540-63351-0).
7. Ferrer-Roca, O., Sosa-Iudicissa, M. (editors), Handbook of Telemedicine. IOS Press (Studies in
Health Technology and Informatics, Volume 54). (ISBN 90-5199-413-3), 2002.
8. Magnuson, J.A., Fu, Jr., Paul C. (Eds.), Public Health Informatics and Information systems,
ISBN 978-1-4471-4237-9, Springer, 2014
9. Simpson, W. 2006. Video over IP. A practical guide to technology and applications. Focal
Press (Elsevier). ISBN-10: 0-240-80557-7.
COURSE OUTCOMES
After the completion of the course the student will be able to
CO1. Describe the key principles for telemedicine and health
CO2. Understand telemedical technology
CO3. Know Introduce the students with the knowledge of telemedical standards.
CO4. Design and develop m-Health platforms for telemedical applications
CO5. Acquire knowledge of evaluating the force in implants.
CO Pos
PO1 PO2 PO3 PO4 PO5 PO6
1 2 1 - - - -
2 1 1 1 - - -
3 1 1 - - - -
4 2 2 2 3 3 3
5 2 2 2 1 2 3
Low (1); Medium (2); High (3)
38
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Da Vinci Surgical System, Image guided robotic systems for focal ultrasound based surgical
applications, System concept for robotic Tele-surgical system for off-pump, CABG surgery,
Urologic applications, Cardiac surgery, Neuro-surgery, Pediatric and General Surgery,
Gynecologic Surgery, General Surgery and Nanorobotics. Case Study
Pediatric Rehabilitation, Robotic Therapy for the Upper Extremity and Walking, Clinical-Based
Gait Rehabilitation Robots, Motion Correlation and Tracking, Motion Prediction, Motion
Replication. Portable Robot for Tele rehabilitation, Robotic Exoskeletons – Design
considerations, Hybrid assistive limb, cobots. Case Study
Augmented Reality, Kinematics and Dynamics for Wearable Robots, Wearable Robot
technology, Sensors, Actuators, Portable Energy Storage, Human–robot cognitive interaction
(cHRI), Human–robot physical interaction (pHRI), Wearable Robotic Communication - case
study
TOTAL: 45 PERIODS
REFERENCES:
1. Nagrath and Mittal, “Robotics and Control”, Tata McGraw Hill, First edition, 2003
2. Spong and Vidhyasagar, “Robot Dynamics and Control”, John Wiley and Sons, First
edition, 2008
3. Fu.K.S, Gonzalez. R.C., Lee, C.S.G, “Robotics, control”, sensing, Vision and Intelligence, Tata
McGraw Hill International, First edition, 2008
4. Bruno Siciliano, OussamaKhatib, Springer Handbook of Robotics, 1st Edition, Springer,2008
5. Shane (S.Q.) Xie, Advanced Robotics for Medical Rehabilitation - Current State of the Art
and Recent Advances, Springer, 2016
39
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
COURSE OUTCOMES
CO Pos
PO1 PO2 PO3 PO4 PO5 PO6
1 - - - 1 - -
2 - - - 2 - -
3 2 - 2 2 2 2
4 2 - 2 2 3 2
5 2 - 2 2 3 3
Low (1); Medium (2); High (3)
40
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
UNIT I INTRODUCTION 9
Chemical and Biochemical sensors, System design, Challenges in chemical Bio-chemical sensing,
Application areas - Inertia sensors, Parameters from inertia sensors - Applications for wearable
motion sensors - Measurement of energy expenditure by body worn heat flow sensors.
Energy harvesting from human body: Temperature gradient, Foot motion - Wireless energy
transmission - Energy harvesting from light and RF energy - Energy and power consumption
issues, Future considerations.
TOTAL: 45 PERIODS
REFERENCES:
1. Edward Sazonov, Michael R Neuman, "Wearable Sensors: Fundamentals, Implementation
and Applications", Academic Press, USA, 2014.
2. Tom Bruno , "Wearable Technology: Smart Watches to Google Glass for Libraries",
Rowman & Littlefield Publishers, Lanham, Maryland, 2015.
3. Raymond Tong , "Wearable Technology in Medicine and Health Care", Academic Press,
USA, 2018.
4. HaiderRaad , "The Wearable Technology Handbook", United Scholars Publication, USA,
2017.
COURSE OUTCOMES
41
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
CO4. Summarize the techniques and issues associated with energy harvesting from human
body
CO5. Elucidate the applications of wearable technology in health care
CO Pos
PO1 PO2 PO3 PO4 PO5 PO6
1 - 1 2 2 - 2
2 3 2 2 2 - 1
3 3 2 2 1 - 2
4 1 1 2 1 1 2
5 3 1 2 2 - 2
Low (1); Medium (2); High (3)
Achieve familiarity with some basic ethical frameworks & understand how these ethical
frameworks can help us to think through contemporary questions in medical ethics.
Students will be able to know about the legal and ethical principles
To apply these principles in health care settings & gain knowledge about the medical
standards that are to be followed in hospitals.
Definition of Medical ethics, Scope of ethics in medicine, American Medical Association code of
ethics, CMA code of ethics- Fundamental Responsibilities, The Doctor and The Patient, The
Doctor and The Profession, Professional Independence, The Doctor and Society.
Theories-Deontology & Utilitarianism, Casuist theory, Virtue theory, The Right Theory.
