Writing a coursework on a complex topic like Cystic Fibrosis can be a challenging and time-

consuming task. Cystic Fibrosis is a genetic disorder that involves multiple aspects, including
molecular biology, genetics, physiology, and medical treatments. Researching and comprehensively
covering these areas requires a deep understanding of the subject matter, access to credible sources,
and the ability to synthesize complex information.

Here are some challenges you may encounter when writing a coursework on Cystic Fibrosis:

1. Scientific Complexity: Understanding the molecular and genetic aspects of Cystic Fibrosis
can be daunting. Explaining these concepts in a clear and concise manner for a coursework
requires a strong foundation in biology and medical sciences.
2. In-Depth Research: Cystic Fibrosis is a constantly evolving field with new research
findings. Keeping up with the latest literature and incorporating relevant studies into your
coursework is essential but can be time-consuming.
3. Data Analysis: If your coursework involves data analysis, you may need to work with
statistical tools and interpret results accurately. This requires both a statistical background
and a good understanding of the specific data related to Cystic Fibrosis.
4. Critical Thinking: Developing a critical analysis of the existing literature, identifying gaps in
research, and proposing potential areas for further study is a crucial aspect of coursework.
This requires a high level of critical thinking and analytical skills.

Considering these challenges, individuals may find it beneficial to seek assistance. ⇒

HelpWriting.net ⇔ is one such platform that offers professional writing services. Ordering from
such a site can provide several advantages:

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3. Quality Assurance: Professional writing services often guarantee the quality and originality
of their work, providing you with a well-researched and well-written coursework.

While seeking help is an option, it's important to remember that academic integrity is paramount. If
you choose to use a writing service, make sure to collaborate ethically, using the provided material as
a reference and learning tool rather than submitting it as your own work.
If you decide to pursue any form of complementary or alternative medicine (CAM), it is important
to speak with your healthcare provider to ensure that it neither conflicts with your therapy nor causes
harm. Fitness plans should include stretching exercises (to promote flexibility), aerobic training (to
improve endurance and cardiorespiratory health), and resistance training (to build strength and
muscle mass). They can make the management of a chronic condition like CF more efficient and less
intrusive. These may include penicillins, cephalosporins, sulphonamides, macrolides, or tetracyclines.
The result is permanent and eventually leads to fibrosis of these bronchioles. Read our editorial
process to learn more about how we fact-check and keep our content accurate, reliable, and
trustworthy. CFTR-targeting therapies have recently been approved to treat the condition, but
because there are more than 2000 genetic changes capable of producing cystic fibrosis, only very few
patients are likely to respond to these drugs, making the treatment challenging, time-consuming, and
costly. Terms are as expected for this level scientifically. But Clevers’ technique is cool because he
has found a way to use cell material from the stomach, pancreas, brain, and liver to create their
miniature forms without embryonic stem cells. Emerging Therapeutic Approaches for Cystic Fibrosis.
Dietitians often work with patients to create individualized meal plans. Cystic Fibrosis Symptoms
Common Symptoms The symptoms of cystic fibrosis are numerous. Persistent bacterial infection,
inflammation, airway destruction, bronchiectasis, mucus plugged airways, goblet cell hyperplasia,
and disrupted cilia function. By doing so, you don’t have to exert as much energy to expel it. Next
Stage of Triple Combination CFTR Modulator Development Announced. Complementary therapies
are often embraced by people with cystic fibrosis to improve breathing and enhance appetite and
nutrition. Once a donor organ is found and determined to be a match for you, you are immediately
scheduled for surgery at a specialist hospital experienced in transplants. If the CTFR gene is mutated,
as is the case with this disease, the protein it produces will be flawed and cause mucus to thicken
abnormally throughout the body. They may experience atypical symptoms such as pancreatitis,
infertility, and recurring pneumonia. Diabetes may also develop as a result of cystic fibrosis.
