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    Mpharm MPT 201 (2) Advanced Pharmaceutical Analysis 2 2012

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    Susmita Ghosh
    The document is an exam for an Advanced Pharmaceutical Analysis course. It contains multiple choice questions, short answer questions, and long answer questions testing knowledge of various analytical techniques. The questions cover topics like instrumental analysis methods (ICP-AES, ESR, XRD), official pharmacopeial assays (for ascorbic acid, diclofenac, antibiotics), and specific analytical techniques (scintillation counting, oxidative coupling reactions, diazotization).

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    © All Rights Reserved
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    Mpharm MPT 201 (2) Advanced Pharmaceutical Analysis 2 2012

    Uploaded by

    Susmita Ghosh
    13 views4 pages
    The document is an exam for an Advanced Pharmaceutical Analysis course. It contains multiple choice questions, short answer questions, and long answer questions testing knowledge of various analytical techniques. The questions cover topics like instrumental analysis methods (ICP-AES, ESR, XRD), official pharmacopeial assays (for ascorbic acid, diclofenac, antibiotics), and specific analytical techniques (scintillation counting, oxidative coupling reactions, diazotization).

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    The document is an exam for an Advanced Pharmaceutical Analysis course. It contains multiple choice questions, short answer questions, and long answer questions testing knowledge of various analytical techniques. The questions cover topics like instrumental analysis methods (ICP-AES, ESR, XRD), official pharmacopeial assays (for ascorbic acid, diclofenac, antibiotics), and specific analytical techniques (scintillation counting, oxidative coupling reactions, diazotization).

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    13 views4 pages

    Mpharm MPT 201 (2) Advanced Pharmaceutical Analysis 2 2012

    Uploaded by

    Susmita Ghosh
    The document is an exam for an Advanced Pharmaceutical Analysis course. It contains multiple choice questions, short answer questions, and long answer questions testing knowledge of various analytical techniques. The questions cover topics like instrumental analysis methods (ICP-AES, ESR, XRD), official pharmacopeial assays (for ascorbic acid, diclofenac, antibiotics), and specific analytical techniques (scintillation counting, oxidative coupling reactions, diazotization).

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 4

    http://www.makaut.

    com

    Name : ……………………………………………………………
    Roll No. : ……………………………………………..…………..
    Invigilator's Signature : ………………………………………..

    CS/M.PHARM/SEM-2/MPT-201(2)/2012
    2012
    ADVANCED PHARMACEUTICAL ANALYSIS –II
    Time Allotted : 3 Hours Full Marks : 70

    The figures in the margin indicate full marks.


    Candidates are required to give their answers in their own words as
    far as practicable.

    GROUP – A
    ( Multiple Choice Type Questions )

    1. Choose the correct alternatives for any ten of the following :


    10 × 1 = 10
    i) Gibbs reagent is chemically
    a) 3-methyl-2-benzthiazolinone hydrazone
    hydrochloride
    b) P-dimethylamino benzaldehyde
    c) 2, 6-Dichloroquinone-4-Chlorimide
    d) Ferric chloride.
    ii) The mechanism of colour formation by MBTH is
    a) Oxidation and coupling
    b) Reduction and coupling
    c) Diazotization
    d) Complexation.

    30428(M.PHARM) [ Turn over


    CS/M.PHARM/SEM-2/MPT-201(2)/2012

    iii) Gonimeter is device used in

    a) ICPAAS

    b) ESR Spectroscopy

    c) RIA

    d) X-ray diffraction Spectrometry.

    iv) The official I.P. assay of Ascorbic acid is done by

    a) Spectrophotometry

    b) HPLC

    c) Iodimetry

    d) Non-aqueous titration.

    v) The mechanism of scintillation is

    a) Antigen-antibody reaction

    b) Emission of photons by radiation

    c) Change in spin of electrons in orbital

    d) None of these.

    vi) ESR spectra is not exhibited by

    a) Dimagnetic substances

    b) Transition metals

    c) Ferromagnetic substances

    d) Triplet electronic states.

    vii) The I.P. assay of diclofenac is based upon

    a) non-aqueous titration b) Spectrophotometry

    c) HPLC d) Argentometry.

    30428(M.PHARM) 2
    CS/M.PHARM/SEM-2/MPT-201(2)/2012

    viii) In assay of antipyrine using PDAB reagent in conc.


    H2 SO4 the λmax is approximately observed at

    a) 550 nm b) 400 nm

    c) 530 nm d) 513 nm.

    ix) The free radical reactions can be measured by

    a) ESR spectroscopy

    b) X-ray fluorescense Spectroscopy

    c) ICPAAS

    d) X-ray diffraction Spectrometry.

    x) Nebulizer is an essential component of

    a) Scintillation counter

    b) Colorimeer

    c) ICPAAS

    d) X-ray diffractometer.

    xi) The ideal reagent used for colour formation by oxidation


    followed by charge transfer is
    a) NaNO2 and HCl in cold condition

    b) PDAB

    c) NBS-metol-sulphanilamide

    d) Gibbs reagent.

    xii) ICPAA can determine

    a) Elemental compostion of a sample

    b) Crystal characterization

    c) Oxidation state of elements

    d) Functional group identification.

    30428(M.PHARM) 3 [ Turn over


    CS/M.PHARM/SEM-2/MPT-201(2)/2012

    GROUP – B
    ( Short Answer Type Questions )
    Answer any three of the following. 3 × 5 = 15
    2. Write the difference between energy dispersive and wave-
    length dispersive X-ray fluorescence spectroscopy.
    3. Describe in brief the instrumentation of ESR spectroscopy.
    4. How can you differentiate X-ray diffraction analysis of crystal
    and powder ?
    5. Describe the I.P. assay of diclofenac tablets.
    6. How are primary aromatic amines used as chromogenic
    agent ? Explain.

    GROUP – C
    ( Long Answer Type Questions )
    Answer any three of the following. 3 × 15 = 45
    7. Write about the I.P. assay of any four antibiotic drugs and
    their formulations. Describe in brief the assay methods
    which are generally employed in pharmacopoeia for assaying
    pharmaceuticals. Why are the assey method of bulk drugs
    generally differ from their formulations ? 12 + 2 + 1
    8. Write about the theory, instrumentation, application and
    limitations of inductively coupled plasma atomic absorption
    spectroscopy.
    1 1
    9. Write notes on the following : 7 +7
    2 2
    a) Oxidative coupling reactions using MBTH
    b) Diazotization followed by coupling.
    10. What is ESR spectroscopy ? Describe its similarity and
    differences with NMR spectroscopy. What information can
    be obtain from ESR spectrum ?
    1 1
    11. Describe the following : 7 +7
    2 2
    a) Scintillation counter
    b) I.P. assay of insulin and preparations.

    30428(M.PHARM) 4

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