Immediate Implant
Immediate Implant
P lac e me n t
Surgical Techniques for Prevention and
Management of Complications
a, b
Mohanad Al-Sabbagh, DDS, MS *, Ahmad Kutkut, DDS, MS
KEYWORDS
Immediate implant placement Complications of immediate placement
Techniques for immediate placement Prevention of complications
KEY POINTS
Clinical studies have reported successful outcome of immediate placement of dental im-
plants in fresh extraction sockets.
Although immediate implant placement has advantages over delayed implant placement,
like any other procedure, it is associated with risks and complications.
Case selection and evaluation of patient-related and implant-related factors are keys to
the success of immediate implant placement.
A thorough discussion between practitioner and the patient is indispensable to discern
patient’s desires.
INTRODUCTION
Healing of Extraction Socket
Wound healing in an extraction socket is characterized by resorption of alveolar bone,
which may result in restorative complications.1,2 Healing of extraction sites when no
socket preservation techniques are used results in the resorption of an average of 1
to 2 mm of vertical alveolar bone height and an average of 4 to 5 mm of horizontal alve-
olar bone width. Most of this bone loss occurs during the first year after extraction, and
two thirds of this bone loss occurs within the first 3 months after extraction. Therefore,
preservation of alveolar bone immediately after tooth extraction has an important
impact on the functional and esthetic outcomes of subsequent prosthetic treatment.2
The purpose of preserving the extraction socket is to maintain the architecture of the
a
Division of Periodontology, Department of Oral Health Practice, College of Dentistry, Univer-
sity of Kentucky, 800 Rose Street, Lexington, KY 40536, USA; b Division of Restorative Dentistry,
Department of Oral Health Practice, College of Dentistry, University of Kentucky, 800 Rose
Street, Lexington, KY 40536, USA
* Corresponding author.
E-mail address: [email protected]
alveolar bone, prevent soft tissue collapse, and minimize or eliminate the need for
future bone augmentation procedures.
Histologically, 4 important changes may occur during the 5 stages of normal healing
of the extraction site: External dimensional changes at the extraction socket, internal
dimensional changes within the extraction socket, dimensional changes in a damaged
extraction socket, and dimensional changes in the mucosa. The first stage of healing is
characterized by the formation of a blood clot as a coagulum of red and white blood
cells. The second stage is characterized by the formation of granulation tissue, which
replaces the clot over 4 to 5 days. The third stage is characterized by the formation of
connective tissue, which replaces granulation tissue over 14 to 16 days. The fourth
stage is characterized by the appearance of osteoid calcification, which begins at
the base and the periphery of the socket (early osteoid calcification is present within
7–10 days, and trabecular bone fills the socket by 6 weeks). The fifth stage is charac-
terized by complete epithelial closure of the socket after 24 to 35 days (bone filling oc-
curs between 5 and 10 weeks, and complete filling occurs by 16 weeks). Maximum
osteoblastic activity occurs within 4 to 6 weeks.3,4
External dimensional changes at the extraction socket consist of horizontal or buc-
colingual ridge reduction of approximately 5 to 7 mm (almost 50% of the initial ridge
width); this reduction occurs over a period of 6 to 12 months, although most of the
changes occur during the first 3 months. Reduction in the apicocoronal or vertical
height of 2.0 to 4.5 mm accompanies the horizontal change. Internal dimensional
changes within extraction sockets, consisting of a reduction of 3 to 4 mm in the vertical
height of the socket, or approximately 50% of the initial socket height, have been re-
ported after 6 months of healing. Most of this bone loss occurs during the first
3 months after tooth extraction. Dimensional changes in damaged extraction sockets
most likely consist of fibrous tissue that may occupy a portion of the socket, thereby
preventing normal healing and osseous regeneration.5
Elevating the flap after extraction may compromise the blood supply of the thin
buccal plate, which has little or no cancellous bone, resulting in partial or complete
resorption of the buccal plate. At the surgically treated tooth site (full-thickness flap
elevation) in dogs, the mean amount of bone loss is 1.0 mm buccal and 0.1 mm lingual.
Surface bone resorption has a more pronounced effect on the delicate buccal bone
than on the lingual bone.6
Fig. 1. (A) Thick buccal bone (arrow) of an extraction socket. (B) Thin buccal bone (arrow) of
an extraction socket.
Immediate Implant Placement 75
of the buccal plate of socket are frequently present. There are 3 main sources of blood
supply to the alveolar bone around teeth: The periodontal ligament blood vessels, the
periosteal blood vessels, and the alveolar bone blood vessels. After tooth removal,
20% of the blood supply from periodontal ligament blood vessels is discontinued. If
a flap is elevated on the buccal side, the periosteal blood supply will be discontinued
for 4 to 6 days, until new anastomoses occur. The thin cortical bone buccal plate has
no endosteal blood vessels; therefore, complete resorption of the buccal plate may
occur if no socket preservation technique is used.7 Bone grafting is frequently used
to prevent collapse and to minimize resorption of the thin buccal plate.8 However,
no comparative clinical studies have evaluated the fate and stability of the buccal
bone over time with or without bone regeneration.
