FORM – 1

WITH BASIC INFORMATION

FOR OBTAINING ENVIRONMENTAL CLEARANCE
OF
Proposed Synthetic Organic Chemicals
(API and Intermediate)
Manufacturing Project of

M/s. Chemcure Lifesciences LLP

Plot No.514/515/516, Bamanbore GIDC, Village- Bamanbore, Taluka-
Rajkot, District -Rajkot, Gujarat-360023

Prepared by :

T.R. Associates
A-401, S.G. Business Hub,
B/w Sola Bhagwat & Gota Over Bridge
Near Umiya Campus, S. G. Highway, Ahmedabad 380060
Contact No.: 98253 71099
Email: [email protected]

September 2020
 M/s. Chemcure Lifesciences LLP
Appendix – I
(See paragraph – 6)
FORM 1
(I) Basic Information
Name of the project : M/s. Chemcure lifesciences LLP
Location / Site alternative Plot No.514/515/516, Bamanbore GIDC, Village-
Bamanbore, Taluka- Rajkot, District -Rajkot, Gujarat-
under consideration
360023
Size of the Project* : Small Scale
Expected cost of the project : 6.0 crore (Annexure – 13)
Mr. Mohitkumar Kishorbhai Dedania –Partner
Contact Information :
(9687230287)
* Capacity corresponding to second activity (such as production capacity for
manufacturing, mining lease area and production capacity for mineral production, area
for mineral exploration, length for linear transport infrastructure, generation capacity for
power generation etc.)

Sr.
Item Details
No.
1. Name of the Project/s M/s. Chemcure lifesciences LLP
2. Sr. No. in the Schedule 5(f)
3. Proposed capacity/area/length/tonnage
to be handled/command area/lease area
/number of wells to be drilled
Type/
Production Category of
Sr. CAS No.
Name of the Product Capacity Product
No. (Product)
(MT/Month) (API/
Intermediate)
1 Olmesartan 144689-63-4 API
2 Benfotiamine 22457-89-2 API
3 Fluconazole 86386-73-4 API
4 Rabeprazole 117976-89-3 API
5 Pantoprazole 8 102625-70-7 API
6 Losartan potassium 124750-99-8 API
7 Itraconazole 84625-61-6 API
8 Pregabalin 148553-50-8 API
9 Levetriacetam 102767-28-2 API
10 Valproic acid 99-66-1 API
11 Clotrimazole 23593-75-1 API
12 Albandazole 54965-21-8 API
13 Chlorzoxazone 95-25-0 API
20
14 Oxyclozanide 2277-92-1 API
15 Diclofenac sodium 15307-86-5 API
16 Metformin 657-24-9 API
17 Niclosamide (vet.) 50-65-7 API

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 M/s. Chemcure Lifesciences LLP
18 Chlorpheniramine maleate 113-92-8 API
19 Naproxen sodium 26159-34-2 API
20 Phenyl butazone 50-33-9 API
4,6-Dichloro-2- 145783-15-9
21 (propylthio)pyrimidine-5- Intermediates
amine
22 BROMO-OTBN 114772-54-2 Intermediates
23 BCFI 83857-96-9 Intermediates
24 TTBB 124750-51-2 Intermediates
25 1-H IMIDAZOLE ESTER 144689-93-0 Intermediates
2-NITRO-4-THOICYNAO- 54029-45-7 Intermediates
26 ANILINE
2-CHLORO TRITYL 42074-68-0 Intermediates
27 CHLORIDE
L-VALINE METHYL ESTER 6306-52-1 Intermediates
28 .HCL
Bis(2-chloroethyl)amine 821-48-7 Intermediates
29 hydrochloride
2-(Diethylamino)ethyl 869-24-9 Intermediates
30 Chloride Hydrochloride
2-(Dimethylamino)ethyl 4584-46-7 Intermediates
31 chloride hydrochloride 40
3-(Dimethylamino)propyl 5407-04-5 Intermediates
32 chloride hydrochloride
4-(Aminomethyl) Benzoic 56-91-7 Intermediates
33 Acid
5-Difluoromethoxy-2- 102625-64-9 Intermediates
{[(3,4- dimethoxy-2-
34
pyridinyl)methyl]thio}-
1Hbenzimidazole
2-Chloromethyl 3,4- 72830-09-2 Intermediates
35
Dimethoxy Pyridine HCl
2-Chloromethoxy-4-(3- 153259-31-5 Intermediates
36 Methoxy Propoxy)-3-
Methyl Pyridine
2-[[[4-(3-Methoxy 117977-21-6 Intermediates
Propoxy)-3- Methyl
37
Pyridine-2-yl] Methyl]
Thio]-1H-Benzimidazole
38 Chloro acetyl Xylidine 1131-01-7 Intermediates
39 METHYL NICOTINATE 93-60-7 Intermediates
Total 68 MT/Month
40 R& D Product 0.5
Total 68.5 MT/Month
4. New/Expansion/Modernization New
5. Existing Capacity/Area etc. 3634.9 m2
6. Category of project i.e. “A” or “B” “B2”
7. Does it attract the general condition? If No
yes, please specify.
8. Does it attract the specific condition? If No, There is no SEZ, Export processing Zones,
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 M/s. Chemcure Lifesciences LLP
yes, please specify. Biotech parks, industrial estate, complex
9. Location
Plot/Survey/Khasra No. Plot No.514/515/516
Village Bamanbore
Tehsil Rajkot
District Rajkot
State Gujarat
Name of the applicant Mr. Mohitkumar Kishorbhai Dedania
10. Nearest railway station/airport along Rajkot : 27.9 Km in WSW direction
with distance in kms Rajkot : 29.8 Km in WSW direction
11. Nearest, city, District Headquarters Bamanbor : 2.9 Km in ENE direction.
along with distance in km
12. Village Panchayat, Zila Parishad, Bamanbor : 2.9 Km in ENE direction
Municipal Corporation, Local
body(complete postal) address with
telephone nos. to be given)
13. Name of the applicant Mr. Mohitkumar Kishorbhai Dedania
14. Registered Address Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023
15. Address for correspondence 186, Chitrakoot Dham, Behind Crystal Mall,
Kavlad Road, Rajkot.
Name Mr. Mohitkumar Kishorbhai Dedania
Designation(Owner/Partner/CEO) Partner
Address 186, Chitrakoot Dham, Behind Crystal Mall,
Kavlad Road, Rajkot.
Pin Code 360005
E-mail [email protected]
Telephone No. 9687230287
Fax No. Not Applicable
16. Details of Alternative sites examined, if No alternative site was selected.
any location of these sites should be
shown on a top sheet.
17. Interlinked Projects Not Applicable
18. Whether separate application of Not Applicable
interlinked project has been submitted
19. If yes, date of submission Not Applicable
20. If no, reason --
21. Whether the proposal involves approval Not Applicable
/clearance under:
(a) The Forest (Conservation)
Act,1980
(b) The Wildlife (Protection)

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 M/s. Chemcure Lifesciences LLP
Act,1972
(c) The C.R.Z Notification, 1991
22. Whether there is any Government Not Applicable
Order/ Policy relevant/ relating to the
site?
23. Forest land involved (hectares) Not Applicable
24. Whether there is any litigation pending Not Applicable
against the project and/or land in which
the project is propose to be set up
(a) Name of the court
(b) Case No.
(c) Orders/directions of the court, if
any and its relevance with the
proposed project.
(d) The following shall be inserted at
the end, namely :-

(II) Activity
1. Construction, operation or decommissioning of the Project involving actions, which
will cause physical changes in the locality (topography, land use, changes in water
bodies, etc.)

Yes Details thereof (with approximate

Sr. Information/Checklist
/No quantities / rates, wherever possible)
No. confirmation
with source of information data
1.1 Permanent or temporary change Yes It may be noted that the proposed project is
in land use, land cover or to be set-up on GIDC land.
topography including increase in There is minor change in land use due to
intensity of land use (with construction work.
respect to local and use plan)
1.2 Clearance of existing land, No Not Applicable
vegetation and buildings?
1.3 Creation of new land uses? No Not Applicable
1.4 Pre-construction investigations No Not Applicable
e.g. bore houses, soil testing?
1.5 Construction works? No Due to the construction activities like
excavation, construction material handling,
storage and construction waste disposal etc.
will bring very little changes to the site
topsoil. However, construction waste
generated will be inert in nature and same
will be collected, stored and utilized in filing

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 M/s. Chemcure Lifesciences LLP
of low lying areas. Therefore, there will be
minor changes in topography, landuse and
water bodies.
1.6 Demolition works? No Not Applicable
1.7 Temporary sites used for No No temporary sites or housing facilities will
construction works or housing of be provided since local contractors/
construction workers? workers will be given preference for various
construction activities.
1.8 Above ground buildings, Yes Key plan & Plant lay-out is attached as
structures or earthworks Annexure – 1 & 2
including linear structures, cut
and fill or excavations
1.9 Underground works including No Not Applicable
mining or tunneling?
1.10 Reclamation works? No Not Applicable
1.11 Dredging? No Not Applicable
1.12 Offshore structures? No Not Applicable
1.13 Production and manufacturing Yes Manufacturing process along with flow
processes? diagram is attached as Annexure – 4.
Adequate environment management system
will be provided in the plant.
Therefore, land use of the proposed project
site will not be impacted due to production
and manufacturing process.
1.14 Facilities for storage of goods or Yes Covered sheds with pucca flooring will be
materials? provided for storage of goods & materials
1.15 Facilities for treatment or Yes A detail of solid/hazardous waste is attached
disposal of solid waste or liquid as Annexure – 5
effluents? A detail of ETP is attached as Annexure –7
1.16 Facilities for long term housing of Yes Total 18 employees will be employed in
operational workers? proposed project site.
1.17 New road, rail or sea traffic No During operation phase, traffic will be
during construction or momentary increased. However; existing
operation? transport routes are adequate for the
proposed momentary increase in traffic.
1.18 New road, rail, air water borne or No Existing transportation facilities will be used
other transport infrastructure for the proposed project.
including new or altered routes
and stations, ports, airports etc.?
1.19 Closure or diversion of existing No Not Applicable
transport routes or infrastructure
leading to changes in traffic
movements?

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 M/s. Chemcure Lifesciences LLP
1.20 New or diverted transmission No Not Applicable
lines or pipelines?
1.21 Impoundment, damming, culver No Not Applicable
ting, realignment or other
changes to the hydrology of
watercourses or aquifers?
1.22 Stream crossings? No Not Applicable
1.23 Abstraction or transfers of water Yes Proposed water requirement is made
from ground or surface waters? through GIDC water supply.
1.24 Changes in water bodies or the No Not Applicable
land surface affecting drainage or
run-off?
1.25 Transport of personnel or No Transport of personnel or materials for
materials for construction, construction or operation will not bring
operation or decommissioning? change to topography, land use, water
bodies etc. Also to be noted that local
personnel will be employed for the
operation work, hence no such impact due to
transport of personnel or material is
envisaged.
1.26 Long-term dismantling or No Not Applicable
decommissioning or restoration
works?
1.27 Ongoing activity during No Not Applicable
decommissioning which could
have an impact on the
environment?
1.28 Influx of people to an area in No Local people will be given preference for
either temporarily or almost all the temporary as well as
permanently? permanent jobs. Therefore, no such impact
due to influx of people to an area in either
temporarily or permanently is envisaged.
1.29 Introduction of alien species? No Not Applicable
1.30 Loss of native species or genetic No Not Applicable
diversity?
1.31 Any other actions? No No additional actions will be implemented
that would cause physical changes in land
use, topography or water bodies.

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 M/s. Chemcure Lifesciences LLP

2. Use of Natural resources for construction or operation of the Project (such as land,
water, materials or energy, especially any resources which are non-renewable or in
short supply):

Sr. Information/checklist Yes/No Details thereof (with approximate

No. confirmation quantities/rates, wherever possible)
with source of information data
2.1 Land especially undeveloped or No The proposed unit will be set-up 3634.9
agricultural land (ha) m2 in Bamanbore GIDC area.
2.2 Water (expected source & Yes Total consumption of water during the
competing users) unit: KLD plant operation will be 71.97 KL/Day, in
which fresh water will be 16.51 KL/Day
and reuse water will be 55.46 KL/day.
Fresh water will be procured from GIDC
water supply.
Water balance diagram is attached as
Annexure – 6.
2.3 Minerals (MT) No Not Applicable
2.4 Construction material – stone, Yes Locally available construction materials
aggregates, and /soil (expected will be utilized for the construction work.
source – MT)
2.5 Forests and timber (source – MT) Yes A small amount of timber will be utilized
for office building. The same will be
purchased from open market.
2.6 Energy including electricity and Yes Connected load: 95 KVA from (PGVCL).
fuels (source, competing users) Boiler (1 TPH) –Bio Coal – 1 MT/day
Unit: fuel (MT), energy (MW) D.G. set (125 KVA)= Diesel – 9.1 Liter/Hr
2.7 Any other natural resources (use No Not Applicable
appropriate standard units)

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3. Use, storage, transport, handling or production of substances or materials, which
could be harmful to human health or the environment or raise concerns about actual or
perceived risks to human health.

Details thereof (with approximate

Sr. Information/checklist
Yes/No quantities/rates, wherever possible)
No. confirmation
with source of information data
3.1 Use of substances or materials, Yes Adequate measures will be taken as per
which are hazardous (as per the Manufacture, Storage & Import of
MSIHC rules) to human health or Hazardous Chemicals Rules, 1989 and
the environment (flora, fauna, subsequent amendments for handling,
and water supplies) storage and use of the hazardous
materials. However, Risk Assessment
Study will be carried out and based on the
same On-site Emergency Plan will be
prepared. Please refer Annexure – 11 for
details of hazardous raw materials.
3.2 Changes in occurrence of disease No Not Applicable
or affect disease vectors (e.g.
insect or water borne diseases)
3.3 Affect the welfare of people e.g. No Not Applicable
by changing living conditions?
3.4 Vulnerable groups of people who No Not applicable due to the fact that our unit
could be affected by the project is to be set-up on an open land area, this is
e.g. hospital patients, children, away from residential area. Thus, there
the elderly etc. will not be any adverse effect occurred on
vulnerable groups of people.
3.5 Any other causes No Not Applicable

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 M/s. Chemcure Lifesciences LLP
4. Production of solid wastes during construction or operation or decommissioning
(MT/month)

Sr. Information/checklist Yes/ Details thereof (with approximate

No. confirmation No quantities/rates, wherever possible) with
source of information data
4.1 Spoil, Over burden or mine wastes No Not Applicable
4.2 Municipal Waste (domestic and or Yes Details of solid/hazardous waste are
commercial wastes) attached as Annexure – 5.
4.3 Hazardous wastes (as per Yes Details of solid/hazardous waste are
Hazardous Waste Management attached as Annexure – 5.
Rules)
4.4 Other industrial process wastes Yes Details of solid/hazardous waste are
attached as Annexure – 5.
4.5 Surplus product No Not Applicable
4.6 Sewage sludge or other sludge Yes Details of solid/hazardous waste are
from effluent treatment attached as Annexure – 5.
4.7 Construction or demolition waste No Construction wastes will be inert in nature
and will be collected and utilized in filling of
low-lying areas within the unit. Since the
quantity of the construction material is not
available, quantity of construction waste
cannot be estimated. No demolition work
will be carried out for the proposed
manufacturing unit. Therefore, no
demolition waste will be generated.
4.8 Redundant machinery or No Not Applicable
equipment
4.9 Contaminated soils or other No Not Applicable
materials
4.10 Agricultural wastes No Not Applicable
4.11 Other solid wastes No Not Applicable

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 M/s. Chemcure Lifesciences LLP
5. Release of pollutants or any hazardous, toxic or noxious substances to air (Kg/hr)

Sr. Information/checklist Yes/No Details thereof (with approximate

No. confirmation quantities/rates, wherever possible)
with source of information data
5.1 Emissions from combustion of Yes Details of flue gas stack are shown in the
fossil fuels from stationery or Annexure - 8.
mobile sources
5.2 Emissions from production yes Details of Process gas emissions are
processes shown in the Annexure - 8.
5.3 Emissions from materials Yes There will be minor fugitive emissions due
handling including storage or to handling & storage of materials for
transport which proper control measures will be
adopted.
5.4 Emissions from construction Yes Due to construction activities there may
activities including plant and be chances of fugitive emission.
equipment To avoid fugitive emission, proper control
measures will be adopted.
5.5 Dust or odors from handling of Yes Due to handling of construction materials,
materials including construction concentration of particulate matter in
materials, sewage and waste ambient air will slightly increase for that
particular time. Nevertheless, water
sprinkling will be carried out during
construction activity to nullify the effects
of such dusting. During construction and
operation phase adequate sanitary
facilities will be /provided for the
workers.
5.6 Emissions from incineration of No Not Applicable
waste
5.7 Emissions from burning of waste No Not Applicable
in open air (e.g. slash materials,
construction debris)
5.8 Emissions from any other sources No Not Applicable

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6. Generation of Noise and Vibration, and Emissions of Light and Heat:

Sr. Information/checklist Yes/No Details thereof (with approximate

No. confirmation quantities/rates, wherever possible)
with source of information data
6.1 From operation of equipment e.g. Yes Source of noise pollution will be Boiler,
engines, ventilation plant, and D.G. set. As far as noise is concerned
crushers adequate sound enclosures will be
provided to all the equipment’s &
machineries generating high noise.
However, ear protecting devices (like
earmuffs, earplugs) will be provided to all
workers working in such areas where
noise levels will be high. Greenbelt
development will help to abate noise
levels.
6.2 From industrial or similar Yes Sources of noise pollution from the plant
processes are Pumps and motors, machineries. All
the equipment in the unit will be designed
and operated to have the noise level not
exceeding 75-80 dB (A) at a distance of 1.5
m. from the equipment. Also, all the
measures will be taken to limit the noise
level at the plant boundary within the
stipulated limits.
6.3 From construction or demolition Yes Ambient noise level will slightly increase
during construction phase. However,
effect of such noise would be temporary
and negligible.
6.4 From blasting or piling No Not Applicable
6.5 From construction or operational Yes Ambient noise level will slightly increase
traffic due to construction and operational traffic.
However, effect of such noise would be
temporary and negligible.
6.6 From lighting or cooling systems No Not Applicable
6.7 From any other sources No Not Applicable

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7. Risks of contamination of land or water from releases of pollutants into the ground
or into sewers, surface waters, ground water, coastal waters or the sea:

Sr. Information/checklist Yes Details thereof (with approximate

No. confirmation /No quantities/rates, wherever possible) with
source of information data
7.1 From handling, storage, use or No Pucca flooring will be provided and spilled
spillage of hazardous materials materials will be collected and treated in
ETP.
7.2 From discharge of sewage or other No The details of Effluent Treatment Plant are
effluents to water or the land attached as Annexure – 7.
(expected mode and place of
discharge)
7.3 By deposition of pollutants emitted No Minor impact will be anticipated by
to air into the land or into water deposition of pollutants emitted to air into
the land or into water due to Bio Coal will be
used as a fuel and all the necessary Air
Pollution Control measures to be adopted
for controlling the air pollution within the
norms specified by Central/State Pollution
Control Board.
7.4 From any other sources No Not Applicable
7.5 Is there a risk of long term buildup No Not Applicable
of pollutants in the environment
from these sources?

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8. Risk of accidents during construction or operation of the project, which could affect
human health or the environment

Sr. Information/checklist Yes Details thereof (with approximate

No. confirmation /No quantities/rates, wherever possible) with
source of information data
8.1 From explosions, spillages, fires Yes Risk Assessment study will be carried out to
etc. from storage, handling, use or minimize any possible causes that would
production of hazardous substance lead to an accident. Based on the same, the
industry will prepare an onsite emergency
plan highlighting the steps to be taken at the
time of emergency, key personnel to be
contacted; phone numbers of the emergency
help lines etc. Moreover adequate storage
facilities will be provided and special care
will be taken for storage, handling, use and
transport of hazardous materials.
8.2 From any other causes No Not Applicable
8.3 Could the project be affected by No Floods are not likely to occur as water
natural disasters causing bodies away. It may be noted that seismic
environmental damage (e.g. floods, forces will be considered for the
earthquakes, landslides, construction of proposed
cloudburst etc)? structures/buildings as the project site falls
under the Seismic Zone - III.

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 M/s. Chemcure Lifesciences LLP
9. Factors which should be considered (such as consequential development) which
could lead to environmental effects or the potential for cumulative impacts with other
existing or planned activities in the locality

Sr. Information/checklist Yes Details thereof (with approximate

No. confirmation /No quantities/rates, wherever possible) with
source of information data
9.1 Lead to development of
supporting, lities, ancillary
development or development
stimulated by the project which
could have impact on the
environment e.g.
 Supporting infrastructure No Not Applicable
(roads, power supply, waste or
waste water treatment, etc.)
 Housing development
 Extractive industries
 Supply industries
 Other
9.2 Lead to after use of the site, which No Not Applicable
could have an impact on the
environment
9.3 Set a precedent for later No Not Applicable
developments
9.4 Have cumulative effects due to No Not Applicable
proximity to other existing or
planned projects with similar
effects

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 M/s. Chemcure Lifesciences LLP
(III) Environmental Sensitivity
Sr. Information/checklist Yes/ Details thereof (with approximate
No. confirmation No quantities/rates, wherever possible) with
source of information data
1 Areas protected under No Not Applicable
international conventions, national
or local legislation for their
ecological landscape, cultural or
other related value
2 Areas which are important or Yes Hirasar : 1.06 Km in W direction
sensitive for ecological reasons – Macchu river 6.79 km in NW direction
Wetlands, watercourses or other
water bodies, coastal zone,
biospheres, mountains, forests
3 Areas used by protected, No Reserve Forest (Vasundhora) : 6.65 Km in
important or sensitive species of NW
flora or fauna for breeding,
nesting, foraging, resting, over
wintering, migration
4 Inland, coastal, marine or No Not Applicable
underground waters
5 State, National boundaries No Not Applicable
6 Routes or facilities used by the No Not Applicable
public for access to recreation or
other tourist, pilgrim areas
7 Defense installations No Not Applicable
8 Densely populated or built-up area Yes Bamanbore : 3308 (2.9 Km in ENE
direction)
Chotila : 21364 ( 22.3 Km in East Direction)
Rajkot :1,286,678 (27.4 Km in WSW
Direction)
9 Areas occupied by sensitive man- yes Near by hospital: Primary Health Centre
made land uses (hospitals, schools, Bamanbor: 2.5 Km in NE direction.
places of worship, community Near by school: Hirasar primary school: 1.08
facilities) Km in W direction.
10 Areas containing important, high No Not Applicable
quality or scarce resources
(ground water resources, surface
resources, forestry, agricultures,
fisheries, tourism, minerals)
11 Areas already subjected to No Not Applicable
pollution or environmental
damage. (those where existing
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 M/s. Chemcure Lifesciences LLP
legal environmental standards are
exceeded)
12 Areas susceptible to natural No Floods are not likely to occur as water body
hazard which could cause the are away. It may be noted that seismic forces
project to present environmental will be considered for the construction of
problems (earthquakes, proposed structures/buildings as the project
subsidence, landslides, erosion, site falls under the Seismic Zone - III
flooding or extreme or adverse
climatic conditions)

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“I hereby given undertaking that the data and information given in the application and enclosures are
true to the best of my knowledge and belief and I am aware that if any part of the data and information
submitted is found to be false or misleading at any stage, the project will be rejected and clearance
given, if any to the project will be revoked at our risk and cost.

Date: 28-09-2020
Place: Dist. - Rajkot
Signature of the applicant
With Name and Full Address

Mr. Mohitkumar Kishorbhai Dedania

M/s. Chemcure lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -Rajkot,
Gujarat-360023.

Note:
1. The projects involving clearance under coastal regulation zone notification, 1991 shall submit
with the application a C.R.Z map duly demarcated by one of the authorized agencies, showing
the project activities, w.r.t C.R.Z and the recommendations of the state coastal zone
management authority. Simultaneous action shall also be taken to obtain the requisite
clearance under the provisions of the C.R.Z Notification, 1991 for the activities to be located in
the CRZ.
2. The projects to be located within 10 km of the National Parks, Sanctuaries, Biosphere Reserves,
Migratory Corridors of Wild Animals, the project proponent shall submit the map duly
authenticated by Chief Wildlife Warden showing these features vis-à-vis the project location
and the recommendations or comments of the chief wildlife warden thereon”.
3. All correspondence with the Ministry of Environment & Forests including submission of
application for TOR/Environmental Clearance, subsequent clarifications, as may be required
from time to time, participation in the EAC Meeting on behalf of the project proponent shall be
made by the authorized signatory only. The authorized signatory should also submit a
document in support of his claim of being an authorized signatory for the specific project.”

