Sys Master - Pdfs - Hfa - HCF - 10574924939294 - SDS - DRE C15089000 - ST WB MSDS 5275250 1 1 1

SAFETY DATA SHEET
This safety data sheet was created pursuant to the requirements of:
Regulation (EC) No. 1907/2006 and Regulation (EC) No. 1272/2008
Revision date 14-Sep-2021 Revision Number 1
SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier
Product Code(s) DRE-C15089000
Product Name 2-Methyl-4-isothiazolin-3-one
Form Not applicable
NOTE [8] - No registration number is given for this substance because it is under the threshold in REACH Article
6(1) and not subject to the registration requirements according to REACH Title II
EC No (EU Index No) 220-239-6
CAS No 2682-20-4
Chemical name 2-Methyl-4-isothiazolin-3-one(MI)
Pure substance/mixture Substance
Formula C4H5NOS
Molecular weight 115.16
1.2. Relevant identified uses of the substance or mixture and uses advised against
Recommended use Laboratory use
Uses advised against No information available
1.3. Details of the supplier of the safety data sheet
Supplier
LGC Limited
Queens Road
Teddington
Middlesex TW11 0LY
UNITED KINGDOM
:+44 (0) 20 8943 7000
Fax :+44 (0) 20 8943 2767
eMail : [email protected]
Web : www.lgcstandards.com
For further information, please contact
EGHS / EN Page 1 / 19
SAFETY DATA SHEET
DRE-C15089000 - 2-Methyl-4-isothiazolin-3-one
E-mail address [email protected]
1.4. Emergency telephone number
Emergency Telephone For Hazardous Materials or Dangerous Goods Incident

Spill, Leak, Fire Exposure, or Accident
Call CHEMTREC:
USA & Canada 1-800-424-9300
Rest of the world +1 703-741-5970
Emergency Telephone - §45 - (EC)1272/2008

Europe 112
Austria No information available
Bulgaria
Croatia
Cyprus
Czech Republic
Denmark
France
Hungary
Ireland
Italy
Lithuania
Luxembourg
Netherlands
Norway
Portugal
Romania
Slovakia
Slovenia
Spain
Sweden
Switzerland
SECTION 2: Hazards identification

2.1. Classification of the substance or mixture
Regulation (EC) No 1272/2008
Acute toxicity - Oral Category 3 - (H301)
Acute toxicity - Dermal Category 3 - (H311)
Acute toxicity - Inhalation (Dusts/Mists) Category 2 - (H330)
Skin corrosion/irritation Category 1 Sub-category B - (H314)
SAFETY DATA SHEET
Serious eye damage/eye irritation Category 1 - (H318)

Skin sensitisation Category 1A - (H317)
Acute aquatic toxicity Category 1 - (H400)
Chronic aquatic toxicity Category 1 - (H410)
2.2. Label elements
220-239-6
Contains 2-Methyl-4-isothiazolin-3-one(MI)
Signal word
Danger
Hazard statements
H301 - Toxic if swallowed
H311 - Toxic in contact with skin
H314 - Causes severe skin burns and eye damage
H317 - May cause an allergic skin reaction
H330 - Fatal if inhaled
H410 - Very toxic to aquatic life with long lasting effects
EUH071 - Corrosive to the respiratory tract
Precautionary Statements - EU (§28, 1272/2008)

P260 - Do not breathe dust/fume/gas/mist/vapours/spray
P273 - Avoid release to the environment
P280 - Wear protective gloves/protective clothing and eye/face protection
P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor
P391 - Collect spillage
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed
2.3. Other hazards
No information available.
This substance does not meet the PBT/vPvB criteria of REACH, annex XIII.
SAFETY DATA SHEET
This product does not contain any known or suspected endocrine disruptors.
Chemical name EU - REACH (1907/2006) - Article 59(1) EU - REACH (1907/2006) - Endocrine
- Candidate List of Substances of Very Disruptor Assessment List of
High Concern (SVHC) for Authorisation Substances
2-Methyl-4-isothiazolin-3-one(MI) - -
SECTION 3: Composition/information on ingredients