Immediate Implant Placement
Immediate implant placement is defined as the placement of an implant into the
extraction socket at the time of tooth extraction. Immediate loading is defined as
the placement of full occlusal or incisal loading on a dental implant restoration. Imme-
diate provisionalization is a clinical protocol for the placement of an interim prosthesis,
either with occlusal contact with the opposing dentition (ie, immediate occlusal
loading) or without such occlusal contact (ie, immediate nonocclusal loading) at the
same clinical visit during which the implant is placed. Delayed loading refers to
applying force on an implant at some point after initial placement; a prosthesis is
attached or secured after a conventional healing period (for the maxilla, 3–4 months;
for the mandible, 2–3 months). Early loading refers applying force on an implant after
initial placement; a prosthesis is attached to the implant(s) before the end of the con-
ventional healing period.
There is variation in the descriptive terminology used in the dental literature to
describe the timing of implant placement. In 2004, Hammerle and colleagues9 pub-
lished a consensus report containing a new classification system for the timing of
implant placement. This classification is based on the structural changes that occur
after extraction on and knowledge derived from clinical observations (Table 1).
Table 1
Timing of implant placement
Time After
Classification Terminology Extraction Clinical Findings
Type 1 Immediate implant placement Immediately Fresh extraction socket
Type 2 Early implant placement 4–6 wk Healed soft tissue
Type 3 Delayed implant placement 3–4 mo Healed soft tissue and
substantial bone healing
Type 4 Late implant placement >4 mo Completely healed bone
Adapted from Hammerle CH, Chen ST, Wilson TG Jr. Consensus statements and recommended clin-
ical procedures regarding the placement of implants in extraction sockets. Int J Oral Maxillofac Im-
plants 2004;19(Suppl):26–8.
76 Al-Sabbagh & Kutkut
Lang and associates,17 the survival rate of immediate implants is 97.3% to 99%. The
effect of apical pathology on the survival of an implant immediately placed in an
extraction socket is debatable. Some studies have found that the survival rates for im-
plants placed immediately into infected sockets18 and those for implants placed in
noninfected socket or healed ridges are similar.19,20
Traditional guidelines have stressed the need for complete healing of the alveolar
bone before an implant is placed into a fresh extraction socket, a process that usu-
ally requires several months.21,22 This lengthy undisturbed healing period extends
the time of oral functional disability and substantial resorption of the alveolar ridge
may occur. Shanaman23 and Denissen and co-workers24 reported that the dimen-
sions of the alveolar ridge can be maintained after immediate implant placement,
whereas Werbitt and Goldberg25 reported that soft tissue preservation is optimal af-
ter immediate implant placement. Immediate implant placement may reduce the
number of operative interventions required and the treatment time.26 The ideal
orientation of the implant may be achieved.27 Preserving the architecture of the
hard and soft tissues at the extraction site may provide optimal restorative esthetics
(Table 2).23,28
Table 2
Advantages and disadvantages of immediate implant placement
Advantages Disadvantages
One surgical procedure Surgically demanding; complex procedure
Less treatment time Risk of marginal mucosal recession
Preservation of bone at extraction site Adjunct connective tissue graft
Reduction in cost Adjunct bone graft or guided bone regeneration
Immediate Implant Placement 77
Fig. 2. Maxillary right incisor is nonrestorable. Site is suitable for immediate implant place-
ment. (A) Adequate bone past the root apex for primary stability and no evidence of radio-
graphic infection. (B) Thick gingival biotype with good adjacent dentition. (C) Intact thick
buccal plate of the extraction socket.
the interlock between bone and titanium and ultimately resulting in a loss of primary
stability. It is critical that there are no occlusal implant overloads during the early heal-
ing stage. Primary stability is important during the first days after implant installation.
The first weeks are a crucial period because primary stability can decrease to critical
levels before secondary stability develops. Any micromotion of more than 150 mm
causes fibrous encapsulation of the implant. Therefore, patients should be compliant
and should avoid high masticatory forces by eating only soft foods for at least for
6 weeks postoperatively.30,31
Fig. 3. Maxillary right central incisor has periodontal abscess. Site is not suitable for imme-
diate implant placement. (A) Clinical sign of active infection (pus). (B) Significant loss of the
extraction socket walls.
78 Al-Sabbagh & Kutkut
Box 1
Criteria for immediate implant placement
Low-risk patient
Low esthetic expectations
Adequate quality and quantity of soft tissue
Adequate quality and quantity of socket bone
Absence of diffuse infection
Healthy condition of adjacent teeth and supporting structures
Primary stability
Fig. 4. Horizontal defect dimension (jumping distance). (A) Fresh extraction socket with
intact walls. (B) Longest distance in a perpendicular direction from the implant surface to
the socket wall (arrows). (C) The jumping distance was grafted with bone particulate.
region, and reducing the need for jumping distance augmentation.41–43 McAllister and
associates41 reported safe and effective application after using variable thread
tapered implants. Although the difference was not significant, Sanz and colleagues43
reported less vertical and horizontal space using tapered implants than of cylindrical
implants after immediate implant placements. However, Lang and colleagues40 found
in a clinical trial that both cylindrical and tapered implants have shown similar short-
term outcomes with regard to wound healing and primary stability. Bone augmenta-
tion at the time of implant placement was required for both designs in transmucosal
placement approach.
