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    AmbioDisk Information

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    nurani atikasari
    ClearifyTM processed amniotic membrane grafts retain the intermediate layer of the amniotic membrane which contains hyaluronic acid and growth factors that promote wound healing. The intermediate layer contains elements like hyaluronic acid, EGF, IL-4, IL-10, TGF-β, TGF-α, PDGF-AA, PDGF-BB, VEGF and TIMPs that are involved in processes like cell migration, proliferation, angiogenesis, inflammation reduction and extracellular matrix formation. Retaining the intermediate layer allows the grafts to better support treatment of ocular surface diseases and disorders like corneal ulcers through its wound healing properties.

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    AmbioDisk Information

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    nurani atikasari
    44 views2 pages
    ClearifyTM processed amniotic membrane grafts retain the intermediate layer of the amniotic membrane which contains hyaluronic acid and growth factors that promote wound healing. The intermediate layer contains elements like hyaluronic acid, EGF, IL-4, IL-10, TGF-β, TGF-α, PDGF-AA, PDGF-BB, VEGF and TIMPs that are involved in processes like cell migration, proliferation, angiogenesis, inflammation reduction and extracellular matrix formation. Retaining the intermediate layer allows the grafts to better support treatment of ocular surface diseases and disorders like corneal ulcers through its wound healing properties.

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    ClearifyTM processed amniotic membrane grafts retain the intermediate layer of the amniotic membrane which contains hyaluronic acid and growth factors that promote wound healing. The intermediate layer contains elements like hyaluronic acid, EGF, IL-4, IL-10, TGF-β, TGF-α, PDGF-AA, PDGF-BB, VEGF and TIMPs that are involved in processes like cell migration, proliferation, angiogenesis, inflammation reduction and extracellular matrix formation. Retaining the intermediate layer allows the grafts to better support treatment of ocular surface diseases and disorders like corneal ulcers through its wound healing properties.

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    © All Rights Reserved
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    44 views2 pages

    AmbioDisk Information

    Uploaded by

    nurani atikasari
    ClearifyTM processed amniotic membrane grafts retain the intermediate layer of the amniotic membrane which contains hyaluronic acid and growth factors that promote wound healing. The intermediate layer contains elements like hyaluronic acid, EGF, IL-4, IL-10, TGF-β, TGF-α, PDGF-AA, PDGF-BB, VEGF and TIMPs that are involved in processes like cell migration, proliferation, angiogenesis, inflammation reduction and extracellular matrix formation. Retaining the intermediate layer allows the grafts to better support treatment of ocular surface diseases and disorders like corneal ulcers through its wound healing properties.

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    of 2

    CLEARIFY™ PROCESSED

    OFFICE BASED AMNIOTIC MEMBRANE GRAFTS

    SOLUTIONS TO SUPPORT THE TREATMENT OF OCULAR


    SURFACE DISEASES AND DISORDERS
    Clinical applications:
    • Corneal ulcers
    • Neurotrophic ulcers
    • Recurrent corneal erosions
    • Chemical and thermal burns
    • Conditions associated with excessive dry eye

    MORE ROBUST BIOSTRUCTURE WITH HIGH PROTEIN


    CONTENT AND EXCELLENT HANDLING CHARACTERISTICS
    • Five-year shelf life with ambient, room-temperature storage
    • Clearify™ process now retains the intermediate layer of amniotic membrane
    • Multi-layer Ambio grafts retain more hyaluronic acid (HA) than previous generations

    PREVIOUS GENERATION CLEARIFYTM PROCESSED NEXT GEN.


    AMNIOTIC MEMBRANE LAYERS AMNIOTIC MEMBRANE LAYERS
    AmbioDisk® Multi-layer AmbioDisk® AmbioDisk® Multi-layer AmbioDisk®

    Amnion Amnion
    Amnion
    Amnion Intermediate
    Chorion Intermediate
    Chorion

    Ordering Information
    AD-5090 9mm AmbioDisk AD-5012 12mm AmbioDisk AD-5150 15mm AmbioDisk AF-1150 15mm AmbioDisk
    amnion & intermediate layer amnion & intermediate layer amnion & intermediate layer amnion, intermediate & chorion layer

    Clearify™ is a trademark of StimLabs LLC


    AmbioDisk® is a registered trademark of Katena Products
    DEHYDRATED NOT DENATURED

    The Clearify™ process now retains the intermediate layer of the amniotic membrane. Multi-layer, Ambio5® grafts
    retain more hyaluronic acid (HA) than previous generations.

    ESSENTIAL ELEMENTS PRESENT IN THE INTERMEDIATE LAYER


    The intermediate layer of amniotic membrane tissue contains detectable levels of the following essential elements
    HA EGF IL-4 IL-10 TGF- β TGF-a PDGF-AA PDGF-BB VEGF TIMP-1 TIMP-2 TIMP-4
    4 4 4 4 4 4 4 4 4 4 4 4

    Description of the regulatory components found in the intermediate layer and the function
    these components perform in utero.
    4 Hyaluronic acid (HA)
    Involved in cell migration and the proliferation of fibroblasts. Plays a role in the
    regulation of the inflammatory response and assists in tissue hydration.
    • HA is naturally found in the eyes and often used during eye surgery to reduce
    inflammation and speed wound healing.1,2,3

    4 Epidermal Growth Factor (EGF)


    Plays an important role in epithelialization, attracts endothelial cells and fibroblasts
    and helps regulate angiogenesis and tissue integrity.
    4 Interleukin-4 (IL- 4)
    Involved in regulating and decreasing inflammation. Plays a role in the synthesis
    of new extracellular matrix.
    4 Interleukin-10 (IL-10)
    Plays a role in downregulating the inflammatory response and the expression of
    inflammatory cytokines, such as IL-6 and TNFa.
    4 Transforming Growth Factor β (TGF-β)
    Active in epithelialization, matrix formation and tissue remodeling. Involved in
    angiogenesis and the maintenance of the normal phenotype of corneal keratinocytes.
    4 Transforming Growth Factor α (TGF- α)
    Stimulates migration and proliferation of epithelial cells and keratinocytes and helps
    maintain epithelialization of a wound.
    4 Platelet Derived Growth Factor AA (PDGF-AA)/Platelet Derived Growth Factor BB (PDGF-BB)
    Have been shown to stimulate the production of collagen and glycosaminoglycans
    by fibroblasts, and thereby may play an important role in the wound repair process.
    Attract neutrophils to wound site to remove contaminating bacteria.

    4 Vascular endothelial growth factor (VEGF)


    Assists wound healing by stimulating the process of forming new blood vessels
    known as angiogenesis.

    4 Basic Fibroblast Growth Factor (bFGF)


    Regulator of fibroblast and epithelial cell migration and assists in angiogenesis.
    4 Tissue Inhibitors of Metalloproteinases 1, 2, 4 (TIMP-1, TIMP-2, and TIMP-4)
    Help reulate extracellular matrix integrity and inhibit angiogenesis. Inhibits matrix
    metalloproteinases which are elevated in patients with dry eye and have been
    found in the tears of those patients with recurrent corneal erosions.
    1.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1772195/#r4
    2.https://www.ncbi.nlm.nih.gov/pubmed/26978861
    3.https://www.ncbi.nlm.nih.gov/pubmed/25039417

    800-225-1195 • www.katena.com ®

    KB-SS-072219-Rev0 800-225-1195 • www.katena.com

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