3.1 Substances
Chemical name Weight-% REACH registration EC No (EU Classification according Specific M-Factor M-Factor
number Index No) to Regulation (EC) No. concentration (long-term)
1272/2008 [CLP] limit (SCL)
2-Methyl-4-isothiazo 100 - (613-326-00 Acute Tox. 3 (H301) Skin Sens. 1A 10 1
lin-3-one(MI) -9) Acute Tox. 3 (H311) :: C>=0.0015%
2682-20-4 220-239-6 Acute Tox. 2 (H330)
Skin Corr. 1B (H314)
Eye Dam. 1 (H318)
Skin Sens. 1A (H317)
(EUH071)
Aquatic Acute 1 (H400)
Aquatic Chronic 1
(H410)
Full text of H- and EUH-phrases: see section 16
Acute Toxicity Estimate

If LD50/LC50 data is not available or does not correspond to the classification category, then the appropriate conversion
value from CLP Annex I, Table 3.1.2, is used to calculate the acute toxicity estimate (ATEmix) for classifying a mixture
based on its components
Chemical name Oral LD50 mg/kg Dermal LD50 Inhalation LC50 - 4 Inhalation LC50 - 4 Inhalation LC50 - 4
mg/kg hour - dust/mist - mg/L hour - vapour - mg/L hour - gas - ppm
2-Methyl-4-isothiazolin-3- 232 200 No data available No data available No data available
one(MI) 120
2682-20-4
This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC) No.
1907/2006 (REACH), Article 59)
SAFETY DATA SHEET
SECTION 4: First aid measures

4.1. Description of first aid measures
General advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is
required.
Inhalation If breathing has stopped, give artificial respiration. Get medical attention immediately.
Remove to fresh air. Do not breathe dust. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask
equipped with a one-way valve or other proper respiratory medical device. If breathing is
difficult, (trained personnel should) give oxygen. Delayed pulmonary edema may occur. Get
immediate medical advice/attention.
Eye contact Get immediate medical advice/attention. Rinse immediately with plenty of water, also under
the eyelids, for at least 15 minutes. Keep eye wide open while rinsing. Do not rub affected
area. Remove contact lenses, if present and easy to do. Continue rinsing.
Skin contact Get immediate medical advice/attention. Wash off immediately with soap and plenty of
water while removing all contaminated clothes and shoes. May cause an allergic skin
reaction.
Ingestion Do NOT induce vomiting. Rinse mouth. Never give anything by mouth to an unconscious
person. Get immediate medical advice/attention.
Self-protection of the first aider Ensure that medical personnel are aware of the material(s) involved, take precautions to
protect themselves and prevent spread of contamination. Do not breathe dust. Do not use
mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration
with the aid of a pocket mask equipped with a one-way valve or other proper respiratory
medical device. Use personal protective equipment as required. See section 8 for more
information. Avoid contact with skin, eyes or clothing.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms Coughing and/ or wheezing. Difficulty in breathing. Burning sensation. Itching. Rashes.
Hives.
4.3. Indication of any immediate medical attention and special treatment needed
Note to doctors Product is a corrosive material. Use of gastric lavage or emesis is contra-indicated. Possible
perforation of stomach or esophagus should be investigated. Do not give chemical
antidotes. Asphyxia from glottal edema may occur. Marked decrease in blood pressure may
occur with moist rales, frothy sputum, and high pulse pressure. May cause sensitisation in
susceptible persons. Treat symptomatically.
SAFETY DATA SHEET
SECTION 5: Firefighting measures