Rough Surface
Increased surface roughness of an implant can help to improve primary stability.44 In
a clinical study involving 1925 immediate implants placed from 1988 to 2004,
Wagenberg and Froum45 reported a higher success rate for immediate implants
with rough surface than for immediate implants with machined surfaces.
Implant Design
The effect of the design of the implant collar or neck placed immediately after the tooth
extraction on the peri-implant soft and hard tissues has been explored in several
experimental studies.46–48 They reported that implants with roughened and micro-
threaded neck would cause less resorption of the crestal bone than implants with
roughened and not microthreaded neck. These studies are in agreement with 1 clinical
study involving delayed implant placement, which showed less marginal bone resorp-
tion around roughened and microthreaded neck than of machined neck.49 The use of
tapered platform-switched internal connection implants at the implant shoulder is
80 Al-Sabbagh & Kutkut
recommended for immediate implant placement, because these implants can allow
rapid rehabilitation with no adverse impact on implant survival.
SURGICAL TECHNIQUES
Implant placement in a fresh extraction socket was first introduced by Schulte and as-
sociates.56 Since then, the immediate replacement of a missing tooth has been consid-
ered a time-effective approach.26,57 The buccal plate is usually more vulnerable to
resorption after extraction.2 Using an atraumatic extraction technique that results in
minimal trauma to hard and soft tissues is a key factor in immediate or delayed implant
placement.58 Generally, surgical elevation of a mucoperiosteal flap and tooth
sectioning are used when the clinician believes that excessive force would be neces-
sary to remove the tooth, when a substantial amount of the crown is missing or covered
by tissue, or when access to the root of a tooth is difficult, such as when a fragile crown
is present.59 Flapless and flap techniques for immediate implant placement have favor-
able hard tissue and soft tissue outcomes.60 Flapless implants are feasible and have
been shown to reduce postoperative discomfort for correctly selected patients.61,62
The concept of atraumatic extraction includes managing the soft and hard tissues
around the tooth. Atraumatic extraction may include placing an intrasulcular incision
360 around the tooth to cut the connective tissue fibers above the bone and to detach
the connective tissue fibers from the cementum.58 The interproximal contact surfaces
should be trimmed to facilitate the application of the periotome and the elevator and to
clear the path of tooth removal.58 The periotome is usually pushed into to the peri-
odontal ligament space with light mallet tapping along the crestal third of the inter-
proximal bone. This process should take 10 to 30 seconds, after which a forceps is
used with controlled force to luxate the tooth before extraction (Fig. 5).58 For
Fig. 5. Atraumatic extraction with integrity of alveolus maintained. (A) Periotome is pushed
into the periodontal ligament along the crestal third of the interproximal bone to luxate the
maxillary right lateral tooth. (B) Titan forceps is used to atraumatically extract the tooth. (C)
The tooth was extracted with the preservation of soft and bone tissues of the extraction
socket.
82 Al-Sabbagh & Kutkut
multirooted teeth, root sectioning and separation are advisable (Fig. 6).63 A drilling
depth of 4 to 6 mm is required for sectioning the upper first and second molars,
whereas a drilling depth of 3 to 4 mm is required for the lower first and second molars.
A long fine bur is recommended for sectioning the roots.64 All granulation tissue should
be removed from the extraction socket.
The osteotomy for an immediate placement of anterior implant could be initiated
more palatally (Fig. 7), whereas for premolars and molars the osteotomy could be
initiated toward the center of the socket. A Lindemann bur (Komet Dental, Lemgo,
Germany) or a small (number 2) round bur is recommended for creating the initial
hole in the extraction socket before the implant twist drills are used.
For the posterior region, the crown of the molar should be cut off horizontally. The
roots should be carefully separated, and the inter-radicular bone within the socket
should be maintained for use in osteotomy preparation. The Piezo procedure may
be used to assist in removal of the ankylosed roots. A round bur should be positioned
off center toward the lingual side of the inter-radicular septum. This positioning allows
for preparation of the implant placement site in a centrally located position but away
from the buccal bone plate. To compensate for natural bone resorption after tooth
extraction, the implant site must allow the implant to be seated 1 to 2 mm below
the margin of the intact buccal bony wall. If the residual jumping distance is more
than 2 mm wide, a bone graft should be used.65–68
Special attention should be paid to the restoratively driven 3-dimensional posi-
tioning of the implants.69 Immediate implant placement should always follow the
rule of restorative-driven 3-dimensional placement not only to provide functional
replacement of missing teeth, but also to satisfy the esthetic needs of the patient
particularly in the esthetic zone. More guidance on the proper 3-dimensional place-
ment of dental implants is provided by an article published in 2006 (Fig. 8).70
For adequate primary stability, immediate implants should be placed few millime-
ters beyond the socket39 or 3 to 5 mm past the apex.63 The diameter of the implant
Fig. 7. The initial hole for the preparation of implant osteotomy should be placed on the
conjunction of the middle and apical thirds of the lingual wall of the extraction socket of
maxillary anterior teeth.
