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    Sodium Fluoride BP

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    Jai Murugesh
    Sodium fluoride is used in prevention of dental caries. It is a white or colorless powder or crystals that is soluble in water and practically insoluble in ethanol. Tests are performed to identify sodium fluoride and check for impurities such as chlorides, fluorosilicates, and sulfates. The content must be between 98.5-100.5% and loss on drying must be a maximum of 0.5%.

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    Sodium Fluoride BP

    Uploaded by

    Jai Murugesh
    9 views3 pages
    Sodium fluoride is used in prevention of dental caries. It is a white or colorless powder or crystals that is soluble in water and practically insoluble in ethanol. Tests are performed to identify sodium fluoride and check for impurities such as chlorides, fluorosilicates, and sulfates. The content must be between 98.5-100.5% and loss on drying must be a maximum of 0.5%.

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    Sodium Fluoride BP API

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    Sodium fluoride is used in prevention of dental caries. It is a white or colorless powder or crystals that is soluble in water and practically insoluble in ethanol. Tests are performed to identify sodium fluoride and check for impurities such as chlorides, fluorosilicates, and sulfates. The content must be between 98.5-100.5% and loss on drying must be a maximum of 0.5%.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    9 views3 pages

    Sodium Fluoride BP

    Uploaded by

    Jai Murugesh
    Sodium fluoride is used in prevention of dental caries. It is a white or colorless powder or crystals that is soluble in water and practically insoluble in ethanol. Tests are performed to identify sodium fluoride and check for impurities such as chlorides, fluorosilicates, and sulfates. The content must be between 98.5-100.5% and loss on drying must be a maximum of 0.5%.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 3

    Sodium Fluoride

    General Notices
    (Ph. Eur. monograph 0514)
    NaF 41.99 7681-49-4
    Action and use
    Used in prevention of dental caries.
    Preparations
    Sodium Fluoride Mouthwash
    Sodium Fluoride Oral Drops
    Sodium Fluoride Oral Solution
    Sodium Fluoride Tablets

    Ph Eur
    DEFINITION
    Content
    98.5 per cent to 100.5 per cent (dried substance).
    CHARACTERS
    Appearance
    White or almost white powder or colourless crystals.
    Solubility
    Soluble in water, practically insoluble in ethanol (96 per cent).
    IDENTIFICATION
    A. To 2 mL of solution S (see Tests) add 0.5 mL of calcium chloride solution R. A
    gelatinous white precipitate is formed that dissolves on adding 5 mL of ferric
    chloride solution R1.
    B. To about 4 mg add a mixture of 0.1 mL of alizarin S solution R and 0.1 mL
    of zirconyl nitrate solution Rand mix. The colour changes from red to yellow.
    C. Solution S gives reaction (a) of sodium (2.3.1).
    TESTS
    Solution S
    Dissolve 2.5 g in carbon dioxide-free water R without heating and dilute to 100 mL
    with the same solvent.
    Appearance of solution
    Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
    Acidity or alkalinity
    Dissolve 2.5 g of potassium nitrate R in 40 mL of solution S and dilute to 50 mL
    with carbon dioxide-free water R. Cool to 0 °C and add 0.2 mL of phenolphthalein
    solution R. If the solution is colourless, not more than 1.0 mL of 0.1 M sodium
    hydroxide is required to produce a red colour that persists for at least 15 s. If the
    solution is red, not more than 0.25 mL of 0.1 M hydrochloric acid is required to
    change the colour of the indicator.
    Chlorides (2.4.4)
    Maximum 200 ppm.
    Dilute 10 mL of solution S to 15 mL with water R.
    Fluorosilicates
    Heat to boiling the neutralised solution obtained in the test for acidity or alkalinity
    and titrate whilst hot. Not more than 0.75 mL of 0.1 M sodium hydroxide is
    required to change the colour of the indicator to red.
    Sulfates (2.4.13)
    Maximum 200 ppm.
    Dissolve 0.25 g in 10 mL of a 223 g/L solution of aluminium nitrate R. Add 5 mL
    of distilled water R and 0.6 mL of hydrochloric acid R1. Prepare the standard by
    mixing 0.6 mL of hydrochloric acid R1, 5 mL ofsulfate standard solution (10 ppm
    SO4) R and 10 mL of a 223 g/L solution of aluminium nitrate R.
    Loss on drying (2.2.32)
    Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 130 °C for
    3 h.
    ASSAY
    Dissolve 0.100 g in water R and dilute to 60 mL with the same solvent. Titrate
    with 0.1 M lanthanum nitrate, determining the end-point potentiometrically
    (2.2.20) using a fluoride-selective indicator electrode and a silver-silver chloride
    reference electrode.
    1 mL of 0.1 M lanthanum nitrate is equivalent to 12.60 mg of NaF.

    Ph Eur

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