5.1. Extinguishing media
Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment.
Large Fire CAUTION: Use of water spray when fighting fire may be inefficient.
Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams.
5.2. Special hazards arising from the substance or mixture
Specific hazards arising from the The product causes burns of eyes, skin and mucous membranes. Thermal decomposition
chemical can lead to release of irritating gases and vapours. Product is or contains a sensitiser. May
cause sensitisation by skin contact.
5.3. Advice for firefighters
Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear.
precautions for fire-fighters Use personal protection equipment.
SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures
Personal precautions Avoid contact with skin, eyes or clothing. Ensure adequate ventilation. Use personal
protective equipment as required. Evacuate personnel to safe areas. Avoid generation of
dust. Do not breathe dust. Keep people away from and upwind of spill/leak. Attention!
Corrosive material.
Other information Refer to protective measures listed in Sections 7 and 8.
For emergency responders Use personal protection recommended in Section 8.
6.2. Environmental precautions
Environmental precautions Prevent further leakage or spillage if safe to do so. Should not be released into the
environment. Do not allow to enter into soil/subsoil. Prevent product from entering drains.
6.3. Methods and material for containment and cleaning up
Methods for containment Prevent further leakage or spillage if safe to do so.
Methods for cleaning up Take up mechanically, placing in appropriate containers for disposal.
SAFETY DATA SHEET
Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations.
6.4. Reference to other sections
Reference to other sections See section 8 for more information. See section 13 for more information.
SECTION 7: Handling and storage

7.1. Precautions for safe handling
Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact with
skin, eyes or clothing. Take off contaminated clothing and wash it before reuse. Do not
breathe dust. Avoid generation of dust. In case of insufficient ventilation, wear suitable
respiratory equipment. Handle product only in closed system or provide appropriate exhaust
ventilation. Do not eat, drink or smoke when using this product.
General hygiene considerations Remove and wash contaminated clothing and gloves, including the inside, before re-use.
Regular cleaning of equipment, work area and clothing is recommended. Wash hands
before breaks and immediately after handling the product. Do not breathe dust. Take off
contaminated clothing and wash it before reuse. Contaminated work clothing should not be
allowed out of the workplace. Avoid contact with skin, eyes or clothing. Do not eat, drink or
smoke when using this product. Wash hands before breaks and after work. Wear suitable
gloves and eye/face protection.
7.2. Conditions for safe storage, including any incompatibilities
Storage Conditions Keep containers tightly closed in a dry, cool and well-ventilated place. Keep out of the reach
of children. Store locked up. Protect from moisture. Store away from other materials. Please
refer to the manufacturer's certificate for specific storage and transport temperature
conditions. Store only in the original receptacle unless other advice is given on the CoA.
7.3. Specific end use(s)
Risk Management Methods (RMM) The information required is contained in this Safety Data Sheet.
SECTION 8: Exposure controls/personal protection

8.1. Control parameters
Exposure Limits
Chemical name European Union Austria Belgium Bulgaria Croatia
SAFETY DATA SHEET
2-Methyl-4-isothiazolin-3- - TWA: 0.05 mg/m3 - - -

one(MI) Skin sensitizer
2682-20-4
Chemical name France Germany Germany MAK Greece Hungary
2-Methyl-4-isothiazolin-3- - - TWA: 0.2 mg/m3 - -
one(MI) Peak: 0.4 mg/m3
2682-20-4 skin sensitizer
Chemical name Sweden Switzerland United Kingdom
2-Methyl-4-isothiazolin-3-one(MI - TWA: 0.2 mg/m3 -
) STEL: 0.4 mg/m3
2682-20-4
Biological occupational exposure limits

This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
regulatory bodies
Derived No Effect Level (DNEL) No information available.

Predicted No Effect Concentration No information available.
(PNEC)
8.2. Exposure controls
Personal protective equipment
Eye/face protection Tight sealing safety goggles. Face protection shield. Avoid contact with eyes. Wear safety
glasses with side shields (or goggles).
Hand protection Wear suitable gloves. Impervious gloves. The protective gloves to be used must comply
with the specifications of EC Directive 89/686/EEC and the related standard EN374.
Gloves
Duration of contact PPE - Glove material Glove thickness Break through time
Wear protective butyl
rubber gloves
Skin and body protection Long sleeved clothing. Chemical resistant apron. Wear suitable protective clothing.
Respiratory protection When workers are facing concentrations above the exposure limit they must use appropriate
certified respirators.
General hygiene considerations Remove and wash contaminated clothing and gloves, including the inside, before re-use.
SAFETY DATA SHEET
Regular cleaning of equipment, work area and clothing is recommended. Wash hands
before breaks and immediately after handling the product. Do not breathe dust. Take off
contaminated clothing and wash it before reuse. Contaminated work clothing should not be
allowed out of the workplace. Avoid contact with skin, eyes or clothing. Do not eat, drink or
smoke when using this product. Wash hands before breaks and after work. Wear suitable
gloves and eye/face protection.
Environmental exposure controls Do not allow into any sewer, on the ground or into any body of water.
SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties
Physical state Solid
Appearance Powder
Colour white
Odour No information available.
Odour threshold No information available
Property Values Remarks • Method