should exceed the root diameter, and primary stability must be obtained with a pristine
apical and lateral socket wall.63
If the clinician believes that the existing socket precludes the attainment of primary
stability for an appropriately sized implant in an ideal restorative position, immediate
implant placement should be avoided, and guided bone regeneration and delayed
implant placement can be undertaken. The implant should not touch the buccal plate
of the socket wall in the maxillary anterior teeth, because such touching could cause
resorption of buccal plate and esthetic risk.71–73 The implant must be placed at least
1 mm subcrestally, especially if the buccal or lingual plates are thin,63 or 2 to 3 mm
below the gingival margin.74 The extraction and the placement of the implant should
be flapless, when possible,62 or can use a sulcular incision, 1 tooth mesial and 1 tooth
distal to the implant site, which could help to expose the buccal bone.61
Fig. 8. (A, B) Preoperative radiographic and clinical assessment of maxillary right lateral for
immediate implant placement. (C) Intraoperative assessment of apicocoronal placement of
immediate implant. (D) Intraoperative assessment of mesiodistal placement of immediate
implant. (E) Intraoperative assessment of buccolingual placement of immediate implant.
84 Al-Sabbagh & Kutkut
After immediate implant placement, the jumping distance or the horizontal gap be-
tween the implant and the buccal surface should be filled with bone fill if the gap is
larger than 2 mm.35,75 All types of bone fill are effective for closing the horizontal
gap (Tables 3 and 4).5
Provisional Options
The key elements in preserving ridge contour are protection and maintenance of the
bone graft during the healing phase of treatment, which can extend for several
months. A contoured healing abutment or provisional restoration provides these ele-
ments to the bone graft. The alternative to using a contoured healing abutment is the
fabrication of a screw-retained provisional restoration.
Screw-retained provisional restorations are more commonly fabricated of autopoly-
merizing acrylic resin in infra-occlusion than are cement-retained restorations. Excess
cement may compromise peri-implant tissues if it is not completely removed. The pro-
visional restorations should have subgingival contours that conform to support the soft
tissue emergence profile and help to protect the blood clot as well as any graft parti-
cles that may be placed.
In cases that do not involve immediate provisional restoration, a straight healing
abutment or a stock contoured healing abutment should be placed. A fixed partial
denture is more suitable than a removable partial denture in preventing any pressure
or movement at the surgical site. Moreover, the pontic can be modified to avoid con-
tact with the healing abutment.
Immediate provisional restoration can control displacement of the available soft tis-
sue around a single implant to create the desired soft tissue contour. Provisional res-
torations allow evaluation of esthetic parameters before treatment is completed and
provide comfort and psychological advantages for the patient. The cervical contour
of the temporary restoration will guide the scallop of the gingival margin and the height
of the interdental papillae.77,78
Table 3
Surgical exploration for immediate implant placement
Consideration Details
Difficulty of extraction a. Atraumatic (careful luxation, possible use of a periosteotome
for anterior teeth, consider flapless procedure)
b. Difficult
Anatomy of the socket a. Buccal cortical wall thickness
b. Buccal wall integrity: Fenestration or dehiscence
The most important aspects of an extraction site in determining its
suitability for immediate implantation are:
The number of remaining walls
The preexisting amount of attachment loss
The position and condition of the arch
This is one of the most important parts of decision making
because it determines the need for more advanced
procedures, such as GBR or CTG
Availability of bone a. Ample 4 mm: Suitable for immediate implant placement
past the apex of the b. Limited: Primary stability may not be achieved in certain sites
root
Primary stability a. Absence of axial or lateral mobility with physical resistance to
rotation
b. Place depth gauge and compare depth with proposed length
and width of implant
c. If inadequate primary stability, immediate implant placement
is not recommended
Implant positioning Restoration-driven implant positioning should be achieved in 3
dimensions for optimal esthetic treatment outcome
a. Buccolingual
b. Mesiodistal
c. Apicocoronal
d. Angulation
HDD a. HDD < 2 mm: Augmentation not required, defect will heal
spontaneously
b. HDD > 2 mm: Will not heal predictably; augmentation required
Adjunct therapy a. Intact thick buccal bone with thick gingival biotype: Immediate
implant placement, consider flapless procedure
b. Intact thick buccal bone, thin scalloped biotype: Immediate
implant placement, consider CTG
c. Intact thin buccal bone and thick scalloped biotype: Immediate
implant placement with flapless procedure and grafting of
facial jumping distance
d. Intact thin buccal bone and thin scalloped biotype: Possible
immediate implant placement in low-risk patients with flapless
procedure and grafting of facial jumping distance in addition
to staged CTG
c. Small defect in buccal bone, but implant can be placed with
stability: Possible immediate implant placement with GBR with
or without staged CTG
d. Major defect in buccal bone, implant will not be placed in
optimal position: Consider delayed implant placement
Abbreviations: CTG, connective tissue graft; GBR, guided bone regeneration; HDD, horizontal
defect dimension.