Form-1 for Environment Clearance Page 18

 Annexures

Annexures
Of
Form-1

M/s. Chemcure lifesciences LLP 1

 Annexures

LIST OF ANNEXURES

Contents
ANNEXURE – 1 LOCATION OF THE PROJECT ...................................................................................................3
ANNEXURE – 2 PLANT LAY-OUT .......................................................................................................................7
ANNEXURE – 3 LIST OF PRODUCTS AND RAW MATERIALS ..........................................................................8
ANNEXURE – 4 MANUFACTURING PROCESS ................................................................................................ 29
ANNEXURE- 5 DETAILS OF SOLID/HAZARDOUS WASTE MANAGEMENT ................................................. 30
ANNEXURE – 6: WATER BALANCE DIAGRAM ............................................................................................... 31
ANNEXURE – 7 DETAILS OF EFFLUENT TREATMENT PLANT .................................................................... 32
ANNEXURE – 8 DETAILS OF FLUE & PROCESS GAS STACKS ...................................................................... 35
ANNEXURE – 9 LIST OF MACHINERY/EQUIPMENT/UTILITY ..................................................................... 36
ANNEXURE – 10 SOLVENT RECOVERY SYSTEM ........................................................................................... 37
ANNEXURE – 11 Storage of Raw Material ...................................................................................................... 39
ANNEXURE – 12 LAND DOCUMENTS (Rent Agreement and GIDC letter) .................................................. 50
ANNEXURE – 13 COST OF THE PROJECT ....................................................................................................... 51
ANNEXURE – 14 Risk Assessment Report ..................................................................................................... 52

M/s. Chemcure lifesciences LLP 2

 Annexures

ANNEXURE – 1 LOCATION OF THE PROJECT

India Map Gujarat State Map

Google Image showing Project Site Rajkot District Map

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 Annexures

KEY PLAN
Project Site M/s. Chemcure Lifesciences LLP

M/s. Chemcure lifesciences LLP SOURCE: Google Map

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 Annexures

Google Image of 500 m, 1 km, 5 km, 10 km radius

Red Circle 0.5 km Radius

Green circle 1 km radius
Blue circle 5 km radius
Yellow circle 10 km radius

Sr.
Description Distance
no
1 Nearest Village Hirasar : 1.06 Km in W direction
2 Nearest Town Bamanbor: 2.9 Km in ENE direction.
3 Nearest Railway station Rajkot : 27.9 Km in WSW direction
4 Nearest Airport Rajkot : 29.8 Km in WSW direction
5 Nearest School Hirasar primary school : 1.08 Km in W direction
Primary Health Centre Bamanbor: 2.5 Km in NE
6 Nearest Hospital
direction
7 Nearest Post office Kuchiyadad Post Office 6.9 Km in SW direction.
Hirasar pond 1.33 km in W direction, Macchu
8 Nearest water body
river 6.79 km in NW direction.
Rajkot-Ahmedabad highway (8B) 1.32 km in W
9 Nearest Highway
direction
10 Nearest Reserved forest Reserve Forest (Vasundhora) : 6.65 Km in NW

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 Annexures

SATELLITE IMAGE

M/s. Chemcure lifesciences LLP

SOURCE: Google Earth

Nodes Coordinates
A 22°24'6.86"N 71° 1'27.28"E
B 22°24'7.49"N 71° 1'29.43"E
C 22°24'5.85"N 71° 1'29.94"E
D 22°24'5.26"N 71° 1'29.00"E
E 22°24'5.27"N 71° 1'27.82"E

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 Annexures

ANNEXURE – 2 PLANT LAY-OUT

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 Annexures

ANNEXURE – 3 LIST OF PRODUCTS AND RAW MATERIALS

Type/
Name of API in
Category of
Sr. Production CAS No. Stage of which
Name of the Product CAS No. Said API is used for/End
No Capacity (Product Intermediate Intermediate
Product (API/ (API) Use of said API
. (MT/Month) ) n-1, n-2 etc Used/ End use of
Intermedia
said Intermediate
te)
144689- - - -
1 Olmesartan API Anti-hypertensive
63-4
22457- - - -
2 Benfotiamine API to treat diabetic neuropathy.
89-2
86386- - - -
3 Fluconazole API Anti -Fungal
73-4
117976- - - -
4 Rabeprazole API PPI
89-3
8 102625- - - -
5 Pantoprazole API PPI
70-7
Losartan 124750- - - -
6 API Anti-hypertensive
potassium 99-8
84625-
7 Itraconazole API - - - Anti-Fungal
61-6
148553-
8 Pregabalin API - - - to treat neuropathic pain
50-8
102767-
9 Levetriacetam API - - - Anti-epileptic
28-2

10 Valproic acid 99-66-1 API - - - Anti-epileptic

23593-
11 Clotrimazole 20 API - - - Anti-Fungal
75-1
54965-
12 Albandazole API - - - anthelmintic
21-8

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 Annexures

13 Chlorzoxazone 95-25-0 API - - - muscle relaxant

2277-92-
14 Oxyclozanide API - - - Veterinary
1
15307-
15 Diclofenac sodium API - - - NSAID
86-5

16 Metformin 657-24-9 API - - - Antidiabetic

17 Niclosamide (vet.) 50-65-7 API - - - Veterinary

Chlorpheniramine
18 113-92-8 API - - - antihistamine
maleate
26159-
19 Naproxen sodium API - - - NSAID
34-2

20 Phenyl butazone 50-33-9 API - - - NSAID

4,6-Dichloro-2-
145783- Intermediat 274693-
21 (propylthio)pyrimi N-3 TICAGRELOR platelet aggregation inhibitor
15-9 es 27-5
dine-5- amine
114772- Intermediat 124750-
22 BROMO-OTBN N-1 LOSARTAN Anti-hypertensive
54-2 es 99-8
83857- Intermediat 124750-
23 BCFI N-3 LOSARTAN Anti-hypertensive
96-9 es 99-8
124750- Intermediat 144689-
24 TTBB 40 N-3 OLMESARTAN Anti-hypertensive
51-2 es 63-4
1-H IMIDAZOLE 144689- Intermediat 144689-
25 KSM OLMESARTAN Anti-hypertensive
ESTER 93-0 es 63-4
2-NITRO-4-
54029- Intermediat 54965-21-
26 THOICYNAO- KSM ALBENDAZOLE Anthelmintic
45-7 es 8
ANILINE
2-CHLORO TRITYL 42074- Intermediat 23593-75-
27 KSM CLOTRIMAZOLE Anti-Fungal
CHLORIDE 68-0 es 1

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 Annexures

L-VALINE
6306-52- Intermediat 137862-
28 METHYL ESTER N-2 VALSARTAN Anti-hypertensive
1 es 53-4
.HCL
Bis(2-
Intermediat 129722-
29 chloroethyl)amine 821-48-7 N-3 ARIPIPRAZOLE antidepressant
es 12-9
hydrochloride
2-
(Diethylamino)eth Intermediat
30 869-24-9 KSM AMIODARONE 1951-25-3 antiarrhythmic
yl Chloride es
Hydrochloride
2-
(Dimethylamino)e 4584-46- Intermediat
31 KSM Chlorphenamine 132-22-9 antihistamine
thyl chloride 7 es
hydrochloride
3-
(Dimethylamino)p 5407-04- Intermediat
32 N-3 Amitriptyline 549-18-8 Anti-depressant/Anti -angity
ropyl chloride 5 es
hydrochloride
4-(Aminomethyl) Intermediat
33 56-91-7 N-2 Tranexamic Acid 1197-18-8 hereditary angioedema
Benzoic Acid es
5-
Difluoromethoxy-
2-{[(3,4-
102625- Intermediat 102625-
34 dimethoxy-2- N-1 Pantoprazole Proton Pump Inhibitor(PPI)
64-9 es 70-7
pyridinyl)methyl]t
hio}-
1Hbenzimidazole
2-Chloromethyl
3,4-Dimethoxy 72830- Intermediat 102625-
35 N-2 Pantoprazole PPI
Pyridine HCl 09-2 es 70-7

2-Chloromethoxy-
153259- Intermediat 117976-
36 4-(3-Methoxy N-3 Rabeprazole PPI
31-5 es 89-3
Propoxy)-3-Methyl

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 Annexures

Pyridine

2-[[[4-(3-Methoxy
Propoxy)-3-
117977- Intermediat 117976-
37 Methyl Pyridine-2- N-1 Rabeprazole PPI
21-6 es 89-3
yl] Methyl] Thio]-
1H-Benzimidazole
Chloro acetyl 1131-01- Intermediat
38 N-2 Lidocaine 137-58-6 local anesthetic
Xylidine 7 es
METHYL Intermediat 79794-75-
39 93-60-7 KSM Loratidine antihistamine
NICOTINATE es 5

Total 68 MT/Month

40 R& D Product 0.5

68.5
Total
MT/Month

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 Annexures

LIST OF RAW MATERIALS

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Group-A
Stage-I 2-Cyano-4-methyl biphenyl 114772-53-1 8.54

Stage-I Diisopropyl ether 108-20-3 21.20

Stage-I Dimethyl formamide 68-12-2 24.03

Stage-I Hydrochloric Acid 7647-01-0 12.8

Stage-I Hydrochloric Acid 7647-01-0 3.45

Stage-I Methylenedichloride 75-09-2 46.34

Stage-I Sodium hydroxide 1310-73-2 0.832

Stage-I Sodium azide 26628-22-8 6.408

Stage-I Triethyl amine 121-44-8 5.536

Stage-I Trityl chloride 76-83-5 12.27

Stage-I Zinc chloride 7646-85-7 12.8

Stage-IIA L-Tartaric acid diethyl ester 87-91-2 8

Olmesartan
1
medoxomil Stage-IIA Bromo-Dimethyl hydantoin 77-48-5 23.84

Stage-IIA Butanal 123-72-8 4.19

Stage-IIA Ammonium acetate 631-61-8 23.9

Stage-IIA Acetic acid 64-19-7 64

Stage-IIA Azo bis isobutyronitrile 78-67-1 0.12

Stage-IIA Toluene 108-88-3 80

Stage-IIA 1,2-Dimethoxyethane 110-71-4 40

Stage-IIA Sodium hydroxide 1310-73-2 25.6

Stage-IIA Ammonium carbonate 8000-73-5 24

Stage-IIA Hydrochloric Acid 7647-01-0 48

Stage-IIA Sodium chloride 7440-23-5 24

Stage-IIA Isopropyl alcohol 67-63-0 40

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-IIB Tetrahydrofuran 109-99-9 48

Stage-IIB Methylmagnesium bromide 75-16-1 12.30

Stage-IIB Tetrahydrofuran 109-99-9 22.08

Stage-IIB Hydrochloric Acid 7647-01-0 12.8

Stage-IIB Toluene 108-88-3 24

Stage-IIB Sodium chloride 7440-23-5 8

Stage-III Toluene 108-88-3 103.09

Stage-III Sodium hydroxide 1310-73-2 7.16

Stage-III Hyflo 68855-54-9 0.10

Stage-III Methanol 67-56-1 5.04

Stage-III Methylenedichloride 75-09-2 57.11

Stage-III Sodium bicarbonate 144-55-8 0.13

Stage-III N-Bromo succinamide 128-08-5 6.76

Stage-III Sodium bisulphite 7631-90-5 1.12

Stage-III Tetra butyl Ammonium Bromide 1643-19-2 0.36

Stage-III Azo bis isobutyronitrile 78-67-1 0.32

4-(chloromethyl)-5-methyl-1,3-
Stage-IV 80841-78-7 5.296
dioxol-2-one

Stage-IV Sodium carbonate 497-19-8 0.8

Stage-IV Tetra butyl Ammonium Bromide 1643-19-2 0.8

Stage-IV Ethyl acetate 141-78-6 48

Stage-V Acetone 67-64-1 67.2

Stage-V Hydrochloric Acid 7647-01-0 1.32

Stage-V Activated Carbon 7440-44-0 2.4

Stage-V Ethyl acetate 141-78-6 48

Stage-I Thiamine hydrochloride 67-03-8 6.21

2 Benfotiamine Stage-I Phosphorus Acid 7664-38-2 4.35

Stage-I Tributyl Amine 102-82-9 7.94

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-I Chloroform 67-66-3 13.80

Thiamine monophosphate
Stage-II 273724-21-3 7.59
chloride

Stage-II Benzoyl Chloride 98-88-4 1.24

Stage-II Sodium hydroxide 1310-73-2 2.42

Stage-II Hydrochloric Acid 7647-01-0 0.69

1-[2-(2,4-Difluoro-phenyl) oxiranyl methyl]-

6.2
1H-[1,2,4]triazole 1342260-26-7

1,2,4-Triazole 3.616
288-88-0
Potassium carbonate 10.4
3 Fluconazole 584-08-7
Acetone 50.4
67-64-1
Ethyl acetate 62
141-78-6
Activated carbon 0.8
7440-44-0
2-{[4-(3-Methoxypropoxy)-3-
Stage-I methyl pyridine-2-yl]methylthio}- 117977-21-6 11.76
1H-benzimidazole

Stage-I Acetonitrile 75-05-8 28

Stage-I Sodium hydroxide 1310-73-2 3.536

12.5% Sodium Hypochlorite

Stage-I 7681-52-9 22.4
solution

Stage-I Sodium thiosulfate 7772-98-7 4.72

4 Rabeprazole Sodium
Stage-I Acetic acid use 64-19-7 7.08

Stage-I Ethyl acetate 141-78-6 93.6

Stage-II Sodium hydroxide 1310-73-2 0.93

Stage-II Methanol 67-56-1 12.68

Stage-II n-Buthyl Alcohol 71-36-3 3.24

Stage-II Methyl Tert Butyl Ether (MTBE) 1173021-74-3 71.04

5 Stage-I Maltol 118-71-8 6.8

Pantoprazole Sodium
Stage-I Potassium carbonate 584-08-7 4.4

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-I Acetone 67-64-1 26

Stage-I Dimethyl sulphate 77-78-1 3.6

Stage-II Ammonium Carbonate 8000-73-5 5.2

Stage-II Toluene 108-88-3 41.2

Stage-III Phosphorous oxychloride 10025-87-3 2.8

Stage-III Sodium hydroxide 1310-73-2 0.8

Stage-III Ethylene dichloride 107-06-2 28.8

Stage-IV Hydrogen peroxide (30%) 7722-84-1 3.2

Stage-IV n-Hexane 110-54-3 32

Stage-IV Methylenedichloride 75-09-2 35.2

Stage-IV Acetic acid use 64-19-7 3.2

Stage-IV Sodium hydroxide 1310-73-2 1.76

Stage-V Sodium Methoxide 124-41-4 1.84

Stage-V Methanol 67-56-1 14.4

Stage-VI Acetic Anhydride 108-24-7 3.2

Stage-VII Sodium hydroxide 1310-73-2 1.2

Stage-VII Methylenedichloride 75-09-2 22

Stage-
Thionyl chloride 7719-09-7 3.12
VIII

Stage-
Toluene 108-88-3 28
VIII

Stage-
Acetone 67-64-1 10.4
VIII

5-diFluoromethoxy-2- mercapto-
Stage-IX 97963-62-7 5.6
benzimidazole

Stage-IX Sodium hydroxide 1310-73-2 2

Stage-IX Toluene 108-88-3 19.2

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-X Sodium Hypochloride 7681-52-9 1.6

Stage-X Activated Carbon 7440-44-0 0.8

Stage-I 2-Cyano-4-methyl biphenyl 114772-53-1 8.544

Stage-I Diisopropyl ether 108-20-3 21.208

Stage-I Dimethyl formamide 68-12-2 24.032

Stage-I Hydrochloric Acid 7647-01-0 12.8

Stage-I Hydrochloric Acid 7647-01-0 3.4512

Stage-I Methylenedichloride 75-09-2 46.344

Stage-I Sodium hydroxide 1310-73-2 0.832

Stage-I Sodium azide 26628-22-8 6.408

Stage-I Triethyl amine 121-44-8 5.536

Stage-I Trityl chloride 76-83-5 12.272

Stage-I Zinc chloride 7646-85-7 12.816

6 Losartan potassium Stage-II Valeronitrile 110-59-8 5.104

Stage-II Acetic acid use 64-19-7 4.888

Stage-II Activated carbon 7440-44-0 0.384

Stage-II Sodium hydroxide 1310-73-2 10.88

Stage-II Dimethyl formamide 68-12-2 7.368

Stage-II Disodium EDTA 6381-92-6 0.04

Stage-II Glycine 56-40-6 4.344

Stage-II Hydrochloric Acid 7647-01-0 4.592

Stage-II Hyflo 68855-54-9 0.048

Stage-II Methanol 67-56-1 12.344

Stage-II Sodium hydroxide 1310-73-2 31.352

Stage-II Phosphorous oxychloride 10025-87-3 27.168

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-II Sodium meta bisulphate 7681-57-4 5.04

Stage-II Toluene 108-88-3 33.32

Stage-III Azo bis isobutyronitrile 78-67-1 0.32

Stage-III Sodium hydroxide 1310-73-2 7.16

Stage-III HyFlo 68855-54-9 0.104

Stage-III Methanol 67-56-1 5.048

Stage-III Methylenedichloride 75-09-2 60

Stage-III Sodium borohydride 16940-66-2 2.008

Stage-III Sodium bicarbonate 144-55-8 0.136

Stage-III N-Bromo succinamide 128-08-5 6.76

Stage-III Sodium bisulphite 7631-90-5 1.128

Stage-III Tetra butyl Ammonium Bromide 1643-19-2 0.368

Stage-III Toluene 108-88-3 40.112

Stage-IV Acetonitrile 75-05-8 39.128

Stage-IV Cyclohexane 110-82-7 39.12

Stage-IV Isopropyl alcohol 67-63-0 44.49

Stage-IV Potassium hydroxide 1310-58-3 2.27

Stage-IV Sodium hydroxide 1310-73-2 7.23

Stage-IV Sulfuric acid 7664-93-9 4.25

4-(4-(4-methoxyphenyl)piperazin-
Stage-I 74852-62-3 6.8
1-yl)aniline

Stage-I Phenyl Chloro formate 1885-14-9 3.76

Stage-I Methylenedichloride 75-09-2 43.2

7 ITRACONAZOLE
Stage-I Sodium bicarbonate 144-55-8 2.016

Stage-II Hydrazine Hydrate 7803-57-8 1.08

Stage-II 1,4-Dioxane 123-91-1 42

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-III Formamidine 3473-63-0 0.84

Stage-III Dimethyl formamide 68-12-2 19.2

Stage-III Acetic Acid 64-19-7 2.28

Stage-IV Dimethyl formamide 68-12-2 24

Stage-IV 2-Bromo Butane 78-76-2 2.36

Stage-IV Methanol 67-56-1 16

Stage-IV Potassium Carbonate 584-08-7 1.176

Stage-V Hydrogen Bromide 10035-10-6 2.4

Stage-V Methanol 67-56-1 32

Stage-V Sodium Carbonate 497-19-8 1.56

Stage-VI Cis-Bromo Benzoate 61397-56-6 7.2

Stage-VI Dimethyl formamide 68-12-2 14.4

Stage-VI 1,2,4-Triazole 288-88-0 1.12

Stage-VI Sodium hydroxide 1310-73-2 0.68

Stage-VI Potassium Carbonate 584-08-7 1.12

Stage-VII Methylenedichloride 75-09-2 48

Stage-VII Isopropyl alcohol 67-63-0 48

Stage-VII Methane Sulfonyl Chloride 124-63-0 1.68

Stage-VII Triethyl amine 121-44-8 1.52

Stage-
Dimethyl formamide 68-12-2 80
VIII

Stage-
Methanol 67-56-1 80
VIII

Stage-
Potassium Hydroxide 1310-58-3 0.8
VIII

Stage-
Activated Carbon 7440-44-0 0.64
VIII

3- (Amino methyl)-5-methyl hexanoic acid 8.42

30912-52-6
8 Pregabalin
Mandelic acid 10.97
611-71-2

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Ammonia 1.24
7664-41-7
Citric Acid Monohydrate 6.34
5949-29-1
Methanol 124.44
67-56-1
Activated Carbon 7440-44-0 0.68

SABMA 6.8
7682-20-4
4-Chlorobutyryl chloride 7.36
4635-59-0
Potassium hydroxide 5.6
1310-58-3
9 Levetiracetam
Tetra butyl Ammonium Bromide 0.08
1643-19-2
Methylenedichloride 48
75-09-2
Ethyl acetate 8
141-78-6
Group B
Dipropyl malonic acid 40
10 Valproic Acid 1636-27-7
(chloro(2chlorophenyl) methylene)dibenzene 26.7
42074-68-0
Imidazole 6
288-32-4
Toluene 26.7
108-88-3
11 Clotrimazole
Triethyl amine 9.34
121-44-8
Acetone 30
67-64-1
Activated carbon 0.7
7440-44-0
4-propylthio-o-phenylene diamine 18.70
66608-52-4
Methanol 67-56-1 14.5
12 Albendazole
Ammonium salt of cyano Carbamate 9.80
1111-78-0
Acetic acid use 9.57
64-19-7
Stage-I 4 Chloro 2 Amino Phenol 95-85-2 20

Stage-I Urea 57-13-6 25

13 Chlorzoxazone Stage-I Hydrochloric Acid 7647-01-0 30.8

Stage-I Sodium Hydro Sulphite 7775-14-6 0.2

Stage-II Caustic soda lye 1310-73-2 10.8

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-II Hydrochloric Acid 7647-01-0 16

Stage-II Activated Carbon 7440-44-0 0.8

Stage-II Sodium Hydro Sulphide 16721-80-5 0.4

Stage-III Methanol 67-56-1 28

Stage-III Activated Carbon 7440-44-0 0.6

Stage-III Sodium Hydro Sulphide 16721-80-5 0.2

2,3,5-6-hydroxy benzoic acid 12.28

2215-21-6
Thionyl chloride 7719-09-7 6.06
14 Oxyclozanide
2-amino-4,6-dichloro phenol 9.06
527-62-8
Mono Chloro benzene 82
108-90-7
Stage-I 2,6-dichloro diphenyl amine 15307-93-4 14.95

Stage-I Toluene 108-88-3 12.88

Stage-I Chloro acetyl chloride 79-04-9 10.35

N-Chloro acetyl 2,6-dichloro

Stage-II 15308-01-7 18.4
diphenyl amine

15 Diclofenac Sodium Stage-II Aluminium chloride 7446-70-0 12.88

Stage-III Indolenone 15362-40-0 18.17

Stage-III Sodium hydroxide 1310-73-2 4.715

Stage-IV Activated Carbon 7440-44-0 0.368

Stage-IV Hyflow 68855-54-9 0.23

Dicyano diamide 12.6

461-58-5
Xylene 50.4
1330-20-7
Dimethyl amine HCl 14.74
506-59-2
16 Metformin HCl
Methanol 67-56-1 25.2

Activated Carbon 7440-44-0 0.315

Hyflow 68855-54-9 0.63

17 Niclosamide Stage-I 5-chloro salicylic acid 321-14-2 12.5

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-I Otho Chloro Para Nitro Aniline 121-87-9 13

Stage-I Phosphorous trichloride 7719-12-2 14

Stage-I Toluene 108-88-3 50

Stage-I Methanol 67-56-1 20

Stage-II Methanol 67-56-1 20

Stage-II Activated Carbon 7440-44-0 0.42

Stage-II Hyflow 68855-54-9 0.75

Stage-I 4-Chloro benzyl cyanide 140-53-4 8.55

Stage-I P-chloro pyridine 7379-35-3 3.6

Stage-I Dimethyl amino ethyl chloride 4584-46-7 6.3

18 Chlorpheniramine
Maleate Stage-II Chlorpheniramine base 113-92-8 14.85

Stage-II Maleic acid 110-16-7 7.92

Stage-II Isopropyl alcohol 67-63-0 29.7

1-(6-Methoxynaphthalen-2-yl)
Stage-I 3900-45-6 20.64
ethanone

Stage-I hydroxylamine hydrochloride 5470-11-1 7.74

Stage-I Sodium hydroxide 1310-73-2 8.6

Stage-I Potassium butan-2-olate 41233-93-6 11.18

19 Naproxen sodium (E)-2-(6-methoxy naphtha len-2-

Stage-II 27602-76-2 21.5
yl) propanal oxime

Stage-II Potassium hydroxide 1310-58-3 4.73

Stage-II 2-Butanol 78-92-2 11.61

Stage-II Ammonia 7664-41-7 13.54

Stage-II Hydrochloric Acid 7647-01-0 4.73

Stage-I N-Butyl diethyl malonate 133-08-4 19.58

20 Phenyl Butazone Stage-I Hydrzobenzene 122-66-7 15.62

Stage-I Sodium Methoxide 124-41-4 5.28

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-I Sodium Hydro Sulphide 16721-80-5 0.44

Stage-I Toluene 108-88-3 19.58

Stage-I Acetic acid 64-19-7 15.62

Stage-II Methanol 67-56-1 88

Stage-II Activated Carbon 7440-44-0 0.44

Stage-II Hyflow 68855-54-9 0.33

Group-C
5-amino-2-(propylthio) pyrimidine-4,6-diol 145783-13-7 40
4,6-dichloro-2-
21 (propylthio)pyrimidine-5- Thionyl chloride 7719-09-7 50
amine
Ethyl acetate 120
141-78-6
4'-Methyl-2-cyanobiphenyl 31.96
114772-53-1
22 Bromo OTBN Methylenedichloride 223.60
75-09-2
Bromine 26.44
7726-95-6
Valeronitrile 32.89
110-59-8
Acetic acid use 64-19-7 31.50

Activated Carbon 2.47

7440-44-0
Caustic soda lye 70.10
1310-73-2
Dimethyl formamide 47.47
68-12-2
Disodium EDTA 0.26
6381-92-6
23 BCFI Glycine 27.99
56-40-6
Hydrochloric Acid 29.59
7647-01-0
Hyflo 0.31
68855-54-9
Methanol 46.39
67-56-1
Sodium hydroxide 202.01
1310-73-2
Phosphorous oxychloride 175.05
10025-87-3
Sodium metabisulphite 32.47
7681-57-4

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 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Toluene 266.24
108-88-3
Stage-I OTBN 114772-53-1 20.5