Melting point / freezing point 47.5 °C None known
Initial boiling point and boiling range130 °C None known
Flammability No data available None known
Flammability Limit in Air None known
Upper flammability or explosive No data available
limits
Lower flammability or explosive No data available
limits
Flash point No data available None known
Autoignition temperature No data available None known
Decomposition temperature None known
pH No data available None known
pH (as aqueous solution) 2.58 No information available
Kinematic viscosity No data available None known
Dynamic viscosity No data available None known
Water solubility 489 g/L None known
Solubility(ies) No data available None known
Partition coefficient -0.486 None known
Vapour pressure 0.007 hPa None known
Relative density 1.35 None known
Bulk density No data available
Liquid Density No data available
Relative vapour density No data available None known
Particle characteristics
Particle Size No information available
Particle Size Distribution No information available
SAFETY DATA SHEET
9.2. Other information

Molecular weight 115.16
Molecular formula C4H5NOS
9.2.1. Information with regards to physical hazard classes

Not applicable
9.2.2. Other safety characteristics

No information available
SECTION 10: Stability and reactivity

10.1. Reactivity
Reactivity No information available.
10.2. Chemical stability
Stability Stable under normal conditions.
Explosion data
Sensitivity to mechanical impact None.
Sensitivity to static discharge None.
10.3. Possibility of hazardous reactions
Possibility of hazardous reactions None under normal processing.
10.4. Conditions to avoid
Conditions to avoid Excessive heat. Exposure to air or moisture over prolonged periods.
10.5. Incompatible materials
Incompatible materials Acids. Bases. Oxidising agent.
Hazardous decomposition products None known based on information supplied.
SECTION 11: Toxicological information

11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008
Information on likely routes of exposure
SAFETY DATA SHEET
Product Information
Inhalation Specific test data for the substance or mixture is not available. Fatal if inhaled. (based on
components). Corrosive by inhalation. Inhalation of corrosive fumes/gases may cause
coughing, choking, headache, dizziness, and weakness for several hours. Pulmonary
edema may occur with tightness in the chest, shortness of breath, bluish skin, decreased
blood pressure, and increased heart rate. Inhaled corrosive substances can lead to a toxic
edema of the lungs. Pulmonary edema can be fatal.
Eye contact Specific test data for the substance or mixture is not available. Causes serious eye damage.
(based on components). Corrosive to the eyes and may cause severe damage including
blindness. May cause irreversible damage to eyes.
Skin contact Specific test data for the substance or mixture is not available. Corrosive. (based on
components). Causes burns. May cause sensitisation by skin contact. Repeated or
prolonged skin contact may cause allergic reactions with susceptible persons. Toxic in
contact with skin.
Ingestion Specific test data for the substance or mixture is not available. Causes burns. (based on
components). Ingestion causes burns of the upper digestive and respiratory tracts. May
cause severe burning pain in the mouth and stomach with vomiting and diarrhea of dark
blood. Blood pressure may decrease. Brownish or yellowish stains may be seen around the
mouth. Swelling of the throat may cause shortness of breath and choking. May cause lung
damage if swallowed. May be fatal if swallowed and enters airways.
Symptoms related to the physical, chemical and toxicological characteristics
Symptoms Coughing and/ or wheezing. Difficulty in breathing. Redness. Burning. May cause blindness.
Itching. Rashes. Hives.
Numerical measures of toxicity
Acute toxicity
Component Information
Chemical name Oral LD50 Dermal LD50 Inhalation LC50