86 Al-Sabbagh & Kutkut
Table 4
Recommendations for osteotomy preparation for immediate implant placement
Table 4
(continued)
Although immediate implant placement is associated with high success rates and
survival rates, complications can occur. The most common complications are poor
3-dimensional implant positioning, inadequate band of keratinized tissue, gingival reces-
sion, unacceptable esthetics, and implant failure because of surgical trauma, contami-
nation of the surgical field, premature loading, implant design, anatomic limitations
such as quality and quantity of bone, systemic factors, and unknown factors. Implant fail-
ure can be classified as early when osseointegration is not achieved or as late when
achieved osseointegration is lost after function begins. Early implant failure is caused
by inability to regenerate intimate bone-to-implant contact, resulting in impaired wound
healing after implant placement. Clinical indications of early implant failure are bone loss,
implant mobility, pain or other symptoms during function, and biological infection.84,85
Fenestration or Dehiscence
The complications of fenestration and dehiscence have been reported to occur after
immediate implant placement.39 The most commons area for fenestration during the
immediate implant placement are the maxillary anterior and premolar sockets. The
socket apex can be more facially oriented and is frequently misleading during the initi-
ation of the osteotomy preparation. A round bur positioned off center toward the
palatal side and along the alveolar ridge angulation reduces the chance of fenestration
of facial plate of the alveolar ridge. When these complications occur, spontaneous
bone regeneration may be possible; however, in some cases, delayed implant place-
ment is advisable.86,87 For managing fenestration or dehiscence, a resorbable or non-
resorbable membrane can be used with or without bone particulate from various
sources.5,88 However, bone augmentation techniques may lead to suboptimal
bone-to-implant contact and soft tissue esthetics, especially when achieving primary
closure of the surgical site is difficult (Fig. 9).89,90
88 Al-Sabbagh & Kutkut
Fig. 9. Fenestration of the buccal plate during immediate placement of implant in a fresh
extraction socket of maxillary premolar. (A) Penetration of apex of the implant through
the buccal bony plate (arrow). (B) Primary stability is achieved and bone graft particles
were placed. (C) Collagen membrane was placed on the bone particulates.
Fig. 10. The use of osteotome with packing of bone graft material into an extraction socket
to expand the extraction socket and condense the spongy trabecular bone to increase the
primary stability.
Immediate Implant Placement 89
failure of an implant. Recession can be avoided and the long-term stability of the
mucosal tissue around the implant can be ensured by the use of adjunct soft tissue
grafting. Authors of current article recommend following the adjunct soft tissue ther-
apy guidelines described in Table 3.
Surgical Trauma
Bone is viable and is sensitive to temperature. Overheating the bone during prepara-
tion of the implant osteotomy site can lead to necrosis of the bone tissue surrounding
the dental implant. Less surgical trauma is expected when clinicians are skillful and
experienced, and the clinician’s skill is an important factor in the successful outcome
of dental implants.
Overheating the bone should be avoided by using copious irrigation and periodic
replacement of twist drills to ensure sharpness. The implant manufacturer’s guidelines
for drilling speed should be followed, and low hand pressure is warranted during high-
speed drilling in dense bone.
Infection
Strict antiseptic protocol should be followed during surgical implant placement. Pre-
medication with broad-spectrum antibiotics is recommended. Thorough debridement
of contained infection in the extraction socket and excavation of all of the soft and
granulation tissues are necessary. In cases of active diffuse infection, delayed implant
placement is recommended.
Violation of Anatomic Structure
The availability of 3 to 5 mm of bone past the apex of the root is often necessary for
primary stability and is helpful for avoiding the violation of surrounding anatomic struc-
tures. The implementation of a vertical sinus lift with an osteotome and the placement
of a wide-neck implant decrease the likelihood of introducing an immediate implant
into the maxillary sinus cavity. Obtaining cross-sectional radiographic images for
locating the maxillary sinus, the nasal cavity, the inferior alveolar canal, and the lingual
undercut (submandibular fossa) is helpful for avoiding the violation of these anatomic
structure because it ensures at least 2 mm of clearance between the implant apex and
the surrounding structures.
Implant Stability
Primary stability and success of implants are more likely when implants are supported
by cortical bone. Bicortical anchorage is associated with some complications, but it
results in good primary stability and better distribution of loading forces than moncort-
ical anchorage.