Principles-Non- Maleficence, Beneficence, Autonomy, Veracity, Justice. Autonomy &
Confidentiality issues in medical practice, Ethical Issues in biomedical research, Bioethical issues
in Human Genetics & Reproductive Medicine
Life Safety Standards- Protecting Occupants, Protecting the Hospital from Fire, Smoke, and
Heat, Protecting Individuals from Fire and Smoke, Providing and Maintaining Fire Alarm
Systems, Systems for Extinguishing Fires Environment of Care Standards-Minimizing EC Risks,
Smoking Prohibitions, Managing Hazardous Material and Waste, Maintaining Fire Safety
Equipment, Features, Testing, Maintaining, and Inspecting Medical Equipment.
42
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
General requirements for basic safety & essential performance of medical equipment. IEC
60601 standards, Indian and International standards, ISO standards - Base Standard-general
requirement of electrical medical devices, Collateral Standards- EMC radiation protection
&programmable medical device system, Particular Standards-type of medical device.
TOTAL: 45 PERIODS
REFERENCES:
1. Domiel A Vallero, Biomedical Ethics for Engineers, Elsevier Pub.1st edition, 2007
2. Johnna Fisher, Biomedical Ethics: A Canadian Focus., Oxford University Press Canada, 2009.
3. Robert M Veatch, The Basics of Bio Ethics, 3rd Edition. Routledge, 2011.
4. Physical Environment Online: A Guide to The Joint Commission’s Safety Standards is
published by HCPro, Inc. 2010
5. Joint Commission Accreditation Standards for Hospitals, 6th Edition 2018.
6. Ben Mepham, Bioethics-An Introduction for the biosciences, 2nd Edition,
Oxford University Press, 2008.
7. Nils Hoppe and Jose Miola - Medical law and Medical Ethics - Cambridge University Press-
2014
COURSE OUTCOMES
CO Pos
PO1 PO2 PO3 PO4 PO5 PO6
1 1 1 2 - 2 2
2 1 1 2 - 1 1
3 - 1 1 - - 1
4 - 1 1 - - 1
5 - - 1 - 2 2
Low (1); Medium (2); High (3)
43
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Introduction - Brain structure and function, Brain Computer Interface Types - Synchronous and
Asynchronous -Invasive BCI -Partially Invasive BCI - Non Invasive BCI, Structure of BCI System,
BCI Monitoring Hardware, EEG, MEG, fMRI.
Brain activation patterns - Oscillatory potential and ERD, Slow cortical potentials, Movement
related potentials-Mu rhythms, motor imagery, Stimulus related potentials – Visual Evoked
Potentials – P300 and Auditory Evoked Potentials
Data Processing – Spike sorting, Frequency domain analysis, Wavelet analysis, Time domain
analysis, Spatial filtering -Principal Component Analysis (PCA), Independent Component Analysis
(ICA), Artefacts reduction, Feature Extraction - Phase synchronization.
Case Studies - Invasive BCIs: decoding and tracking arm (hand) position, controlling prosthetic
devices such as orthotic hands, Cursor and robotic control using multi electrode array implant,
Cortical control of muscles via functional electrical stimulation. Ethics of Brain Computer
Interfacing.
TOTAL: 45 PERIODS
REFERENCES
44
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
COURSE OUTCOMES
CO Pos
PO1 PO2 PO3 PO4 PO5 PO6
1 1 1 2 - 2 2
2 1 1 2 - 1 1
3 - 1 1 - - 1
4 - 1 1 - - 1
5 - - 1 - 2 2
Low (1); Medium (2); High (3)
MEMS and Microsystems- Introduction - Typical MEMS and microsystem products - Application
of microsystem in healthcare industry - Working principles of microsystems- Microsensors
(Acoustic wave sensor, Biomedical sensor & biosensor, Chemical sensor, Optical sensor,
Pressure sensor, Thermal sensor) – MicroActuation – MEMS with MicroActuation – Micro-
accelerators & Micro-fluidics.
Introduction, Substrates & Wafers, Active Substrate Materials, Silicon as a Substrate Material,
Silicon Compounds, Silicon Piezoresistors, Gallium Arsenide, Quartz, Piezoelectric Crystals,
Polymers, Packaging Materials, Microsystem Fabrication Processes (Elementary idea)
45
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
UNIT V BIOMEMS 9
CO Pos
PO1 PO2 PO3 PO4 PO5 PO6
1 1 1 2 - 2 2
2 1 1 2 - 1 1
3 - 1 1 - - 1
4 - 1 1 - - 1
5 - - 1 - 2 2
Low (1); Medium (2); High (3)
46
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
AUDIT COURSES
AC1A61 ENGLISH FOR RESEARCH PAPER WRITING LTPC
2000
COURSE OBJECTIVES:
Teach how to improve writing skills and level of readability
Tell about what to write in each section
Summarize the skills needed when writing a Title
Infer the skills needed when writing the Conclusion
Ensure the quality of paper at very first-time submission
Planning and Preparation, Word Order, Breaking up long sentences, Structuring Paragraphs and
Sentences, Being Concise and Removing Redundancy, Avoiding Ambiguity and Vagueness
Key skills are needed when writing a Title, key skills are needed when writing an Abstract, key
skills are needed when writing an Introduction, skills needed when writing a Review of the
Literature, Methods, Results, Discussion, Conclusions, The Final Check
Skills are needed when writing the Methods, skills needed when writing the Results, skills are
needed when writing the Discussion, skills are needed when writing the Conclusions
Useful phrases, checking Plagiarism, how to ensure paper is as good as it could possibly be the
first- time submission
TOTAL: 30 PERIODS
REFERENCES:
1. Adrian Wallwork , English for Writing Research Papers, Springer New York Dordrecht
Heidelberg London, 2011
2. Day R How to Write and Publish a Scientific Paper, Cambridge University Press 2006
3. Goldbort R Writing for Science, Yale University Press (available on Google Books) 2006
4. Highman N, Handbook of Writing for the Mathematical Sciences, SIAM. Highman’s book 1998.
COURSE OUTCOMES:
CO1 : Understand that how to improve your writing skills and level of readability
CO2 : Learn about what to write in each section
CO3 : Understand the skills needed when writing a Title
CO4 : Understand the skills needed when writing the Conclusion
CO5 : Ensure the good quality of paper at very first-time submission
47
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
UNIT I INTRODUCTION 6
Disaster: Definition, Factors and Significance; Difference between Hazard And Disaster; Natural and
Manmade Disasters: Difference, Nature, Types and Magnitude.
