05 Basic Pulse Sequences
05 Basic Pulse Sequences
§ Spin Echo
§ Magnetization Preparation Pulses
§ Turbo Spin Echo
§ 3D Volume
§ Gradient Echo
MR § Scan time
FID Spin echo FID = TR * NPE * NAV * NCONC
TE PE = Phase-Encoding
TR AV = Average
Conc = Concatenation
t
TE
TR 256th line
t
TE
TR 256th line
2nd slice
3rd slice
4th slice
t
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Simple Spin Echo Sequence – Example
Measurement parameters:
§ TR: 500 ms; TE: 15 ms
§ Contrast: T1-weighted
§ Field strength: 1.5 T
§ Slice thickness: 5 mm, FoV: 230 mm x 230 mm
§ 256 phase-encoding steps, 256 readout data points
→ Fat: bright
→ Grey matter darker than white matter
→ CSF: dark
Measurement parameters:
§ TR: 2850 ms
§ TE: 11 ms and 95 ms
§ Contrast: PD- and T2-
weighted
§ Field strength: 1.5 T
§ Slice thickness: 5 mm
§ FoV: 230 mm x 230 mm
§ Matrix: 256 x 320
Double Echo I: TE: 11 ms Double Echo II: TE: 95 ms
PD-weighted T2-weighted
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Turbo Spin Echo (TSE)
90° 180° 180° 180° 180° 180° 180° 180° § Multiple 180°refocusing RF-
pulses
Segmentation of k-space
T2
PE
TEeff
* = influence of PE gradients
Segmentation of k-space
T2
Echo 1
Echo 2
*
Echo 3
FID Echo 1 Echo 2 Echo 3 Echo 4 Echo 5 Echo 6 Echo 7 Echo 4
Echo 5
PE Echo 6
Echo 7
TEeff
* = influence of PE gradients
Measurement parameters:
§ TR: 2800 ms
§ TE1: 14 ms (PD-contrast)
§ TE2: 116 ms (T2-contrast)
§ Field strength: 1.5 T
§ Slice thickness: 3 mm
§ FoV: 280 mm x 258 mm
§ Matrix: 320 x 320
§ Turbofactor = 5 (i.e. for each contrast, total
number of echoes (= Echo Train) =10)
2800/14 – PD-contrast 2800/116 – T2-contrast
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Turbo Spin Echo (TSE) – Summary
STRENGTHS
§ Speed:
Scan Time =
TR * NAV * NCONC * NPE / TF
WEAKNESSES
§ Relation between TE / TF / bandwidth is difficult
§ Longer slice loops – more time per slice
§ Because of the effective TE the contrast is
“impure”
2800/14 – PD-contrast 2800/116 – T2-contrast
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Turbo Spin Echo (TSE) – RESTORE
§ Residual transverse
90o 180o 180o 180o 180o 180o 180o 180o 180° 90° magnetization after
data collection is
converted into
longitudinal
90° restoring pulse magnetization
T2water
T2tissue § That means, using a
RESTORE pulse will
increase the T2
contrast even if
relatively short
repetition times are
used
§ Residual transverse
magnetization after
data collection is
converted into
longitudinal
magnetization
§ That means, using a
RESTORE pulse will
increase the T2
contrast even if
relatively short
repetition times are
used
*tse2d1_29 *tseR2d1_29 with RESTORE
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Turbo Spin Echo (TSE) – Compensate T2 decay
SI
1 2 3 4 5 6 7 ky
1. average 2. average
Segment 1
Segment 2
Segment 3
Segment 4
Segment 5
Segment 6
Segment 7
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Turbo Spin Echo (TSE) – Compensate T2 decay
SI
1 2 3 4 5 6 7 ky
1. average 2. average
Segment 1 Segment 1
Segment 2 Segment 2
Segment 3 Segment 3
Segment 4 Segment 4
Segment 5 Segment 5
Segment 6 Segment 6
Segment 7 Segment 7
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Turbo Spin Echo (TSE) – Reduce Motion Sensitivity
RF
GS
GF
GP
RF
GS
GF
GP
RF
GS
GF
GP
RF
GS
GF
GP
§ SE with magnetization
preparation pulse,
here: 180°
§ The time between 180°
and 90° is the Inversion
Time TI
§ Application: e.g. for
significant T1-contrast,
tissue suppression
§ Addition to TSE produces