Malpositioning of Implant
Restoration-driven implant position must be correct in 3 dimensions for optimal func-
tional and esthetic outcomes. Correction of integrated malpositioned implants is diffi-
cult and limited to prosthetic correction; otherwise, removal of the implant is
warranted. Buccolingual, mesiodistal, and apicocoronal angulation of an implant
immediately placed into an extraction socket is reviewed in an article published in
2006.70
Unesthetic Outcome
Certain esthetic complications are associated with immediate implant placement. For
example, tissue alterations leading to recession of the facial mucosa and papillae are
90 Al-Sabbagh & Kutkut
SUMMARY
REFERENCES
9. Hammerle CH, Chen ST, Wilson TG Jr. Consensus statements and recommended
clinical procedures regarding the placement of implants in extraction sockets. Int
J Oral Maxillofac Implants 2004;19(Suppl):26–8.
10. Gelb DA. Immediate implant surgery: three-year retrospective evaluation of 50
consecutive cases. Int J Oral Maxillofac Implants 1993;8(4):388–99.
11. Lang NP, Bragger U, Hammerle CH, et al. Immediate transmucosal implants us-
ing the principle of guided tissue regeneration. I. Rationale, clinical procedures
and 30-month results. Clin Oral Implants Res 1994;5(3):154–63.
12. Bragger U, Hammerle CH, Lang NP. Immediate transmucosal implants using the
principle of guided tissue regeneration (II). A cross-sectional study comparing
the clinical outcome 1 year after immediate to standard implant placement.
Clin Oral Implants Res 1996;7(3):268–76.
13. Rosenquist B, Grenthe B. Immediate placement of implants into extraction
sockets: implant survival. Int J Oral Maxillofac Implants 1996;11(2):205–9.
14. Schwartz-Arad D, Grossman Y, Chaushu G. The clinical effectiveness of implants
placed immediately into fresh extraction sites of molar teeth. J Periodontol 2000;
71(5):839–44.
15. Gomez-Roman G, Kruppenbacher M, Weber H, et al. Immediate postextraction
implant placement with root-analog stepped implants: surgical procedure and
statistical outcome after 6 years. Int J Oral Maxillofac Implants 2001;16(4):
503–13.
16. Goldstein M, Boyan BD, Schwartz Z. The palatal advanced flap: a pedicle flap for
primary coverage of immediately placed implants. Clin Oral Implants Res 2002;
13(6):644–50.
17. Lang NP, Pun L, Lau KY, et al. A systematic review on survival and success rates
of implants placed immediately into fresh extraction sockets after at least 1 year.
Clin Oral Implants Res 2012;23(Suppl 5):39–66.
18. Waasdorp JA, Evian CI, Mandracchia M. Immediate placement of implants into
infected sites: a systematic review of the literature. J Periodontol 2010;81(6):
801–8.
19. Crespi R, Cappare P, Gherlone E. Fresh-socket implants in periapical infected
sites in humans. J Periodontol 2010;81(3):378–83.
20. Crespi R, Cappare P, Gherlone E. Immediate loading of dental implants placed in
periodontally infected and non-infected sites: a 4-year follow-up clinical study.
J Periodontol 2010;81(8):1140–6.
21. Adell R, Lekholm U, Rockler B, et al. A 15-year study of osseointegrated implants
in the treatment of the edentulous jaw. Int J Oral Surg 1981;10(6):387–416.
22. Albrektsson T, Zarb G, Worthington P, et al. The long-term efficacy of currently
used dental implants: a review and proposed criteria of success. Int J Oral Max-
illofac Implants 1986;1(1):11–25.
23. Shanaman RH. The use of guided tissue regeneration to facilitate ideal pros-
thetic placement of implants. Int J Periodontics Restorative Dent 1992;12(4):
256–65.
24. Denissen HW, Kalk W, Veldhuis HA, et al. Anatomic consideration for preventive
implantation. Int J Oral Maxillofac Implants 1993;8(2):191–6.
25. Werbitt MJ, Goldberg PV. The immediate implant: bone preservation and bone
regeneration. Int J Periodontics Restorative Dent 1992;12(3):206–17.
26. Lazzara RJ. Immediate implant placement into extraction sites: surgical and
restorative advantages. Int J Periodontics Restorative Dent 1989;9(5):332–43.
27. Schultz AJ. Guided tissue regeneration (GTR) of nonsubmerged implants in imme-
diate extraction sites. Pract Periodontics Aesthet Dent 1993;5(2):59–65 [quiz: 66].
92 Al-Sabbagh & Kutkut
28. Kalk W, Denissen HW, Kayser AF. Preventive goals in oral implantology. Int Dent J
1993;43(5):483–91.
29. Schwartz-Arad D, Chaushu G. Placement of implants into fresh extraction sites: 4
to 7 years retrospective evaluation of 95 immediate implants. J Periodontol 1997;
68(11):1110–6.
30. Wohrle PS. Single-tooth replacement in the aesthetic zone with immediate provi-
sionalization: fourteen consecutive case reports. Pract Periodontics Aesthet Dent
1998;10(9):1107–14 [quiz: 1116].
