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    Toxoplasma Gondii Questions

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    Hussien Sabry
    A baby was born with hydrocephalus, convulsions and fever, and the mother had a cat at home. This suggests a diagnosis of congenital toxoplasmosis, where the baby was infected in utero as tachyzoites crossed the placenta from the infected mother. The diagnosis can be confirmed by detecting IgM antibodies in the baby's blood through serology testing. A pregnant woman tested positive for IgG anti-Toxoplasma antibodies on a prenatal visit. The doctor would repeat the test in 2 weeks - a rising titer would indicate infection and treatment is needed, while no change would not require treatment.

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    Toxoplasma Gondii Questions

    Uploaded by

    Hussien Sabry
    53 views10 pages
    A baby was born with hydrocephalus, convulsions and fever, and the mother had a cat at home. This suggests a diagnosis of congenital toxoplasmosis, where the baby was infected in utero as tachyzoites crossed the placenta from the infected mother. The diagnosis can be confirmed by detecting IgM antibodies in the baby's blood through serology testing. A pregnant woman tested positive for IgG anti-Toxoplasma antibodies on a prenatal visit. The doctor would repeat the test in 2 weeks - a rising titer would indicate infection and treatment is needed, while no change would not require treatment.

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    Toxoplasma gondii questions

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    A baby was born with hydrocephalus, convulsions and fever, and the mother had a cat at home. This suggests a diagnosis of congenital toxoplasmosis, where the baby was infected in utero as tachyzoites crossed the placenta from the infected mother. The diagnosis can be confirmed by detecting IgM antibodies in the baby's blood through serology testing. A pregnant woman tested positive for IgG anti-Toxoplasma antibodies on a prenatal visit. The doctor would repeat the test in 2 weeks - a rising titer would indicate infection and treatment is needed, while no change would not require treatment.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    53 views10 pages

    Toxoplasma Gondii Questions

    Uploaded by

    Hussien Sabry
    A baby was born with hydrocephalus, convulsions and fever, and the mother had a cat at home. This suggests a diagnosis of congenital toxoplasmosis, where the baby was infected in utero as tachyzoites crossed the placenta from the infected mother. The diagnosis can be confirmed by detecting IgM antibodies in the baby's blood through serology testing. A pregnant woman tested positive for IgG anti-Toxoplasma antibodies on a prenatal visit. The doctor would repeat the test in 2 weeks - a rising titer would indicate infection and treatment is needed, while no change would not require treatment.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 10

    Case

    A newly born baby was born with Hydrocephalus,


    convulsions and fever. His mother gave a history
    of having a cat at home.
    a- What is your diagnosis?
    Congenital toxoplasmosis.
    b- How was the baby infected?
    Tachyzoites from infected mother crossed the
    placenta and infected the foetus.
    c- How can you confirm your diagnosis?
    By serology: Detection of anti toxoplasma IgM
    antibodies in baby’s blood.
    Case
    A pregnant female attending an outpatient clinic for
    pregnancy follow up was asked to do some
    investigations. Among these was testing for IgG anti-
    Toxoplasma antibodies that proved to be positive.
    a- How would the doctor proceed?
    The doctor should repeat the test after 2 weeks.
    b- How would the doctor interpret the results if:
    i- The titer remains the same ii- There is rising titer
    Treatment is not indicated Treatment is indicated
    c- Mention other immunoglobulin classes that are of value to
    the diagnosis. Detection of IgM anti-Toxoplasma antibodies
    d- If treatment is indicated, what drug would you prescribe?
    Spiramycin is the indicated drug
    M.C.Q.
    Manifestations of congenital toxoplasmosis can be
    first seen in:
    a- Neonatal period c- Adulthood
    b- Childhood d- All of the above
    Toxoplasmosis is fatal in AIDS patients by causing:
    a- Nephrotic syndrome
    b- Disseminated encephalitis
    c- Megacolon & constipation
    d- Megaoesophagus & dysphagia
    Oocysts of Toxoplasma gondii is found in:
    a- Brain of chronic patients b- Tissues of infected man
    c- Faeces of infected cats d- Faeces of infected man
    M.C.Q.
    Blindness caused by Toxoplasma is due to:
    a- Corneal opacity c- Optic neuritis
    b- Retinochoroiditis d- Panophthalmitis

    Hydrocephalus can occur in the following conditions:


    a- Cerebral malaria c- Cerebral toxoplasmosis
    b- Naegleria encephalitis d- Sleeping sickness

    Tissue cysts of Toxoplasma occur in:


    a- Stool of cat c- Human brain
    b- Stool of man d- Human blood
    Give reason
    Toxoplasma infections (during pregnancy) need
    ante natal as well as post natal follow up.

    Ante natal follow up is needed to detect activity of


    infection, serological test is done to detect IgM
    or rising titre of IgG.
    If either is found, this indicates a risk of foetal
    infection.
    Post natally, babies should be tested for IgM
    antibodies and when found,They should be
    treated
    M.C.Q.
    The Sequelae of infection with Toxoplasma depends
    on:
    a- immune status of infected human Tachyzoites
    b- age of infected human
    c- virulence of the infecting parasite strain
    d- non of the above Pseudocyst
    e- all of the above
    Tissue cyst of Toxoplasma is found in:
    Tissue cyst
    a- Stool of cat c- Meat of cattle
    b- Infected human blood d- All of the above
    Sporulated oocyst
    Give reason

    • Detection of anti Toxoplasma IgM antibodies in


    blood of a pregnant woman does not necessarily
    indicate foetal infection, while their detection in
    foetal blood does.
    Detection of IgM in mother’s blood indicates
    active infection of the mother only.
    IgM antibodies cannot cross the placenta, so
    its presence in foetal blood is an indication of
    foetal infection
    Give reason
    §Toxoplasma is considered an opportunistic disease.
    Toxoplasmosis is asymptomatic in the great majority
    of cases.
    If it infects an immunocompromized patient, the
    patient develops acute disseminated toxoplasmosis
    that may end fatally.

    § Immunodiagnosis is an important tool for diagnosis of


    Toxoplasmosis.
    Sampling may be impossible or hazardous e.g. cerebral
    toxoplasmosis.
    Question
    Mention 4 cerebral complications for congenital
    toxoplasmosis.

    1- Hydrocephalus

    2- Microcephaly

    3- Convulsions

    4- mental retardation
    State true or False

    • Congenital toxoplasmosis CAN NOT OCCUR when


    mothers have latent infection. False

    Congenital toxoplasmosis CAN OCCUR when


    mothers have latent infection when they become
    immunosuppressed and their old dormant
    infections flare up resulting in parasitaemia thus
    infecting the foetus.

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