TIR(M) = Turbo Inversion
Recovery (Magnitude)
TI/TR/TE = 170/3000/39
§ IR Magnitude with
medium TI
of ~ 860 ms:
§ Increased
T1 – Contrast
§ Inversion Recovery
Magnitude with long TI of
~2000 ms
§ for suppression of CSF
(Fluid Attenuated
Inversion Recovery,
FLAIR)
§ Result: T2 – Contrast
with dark CSF
TI/TR/TE = 2500/9000/108
90° 90°
RF § No 180°refocusing pulse
GS
§ Rephasing of echo only through
gradient reversal
GR
§ TE controls T2*- rather than T2-
weighting
GP § The flip angle is an important
contrast variable
MR
FID Gradient Echo FID
TE
TR
90° 90°
RF § No 180°refocusing pulse
GS
§ Rephasing of echo only through
jS gradient reversal
GR
§ TE controls T2*- rather than T2-
jR
weighting
GP § The flip angle is an important
jP contrast variable
MR
FID Gradient Echo FID
TE
TR
RF spoiling: + , +2 , + 3 ,…
, 1 , 2 RF spoiling:
RF § Due to very short TR, residual
transverse magnetization might be still
GS present before the next RF pulse
§ Spoiling is the method by which
GR residual transverse magnetization is
destroyed prior to the application of
the next RF pulse, instead of waiting
GP for this magnetization to decay away
§ RF spoiling involves applying a phase
MR offset to each successive RF
FID Gradient Echo FID excitation pulse preventing any build
up towards a steady state
TE
TR § Only with RF spoiling pure T1 or T2*
contrast possible!
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FLASH 2D
RF spoiling: + , +2 , + 3 ,…
, 1 , 2 RF spoiling:
RF § Due to very short TR, residual
transverse magnetization might be still
GS present before the next RF pulse
§ Spoiling is the method by which
GR residual transverse magnetization is
destroyed prior to the application of
the next RF pulse, instead of waiting
GP for this magnetization to decay away
§ RF spoiling involves applying a phase
MR offset to each successive RF
FID Gradient Echo FID excitation pulse preventing any build
up towards a steady state
TE
TR § Only with RF spoiling pure T1 or T2*
contrast possible!
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Please note: The only released document for end-customer training is the operator manual.
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FLASH 2D – Images
FLASH 2D, T1- Contrast. TR/TE = 100/4.8 ms, FLASH 2D, T1- Contrast with Fatsat. TR/TE = 100/3.0 ms,
FL=70, SL 6.0 mm, FOV 263x350 mm, MA: 192 x 320, FL=70, SL 6.0 mm, FOV 263x350 mm, MA: 326 x 512 interpolated
20 Slices in 2* 19.10s. 20 Slices in 3* 16.20s.
TR=716 ms, TE=19.9 ms, Flip angle = 20°.. Because of the long TR and the long TE in combination
with the low flip angle, the images are T2*- weighted. Arrows indicate susceptibility artifacts.
Multiplanar
Reconstructions
(MPR)
, 1 , 2
RF
GS
GR
GP
MR
FID Gradient Echo FID
TE
TR
, 1 , 2
RF
GS
GR
GP
MR
FID Gradient Echo FID
TE
TR
k-space FLASH 3D
kz
ky
kz kz
Zero-filling
ky ky
Zero-filling
kz kz kz
Zero-filling Zero-filling
Zero-filling
ky ky ky
Zero-filling Zero-filling
kz kz kz
Zero-filling Zero-filling
Zero-filling
ky ky ky
Zero-filling Zero-filling
Filling these data lines with zeros improves the image appearance:
Gp
Gs § Equivalent to an interpolation, i.e. voxel-shifted images are
calculated
§ The zero filling approach improves the partial volume effect
GR § it does not improve spatial or volume resolution
§ it does reduce artifacts caused by the shape and size of pixels
in the image
Zero-filling VIBE is used for dynamic liver, pancreas, pelvis, thorax, orbita
imaging and MR colonoscopy.