Stage-I Zinc chloride 7646-85-7 41

Stage-I Sodium Azide 26628-22-8 10.25

Stage-I Dimethyl formamide 68-12-2 82

Stage-I Hydrochloric Acid 7647-01-0 20.5

24 TTBB Stage-II Ethylene dichloride 107-06-2 24.6

Stage-II Trityl chloride 76-83-5 246

Stage-II Methanol 67-56-1 29.93

Stage-III Methylenedichloride 75-09-2 215.25

Stage-III Di bromo di methyl hydantoin 77-48-5 15.99

Stage-III Ethyl acetate 141-78-6 71.545

diethyl 2-propyl-1H-imidazole -4,5-

44.5
dicarboxylate 129165-76-0

Methyl magnesium chloride 48.95

Ethyl-4-(1-hydroxy-1- 676-58-4
methylethyl)-2- Tetrahydrofuran 178
25 109-99-9
propylimidazole-5-
carboxylate Ammonium chloride 133.5
12125-02-9
Ethyl acetate 133.5
141-78-6
Diisopropyl ether 89
108-20-3
2-Nitro Aniline 28.8
88-74-4
Ammonium thiocyanate 32.56
2-Nitro-4- 1762-95-4
26
thiocyanoaniline Methanol 60
67-56-1
Chlorine gas 14.8
7782-50-5
Ortho- Chlorobenzotrichloride 40.25
2136-89-2
Benzene 312.225
71-43-2
27 2-Chlorotrityl Chloride
Aluminium Chloride 44.275
7446-70-0
Hydrochloric Acid 80.5
7647-01-0

M/s. Chemcure lifesciences LLP 23

 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Sodium Chloride 24.15
7440-23-5
Toluene 108-88-3 16.1

n-Hexane 158.125
110-54-3
L-Valine 28.8
72-18-4
Methanol 67-56-1 128
L-Valine methyl ester
28 Thionyl chloride 7719-09-7 22.4
hydrochloride
Sodium hydroxide 22.4
1310-73-2
Methylenedichloride 75-09-2 96

Diethanol amine 25
111-42-2
Bis(2-chloroethyl)amine Thionyl chloride 7719-09-7 55
29
Hydrochloride Chloroform 25
67-66-3
IPA HCl 34
‎6638-79-5
Diethyl amino ethanol 100-37-8 41.652
2-(Diethylamino)ethyl
30 Thionyl chloride 7719-09-7 28.836
Chloride Hydrochloride
Ethylene dichloride 89
107-06-2
Dimethyl amino ethanol 37.5
108-01-0
2-(Dimethylamino)ethyl
31 Thionyl chloride 7719-09-7 32.5
chloride hydrochloride
Ethylene dichloride 50
107-06-2
Dimethyl amino propanol 33.5
3-(Dimethyl amino) 108-16-7
32 propyl chloride Thionyl chloride 7719-09-7 42.21
hydrochloride
Ethylene dichloride 80.4
107-06-2
Stage-I Para toluic acid 99-94-5 20.5242

Stage-I N-Bromo succinamide 128-08-5 26.8284

4-(Aminomethyl) Benzoic
33 Stage-I Mono Chloro benzene 108-90-7 71.1
Acid
Stage-II Potassium phthalamide 1074-82-4 27.9186

Stage-II Ethanol 64-17-5 35.55

34 5-Difluoromethoxy-2- Stage-I Maltol 118-71-8 34

M/s. Chemcure lifesciences LLP 24

 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
{[(3,4- dimethoxy-2- Stage-I Potassium carbonate 584-08-7 22
pyridinyl)methyl]thio}-
1Hbenzimidazole Stage-I Acetone 67-64-1 130

Stage-I Dimethyl sulphate 77-78-1 18

Stage-II Ammonium Carbonate 8000-73-5 26

Stage-II Toluene 108-88-3 86

Stage-III Phosphorous oxychloride 10025-87-3 14

Stage-III Sodium hydroxide 1310-73-2 4

Stage-III Ethylene dichloride 107-06-2 144

Stage-IV Hydrogen peroxide (30%) 7722-84-1 16

Stage-IV n-Hexane 110-54-3 160

Stage-IV Methylenedichloride 75-09-2 176

Stage-IV Acetic acid use 64-19-7 16

Stage-IV Sodium hydroxide 1310-73-2 8.8

Stage-V Sodium Methoxide 124-41-4 9.2

Stage-V Methanol 67-56-1 72

Stage-VI Acetic Anhydride use 108-24-7 16

Stage-VII Sodium hydroxide 1310-73-2 6

Stage-VII Methylenedichloride 75-09-2 110

Stage-
Thionyl chloride 7719-09-7 15.6
VIII

Stage-
Toluene 108-88-3 76
VIII

Stage-
Acetone 67-64-1 52
VIII

5-diFluoromethoxy-2- mercapto-
Stage-IX 97963-62-7 28
benzimidazole

Stage-IX Sodium hydroxide 1310-73-2 10

Stage-IX Toluene 108-88-3 74

M/s. Chemcure lifesciences LLP 25

 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Stage-I Maltol 118-71-8 52.36

Stage-I Potassium carbonate 584-08-7 33.88

Stage-I Acetone 67-64-1 187.88

Stage-I Dimethyl sulphate 77-78-1 27.72

Stage-II Ammonium Carbonate 8000-73-5 40.04

Stage-II Toluene 108-88-3 132.44

Stage-III Phosphorous oxychloride 10025-87-3 21.56

Stage-III Sodium hydroxide 1310-73-2 6.16

Stage-III Ethylene dichloride 107-06-2 221.76

Stage-IV Hydrogen peroxide (30%) 7722-84-1 24.64

Stage-IV n-Hexane 110-54-3 246.4

2-Chloromethyl 3,4- Stage-IV Methylenedichloride 75-09-2 135.52

35
Dimethoxy Pyridine HCl
Stage-IV Acetic acid use 64-19-7 24.64

Stage-IV Sodium hydroxide 1310-73-2 13.552

Stage-V Sodium Methoxide 124-41-4 14.168

Stage-V Methanol 67-56-1 110.88

Stage-VI Acetic Anhydride 108-24-7 24.64

Stage-VII Sodium hydroxide 1310-73-2 9.24

Stage-VII Methylenedichloride 75-09-2 107.8

Stage-
Thionyl chloride 7719-09-7 24.024
VIII

Stage-
Toluene 108-88-3 129.36
VIII

Stage-
Acetone 67-64-1 80.08
VIII

2-chloromethyl-4-(3- 4-Chloro-2,3-dimethyl pyridine-N-oxide

36 40.08
hydrochloride 59886-90-7
methoxy propoxy)-3-

M/s. Chemcure lifesciences LLP 26

 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
methylpyridine 3-methoxy propanol 21.71
1589-49-7
hydrochloride
Methylenedichloride 167
75-09-2
Sodium hydroxide 33.4
1310-73-2
Tetra butyl Ammonium Bromide 1.002
1643-19-2
Hydrochloric Acid 16.7
7647-01-0
4-Chloro-2,3-dimethyl pyridine-N-
Stage-I 59886-90-7 34.32
oxide hydrochloride

Stage-I 3-methoxy propanol 1589-49-7 18.59

Stage-I Methylenedichloride 75-09-2 143

Stage-I Sodium hydroxide 1310-73-2 28.6

Stage-I Tetra butyl Ammonium Bromide 1643-19-2 0.858

2-[[(4-(3- Stage-I Hydrochloric Acid 7647-01-0 14.3

methoxypropoxy)-3-
37 methyl- 2-pyridinyl) 2-hydroxymethyl-4-(3-methoxy
methyl] thio]-1H- Stage-II propoxy)-3-methyl pyridine 118175-10-3 34.32
benzimidazole hydrochloride

Stage-II Toluene 108-88-3 97.24

Stage-II Thionyl chloride 7719-09-7 16.445

2-chloromethyl-4-(3-methoxy
Stage-III propoxy)-3-methylpyridine 153259-31-5 35.75
hydrochloride

2-mercapto-1H-benzo [d]
Stage-III 58089-25-1 22.022
imidazol-6-ylium

Chloro acetyl chloride 23.75

79-04-9
2,6- Xylidine 23.75
87-62-7
38 Chloro acetyl Xylidine
Caustic soda lye 0.75
1310-73-2
Toluene 108-88-3 47.5

Nicotinic acid 40
59-67-6
Methanol 100
67-56-1
39 Methyl Nicotinate
Sulfuric acid 0.8
7664-93-9
Chloroform 60
67-66-3

M/s. Chemcure lifesciences LLP 27

 Annexures

Sr. CAS / CI no. of Quantity

Name of Product Name of Raw Material
No. raw materials MT/Month
Sodium bicarbonate 40
144-55-8

M/s. Chemcure lifesciences LLP 28

 Annexures

ANNEXURE – 4 MANUFACTURING PROCESS

Manufacturing process is attached herewith

M/s. Chemcure lifesciences LLP 29

 Annexures

ANNEXURE- 5 DETAILS OF SOLID/HAZARDOUS WASTE

MANAGEMENT
Category
Type/Name of and Quantity
Sr.
Hazardous Schedule as (MT/ Management of HW
No.
waste per HW Annum)
Rules.
Collection, storage, transport and disposal at
1 ETP Sludge 35.3 416.16
approved TSDF site.
Collection, Storage, Transportation (Through
GPS mounted vehicles) and Disposal by
2 Process Residue 28.1 2172.84 sending to registered recycler for
regeneration /for co-processing/ Incinerated
at CHWIF.
Spent Collection, Storage, Transportation and
3 28.3 2357.8
Carbon(process) Incinerated at CHWIF/ for co-processing
Spent Solvent 58485.1 Collection, storage reuse with in process
4 28.6
Collection, Storage, Transportation and
Spent Solvent 142.2
Incinerated at CHWIF/ for co-processing
Collection, Storage, Transportation (Through
GPS mounted vehicles) and Disposal by
Distillation
5 20.3 732.7 sending to registered recycler for
Residue
regeneration /for co-processing/Incinerated
at CHWIF.
Off Specification Collection, Storage, Transportation and
6 28.4 2.3
Drugs Incinerated at CHWIF.
Date Expired Collection, Storage, Transportation and
7 28.5 2.3
Product Incinerated at CHWIF.
Collection, storage and used within premises
8 Used Oil 5.1 0.6
as a lubricant / sold to registered recycler.
Discarded
Collection, storage &sold to registered
9 Plastic Bags / 33.1 267.89
recycler.
Barrels / Liners
Collection and sent to ETP for further
598.17
10 Bleed liquor 35.1 Treatment
583.75 Collection, Storage, reuse in process
Collection, Storage, Partially reused,
Transportation (through GPS mounted
11 Spent HBR 28.1 165.48 vehicle) and Disposed by selling to authorized
end user whom have valid permission from
GPCB as per Haz. Waste Rule-9
Collection, Storage, Transportation and
12 MEE Residue 35.3 642.4
Disposed at TSDF.

M/s. Chemcure lifesciences LLP 30

 Annexures of Form-1

ANNEXURE – 6: WATER BALANCE DIAGRAM

M/s. Chemcure lifesciences LLP 31

 Annexures of Form-1

ANNEXURE – 7 DETAILS OF EFFLUENT TREATMENT PLANT

DOMESTIC EFFLUENT :

 Total 1.31 KL/day sewage will be generated from the domestic activities of the proposed expansion project which will be treated
in ETP along with the dilute stream.
INDUSTRIAL EFFLUENT :

Effluent Treatment Scheme:

 W/W generation from industrial activities will be 68.92 KLD.
 11.2 KLD W/W containing Ammonical Nitrogen will be treated in ammonia stripper and 42.89 KLD high COD, stream containing
washing w/w of 1 KLD, scrubber w/w of 2.5 KLD along with the stream containing Ammonical nitrogen will be treated in VOC
stripper and then the w/w from VOC stripper goes to MEE for further treatment.
 MEE condensate 56.72 KLD with w/w stream coming out from domestic 1.31 KLD, cooling tower blow down 1.14 KLD, RO-reject
i.e. 9.89 KLD, Boiler blow-down i.e. 0.3 KLD will be going to ETP.
 ETP will be consisting of collection cum neutralization tank, primary clariflocculator, aeration tank, secondary clariflocculator, PSF
& ACF and RO-2.
 Sludge generated from ETP and MEE salt will be sent to TSDF site. Hence, the unit will maintain the zero liquid discharge.

M/s. Chemcure lifesciences LLP 32

 Annexures of Form-1

EFFLUENT TREATMENT SCHEME

11.2 KLD Stream Ammonia Stripper

Containing
Ammonical Nitrogen

Collection
tank 1
11 KLD
57.39 KLD (42.89
KLD high COD
effluent, 2.5 KLD
57.39
scrubber water, 11 13.9 KLD RO-2
Condenser 57
KLD ammonical Reject
nitrogen & 1.0
70.9 KLD
washing water W/W from Solvent Stripper
Solvent
Collection cum Stripper Holding Tank MEE &
Neutralization ATFD
Condensate
tank-2
56.72 KLD
69.36 KLD (56.72 KLD
MEE Condensate, 0.3
KLD Boiler Blow down,
1.14 KLD Cooling Tower Primary Secondary
Blow down, 9.89 KLD Clariflocculator Clariflocculator
RO1 Reject & 1.31 KLD
domestic effluent)
Recycle
Aeration Tank RO
Collection cum PSF AC 55.46
Neutralization F 2
tank-3 KLD

Sludge to TSDF Sludge to TSDF

M/s. Chemcure lifesciences LLP 33

 Annexures of Form-1

PRIMARY ETP UNIT DETAILS

Unit No. of units Size/
Capacity
For Ammonical Stream
Collection tank - 1 20 KL 1
Ammonia stripper 0.5 m3/Hr 1
For Concentrated Stream
Collection cum Neutralization Tank - 50 KL 2
2
VOC Stripper 2.5 m3/Hr 1
Holding Tank 50 KL 2
MEE 3 m3/Hr 1
For Dilute Stream
Collection Cum Neutralisation Tank-3 40 KL 3
Primary Clarifloculator 40 KL 3
Aeration tank 40 KL 3
Secondary Clarifloculator 40 KL 3
Pressure sand filter 3 KL/Hr. 1
Activated carbon filter 3 KL/Hr. 1
RO 2 3 KL/Hr. 1

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 Annexures of Form-1

ANNEXURE – 8 DETAILS OF FLUE & PROCESS GAS STACKS

Details of Flue Gas Stacks

Source of Air Pollution

Stack Type of
Sr. emission Type of Quantity of Fuel Control
Height emissions i.e.
No. With Fuel MT/Day Measures
(m) Air Pollutants
Capacity (APCM)
Steam Multi Cyclone
Boiler Separator and SPM  150
1 15 Bio coal 1 MT/day
(1000 adequate stack mg/Nm3
Kg/hr) height SO2  100 ppm
D.G. set Diesel Adequate stack NOx 50 ppm
2 10 9.1 L/Hr.
(125 KVA) height

Details of Process Gas Stacks

Specific Source of emission Stack/Vent Air Pollution Control

Sr. Type of
(Name of the Product & Height Measures
No. emission
Process) (meter) (APCM)
Process Reactor Dual condenser system on
(6 Nos) each reactor (Water + Brine)
1 + 12
HCl,Br2,Cl2,SO2 followed by common dual
Suction hood in Bromine VOC scrubbing system (Water +
Handling Area Alkali) and activated carbon
column
Dual condenser system on
each reactor (Water + Brine)
Reactor Vessel
followed by common dual
2 (5 Nos) 12 NH3, VOC
scrubbing system (Water +
Acidic) and activated carbon
column
Dryer
3 12 VOC Activated carbon column
(2 Nos)

M/s. Chemcure lifesciences LLP 35

 Annexures of Form-1

ANNEXURE – 9 LIST OF MACHINERY/EQUIPMENT/UTILITY

List of machinery
Sr no. Name of equipment Capacity No.
1. Glass Line reactor+ Receiver (250 L) 6.3 KL 1
2. Glass Line reactor+ Receiver (250 L) 5KL 2
3. Glass Line reactor + Receiver (250 L) 3KL 2
4. Glass Line reactor 1KL 1
5. Column+ Condenser glass 16m2 4
6. Colum SS 40feet 1
7. Centrifuge (SS-316) 36" 1
8. Centrifuge (SS-316) 48" 1
9. SS Reactor+ Receiver 250L 5 KL 2
10. SS Reactor 3 KL 2
11. SS Reactor 2 KL 1
12. Column +Condenser 16m2 2
13. Boiler 1TPH 1
14. Chilling Plant 60TR 1
15. Cooling Tower 125TR 1
16. Cooling Tower 250TR 1
17. Glass Assembly 200Ltr 1
18. Tray Dryer 96 plates 1
19. Fluid bed dryer 120 kgs 1
20. Multi mill 12" 1
21. Sifter 24" 1
22. Air Compressor 10 kgs 1

M/s. Chemcure lifesciences LLP 36

 Annexures of Form-1

ANNEXURE – 10 SOLVENT RECOVERY SYSTEM

The unit will provide solvent recovery system/distillation for the recovery of solvent.
The solvents will be recovered and reused back in manufacturing process. The solvent
will be recovered through distillation process. The distillation is a process where
because of difference in boiling point solvent will be recovered. Details of solvent
recovery system/VOCs control system is depicted in Figure. Details of all Solvent
consumption / recovery / loss is as follows:

Consumption Recovered
S.No. Name of Solvent Loss (MT/M) % Recovery
(MT/M) (MT/M)
1 1,2-Dimethoxyethane 40.00 38.40 1.60 96.00
2 1,4-Dioxane 42.00 39.48 2.52 94.00
3 2-butanol 11.61 10.75 0.86 92.59
4 Acetic acid 79.62 77.04 2.58 96.76
5 Acetone 365.16 346.05 19.11 94.77
6 Acetonitrile 40.112 38.912 1.20 97.01
7 Benzene 103.5 89.585 13.92 86.56
Bromo-Dimethyl
8 23.84 12.72 11.12 53.36
hydantoin
9 Chloroform 73.8 70.71 3.09 95.81
10 Cyclohexane 39.128 37.56 1.57 95.99
11 Diisopropyl ether 110.208 100.308 9.90 91.02
12 Dimethyl formamide 219.6 206.98 12.62 94.25
13 Ethanol 35.55 28.44 7.11 80.00
14 Ethyl acetate 229.5 219.5 10.00 95.64
15 Ethylene dichloride 274.8 260.74 14.06 94.88
16 Isopropyl alcohol 77.7 74.14 3.56 95.42
17 Mandelic acid 10.9752 10.88 0.10 99.13
18 Methanol 287.2 271.5 15.70 94.53
19 Methylenedichloride 392.344 372.7 19.64 94.99
20 Mono Chloro benzene 153.1 137.65 15.45 89.91
21 n-Hexane 278.4 263.09 15.31 94.50
22 Tetrahydrofuran 248.08 242.912 5.17 97.92
23 Toluene 496.21 464.054 32.16 93.52
24 Tributyl amine 7.94 7.59 0.35 95.59
25 Xylene 50.4 49.14 1.26 97.50

MT/M 3470.83 219.95

M/s. Chemcure lifesciences LLP 37

 Annexures of Form-1

Figure showing solvent recovery system

Activated
carbon column

 Reactor attached to primary condenser having chilled water circulation of 5°C

followed by secondary condenser having chilled brine circulation of -15°C
followed by activated carbon column.
 This will ensure that they get max. >95% recovery of solvent and if at all any
vapors escapes it will be scrubbed in scrubber.
 The company do not have separate solvent recovery unit within premises, all
solvent distillation is done during processing as a part of process.
 Recovered (distilled) solvents generated from the processing will be reused back
in manufacturing process.

M/s. Chemcure lifesciences LLP 38

 Annexures of Form-1

ANNEXURE – 11 Storage of Raw Material

Sr. No. Name of Raw Material Requirement (MT) Mode of Storage No. of Total
Physical Storage Units Storage Inventory
Per Month Per Day Form Capacity Capacity (MT Day
or KL)

1 (chloro(2chlorophenyl)
26.7 1.068 Liquid HDPE Drum 0.2 38 7.6 7
methylene)dibenzene

2 (E)-2-(6-methoxy naphtha
21.5 0.86 solid bag 0.05 121 6.05 7
len-2-yl) propanal oxime

3 1-(4-Methoxy phenyl )
5.8 0.232 solid bag 0.05 33 1.65 7
Piperazine

4 1,2,4-Triazole 3.616 0.14464 solid bag 0.05 21 1.05 7

5 1-(6-Methoxynaphthalen-2-
20.64 0.8256 solid bag 0.05 116 5.8 7
yl) ethanone

6 1-[2-(2,4-Difluoro-phenyl)
oxiranyl methyl]-1H- 6.2 0.248 solid bag 0.05 35 1.75 7
[1,2,4]triazole

7 12.5% Sodium Hypochlorite

22.4 0.896 Liquid drum 0.2 32 6.4 7
solution

8 2,3,5-6-hydroxy benzoic
12.28 0.4912 solid bag 0.05 30 1.5 3
acid

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 Annexures of Form-1

9 2-{[4-(3-Methoxypropoxy)-
3-methyl pyridine-2-
11.768 0.47072 solid bag 0.05 29 1.45 3
yl]methylthio}-1H-
benzimidazole

10 2,6-dichloro diphenyl amine 14.95 0.598 solid bag 0.05 84 4.2 7

11 2,6- Xylidine* 23.75 0.95 liquid drum 0.2 19 3.8 4

12 2-Bromo Butane 2.36 0.0944 solid bag 0.05 8 0.4 4

13 2-amino-4,6-dichloro
9.064 0.36256 solid bag 0.05 30 1.5 4
phenol

14 2-Cyano-4-methyl biphenyl 8.544 0.34176 solid bag 0.05 48 2.4 7

15 2-chloromethyl-4-(3-
methoxy propoxy)-3-
35.75 1.43 solid bag 0.05 201 10.05 7
methylpyridine
hydrochloride

16 2-hydroxymethyl-4-(3-
methoxy propoxy)-3-methyl 34.32 1.3728 solid bag 0.05 193 9.65 7
pyridine hydrochloride

17 2-mercapto-1H-benzo [d]
22.022 0.88088 solid bag 0.05 124 6.2 7
imidazol-6-ylium

18 2-Nitro Aniline 28.8 1.152 solid bag 0.05 162 8.1 7

19 3- (Amino methyl)-5-methyl 8.4252 0.337008 solid bag 0.05 48 2.4 7

M/s. Chemcure lifesciences LLP 40

 Annexures of Form-1

hexanoic acid

20 4 Chloro 2 Amino Phenol 20 0.8 solid bag 0.05 112 5.6 7

21 3-methoxy propanol 21.71 0.8684 Liquid drum 0.2 31 6.2 7

22 4-(chloromethyl)-5-methyl-
5.296 0.21184 Liquid drum 0.2 8 1.6 7
1,3-dioxol-2-one

23 4-Chlorobutyryl chloride 7.36 0.2944 Liquid drum 0.2 11 2.2 7

24 4-Chloro benzyl cyanide 8.55 0.342 solid bag 0.05 48 2.4 7

25 4'-Methyl-2-cyanobiphenyl 31.9648 1.278592 solid bag 0.05 180 9 7

26 4-Chloro-2,3-dimethyl
pyridine-N-oxide 40.08 1.6032 solid bag 0.05 225 11.25 7
hydrochloride

27 4-propylthio-o-phenylene
18.705 0.7482 solid bag 0.05 105 5.25 7
diamine

28 5-amino-2-(propylthio)
40 1.6 solid bag 0.05 224 11.2 7
pyrimidine-4,6-diol

29 5-diFluoromethoxy-2-
33.6 1.344 solid bag 0.05 189 9.45 7
mercapto- benzimidazole

30 5-chloro salicylic acid 12.5 0.5 solid bag 0.05 70 3.5 7

31 Acetic Anhydride 27.84 1.1136 Liquid drum 0.2 39 7.8 7

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 Annexures of Form-1

32 Activated Carbon 6.27 0.2508 solid bag 0.05 36 1.8 7

33 Aluminium chloride 146.38 5.8552 solid bag 0.05 820 41 7

34 Ammonium acetate 23.92 0.9568 solid bag 0.05 134 6.7 7

35 Ammonium Carbonate 60.04 2.4016 solid bag 0.05 337 16.85 7

36 Ammonium salt of cyano

9.802 0.39208 solid bag 0.05 55 2.75 7
Carbamate

37 Ammonium thiocyanate 32.56 1.3024 Liquid drum 0.2 46 9.2 7

38 Ammonia 14.786 0.59144 Liquid drum 0.2 21 4.2 7

39 Azo bis isobutyronitrile 0.32 0.0128 solid bag 0.05 2 0.1 7

40 Benzoyl Chloride 1.242 0.04968 Liquid drum 0.02 18 0.36 7

41 Bromine 26.44432 1.057773 Liquid bottle 0.003 1411 4.233 4

42 Butanal 4.192 0.16768 Liquid drum 0.2 6 1.2 7

43 Caustic soda lye 80.9 3.236 Liquid drum 0.2 114 22.8 7

44 Chlorine gas 14.8 0.592 gas tonner 0.9 2 1.8 2

45 Chloro acetyl chloride 34.1 1.364 Liquid drum 0.2 48 9.6 7

46 Chlorpheniramine base 14.85 0.594 Liquid drum 0.2 21 4.2 7

47 Cis-Bromo Benzoate 7.2 0.288 solid bag 0.05 41 2.05 7

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 Annexures of Form-1

48 Citric Acid Monohydrate 6.341 0.25364 solid bag 0.05 36 1.8 7

49 Di bromo di methyl
15.99 0.6396 solid bag 0.05 90 4.5 7
hydantoin

50 Dicyano diamide 12.6 0.504 solid bag 0.05 71 3.55 7

51 Diethanol amine 25 1 liquid drum 0.2 35 7 7

52 diethyl 2-propyl-1H-
44.5 1.78 liquid drum 0.2 63 12.6 7
imidazole -4,5-dicarboxylate

