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    DMD 2

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    This document summarizes 3 studies on the effects of different types of aerobic exercise on boys with Duchenne muscular dystrophy (DMD). Study 1 was a pilot randomized controlled trial comparing aquatic therapy plus land exercises to land exercises alone. Study 2 compared the effects of bicycle ergometer training versus treadmill training on functional walking capacity and balance when combined with physical therapy. Study 3 was a randomized controlled trial comparing 24 weeks of assisted bicycle training of the legs and arms to usual care on functional deterioration in boys with DMD. The studies found that aquatic therapy, treadmill training, and assisted bicycle training may help to delay functional decline compared to other exercises or usual care for boys with DMD.

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    DMD 2

    Uploaded by

    pkhqkgqm85
    8 views4 pages
    This document summarizes 3 studies on the effects of different types of aerobic exercise on boys with Duchenne muscular dystrophy (DMD). Study 1 was a pilot randomized controlled trial comparing aquatic therapy plus land exercises to land exercises alone. Study 2 compared the effects of bicycle ergometer training versus treadmill training on functional walking capacity and balance when combined with physical therapy. Study 3 was a randomized controlled trial comparing 24 weeks of assisted bicycle training of the legs and arms to usual care on functional deterioration in boys with DMD. The studies found that aquatic therapy, treadmill training, and assisted bicycle training may help to delay functional decline compared to other exercises or usual care for boys with DMD.

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    This document summarizes 3 studies on the effects of different types of aerobic exercise on boys with Duchenne muscular dystrophy (DMD). Study 1 was a pilot randomized controlled trial comparing aquatic therapy plus land exercises to land exercises alone. Study 2 compared the effects of bicycle ergometer training versus treadmill training on functional walking capacity and balance when combined with physical therapy. Study 3 was a randomized controlled trial comparing 24 weeks of assisted bicycle training of the legs and arms to usual care on functional deterioration in boys with DMD. The studies found that aquatic therapy, treadmill training, and assisted bicycle training may help to delay functional decline compared to other exercises or usual care for boys with DMD.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    8 views4 pages

    DMD 2

    Uploaded by

    pkhqkgqm85
    This document summarizes 3 studies on the effects of different types of aerobic exercise on boys with Duchenne muscular dystrophy (DMD). Study 1 was a pilot randomized controlled trial comparing aquatic therapy plus land exercises to land exercises alone. Study 2 compared the effects of bicycle ergometer training versus treadmill training on functional walking capacity and balance when combined with physical therapy. Study 3 was a randomized controlled trial comparing 24 weeks of assisted bicycle training of the legs and arms to usual care on functional deterioration in boys with DMD. The studies found that aquatic therapy, treadmill training, and assisted bicycle training may help to delay functional decline compared to other exercises or usual care for boys with DMD.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 4

    Kingdom Of Saudi Arabia

    Al-Madinah Al-Munawara
    Ministry of Health Maternity and Children’s Hospital
    Medical Rehabilitation Dep. Physical Therapy

    Effect of aerobic exercise on


    Duchenne Muscular Dystrophy

    Done by:
    Ahdab Aljohani
    Arwa Al-johani
    Study 1:
    Aquatic therapy for boys with Duchenne muscular dystrophy (DMD): an
    external pilot randomized controlled trial

     P (Population):
    40 ambulatory boys aged from 7-16 years old with genetically confirmed
    DMD, North Star ambulatory assessment < 8

     I (Intervention):
    Standardised AT was prescribed and delivered by an AT- trained
    physiotherapist (with specialist knowledge of DMD), based on the study
    protocols detailed in a manual, in 30-min sessions twice weekly in an NHS
    pool with a temperature of 34–36 °C. Standardised LBT stretches and
    exercises were prescribed by a specialist physiotherapist at the baseline
    appointment, based on the study protocols detailed in a manual.