Competing interests: We have read and understood BMJ policy on declaration of interests and
declare the following: BSQ has had no financial relationships with any organizations that might have
an interest in the submitted work in the previous three years; SMR has received travel
reimbursements to attend investigators’ meetings held by Vertex Pharmaceuticals, Novartis, Bayer
Healthcare, PTC Therapeutics. While the condition affects mainly the lungs and pancreas, the
symptoms appear mostly in the mouth and nose. In females, the cervix can become blocked by a
mucus plug, which prevents sperm reaching the egg. While cystic fibrosis usually occurs during the
first few years of a person’s life, the atypical form can occur when an individual is much older.
Cataracts have also been reported in children who use these drugs. Given the degenerative nature of
cystic fibrosis, LTOT may become necessary if the loss of lung function is causing disability and a
low quality of life. These cookies do not store any personal information. If the patient is too
dyspneic to eat, schedule Eating takes a lot of energy and resting can. You also have the option to
opt-out of these cookies. This is especially true for vitamin D; most people suffering from the illness
are unable to process it properly.
Atelectasis, bronchial hyperreactivity, asthma, hemoptysis, pneumothorax, pulmonary hypertension,
respiratory failure, sleep-related breathing problems, and symptomatic rhinosinusitis. Should Gene
therapy be allowed to prevent cystic fibrosis? The last step is forced coughs, which should help
release the mucus. They may experience atypical symptoms such as pancreatitis, infertility, and
recurring pneumonia. These digestive problems can lead to lack of nutrition, weight loss, and poor
growth and development. Write a review Update existing review Submit review Cancel It's good to
leave some feedback. Take all the preventive measures to prevent any kind of complicacy. This leads
to a special kind of diabetes unique to this illness. Sweat chloride test, pulmonary function testing
(PFT), arterial blood gas (ABG), and chest x-ray. Side effects include a headache, nausea, dizziness,
fatigue, diarrhea, and sinus congestion. In the “low-volume” model, the chloride channel is involved
in chloride outflow into the mucus that somewhat traps the sodium and water, retaining its fluidity.
And frequent antibiotic exposure disrupts the gut microbiota. Out of these cookies, the cookies that
are categorized as necessary are stored on your browser as they are essential for the working of basic
functionalities of the website. The gene is responsible for controlling the flow of fluids and salt in
and out of a person’s cells. SMR has an unlicensed patent held by the University of Alabama
Birmingham on the use of CFTR activators for the treatment of respiratory diseases unaffected by
acquired or genetic causes of CFTR dysfunction. Terms are as expected for this level scientifically.
Finally, you are removed from the heart-lung machine once your lungs are working. The CFTR
channel opens and allows chloride ions to diffuse out of the cell into the mucus. Other IV lines are
placed in your neck, wrist, collarbone, and groin to monitor your heart rate and blood pressure.
Different Export Prices of Medicinal Drugs.pdf Different Export Prices of Medicinal Drugs.pdf
Cystic Fibrosis 1. For example, if you have a lung infection, the force required to breathe can burn
far more energy than you are able to obtain from food. The life expectancy is getting longer, from 10
years to around 40 years of age. Sweat testing involves the application of a medication that
stimulates sweating (pilocarpine). Cilia beat the mucus into the back of the mouth, where it is either
swallowed (stomach acid kills microorganisms) or coughed out. Spelling and punctuation are
accurate, and the grammar is mainly accurate. Dr. Madduru Muni Haritha Bursitis is inflammation or
irritation of a bursa sac. Cystic fibrosis is a hereditary disease characterized by lung congestion and
infection along with malabsorption of nutrients by the pancreas. It should be assured that they are
getting sufficient oxygen during their sleep. This test helps measure the salt present in a baby’s sweat
and is one of the most conclusive tests regarding cystic fibrosis. There are a number of commonly
used techniques, some of which may be easier for adults than young children.