Economic Damage, Loss of Human and Animal Life, Destruction Of Ecosystem. Natural Disasters:
Earthquakes, Volcanisms, Cyclones, Tsunamis, Floods, Droughts And Famines, Landslides And
Avalanches, Man-made disaster: Nuclear Reactor Meltdown, Industrial Accidents, Oil Slicks And Spills,
Outbreaks Of Disease And Epidemics, War And Conflicts.
Study of Seismic Zones; Areas Prone To Floods and Droughts, Landslides And Avalanches; Areas Prone
To Cyclonic and Coastal Hazards with Special Reference To Tsunami; Post-Disaster Diseases and
Epidemics
Disaster Risk: Concept and Elements, Disaster Risk Reduction, Global and National Disaster Risk
Situation. Techniques of Risk Assessment, Global Co-Operation in Risk Assessment and Warning,
People’s Participation in Risk Assessment. Strategies for Survival
TOTAL : 30 PERIODS
REFERENCES:
1. Goel S. L., Disaster Administration And Management Text And Case Studies”,Deep & Deep
Publication Pvt. Ltd., New Delhi,2009.
2. NishithaRai, Singh AK, “Disaster Management in India: Perspectives, issues and strategies
“NewRoyal book Company,2007.
3. Sahni, PardeepEt.Al. ,” Disaster Mitigation Experiences And Reflections”, Prentice Hall Of
India, New Delhi,2001.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
COURSE OUTCOMES:
Fundamental Rights, Right to Equality, Right to Freedom, Right against Exploitation, Right to Freedom
of Religion, Cultural and Educational Rights, Right to Constitutional Remedies, Directive Principles of
State Policy, Fundamental Duties.
District’s Administration head: Role and Importance, Municipalities: Introduction, Mayor and role of
Elected Representative, CEO, Municipal Corporation. Pachayati raj: Introduction, PRI: Zila Pachayat.
Elected officials and their roles, CEO Zila Pachayat: Position and role. Block level: Organizational
Hierarchy(Different departments), Village level:Role of Elected and Appointed officials, Importance of
grass root democracy.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Election Commission: Role and Functioning. Chief Election Commissioner and Election Commissioners
- Institute and Bodies for the welfare of SC/ST/OBC and women.
TOTAL: 30 PERIODS
COURSE OUTCOMES:
SUGGESTED READING
1. The Constitution of India,1950(Bare Act),Government Publication.
2. Dr.S.N.Busi, Dr.B. R.Ambedkar framing of Indian Constitution,1st Edition, 2015.
3. M.P. Jain, Indian Constitution Law, 7th Edn., Lexis Nexis,2014. 4. D.D. Basu, Introduction to
the Constitution of India, Lexis Nexis, 2015.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
51
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
SEMESTER - III
BM1381 HOSPITAL / BIOMEDICAL INDUSTRY TRAINING L T P C
0 0 4 2
COURSE OBJECTIVES:
To provide hands-on experience at site where biomedical equipment’s are manufactured (industry) and
utilized (Hospitals)
SYLLABUS:
An industrial training of minimum two weeks has to be undergone by the student in the III semester. They
can choose either one of the following: Biomedical Industry, Multispecialty Hospital, Government
Medical Hospital and Private/Government R&D Medical Division. After the training, they have to submit a
report in the given prescribed format along with a copy of the certificate. During final examination,
student has to give a power point presentation about the training.
TOTAL: 60 PERIODS
COURSE OUTCOME:
At the end of the course, the student should be able to:
CO1: Get experience on various biomedical equipment’s used in hospitals
CO2: Get experience on biomedical equipment manufacturing.
CO3: Get practical knowledge of design and develop prosthetics and orthotics, drugs discovery and
Computer Aided System.
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 - 3 2 1 1
2 2 - 3 2 1 1
3 3 3 2 3 3 3
Low (1); Medium (2); High (3)
SYLLABUS:
The student individually works on a specific topic of their area of interest, which is approved by faculty
member. The topic may be hardware, experimental or analytical and to analysis the ethical responsibility.
Methodology can be identified through detailed literature review based on the topic chosen to solve the
real time problem by the student. The students are trained to prepare the report and manuscript. The
students will be evaluated through a viva-voce examination by a panel of examiners including one external
examiner.
TOTAL: 180 PERIODS
COURSE OUTCOME:
1
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 3 1 2 3 2 2
2 3 - 3 3 2 2
3 2 3 2 1 3 1
4 - 3 - - 2 -
Low (1); Medium (2); High (3)
SEMESTER IV
The student should continue the phase I work on the selected topic as per the formulated
methodology/ Undergo internship. The students should analyses the results of clinical trial/ validation
output taken from mentioned real time problem. At the end of the semester, after completing the
work to the satisfaction of the supervisor and review committee, a detailed report should be
prepared and submitted to the head of the department. The students will be allowed to submit
his/her project work in the form of paper for presentation/ publication in a conference/ journal and
produce the proof of acknowledgement of receipt of paper from the organizers/ publisher. The
students will be evaluated based on the report and the viva-voce examination by the panel of
examiners including one external examiner.
