GUASA MT 38 ACTIVITY 8 Hepatitis UPDATED
GUASA MT 38 ACTIVITY 8 Hepatitis UPDATED
GUASA MT 38 ACTIVITY 8 Hepatitis UPDATED
HBV ANTIBODIES
1. Antibodies to Hepatitis B Core Antigen (Anti-HBc)
2. Antibodies to Hepatitis B-Related Antigen (Anti-HBe)
3. Antibodies to Hepatitis B Surface Antigen (Anti-HBs)
VIRAL HEPATITIS SEROLOGY
Hepatitis B
HBV ANTIGENS
Hepatitis B Surface Antigen (HBsAg) – Australia antigen
o Earliest marker of infection
o Indicates active infection
Hepatitis B-Related Antigen (HBeAg)
o Present during active replication
o Indicates high degree of infectivity
Hepatitis B Core Antigen (HBcAg)
o Not detectable in serum
VIRAL HEPATITIS SEROLOGY
Hepatitis B
Genomic DNA
(double- HBV ANTIGENS
stranded with
partial single
strand)
Hepatitis Envelope
B surface
antigen
(HBsAg)
Nucleocapsid
(viral capsid)
Spherical
Envelope lipid
(from host cell)
Dane particle
(complete virion)
VIRAL HEPATITIS SEROLOGY
Hepatitis B
HBV ANTIBODIES
1. Antibodies to Hepatitis B Core Antigen (Anti-HBc)
IgM
o first to appear
o indicates current or recent infection
o useful for detecting infection in cases in which HBsAg is
undetectable (window period)
IgG
o indicates past infection and immunity
o lifetime persistence
VIRAL HEPATITIS SEROLOGY
Hepatitis B
HBV ANTIBODIES
2. Antibodies to Hepatitis B-Related Antigen (Anti-HBe)
Indicates convalescence and recovery