Pancreatitis (inflammation of the pancreas) may develop. The body produces thick and sticky mucus
that can block the lungs and obstruct the pancreas. The more infections you have, the more damage
your lungs will sustain. Complementary therapies are often embraced by people with cystic fibrosis
to improve breathing and enhance appetite and nutrition. Side effects include a headache, nausea,
dizziness, fatigue, diarrhea, and sinus congestion. When the CFTR defective, secretions become
thick and sticky. With that being said, the oral use of a ginseng solution in mice was shown to
disrupt the protective biofilm of the Pseudomonas auruginosa bacteria commonly associated with CF
lung infections. (The same result cannot be guaranteed in humans, however.). These drugs are having
a positive impact on the lives of people with cystic fibrosis and are potentially disease modifying.
Once stabilized, you are transferred to a hospital room for anywhere from one to three weeks to
begin your recovery. Sweat chloride test, pulmonary function testing (PFT), arterial blood gas
(ABG), and chest x-ray. For example, taking a breath and holding it for three seconds helps with
mucus buildup. These digestive problems can lead to lack of nutrition, weight loss, and poor growth
and development. The salt content draws water from surrounding tissue and, by doing so, thins the
mucus in the lungs. Therefore, see to it that the patient consumes extra nutrients and calories so that
they don’t become malnourished. Since children with cystic fibrosis lose excessive salt in their
sweat. The discovery of the CFTR gene in 1989 has led to a sophisticated understanding of how
thousands of mutations in the CFTR gene affect the structure and function of the CFTR protein.
Burkholderia cepacia: Conclusion: Infographics Of Cystic Fibrosis. Side effects include bloating,
diarrhea, constipation, headaches, and cramps. If the CTFR gene is mutated, as is the case with this
disease, the protein it produces will be flawed and cause mucus to thicken abnormally throughout
the body. There are more than 2,000 that can cause CF, and around 80 percent of cases are
associated with a specific mutation known as the deltaF508. Moreover, your lung functions would
need to have decreased to a point where mechanical ventilation is required to perform even the most
basic of tasks. Because of poor food absorption children get poor weight gain. Airway clearance
techniques can be used for preventing mucus buildup in the respiratory system. Associated with the
research program and planning to opt for a doctoral program in nanobiotechnology in a reputed
organization. Children with cystic fibrosis can have chronic cough, sputum production, wheezing,
frequent lung infections (recurrent pneumonia or bronchitis). Verywell Health uses only high-quality
sources, including peer-reviewed studies, to support the facts within our articles. Exercise not only
helps maintain lung function, it reduces your risk of CF-related complications such as diabetes, heart
disease, and osteoporosis. That said, if your child has CF, it's wise to speak with your pulmonologist
to get a better sense of your child's limitations, which activities may be better than others, and what
precautions may need to be taken to prevent infection from other kids and even shared sports
equipment. This test looks for elevated levels of immunoreactive trypsinogen (IRT), an indicator of
CF. Emerging Therapeutic Approaches for Cystic Fibrosis.
Out of these cookies, the cookies that are categorized as necessary are stored on your browser as
they are essential for the working of basic functionalities of the website. While generally considered
safe, turmeric overuse may cause bloating and indigestion. CF is a complex, multi system disease
requiring a co-management by health care professionals because of the multiple disorders seen in a
CF patient. This leads to malfunctions in calcium production, which can result in weakened bones
prone to fractures. Adults, by contrast, are given a Lung Allocation Score (LAS) of 0 to 100 based
on the severity of their condition. To compensate for this loss and maintain a healthy weight, you
need to embark on a high-fat, high-calorie diet. This is particularly useful for confirming a diagnosis
following a positive sweat test or as part of a newborn screening program. Cystic fibrosis
transmembrane conductance regulator protein. Next Stage of Triple Combination CFTR Modulator
Development Announced. Encourage regular exercise Exercise helps maintain physical wellness and.
