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CS / M .Phar m/SE M- 1/MP T- 101/2 013- 14
201 3
[oDE RN PHARMACEUTICAL ANALYTICAL TECH NIQU E

/me Allotted : 3 Hour s Full Mark s : 70
The figure s in the n1argin indica te full mark s.

---andi dates are required to give their answ ers in their own word s
as far as practi cable .
GROU P - A
( Multi ple Choic e Type Ques tions )
Ch oose the corre ct altern atives for any ten of the follow ing :
10 X 1 = 10
i) \Vhic h of the follow ing will h ave magn etic mom ent ?
a)
b) 12c
6
c) 160
8
12
dJ 8 16 ·
12(M.Phan n) [ Tu m over
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cs / M.Pharrn/ SEM-1/MPT -101/2013-14
ii) What is the multiplicity expected m NMR for U
hydrogen marked by ' * ' in the following compound ?
a) Singlet
b) Quartet
c) Triplet
d) Heptet.
iii) What is the principle of G LC ?
a) Adsorption
b) Partition
c) Both (a) and (b)
d) None of these.
iv) 'ppm' is associated with which spectroscopy ?
a) IR
b) UV
c) NMR
d) Mass.
40412(M.Pha
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2
CS/ M.Pharm / SEM-1 / MPr-101 / 2013-14
v) Quartz curette is used in UV spectrophotometer
because glass curette
a) absorbs visible light
b) absorbs UV light
c) reflects UV light
d) refracts UV light.
vi) Which of the following alkenes would have the largest
a)
b)
c)
HaC CH3
d) ' C=C /
H3C
/ ' CH3
3 ( Tum over
CS / M .Pharm / SEM-1 / MPT-101 / 2013- 14
vii) A compound shows prominent stretching frequency
1
wave no . 3200 cm- 1 , 2900 cm- , 1715 cm- 1 a
cm•- l. What functional group is present in ,

1120
sample?
a) Alcohol
b) Acid
c) Ester
d) Ketone .
viii) The main technique used to analyze crystal structu1

a sample is
a) Gas chromatography
b) Atomic absorption spectroscopy
c) X-r ay diffraction
d) Ultraviolet-visible spectroscopy.
ix) In gel permeation chromatography the separation 1
place according to the phenomenon of
a) adsorption
b) partition
c) ion exchange
d) · of the molecule .
shape an d size
.Pharm)
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4
CS/M .Pharm/SEM -1 /MPT-101/2 013-14
X ) Which of the following is used as an internal standard

fo r water soluble co1npounds while recording NMR
spectra?
a) TMS
b) DSS
c) Both (a) and (b)
d) None of these.
xi) Geiger-Mulle r counter is used in
•
a) radio-pharma ceuticals
b) EUSA
c) gel electrophores is
d) TLC.
xii) Xenon discharge lamp is used as source in
a) mass spectrophoto meter
b) IR spectrophoto meter
c) UV spectrophoto meter
d) visible spectrophoto meter.
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5
4
CS/ M.Ph arm/SE M-1 / MPT-lO l / 2 0 l 3 - l
GROU P-B
I Short Answe r Type Quest ions l

Answe r any three of the followi ng. 3 x 5 ""
Write down the princip les of Radio immun oassay (RIA) . Wl
2.
are the applica tions of RIA? 3·
Write a detaile d note on detecti ons used in GLC .
3.
How will you detect the presen ce of aroma tic ring in an
4.
0
spectru m ? How will you differe ntiate I 2 ° and 3 ° alcoh
,
by looking at their spectr um ?
5. What are the differe nt metho ds of quanti tative analys is

UV-visible spectro scopy ? What is the effect of conjug ati
on Amax ? 3·
6. What is chemic al shift ? Write a detaile d note on s hieldi

effect in NMR. 1
GROU P - C
( Lo_n g Answe r Type Quest ions )
Answe r any three of the follow ing . · 3 x 15 =
7. a) Explai n the operat ing princip le of flame photom eter.
b) Discu ss the interfe rences in flame photom etry.
c) What are the limitat ions of flame photom etry ?

