0044B00 Div.

01 sds Ethyl acetate SAFETY DATA SHEET IDENTIFICATION Ethyl acetate 141-78-6 205-500-4

GHS format

Section 1: Product Name CAS RN EC# SYNONYMS OTHER LANGUAGES

Ethyl acetic ester, Ethyl ester, Ethyl ethanoate, Acetoxyethane De: Ethylacetat Es: Acetato de etilo Fr: Actate d'thyle Acetic acid ethyl ester, Ethyl acetate C4H8O2

SYSTEMATIC NAME MOLECULAR FORMULA STRUCTURAL FORMULA

H3C O
INGREDIENTS Chemical Ethyl acetate CAS 141-78-6

CH3

Purity approx.100%

unit w/v

PRODUCT USES It is used in production of pharmaceuticals and foods, for contact lenses, Photographic films & plates, synthetic flavoring, chemical intermediate, perfumes, in leather processing industry, printing industry, absorbents and adsorbents, adhesives and binding agents, cosmetics, coloring agents etc.

Jubilant Organosys Limited

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0044B00 Div.01 sds Ethyl acetate

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FACTORY & REGISTERED OFFICE: Jubilant Organosys Limited, Bhartiagram, Gajraula District: Jyotiba Phuley Nagar Uttar Pradesh-244223 , India PHONE NO: +91-5924-252353 unto 252360 Contact Department-Safety: Ext. 7424 FAX NO : 91-5924-252352

HEAD OFFICE: Jubilant Organosys Limited Plot 1-A, Sector 16-A, Institutional Area, Noida, Uttar Pradesh-201301 India. PHONE NO: +91-120-2516601 Contact department: EHS FAX NO : +91-120-2516834 Email: [email protected]

Medical and Transport Emergencies: +91-9997022412 (India) Logistics emergencies +91-120-4365441. (India) MANUFACTURING LOCATION: Village Nimbut, Rly Stn. Nira Distt. Pune 412 102 Maharashtra, India Tel: +91 2112 269155/67 Fax: +912112 268154 Section 2:

HAZARD IDENTIFICATION

GHS CLASSIFICATION Flammable Liquid: Category 2 Serious eye damage/eye irritant: Category 2B OVERVIEW Yellow liquid with a characteristic smell. It is highly flammable and water-soluble. It is irritating to mucous surfaces, particularly the eyes, gums and respiratory passages. On repeated or prolonged exposures, it causes conjunctival irritation and corneal clouding. It is moderately toxic by intraperitoneal and subcutaneous routes. Repeated exposure may cause skin dryness or cracking. Vapors may cause drowsiness or dizziness. Not considered as dangerous to the environment. Ethyl acetate is a volatile solvent (VOC) but not a hazardous air pollutant (HAP). Danger! Highly flammable liquid and vapor. Causes eye irritation. PRECAUTIONARY STATEMENTS Prevention Keep container tightly closed. Keep away from ignition sources such as heat/sparks/open flame No smoking.

Jubilant Organosys Limited

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0044B00 Div.01 sds Ethyl acetate

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Wear protective gloves/clothing and eye/face protection. Use explosion-proof electrical/ventilating/ lighting/equipment. Take precautionary measures against static discharge. Use only non-sparking tools. Do not eat, drink or smoke when using this product. Wash hands thoroughly after handling. Use only outdoors or in a well-ventilated area.

Response In case of fire, use appropriate media as specified by the manufacturer for extinction. If On Skin (Or Hair): Remove/take off immediately all contaminated clothing. Rinse skin with water/shower. Immediately call a doctor or poison center in all incidents. If on Skin: Immediately take off all contaminated clothing. Wash thoroughly with water for at least 15 minutes. Wash contaminated clothes before reuse. If on Eyes: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do so. If eye irritation persists call a doctor. Ingestion: Rinse mouth. If swallowed do NOT induce vomiting. Wash hands after handling. Inhalation: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a physician if you feel unwell. Absorb spillage to prevent material damage. Storage Store locked up Store in a corrosive resistant container. Store in a cool well-ventilated place. Disposal Dispose of the container as per local norms and regulations. NFPA RATING HEALTH: 2 FLAMMABILITY: 3 REACTIVITY: 1 Section 3: Composition of ingredients

Sr.No. 1

Chemical Ethyl acetate

CAS # 141-78-6

EC# 205-500-4

Purity ~ 100%

Section 4:

First Aid Measures

Jubilant Organosys Limited

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0044B00 Div.01 sds Ethyl acetate

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Key symptoms Acute effects: Inhalation results in drowsiness, cough, nausea and headache. Skin exposure can lead to dry skin. Eye exposure can lead to redness and possible irritation. Chronic effects: After skin contact: Degreasing effect on the skin possibly followed by secondary inflammation. After long-term exposure to the chemical: Sensitisation with allergic manifestations have been reported.