2-Methyl-4-isothiazolin-3-one(MI 232 - 249 mg/kg ( Rat ) = 200 mg/kg ( Rabbit ) = 0.11 mg/L ( Rat ) 4 h
)
= 120 mg/kg ( Rat )
SAFETY DATA SHEET
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation Classification based on data available for ingredients. Causes burns.
Serious eye damage/eye irritation Classification based on data available for ingredients. Risk of serious damage to eyes.
Causes burns.
Respiratory or skin sensitisation May cause sensitisation by skin contact.
Germ cell mutagenicity No information available.
Carcinogenicity No information available.
Reproductive toxicity No information available.
STOT - single exposure No information available.
STOT - repeated exposure No information available.
Aspiration hazard No information available.
11.2. Information on other hazards
11.2.1. Endocrine disrupting properties
Endocrine disrupting properties No information available.
11.2.2. Other information
Other adverse effects No information available.
SECTION 12: Ecological information

12.1. Toxicity
SAFETY DATA SHEET
Ecotoxicity Very toxic to aquatic life with long lasting effects.
12.2. Persistence and degradability
Persistence and degradability No information available.
12.3. Bioaccumulative potential
Bioaccumulation There is no data for this product.
Component Information
Chemical name Partition coefficient
2-Methyl-4-isothiazolin-3-one(MI) -0.486
12.4. Mobility in soil
Mobility in soil No information available.
12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment
Chemical name PBT and vPvB assessment

2-Methyl-4-isothiazolin-3-one(MI) The substance is not PBT / vPvB
12.6. Endocrine disrupting properties
Endocrine disrupting properties No information available.
12.7. Other adverse effects

No information available.
SECTION 13: Disposal considerations

13.1. Waste treatment methods
Waste from residues/unused Dispose of in accordance with local regulations. Dispose of waste in accordance with
products environmental legislation.
Contaminated packaging Do not reuse empty containers.
SAFETY DATA SHEET
SECTION 14: Transport information

IATA
14.1 UN number or ID number UN2928
14.2 UN proper shipping name Toxic solid, corrosive, organic, n.o.s. (2-Methyl-4-isothiazolin-3-one(MI))
14.3 Transport hazard class(es) 6.1
Subsidiary hazard class 8
14.4 Packing group II
Description UN2928, Toxic solid, corrosive, organic, n.o.s. (2-Methyl-4-isothiazolin-3-one(MI)), 6.1 (8),
II
14.5 Environmental hazards Yes
14.6 Special precautions for user
Special Provisions A5
ERG Code 6C
IMDG
II, Marine pollutant
14.5 Marine pollutant P
Environmental hazards Yes
Special Provisions 274
EmS-No. F-A, S-B No information available
14.7 Maritime transport in bulk No information available
according to IMO instruments
RID
II, Environmentally Hazardous
Classification code TC2
ADR
SAFETY DATA SHEET
II, (D/E), Environmentally Hazardous
Classification code TC2
Tunnel restriction code (D/E)
SECTION 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
Water hazard class (WGK) strongly hazardous to water (WGK 3)
Poland SDS created according to the following Polish regulation: Act of February 25, 2011 on
chemical substances and their mixtures (Journal of Laws of 2018, item 143, as
amended). Regulation (EC) No 1907/2006 of the European Parliament and of the
Council on the Registration, Evaluation, Authorization and Restriction of Chemicals
(REACH), establishing the European Chemicals Agency (EC) as amended. Regulation
(EC) No 1272/2008 of the European Parliament and of the Council of 16 December
2008 on classification, labeling and packaging of substances and mixtures, as
amended. Regulation of the Minister of Health of 10 August 2012 on the criteria and
method of classifying chemical substances and their mixtures (Journal of Laws of
2012, item 1018). Regulation of the Minister of Health of 20 April 2012 on labeling
packaging of hazardous substances and mixtures and some mixtures (Journal of
Laws of 2012, item 445). Regulation of the Minister of Family, Labor and Social Policy
of 12 June 2018 on the maximum allowable concentrations and intensities of factors
harmful to health in the work environment (Journal of Laws of 2018, item 1286).
Announcement of the Minister of Economy, Labor and Social Policy of August 28,
2003 on the publication of the unified text of the Ordinance of the Minister of Labor
and Social Policy on general health and safety at work regulations (Journal of Laws
of 2003, No. 169, item 1650) . Regulation of the Minister of Health of 30 December
2004 on occupational safety and health related to the presence of chemical agents in
the workplace (Journal of Laws of 2005, No. 11, item 86). Act of December 14, 2012 on
waste (Journal of Laws of 2013, item 21) Regulation of the Minister of Health of
December 30, 2004 on occupational health and safety related to the presence of
chemical agents in the workplace (Journal U. of 2005, No. 11, item 86). Waste Act of
December 14, 2012 (Journal of Laws of 2013, item 21). Act of 13 June 2013 on the
SAFETY DATA SHEET
management of packaging and packaging waste, Journal of Laws 2013, item 888).
Government statement of September 24, 2002 - European Agreement on the
International Carriage of Dangerous Goods by Road (ADR) (Journal of Laws No. 194,
item 1629 and Journal of Laws of 2003, No. 207, item 2013 and 2014).
European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents
at work.
Authorisations and/or restrictions on use:

This product does not contain substances subject to authorisation (Regulation (EC) No. 1907/2006 (REACH), Annex XIV) This
product does not contain substances subject to restriction (Regulation (EC) No. 1907/2006 (REACH), Annex XVII)
DIRECTIVE (EU) 2021/1187 on the marketing and use of explosives precursors

Not applicable
Chemical name Restricted substance per REACH Substance subject to authorisation per
Annex XVII REACH Annex XIV
2-Methyl-4-isothiazolin-3-one(MI) - 2682-20-4 75.
Persistent Organic Pollutants

Not applicable
Dangerous substance category per Seveso Directive (2012/18/EU)

H2 - ACUTE TOXIC
E1 - Hazardous to the Aquatic Environment in Category Acute 1 or Chronic 1
Ozone-depleting substances (ODS) regulation (EC) 1005/2009

Not applicable
Chemical name Biocidal Products Regulation (EU) No 528/2012 (BPR)

2-Methyl-4-isothiazolin-3-one(MI) - 2682-20-4 Product-type 6: Preservatives for products during storage
International Inventories
TSCA Complies
DSL/NDSL Contact supplier for inventory compliance status
EINECS/ELINCS Contact supplier for inventory compliance status
ENCS Contact supplier for inventory compliance status
IECSC Contact supplier for inventory compliance status
KECL Contact supplier for inventory compliance status
PICCS Contact supplier for inventory compliance status
AIIC Contact supplier for inventory compliance status
SAFETY DATA SHEET
Legend:
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances
15.2. Chemical safety assessment
Chemical Safety Report A Chemical Safety Assessment has been carried out for this substance
SECTION 16: Other information

Key or legend to abbreviations and acronyms used in the safety data sheet
Full text of H-Statements referred to under section 3

EUH071 - Corrosive to the respiratory tract
H301 - Toxic if swallowed
H311 - Toxic in contact with skin
H314 - Causes severe skin burns and eye damage
H317 - May cause an allergic skin reaction
H318 - Causes serious eye damage
H330 - Fatal if inhaled
H400 - Very toxic to aquatic life
H410 - Very toxic to aquatic life with long lasting effects
Legend
SVHC: Substances of Very High Concern for Authorisation:
Legend Section 8: Exposure controls/personal protection

TWA TWA (time-weighted average) STEL STEL (Short Term Exposure Limit)
Ceiling Maximum limit value * Skin designation
Classification procedure
Classification according to Regulation (EC) No. 1272/2008 [CLP] Method Used
Acute oral toxicity Calculation method
Acute dermal toxicity Calculation method
Acute inhalation toxicity - gas Calculation method
Acute inhalation toxicity - Vapour Calculation method
SAFETY DATA SHEET
Acute inhalation toxicity - dust/mist Calculation method