COURSE OUTCOME:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 3 1 3 3 1 2
2 3 3 3 3 3 2
3 2 3 - 1 - 1
Low (1); Medium (2); High (3)
2
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Basic concepts marketing, Principles of social marketing, Social marketing in the health sector,
Consumer behavior and research health, Advertising in Health Sector, Relevance of e-marketing
of Health care services.
System Development life cycle, Reasons to use computers in hospital, main categories of
information systems in hospitals.
TOTAL: 45 PERIODS
REFERENCES
1. Goyal R.C., Human Resource Management in Hospital, Prentice Hall of India Pvt. Ltd., New
Delhi, 2000.
2. Koontz, Essentials of Management, McGraw Hill, 11th edition 2020.
3. G. D. Kunders Hospitals: Facilities Planning and Management, Tata McGrawHill Education,
New Delhi, 2004
4. Syed Amin Tabish, Hospitals & Nursing Homes: Planning, Organisations& Management,
Jaypee Brothers Medical Publishers (P) Limited, 2003
COURSE OUTCOMES:
CO1: Understand the Roles and types of establishment.
CO2: Discuss the functions of hospital management.
CO3: Understand the concepts of HR Management practices.
CO4: Discuss the methods and tools of marketing.
CO5: Understand the impacts of Information technology in hospital management
3
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 - 1 - 1 -
2 1 - 1 - 2 -
3 - 1 1 - 1 -
4 - - 1 - 1 -
5 1 - 1 1 2 1
Low (1); Medium (2); High (3)
This subject acquaints the students with major functions of HRM aligned with the business
strategy.
The subject encompasses the concept of best fit employee, training & executive
development, sustaining employee interest and performance appraisal
Organizational Job Design - job description - job analysis - job rotation-job evaluation- Man-
power planning- Importance of Human Resource Planning, Forecasting of Human Resource
Requirements in Health Care - Selection procedures - test, Validation, Interviews, Recruitment,
Medical Examination.
Types of Training methods and their benefits - Executive development Programme - common
practices - Benefits, self-development - knowledge Management.
Wage and Salary Administration – the concept of incentives and its operational implications –
Participative decision making – Concept of Collective Bargaining – Compensation plans – Rewards
– Motivation – Theories of motivation - Grievances and redressal methods.
4
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
REFERENCES
COURSE OUTCOMES:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 - - 1 - 1 -
2 1 1 1 - 2 -
3 - - 1 - 1 1
4 - - - - 1 1
5 - 1 1 1 2 1
Low (1); Medium (2); High (3)
UNIT I INTRODUCTION 9
Medical waste stream, different types of medical waste, its source of origin. Waste management
elements – categories of bio-medical waste, different colour codes and symbols –rules and
regulation includes state and national level bodies.
Disease and its mode of transmission - Disinfection methods- concept and mechanism – role of
CSSD in hospital, physical sterilization and chemical sterilization – Large scale autoclave -
Microwave (Non-burn treatment technology).
Disposal methods – Incinerator and its types-hazardous waste, radioactive waste, liquid waste
destruction – landfill and rules governing landfill.
5
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Air pollution and emission control, rules governing pollution, instrumentation and monitoring,
emission filters and its types, crematories- gas emission control device. Case studies related to
air pollution.
COURSE OUTCOMES:
On completion of this course the student will be able to:
CO1: Get a clear understanding of regulations framed for waste management
CO2: Understand the significance of infections and the transmission of diseases
CO3: Acquire knowledge on proper disposal of waste
CO4: Acquire a conceptual idea about the controls applied to waste management.
CO5: Gain sufficient knowledge on Risk analysis and management of public issues.
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 1 2 - - 1
2 1 1 2 1 1 1
3 - 1 1 - 1 1
4 1 1 1 1 1 1
5 1 1 1 1 2 2
Low (1); Medium (2); High (3)
Define Quality- Need for Standardization & Quality Management, TQM in Health care
organization-Quality assurance methods, QA in (Medical Imaging & Nuclear medicine) Diagnostic
services – Classification of equipment
FDA regulations, Accreditation for hospitals - JCI, NABH and NABL, IEC 60601 and AERB
regulatory, other regulatory Codes.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Sources of shocks, macro & micro shocks -Hazards, monitoring and interrupting the Operation
from leakage current- Elements of fire, causes of fire, Action to be taken in case of fire in a
Hospital.
TOTAL: 45 PERIODS
REFERENCES
1. B.M.Sakharkar, Principles of Hospital Administration and Planning, JAYPEE Brothers,
Medical Publishers (P) Ltd 2009.
2. Cesar A. Cacere& Albert Zana, The Practice of Clinical Engg. Academic Press, New York,
2012.
3. Joseph F Dyro “Clinical Engineering Handbook “ Elsevier Publishers,2004.
4. K.Shridhara Bhat, Quality Management, Himalaya Publishing House.
5. Karen Parsley, Karen Parsley Philomena Corrigan”Quality improvement in Healthcare,
edition, Nelson Thrones Pub,2002
6. Sharon Myers “Patient Safety & Hospital Accreditation - A Model for Ensuring Success”
Springer Publishers 2012
COURSE OUTCOMES:
On completion of this course the student will be able to:
CO1: Understand the scope of Need and significance of quality practices in health
care industry
CO2: Discuss the system of regulatory measures and accreditation
CO3: Differentiate the level of safety and security measures and significance
CO4: Understand the concepts of Electrical and Fire Safety Hazards Mitigations
CO5: Understand the assessing quality practices using tools.