Slab selective:
§ usually in 3D Imaging, slab selection is performed in slice
Slab-selective encoding direction (i.e. through plane)
§ That means in coronal imaging, the whole volume in “head
– feet” and “left – right” direction seen by the coil is excited
§ Requires large FOV and/or phase oversampling to avoid
wrap-around from the arms
Slab selective:
§ usually in 3D Imaging, slab selection is performed in slice
Slab-selective encoding direction (i.e. through plane)
§ That means in coronal imaging, the whole volume in “head
– feet” and “left – right” direction seen by the coil is excited
§ Requires large FOV and/or phase oversampling to avoid
wrap-around from the arms
Slab selective PE:
§ Means excitation is performed in phase encoding
direction
§ Allows smaller FOV in phase encoding direction (i.e. less
Slab-selective PE
phase encoding steps!)
§ Needs full coverage through-plane to avoid wrap-around
in slice direction
3.4 ppm f
(chemical shift)
GR
object:
water
fat
fat and water superimposed
no signal
Image:
GR
object:
water read
fat out
fat and water superimposed
no signal
Image:
Readout direction
Spinecho, T1-Contrast
1.5T 3.0T
§ Due to the doubled field
strength also the
chemical shift is doubled
at 3T compared to 1.5T
1.5T 3.0T
§ Due to the doubled field
strength also the
chemical shift is doubled
at 3T compared to 1.5T
1.5T 3.0T
§ Due to the doubled field
strength also the
chemical shift is doubled
at 3T compared to 1.5T
§ Doubling the readout
bandwidth will
counteract the increased
doubled chemical shift
§ However, due to the
higher bandwidth, the
SNR is reduced
90° 180°
RF
GS
GR
GP
MR
Example:
90° 180°
EPI_SE with Partial Fourier 6/8
RF
GS
GR
GP
MR
Example:
90° 180°
EPI_SE with Partial Fourier 6/8
RF
GS
GR
GP
MR
Example:
90° 180°
EPI_SE with Partial Fourier 6/8
RF
GS 1
1
GR
Preparation
GP
MR
Example:
90° 180° 2
EPI_SE with Partial Fourier 6/8
RF
GS 1
1
GR
Preparation
GP
MR
2
Example:
90° 180° 2
EPI_SE with Partial Fourier 6/8
RF
3 4
GS 1
1
GR
Preparation
GP
4
MR
2 3
Example:
90° 180°
EPI_SE with Partial Fourier 6/8
RF
GS
GR
GP
MR
Example:
90° 180°
EPI_SE with Partial Fourier 6/8
RF
GS
GR
GP
MR
echo spacing
Example:
90°
EPI_FID (→ BOLD1, DSC2)
RF
GS
GR
GP
MR
Example:
90°
EPI_FID (→ BOLD1, DSC2)
RF
GS
GR
GP
MR
Example:
90° 180°
EPI_SE with Partial Fourier 6/8
RF
GS
GR
GP
MR
Example:
90° 180°
EPI_SE with Partial Fourier 6/8
RF
GS
GR
GP
MR
Diffusion Encoding
Gradients
Example:
90° 180°
EPI_SE with Partial Fourier 6/8
RF
GS
GR
GP
MR
Diffusion Encoding
Gradients
RESOLVE
90° 180° 180°
e.g. with 5 readout segments
RF
GS
GR
GP
MR
GS
GR
GP
MR
GS
GR
GP
MR
GS
GP
MR
GS
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