53 Diethyl amino ethanol 41.652 1.66608 Liquid drum 0.2 59 11.8 7

54 Dimethyl amine HCl 14.742 0.58968 solid bag 0.05 83 4.15 7

55 Dimethyl amino ethyl

6.3 0.252 solid bag 0.5 4 2 7
chloride

56 Dimethyl amino ethanol 37.5 1.5 Liquid drum 0.2 53 10.6 7

57 Dimethyl amino propanol 33.5 1.34 Liquid drum 0.2 47 9.4 7

58 Dimethyl sulphate 31.32 1.2528 Liquid drum 0.2 44 8.8 7

59 Disodium EDTA 0.3 0.012 solid bag 0.05 2 0.1 7

60 Dipropyl malonic acid 40 1.6 solid bag 0.05 224 11.2 7

61 Formamidine 0.84 0.0336 solid bag 0.05 5 0.25 7

62 Glycine 32.33 1.2932 solid bag 0.05 182 9.1 7

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 Annexures of Form-1

63 Hydrazine Hydrate 1.08 0.0432 Liquid drum 0.2 2 0.4 7

64 Hydrochloric Acid 205.676 8.22704 Liquid drum 0.2 288 57.6 7

65 Hydrogen Bromide 2.4 0.096 Liquid drum 0.2 4 0.8 7

66 Hydrogen peroxide (30%) 27.84 1.1136 Liquid drum 0.2 39 7.8 7

67 hydroxylamine
7.74 0.3096 solid bag 0.05 44 2.2 7
hydrochloride

68 Hydrzobenzene 15.62 0.6248 solid bag 0.05 88 4.4 7

69 Hyflo 1.21 0.0484 solid bag 0.05 7 0.35 7

70 Indolenone 18.17 0.7268 solid bag 0.05 102 5.1 7

71 IPA HCl 34 1.36 Liquid drum 0.2 48 9.6 7

72 L-Tartaric acid diethyl ester 8 0.32 Liquid drum 0.2 12 2.4 7

73 L-Valine 28.8 1.152 solid bag 0.05 162 8.1 7

74 Maleic acid 7.92 0.3168 solid bag 0.05 45 2.25 7

75 Maltol 59.1 2.364 solid bag 0.05 331 16.55 7

76 Methane Sulfonyl Chloride 1.68 0.0672 Liquid drum 0.2 3 0.6 7

77 Methyl magnesium chloride 48.95 1.958 Liquid drum 0.2 69 13.8 7

78 Methyl Tert Butyl Ether

71.04 2.8416 Liquid drum 0.2 100 20 7
(MTBE)

M/s. Chemcure lifesciences LLP 44

 Annexures of Form-1

79 Methylmagnesium bromide 12.304 0.49216 Liquid drum 0.2 18 3.6 7

80 N-Bromo succinamide 33.58 1.3432 solid bag 0.05 189 9.45 7

81 n-Buthyl Alcohol 3.24 0.1296 Liquid drum 0.2 5 1 7

82 N-Butyl diethyl malonate 19.58 0.7832 Liquid drum 0.2 28 5.6 7

83 N-Chloro acetyl 2,6-dichloro

18.4 0.736 solid bag 0.05 104 5.2 7
diphenyl amine

84 Nicotinic acid 40 1.6 solid bag 0.05 224 11.2 7

85 OTBN 20.5 0.82 solid bag 0.05 115 5.75 7

86 Ortho-
40.25 1.61 solid bag 0.05 226 11.3 7
Chlorobenzotrichloride

87 Otho Chloro Para Nitro

13 0.52 solid bag 0.05 73 3.65 7
Aniline

88 Para toluic acid 20.5242 0.820968 solid bag 0.05 115 5.75 7

89 P-chloro pyridine 3.6 0.144 Liquid drum 0.2 6 1.2 7

90 Phenyl Chloro formate 3.76 0.1504 Liquid drum 0.2 6 1.2 7

91 Phosphorous oxychloride 202.22 8.0888 Liquid drum 0.2 284 56.8 7

92 Phosphorus Acid 4.347 0.17388 Liquid drum 0.2 7 1.4 7

93 Phosphorous trichloride 14 0.56 Liquid drum 0.2 20 4 7

M/s. Chemcure lifesciences LLP 45

 Annexures of Form-1

94 Potassium butan-2-olate 11.18 0.4472 solid bag 0.05 63 3.15 7

95 Potassium carbonate 44.28 1.7712 solid bag 0.05 248 12.4 7

96 Potassium hydroxide 10.33 0.4132 solid bag 0.05 58 2.9 7

97 Potassium phthalamide 27.9186 1.116744 solid bag 0.05 157 7.85 7

98 SABMA 6.8 0.272 Liquid drum 0.2 10 2 7

99 Sodium Azide 16.658 0.66632 solid bag 0.05 94 4.7 7

100 Sodium bicarbonate 42.016 1.68064 solid bag 0.05 236 11.8 7

101 Sodium bisulphite 1.128 0.04512 solid bag 0.05 7 0.35 7

102 Sodium borohydride 2.008 0.08032 solid bag 0.05 12 0.6 7

103 Sodium Carbonate 1.56 0.0624 solid bag 0.05 9 0.45 7

104 Sodium Chloride 48.15 1.926 solid bag 0.05 270 13.5 7

105 Sodium Hydro Sulphide 0.44 0.0176 solid bag 0.05 3 0.15 7

106 Sodium Hydro Sulphite 0.2 0.008 solid bag 0.05 2 0.1 7

107 Sodium hydroxide* 268.06 10.7224 solid bag 0.1 429 42.9 4

108 Sodium Hypochloride 1.6 0.064 solid bag 0.05 9 0.45 7

109 Sodium meta bisulphate 5.04 0.2016 solid bag 0.05 29 1.45 7

110 Sodium metabisulphite 32.47461 1.298984 solid bag 0.05 182 9.1 7

M/s. Chemcure lifesciences LLP 46

 Annexures of Form-1

111 Sodium Methoxide 19.45 0.778 solid bag 0.05 109 5.45 7

112 Sodium thiosulfate 4.72 0.1888 solid bag 0.05 27 1.35 7

113 Sulfuric acid 5.056 0.20224 Liquid drum 0.2 8 1.6 7

114 Tetra butyl Ammonium

2.17 0.0868 Liquid drum 0.2 4 0.8 7
Bromide

115 Thiamine hydrochloride 6.21 0.2484 solid bag 0.05 35 1.75 7

116 Thiamine monophosphate

7.59 0.3036 solid bag 0.05 43 2.15 7
chloride

117 Thionyl chloride 64.18 2.5672 Liquid drum 0.2 90 18 7

118 Triethyl amine 14.876 0.59504 Liquid drum 0.2 21 4.2 7

119 Trityl chloride 42.2 1.688 solid bag 0.05 237 11.85 7

120 Urea 25 1 solid bag 0.05 140 7 7

121 Valeronitrile 38 1.52 Liquid drum 0.2 54 10.8 7

122 Zinc chloride 53.81 2.1524 Liquid drum 0.2 76 15.2 7

M/s. Chemcure lifesciences LLP 47

 Annexures of Form-1

Recovere
STATE OF TYPE OF MT/M
d MT/M Additiona NO
SR. MATERIA STORAGE CAP OF TOTAL
MT/ l Solvent OF Inventor
NO RAW MATERIALS L (BAG/DRUM STORAG STORAG
DAY Required UNIT y
. (LIQUID/ / E E
M/Day S
SOLID) TANK)

1 1,2-Dimethoxyethane liquid Drum 40.00 38.40 1.6 0.064 9 0.2 1.8 3

2 1,4-Dioxane liquid Drum 42.00 39.48 1.68 0.1008 10 0.2 2 3
3 2-butanol liquid Drum 11.61 10.75 0.4644 0.0344 3 0.2 0.6 3
4 Acetic acid liquid Drum 79.62 77.04 3.1848 0.1032 17 0.2 3.4 3
5 Acetone liquid Tank 365.16 346.05 14.6064 0.7644 2 10 20 2
6 Acetonitrile liquid Drum 40.112 38.912 1.60448 0.048 9 0.2 1.8 3
7 Benzene liquid Drum 103.5 89.585 4.14 0.5566 27 0.2 5.4 2
Bromo-Dimethyl
8 liquid Drum 23.84 12.72
hydantoin 0.9536 0.4448 10 0.2 2 3
9 Chloroform liquid Drum 73.8 70.71 2.952 0.1236 16 0.2 3.2 3
10 Cyclohexane liquid Drum 39.128 37.56 1.56512 0.06272 9 0.2 1.8 3
110.20
11 Diisopropyl ether liquid Drum 100.308
8 4.40832 0.396 27 0.2 5.4 3
12 Dimethyl formamide liquid Drum 219.6 206.98 8.784 0.5048 49 0.2 9.8 3
13 Ethanol liquid Drum 35.55 28.44 1.422 0.2844 10 0.2 2 3
14 Ethyl acetate liquid Drum 229.5 219.5 9.18 0.4 50 0.2 10 3
15 Ethylene dichloride liquid Drum 274.8 260.74 10.992 0.5624 61 0.2 12.2 1
16 Isopropyl alcohol liquid Drum 77.7 74.14 3.108 0.1424 17 0.2 3.4 3
10.975 0.43900
17 Mandelic acid liquid Drum 10.88
2 8 0.003808 3 0.2 0.6 3
18 Methanol liquid Drum 287.2 271.5 11.488 0.628 64 0.2 12.8 3
392.34 15.6937
19 Methylenedichloride liquid Tank 372.7
4 6 0.78576 2 10 20 2
20 Mono Chloro benzene liquid Drum 153.1 137.65 6.124 0.618 37 0.2 7.4 3

M/s. Chemcure lifesciences LLP 48

 Annexures of Form-1

21 n-Hexane liquid Drum 278.4 263.09 11.136 0.6124 62 0.2 12.4 3

22 Tetrahydrofuran liquid Drum 248.08 242.912 9.9232 0.20672 52 0.2 10.4 3
23 Toluene liquid Tank 496.21 464.054 19.8484 1.28624 3 10 30 2
24 Tributyl amine liquid Drum 7.94 7.59 0.3176 0.014 2 0.2 0.4 3
25 Xylene liquid Drum 50.4 49.14 2.016 0.0504 11 0.2 2.2 3

M/s. Chemcure lifesciences LLP 49

 Annexures of Form-1

ANNEXURE – 12 LAND DOCUMENTS (Rent Agreement and GIDC

letter)

M/s. Chemcure lifesciences LLP 50

 Annexures of Form-1

ANNEXURE – 13 COST OF THE PROJECT

Sr. No. Purpose Cost in Crore
1 Land Rent
2 Building 1.5
3 Plant / Machineries 3.05
4 EMP 1.45
TOTAL 6.0

M/s. Chemcure lifesciences LLP 51

 Annexures of Form-1

ANNEXURE – 14 Risk Assessment Report

M/s. Chemcure lifesciences LLP 52

 Olmesartan medoxomil

A. Brief process of synthesis

Stage 1
2’-cyano-4-methyl biphenyl reacts with Sodium azide to form Tetrazole ring and condense with
Trityl chloride to gives stage 1.
Stage 2
L-tartaric acid diethyl ester was treated with Dibromo dimethyl hydantoin and Butanal to get
Step A product which was reacted with methylmagnesium chloride to get Stage 2 (Step B)
Product.
Stage 3
Step 1 reacted with N-bromosuccinamide and subsequently it was further reacted with Stage 2
(Step B) to get Stage 3 Product.
Stage 4
Stage 3 reacts with 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one in presence of sodium
carbonate, tetrabutylammoniumbromide, Ethyl acetate and water to form Stage 4.

Stage 5

Stage 4 reacts with Hydrochloride in presence of Acetone, water to form Olmesartan medoxomil
tech and purified with Ethyl acetate to form Olmesartan medoximil pharmagrade (Stage 5).

B. Mass Balance
Stage 1

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 2-Cyano-4-methyl DMF loss 0.060 Loss/Emission
1.068
biphenyl
2 Diisopropyl ether Methylene chloride 0.440 Loss/Emission
2.651
loss
3 Dimethyl Diisopropyl ether 0.125 Loss/Emission
3.004
formamide loss
4 Water 8.4 Aqueous effluent 1.113 Recover/Recycle
5 HCl (32%) Aqueous effluent Recover/Recycle
1.6 (Water:2.318, 2.38
HCl:0.062)
6 HCl water (4%) Aqueous effluent To ETP
0.432 (Water:1.281, 1.333
NaCl:0.018)
7 Methylene chloride Aqueous effluent To ETP
Water:11.543,
2.15 HCl:0.062, 7.63
Hydrazoic
acid:0.292)
8 NaOH Solution Solid residue 0.430 To CHWIF
5.793
(48%)
9 Sodium azide 0.104 Zinc chloride 1.602 Recover/Recycle
10 Triethyl amine 0.801 DMF 2.943 Recover/Recycle
11 Trityl chloride 0.692 NaCl 0.689 Recover/Recycle
12 Zinc chloride 1.534 Methylene chloride 9.335 Recover/Recycle
TEA HCl 0.923 Recover/Recycle
Diisopropyl ether 2.526 Recover/Recycle
Stage 1 2.283
Total 29.831 29.831

Stage 2

Step A

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 L-Tartaric acid Toluene loss Loss/Emission
1 0.2
diethyl ester
2 Bromo-Dimethyl Isopropyl alcohol Loss/Emission
2.98 1.59
hydantoin loss
3 Butanal 1,2- Loss/Emission
0.524 Dimethoxyethane 0.4
loss
4 Ammonium acetate 2.99 Acetic acid loss 0.15 Loss/Emission
5 Acetic acid Aqueous effluent Recover/Recycle
8 (Water:4.9, HCl: 7.76
1.10)
6 AIBN Aqueous effluent To ETP
(Water:5.1,
0.015 0.24
NaBr:2.00
(NH4)2CO3:3.00)
7 Toluene Aqueous effluent Recover/Recycle
10 Water: 7.0, 9.6
NaCl:3.00)
8 1,2- Distillation residue To CHWIF
5 4.8
Dimethoxyethane
9 Sodium hydroxide Inorg. Solid Recover/Recycle
3.2 6
(NH4OAc)
10 Ammonium Bromo-Dimethyl Recover/Recycle
3 7.241
carbonate hydantoin
11 Hydrochloric acid Dimethyl hydantoin To CHWIF
6 10
(32%)
12 Sodium chloride 3 Toluene 0.445 Recover/Recycle
13 Process water 7.14 Isopropyl alcohol 3.06 Recover/Recycle
14 Isopropyl alcohol 1,2- Recover/Recycle
5 4.85
Dimethoxyethane
Acetic acid 0.714 Recover/Recycle
Stage 2 (Step A) 0.8
Total 57.849 57.849
AIBN : 2,2'-Azobis[isobutyronitrile]
 Stage 2 (Step B)

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 Step A 0.80 Toluene loss 0.282 Loss/Emission
2 Tetrahydrofuran 6.00 Tetrahydrofuran 0.13 Loss/Emission
loss
3 Methylmagnesium 0.974 Aqueous effluent 4.30 Recover/Recycle
bromide (Water:4, HCl: 0.30)
4 THF 3.326
5 Hydrochloric acid 1.6 Aqueous effluent 4.64 To ETP
(32%) (Water:4.87, Mg
salt:2.00)
6 Toluene 9.00 Distillation residue 0.342 To CHWIF
7 Sodium chloride 1.00 Toluene 2.91 Recover/Recycle
8 Process water 5.57 Tetrahydrofuran 9.004 Recover/Recycle
Stage 2(Step B) 0.662
Total 22.269 22.269

Stage 3

Sr.No Input Qty Output Qty Remarks

(Kg) (Kg)
1 Stage-1 2.283 Methylene chloride 0.356 Loss/Emission
2 2,2’-Azobis (2- 0.04 Toluene 0.371 Loss/Emission
Methyl
propionitrile)
3 Stage 2 (Step B) 0.662 Aqueous effluent 0.835 To ETP
(Water:4.452,
NaHSO4:0.141)
4 Caustic soda lye 0.895 Aqueous effluent 3.158 To ETP
(Water:2.52,
Methanol:0.631, NaBO2:
0.437)
5 Water 9.4 Aqueous effluent 2.894 To ETP
(Water:2.424,
Succinamide:0.470)
6 Hyflo 0.013 Aqueous effluent 1.481 To ETP
(Water:1.424,
NaHCO3:0.017,
AIBN:0.040)
7 Methanol 0.631 Aqueous effluent 3.733 To ETP
(Water:3.032,
NaOH:0.167, TBAB:0.046,
NaBr:0.488)
8 Methylene 7.139 Hy-flo 0.014 To TSDF
chloride
10 Sodium 0.017 Solid Residue 1.531 To TSDF
bicarbonate
11 N-Bromo 0.845 Methylene chloride 6.783 Recover/Recycle
succinimide
12 Sodium 0.141 Toluene 8.929 Recover/Recycle
bisulphite
13 Tetrabutyl 0.046 Stage 3 1.327
ammonium
bromide
14 Toluene 9.3
Total 31.41 31.41

Stage 4

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 Stage 3 1.3 Stage 4 1.44
2 4-(chloromethyl)-5- Ethyl acetate Recover/Rec
methyl-1,3-dioxol- Recovery ycle
2-one 0.662 5.82
3 Sodium carbonate Ethyl acetate Loss Loss/Emissio
0.1 0.18 n
4 Tetra butyl Effluent Water To ETP
Ammonium (Water-3.0,
Bromide 0.1 generated water-
5 Water 0.017, Sodium
chloride-0.11, TBAB-
2.14 0.1) 2.371
6 Ethyl acetate 6.00 Organic Residue To CHWIF
(Organic Impurities-
0.372, EthylAcetate-
0.081) 0.452
Process Emission Scrubber
(Carbon dioxide) 0.042
Total 10.302 10.302

Stage 5

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 Stage 4 1.44 Olmesartan medoxomil 1
2 Acetone 8.4 Acetone Recovery 8.064 Recovery/Recycle
3 Hydrochloric Acetone Loss Loss/Emission
Acid 0.165 0.336
4 Activated Ethyl acetate Recovery Recovery/Recycle
Carbon 0.3 5.82
5 Ethyl acetate 6 Ethyl acetate Loss 0.18 Loss/Emission
6 Water 5.14 Effluent Water To ETP
7 (Water-7.2, Acetone-
0.01, Hydrochloric acid-
0.037) 5.187
8 Spent Carbon 0.3 To CHWIF
9 Organic solid waste To CHWIF
(Organic Impurities-
0.003, Chlorotriphenyl
methane-0.505,
Acetone -0.01, Ethyl
Acetate-0.04) 0.558
Total 21.445 21.445
C. Process Flow Chart
Stage 1

2-Cyano-4-methyl biphenyl DMF loss Loss/Emission

Diisopropyl ether Methylene chloride loss Loss/Emission

Dimethyl formamide Diisopropyl ether loss Loss/Emission

Water Aqueous effluent Recover/Recycle

HCl (32%) Aqueous effluent Recover/Recycle

HCl water (4%) Aqueous effluent To ETP

Methylene chloride Aqueous effluent To ETP

NaOH Solution (48%) Stage 1 Solid residue To CHWIF

Sodiumazide Zinc chloride Recover/Recycle

Triethyl amine DMF Recover/Recycle

Tritylchloride NaCl Recover/Recycle

Zinc chloride Methylene chloride Recover/Recycle

TEA HCl Recover/Recycle

Diisopropyl ether Recover/Recycle

Stage 1

Stage 2 (Step A)

L-Tartaric acid diethyl ester Toluene loss Loss/Emission

Bromo-Dimethyl hydantoin Isopropyl alcohol loss Loss/Emission

Butanal 1,2-Dimethoxyethane loss Loss/Emission

Ammonium acetate Acetic acid loss Loss/Emission

Acetic acid Aqueous effluent Recover/Recycle

AIBN Aqueous effluent To ETP

Toluene Aqueous effluent Recover/Recycle

1,2-Dimethoxyethane Stage 2 Distillation residue To CHWIF

Sodium hydroxide
Step A Inorg. Solid (NH4OAc) Recover/Recycle

Ammonium carbonate Bromo-Dimethyl hydantoin Recover/Recycle

Hydrochloric acid (32%) Dimethyl hydantoin To CHWIF

Sodium chloride Toluene Recover/Recycle

Process water Isopropyl alcohol Recover/Recycle

Isopropyl alcohol 1,2-Dimethoxyethane Recover/Recycle

Acetic acid Recover/Recycle

Stage 2 (Step A)
 Stage 2 (Step B)

Step A Toluene loss Loss/Emission

Tetrahydrofuran Tetrahydrofuran loss Loss/Emission

Methylmagnesium bromide (3M in
Aqueous effluent Recover/Recycle
THF)
Hydrochloric acid (32%) Stage 2 Aqueous effluent To ETP

Toluene
Step B Distillation residue To CHWIF

Sodium chloride Toluene Recover/Recycle

Process water Tetrahydrofuran Recover/Recycle

Stage 2(Step B)

Stage 3

Stage-1 Methylene chloride Loss/Emission

2,2’-Azobis (2-Methyl propio nitrile) Toluene Loss/Emission

Stage 2 (Step B) Aqueous effluent To ETP

Caustic soda lye Aqueous effluent To ETP

Water Aqueous effluent To ETP

HyFlo Aqueous effluent To ETP

Methanol Aqueous effluent To ETP

Stage 3
Methylene chloride Hy-flo To TSDF

Sodium bicarbonate Solid Residue To TSDF

N-Bromo succinamide Methylene chloride Recover/Recycle

Sodium bisulphite Toluene Recover/Recycle

Tetrabutyl ammonium bromide Stage 3

Toluene
 Stage 4

Stage 3
Stage 4

4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
Ethyl acetate Recovery Recover/Recycle

Sodium carbonate Ethyl acetate Loss Loss/Emission

Stage 4
Tetra butyl Ammonium
Effluent Water To ETP
Bromide
Water Organic Residue To CHWIF
Process Emission (Carbon
Loss/Emission
dioxide)

Stage 5

Stage 4
Olmesartan medoxomil
Acetone
Acetone Recovery Recovery/Recycle
Hydrochloric Acid
Acetone Loss Loss/Emission
Activated Carbon
Ethyl acetate Recovery Recovery/Recycle
Ethyl acetate
Stage 5 Ethyl acetate Loss Loss/Emission
Water
Effluent Water To ETP

Spent Carbon To CHWIF

Organic solid waste To CHWIF

D. Route of Synthesis

Stage 1
Stage 2 (Step A)

Stage 2 (Step B)
Stage 3

Stage 4
Stage 5
 Benfotiamine

A. Brief process of synthesis

Stage 1
Thiamine Hydrochloride is reacted with phosphoric acid in presence of water, stir the whole
mass at 40˚C. In other reactor add chloroform, Tributyl Amine and transfer Thiamine
monophosphate Chloride mass from first reactor. Distilled out mix solvent and cool mass
filter and dry to get thiamine monophosphate chloride.

Stage 2

Thiamine monophosphate chloride is reacted with Benzoyl chloride in presence of water and
sodium hydroxide .Adjust ph by hydrochloric acid. Cool the mass filtered and dried to get
Benfotia mine.

B. MASS BALANCE

Step-1
Input Output
S.No Name Qty S.No Name Qty
Kg Kg
01 Thiamine hydrochloride 90.0 01 Thiamine monophosphate 110.0
chloride
02 Phosphorus Acid 63.0 02 Chloroform recover, re-use 190.0
03 Tributyl Amine 115.0 03 Tributyl amine recover, re-use 110.0
04 Chloroform 200.0 04 Ammoniacal Aq. ML with 141.0
organic traces to ETP
05 D. M. water 90.0 05 Drying loss 7.0
Total 558.0 Total 558.0

Step-2
Input Output
S.No Name Qty S.No Name Qty
Kg Kg
01 Thiamine monophosphate 110.0 01 Benfotiamine 117.0
chloride
02 Benzoyl Chloride 18.0 02 Aq. ML with organic traces to 181.0
ETP
03 Sodium hydroxide 35.0 03 Drying Loss 25.0
04 Conc. Hydrochloric acid 10.0 04
05 Water 150.0 05
Total 323.0 Total 323.0
 C. Process Diagram

Step 1 – Thiamine hydrochloride to Thiamine monophosphate chloride

Thiamine Hydrochloride
Poly Phosphoric Acid
Chloroform, Tributyl Amine

HAS/SSR/GLR
1.0 KL

Water SSR Chloroform Recovery

1.0 KL Tributyl amine Recovery

Centrifuge
36” Dia Aqueous ML

RCVD 200 L / FBD 60 Kg

Drying Loss

THIAMINE MONO PHOSPHATE

CHLORIDE
Step 2 – Thiamine monophosphate chloride to Benfotiamine

Thiamine monophosphate chloride Hydrochloric Acid

Benzoyl Chloride
Aq. Sodium Hydroxide

HAS/SSR/GLR
1.0 KL

Water SSR
1.0 KL

Centrifuge
36” Dia Aqueous ML

RCVD 200 L / FBD 60 Kg

Drying Loss

BENFOTIAMINE
 D. CHEMICAL REACTION
Stage 1

Thiamine Hydrochloride Phosphoric Acid

Chemical Formula – C12H18Cl12N4OS Chemical Formula – H3PO4
Molecular weight: 337.27 Molecular Weight: 98.00
337.27+98= 435.27

+ H2O
MW: 18

Thiamine Monophosphate Chloride

Chemical Formula – C12H18Cl2N4O4PS-
Molecular Weight: 416.82

416.82+18=434.82
 Stage 2

Aq. Sodium
+ Hydroxide
Water
Hydrochloric acid
Thiamine Monophosphate Chloride Benzoyl Peroxide
Mol. Wt.: 416.24 Mol. Wt.: 140.57
416.82+140.57= 557.39

+ 2 HCl (73)

+ H2O (18)
Benfotiamine
Mol. Wt.: 466.45
466.45+73+18=557.45
 Fluconazole

A. Brief process of synthesis

Stage 1

1-[2-(2, 4-Difluorophenyl-2, 3-epoxypropyl]-1H-[1, 2, 4] triazole is reacted with 1,2,4-

triazole in the presence of Potassium carbonate, Acetone, Activated carbon and Ethyl
acetate to give Fluconazole as product.