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 - 1 - 1 1
2 1 2 1 - 2 1
3 1 - 1 - - -
4 - - 1 - - -
5 1 1 1 1 1 1
Low (1); Medium (2); High (3)
7
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
History and scope of tissue engineering – Scientific and Social Challenges - Structure and
organization of Tissues – Development of Tissue – Cell and Extracellular matrix interaction –
Morphogenesis and Tissue Engineering – Cell Determination and Differentiation.
Cell adhesion, Cell migration and Cell aggregation – Cell growth and Cell cycle. Cellular
Interactions: Cell – Cell and Cell – Matrix. Control of Cell migration in Tissue Engineering –Cell
delivery and Recirculation – Cell Culture in vitro – 3D culture in Tissue Engineering - In vitro
Organogenesis - Cell transplantation.
Biological vs Nonbiological materials – Extra Cellular Matrix – Collagen, Chitin & Degradable and
Nondegradable materials – Polymer, Ceramics and Metals – Cell interaction with different
materials –- Scaffolds - Control releaser agents in Tissue Engineering – Cell interaction with
suspension and gels – Tissue response to implants.
Introduction of Stem cells – Hemopoetic Stem cells - Embryonic Stem cells - Adult stem cells –
Cancer Stem cells – Cord Blood cells – Induced Pluripotent Stem cells - Stem cell identification -
Surface markers & FACS analysis – Differentiation, Dedifferentiation and Immortalization –
Application of stem cells in tissue Engineering.
Synthetic components – Artificial organs – Joints and dental prostheses - Connective Tissue
Engineering – Cardiovascular Tissue Engineering – Neural Tissue Engineering - Cell and Drug
Delivery systems.
TOTAL : 45 PERIODS
REFERENCES
1. R.Lanza, J.Gearhart et.al,(Eds), Essential of Stem cell Biology, Elsevier Academic Press, 2nd
edition 2009.
2. Robert P. Lanza, Robert Langer and Joseph Vacanti., Principles of Tissue Engineering, 2nd
Edition, Academic press, Elsevier 2013.
3. Gary E Wnek, Gary L Browlin – Encyclopedia of Biomaterials and Biomedical Engineering
– Marcel Dekker Inc New York, 2nd edition, 2008.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
COURSE OUTCOMES:
CO1: Explain the mechanisms involved in interaction of different materials with cells and tissues
CO2: Explain different methods involved in characterization and preparation of biomaterials in
tissue engineering
CO3: Apply the knowledge in creating new models in drug delivery systems using synthetic and
natural scaffolds
CO4: Explain different types of stem cells and its application in tissue engineering
CO5: Develop new approaches to build new tissues using tissue engineering techniques
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 3 1 2 1 2
2 2 2 1 1 1 2
3 2 2 2 1 2 1
4 2 2 2 1 2 1
5 2 2 2 3 2 2
Low (1); Medium (2); High (3)
COURSE OBJECTIVES
To provide adequate technical information on operating principles of medical instruments
to attain mastery in fault detection and corrective measures.
To learn fundamental trouble shooting procedures.
To learn how to test passive & semiconductor.
To be able to drapnoze faults in analog and digital I C S devices
To be able to trouble shoot Biomedical equipments.
Different types of resistors - Capacitors, Inductors and their testing procedures - Types of
Semiconductor & its causes of failure - testing procedure for semiconductor devices - special
diodes, Bipolar Transistors, Field effect transistor (FET), Thyristors, IGBT
9
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Trouble shooting - ECG Machine, EEG Machine, Defibrillator Electrosurgical Unit, Anaesthesia
Machine, Autoclaves & sterilizers, Endoscopes.
CASE STUDIES
1. Develop an in-house computerized maintenance management system for hospitals.
2. Human Resources for medical Devices.
TOTAL: 45 PERIODS
REFERENCES
1. R S Khandpur, ‘Troubleshooting Electronic Equipment- Includes Repair & Maintenance’,
Tata McGraw-Hill, Second Edition 2009
2. Dan Tomal& Neal Widmer, ‘Electronic Troubleshooting’, McGraw Hill, 3rd Edition 2004
3. Nicholas Cram & Selby Holder, ‘Basic Electronic Troubleshooting for Biomedical
Technicians’, TSTC Publishing, 2nd Edition 2010
4. Ian R McClelland , ‘X-ray Equipment maintenance & repairs workbook for Radiographers
& Radiological Technologists’, World Health Organization,Geneva, 2004
5. Ministry of Health & Family Welfare, ‘Medical Equipment Maintenance Manual- A first
line maintenance guide for end users’, New Delhi, October2010
COURSE OUTCOMES:
CO1: To be able to calibrate and assist in equipment maintenance.
CO2: To be able to provide on and off- site assistance with the functioning of the medical
equipments.
CO3: To be able to perform as a member of multidisciplinary team in a hospital setting
CO4: Solve basic circuit problems involving DC and AC circuits
CO5: Describe the theory of operation, functioning and clinical application of medical devices
CO POs
10
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
ARM organization and implementation, The Thumb Instruction Set, Architectural Support for
High-Level Languages. Introduction to Arduino Due; Arduino integrated development
environment and programming.