31. Gapski R, Wang HL, Mascarenhas P, et al. Critical review of immediate implant
loading. Clin Oral Implants Res 2003;14(5):515–27.
32. Wilson TG Jr, Schenk R, Buser D, et al. Implants placed in immediate extraction
sites: a report of histologic and histometric analyses of human biopsies. Int J Oral
Maxillofac Implants 1998;13(3):333–41.
33. Botticelli D, Berglundh T, Buser D, et al. The jumping distance revisited: an exper-
imental study in the dog. Clin Oral Implants Res 2003;14(1):35–42.
34. Wilson TG Jr. Guided tissue regeneration around dental implants in immediate
and recent extraction sites: initial observations. Int J Periodontics Restorative
Dent 1992;12(3):185–93.
35. Paolantonio M, Dolci M, Scarano A, et al. Immediate implantation in fresh extraction
sockets. A controlled clinical and histological study in man. J Periodontol 2001;
72(11):1560–71.
36. Botticelli D, Berglundh T, Lindhe J. Hard-tissue alterations following immediate
implant placement in extraction sites. J Clin Periodontol 2004;31(10):820–8.
37. Tarnow DP, Chu SJ, Salama MA, et al. Flapless postextraction socket implant
placement in the esthetic zone: part 1. The effect of bone grafting and/or provi-
sional restoration on facialpalatal ridge dimensional change-a retrospective
cohort study. Int J Periodontics Restorative Dent 2014;34(3):323–31.
38. Brånemark PI, Adell R, Breine U, et al. Intra-osseous anchorage of dental
prostheses. I. Experimental studies. Scand J Plast Reconstr Surg 1969;
3(2):81–100.
39. Schropp L, Isidor F. Timing of implant placement relative to tooth extraction.
J Oral Rehabil 2008;35(Suppl 1):33–43.
40. Lang NP, Tonetti MS, Suvan JE, et al. Immediate implant placement with trans-
mucosal healing in areas of aesthetic priority. A multicentre randomized-
controlled clinical trial I. Surgical outcomes. Clin Oral Implants Res 2007;
18(2):188–96.
41. McAllister BS, Cherry JE, Kolinski ML, et al. Two-year evaluation of a variable-
thread tapered implant in extraction sites with immediate temporization: a multi-
center clinical trial. Int J Oral Maxillofac Implants 2012;27(3):611–8.
42. Kolinski ML, Cherry JE, McAllister BS, et al. Evaluation of a variable-thread
tapered implant in extraction sites with immediate temporization: a 3-year multi-
center clinical study. J Periodontol 2014;85(3):386–94.
43. Sanz M, Cecchinato D, Ferrus J, et al. A prospective, randomized-controlled clin-
ical trial to evaluate bone preservation using implants with different geometry
placed into extraction sockets in the maxilla. Clin Oral Implants Res 2010;
21(1):13–21.
44. Simon Z, Watson PA. Biomimetic dental implants–new ways to enhance osseoin-
tegration. J Can Dent Assoc 2002;68(5):286–8.
45. Wagenberg B, Froum SJ. A retrospective study of 1925 consecutively placed im-
mediate implants from 1988 to 2004. Int J Oral Maxillofac Implants 2006;21(1):
71–80.
Immediate Implant Placement 93
46. Calvo-Guirado JL, Lopez-Lopez PJ, Mate Sanchez de Val JE, et al. Influence of
collar design on peri-implant tissue healing around immediate implants: a pilot
study in Foxhound dogs. Clin Oral Implants Res 2014. [Epub ahead of print].
47. Calvo-Guirado JL, Boquete-Castro A, Negri B, et al. Crestal bone reactions to im-
mediate implants placed at different levels in relation to crestal bone. A pilot
study in Foxhound dogs. Clin Oral Implants Res 2014;25(3):344–51.
48. Negri B, Calvo-Guirado JL, Pardo-Zamora G, et al. Peri-implant bone reactions to
immediate implants placed at different levels in relation to crestal bone. Part I: a
pilot study in dogs. Clin Oral Implants Res 2012;23(2):228–35.
49. Nickenig HJ, Wichmann M, Schlegel KA, et al. Radiographic evaluation of mar-
ginal bone levels adjacent to parallel-screw cylinder machined-neck implants
and rough-surfaced microthreaded implants using digitized panoramic radio-
graphs. Clin Oral Implants Res 2009;20(6):550–4.
50. Cannizzaro G, Leone M, Ferri V, et al. Immediate loading of single implants
inserted flapless with medium or high insertion torque: a 6-month follow-up of
a split-mouth randomised controlled trial. Eur J Oral Implantol 2012;5(4):
333–42.
51. Ottoni JM, Oliveira ZF, Mansini R, et al. Correlation between placement torque
and survival of single-tooth implants. Int J Oral Maxillofac Implants 2005;20(5):
769–76.