B. Material Balance

Stage 1

Input Output
S.No Name Qty S.No Name Qty
Kg Kg
01 1-[2-(2,4-Difluoro-phenyl) 387.5 01 Fluconazole 500
oxiranyl methyl]-1H-
[1,2,4]triazole
02 1,2,4 Trizol 226 02 Acetone recovery 3100
03 Potassium carbonate 650 03 Ethyl acetate Recovery 3820
04 Acetone 3150 04 Spent carbon 60
05 Ethyl acetate 3875 05 Wet Potassium carbonate 663
recover, sale
06 Activated carbon 50 06 Distilled Residue 120.5
07 Drying loss 75
Total 8338.5 Total 8338.5
C. Process Flow Diagram

1-[2-(2, 4-Difluoro-phenyl) oxiranyl methyl]-1H-[1,2,4]triazole Activated Carbon

1, 2, 4Triazole Ethyl acetate
Potassium carbonate

SSR Carbon Treatment

6.0 KL

Acetone
Pressure Filter Spent carbon
Potassium carbonate

Crystallizer
6.0 KL Acetone recovery
Ethyl Acetate Recovery

Centrifuge
36” Dia / 24” Dia Org ML
Distilled Residue

RCVD
500 L / 750 L

Fluconazole
D. Reaction Chemistry

+ Ethyl Acetate
Acetone

Activated
Carbon
1-[2-(2, 4-Difluorophenyl-2, 3-epoxypropyl] 1,2,4 - Triazole Potassium
-1H-[1, 2, 4] triazole Mol. Wt.:69.07 Carbonate
Mol. Wt.: 237.21

237.21+69.07=306.28

Fluconazole
Mol. Wt.: 306.27
 Rabeprazole Sodium

A. Brief Process of Synthesis

Stage I
2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole is oxidized
with Sodium Hypochlorite solution to give stage I (Rabeprazole base).

Stage II
Stage I is reacted with Sodium hydroxide in methanol to give Rabeprazole Sodium.

B. Mass Balance
Batch time: 4 days
Sr. Quantity Quantity
Input Output Remarks
No. (kg) (kg)
Stage I
2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-
1 yl]methylthio}-1H-benzimidazole 147.1 Stage I 100

Acetonitrile
320
2 recovered
Acetonitrile 350 sale
Vapour loss 30
3 Sodium Hydroxide 44.2
4 12.5% Sodium Hypochlorite solution 280
Aqueous water
5 Sodium thiosulfate 59 1585.8 To ETP
with organic traces
6 Acetic acid 88.5
7 Water 1075
Ethyl acetate
1140
8 Ethyl acetate 1170 recovered Re-use
Vapour loss 30
9 Distillation residue 8 To CHWIF
Total 3213.8 3213.8
Stage II (Rabeprazole Sodium)
1 Stage I 100 Final Product
100
2 Sodium Hydroxide 11.7
3 Methanol 158.5 Methanol+n-
Butanol+ MTBE 1025
4 n-Buthyl Alcohol 40.5 Sale
recoved
5 Methyl Tert Butyl Ether (MTBE) 888 Vapour loss 48.7
6 Distillation residue 25 To CHWIF
Total 1198.7 1198.7
C. Flow Diagram

Stage-I
1. 2-{[4-(3-Methoxypropoxy)-3-methyl
pyridine-2-yl]methylthio}-1H-
benzimidazole
2. Acetonitrile
3. Sodium Hydroxide
4. Sodium Hypochloride
5. Water
3 KL SSR
6. Sodium thiosulf ate
7. Acetic acid

Water
Acetonitrile
Centrif uge
36" Dia
Mother liquor
Aqueous Basic
Ef f luent
RCVD
150 L / 200 L
Ethyl acetate

2 KL SSR
Ethyl acetate Ethyl acetate
Centrif uge
36" Dia
Mother liquor
Distillation
Residue
Stage-1

Stage-II
1. Stage-1
2. Methanol
3. Sodium Hydroxide

2 KL SSR

Sparkler f ilter
1. n-Butyl alcohol
2. Methyl tert-Butyl Ether Methanol

2 KL SSR
Methyl tert-Butyl Ether Methyl tert-Butyl Ether
Centrif uge
36" Dia Distillation
Mother liquor Residue

RCVD
150 L / 200 L

Rabeprazole
D. Route of Synthesis

N
H
N O

S + H 2O 2
N O

hydrogen peroxide
2-{[4-(3-Methoxypropoxy)- Molecular Weight: 34.01
3-methyl pyridine-2-
yl]methylthio}-1H-
benzimidazole
Molecular Weight: 343.44

N
H
N O
+ H2O
S
N O
O Water
Molecular Weight: 18.02
Stage-1
Molecular Weight: 359.44
Manufacturing process of Pentoprazole Sodium :

Sr. Product Name CAS NO. Molecular

No weight
1 Pantoprazole sodium 164579-32-2 432.37
Maltol 118-71-8 126
Dimethyl sulphate 77-78-1 126.13
Potassium carbonate 584-08-7 138
Acetone 67-64-1 58.08
Ammonium Carbonate 506-87-6 96
Toluene 108-88-3 92.14

Water 7732-18-5 18.02

Phosphorous oxy chloride 10025-87-3 153.5

Sodium Hydroxide 1310-73-2 39.99

Methylenedichloride 75-09-2 84.93
Hydrogen peroxide (30%) 7722-84-1 34.01
Acetic acid 64-19-7 60.05
Methanol 67-56-1 32.04
Acetic Anhydride 108-24-7 102
Chloroform 67-66-3 119.38
Thionyl chloride 7719-09-7 118.97
5-diFluoromethoxy-2-
97963-62-7 216
mercapto- benzimidazole

Sodium hypochlorite
(12%) 7681-52-9 74.5

n-Hexane 110-54-3 86.18

Ammonium Chloride 12125-02-9 53.49
Activated Carbon 7440-44-0 12.01
Process :

Stage :1 Maltol is reacted with Diemthyl Sulfate in presence of Potassium Carbonate in

Acetone solvent media to get (Stage-1) Compound.

Stage :2 Stage 1 compound is reacted with Ammonium Carbonate in presence of Toluene to

get Stage-2 Compound.

Stage :3 Stage 2 compound is reacted with Phosphorus Oxychloride in presence of

Methylene Dichloride to get (Stage-3) compound

Stage :4 Stage-3 compound is reacted with Hydrogen Peroxide to get Stage-4 Compound.

Stage :5 Stage-4 compound is reacted with Sodium hydroxide in presence of Methanol to get
Stage-5 Compound.

Stage :6 Stage-5 compound is reacted with Acetic Anhydride to get Stage-6 Compound.

Stage :7 Stage-6 compound is reacted with Sodium Hydroxide in presence of Methylene

Dichloride to get Stage-7 Compound.

Stage :8 Stage-7 compound is reacted with Thionyl Chloride in presence of Chloroform and
Methanol to get Stage-8 Compound.

Stage :9 Stage-8 compound is reacted with (5-Difluoromethoxy)-2-mercapto Benzimidazole

and Sodium Hydroxide in presence of Methylene dichloride to get Stage-9 Compound.

Stage :10 Stage-9 Compound is reacted with Sodium Hypochlorite to get Pantoprazole.

Reaction :
Stage 1: Preparation of 3 methoxy 2- methyl 4- pyrone

Stage 2: Preparation of 3 –Methoxy 2-methyl 4- pyridine

Stage 3: Preparation of 3 –methoxy 2- methyl 4-chloro pyridine

Stage 4: Preparation of 3 methoxy 2-methyl 4- chloro pyridine N oxide

Stage 5: Preparation of 3, 4 dimethoxy 2- methyl pyridine N oxide

Stage 6: Preparation of 2- Acetoxy methyl 3,4 –dimethoxy pyridine

Stage 7: Preparation of 2-hydroxy methyl 3, 4-dimethoxy pyridine

Stage 8: Preparation of 2- chloromethyl dimethoxy pyridine HCL

Stage 9: Preparation of 5 (difluoromethoxy) 2- [[[3 4 dimethoxy 2-
pyridinyl]methyl’thio]-1H-benzimidazole

Stage10: Preparation of pantoprazole

Flow Chart:

Maltol : 85 Kg Acetone recover:310 Kg

Potassium Carbonate : 55 Kg Reaction Acetone loss :25 Kg
Acetone : 325 kg Process emission :10 Kg
Dimethyl Sulfate : 45 Kg

Effluent Water : 6Kg

Centrifuge Organic residue: 19 Kg
Inorganic residue:55 Kg

Ammoniun Carbonate : 65 Kg Toluen Recover : 485 Kg

Toluene : 515 Kg Reaction Tolune loss: 20 Kg
Water: 1004 kg Process emission: 27 Kg

Centrifuge Effluent Water :1314 Kg

Organic Residue: 19 Kg
Posphorus Oxychloride :35 Kg
Ethylene Dichloride: 360 kg
Water : 571 kg Ethylene Dichloride recover: 338 Kg
Reaction Ethylene Dichloride loss:15 Kg
Sodium hydroxide: 10 Kg

Centrifuge Effluent Water : 760 Kg

Organic residue :17 kg

Hydrogen Peroxide : 40 kg
n-Hexane : 400Kg Methylene dichloride recover: 418 Kg
MDC: 440 KG Methylene dichloride loss : 15 Kg
Reaction
n-hexane recover: 378 Kg
Acetic acid: 40 kg
n-Hexane loss :16 kg
Sodium Hydroxide :22 Kg
Water :346.80 Kg
Effluent Water :534 Kg
Centrifuge Organic residue: 21 Kg

Sodium methoxide : 23 Kg Methanol : 169.15 Kg

Methanol : 180 Kg Reaction Methanol Loss: 10 Kg

Organic residue8.85 Kg
Centrifuge Inorganic residue:25 Kg

Acetic acid recover: 21 Kg

Acetic Anhydride: 40 Kg Reaction
Acetic acid loss: 1 Kg
 Distillation residue
Centrifuge
residue:8 Kg

Sodium Hydroxide : 15 kg
Methylene Dichloride : 275 Kg Methylene dichloride recover: 260Kg
Water: 287.6 Kg Reaction Methylene Dichloride loss:11 Kg

Effluent water:395 Kg
Centrifuge:
Organic residue: 9 Kg

Thionyl Chloride: 39 Kg Acetone recover: 164 Kg

Toluene: 350Kg Reaction Acetone loss:8 Kg
Acetone : 175 kg Toluene recover:330 Kg
Toluene loss:15 kg
Process emission :21 Kg

Centrifuge Organic residue: 16 kg

2DFMB : 70 Kg
Sodium Hydroxide: 25 kg Toluene recover: 228 Kg
Toluene: 240 Kg Reaction
Toluene loss: 8 Kg
Water : 1182.2 Kg

Water effluent: 1546 Kg

Centrifuge
Organic residue: 18 Kg
Sodium Hypochloride : 20 kg
Water: 606.8 Kg
Activated carbon : 10Kg

Reaction

Input material Kg/Batch MT/Month Output material Kg/Batch MT/Month

Effluent water: 786 Kg
Maltol 85 0.85 Pantoprazole Sodium
Centrifuge Organic residue: 4 kg
Dimethyl sulphate 45 0.45 Acetone Recovery Spent Carbon: 10 Kg
Potassium carbonate 55 0.55 Toluene Recovery

Acetone Drying MDC Recovery Pantoprazole 100 Kg

Ammonium 65 0.65 Methanol Recovery
Carbonate
Toluene 1105 11.05 Acetic Acid Recovery
Water 5075 50.75 n-Hexane recovery

Phosphorous oxy Ethelene Dichloride

chloride 35 0.35
recovery
Sodium Hydroxide 72 0.72 Distillation Residue
Mass balance :

Kg/ Kg/
Input material Output material
Batch Batch
Stage-1
Maltol 85 Stage-1 85
Potassium carbonate 55 Acetone Recovery 310 Reuse
Acetone 325 Acetone loss 25
Dimethyl sulphate 45 Carbon dioxide gas 10 Scrubber
Waste water 6 ETP
Inorganic Residue 55
Organic Residue 19
Total 510 Total 510

Stage-2
Stage-1 85 Stage-2 75
Ammonium 65 Toluene Recovery 485 Reuse
Carbonate
Toluene 515 Toluene Loss 20
1004.9 Carbon dioxide 27
Water 3 gas
1043.92
Wastewater 6 ETP
Organic Residue 19
Total 1669.92 Total 1669.92

Stage-3
Stage-2 75 Stage-3 75

Phosphorous oxy 35 17
Organic Residue
chloride
Sodium Hydroxide 10 Waste water 606.43
Ethelene Dichloride
Ethylene dichloride 360 338 Reuse
recovery
571.43 Ethelene 15
Water Dichloride Loss
Total 1051.42 Total 1051.42

Stage-4
Stage-3 75 Stage-4 75
Hydrogen peroxide Methylenedichlori
40 de Recovery 418
(30%)
 Methylenedichlori
n-Hexane 400 de Loss 15
Methylenedichlorid
440 n-Hexane recovery 378
e
Acetic acid 40 n-Hexane Loss 16
Sodium Hydroxide 22 Wastewater 440.798
Water 346.80 Organic Residue 21
Total 1363.79 Total 1363.79

Stage-5
Stage-4 75 Stage-5 65
Sodium Methoxide 23 Methanol recover 169.15
Methanol 180 Methanol loss 10
Organic Residue 8.85
Inorganic Residue 25
Total 278 Total 278

Stage-6
Stage-5 65 Stage-6 75
Acetic Acid 21 Reuse
Acetic Anhydride 40 Recovery
Acetic Acid Loss 1
Distilation Residue 8
Total 105 Total 105

Stage-7
Stage-6 75 Stage-7 55
Methylenedichlori 260 Reuse
Sodium Hydroxide 15 de Recover
Methylenedichlorid Methylenedichlori
275 de Loss 11
e
Water 287.68 Waste Water 317.68
Organic Residue 9
Total 652.68 Total 652.68

Stage-8
Stage-7 55 Stage-8 65
Thionyl chloride 39 Acetone Recover 120
Toluene 350 Aceton Loss 7
Acetone 130 Toluene Recover 330
Toluene Loss 15
Sulphur dioxide gas 21
Organic Residue 16
Total 574 Total 574

Stage-9
Stage-8 65 Stage-9 100
5-diFluoromethoxy-
2- mercapto- 70 Toluene Recover 228
benzimidazole
Sodium Hydroxide 25 Toluene Loss 8
Toluene 240 Waste Water 1228.26
Water 1182.27 Organic Residue 18
Total 1582.26 Total 1582.26

Stage-10
Pantoprazole Product
Stage-9 100 Sodium 100
Sodium
20 Organic Residue 4 CHWIF
Hypochloride
Activated Carbon 10 Waste Water 622.89
Water 606.90 Spent carbon 10 CHWIF
Total 736.89 Total 736.89
 Manufacturing of Losartan potassium

A. Brief process of synthesis

Stage 1
2’-cyano-4-methyl biphenyl reacts with Sodium azide to form Tetrazole ring and condense with
Trityl chloride to gives stage 1.

Stage 2

Valeronitrile reacts with Glycine, Phosphorous oxychloride and Dimethyl formamide in

presence of water yields stage 2.

Stage 3

Stage-II and stage-I condense in presence of N-Bromo succinamide to get stage 3.

Stage 4

Stage-III on reaction with potassium hydroxide yields stage 4 (Losartan Potassium API).

B. Mass Balance
Stage 1

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 2-Cyano-4-methyl 1.068 DMF loss 0.060 Loss/Emission
biphenyl
2 Diisopropyl ether 2.651 Methylene chloride loss 0.253 Loss/Emission
3 Dimethyl formamide 3.004 Diisopropyl ether loss 0.125 Loss/Emission
4 Water 12.403 Aqueous effluent 1.113 To ETP
5 HCl (32%) 1.6 Aqueous effluent 3.393 To ETP
(Water:3.315,
HCl:0.062)
6 HCl water (4%) 0.4314 Aqueous effluent 1.336 To ETP
(Water:1.281,
NaCl:0.018)
7 Methylene chloride 5.793 Aqueous effluent 8.485 To ETP
Water:25.543,
HCl:0.062, Hydrazoic
acid:0.292)
8 NaOH Solution (48%) 0.104 Solid residue 0.430 To CHWIF
9 Sodiumazide 0.801 Zinc chloride 1.602 Recover/Recycle
10 Triethyl amine 0.692 DMF 2.943 Recover/Recycle
11 Tritylchloride 1.534 NaCl 0.689 Recover/Recycle
12 Zinc chloride 1.602 Methylene chloride 5.522 Recover/Recycle
TEA HCl 0.923 Recover/Recycle
Diisopropyl ether 2.526 Recover/Recycle
Stage 1 2.283
Total 31.683 31.683
 Stage 2

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 Valeronitrile 0.638 Toluene 0.103 Loss/Emission
2 Acetic acid 0.611 Methanol 0.042 Loss/Emission
3 Activated carbon 0.048 HCl 0.688 Scrubber
4 Caustic soda lye 1.36 DMF 0.019 Loss/Emission
5 Dimethyl formamide Aqueous effluent 2.474 To ETP
(Phosphoric
acid:1.114,
0.921
NaCl:2.092,
Water:9.789,
NaH2PO4:1.291)
6 Disodium EDTA Aqueous effluent 5.142 To ETP
(Water:4.064,
0.005
Methanol:0.057,
NaCl:1.033)
7 Water Aqueous effluent 0.886 To ETP
(Water:0.833,
8.421
Methanol:0.044,
NaCl:0.009)
8 Glycine Aqueous effluent 9.640 To ETP
(Water:7.389,
Methanol:0.383,
NaHPO4:0.689,
NaOH:0.253,
0.543
Disodium
EDTA:0.005,
Sodium
acetate:0.834,
Organic Imp.:0.087)
9 HCl (32%) Spent carbon + 0.485 To TSDF
0.574
Hyflo
10 Hyflo 0.006 Solid residue 0.522 To TSDF
11 Methanol 1.543 Dimethylamine HCl 0.485 Recover/Recycle
12 NaOH solution (48%) 3.919 DMF 0.454 Recover/Recycle
13 Phosphorous Methanol 1.003 Recover/Recycle
3.396
oxychloride
14 Sodium metabisulphite 0.63 Toluene 5.061 Recover/Recycle
15 Toluene 5.165 Stage 2 0.776
Total 27.78 27.78

Stage 3

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 Stage-1 2.283 Methylene chloride 0.33 Loss/Emission
2 2,2’-Azobis (2-Methyl H2 0.044 Loss/Emission
0.04
propio nitrile)
3 Stage 2 0.776 Toluene 0.68 Loss/Emission
4 Caustic soda lye Aqueous effluent To ETP
0.895 (Water:4.708, 2.302
NaHSO4:0.141)
5 Water 13.792 Aqueous effluent 0.709 To ETP
6 HyFlo Aqueous effluent To ETP
(Water:3.527,
0.013 2.595
Methanol:0.631,
NaBO2: 0.437)
7 Methanol 0.631 Aqueous effluent 1.894 To ETP
 (Water:3.424,
Succinamide:0.470)
8 Methylene chloride 7.5 Aqueous effluent To ETP
(Water:3.424,
3.481
NaHCO3:0.017,
AIBN:0.040)
9 Sodium borohydride 0.251 Aqueous effluent 2 To ETP
10 Sodium bicarbonate 0.017 Aqueous effluent To ETP
(Water:9.032,
NaOH:0.167, 1.2
TBAB:0.046,
NaBr:0.488)
11 N-Bromo succinamide 0.845 Aqueous effluent To ETP
(Water:2.362, 2.435
NaOH:0.073)
12 Sodium bisulphite 0.141 Hy-flo 0.013 To TSDF
13 Tetrabutyl ammonium 0.046 Solid Residue 1.531 To CHWIF
bromide
14 Toluene 18.887 Methylene chloride 7.166 Recover/Recycle
Toluene 18.207 Recover/Recycle
Stage 3 1.527
Total 46.117 46.117

Stage 4

Sr.No Input Qty (Kg) Output Qty (Kg) Remarks

1 Acetonitrile 5.014 Acetonitrile 0.150 Loss/Emission
2 Cyclohexane 4.891 Isopropyl alcohol 0.182 Loss/Emission
3 Water 5.533 Cyclohexane 0.196 Loss/Emission
4 Isopropyl alcohol 5.562 Aqueous effluent (Water: 7.945 To ETP
14.516, Na2SO4
:0.770,K2SO4=0.256,
Organic imp:0.018)
5 KOH solution (45%) 0.284 Aqueous effluent 0.185 To ETP
6 Stage 4 seed 0.021 Solid Residue 0.671 To TSDF
7 NaOH Solution (48%) 0.904 Isopropyl alcohol 4.380 Recover/Recycle
8 Stage 3 1.527 Cyclohexane 4.695 Recover/Recycle
9 Sulphuric acid 0.532 Acetonitrile 4.864 Recover/Recycle
10 Stage 4 (Losartan 1.000
Potassium)
Total 24.268 24.268
 C. Process Flow Chart

Stage 1

2-cyano-4-methyl biphenyl DMF loss Emission/Loss

Diisopropyl ether Methylene chloride loss Emission/Loss

Dimethyl formamide Diisopropyl ether loss Emission/Loss

Water Aqueous effluent To ETP

HCl (32%) Aqueous effluent To ETP

HCl water (4%) Aqueous effluent To ETP

Methylene chloride Aqueous effluent To ETP

NaOH solution (48%) Solid residue To CHWIF

Stage 1
Sodium azide Zinc chloride Recover/Recycle

Triethyl amine DMF Recover/Recycle

Tritylchloride NaCl Recover/Recycle

Zinc chloride Methylene chloride Recover/Recycle

TEA HCl Recover/Recycle

Diisopropyl ether Recover/Recycle

Stage 1

Stage 2

Valeronitrile Toluene Emission/Loss

Acetic acid Methanol Emission/Loss

Activated carbon HCl Emission/Loss

Caustic soda lye DMF Emission/Loss

Dimethyl formamide Aqueous effluent To ETP

Disodium EDTA Aqueous effluent To ETP

Water Aqueous effluent To ETP

Glycine Stage 2 Aqueous effluent To ETP

HCl (32%) Spent carbon + Hyflo To TSDF

Hy flo Solid residue To TSDF

Methanol Dimethylamine HCl Recovery/Recycle

NaOH solution (50%) DMF Recovery/Recycle

Sodium metabisulphite Methanol Recovery/Recycle

Toluene Toluene Recovery/Recycle

Phosphorous oxychloride Stage 2

 Stage 3

Stage 1 Methylene dichloride Emission/Loss

2,2'-Azobis(2-methyl H2 Emission/Loss
propionitrile)
Stage 2 Toluene Emission/Loss

Caustic soda lye Aqueous effluent To ETP

Water Aqueous effluent To ETP

Hy flo Aqueous effluent To ETP

Methanol Aqueous effluent To ETP

Methylene chloride Aqueous effluent To ETP

Stage 3
NaBH4 Aqueous effluent To ETP

NaHCO3 Aqueous effluent To ETP

N-Bromo succinamide Aqueous effluent To ETP

Sodium bisulphite Hyflo To TSDF

Tetrabutyl ammonium Solid residue To CHWIF

bromide
Toluene Methylene dichloride Recovery/Recycle

Toluene Recovery/Recycle

Stage 3

Stage 4

Acetonitrile Acetonitrile Emission/Loss

Cyclohexane Isopropyl alcohol Emission/Loss

Water Cyclohexane Emission/Loss

Isopropyl alcohol Aqueous effluent To ETP

KOH solution (45%) Aqueous effluent To ETP

Stage 4
Stage 4 seed Solid residue To TSDF

NaOH solution (48%) Isopropyl alcohol Recovery/Recycle

Sulphuric acid Cyclohexane Recovery/Recycle

Stage 3 Acetonitrile Recovery/Recycle

Stage 4 (Losartan potassium)

D. Route of Synthesis

Stage 1

Stage 2
Stage 3

Stage 4
 Itraconazole
A. Brief process of synthesis

STEP 01

Step 02 Compound is reacted with Phenyl Chloro formate and Sodium Bicarbonate in Methylene
Dichloride to get-3 Compound.

STEP 04

Step 03 Compound is reacted with Hydrazine Hydrate in 1,4-Dioxane to get Step 04 Compound.

STEP 05

Step 04 Compound is reacted with Formamidine and Acetic Acid in Dimethyl Formamide to get Step
05 Compound.

STEP 06

Step 05 Compound is reacted with 2-Bromobutane and Potassium Carbonate in Dimethyl Formamide
and Methanol to get Stage-6 Compound.

STEP 07
Stage-6 Compound is reacted with Hydro bromic Acid and Sodium Carbonate in Methanol to get Step
07 compound.

STEP 08

Cis Bromo benzoate is reacted with 1, 2, 4-Triazole, Potassium Carbonate and Sodium Hydroxide in
Dimethyl formamide to get Stage-8 Compound.

STEP 09

Step 08 Compound is reacted with Methane Sulfonyl Chloride and Triethyl Amine in Methylene
Dichloride and Isoprponal Alcohol to get cis-2-(2,4-Dichlorophenyl)-2-(1H1,2,4-Triazol-1-yl methyl)-
1-3-Dioxolan-4-yl methyl methane sulfonate (Step 09 Compound).