Basics of hardware design and functions of basic passive components-sensors and actuators,
Arduino code - library file for sensor interfacing-construction of basic applications
UNIT V EMBEDDED WEB-SERVER & IOT CLOUD SERVICES APPLICATION DESIGN & CASE STUDY 9
Embedded web server: Basic introduction, its importance and role in IOT. Design of a simple
embedded web server: understand the HTTP & HTML basics Overview of different IOT Cloud
Services.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
1. Code for Sensor interface: Temperature sensor, pressure sensor, Light sensor, IR sensor.
2. Temperature sensor Interfacing using ARM processor
3. Flashing of LEDs using ARM processor
4. ADC/DAC Interfacing using ARM processor
5. EPROM Interfacing using ARM processor.
6. Study of basic image processing algorithm using Single board computers such as Raspberry
Pi, Beagle Bone block etc
TOTAL: 30 PERIODS
TOTAL: 75 PERIODS
REFERENCES
1. Muhammad Ali Mazidi, Janice GillispieMazidi, Rolin D. McKinlay, “The 8051 microcontroller
and embedded systems using assembly and C”, 2nd Edition, Pearson, 2005.
2. Andrew Sloss, Dominic Symes, Chris Wright, ARM system developer’s guide: designing and
optimizing system software, Morgan Kaufmann, 2004.
3. S. Salivahanan, S.Arivazhagam, “Digital circuits and Design”, 4th Edition, Vikas Publishing
House, 2012.
4. R. S. Khandpur, “Printed Circuit Boards Design - Fabrication, Assembly and Testing”,
1stEdition, McGraw Hill Education, 2017.
5. Getting Started with Internet of Things- CunoPfister, 2011
6. Interconnecting Smart Objects with IP- J. P Vasseur, Adam Dunkels, 2010 24 Course
COURSE OUTCOMES:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 3 2 3 3 1 3
2 2 1 1 2 - -
3 3 1 3 2 - 2
4 3 2 3 3 2 3
5 3 2 3 3 2 3
Low (1); Medium (2); High (3)
12
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Introduction to Operating systems, Linux commands, File transfer protocols ftp and telnet – Search
Engine – Online Medical Resources – Electronic Health Records - Network - Evolution of Medical
Standards – IEEE 11073 - HL7 – DICOM – IRMA - LOINC – HIPPA
Data management – data life cycle – database technology – interfaces and implementation –
biological databases and their uses – Database management system models, Basics of Structured
Query Language (SQL). Genome projects, Clinical informatics, Nursing informatics, Public health
informatics
Representation of Data, Data modeling Techniques, Relational Hierarchical and network Approach,
Normalization techniques for Data handling - Plug-in Data Acquisition and Control Boards – Data
Acquisition using Serial Interface – Medical Data formats – Signal, Image and Video Formats –
Medical Databases - Automation in clinical laboratories - Intelligent Laboratory Information System
– PACS
Medical Expert Systems, Virtual reality applications in medicine, Virtual Environment – Surgical
simulation - Telemedicine – virtual Hospitals - Smart Medical Homes – Personalized e-health services
– Biometrics - GRID and Cloud Computing in Medicine – Artificial Intelligence in health informatics.
TOTAL: 45 PERIODS
PRACTICAL EXERCISES:
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
REFERENCES
1. OrpitaBosu and Simminder Kaur Thukral, “Bioinformatics Databases, Tools and Algorithms”
Oxford University press, 2007
2. Yi Ping Phoebe Chen, “Bioinformatics Technologies”, Springer International Edition, New
Delhi, 2007.
3. R.D.Lele, “Computers in medicine progress in medical informatics”, Tata McGraw Hill
Publishing Ltd, 2005
4. Mohan Bansal, “Medical informatics”, Tata McGraw Hill Publishing Ltd, 2003
5. J.H. van Bemmel and M.A. Musen. Handbook of Medical Informatics. Bohn Stafleu Van
Loghum,. Springer
6. Robert E. Hoyt. Medical Informatics. Practical Guide for the Healthcare Professional.
Published by: Lulu.com
COURSE OUTCOMES:
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 2 3 3 2 -
2 3 3 3 3 2 2
3 2 3 3 3 2 3
4 2 3 3 3 3 2
5 2 3 3 3 3 3
6 3 3 3 3 2 2
Low (1); Medium (2); High (3)
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
UNIT II CLUSTERING 9
State Machines – Hidden Markov Models: Maximum Likelihood for the HMM, Forward-
Backward Algorithm, Sum and Product Algorithm for the HMM, Extensions of the Hidden
Markov Model – Support Vector Machines: Maximum Margin Classifiers, Relevance Vector
Machines
Elementary Neural Network for Pattern Recognition, Fuzzy pattern classifier, Application of PR
in image segmentation, CAD system in breast cancer detection, ECG signal classification,
Fingerprint recognition, cell cytology classification
TOTAL: 45 PERIODS
PRACTICAL EXERCISES:
1. Implementation of Perceptron Image classification using Matlab/python
2. Implementation of Fuzzy pattern classifier in Matlab/OpenCV/python.
3. Implementation of Feature extraction using KL transform in Matlab/OpenCV/python.
4. Implementation of partitional clustering in Matlab/OpenCV/python.
5. Implementation of density based clustering in Matlab/OpenCV/ python
6. Implementation of Classification using SVM in Matlab/OpenCV/python.
7. Implementation of Classification using HMM in Matlab/OpenCV/python.
8. Implementation of Bayes classifier in Matlab/OpenCV/python.
9. Implementation of Classification using Neural Networks in
10.Implementation of image segmentation in Matlab/OpenCV/python
TOTAL: 30 PERIODS
TOTAL:75 PERIODS
REFERENCES
6. S.Theodoridis and K.Koutroumbas, “Pattern Recognition”, 4th Edition, Academic Press, 2008
COURSE OUTCOMES:
On completion of this course the student will be able to:
CO1: Perform classification using Bayes approach
CO2: Implement clustering algorithms for classification
CO3: Perform Feature extraction, feature reduction
CO4: Apply HMM and SVM for real time applications
CO5: Apply pattern recognition techniques for biosignal and medical image applications
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 - - 2 2 -
2 1 - - 2 2 -
3 2 - - 3 2 -
4 2 - - 3 1 2
5 2 - 2 3 3 2
Low (1); Medium (2); High (3)
UNIT I INTRODUCTION 9
Introduction to Healthcare Data Analytics- Electronic Health Records–Components of EHR- Coding
Systems- Benefits of EHR- Barrier to Adopting EHR-Challenges- Phenotyping Algorithms.