Skin corrosion/irritation Calculation method
Serious eye damage/eye irritation Calculation method
Respiratory sensitisation Calculation method
Mutagenicity Calculation method
Carcinogenicity Calculation method
Reproductive toxicity Calculation method
STOT - single exposure Calculation method
STOT - repeated exposure Calculation method
Acute aquatic toxicity Calculation method
Chronic aquatic toxicity Calculation method
Aspiration hazard Calculation method
Ozone Calculation method
Key literature references and sources for data used to compile the SDS
Agency for Toxic Substances and Disease Registry (ATSDR)
U.S. Environmental Protection Agency ChemView Database
European Food Safety Authority (EFSA)
EPA (Environmental Protection Agency)
Acute Exposure Guideline Level(s) (AEGL(s))
U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act
U.S. Environmental Protection Agency High Production Volume Chemicals
Food Research Journal
Hazardous Substance Database
International Uniform Chemical Information Database (IUCLID)
Japan GHS Classification
Australian National Industrial Chemicals Notification and Assessment Scheme (NICNAS)
NIOSH (National Institute for Occupational Safety and Health)
National Library of Medicine's ChemID Plus (NLM CIP)
National Library of Medicine’s PubMed database (NLM PUBMED)
National Toxicology Program (NTP)
New Zealand's Chemical Classification and Information Database (CCID)
Organisation for Economic Co-operation and Development Environment, Health, and Safety Publications
Organisation for Economic Co-operation and Development High Production Volume Chemicals Programme
Organisation for Economic Co-operation and Development Screening Information Data Set
World Health Organization
Revision date 14-Sep-2021
This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006
Disclaimer
The information in this safety data sheet (SDS) has been prepared with due care and is true and accurate to the best of
our knowledge. The user must determine the suitability of the information for its particular purpose, ensure compliance
with existing laws and regulations, and be aware that other or additional safety or performance considerations may arise
when using, handling and/ or storing the material. The information in this SDS does not purport to be all inclusive or a
SAFETY DATA SHEET
guarantee as to the properties of the material supplied, and should be used only as a guide. LGC makes no warranties or
representations as to the accuracy and completeness of the information contained herein, shall not be held responsible
for the suitability of this information for the user's intended purposes or the consequences of such use, and shall not be
liable for any damage or loss, howsoever arising, direct or otherwise.
End of Safety Data Sheet

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SAFETY DATA SHEET

Revision date 14-Sep-2021 Revision Number 1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product Code(s) DRE-C15089000

Product Name 2-Methyl-4-isothiazolin-3-one

Form Not applicable

EC No (EU Index No) 220-239-6

Chemical name 2-Methyl-4-isothiazolin-3-one(MI)

Pure substance/mixture Substance

Molecular weight 115.16

Recommended use Laboratory use

Uses advised against No information available

1.3. Details of the supplier of the safety data sheet

For further information, please contact

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E-mail address [email protected]

1.4. Emergency telephone number

Emergency Telephone For Hazardous Materials or Dangerous Goods Incident

Emergency Telephone - §45 - (EC)1272/2008

SECTION 2: Hazards identification

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Serious eye damage/eye irritation Category 1 - (H318)

2.2. Label elements

Precautionary Statements - EU (§28, 1272/2008)

2.3. Other hazards

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SECTION 3: Composition/information on ingredients

Full text of H- and EUH-phrases: see section 16

Acute Toxicity Estimate

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SECTION 4: First aid measures

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SECTION 5: Firefighting measures

5.2. Special hazards arising from the substance or mixture

5.3. Advice for firefighters

SECTION 6: Accidental release measures

Other information Refer to protective measures listed in Sections 7 and 8.

For emergency responders Use personal protection recommended in Section 8.

6.2. Environmental precautions

6.3. Methods and material for containment and cleaning up

Methods for containment Prevent further leakage or spillage if safe to do so.

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6.4. Reference to other sections

SECTION 7: Handling and storage

7.2. Conditions for safe storage, including any incompatibilities

7.3. Specific end use(s)

SECTION 8: Exposure controls/personal protection

Chemical name European Union Austria Belgium Bulgaria Croatia

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2-Methyl-4-isothiazolin-3- - TWA: 0.05 mg/m3 - - -

Biological occupational exposure limits

Derived No Effect Level (DNEL) No information available.

8.2. Exposure controls

Personal protective equipment

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SECTION 9: Physical and chemical properties

Property Values Remarks • Method

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9.2. Other information