TRANSCRIPTION

OF RNA
RNA polymerase II
transcribes
- polyadenylation
signal sequence ↳

(MRNA termination sequence)

Termination of
on DNA
3) Transcription
leads to production of
polyadenylation signal (AAUFA)
in
pre-mRNA
A
&
O

-
A

>

ea
pre-mRNA
to Exet T
Intron
Exon

MRNA inten
Exen

noncodinrgo I

e
get
~
↳Sing =
o
intron

Modification of
pre-MRNA

1) RNA alteration via : r

Addition of 2) Initiation of
9 : spliceosome Termination
d o
-

to
5/ 3' This induces
cap poly- A tail
promoter becomes recognition unwinding
the double helix
of
point for binding of DNA polymerase II
2) RNA ① of DNA
splicing
removal of
non-coding segment
(introns ( MRNA

E ③ RNA polymerase adds

free RNA nucleotides
D
in the 5'to3

· direction
-

↑
2) Elongation of Termination
·

continuation of addition of RNA

-
· ·

nucleotides to 3'end
I of growing
) RNA
polymer
·
elongates in
1 5'to 3 direction

-· DNA double helix reforms f

new RNA molecules
peels away
from DNA template