FIRST AID: Eyes: If in eyes rinse cautiously with water for at least 15 minutes. Remove contact lenses if easy to do so. Continue rinsing. Seek medical attention. Skin: Immediately take off all contaminated clothing. Wash thoroughly with water for at least 15 minutes. Wash contaminated clothes before reuse. Seek immediate medical attention. Inhalation: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a physician if you feel unwell. Ingestion: If swallowed call a poison center if you feel unwell. Rinse mouth. Do NOT induce vomiting by use of emetics. Seek medical attention. Section 5:

Fire Fighting Measures

Flammable Liquid: Category 2 Flash point: -40C (24.80F). UEL: 11.5 %v/v; LEL: 2.2 %v/v; Auto ignition temperature: 425C (797F) Extinguishing media Dry chemical powder, carbon dioxide and alcohol resistant foam. Avoid using water. In very large fires one may use water spray, fog or alcohol-resistant foam by directing streams to the periphery of the fires to prevent spread. Special Protective Equipment And Precautions For Fire Fighter. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Keep the containers cool by spraying water if exposed to heat or fire. Move containers out of hazard area if safe to do so. Unusual fire and explosion hazard: Flashback along vapor trail may occur. Closed container exposed to heat may explode. Contact with strong oxidizer may cause fire. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out Jubilant Organosys Limited Page 4 of 12

0044B00 Div.01 sds Ethyl acetate

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Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. Section 6:

Accidental Release Measures

Minor Spills Clean up all spills immediately following relevant Standard Operating Procedures. Avoid breathing vapors and contact with skin and eyes. Shut off leak source if possible. Shut off all possible sources of ignition. Wipe up. Decontaminate all equipment. Use non-sparking tools. Major Spill Alert Emergency Responders and tell them location and nature of hazard. Shut off all possible sources of ignition and increase ventilation. Wear protective clothing, full boots, impervious gloves, safety glasses and Self Contained Breathing Apparatus (SCBA), as may be deemed appropriate. Stop leaks if possible. Prevent, by any means available, spillage from entering drains or water and watercourses. Collect recoverable product into labeled containers for recycling, recovery or disposal. Contain spill with sand, earth or vermiculite. Spread area with lime or absorbent material, and leave for at least 1 hour before washing. Clean up all tools and equipment. Inform authorities in event of contamination of any public sewers, drains or water bodies.

Section 7:

Handling & Storage

Jubilant Organosys Limited

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0044B00 Div.01 sds Ethyl acetate Handling

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Do not breathe vapor or mist. Wear protective gloves/clothing and eye/face protection. Wash thoroughly after handling. Ground and secure containers when dispensing or pouring product. Avoid contact with incompatible materials. When handling, DO NOT eat, drink or smoke. Launder contaminated clothing before re-use. If on skin or hair, IMMEDIATELY remove all contaminated clothing and rinse/shower with plenty of water. Use in a well ventilated place/Use protective clothing commensurate with exposure levels. Store in a cool, well ventilated place Store in a flame proof area Store away from incompatible materials. Keep only in original container. Keep securely closed when not in use.