STEP 10

Step 07 compound reacted with Step 09 Compound in presence of Dimethyl Form amide to get
Itraconazole. It is purified in Methanol to get Itraconazole Pharma.
 B. MASS BALANCE
STEP 01

Input Output
Sr.No Name Qty Sr.No Name Qty
Kg Kg
01 4-(4-(4- 0.85 01 Step 01 1.05
methoxyphenyl)piperazin-1-
yl)aniline
02 Phenyl Chloro formate 0.47 02 MDC Recovery 5.10
03 Methylene Dichloride 5.40 03 MDC Loss 0.27
04 Sodium Bicarbonate 0.252 04 Organic Residue 0.42
05 Process Emissions 0.132

Total 6.972 Total 6.972

STEP 02

Input Output
Sr.No Name Qty Sr.No Name Qty
Kg Kg
01 Step 01 1.05 01 Step 02 0.80
02 Hydrazine Hydrate 0.135 02 1,4-Dioxane Recovery 4.935
03 1,4-Dioxane 5.25 03 1,4-Dioxane Loss 0.26
04 Organic Residue 0.44
Total 6.435 Total 6.435

STEP 03

Input Output
Sr.No Name Qty Kg Sr.No Name Qty Kg
01 Step 02 0.80 01 Step 03 0.75
02 Formamidine 0.105 02 DMF Recovery 2.235
03 Dimethyl Formamide 2.40 03 DMF Loss 0.12
04 Acetic Acid 0.285 04 Acetic Acid Recovery 0.28
05 Acetic Acid Loss 0.005
06 Organic Residue 0.2
Total 3.59 Total 3.59

STEP 04
Input Output
Sr.No Name Qty Kg Sr.No Name Qty Kg
01 Step 03 0.75 01 Step 04 0.75
02 Dimethyl Formamide 3.00 02 DMF Recovery 2.8
03 2-Bromo Butane 0.295 03 DMF Loss 0.15
04 Methanol 2 04 Methanol Recovery 1.8
05 Potassium Carbonate 0.147 05 Methanol Loss 0.1
06 Organic Residue 0.545
007 Process Emissions 0.047
Total 6.192 Total 6.192
STEP 05

Input Output
Sr.No Name Qty Sr.No Name Qty
Kg Kg
01 Step 04 0.75 01 Step 05 0.63
02 Hydrogen Bromide 0.3 02 Methanol Recovery 3.78
03 Methanol 4 03 Methanol Loss 0.2
04 Sodium Carbonate 0.195 04 Organic Residue 0.554
05 Process Emissions 0.081
Total 5.245 Total 5.245

STEP 06

Input Output
Sr.No Name Qty Sr.No Name Qty
Kg Kg
01 Cis-Bromo Benzoate 0.9 01 Step 06 0.60
02 Dimethyl Formamide 1.8 02 DMF Recovery 1.67
03 1,2,4-Triazole 0.14 03 DMF Loss 0.09
04 Sodium Hydroxide 0.085 04 Organic Residue 0.66
05 Potassium Carbonate 0.14 05 Process Emissions 0.045
Total 3.065 Total 3.065

STEP 07

Input Output
Sr.No Name Qty Sr.No Name Qty
Kg Kg
01 Step 06 0.60 01 Step 07 0.66
02 Methylene Dichloride 6.00 02 MDC Recovery 5.68
03 Isopropyl Alcohol 6.00 03 MDC Loss 0.30
04 Methane Sulfonyl Chloride 0.21 04 Isopropyl Alcohol Recovery 5.60
05 Triethylamine 0.19 05 Isopropyl Alcohol Loss 0.30
06 Water 2.0 06 Effluent Water 2.35
Organic Residue 0.11
Total 15 Total 15
STEP 08

Input Output
Sr.No Name Qty Sr.No Name Qty
Kg Kg
01 Step 05 0.63 01 Itraconazole 1
02 Step 07 0.66 02 Dimethyl Formamide Recovery 9.43
03 Dimethyl Formamide 10.00 03 Dimethyl Formamide Loss 0.5
04 Methanol 10.00 04 Methanol Recovery 9.5
05 Potassium Hydroxide 0.10 05 Methanol Loss 0.4
06 Activated Carbon 0.08 06 Effluent Water 1.904
07 Water 1.50 07 Organic Residue 0.156
08 Spent Carbon 0.08
Total 22.97 Total 22.97
 C. PROCESS FLOW DIAGRAM

4-(4-(4-methoxyphenyl)piperazin-1-yl)aniline
Phenyl Chloro formate MDC Recover
Step 01 SSR
Methylene Dichloride MDC loss
Sodium Bicarbonate Effluent Residue
Water Organic Residue
Process Emissions

Step 03 1,4-Dioxane Recover

Step 02 SSR
Hydrazine Hydrate
1,4-Dioxane 1,4-Dioxane loss
Water Effluent Water
Organic Residue

Step 04
Formamidine DMF Recover
Step 03 GLR
Dimethyl Formamide DMF loss
Acetic Acid Effluent Water
Water Organic Residue

Step 05
Dimethyl Formamide DMF Recover
2-Bromo Butane DMF Loss
Step 04 SSR
Methanol Methanol Recovery
Potassium Carbonate Methanol Loss
Water Effluent Water
Organic Residue
Process Emissions

Step 06
Hydrogen Bromide Methanol Recover
Step 05 GLR
Methanol Methanol Loss
Sodium Carbonate Effluent Water
Water Organic Residue
Process Emissions

Cis-Bromo Benzoate
Dimethyl Formamide DMF Recover
1,2,4-Triazole Step 06 SSR DMF loss
Sodium Hydroxide Effluent Water
Potassium Carbonate Organic Residue
Water Process Emissions

Step 08 MDC Recover

Methylene Dichloride MDC loss
Isopropyl Alcohol Step 07 SSR IPA Recover
Methane Sulfonyl Chloride IPA loss
Triethylamine Effluent Water
Water Organic Residue

Step 07
Step 09 DMF Recover

Step 8 SSR
Dimethyl Formamide DMF loss
Methanol
Potassium Hydroxide Methanol Recover
Activated Carbon Methanol loss
Water Effluent Water
Organic Residue
Spent Carbon
Itraconazole

D. Reaction Chemistry

Stage-1
 Stage-2

Stage-3
Stage-4

Stage-5
Stage-6

Stage-7
Stage-8
 Pregabalin

A. Brief process of synthesis

 3-(Amino methyl)-5-methyl Hexanoic acid reacts with Mandelic acid with Liq.
Ammonia, citric acid monohydrate, methanol, activated carbon and water to obtain
Pregabalin as product.

B. Mass Balance

Step-1
Input Output
S.No Name Qty S.No Name Qty
Kg Kg
01 3- (Amino methyl)-5-methyl 247.8 01 Pregabalin 237.5
hexanoic acid
02 Mandelic acid 322.8 02 Methanol Recovery, sale 3580
03 Liq. Ammonia 36.5 03 Mandelic acid recovery, re-use 320
04 Citric Acid Monohydrate 186.5 04 Ammoniacal Aq. ML with 3751.1
organic traces to ETP
05 Methanol 3660 05 Spent Carbon 25
06 Activated Carbon 20 06 Drying Loss 80
07 Water 3520
Total 7993.6 Total 7993.6
 C. Process Flow Diagram

3 – (Amino methyl0-5-methyl Hexanoic acid Liquid ammonia

Mandelic acid, Methanol Citric acid monohydrate
Activated Carbon

SSR
6.0 KL

Pressure Filter
Methanol Spent Carbon
Mandelic acid recovery

Crystallizer
Water 6.0 KL
Dist. Methanol

Centrifuge
36” Dia / 24” Dia
Distilled residue

RCVD
500 L / 1.0 KL Drying Loss

Pregabalin
 D. Reaction Chemistry

Step-1

NH2
Mandelic Acid NH2
Liq. Ammonia
COOH Citric Acid Monohydrate
3-Aminomethyl-5-methyl
Methanol COOH
Water
-Hexanoic acid Activated carbon
Pregabalin
C8H17NO2
C8H17NO2
159.23 159.23
 Levetiracetam

A. Brief process of synthesis

React with 2(S) – Aminobutanamide Hydrochloride (SABAM), 4 chlorobutyrylchloride (

4-CBC) and Potassium hydroxide in presence of Dichloro methane (MDC) and tretra -n-
butylamonium bromide (TBAB). Distilled out MDC after completing of reaction and
charge ethyl acetate for product precipitation.

B. Mass balance

Sr Input Quantity Output Quantity Remarks

No (Kg) (Kg)
1 SABMA 85 Potassium 93 Potassium chloride
chloride filtered
2 4-CBC 92 Dichloro 552 Dichloro methane
methane recovery
3 Potassium 70 ethyl 95 ethyl acetate
hydroxide acetate recovery
4 TBAB 1 Recover 15 Recover Loss
Loss
5 Dichloro methane 600 Residue 83 Residue
6 Ethyl acetate 100 Drying Loss 10 Drying Loss
Final 100
Product
Total Input 948 Total 948
Output
 C. PROCESS FLOW DIAGRAM

INPUT KG KG OUT PUT

SABAM 85
4-CBC 92
MDC 600
KOH 70 SSR
TBAB 1 93 KCl Filtered

Ethyl acetate 100 Distillation 552 MDC distillation

CF 193 Mother liquor for

Recovery of Ethyl
acetate

drying 100 Levetiracetam

10 Drying loss

TOTAL INPUT 948 1160 TOTAL OUTPUT

D. Route of Synthesis

CH3 CH3
O
Cl KOH, TBAB
H2N
NH2 HCl
+ Cl N
NH2
O
O O
MDC, Ethyl acetate
2(R)- Aminobutanamide HCl 4- CBC
Levetiracetam
(SABAM)
Mol. Wt. 140.99 Mol. Wt. 170.21
Mol.Wt. 138.59
 Valproic Acid
A. Brief process of synthesis
Dipropyl Malonic acid is heated to boiling to give valproic acid.

B. Mass balance
Input Output
Sr.No Name Qty Kg Sr.No Name Qty Kg
01 Dipropyl malonic acid 2 01 Final Product 1
02 Wash Water 5 02 Wash Water 5
03 Drying Loss 1
Total 7 Total 7

C. Process flow diagram

Dipropyl malonic acid G.L.R Reactor

Wash Water
Wash Water

Drying Drying Loss

Valproic Acid

D. Reaction Chemistry
 Clotrimazole

A. Brief process of synthesis

(chloro(2-chlorophenyl)methylene)dibenzene is condensed with Imidazole in

presence of Triethyl amine, Toluene, Water and Acetone give Clotrimazole.

B. Mass Balance

Sr. Quantity Quantity

Input Output Remarks
No. (kg) (kg)
Clotrimazole
1. (chloro(2chlorophenyl)methylene)dibenzene 1335
Stage I 1000
2. Imidazole 300
Recovered Toluene 1290
3. Toluene 1335 Re-use
Toluene loss 45
4. Triethyl amine 467 Ammoniacal Aq ML
1412 To ETP
5. Water 500 with organic traces
Recovered Acetone 1480
6. Acetone 1500 70 Re-use
Acetone loss
50
7. Activated carbon 35 Spent carbon
125
8. Distilled residue To CHWIF
Total 5472 5472
C. Flow Diagram

1. (chloro(2chlorophenyl)
methylene) dibenzene
2. Imidazole
3. Toluene
4. Triethyamine
5. Water
6 KL SSR Aqueous
Eff luent

Toluene
1. Acetone
2. Activated Carbon
6 KL SSR
Organic layer

Acetone

Sparkler f ilter

6 KL SSR
Acetone
Acetone
Centrif uge
36" Dia Distillation
Mother liquor Residue

RCVD
500 L / 1.0 K L

Clotrimazole
D. Route of Synthesis
 Albendazole

A. Brief process of synthesis

Stage-1:

4-(Propyl Sulfanyl) Benzene-1, 2-Diamine and Ammonium salt of Methyl-N-Cyano

Carbamate is charged in Methanol at ambient temperature. The reaction mass is stirred for
20-30 minutes and Acetic Acid is added. The reaction mass is heated to reflux and
maintained After completion of reflux the reaction mass is cooled to ambient temperature
and centrifuged. The product is washed with Methanol and spin dried. The wet product
unloaded from centrifuge and dried in tray dryer to get dry Albendazole. Mother liquor is
subjected to distillation to recover Methanol. The concentrate reaction mass is cooled and
filtered to get Ammonium Acetate, which is sold to recycler. The solvent residue is dried and
sends to authorized recycler.

B. Mass Balance
Stage-1: Albendazole

Sr. Quantity Quantity

Input Output Remark
No. (KG/Batch) (KG/Batch)
4-propylthio-o- Final
1 645 Albendazole 700
phenylene diamine product
Methanol Reuse in
2 Methanol 500 480
recover process
Ammonium salt of
3 338 Methanol Loss 20
cyano Carbamate
Pass
through
Loss of
4 Acetic acid 330 30 Activated
vapour(drying)
carbon
column
Rule9 or
Ammonium
5 583 send to
acetate (sale)
CHWIF
Total 1813 1813
C. Process flowchart

D. Chemical Reaction
 Chlorzoxazone

A. Brief process of synthesis

STEP 01

4- Chloro -2 – amino phenol is reacted with urea in presence of water, hydrochloric acid and
sodium hydro sulphide. Mass is cool and filter to get Chlorzoxazone crude.

STEP 02

Crude Chlorzoxazone is dissolved in water and sodium hydroxide. Carbon and sodium
hydroxide is added and filter the solution. Collect clear filtrate and add till hydrochloric acid
to precipitate the product. Filter out dried to get Chlorzoxazone 1st Pure.

STEP 03

Chlorzoxazone 1st pure is dissolved in methanol, activated carbon and sodium hydrosulfide
is added and filters the solution. Distilled out methanol completely and add water to
crystallize the product. Filter and dry in vacuum oven to get Chlorzoxazone pure.

B. Mass balance
STEP 01
S.No. Input Kg/Batch Output Kg/Batch Remarks

4 Chloro 2 Chlorzoxazone
01 500 600 Stage 1
Amino Phenol Crude
Ammoniacal Aq.
02 Urea 625 1850 To ETP
ML
Pass through
Hydrochloric
03 770 Drying Loss 150 Activated carbon
Acid
column
Sodium Hydro Ammonia gas to
04 5 300 To Scrubber
Sulphide scrubber
05 DM water 1000
Total 2900 Total 2900
STEP 02

Kg/Ba
Sr.No Input Output Kg/Batch Remark
tch
Chlorzoxazone Chlorzoxazone
01 500 570 Stage 2
Crude Semi Pure
Aq. ML with
02 Caustic Soda Lye 270 540 To ETP
organic traces
Pass through
Activated
03 Hydrochloric Acid 400 Drying Loss 69
carbon
column
04 Activated Carbon 20 Spent carbon 21 To CHWIF
Sodium Hydro
05 10
Sulphide
Total 1200 Total 1200

STEP 03

Sr.No Input Kg/Batch Output Kg/Batch Remark

Chlorzoxazone
01 570 Chlorzoxazone 500 Final Product
Semi Pure
Methanol
02 Methanol 700 680 Recovered, Re-use
recover
Activated
03 15 Spent carbon 16 To CHWIF
Carbon
Sodium Hydro
04 5 Aq. ML 1850 To ETP
sulphide
Pass through
05 Water 1800 Drying Loss 24 Activated carbon
Column
Distillation
20
residue
Total 3090 Total 3090
 C. Process flow diagram
STEP 01

STEP 02
STEP 03

D. Reaction Chemistry

Step 1
Step 2

Step 3
 Oxyclozanide

A. Brief process of synthesis

Charge mono chloro benzene ( MCB), 3,5,6-tri chloro salicylic acid and thionyl chloride
in a reactor. Heat it. Added water and separate the layer and added 2-amino-4,6-
dichloro phenol & mono chloro benzene, after reaction complete, cool the reaction mass
and filter it. Purified in methanol, charcoal.

B. Mass Balance
Stage-1: OXYCLOZANIDE
Sr. Quantity Quantity
Input Output Remark
No. (KG/Batch) (KG/Batch)
2,3,5-6-hydroxy Final
1 153.5 Oxyclozanide 250
benzoic acid Product
Reuse in
2 MCB (mono chloro the
Thionyl chloride 75.8 980
benzene) recover
process
2-amino-4,6-
3 113.3 loss 25.3
dichloro phenol
MCB (mono chloro To
4 1025 SO2 gas 40.8
benzene) Scrubber
To
5 HCl gas 46.5
Scrubber
6 residue 5 To CHWIF
Pass
through
7 Drying loss 20 Activated
carbon
column
Total 1367.6 1367.6

C. Process flowchart
 Flow Diagram of oxyclozanide

3,5,6-tri chloro salicylic acid (153.5 kg) Reactor Monochlorobenzene RECOVER(980 KG)
Monochlorobenzene(1025 KG) LOSS (25.3 KG)
Thionyl chloride(75.8 kg) HCl gas (46.5 kg)
2-amino-4,6-dichloro
phenol(113.3 kg)
SO2 GAS (40.8 KG)
residue (5 kg)

Centrifuge

w/c, Dryer
drying loss (20 kg)

Oxyclozanide : 250 KGS

D. Chemical Reaction
 Diclofenac Sodium

A. Brief process of synthesis

Stage-1

Dichloro diphenyl amine react with chloro acetyl chloride and Toluene as a solvent
forms N-chloro acetyl 2,6-dichloro diphenyl amine. The HCl gas generated to be
scrube in water

Stage-2

N-chloro acetyl 2,6-dichloro diphenyl amine react with Aluminium chloride at reflux
temperature. After completion of reaction reaction mass quench in water then neutch
filter. The product is Indolenone.

Stage-3

Indolenone Hydrolyzed by caustic solution & gives crude Diclofenac sodium, filter it.

Stage-4

Crude Diclofenac sodium is dissolve in D.M. water, carbon, filter, cool & centrifuge it.
Dry it.

B. Mass Balance

Stage-1: N-Chloro acetyl 2,6-dichloro diphenyl amine

Sr.No. Input Kgs. Output Kgs.
1. 2,6-dichloro diphenyl amine 650 N-Chloro acetyl 2,6-dichloro diphenyl amine 800
2. Toluene 560 Toluene recover 535
3. Chloro acetyl chloride 450 loss 25
4. water 600 Effluent acedic 900
2260 2260

Stage-2: Indolenone
Sr.No. Input Kgs. Output Kgs.
1. N-Chloro acetyl 2,6-dichloro diphenyl amine 800 Indolenone 790
2. Aluminium chloride 560 Effluent 1820
3. water 1250
2610 2610
Stage-3: Diclofenac sodium Crude
Sr.No. Input Kgs. Output Kgs.
1. Indolenone 790 Diclofenac sodium crude 1000
2. Sodium hydroxide 205 Effluent 1295
3. water 1300
2295 2295

Stage-4: Diclofenac sodium Pure

Sr.No. Input Kgs. Output Kgs.
1. Diclofenac sodium crude 1000 Diclofenac sodium pure 900
2. Carbon 16 Effluent 1271
3. D.M.Water 1200 Hyflow + carbon (wet cake) 30
4. Hyflow 10 Drying loss 25
2226 2226

C. Process Flow Diagram

Flow Diagram of Diclofenac sodium (stage-1 & 2)

2,6-dichloro diphenyl amine 9650 kgs) Reactor Toluene recover (535 kg)
Toluene (560 kgs) LOSS (25 kg)
Chloro acetyl chloride(450 kgs)
water (600 kgs) effluent (900 kg)

N-Chloro acetyl 2,6-dichloro

diphenyl amine: 800 kgs (stage-1)

stage1 (800 kgs) Reactor

Aluminium chloride (560 kgs)
water (1250 kgs) effluent (1820 kg)

Indolenone : 790 kgs (stage-2)

 Flow Diagram of Diclofenac sodium (stage-3 & 4)

Indolenone (790 kgs) Reactor

sodium hydroxide (205 kgs)
water (1300 kgs)
effluent (1295 kg)

Centrifuge

Diclofenac sodium Crude: 1000

kgs (stage-3)

Reactor
stage3 (1000 kgs) Hyflow & carbon wet cake (30 kgs)
D.M.water (1200 kgs)
CARBON (16 KGS) effluent (1271 kg)
Hyflow (10 kgs)

Centrifuge

drying loss (25 kgs)

w/c, Dryer

Diclofenac sodium : 900 kgs

D. Route of Synthesis
 Metformin HCl

A. Brief process of synthesis

Xylene and dicyandiamide were taken the reaction mixture was heated at 800C.Dimethylamine
hydrochloride was added portion-wise within 2 hours. The reaction mass was stirred for 3 hours. The
reaction mixture was further heated to 100°C to 105°C followed by heating to 140°C. The reaction
mass was stirred for 4 hours and cooled to 95°C. The reaction mass was treated with water and
layers were separated. The organic layer was again extracted with water. The combined aqueous
layer was treated with charcoal and the reaction mass was filtered through a Hyflow bed and washed
with water. The filtrate was taken at 50°C and N2 gas was purged for 30 minutes. The filtrate was
distilled to remove water completely under vacuum at 65°C. The residue thus obtained was treated
with methanol at 40°C to 45°C and cooled to 20°C to 25°C. The product was filtered and washed
with chilled methanol . The wet-cake thus obtained was treated with water at 50°C along with N2 gas
purging for 30 minutes. The solution was distilled to remove water completely under vacuum at
65°C. The residue thus obtained was treated with methanol at 40°C to 45°C to prepare the slurry.
The reaction mass was filtered and dried. The wet-cake was washed with chilled methanol. The
product was dried at 65°C to 70°C FOR 10-12 Hrs. to obtain metformin hydrochloride

B. Mass balance

Sr.No. Input kgs Output kgs

1. Dicyano diamide 200 Metformin HCl 320
2. Xylene 800 Xylene recovered 780
3. Dimethyl amine HCl 234 Methanol recovered 360
4. water 500 Charcoal + Hyflow wet 20
5. Methanol 400 Effluent 641
6. Charcoal 5 Drying loss 28
7. Hyflow 10
Total 2149 2149
 C. Process flow diagram

Flow Diagram of Metformin hydrochloride

Reactor
DICYANODIAMIDE (200 KGS) Xylene recover (780 kgs)
Xylene (800 kgs) Methanol recover (360 kgs)
Water (500 kgs)
methanol (400 kgs) Charcoal with hyflow (20 kgs)
Charcoal (5 kgs)
Hyflow (15 kgs)

Centrifuge
effluent (641 kgs)

w/c, Dryer
drying loss (28 kgs)

Metformin hydrochloride: 320 KGS

D. Reaction Chemistry
 Niclosamide

A. Brief process of synthesis

Stage-1:
5 Chloro salicylic acid and Ortho Chloro Para Nitro Aniline reacts with Phosphorous
trichloride in presence of Toluene to give Stage-1 Product.

Stage-2:
Crude product undergoes Purification in presence of Methanol to give Niclosamide.

B. Mass balance
Stage-1: Niclosamide crude

Sr.No. Input kgs Output kgs

1. 5-chloro salicylic acid 250 Niclosamide Crude 420
2. Otho Chloro Para Nitro Aniline 260 Toluene recovered 975
3. Phosphorous trichloride 280 Methanol recovered 382.5
4. Toluene 1000 water 26.1
5. Methanol 400 Effluent 1968.9
6. Water 1600 Drying loss 17.5
Total 3790 3790

Stage-2: Niclosamide pure

Sr.No. Input kgs Output kgs

1. Niclosamide Crude 420 Niclosamide pure 400
2. Methanol 400 Methanol recovered 380
3. Charcoal 8.4 Charcoal + Hyflow 30.4
wet
4. Hyflow 15 residue 18
5. Drying loss 15
Total 843.4 843.4
 C. Process flow diagram

Flow Diagram of Niclosamide

Reactor
5-Chloro salicylic acid (250 kgs) Toluene recover (975 kgs)
o-chloro p-nitro aniline (250 kgs) Methanol recover (765 kgs)
Water (1600 kgs)
methanol (800 kgs) water (26.1 kgs)
Toluene (1000 kgs)
POCl3 (280 kgs)

Centrifuge
effluent (1968.9 kgs)

w/c, Dryer
drying loss (35 kgs)

Niclosamide Crude: 420 KGS

Reactor
stage-1 (420 kgs)
charcoal (8.4 kgs)
hyflow (15 kgs)
methanol (840 kgs) charcoal + hyfliow wet (30.4 kgs)

Centrifuge REACTOR:
ML Methanol recovered (765 kgs)
Distillation
Residue (18 kgs)

w/c, Dryer
drying loss (15 kgs)

Niclosamide Pure: 400 KGS

D. Reaction Chemistry
 Chlorpheniramine Maleate

A. Brief process of synthesis

Stage-1:
Initially4-Chlorobenzyl cyanide compound is reacted with p-chloro pyridine to give
Chloro phenyl pyridyl acetonitrile. Then react with dimethyl amino ethyl chloride to
give 4-Chloro phenyl dimethyl amino ethyl-pyridyl acetonitrile.

Stage-2:
This intermediate is then react with maleic acid using IPA and getting
Chlorpheniramine maleate, filter and dry at 60-650C for 24 hours.