52. Atieh MA, Alsabeeha NH, Payne AG, et al. Insertion torque of immediate wide-
diameter implants: a finite element analysis. Quintessence Int 2012;43(9):
e115–26.
53. Ericsson I, Nilson H, Lindh T, et al. Immediate functional loading of Branemark
single tooth implants. An 18 months’ clinical pilot follow-up study. Clin Oral Im-
plants Res 2000;11(1):26–33.
54. Sanz-Sanchez I, Sanz-Martin I, Figuero E, et al. Clinical efficacy of immediate
implant loading protocols compared to conventional loading depending on the
type of the restoration: a systematic review. Clin Oral Implants Res 2014.
[Epub ahead of print].
55. Kinaia BM, Shah M, Neely AL, et al. Crestal bone level changes around immediately
placed implants: a systematic review and meta-analyses with at least 12 months
follow up after functional loading. J Periodontol 2014. [Epub ahead of print].
56. Schulte W, Kleineikenscheidt H, Lindner K, et al. The Tubingen immediate implant
in clinical studies. Dtsch Zahnarztl Z 1978;33(5):348–59 [in German].
57. Parel SM, Triplett RG. Immediate fixture placement: a treatment planning alterna-
tive. Int J Oral Maxillofac Implants 1990;5(4):337–45.
58. Misch CE, Suzuki JB. Tooth extraction, socket grafting, and barrier membrane
bone regeneration. In: Misch CE, editor. Contemporary implant dentistry. 3rd edi-
tion. St Louis (MO): Mosby; 2008. p. 870–6.
59. Hupp JR, Ellis E, Tucker MR, editors. Contemporary oral and maxillofacial sur-
gery. 5th edition. St Louis (MO): Mosby; 2008.
60. Esposito M, Grusovin MG, Pdyzos IP, et al. Interventions for replacing missing
teeth: different times for loading dental implants. Cochrane Database Syst Rev
2009;(1):CD003878.
61. Capelli M, Testori T, Galli F, et al. Implant-buccal plate distance as diagnostic
parameter: a prospective cohort study on implant placement in fresh extraction
sockets. J Periodontol 2013;84(12):1768–74.
62. Guarnieri R, Ceccherini A, Grande M. Single-tooth replacement in the anterior
maxilla by means of immediate implantation and early loading: clinical and
aesthetic results at 5 years. Clin Implant Dent Relat Res 2013. [Epub ahead of print].
94 Al-Sabbagh & Kutkut
81. Romanos GE, Toh CG, Siar CH, et al. Histologic and histomorphometric evalua-
tion of peri-implant bone subjected to immediate loading: an experimental study
with Macaca fascicularis. Int J Oral Maxillofac Implants 2002;17(1):44–51.
82. Rocci A, Martignoni M, Burgos PM, et al. Histology of retrieved immediately and
early loaded oxidized implants: light microscopic observations after 5 to 9
months of loading in the posterior mandible. Clin Implant Dent Relat Res 2003;
5(Suppl 1):88–98.
83. Tarnow DP, Emtiaz S, Classi A. Immediate loading of threaded implants at stage 1
surgery in edentulous arches: ten consecutive case reports with 1- to 5-year data.
Int J Oral Maxillofac Implants 1997;12(3):319–24.
84. Badell CL, Palaiologou A, Vastardis SA. Early dental implant failure after immedi-
ate placement. J West Soc Periodontol Periodontal Abstr 2009;57(3):67–77.
85. Schwartz-Arad D, Laviv A, Levin L. Survival of immediately provisionalized dental
implants placed immediately into fresh extraction sockets. J Periodontol 2007;
78(2):219–23.
86. Schropp L, Kostopoulos L, Wenzel A. Bone healing following immediate versus
delayed placement of titanium implants into extraction sockets: a prospective
clinical study. Int J Oral Maxillofac Implants 2003;18(2):189–99.
87. Dahlin C, Andersson L, Linde A. Bone augmentation at fenestrated implants by
an osteopromotive membrane technique. A controlled clinical study. Clin Oral Im-
plants Res 1991;2(4):159–65.
88. Schwartz-Arad D, Chaushu G. The ways and wherefores of immediate placement
of implants into fresh extraction sites: a literature review. J Periodontol 1997;
68(10):915–23.
89. Gher ME, Quintero G, Assad D, et al. Bone grafting and guided bone regenera-
tion for immediate dental implants in humans. J Periodontol 1994;65(9):881–91.
90. Augthun M, Yildirim M, Spiekermann H, et al. Healing of bone defects in combi-
nation with immediate implants using the membrane technique. Int J Oral Maxil-
lofac Implants 1995;10(4):421–8.
91. Chen ST, Buser D. Clinical and esthetic outcomes of implants placed in postex-
traction sites. Int J Oral Maxillofac Implants 2009;24(Suppl):186–217.
92. Martin W, Lewis E, Nicol A. Local risk factors for implant therapy. Int J Oral Max-
illofac Implants 2009;24(Suppl):28–38.