8. a) Write a note On th e princip
. . le of Atomi c Absorp ti
Spectro scopy.
b) Discus s the advant ages and

disadv antage s of Atorr
Absorp tion Spectr oscopy .
404'12(M .Phann )
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CS/ M .Pha rm / SEM - 1/ MPT- 101 /201 3-1 4
Wha t is anti biot ic ? Wha t is the sour ce of anti biot ics

?
9. a)
Brie fly desc ribe the proc ess of anti biot ic assa y.
the proc edu re of eval uati on of leaf by

b) Exp lain
+ 6
dete rmin ing stom atal num ber and stom atal inde x. 9
met ry. Wh at
/ 10. Disc uss the theo ry beh ind mas s spec trop hoto
mas s
/ are the diff eren t com pon ents and app lica tion s of
spec trop hoto met ry ? 5 +5 +5
id
11 . a) Wri te on the vari ous aspe cts of Hig h Perf orm anc e Liqu
Chr oma togr aph y (HPLC) tech niqu e.
by
b) How a part icul ar seco nda ry met abo lite can be isol at ed
9 +6
usin g colu mn chro mat ogra phy ?
--- --- --- --- -

va ,nc : .. .. . . . . . . ... . . . ... ... ........ . .. . . . . ... .. ................... ....... .
?oil No. : ...... . • • • • • • • • • • •• · · · · · • · · • · · • • • • • · · · •• • •• • • •. . ..... ... ......... .
rwig ilat or's Signature : ... ........ ......... ..... ................... .. .
CS/M.Phar m/SEM-l/M PT-105(2)/ 20i3-14

2013
MODERN CONCEPT S OF PHARMACOLOGY
Ynte Allotted : 3 Hours Full Marks: 70
The _figures in the margin indicate full marks.

Candidates are required to-give their answers in their own words
as far as practicable.
GROUP-A
( Multiple Choice· Type Questions )
Choose the correct alternatives for the following : 10 x 1 = 1 O
i) Digoxin can produce
a) tachycardia b) bradycardia
c) heart block d) all of these.
ii) Nitric Oxide ( NO ) relaxes smooth muscle in the vessel

wall by activating
a} cAMP b) PKc
c} PKG d} cGMP.
426 ( M.Pharm)
[ Tum over

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- 1/MJYf - 105(2) / 2013 Pharmacy
- J4 Books
ill) Potass h.1111 cha nnel open er i s
a) vera1.x1n1il
b) sodiu 1n n itroprusside
c) nunoxidil
d) ainirtnone .
iv ) Alopecia and curling of hair is s een with
a) ethosuximid e b) carbamazepi ne
c) phenytoi·n d) valproic acid .
v) MAOB inhibitor is
a) selegilin e b) tolcapone
c) ropinirole d) . b en serazide.
vi) The s tem cell responsible for pla cental cell is
a) totipotent b) plu ripotent
c) multipoten t d) oligopotent.
vii) The cell lin e which gives the epid ermal cell is
a) endoderm b) ectoderm
c) m esoderm d) fibrobla st.
viii) Pharmacoge netics occurs due to action of
a) h epatotoxicity
b) allele
c) drug a ction
d) chemothera peutic a ction.

40426 ( M .Ph
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CS/M.Pharm/SEM-1/MPT-105(2)/2013-
txJ Antlsense animals are required for
a) clam and quite animals
b) drug action evaluation
c) GLP practice
d) GMP practice.
x) Antisense therapy is implanted by
a) blocking mRNA
b) drug action
c) by implementing a n aesthesia
d) chemotherapeuti c dru g.
GROUP - B
( Short Answer Type Questions )
Answer any three of the f ollo\ving. 3 X 5 = 15
2. Briefly discuss antipsychotic drugs.
Write about the antisense therapy.
Mention the role ofTNF-a and interleukin in inflammation.
a abort note on transgenic animals.

ITumowr
CS/M .Pharm/SEM - 1/MIYJ'- 105(2) / 2013 - 14
GROUP - C
( Long Answer Type Questions )
Answer any three of the following . 3 X 15 ~
7. \ Vh at do you m ean by phar1nacogenetics ? How do('

in fl uence the drug responses ? 7
8. \\' r ite in d etail about the antisense therapy. How

a n ti sense therapy can be used in cancer and A
treatm ent ? 9 +r ~
9. Mention the physiological function of nitric oxide ( ~
Discuss the pharmacotherapy of h ypertension . 5
10 . Wha t is the role of angiogenesis and apoptosi:

development of cancer ? Discu s s the mode of actic
irinotecan, paclitaxel, etoposide and cisplatin in treatme
cancer. 5
I 1 . Describe about the treatment of the following :
a) Epilepsy
b) Parkinsonism
c) Ischemic heart disease .