Natural Language Processing and Data Mining for Clinical Text- Mining the Biomedical -Social Media
Analytics for Healthcare.
Advanced Data Analytics for Healthcare– Review of Clinical Prediction Models- Temporal Data
Mining for Healthcare Data- Visual Analytics for Healthcare- Predictive Models for Integrating
Clinical and Genomic Data- Information Retrieval for Healthcare- Privacy- Preserving Data Publishing
Methods in Healthcare
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
UNIT V APPLICATIONS 9
Applications and Practical Systems for Healthcare– Data Analytics for Pervasive Health- Fraud
Detection in Healthcare- Data Analytics for Pharmaceutical Discoveries- Clinical Decision Support
Systems- Computer-Assisted Medical Image Analysis Systems- Mobile Imaging and Analytics for
Biomedical Data.
TOTAL: 45 PERIODS
PRACTICAL EXERCISES:
1. Chandan K. Reddy and Charu C Aggarwal, “Healthcare data analytics”, Taylor & Francis,
2015
2. Hui Yang and Eva K. Lee, “Healthcare Analytics: From Data to Knowledge to Healthcare
Improvement, Wiley, 2016.
3. Michael Berthold, David J.Hand, “Intelligent Data Analysis”, Springer, 2007.
4. David J. Lubliner , "Biomedical Informatics: An Introduction to Information Systems and
Software in Medicine and Health", CRC Press, Boca Raton, 2016
COURSE OUTCOMES:
CO1: Understand about health care analytics and benefits of Electronic health records.
CO2: Understand about Bio medical image analysis
CO3: Understand about Natural language processing and biomedical mining
CO4: Understand about information retrieval for health care.
CO5: Demonstrate about applications and practical systems for health care
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 1 2 2 1 2
2 2 1 2 2 2 1
3 2 1 2 3 1 2
4 2 1 2 2 1 1
5 - 1 - 1 3 2
Low (1); Medium (2); High (3)
17
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Introduction, Fundamental Concept and Components of Virtual Reality. Primary Features and
Present Development on Virtual Reality. Computer graphics, Real time computer graphics, Flight
Simulation, Virtual environment requirement, benefits of virtual reality, Historical development of
VR, Scientific Landmark 3D Computer Graphics: Introduction, The Virtual world space, positioning
the virtual observer, the perspective projection, human vision, stereo perspective projection, 3D
clipping, Colour theory, Simple 3D modelling, Illumination models, Reflection models, Shading
algorithms, Radiosity, Hidden Surface Removal, Realism Stereographic image.
Suggested Activities:
Flipped classroom on uses of MR applications.
Videos – Experience the virtual reality effect.
Assignment on comparison of VR with traditional multimedia applications.
Suggested Evaluation Methods:
Tutorial – Applications of MR.
Quizzes on the displayed video and the special effects
Suggested Activities:
Flipped classroom on modeling three dimensional objects.
External learning – Collision detection algorithms.
Practical – Creating three dimensional models.
Animating the Virtual Environment: Introduction, The dynamics of numbers, Linear and Nonlinear
interpolation, the animation of objects, linear and non-linear translation, shape & object
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
inbetweening, free from deformation, particle system. Physical Simulation: Introduction, Objects
falling in a gravitational field, Rotating wheels, Elastic collisions, projectiles, simple pendulum,
springs, Flight dynamics of an aircraft.
Suggested Activities:
External learning – Different types of programming toolkits and Learn different types of
available VR applications.
Practical – Create VR scenes using any toolkit and develop applications.
Suggested Evaluation Methods:
Taxonomy, technology and features of augmented reality, difference between AR and VR,
Challenges with AR, AR systems and functionality, Augmented reality methods, visualization
techniques for augmented reality, wireless displays in educational augmented reality applications,
mobile projection interfaces, marker-less tracking for augmented reality, enhancing interactivity in
AR environments, evaluating AR systems
Suggested Activities:
External learning - AR Systems
Human factors: Introduction, the eye, the ear, the somatic senses. VR Hardware: Introduction,
sensor hardware, Head-coupled displays, Acoustic hardware, Integrated VR systems. VR Software:
Introduction, Modeling virtual world, Physical simulation, VR toolkits, Introduction to VRML, Input -
- Tracker, Sensor, Digitalglobe, Movement Capture, Video-based Input, 3D Menus and 3DScanner
etc. Output -- Visual /Auditory / Haptic Devices. VR Technology in Film & TV Production. VR
Technology in Physical Exercises and Games. Demonstration of Digital Entertainment by VR.
Suggested Activities:
External learning – Different types of sensing and tracking devices for creating mixed
reality environments.
Practical – Create MR scenes using any toolkit and develop applications.
Suggested Evaluation Methods:
Tutorial – Mobile Interface Design.
Brainstorming session on wearable computing devices and games design.
Demonstration and evaluation of the developed MR application.
TOTAL: 45 PERIODS
PRACTICALS:
1. Study of tools like Unity, Maya, 3DS MAX, AR toolkit, Vuforia and Blender.
2. Use the primitive objects and apply various projection methods by handling the camera.
3. Download objects from asset stores and apply various lighting and shading effects.
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
4. Model three dimensional objects using various modeling techniques and apply textures
over them. Create three dimensional realistic scenes and develop simple virtual reality
enabled mobile applications which have limited interactivity.