Storage

Section 8:

Exposure Controls/Personal Protection

Exposure Limits NIOSH REL: TWA 400 ppm (1400 mg/m3) OSHA PEL: TWA 400 ppm (1400 mg/m3) ACGIH 1997: TLV: 400 ppm; 1440 mg/m3 IDLH 2000 ppm OEL-AUSTRALIA: TWA 400 ppm (1400 mg/m3) OEL-THE PHILIPPINES: TWA 400 ppm (1400mg/m3) NDS POLAND: 200 mg/m3 Exposure Controls Provide exhaust ventilation or other engineering controls to keep the relevant airborne concentrations below their respective occupational exposure limits. Local ventilation is usually preferred. Ensure that eyewash stations and safety showers are close to the workstation location. Personal Protection: Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier. Hands: Wear appropriate protective gloves to prevent skin exposure. Eyes: Safety goggles/ Chemical Safety glasses and Face shield. Clothing: Boots and clothing to prevent contact. Jubilant Organosys Limited Page 6 of 12

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Respirator: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. General Hygiene and general comments: Wash hands and face after working with substance. Immediately change contaminated clothing. Apply skin protective barrier cream.

Jubilant Organosys Limited

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0044B00 Div.01 sds Ethyl acetate Section 9: Sr.No. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 17 18 19 20 21 22 23 24 Physical and Chemical Properties

GHS format

Parameter Appearance Odor Odor Threshold Melting point Boiling point Flash point Evaporation rate (n-BuAc=1) Explosive limits Vapor pressure Vapor density (air=1) Relative density Specific gravity (water=1) Solubility pH Log Pow (octonol/water) Auto-ignition temperature Decomposition temperature Viscosity Molecular Weight pKa (@250C) Koc Flammable material Oxidizer Corrosive material Explosive material Section 10: Stability and Reactivity

Typical value Colourless liquid Ether like fruity odour 0.96 - 176.9 ppm (-) 84C 77.15 C (-) 4.4 C, closed cup 4.2 2.1%-11.5% 124.79 hPa at 20 C Not available 0.902@ 20 C 0.902 83g/l at 20C; 80g/l at 25C Not available 0.60 427C Not available 0.44 Pas @25 C 88.11 Not available 8.8 Yes No No No

Stability: Stable under normal temperature and pressure. Heat will contribute to instability. Conditions to avoid: Avoid heat, flame and other sources of ignition. Contact with nitrates, strong oxidizers, strong alkalis, or strong acids may cause fire and explosions. Will attack some forms of plastic, rubber, and coatings. Incompatible chemicals: Strong acids, strong oxidizing agents and strong bases. Hazardous decomposition: Thermal decomposition may produce carbon monoxide, carbon dioxide, acetic acid, and ethyl alcohol. Hazardous Polymerization: Not reported.

Jubilant Organosys Limited

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0044B00 Div.01 sds Ethyl acetate Section 11: Toxicological Information

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ACUTE STUDIES: It is irritating to mucous surfaces, particularly the eyes, gums and respiratory passages. . It is moderately toxic by intraperitoneal and subcutaneous routes. Skin exposure can lead to dry skin. Vapors may cause drowsiness or dizziness. Not considered as dangerous to the environment. RTECS#: AH5425000 ACUTE ORAL LD50 (Rat) ACUTE DERMAL LD50:(Rabbit) ACUTE INHALATION LC50:

= 5620 mg/kg = > 20 mL/kg = 200000mg/m3

CHRONIC STUDIES: After skin contact: Degreasing effect on the skin possibly followed by secondary inflammation. After long-term exposure to the chemical: Sensitisation with allergic manifestations has been reported. TARGET ORGANS: Eyes, skin, respiratory system, CNS, liver and blood. CARCINOGENICITY Not listed by NTP, IARC and OSHA. Not present on the EU CMR list. According to information presently available Ethyl acetate is not found to be carcinogenic. CHRONIC EXPOSURE - MUTAGEN Species: Hamster Dose: 9 GM/L Cell Type: fibroblast Mutation test: Cytogenetic analysis Section 12: Ecological Information

Ecotoxicity: Aquatic LC50 (48h) Leuciscus idus melanotus (fish, fresh water) = 270-333 mg/L Aquatic LC50 (96h) oncorhyncus mykiss (fish, fresh water) = 484 mg/L Aquatic EC50 (24h) Artemia Salina (Crustacea) = 644.8 mg/L Aquatic EC50 (48h) Daphnia Cucullata (Crustacea) = 164mg/L Aquatic EC50 (48h) Scenedesmus subspicatus (Algae) = 3300mg/L Aquatic EC50 (15min) Photobacterium Phosphoreum (Bacteria) = 5870mg/L Chronic Toxicity to Fish Aquatic LOEC (32days) Pimephales Promelas (fish, fresh water) = 9.65mg/L

