Week 2
Week 2
Protein Structure
Assoc. Prof. Dr. Gazi Erkan BOSTANCI
• They are responsible for catalyzing almost all the chemical reactions
in the cell (RNA has a more limited but important role, as we saw
earlier), they regulate all gene activity, and they provide much of the
cellular structure.
• There is speculation that life may have started with nucleic acid
chemistry only, but it is the extraordinary functional versatility of
proteins that has enabled life to reach its current complex state.
• Proteins can function as enzymes
catalyzing a wide variety of *Cytoskeleton is the skeleton for a cell and
maintains the shape of a cell.
reactions necessary for life, and
they can be important for the
structure of living systems, such as
those proteins involved in the
cytoskeleton.
• Many functional proteins are formed of more than one protein chain,
in which case the individual chains are called protein subunits. The
subunit composition and arrangement in such multisubunit proteins
is called the quaternary conformation.
• The structure adopted by a protein chain, and
thus its function, is determined entirely by its
amino acid sequence, but the rules that govern
how a protein chain of a given sequence folds
up are not yet understood and it is impossible
to predict the folded structure of a protein de
novo from its amino acid sequence alone.
• –There are several studies on this, including
recent ones.
• Clearly, the sequences that do occur are only a tiny fraction of those
possible. Often only a few sequence modifications are needed to
destabilize the three-dimensional conformation of a protein, and so it
is probable that the majority of these alternative sequences will not
adopt a stable conformation.
Amino acids are covalently linked together in
the protein chain by peptide bonds
• The primary structure of a protein is the sequence of
amino acids in the linear protein chain, which consists of
covalently linked amino acids. This linear chain is often
called a polypeptide chain.
Amino acid structure
• Most amino acids that change during evolution are found in regions
that are not structurally or functionally important, such as many of
the loops (or variable) regions.