Complications of lung transplant include infection, bleeding, and sepsis. Join our team of reviewers
and help other students learn. This category only includes cookies that ensures basic functionalities
and security features of the website. We use cookies to personalize content and ads, to provide social
media features and to analyze our traffic. Having two deltaF508 copies causes the severe deformity
of the protein. Zithromax (azithromycin) is a broad-spectrum antibiotic commonly used for this.
Sweat chloride test, pulmonary function testing (PFT), arterial blood gas (ABG), and chest x-ray.
Inhaled antibiotics are used prophylactically to prevent bacterial infection but can also be used
during acute exacerbations. Read our editorial process to learn more about how we fact-check and
keep our content accurate, reliable, and trustworthy. The trapped enzymes can also damage the
pancreas, which can lead to diabetes. Sickle cell disease has a protective effect against complications
associated with hyphema. In some children if a sputum test is not possible then a bronchoscopy
might be needed. However, take note that, even though the powder is just 1 percent, taking any more
could lead to more damage. Techniques include chest physiotherapy, positive expiratory pressure
(PEP) therapy, and exercise. If they puff up, it indicates that the cells are now correctly balancing salt
and water, implying that the drugs are working properly and would be effective in the patient from
whose cells the mini-gut was made. Life expectancy has significantly reduced through medical
advances that have been made in recent years. For example, taking a breath and holding it for three
seconds helps with mucus buildup. This allowing bacteria to thrive and can be life-threatening. Take
all the preventive measures to prevent any kind of complicacy. This causes a range of health
problems including an impaired ability to absorb sufficient calories and repeated chest infections.
The disruption of the chloride transport causes thick secretions, and sodium is absorbed in the
airways, pancreas, and bile ducts. The Cystic Fibrosis Foundation recommends the following daily
caloric intake for women, men, toddlers, children, and teenagers, depending on weight goals. Health
Cystic Fibrosis Cystic Fibrosis Therapy Disease Disease And Condition -- -- Follow Written by
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Privacy Terms Text to speech Teams. This is especially true for vitamin D; most people suffering from
the illness are unable to process it properly. Cystic fibrosis is a hereditary disease characterized by
lung congestion and infection along with malabsorption of nutrients by the pancreas. With cystic
fibrosis, the accumulation of mucus in the lungs provides bacteria the perfect breeding ground for
infection. Inhaled antibiotics are only used after you've used a bronchodilator and mucolytic and
performed airway clearance. It is mandatory to procure user consent prior to running these cookies on
your website. Cystic Fibrosis Remedies and Supplements As mentioned earlier, there is no cure yet
for cystic fibrosis. You consent to our cookies if you continue to use our website. Ok. This
supplement helps alleviate many of cystic fibrosis’ symptoms. For example, vitamin D can regulate
calcium, which leads to much healthier teeth, bones and cartilage. If the CFTR gene doesn’t work the
way it should, sticky mucus builds up in your body. Techniques include chest physiotherapy, positive
expiratory pressure (PEP) therapy, and exercise. This leads to accelerated permanent loss of lung
function. Mixed respiratory acidosis and metabolic alkalosis. Because of this, if you’re experiencing
these symptoms more often than your peers, it might be worth checking with your doctor. Could
also develop their own conclusions as to how the disease may be treated or evaluate treatments that
are available for the condition now rather than only describing symptoms. Does not explore the
reasons for infertility in the males which could be another possible route to explore to increase the
depth of analysis showed by the candidate. That said, if your child has CF, it's wise to speak with
your pulmonologist to get a better sense of your child's limitations, which activities may be better
than others, and what precautions may need to be taken to prevent infection from other kids and
even shared sports equipment. This may involve oxygen therapy and enteral nutrition. The life
expectancy for a sufferer has increased from 5 to 31 years of age in the last 43 years, and scientists
are continually getting closer to finding a cure through gene therapy and drugs. Any cookies that
may not be particularly necessary for the website to function and is used specifically to collect user
personal data via analytics, ads, other embedded contents are termed as non-necessary cookies.