Jubilant Organosys Limited

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0044B00 Div.01 sds Ethyl acetate (Embryo Larval test)

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Environmental Fate: Koc=8.8. If released on land, Ethyl acetate will be lost by evaporation and leaching into groundwater. Biodegradation should also occur. It is very soluble in water and is not expected to absorb significantly to soil. Because of its high vapor pressure and low adsorption to soil, ethyl acetate would be expected to volatilize rapidly from soil and other surfaces. Solubility In Water: 83g/l at 200 C. This product is lighter than water and will float on the surface. The product is poorly absorbed onto soils or sediments. Henrys Law constant: 1.5 10E-4 atm-m3/mole. From Henrys Law constant one can calculate a half-life for volatilization from a river 1 m deep with a 1 m /sec current and 3 m/sec wind of 10.1 hour. Diffusions through the liquid and the vapor phase are an important element in the volatilization process so changes in current and wind will affect the rate. Log Pow =0.6. This chemical is not likely to bioconcentrate. It undergoes rapid biodegradation. Substance is biodegradable with low possibility of bioaccumulation. Section 13:

Disposal Consideration

US EPA Waste Number: U112 (Ignitable waste, USA) Burn in a chemical incinerator equipped with an afterburner and scrubber. Exert extra care in igniting, as this material is highly flammable. Dispose of this material in accordance with standard practice for disposal of potentially hazardous materials as required by applicable federal, state or local laws. Note that disposal regulations may also apply to empty containers and equipment rinsates.

Section 14:

Transport Information

This substance is considered to be hazardous for transport by Air/Rail/Road and Sea and thus regulated by IMO/ IMDG/ IATA/ ICAO. S.No Agency UN Number UN 1173
ADR/RID

Land transport

Proper Shipping name Ethyl acetate

Hazard Class Packing Group 3 Flammable liquid.

Jubilant Organosys Limited

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0044B00 Div.01 sds Ethyl acetate Maritime Transport Air Transport UN 1173 IMDG UN 1173 IATA Ethyl acetate Ethyl acetate

GHS format 3 Flammable liquid. 3 Flammable liquid.

II II

Hazard Label

Section 15:

Regulatory Information

European information EC# 205-500-4 Classification: R11 - Xi; R36 - R66 - R67 Xi Irritant RISK PHRASES R11 Highly flammable. R36 Irritating to eyes. R66 Repeated exposure may cause skin dryness or cracking. R67 Vapors may cause drowsiness and dizziness. SAFETY PHRASES S16 S 26 S33 Keep away from sources of ignition -- No smoking. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Take precautionary measures against static discharges.

Pre-Registration Status under REACH Regulation (EC) No. 1907/2006

EC Name

Submission Number YW194220-03

Pre-registration Number 05-2114365825-39-0000

Ethyl acetate

Name of the Organization (OR) Jubilant Pharmaceuticals NV

Validity

30/11/2010

US information Is listed in EPA TSCA chemical inventory. CERCLA Section 103 ((40CFR302.4): 5000 LBS RQ Page 11 of 12

Jubilant Organosys Limited

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None of the chemicals in this product have an TPQ under SARA Section 302 TPQ None of the chemicals in this product are reported under SARA Section 313 None of the chemicals in this product contain any class1 & class2 ozone depletors, neither contain any hazardous air pollutants under Clean Air Act None of the chemicals in this product are listed as Hazardous substances or priority pollutants or Toxic substances list under Clean Water Act NFPA Code: H1; F3; R0 Transport Emergency Card: TEC (R)-76

CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR. DSL: Yes NDSL: No Section 16: Other Information

SDS data Chemical: Ethyl acetate CAS #: 141-78-6 File Name: 0044B01 Div.01 sds Ethyl acetate Date: December 10, 2008 Revision Number: 01 Information contained in this SDS is believed to be correct but no representation, guarantee or warranties of any kind are made as to its accuracy, suitability for a particular application or results to be obtained from them. This SDS shall be used as a guide only. JUBILANT ORGANOSYS LIMITED makes no warranties expressed or implied of the adequacy of this document for any particular purpose.

Jubilant Organosys Limited

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