     C (Comparison):
    they were randomly allocated in a 1:1 ratio by a centralised web-based
    randomisation system provided by the Sheffield Clinical Trials Research Unit
    (CTRU) to AT plus land-based therapy (LBT) or LBT alone , the control group
    receive AT plus (LBT )
    Those randomised to receive AT were asked to perform LBT on four of the
    other 5 days of the week, while those in the control group were asked to
    perform LBT 6 days/week
     O (Outcome)
    Over 6 months, 348 boys were screened: most lived too far from centres or were
    enrolled in other trials; 12 (30% of the targets) were randomised to AT (n = 8) or
    control (n = 4). The mean change in NSAA at 6 months was −5.5 (SD 7.8) in the
    control arm and −2.8 (SD 4.1) in the AT arm. Harms included fatigue in two boys,
    pain in one. Physiotherapists and parents valued AT but believed it should be
    delivered in community settings. Randomisation was unattractive to families, who
    had already decided that AT was useful and who often preferred to enrol in drug
    studies. The AT prescription was considered to be optimised for three boys, with
    other boys given programmes that were too extensive and insufficiently focused.
    Recruitment was insufficient for VoI analysis.
     Study 2:
    Efficacy of two intervention approaches on functional walking capacity and
    balance in children with Duchene muscular dystrophy
     P (Population):
    Thirty ambulatory boys aged from 6-10 years were diagnosed with DMD, having
    grade 3+ muscle strength in lower limbs and trunk muscles and having a
    functional ROM for UL and LL joints.
     I (Intervention):
    Group A: 15 Children were trained on the bicycle ergometer for 20 min, at three times a
    week for three successive months. Group B: 15 children underwent treadmill training for
    20 minutes. Both groups received a PT program 3x/ week.
    The program included gentle stretching for (biceps brachii, hamstrings, and calf muscles).
    Isometric for (quadriceps, hamstrings, anterior tibial group, calf muscles, biceps and
    triceps). Every contraction was held and relaxed for 5, 5 reps.

     C (Comparison): The study aimed to compare the effects of a bicycle ergometer


    vs a treadmill on functional walking capacity and balance in DMD.
     O (Outcome): Biodex balance system equipment and (6MWT).
    The results indicated that treadmill training produced significant improvement in
    functional walking capacity and balance compared with bicycle ergometer training.

    Reference: Sherief, A. E. A. A., Abd ElAziz, H. G., & Ali, M. S. (2021). Efficacy of two intervention approaches on functional walking
    capacity and balance in children with Duchene muscular dystrophy. Journal of musculoskeletal & neuronal interactions, 21(3), 343–350.
    Study 3:
    Assisted Bicycle Training Delays Functional Deterioration in Boys With Duchenne
    Muscular Dystrophy: The Randomised Controlled Trial “No Use Is Disuse”
     P (Population): the study population age < 6 and Boys were eligible if
    they were in their late ambulatory phase and showed a labored gait and/or had
    difficulties with rising from the floor. Boys were included if they needed more
    than 5 seconds to rise from the floor, were not able to rise from the floor, were not
    able to cycle without electric assistance, or needed a wheelchair to move over a
    long (>500 m) distance. Wheelchair-dependent boys were eligible if they were
    able to touch the top of their head with both hands or were able to use a hand-
    operated wheelchair
     I (Intervention): the intervention was assisted bicycle training of the legs and
    arms during 24 weeks.
     C (Comparison): a 2:1 ratio the the control group received usual care during
    24 weeks. Usual care means that boys were allowed to continue their activities,
    including physiotherapy, but they did not receive any specific intervention. The
    control group received the same training after the 24-week waiting period. The
    intervention and control groups were followed up until 56 and 60 weeks after
    study entry
     O (Outcome):

    The results suggest that assisted bicycle training of the legs and arms is feasible
    and safe for both ambulant and wheelchair-dependent children and may decline
    the deterioration due to disuse. Progressive deterioration, however, may
    compromise the design of trials for DMD.

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