B. Mass balance

Stage-1: Chlorpheniramine Base

Sr.No. Input kgs Output kgs

1. 4-Chloro benzyl cyanide 950 Chlorpheniramine base 1650
2. P-chloro pyridine 400 Hydrochloric acid 229
3. Dimethyl amino ethyl 700 Cyanic chloride 387
chloride
4. water 1000 Effluent 742
5. Drying loss 42
Total 3050 3050

Stage-2: Chlorpheniramine Maleate

Sr.No. Input kgs Output kgs

1. Chlorpheniramine base 1650 Chlorpheniramine MALEATE 2300
2. Maleic acid 880 WATER 108
3. IPA 3300 IPA recovered 3260
4. Residue 90
5. Drying loss 72
Total 5830 5830
 C. Process flow diagram

Flow Diagram of Chlorpheniramine maleate

Reactor
4-chloro benzyl cyanide (950 kgs) hydrochloric acid (229 kgs)
p-chloro pyridine (400 kgs) cyanic chloride (387 kgs)
Water (1000 kgs)
dimthyl amino ethyl chloride (700 kgs)

Centrifuge
effluent (742 kgs)

w/c, Dryer
drying loss (42 kgs)

Chlorpheniramine base:1650 KGS

Reactor
stage-1 (1650 kgs)
maleic acid (880 kgs)
IPA (3300 KGS) WATER (108 kgs)

Centrifuge REACTOR:
ML IPA recovered (3260 kgs)
Distillation
Residue (90 kgs)

w/c, Dryer
drying loss (72 kgs)

Chlorpheniramine Maleate :2300 KGS

D. Reaction Chemistry
 Naproxen sodium

A. Brief process of synthesis

Stage-1 :
1-(6-Methoxynaphthalen-2-yl)ethanone reacts with Butyl chloroacetate in presence of
Hydroxylamine Hydrochloride, stir at 50-600C for 8-10 Hrs. and filter it to obtain Stage-
1 Compound (wet).

Stage-2 :
Stage-I Compound reacts with Potassium Hydroxide and 2-Butanol in presence of
Toluene, stir at 90-950C for 10-12 Hrs. to obtain Naproxen base (wet).

Stage-3:
Naproxen react with sodium hydroxide using IPA, stir at 30-350C for 2-4 Hrs. and
getting Naproxen sodium and dry at stir at 45-500C for 10-12 Hrs.

B. Mass balance
Stage-1: (E)-2-(6-methoxynaphthalen-2-yl) propanal oxime

Sr.No. Input kgs Output kgs

1. 1-(6-Methoxynaphthalen-2-yl) 480 (E)-2-(6-methoxy naphtha len- 500
ethanone 2-yl) propanal oxime
2. hydroxylamine hydrochloride 180 Sodium chloride 140
3. Sodium hydroxide solution (50%) 200 Effluent 1680
4. Potassium butan-2-olate 260
5. water 1200
Total 2320 2320

Stage-2: 2-(6-methoxynaphthalen-2-yl) propanoic acid

Sr.No. Input kgs Output kgs

1. (E)-2-(6-methoxy naphtha len-2-yl) 500 2-(6-methoxynaphthalen-2-yl) 475
propanal oxime propanoic acid
2. Potassium hydroxide 110 2-butanol recovered 250
3. 2-Butanol 270 effluent 1868
4. Water 1350 HYDROXYL AMINE 62
5. Aq. ammonia 315
6. Conc. HCl 110
Total 2655 2655
 C. Process flow diagram

Flow Diagram of Naproxen sodium (stage-1 & 2)

Reactor
1-(6-Methoxynaphthalen-2-yl) ethanone (480 kgs) sodium chloride (140 kgs)
Hydroxyl amine HCl (180 kgs)
Water (1200 kgs)
sodium hydroxide solution (200 kgs)
potassium butanoate (260 kgs)

Centrifuge
effluent (1680 kgs)

wet cake

(E)-2-(6-methoxy naphtha len-2-yl) propanal oxime:500 KGS

Reactor
stage-1 (500 kgs)
potassium hydroxide (110 kgs) 2-butanol recover (250 kgs)
2-butanol (270 kgs) hydroxyl maine (62 kgs)
water (1350 kgs)
aq. Ammonia (315 kgs)
Conc.HCl (110 kgs)

Centrifuge
effluent (1868 kgs)

wet cake

2-(6-methoxynaphthalen-2-yl) propanoic acid :475 KGS

 Flow Diagram of Naproxen sodium (final)

Reactor
stage-2 (475 kgs)
sodium hydroxide (100 kgs)
IPA (1425 KGS) WATER (37 KGS)

Centrifuge REACTOR:
ML IPA recovered (1390 kgs)
Distillation
Residue (28 kgs)

wet cake/
dryer drying loss (45 kgs)

Naproxen sodium :475 KGS

D. Reaction Chemistry
 Phenyl Butazone

A. Brief process of synthesis

Stage 1: Phenyl butazone crude :

N-Butyl diethyl malonate, Hydroazobenzene and sodium methoxide powder is refluxed at
80- 850C for 12 hour. Water is added into the reaction mass and pH adjusted with sodium
hydrosulphide powder. Toluene is added and separated from reaction mass. Acetic acid is
added and pH adjusted to 4-4.5 . Reaction mass is filtered and wash with water. Wet cake is
dried at 50-600C for 8-10 Hrs. to obtain Phenyl butazone crude.

Stage 2: Phenyl butazone pure:

Crude Phenyl butazone dissolve in methanol at 60 to 650C temperature. Reaction mass is
treated with activated carbon and solution is filtered. Filtered reaction mass is chilled to 0-
50C and filtered. Wet cake is dried at 50-600C for 12 hrs. and packed.

B. Mass balance

Stage-1: Phenyl Butazone Crude

Sr.No. Input kgs Output kgs

1. N-Butyl diethyl malonate 890 Phenyl butazone Crude 1000
2. Hydrzobenzene 710 Toluene recovered 850
3. Sodium methoxide powder 240 Acetic acid recovered 680
4. Sodium hydrosulfide 20 ethanol 379
5. Toluene 890 Effluent 3163
6. Acetic acid 710 Drying loss 58
7. water 2670
Total 6130 6130

Stage-2: Phenyl Butazone pure

Sr.No. Input kgs Output kgs

1. Phenyl butazone Crude 1000 Phenyl butazone pure 950
2. Methanol 2000 Methanol recovered 1970
3. Charcoal 20 Charcoal + Hyflow wet 40
4. Hyflow 15 Drying loss 30
5. residue 45
Total 3035 3035
 C. Process flow diagram

Flow Diagram of Phenyl Butazone (stage-1 & 2)

Reactor
N-butyl diethyl mlonate (890 kgs) Toluene recovered (850 kgs)
hydrozobenzene (710 kgs) Acetic acid recovered (680 kgs)
Water (2670 kgs) ethanol (379 kgs)
sodium hydrosulfide (20 kgs)
sodium methoxide (240 kgs)
Toluene (890 kgs)
Acetic acid (710 kgs)

Centrifuge
effluent (3161 kgs)

wet cake
drying loss (58 kgs)

Phenyl butazone Crude:1000 KGS

Reactor
stage-1 (1000 kgs)
Methanol (4000 kgs)
Charcoal (20 kgs) charcoal + hyflow wet (40 kgs)
Hyflow (15 kgs)

Centrifuge REACTOR:
ML Methanol recovered (3940 kgs)
Distillation
Residue (45 kgs)

wet cake/ drying loss (65 kgs)

dryer

Phenyl butazone pure : 950 KGS

D. Reaction Chemistry
 4,6-dichloro-2-(propylthio)pyrimidine-5-amine

A. Brief process of synthesis

5-amino-2-(propylthio)pyrimidine-4,6-diol and Thionyl chloride were mixed and the

mixture was heated at reflux temperature for 20 hrs. Excess of Thionyl chloride was
evaporated at reduced pressure. Water and EtOAc were added, and the layers were
separated. The aqueous layer was extracted with EtOAc ,and the combined organic
layers were evaporated providing 4,6-dichloro-2-(propylthio)pyrimidine-5-amine as a
brown oil.

B. Mass balance

Sr.No. Input kgs Output kgs

1. 5-amino-2-(propylthio) 200 4,6-dichloro-2- 200
pyrimidine-4,6-diol (propylthio)
pyrimidine-5-amine
2. Thionyl chloride 250 Sulfur dioxide 63.6
3. water 1000 Water 17.9
4. Ethyl acetate 600 Ethyl acetate 565
recovered
5. effluent 1203.5
Total 2050 2050

C. Process flow diagram

Flow Diagram of 4,6-dichloro-2-(propylthio)pyrimidine-5-amine

Reactor
5-amino-2-(propylthio) pyrimidine-4,6-diol
(200 KGS) ethyl acetate recover (565 kgs)
Thinyl chloride (250 kgs) sulfur dioxide (63.6 kgs)
Water (1000 kgs) water (17.9 kgs)
ethyl acetate (600 kgs) effluent (1203.5 kgs)

4,6-dichloro-2-(propylthio) pyrimidine-5-amine : 200 KGS ( oil)

D. Reaction Chemistry
 4-Bromomethyl-2-cyanobiphenyl (Bromo OTBN)

A. Brief process of synthesis

 Charge Methylene Dichloride to reactor.

 Charge 4-Methyl-2-Cyanobiphenyl to reaction mass.
 Heat the reaction mass to 40⁰C temperature.
 Charge Bromine to reaction mass within 2 hrs.
 Maintain the reaction mass for 1 hr.
 Wash the reaction mass with water.
 Aqueous layer separation and collect the organic layer.
 Charge Methylene Dichloride.
 Chilled the reaction mass
 The Reaction mass is centrifuged and dried the product.

B. Mass Balance

INPUT Kg/Batch OUT PUT Kg/Batch

4'-Methyl-2- 285.4 4-Bromomethyl-2- 360
cyanobiphenyl cyanobiphenyl
Methylene 1996.44 Methylene Dichloride 1956.37
Dichloride Recovery
236.11 1422.2
Bromine Waste Water
1426.05 123.2
Water Spent HBr (By-Product)

Distillation Residue 25.1

Evaporation Loss 17.2

Methylene Dichloride Loss 39.93

TOTAL 3944 TOTAL 3944

 C. Process Flow Diagram

D. Chemical Reaction

CN CN

+ Br2 + HBr
Methylene Dichloride
Bromine Hydrogen
M.W: 160.0 Br Bromide
M.W: 81.0
CH3

2-Cyano-4'-methylbiphenyl 4-Bromomethyl-2-cyanobiphenyl
M.W: 193.0 M.W: 272.0

193.0+160.0= 353.0 272.0+81.0.0= 353.0

 2-Butyl-4-chloro-5-formylimidazole (BCFI)

A. Brief process of synthesis

Valeronitrile reacts with Glycine, Phosphorous oxychloride and Dimethyl formamide in
presence of water yields stage 2.

B. Mass Balance
Sr.No Input Qty (Kg) Output Qty (Kg) Remarks
1 Valeronitrile 0.638 Toluene 0.02 Loss/Emission

2 Acetic acid 0.611 Methanol 0.022 Loss/Emission

3 Activated carbon 0.048 HCl 0.411 Scrubber

4 Caustic soda lye 1.36 DMF 0.019 Loss/Emission

5 Dimethyl Aqueous effluent To ETP

formamide
(Phosphoric
0.921 acid:1.114, 10.285
NaCl:2.092,
Water:9.789,
NaH2PO4:1.291)

6 Disodium EDTA Aqueous effluent To ETP

0.005 (Water:4.064, 0.154

Methanol:0.057,
NaCl:1.033)

7 Water Aqueous effluent To ETP

3.244 (Water:0.833, 0.886

Methanol:0.044,
NaCl:0.009)

8 Glycine Aqueous effluent To ETP

(Water:7.389,
Methanol:0.383,
NaHPO4:0.689,
NaOH:0.253,
0.543 Disodium 1.64
EDTA:0.005,
Sodium
acetate:0.834,
Organic
Imp.:0.087)

9 HCl (32%) 0.574 Spent carbon + To TSDF

0.485
Hyflo
10 Hyflo 0.006 Solid residue 0.522 To TSDF

11 Methanol Dimethylamine Recover/Recycle

0.9 0.485
HCl

12 NaOH solution DMF Recover/Recycle

3.919 0.454
(48%)

13 Phosphorous Methanol Recover/Recycle

3.396 0.74
oxychloride

14 Sodium Toluene Recover/Recycle

0.63 5.061
metabisulphite

15 Toluene 5.165 BCFI 0.776

Total 21.96 21.96

C. Process Flow Chart

Valeronitrile Toluene Emission/Loss

Acetic acid Methanol Emission/Loss

Activated carbon HCl Emission/Loss

Caustic soda lye DMF Emission/Loss

Dimethyl formamide Aqueous effluent To ETP

Disodium EDTA Aqueous effluent To ETP

Water Aqueous effluent To ETP

Glycine Stage 2 Aqueous effluent To ETP

HCl (32%) Spent carbon + Hyflo To TSDF

Hy flo Solid residue To TSDF

Methanol Dimethylamine HCl Recovery/Recycle

NaOH solution (50%) DMF Recovery/Recycle

Sodium metabisulphite Methanol Recovery/Recycle

Toluene Toluene Recovery/Recycle

Phosphorous oxychloride Stage 2

D. Route of Synthesis
 TTBB – N-(Triphenyl methyl) 5 – (4’ Bromomehyl biphenyl – zyl
Tetrazole)
A. Brief process of synthesis
Stage – 1
2-cyno 4’ methyl biphenyl is reacted with Sodium Azide in presence of ZnCl2 as catalyst and Di
Mehtyl Formamide as solvent medium. After reaction product TMB (Tetrazole Methyl
Biphyenyl) is precipitated by HCl, filtered & dried to get solid powder.

Stage – 2
TMB prepared in stage I is reacted with trityl chloride using ethylene dichloride as solvent
medium. After the reaction EDC is recovered and product formed TTMB and it is crystalized in
methanol, filtered & dried.

Stage – 3
TTMB made in stage II is reacted with Di bromo di methyl hydantoin in MDC as solvent medium.
After reaction the MDC is recovered & product is crystalized in ethyl acetate and is then filtered,
dried & packed as dry powder as TTBB.

B. Mass balance
Stage – 1

Sr. Input raw Quantity Quantity

Output Remark
no. material Kg/Batch Kg/Batch
Stage I
1 OTBN 100 TMB 120
product
Process loss
2 ZnCl2 200 25 Loss
in drying
Di Mehtyl
3 Sodium Azide 50 Formamide 380 recover
recover
Di Mehtyl
4 400 Loss 10 Loss
Formamide
Distillation
5 HCl 100 10 To CHWIF
residue
6 Water 600 Effluent 905 To ETP
TOTAL 1450 1450
Stage – 2

Sr. Input raw Quantity Quantity

Output Remark
no. material Kg/Batch Kg/Batch
Stage II
1 TMB (stage I) 120 TTMB 240
product
Process loss
2 EDC 1200 26 Loss
in drying
3 Trityl chloride 146 EDC recover 1140 Recover
4 Methanol 96 Loss 30 Loss
Distillation
30 To CHWIF
residue
Distilled &
Methanol ML 91
reused
Loss 3 Loss
Distillation
2 To CHWIF
residue
TOTAL 1562 1562

Stage – 3

Sr. Input raw Quantity Quantity

Output Remark
no. material Kg/Batch Kg/Batch
Final
1 TTMB (stage II) 240 TTBB 196
product

2 MDC 1050 MDC Recover 996.5 Recover

Di bromo di
3 78 Loss 14.5 Loss
methyl hydantoin
Distillation
4 Ethyl acetate 349 59 To CHWIF
residue
Process loss
22 Loss
in drying
Ethyl acetate
331 Recover
Recover
Loss 59 Loss
Distillation
39 To CHWIF
residue
TOTAL 1717 1717
 C. Route of Synthesis

Stage – 1

Stage – 2

Stage – 3
 Ethyl-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-
carboxylate

A. Brief process of synthesis

To a 3M solution of Methyl magnesium chloride in Tetrahydrofuran was added a

solution of diethyl 2-propyl imidazole- 4,5-dicarboxylate in Tetrahydrofuran at -10 to
0°C under N2 atmosphere. The mixture was stirred at -5 to 0°C for 10 minutes. Reaction
mass was quenched into 25 % ammonium chloride solution followed by extraction with
ethyl acetate. The organic phase was separated, washed with brine and concentrated in
vacuo to give a syrup, which was crystallized using Diisopropyl ether. Filter it and dry
at 50-60°C for 10-12 Hrs.

B. Mass balance

Sr.No. Input kgs Output kgs

1. diethyl 2-propyl-1H- 250 Ethyl-4-(1-hydroxy-1-methyl 225
imidazole ethyl)-2-propylimidazole-5-
-4,5-dicarboxylate carboxylate
2. Methyl magnesium chloride 275 Tetra hydro furan recovered 960
3. Tetra hydro furan 1000 Ethyl acetate recovered 710
4. Ammonium chloride 750 Diisopropyl ether recovered 450
solution 25%
5. Ethyl acetate 750 Magnesium chloride 59
6. Diisopropyl ether 500 Carbon monoxide 27.5
7. Effluent 1058.5
Drying loss 35
Total 3525 3525
 C. Process flow diagram

Flow Diagram of Ethyl-4-(1-hydroxy-1-methyl ethyl)-2-propylimidazole-5-carboxylate

Reactor
diethyl 2-propyl-1H-imidazole
-4,5-dicarboxylate (250 KGS) THF recover (960 kgs)
THF (1000 KGS) ETHYL ACETATE recover (710 kgs)
Methyl magnesium chloride (275 kgs) magnesium chloride (59 kgs)
AMMONIUM CHLORIDE SOLUTION
(750 KGS) Diisopropyl ether recovered (450 kgs)
ETHYL ACETATE (750 kgs) CARBON MONOXIDE (27.5 KGS)
dieisopropyl ether (500 kgs)

Centrifuge
effluent (1058.5 kgs)

w/c, Dryer
drying loss (35 kgs)

Ethyl-4-(1-hydroxy-1-methyl ethyl)-2-
propylimidazole-5-carboxylate: 320 KGS

D. Reaction Chemistry
 2-Nitro-4-thiocyanoaniline

A. Brief process of synthesis

2-Nitroaniline was treated with ammonium thiocyanate in methanol at room temperature.

The reaction mixture was stirred and cooled to below 10°C. Chlorine gas was purged and
maintained. After completion of the reaction, water was added and stirred at 20°C. The
reaction mass was filtered, washed with water, and dried.

B. Mass Balance

Sr. Quantity Quantity

Input Output Remark
No. (KG/Batch) (KG/Batch)
2-nitro p- Thio
1 2-Nitro Aniline 360 504 Stage-1
cyano aniline
Ammonium Methanol Reuse in
2 407 740
thiocyanate recover process
3 Methanol 750 Loss of vapour 10
4 Chlorine gas 185 Effluent 633 To ETP
Pass
through
5 Water 200 Drying loss 15 Activated
carbon
column
Total 1902 1902
 C. Process flowchart

Flow Diagram of Albendazole (stage-1)

Methanol (750 kg) GLRReactor Methanol recover(740 kg)
2-Nitro Aniline (360 kgs) loss (10 kg)
Ammonium thiocyanate (470 kgs)
Chlorine gas

WATER (200 kg) Centrifuge

waste water (633 kg)

2-Nitro-p-thio
cyanoaniline wet cake

Dryer Drying loss (15 kg)

2-Nitro-p-thio
cyanoaniline 504 kgs

D. Chemical Reaction
 2-Chlorotrityl Chloride
A. Brief Process of Synthesis

Otho-Chlorobenzotrichloride is reacted with Benzene in presence of Aluminium

chloride, Hydrochloric acid, Toluene and Hexane to obtain 2-Chlorotrityl Chloride.

B. Mass Balance

Sr. Quantity Quantity

Input Output Remarks
No. (kg) (kg)
2-Chlorotrityl Chloride
1 Ortho- Chlorobenzotrichloride 350 2-Chlorotrityl Chloride 350
Benzene recovered 779
2 Benzene 900 Re-use
Vapour loss 56
3 Aluminium Chloride 385
4 Hydrochloric acid 30% 700 To ETP
Ammonical Aq. ML with organic traces 3525
4 Water 2100
5 Sodium Chloride 210
5 Toluene 140
Toluene + Hexane recovered 1290
5 Hexane 1375 Re-use
Vapour loss 110
7 Distillation residue 50 To CHWIF
Total 6160 6160

C. Flow Diagram
1. o-chlorobenzotrichloride
2. Aluminium Chloride
3. Benzene Hydrogen Chloride
4. Hydrochloric acid
5. Water
6. Sodium Chloride 6 KL GLR Aqueous ML
with acidic pH

1. Toluene
2. Hexane Benzene

3 KL SSR/GLR
Organic layer
Hexane

Toluene + Hexane
Centrif uge mixture
36" Dia
Mother Liquor

Distillation
2-Chlorotrityl Chloride Residue

D. Route of Synthesis
 Cl
Cl

Cl
+ 2

Cl

Benzene
Ortho chlorobenzotrichloride Molecular Weight: 78.11
Molecular Weight: 229.92

229.92+2X78.11=386.14

AlCl3

Cl

+ 2 HCl

Cl
2-Chlorotrityl Chloride Hydrochloric acid
Molecular Weight: 313.22 Molecular Weight: 36.46
 L-Valine methyl ester hydrochloride
A. Brief process of synthesis
L‐ Valine is treated with methanol in presence of Thionyl chloride, stir at 65-70°C for
10-12 hrs. to get L‐ Valine methyl ester, distilled out Methanol, which was then
neutralized with alkali solution to get L‐methyl valinate, filter and dry at 55-65°C for
10-12 hrs.

B. Mass balance

Sr.No. Input kgs Output kgs

1. L-Valine 450 L-Valine methyl ester
625
hydrochloride
2. Methanol 1800 Methanol recovered 1680
3. Thionyl chloride 350 MDC recovered 1440
4. Water 1350 Sulfur dioxide 246
5. Sodium hydroxide 350 Hydrochloric acid 50
6. MDC 1500 Effluent 1709
7. Drying loss 25
8. residue 25

Total 5800 5800

C. Process flow diagram

Flow Diagram of L-Valine methyl ester Hydrochloride

Reactor
L-Valine (450 kgs)
thionyl chloride (350 kgs) Methanol recover (1780 kgs)
Water (1350 kgs) SULFUR DIOXIDE (246 kgs)
methanol (2000 kgs) Hydrochloric acid (140 kgs)
sodium hydroxide (350 kgs) effluent (1709 kgs)
MDC (1500 KGS)

Centrifuge REACTOR:
ML MDC recovered (1440 kgs)
Distillation
Residue (25 kgs)

w/c, Dryer
drying loss (35 kgs)

L-Valine methyl ester Hydrochloride: 320 KGS

D. Reaction Chemistry
 Bis(2-chloroethyl)amine Hydrochloride

A. Brief process of synthesis

Diethanol amine react with thionyl chloride using chloroform then IPA HCl getting product
after centrifuge and drying

B. Mass Balance

Sr. Quantity Quantity

Input Output Remark
No. (KG/Batch) (KG/Batch)
Bis(2-chloroethyl)
Final
1 Diethanol amine 500 amine 800
product
hydrochloride
Reuse in
2 Thionyl chloride 1100 Chloroform recover 475 the
process
3 Chloroform 500 Loss 25
Reuse in
4 IPA HCl 680 IPA recover 600 the
process
5 Loss 25
6 Residue 25 To CHWIF
To
7 HCl gas 300
Scrubber
To
8 SO2 gas 500
Scrubber
Pass
through
9 Drying loss 30 Activated
carbon
column.
Total 2780 2780
 C. Process flowchart

Flow Diagram of Bis(2-chloroethyl)amine hydrochloride

diethanol amine(500 kg) Reactor Chloroform recover(475 kg)

Thionyl chloride(1100 kg) LOSS (25 kg)
Chloroform(500 kg) IPA recover (600 kg)
IPA HCl (680 kg) LOSS (25 kg)
residue (25 kg)
SO2 gas (500 kg)
HCl gas (300 kg)

Centrifuge

w/c, Dryer
loss (30 kg)

Bis(2-chloroethyl)amine hydrochloride: 800 KGS

D. Route of Synthesis
 Diethyl amino ethyl chloride hydrochloride

A. Brief process of synthesis

Charge di ethyl amino ethanol and EDC, ADDED Thionyl chloride and stir for 10-12 hrs.
at 70-750C. Distilled out EDC and then added water ,cool to 5-100C and filter it, dry at
45-500C for 6-8 Hrs.

B. Mass balance

Sr.No. Input kgs Output kgs

1. Diethyl amino ethanol 234 Diethyl amino ethyl 225
chloride HCl
2. Thionyl chloride 162 Sulfur dioxide 128
3. EDC 500 EDC recovered 480
4. WATER 500 Drying loss 40
5. effluent 523
Total 1396 1396

C. Process flow diagram

Flow Diagram of Diethyl amino ethyl chloride hydrochloride

Reactor
diethyl amino ethanol (234 kgs) EDC recover (480 kgs)
thionyl chloride (162 kgs) SULFUR DIOXIDE (128 kgs)
EDC (500 KGS)
Water (500 kgs)

centrifuge
effluent (523 kgs)

w/c, dryer
drying loss (40 kgs)

Diethyl amino ethyl chloride hydrochloride: 225 KGS

D. Reaction Chemistry
 Dimethyl amino ethyl chloride hydrochloride

A. Brief process of synthesis

Charge dimethyl amino ethanol and EDC, Added Thionyl chloride and stir for 8-10 hrs.
At 70-750C. Distilled out EDC and then added water ,cool to 5-100C and filter it, dry at
45-500C for 6-8 Hrs.

