IRJMETS51200002327 Anticancer Review Article
IRJMETS51200002327 Anticancer Review Article
IRJMETS51200002327 Anticancer Review Article
16. Taxus brevifolia Gallu, Thuno Taxaceae Taxanes, taxol, Breast and ovarian
Flavonoids,
Terminalia Arjun Liver and colon
17. Combretaceae alkaloids, phenotic,
arjuna (Kahu) cancer
terpenoids
Tinospora
18. Giloy Menispermaceae Dichloromethane Oral cancer
cardifolia
Withandolides, Prostate and breast
Withania
19. Asgandha Solanaceae Withaferine cancer and colon
somnifera
somnirol cancer
Ziziphus Betulin, Betulinic
20. Chhoti ber Rhamnaceae Pancreatic Cancer
nummularia acid
Allium cepa Phytochemicals found in onions play a pivotal role in thwarting a range of cancer-causing
processes. A variety of strategies, including as heat shock protein suppression, p53 protein modulation, cell
cycle arrest, tyrosine kinase inhibition, and Ras protein (a class of cellular protein) expression blockade, are
employed by flavonoids to fight cancer. (Duthie, 2000) In a human phase I clinical trial, quercetin was tested as
a tyrosine kinase inhibitor. (Ferry, 1996) Numerous studies have shown that the organosulfur compounds
present in onions, such as cysteine, S-methyl cysteine, diallyl disulfide, and diallyl trisulfide, provide protection
against malignancies of the breast, stomach, liver, and colon (Moriarty, 2007). Quercetin is one of the onion
components that prevents cancer by inhibiting ROS-induced DNA damage and oncogenic tyrosine kinases. It
also improves drug bioavailability, which lowers metabolism and improves absorption of drugs like tamoxifen.
Organosulfur compounds found in onions have anti-cancer properties such as inducing detoxification enzymes,
improving antioxidant activities, promoting apoptosis, stimulating glutathione production, modulating
multidrug resistance, blocking carcinogen formation, inactivating chemicals that cause cancer, and improving
DNA repair (Kianian, Pharmacological Properties of Allium cepa, Preclinical and Clinical Evidences; A Review,
2021). Some other pharmacological activities are Anti-diabetic effects, Anti-platelet effects, Bone effects,
Cardiovascular effects, Gastrointestinal effects, Nervous system effects, Respiratory effects and Urogenital
effects (Kianian, Pharmacological Properties of Allium cepa, Preclinical and Clinical Evidences; A Review, 2020)