.... . .... . .. . . .... ... .. .
. . ... ..
trne : .... . . . .. ··· ·· · .. . . .. .... . . ... . . . . ....
·· ·· ··· ··· .... .... .. .... .... .... ... .... .... .. ··· ··
'll No. .. ···· ··· ··· ••" ' "'
• •· • • •• • •• • •• •• • •• • •• • •• • •• • • • • ••
;igi lato r 's Sig na tu r e : . •• •• • • •• •• · ••
( 1) / 20 13 -1 4
CS I M .Ph ar m / SE M- 1/ MP T-1 05
20 13
TOXI CO LO GY
,ffARMACOLOGY AN D GE NE RA L
F ull M ark s : 70
n e All otte d : 3 Ho urs
u ll ma rks .
The jig u res in the ma rgi n ind ica tef
ir an sw ers in the ir o wn wo rds
;a ndi dat es are r eq uir ed to g ive the
as Ja r as p ra c tica ble .
GR OU P- A
( Multi ple Ch oic e Ty pe Qu est ion s )
a n y ten of the fol lowing
Ch oos e the cor rec t alt ern a tiv es for 10 x I = 10
qu est ion s :
i) A dru g wh ich exh ibi ts tolera n ce is
a) As pir in b) Mo rp hine
c) Ra nit idi ne d ) Rifa mp ici n .
ii) Dr ugs ma y b e exc ret ed via

a) Th yro id b) Ha ir
c) Pla telet d) Sp lee n .
ich p ha se ?
iii ) Ph arm aco vig ila n ce cor r esp on d s to wh
a) Ph ase I b ) Ph a s e 2
c) Ph ase 3 d) ·Ph ase 4.
Ca ra ge en an is us ed in wh ich s tud y
?
iv)
a} An ti- inf lam ma tor y b) Am ne sis
c} An xie ty d) All of the se.
4 18( M .Ph arm ) [T urn ove r

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-105 3-1 4
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CS / M.P
usin g
v) Bioa s s ay of a cety l cho line can be per form ed
a) Rec tus abd om inu s of frog
bJ Ileu m of gui nea pig

c) both (a) and {b)
d) non e of thes e.
vi) The che lati ng age nt(s ) use d for trea tme nt of
pois onin g is / are
EDT A b) Dim erca pro l ( B
a)
Suc cim er d) all of the se .

c)
v U) CPCSEA stan ds for
a) Com mit tee for the Pur pos e of Con trol
Sup erv isio n of Exp erim ents on Ani mal s
b) Com mit tee for the Pur pos e of Car e and Supe
of Exp erim ents on Ani mal s
c) Com mit tee for the Pur pos e of Car e and San
Exp erim ents on Ani mal s
d) Non e of the se .
v iii) P-g lyco pro tein is
a) ABC -tra nsp orte r b) · CA B-t ran spo rter
c) BCA -tra nsp orte r d} non e of the se .
ix} Delayed typ e hyp ers ens itiV ity is hypersen

reac tion of
a) type I b} typ e II
c) type III d) typ e IV.
of
x) N-acetyl -p-b enz oqu ino nei min e cau ses tox icit y
a) live r b) kid ney
c} eye d) ear .
4041 B(M .Ph arm ) 2

