Report
Report
Report
DEPARTMENT OF IMMUNOLOGY
Comment:
1. TSH is a labile hormone & is secreted in a pulsatile manner throughout the day and is subject to several endogenous & exogenous influences.It has to be noted
that oscillation in TSH occurs throughout the day leading to within day variations of TSH measurements.
2. Significant variations in TSH can occur with circadian rhythm, hormonal status, stress, sleep deprivation, medication & circulating antibodies.
3. TSH is elevated in primary hypothyroidism and will be low in primary hyperthyroidism. Elevated or low TSH in the context of normal free thyroxine is often
referred to as sub-clinical hypo- or hyperthyroidism respectively. Nocturnal increase in TSH may be lost in critical illness or after surgery. In the first trimester of
pregnancy, TSH concentrations decline as hCG stimulates maternal thyroid gland to produce thyroid hormone.
4. Transient increase in TSH levels or abnormal TSH levels can be seen in various nonthyroidal diseases. Simultaneous measurement of TSH with free T4 is useful
in evaluating the differential diagnosis.
5. It is important to confirm any TSH abnormality in a fresh specimen drawn after ~ 3 weeks before assigning a diagnosis as the cause of an isolated TSH
abnormality.
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SIN No:IM06961822