5. Add audio and text special effects to the developed application.
6. Develop VR enabled applications using motion trackers and sensors incorporating full
haptic interactivity.
7. Develop AR enabled applications with interactivity like E learning environment,
Virtual walkthroughs and visualization of historic places.
8. Develop MR enabled simple applications like human anatomy visualization,
DNA/RNA structure visualization and surgery simulation.
9. Develop simple MR enabled gaming applications.
TOTAL: 30 PERIODS
TOTAL: 75 PERIODS
REFERENCES
1. Burdea, G. C. and P. Coffet. Virtual Reality Technology, Second Edition. Wiley-IEEE Press,
2003/2006.
2. Alan B. Craig, Understanding Augmented Reality, Concepts and Applications, Morgan
Kaufmann,First Edition 2013.
3. Alan Craig, William Sherman and Jeffrey Will, Developing Virtual Reality Applications,
Foundations of Effective Design, Morgan Kaufmann, 2009.
4. John Vince, “Virtual Reality Systems “, Pearson Education Asia, 2007.
5. Adams, “Visualizations of Virtual Reality”, Tata McGraw Hill, 2000.
6. Grigore C. Burdea, Philippe Coiffet , “Virtual Reality Technology”, Wiley Inter Science, 2nd
Edition, 2006.
7. William R. Sherman, Alan B. Craig, “Understanding Virtual Reality: Interface, Application and
Design”, Morgan Kaufmann, 2008
COURSE OUTCOMES:
CO1: Understand the Fundamental Concept and Components of Virtual Reality
CO2: Able to know the Interactive Techniques in Virtual Reality
CO3: Can know about Visual Computation in Virtual Reality
CO4: Able to know the concepts of Augmented and Mixed Reality and Its Applications
CO5: Know about I/O Interfaces and its functions.
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 1 2 3 3 2
2 3 3 3 3 2 2
3 2 3 3 3 2 3
4 2 3 3 3 3 2
5 2 3 3 3 3 3
Low (1); Medium (2); High (3)
20
PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
Model- Definition, various analogs, Physiological systems-A simple example, Generalized system
properties- Resistance, Compliance, Impedance, Across variable, through Variable, Models with
combination of system elements, Linear- vs nonlinear- models of physiological systems, Action
potentials Hodgkin-Huxley model by MATLAB tools, Distributed Vs Lumped parameter models,
Compartment models
Frequency domain- Linearized model of lungs mechanics and their SIMULINK implementation,
model of chyne-stokes breathing, circulatory control model, cardiac output, glucose insulin
regulation model by MATLAB tools, transient response analysis of neuromuscular reflex model
action by MATLAB tools.
Mechanical modeling of bone and tissues, linear muscle model, Study of steady state analysis of
muscle stretch reflex action by MATLAB tools, Hills’ model of muscle contraction, Oculomotor
muscle model, modeling of human movements, Pharmacokinetic modeling with drug diffusion as
example
Eye movement system and Wetheimer’s saccade eye model, closed loop aspects of papillary control
system, Open loop papillary response of papillary-retinal system, Homeostatic lumped model of
physiological thermal system, models of heat transfer between subsystems of human body,
Homeostatic control of adrenocortical secretion.
Non parametric models- Volterra models, Wiener models, Parametric Models – Basic parametric
model forms and estimation procedures, Volterra Kernels of non linear differential equations,
Discrete time Volterra Kernels of NARMAX models.
TOTAL: 45 PERIODS
PRACTICALS:
1. SIMULINK model of simple lung mechanics
2. Simulation of Hodgkin – Huxley model of nerve membrane
3. Steady state analysis of muscle stretch reflex model
4. SIMULINK model to determine the steady state operating point of the ventilator control system
5. Second order lung mechanics model to a unit impulse
6. SIMULINK implementation of neuromuscular reflex model
7. SIMULINK model of circulatory control
8. SIMULINK model of blood glucose-insulin regulations
9. Frequency responses of the linearized ventilator control by Nyquist plots
10. Cardiovascular variability model with feedback
TOTAL: 30 PERIODS
TOTAL: 75 PERIODS
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PSNACET (Autonomous), Dindigul -624 622 Regulations 2022 ME BME
REFERENCES
1. William B. Blesser, “A System approach to Bio-medicine”, McGraw-Hill book co., New York, 2nd
Edition, 1981
2. Michael C. K. Khoo, “Physiological control systems: Analysis, Simulation and Estimation”,
Prentice-Hall of India Pvt. Limited, first edition, 2000.
3. Manfreoclynes and john H.Milsum, “Bio-medical engineering system” McGraw-Hill book co.,
NewYork, first edition, 1970.
4. Douglas S. Regs, “Control theory and physiological feedback mechanism” The William &Williams
co., Baltimore, first edition, 1970.
5. Simpson, W. 2006. Video over IP. A practical guide to technology and applications. Focal Press
(Elsevier). ISBN-10: 0-240-80557-7.
COURSE OUTCOMES:
CO1: Explain the application of Physiological models and vital organs
CO2: Formulate the methods and techniques for analysis and synthesis of dynamic models
CO3: Describe the dynamic models, simulate and visualize, dynamic responses of physiological
models using software
CO4: Describe nonlinear models of physiological systems
CO5: Compute the Simulation of physiological systems
CO POs
PO1 PO2 PO3 PO4 PO5 PO6
1 2 1 - - - -
2 1 1 1 - - -
3 1 1 - - - -
4 2 2 2 3 3 3
5 2 2 2 1 2 3
Low (1); Medium (2); High (3)
22