CS/M .Pha rm/S EM-1 /MPT -105 (1 )/20 13-1 4
xi)
The Ame s test is a biolo gical assa y to asse ss the
muta geni c pote ntial of chem ical com poun ds. The
bact erium used in the test is a strai n of
a) Salm onell a typh tmur tum
b) Stap hyloc occu s aure us
c) Vibri o chole rae
d) none of these .
xii) Conv ulsio ns may be indu ced in mice by adm inist ering
a) Pent elen etetr azol b) Aspi rin
c) Diaz epam d) Xylo caine .
GRO UP- B
( Shor t Answ er Type Que stion s )
Answ er any three of the follow tng. 3 X 5 = 15
2. Disc uss brief ly abou t phar mac odyn amic drug inter actio ns.
3. Disc uss abou t the phen ome non of toler ance and
depe nden ce.
4. Disc uss brief ly CPC SEA guid eline s.
). Write a shor t note on lead toxicity.
6. Wha t is bioa ssay ? Disc uss its adva ntag es and
disad vant ages .
GRO UP- C
( Long Answ er Typ e Que stion s )
Answ er any three of the follow tng. 3 X 15 = 45
7.
Disc uss the basi c princ iples of toxic olog y. Disc uss in deta il
abou t hype rsens itivit y reac tions . 5 + 10
8.
Discuss abou t heav y meta l toxic ity and the treat men t
appr oach es for it. Expl ain in deta il abou t the antid otes used
in heavy meta l toxic ity.
7 +8
o4 l8(M .Pha rm)

3 [Tur nove r
CS/M .Phar m/SE M-1 /MPT- 105( I )/201 3-14
9. Discu ss the screen ing appro aches for the follow1ng h~

~.J !Jt:
drugs : 2~
a) Analg esics
b) Anti-i nflam mator y drugs .
10. Discu ss the metab olism of drugs . What are the diff(
steps of metab olism ? Give the signif icance of en,
induc tion. 4+
11 . Write short notes on any two of the follow ing : 2
a) Adver se Drug React ion types
b) Bioes say of histam ine
c) Histop atholo gy and its applic ations .

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CS / M .Phar m/SE M- 1/MP T- 101/2 013- 14

[oDE RN PHARMACEUTICAL ANALYTICAL TECH NIQU E

The figure s in the n1argin indica te full mark s.

( Multi ple Choic e Type Ques tions )

ii) What is the multiplicity expected m NMR for U

hydrogen marked by ' * ' in the following compound ?

iii) What is the principle of G LC ?

c) Both (a) and (b)

iv) 'ppm' is associated with which spectroscopy ?

because glass curette

a) absorbs visible light

vi) Which of the following alkenes would have the largest

cm•- l. What functional group is present in ,

viii) The main technique used to analyze crystal structu1

b) Atomic absorption spectroscopy

ix) In gel permeation chromatography the separation 1

place according to the phenomenon of

X ) Which of the following is used as an internal standard

c) Both (a) and (b)

xi) Geiger-Mulle r counter is used in

xii) Xenon discharge lamp is used as source in

a) mass spectrophoto meter

d) visible spectrophoto meter.

140412(M .Pharm) Visit MyPharmaGuide.Com for more Pharmacy Books

I Short Answe r Type Quest ions l

by looking at their spectr um ?

5. What are the differe nt metho ds of quanti tative analys is

6. What is chemic al shift ? Write a detaile d note on s hieldi

7. a) Explai n the operat ing princip le of flame photom eter.

b) Discu ss the interfe rences in flame photom etry.

c) What are the limitat ions of flame photom etry ?

b) Discus s the advant ages and

Wha t is anti biot ic ? Wha t is the sour ce of anti biot ics

the proc edu re of eval uati on of leaf by

--- --- --- --- -

Visit MyPharmaGuide.Com for more Pharmacy Books

?oil No. : ...... . • • • • • • • • • • •• · · · · · • · · • · · • • • • • · · · •• • •• • • •. . ..... ... ......... .

rwig ilat or's Signature : ... ........ ......... ..... ................... .. .

CS/M.Phar m/SEM-l/M PT-105(2)/ 20i3-14

The _figures in the margin indicate full marks.

Choose the correct alternatives for the following : 10 x 1 = 1 O

i) Digoxin can produce

c) heart block d) all of these.

ii) Nitric Oxide ( NO ) relaxes smooth muscle in the vessel

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iv ) Alopecia and curling of hair is s een with

vi) The s tem cell responsible for pla cental cell is

a) totipotent b) plu ripotent

c) m esoderm d) fibrobla st.

viii) Pharmacoge netics occurs due to action of

d) chemothera peutic a ction.

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txJ Antlsense animals are required for

a) clam and quite animals

b) drug action evaluation

x) Antisense therapy is implanted by

2. Briefly discuss antipsychotic drugs.