Hyperinflation, thick tenacious mucus, and airway obstructions that lead to atelectasis. Goes on to
explore the content with in depth gene analysis which is what I would expect from a well rounded
higher level A level candidate, with multiple diagrams included and explained. So It’s necessary to
avoid contact with another person with CF otherwise both will get infected. But while research is
being done to find a cure, some supplements can help ease the symptoms: Vitamin A The vitamin A
supplement is one of the more helpful general supplements out there. Moreover, your lung functions
would need to have decreased to a point where mechanical ventilation is required to perform even
the most basic of tasks. The recommended dosage for this supplement is one softgel per day,
together with a meal. Administer oxygen therapy and receive digoxin To decrease the lungs work.
Once the transplant is completed, chest tubes are inserted to drain air, fluid, and blood. Mostly used
for treating the lung damage caused by thick mucus and infection.
Genetic Analysis with the help of clinical exome sequencing is also possible now. Next Stage of
Triple Combination CFTR Modulator Development Announced. Cystic fibrosis can be inherited, but
only if both parents are carriers. It is a condition associated with poor sleep quality, reduced exercise
tolerance, and the loss of muscle mass. A therapist claps the CF patient’s chest and back while they
sit, stand, or lie in a position that should help to free up mucus. We'll assume you're ok with this, but
you can opt-out if you wish. If a person suffers from cystic fibrosis, it entails inheriting the mutated
copy of the gene from both their parents. Someone with one mutated gene and one normal gene is a
carrier. Apart from that, vitamin A can also help with slight skin saltiness that is common in those
suffering from cystic fibrosis. Bursitis is inflammation or irritation of a bursa sac. These symptoms
are quite common, so a few cystic fibrosis patients go without diagnosis until later in life. Search or
use up and down arrow keys to select an item. Competing interests: We have read and understood
BMJ policy on declaration of interests and declare the following: BSQ has had no financial
relationships with any organizations that might have an interest in the submitted work in the previous
three years; SMR has received travel reimbursements to attend investigators’ meetings held by Vertex
Pharmaceuticals, Novartis, Bayer Healthcare, PTC Therapeutics. The techniques aim to dislodge
mucus from the lung's air sacs so that you can cough it out. Research from the University of
Copenhagen suggests the disruption of the biofilm by ginseng may impede bacterial colonization and
support antibiotics in controlling infections. Pulmonary indications include advanced chronic
obstructive pulmonary disease (COPD), hypercapnia, and severe hypoxemia when the disease is
advanced. Tobramycin (TOBI), aztreonam (Cayston) and colistemethate (Colistin). If the CFTR gene
doesn’t work the way it should, sticky mucus builds up in your body. Common Symptoms What
happens to the lungs in Cystic Fibrosis. While much excitement been centered around the
introduction of newer cystic fibrosis drugs, self-care still remains the foundation of CF treatment.
Based on that, your age, fitness level, and overall health, a specialist dietitian can help design a diet
with the right balance of protein, carbohydrates, and fats. These digestive problems can lead to lack
of nutrition, weight loss, and poor growth and development. Children can also have persistent loose
or oily stools and failure to thrive (inability to gain weight despite having a good appetite) and poor
growth. Cystic fibrosis is an autosomal recessive disorder caused by mutations in the CFTR (Cystic
Fibrosis Transmembrane conductance Regulator) gene. No part of this website or publication may be
reproduced, stored, or transmitted in any form or by any means, electronic or mechanical, including
photocopy, recording, or any information storage and retrieval system, without permission in writing
from the copyright holder. Increased concentrations of NaCl (sodium chloride) and K (potassium) in
the sweat. These help in improving the patient’s bowel movements and preventing vitamin
deficiencies and malnutrition. Together, this increases the concentration of solutes in the mucus,
causing water to travel by osmosis out of the cell and into the mucus. They are delivered either orally
or with a nebulizer or DPI.