B. Mass balance

Sr.No. Input kgs Output kgs

1. Dimethyl amino ethanol 750 Dimethyl amino ethyl 800
chloride HCl
2. Thionyl chloride 650 Sulfur dioxide 539
3. EDC 1000 EDC recovered 970
4. WATER 350 Drying loss 55
5. effluent 386
Total 2750 2750

C. Process flow diagram

Flow Diagram of Dimethyl amino ethyl chloride hydrochloride

Reactor
dimethyl amino ethanol (750 kgs) EDC recover (970 kgs)
thionyl chloride (650 kgs) SULFUR DIOXIDE (539 kgs)
EDC (1000 KGS)
Water (350 kgs)

centrifuge
effluent (386 kgs)

w/c, dryer
drying loss (55 kgs)

Dimethyl amino ethyl chloride hydrochloride: 800 KGS

D. Reaction Chemistry
 Dimethyl amino propyl chloride hydrochloride

A. Brief process of synthesis

Charge dimethyl amino propanol and EDC, ADDED Thionyl chloride and stir for 12-14
hrs. at 75-800C. Distilled out EDC and then added water ,cool to 5-100C and filter it, dry
at 50-550C for 10-12 Hrs.

B. Mass balance

Sr.No. Input kgs Output kgs

1. Dimethyl amino propanol 500 Dimethyl amino propyl 600
chloride HCl
2. Thionyl chloride 630 Sulfur dioxide 310
3. EDC 1200 EDC recovered 1160
4. WATER 500 Drying loss 45
5. effluent 715
2830 2830

C. Process flow diagram

Flow Diagram of Dimethyl amino propyl chloride hydrochloride

Reactor
dimethyl amino propanol (500 kgs) EDC recover (1160 kgs)
thionyl chloride (630 kgs) SULFUR DIOXIDE (310 kgs)
EDC (1200 KGS)
Water (500 kgs)

centrifuge
effluent (715 kgs)

w/c, dryer
drying loss (45 kgs)

Dimethyl amino propyl chloride hydrochloride : 600 KGS

D. Reaction Chemistry
 4-(Aminomethyl) Benzoic Acid

A. Brief process of synthesis

Step 1
P toluic acid and N bromo succinamide react in Mono Chloro benzene as solvent at 90 0C
to form P bromo methyl benzoic acid.

Step 2

P bromo methyl amino benzoic acid reacts with potassium phthalamide in ethanol as
solvent at reflux temperature to give P amino methyl benzoic acid and Phthalic acid.

B. Mass balance:
Kg/Batch Kg/batch
INPUT OUTPUT
Stage-1
Para toluic acid 86.6 Stage-1 136.8

N bromo succinamide 113.2 Succinamide 63

Mono Chloro benzene 300 Mono Chloro benzene 250

Spent Solvent 50
Total 499.8 Total 499.8

Stage-2
Stage-1 136.8 4-(Aminomethyl) 169
Benzoic Acid
Potassium 117.8 Phthalic acid 105.6
phthalamide
Ethanol 150 Waste water 230
DM Water 250 Ethanol 120
Spent Ethanol 30
Total 654.6 Total 654.6

C. Process Flow Chart

 D. Route of Synthesis
Step 1: Preparation of P-Bromo methyl benzoic acid

P Toluic acid N-Bromo succinamide P-Bromo methyl benzoic acid

Succinamide (M.W:136.15) (M.W:177.98) (M.W:215.04)
(M.W:99.09)

Step 2: Preparation of P monomethyl benzoic acid

P-bromo methyl Potassium phthalamide Water P-Amino methyl BA Phthalic acid Potasium

Benzoic acid Bromide

(M.W:215.04) (M.W:185.23) (M.W 18.015) (M.W:151.16) (M.W: 166.14) (M.W. 119)

4. 5-Difluoromethoxy-2-{[(3,4- dimethoxy-2- pyridinyl)methyl]thio}-
1Hbenzimidazole:

Sr. No Product Name CAS NO. Molecular

weight
5-Difluoromethoxy-2-{[(3,4-
dimethoxy-2-
pyridinyl)methyl]thio}-
1 1Hbenzimidazole

Maltol 118-71-8 126

Dimethyl sulphate 77-78-1 126.13

Potassium carbonate 584-08-7 138

Acetone 67-64-1 58.08

Ammonium Carbonate 506-87-6 96

Toluene 108-88-3 92.14

Water 7732-18-5 18.02

Phosphorous oxy chloride 10025-87-3 153.5

Sodium Hydroxide 1310-73-2 39.99

Methylenedichloride 75-09-2 84.93

Hydrogen peroxide (30%) 7722-84-1 34.01

Acetic acid 64-19-7 60.05

Methanol 67-56-1 32.04

Acetic Anhydride 108-24-7 102

Chloroform 67-66-3 119.38

Thionyl chloride 7719-09-7 118.97

5-diFluoromethoxy-2-
mercapto- benzimidazole 97963-62-7 216

Sodium hypochlorite (12%) 7681-52-9 74.5

n-Hexane 110-54-3 86.18

Ammonium Chloride 12125-02-9 53.49

Activated Carbon 7440-44-0 12.01

Process :

Stage :1 Maltol is reacted with Diemthyl Sulfate in presence of Potassium Carbonate in

Acetone solvent media to get (Stage-1) Compound.

Stage :2 Stage 1 compound is reacted with Ammonium Carbonate in presence of Toluene to

get Stage-2 Compound.

Stage :3 Stage 2 compound is reacted with Phosphorus Oxychloride in presence of

Methylene Dichloride to get (Stage-3) compound

Stage :4 Stage-3 compound is reacted with Hydrogen Peroxide to get Stage-4 Compound.

Stage :5 Stage-4 compound is reacted with Sodium hydroxide in presence of Methanol to get
Stage-5 Compound.

Stage :6 Stage-5 compound is reacted with Acetic Anhydride to get Stage-6 Compound.

Stage :7 Stage-6 compound is reacted with Sodium Hydroxide in presence of Methylene

Dichloride to get Stage-7 Compound.

Stage :8 Stage-7 compound is reacted with Thionyl Chloride in presence of Chloroform and
Methanol to get Stage-8 Compound.

Stage :9 Stage-8 compound is reacted with (5-Difluoromethoxy)-2-mercapto Benzimidazole

and Sodium Hydroxide in presence of Methylene dichloride to get Stage-9 Compound.

Reaction :
Stage 1: Preparation of 3 methoxy 2- methyl 4- pyrone

Stage 2: Preparation of 3 –Methoxy 2-methyl 4- pyridine

Stage 3: Preparation of 3 –methoxy 2- methyl 4-chloro pyridine

Stage 4: Preparation of 3 methoxy 2-methyl 4- chloro pyridine N oxide

Stage 5: Preparation of 3, 4 dimethoxy 2- methyl pyridine N oxide

Stage 6: Preparation of 2- Acetoxy methyl 3,4 –dimethoxy pyridine

Stage 7: Preparation of 2-hydroxy methyl 3, 4-dimethoxy pyridine

Stage 8: Preparation of 2- chloromethyl dimethoxy pyridine HCL

Stage 9: Preparation of 5 (difluoromethoxy) 2- [[[3 4 dimethoxy 2-
pyridinyl]methyl’thio]-1H-benzimidazole
Flow Chart:

Maltol : 85 Kg Acetone recover:310 Kg

Potassium Carbonate : 55 Kg Reaction Acetone loss :25 Kg
Acetone : 325 kg Process emission :10 Kg
Dimethyl Sulfate : 45 Kg

Effluent Water : 6Kg

Centrifuge Organic residue: 24 Kg
Inorganic residue:50 Kg

Ammoniun Carbonate : 65 Kg Toluene Recover : 185 Kg

Toluene : 215 Kg Reaction Tolune loss: 20 Kg
Water: 355.40 kg Process emission: 27 Kg

Centrifuge Effluent Water : 394 Kg

Organic Residue: 19 Kg
Posphorus Oxychloride :35 Kg
Ethylene Dichloride: 360 kg
Ethylene Dichloride recover: 338 Kg
Water : 202.09 kg Reaction Ethylene Dichloride loss:15 Kg
Sodium hydroxide: 10 Kg

Effluent Water : 237.08 Kg

Centrifuge
Organic residue :17 kg

Hydrogen Peroxide : 40 kg
n-Hexane : 400Kg Methylene dichloride recover: 418 Kg
Methylene dichloride loss : 15 Kg
MDC: 440 KG Reaction
n-hexane recover: 378 Kg
Acetic acid: 40 kg
n-Hexane loss :16 kg
Sodium Hydroxide :22 Kg
Water : 122.64 Kg
Effluent Water : 216 Kg
Centrifuge Organic residue: 21 Kg

Sodium methoxide : 23 Kg Methanol : 169.15 Kg

Methanol : 180 Kg Reaction Methanol Loss: 10 Kg

Organic residue: 8.85 Kg

Centrifuge Inorganic residue:25 Kg

Acetic acid recover: 21 Kg

Acetic Anhydride: 40 Kg Reaction
Acetic acid loss: 1 Kg

Distillation residue
Centrifuge
residue:8 Kg
Sodium Hydroxide : 15 kg
Methylene Dichloride : 275 Kg Methylene dichloride recover: 260Kg
Water: 101.74 Kg Reaction Methylene Dichloride loss:11 Kg

Effluent water: 131.74 Kg

Centrifuge:
Organic residue: 9 Kg

Thionyl Chloride: 39 Kg Acetone recover: 119 Kg

Toluene: 190 Kg Reaction Acetone loss:8 Kg
Acetone : 130 kg Toluene recover:170 Kg
Toluene loss:15 kg
Process emission :21 Kg

Centrifuge Organic residue: 16 kg

2DFMB : 70 Kg
Sodium Hydroxide: 25 kg Toluene recover: 173 Kg
Toluene: 185 Kg Reaction
Toluene loss: 8 Kg
Water : 418.11 Kg

Water effluent: 464.118 Kg

Centrifuge
Organic residue: 18 Kg

5-Difluoromethoxy-2-{[(3,4- dimethoxy-2-
pyridinyl)methyl]thio}-1Hbenzimidazole:- 100 Kg
Mass balance :
Input material Kg/Batch Output material Kg/Batch
Stage-1
Maltol 85 Stage-1 85
Potassium carbonate 55 Acetone Recovery 310 Reuse
Acetone 325 Acetone loss 25
Dimethyl sulphate 45 Carbon dioxide gas 10 Scrubber
Waste water 6 ETP
Inorganic Residue 50
Organic Residue 24
Total 510 Total 510

Stage-2
Stage-1 85 Stage-2 75
Ammonium 65 Toluene Recovery 185 Reuse
Carbonate
Toluene 215 Toluene Loss 20
Water 355.40 Carbon dioxide gas 27
Wastewater 394.4 ETP
Organic Residue 19
Total 720.4 Total 720.4

Stage-3
Stage-2 75 Stage-3 75

Phosphorous oxy 35 Organic Residue 17

chloride
Sodium Hydroxide 10 Waste water 237.08
Ethelene Dichloride
Ethylene dichloride 360 338 Reuse
recovery
202.09 Ethelene Dichloride 15
Water Loss
Total 682.09 Total 682.09

Stage-4
Stage-3 75 Stage-4 75
Hydrogen peroxide 40 Methylenedichloride 418
(30%) Recovery
400 Methylenedichloride 15
n-Hexane Loss
Methylenedichloride 440 n-Hexane recovery 378
Acetic acid 40 n-Hexane Loss 16
Sodium Hydroxide 22 Wastewater 216.64
Water 122.648 Organic Residue 21
Total 1139.64 Total 1139.64
 Stage-5
Stage-4 75 Stage-5 65
Sodium Methoxide 23 Methanol recover 169.15
Methanol 180 Methanol losss 10
Organic Residue 8.85
Inorganic Residue 25
Total 278 Total 278

Stage-6
Stage-5 65 Stage-6 75
Acetic Anhydride 40 Acetic Acid Recovery 21 Reuse
Acetic Acid Loss 1
Distilation Residue 8
Total 105 Total 105

Stage-7
Stage-6 75 Stage-7 55
Methylenedichloride Reuse
Sodium Hydroxide 15 Recover 260
Methylenedichloride
Methylenedichloride 275 Loss 11
Water 101.74 Waste Water 131.74
Organic Residue 9
Total 466.74 Total 466.74

Stage-8
Stage-7 55 Stage-8 65
Thionyl chloride 39 Acetone Recover 119
Toluene 190 Aceton Loss 8
Acetone 130 Toluene Recover 170
Toluene Loss 15
Sulphur dioxide gas 21
Organic Residue 16
Total 414 Total 414

Stage-9
5-Difluoromethoxy-2-
{[(3,4- dimethoxy-2-
Stage-8 65 100
pyridinyl)methyl]thio}-
1Hbenzimidazole
5-diFluoromethoxy-
2- mercapto- 70 Toluene Recover 173
benzimidazole
Sodium Hydroxide 25 Toluene Loss 8
Toluene 185 Waste Water 464.118
Water 418.12 Organic Residue 18
Total 763.11 Total 763.11
 2-Chloromethyl 3,4-Dimethoxy Pyridine HCl
Process :

Stage :1 Maltol is reacted with Diemthyl Sulfate in presence of Potassium Carbonate in

Acetone solvent media to get (Stage-1) Compound.

Stage :2 Stage 1 compound is reacted with Ammonium Carbonate in presence of Toluene to

get Stage-2 Compound.

Stage :3 Stage 2 compound is reacted with Phosphorus Oxychloride in presence of

Methylene Dichloride to get (Stage-3) compound

Stage :4 Stage-3 compound is reacted with Hydrogen Peroxide to get Stage-4 Compound.

Stage :5 Stage-4 compound is reacted with Sodium hydroxide in presence of Methanol to get
Stage-5 Compound.

Stage :6 Stage-5 compound is reacted with Acetic Anhydride to get Stage-6 Compound.

Stage :7 Stage-6 compound is reacted with Sodium Hydroxide in presence of Methylene

Dichloride to get Stage-7 Compound.

Stage :8 Stage-7 compound is reacted with Thionyl Chloride in presence of Chloroform and
Methanol to get Stage-8 Compound.

Reaction :
Stage 1: Preparation of 3 methoxy 2- methyl 4- pyrone

Stage 2: Preparation of 3 –Methoxy 2-methyl 4- pyridine

Stage 3: Preparation of 3 –methoxy 2- methyl 4-chloro pyridine

Stage 4: Preparation of 3 methoxy 2-methyl 4- chloro pyridine N oxide

Stage 5: Preparation of 3, 4 dimethoxy 2- methyl pyridine N oxide

Stage 6: Preparation of 2- Acetoxy methyl 3,4 –dimethoxy pyridine

Stage 7: Preparation of 2-hydroxy methyl 3, 4-dimethoxy pyridine

Stage 8: Preparation of 2- chloromethyl dimethoxy pyridine HCL

Flow Chart:

Maltol : 85 Kg Acetone recover:290 Kg

Potassium Carbonate : 55 Kg Reaction Acetone loss :18 Kg
Acetone : 305 kg Process emission :15 Kg
Dimethyl Sulfate : 45 Kg

Effluent Water : 6Kg

Centrifuge Organic residue: 24 Kg
Inorganic residue:67 Kg

Ammoniun Carbonate : 65 Kg Toluen Recover : 190 Kg

Toluene : 215 Kg Reaction Tolune loss: 15 Kg
Water: 355.4 kg Process emission: 27 Kg

Centrifuge Effluent Water : 394Kg

Organic Residue: 19 Kg
Posphorus Oxychloride :35 Kg
Ethylene Dichloride: 360 kg
Ethylene Dichloride recover: 338 Kg
Water : 202.09 kg Reaction Ethylene Dichloride loss:15 Kg
Sodium hydroxide: 10 Kg

Effluent Water : 237.08 Kg

Centrifuge
Organic residue :17 kg

Hydrogen Peroxide : 40 kg
Methylene dichloride recover: 209 Kg
n-Hexane : 400Kg
Methylene dichloride loss : 9 Kg
MDC: 220 KG Reaction
n-hexane recover: 378 Kg
Acetic acid: 40 kg
n-Hexane loss :11 kg
Sodium Hydroxide :22 Kg
Water : 122.64 Kg
Effluent Water : 216 Kg
Centrifuge Organic residue: 21 Kg

Sodium methoxide : 23 Kg Methanol : 169.15 Kg

Methanol : 180 Kg Reaction Methanol Loss: 10 Kg

Organic residue:16 Kg
Centrifuge Inorganic residue:25 Kg

Acetic acid recover: 21 Kg

Acetic Anhydride: 40 Kg Reaction
Acetic acid loss: 1 Kg
 Distillation residue
Centrifuge
residue:8 Kg

Sodium Hydroxide : 15 kg
Methylene Dichloride : 175 Kg Methylene dichloride recover: 160Kg
Water: 101.7 Kg Reaction Methylene Dichloride loss:11 Kg

Effluent water: 131.74 Kg

Centrifuge:
Organic residue: 9 Kg

2-Chloromethyl 3,4-
Thionyl Chloride: 39 Kg
Dimethoxy Pyridine HCl 65Kg
Toluene: 210 Kg Reaction Acetone recover: 119 Kg
Acetone : 130 kg
Acetone loss:8 Kg
Toluene recover: 195 Kg
Toluene loss:10 kg
Process emission :21 Kg

Centrifuge Organic residue: 16 kg

Mass balance :

Input material Kg/Batch Output material Kg/Batch

Stage-1
Maltol 85 Stage-1 85
Potassium carbonate 55 Acetone Recovery 290 Reuse
Acetone 305 Acetone loss 18
Dimethyl sulphate 45 Carbon dioxide gas 15 Scrubber
Waste water 6 ETP
Inorganic Residue 52
Organic Residue 24
Total 490 Total 490

Stage-2
Stage-1 85 Stage-2 75
Ammonium 65 Toluene Recovery 190 Reuse
Carbonate
Toluene 215 Toluene Loss 15
Water 355.40 Carbon dioxide gas 27
Wastewater 394.4 ETP
Organic Residue 19
Total 720.4 Total 720.4

Stage-3
Stage-2 75 Stage-3 75

Phosphorous oxy
35 Organic Residue 17
chloride
Sodium Hydroxide 10 Waste water 237.08
Ethelene Dichloride
Ethylene dichloride 360 338 Reuse
recovery
Ethelene Dichloride
Water 202.09 Loss 15
Total 682.09 Total 682.09

Stage-4
Stage-3 75 Stage-4 75

Hydrogen peroxide Methylenedichloride 209

40 Recovery
(30%)
400 Methylenedichloride 9
n-Hexane Loss
Methylenedichloride 220 n-Hexane recovery 378

Acetic acid 40 n-Hexane Loss 11

Sodium Hydroxide 22 Wastewater 216.64

122.648 Organic Residue 21

Water
Total 919.64 Total 919.64

Stage-5
Stage-4 75 Stage-5 65
Sodium Methoxide 23 Methanol recover 169.15
Methanol 180 Methanol losss 10
Organic Residue 8.85
Inorganic Residue 25
Total 278 Total 278

Stage-6
Stage-5 65 Stage-6 75
Acetic Acid 21 Reuse
Acetic Anhydride 40 Recovery
Acetic Acid Loss 1
Distilation Residue 8
Total 105 Total 105

Stage-7
Stage-6 75 Stage-7 55
Methylenedichloride 160 Reuse
Sodium Hydroxide 15 Recover
Methylenedichloride
Methylenedichloride 175 Loss 11
Water 101.74 Waste Water 131.74
Organic Residue 9
Total 366.74 Total 366.74

Stage-8
2-Chloromethyl 3,4-
Stage-7 55 Dimethoxy Pyridine 65
HCl
Thionyl chloride 39 Acetone Recover 119
Toluene 210 Aceton Loss 8
Acetone 130 Toluene Recover 195
Toluene Loss 10
Sulphur dioxide gas 21
Organic Residue 16
Total 434 Total 434
 2-chloromethyl-4-(3-methoxy propoxy)-3-methylpyridine
hydrochloride

A. Brief process of synthesis

Stage-1:
4-Chloro-2,3-dimethylpyridine-N-oxide hydrochloride is condensed with 3-methoxy-1-
propanol and rearranged with acetic anhydride and is hydrolyzed with sodium
hydroxide stir for 4-6 hrs. at 90-950C and is neutralized with dry HCl to give 2-
hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride. dry at 8-10
hrs.at50-500C.

Stage-2:
2-Hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride is reacted
with thionyl chloride, stir for 10-12 hrs. at 75-800C to give 2-chloro methyl-4-(3-
methoxypropoxy)-3-methyl pyridine hydrochloride. cool to 5-100C and filter it, dry at
50-550C for 10-12 Hrs.

B. Mass balance
Stage-1: 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine
hydrochloride

Sr.No. Input kgs Output kgs

1. 4-Chloro-2,3-dimethyl 240 2-hydroxymethyl-4-(3- 240
pyridine-N-oxide methoxy propoxy)-3-
hydrochloride methyl pyridine
hydrochloride
2. 3-methoxy propanol 130 MDC recovered 940
3. MDC 1000 Hydrochloric acid 44.5
4. SODIUM HYDROXIDE 200 Drying loss 25
5. TBAB 6 effluent 926.5
6. Conc.HCl 100
7. water 500
Total 2176 2176
 C. Process flow diagram

Flow Diagram of 2-chloromethyl-4-(3-methoxy propoxy)-3-methylpyridine hydrochloride

4-Chloro-2,3-dimethyl pyridine-N-oxide Reactor

hydrochloride(240 kgs) MDC recovered (940 kgs)
3-methoxy propanol (130 kgs) hydrochloric acid (44.5 kgs)
Water (500 kgs)
sodium hydroxide (200 kgs)
MDC (1000 KGS)
TBAB (6 KGS)
Conc.HCl (100 kgs)

Centrifuge
effluent (926.5 kgs)

wet cake/ drying loss (25 kgs)

dryer

2-hydroxymethyl-4-(3-methoxy propoxy)-
3-methyl pyridine hydrochloride :240 KGS

Reactor
stage-1 (240 kgs)
Toluene (680 kgs) toluene recover (640 kgs)
Thionyl chloride (115 kgs) hydrochloric acid (35.7 kgs)
water (500 kgs) sulfur dioxide (62.1 kgs)

Centrifuge
effluent (512.2 kgs)

wet cake
drying loss (35 kgs)

2-chloromethyl-4-(3-methoxy propoxy)-
3-methylpyridine hydrochloride :250 KGS
D. Reaction Chemistry
 [[(4-(3-methoxypropoxy)-3-methyl- 2-pyridinyl) methyl] thio]-1H-
benzimidazole

A. Brief process of synthesis

Stage-1:
4-Chloro-2,3-dimethylpyridine-N-oxide hydrochloride is condensed with 3-methoxy-1-
propanol and rearranged with acetic anhydride and is hydrolyzed with sodium
hydroxide stir for 4-6 hrs. at 90-950C and is neutralized with dry HCl to give 2-
hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride. dry at 8-10
hrs. at 50-500C

Stage-2:
2-Hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride is reacted
with thionyl chloride, stir for 10-12 hrs. at 75-800C to give 2-chloro methyl-4-(3-
methoxypropoxy)-3-methyl pyridine hydrochloride. cool to 5-100C and filter it, dry at
50-550C for 10-12 Hrs.

Stage-3:
2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride is condensed
with 2-mercapto-1H-benzimidazole,stir for 4-6 hrs. at 45-550C to give 2-[[(4-(3-
methoxypropoxy)-3-methyl- 2-pyridinyl)methyl] thio]-1H-benzimidazole. cool to 15-
200C and filter it, dry at 60-650C for 12 Hrs.

B. Mass balance
Stage-1:
2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride

Sr.No. Input kgs Output kgs

1. 4-Chloro-2,3-dimethyl 240 2-hydroxymethyl-4-(3- 240
pyridine-N-oxide methoxy propoxy)-3-methyl
hydrochloride pyridine hydrochloride
2. 3-methoxy propanol 130 MDC recovered 940
3. MDC 1000 Hydrochloric acid 44.5
4. SODIUM HYDROXIDE 200 Drying loss 25
5. TBAB 6 effluent 926.5
6. Conc.HCl 100
7. water 500
Total 2176 2176
 Stage-2:
2-chloromethyl-4-(3-methoxy propoxy)-3-methylpyridine hydrochloride
Sr.No. Input kgs Output kgs
1. 2-hydroxymethyl-4-(3- 240 2-chloromethyl-4-(3- 250
methoxy propoxy)-3- methoxy propoxy)-3-
methyl pyridine methylpyridine
hydrochloride hydrochloride
2. Toluene 680 Toluene recovered 640
3. Thionyl chloride 115 Hydrochloric acid 35.7
4. water 500 Sulfur dioxide 62.1
5. Drying loss 35
6. effluent 512.2
1535 1535

Stage-3:
2-[[(4-(3-methoxypropoxy)-3-methyl- 2-pyridinyl) methyl] thio]-1H-
benzimidazole

Sr.No. Input kgs Output kgs

1. 2-chloromethyl-4-(3- 250 2-[[(4-(3- 280
methoxy propoxy)-3- methoxypropoxy)-3-
methylpyridine methyl- 2-pyridinyl)
hydrochloride methyl] thio]-1H-
benzimidazole
2. 2-mercapto-1H-benzo [d] 154 Hydrochloric acid 68.6
imidazol-6-ylium
3. Water 1000 Drying loss 35
4. effluent 1020.4
Total 1404 1404
 C. Process flow diagram

Flow Diagram of 2-chloromethyl-4-(3-methoxy propoxy)-3-methylpyridine hydrochloride

4-Chloro-2,3-dimethyl pyridine-N-oxide Reactor

hydrochloride(240 kgs) MDC recovered (940 kgs)
3-methoxy propanol (130 kgs) hydrochloric acid (44.5 kgs)
Water (500 kgs)
sodium hydroxide (200 kgs)
MDC (1000 KGS)
TBAB (6 KGS)
Conc.HCl (100 kgs)

Centrifuge
effluent (926.5 kgs)

wet cake/ drying loss (25 kgs)

dryer

2-hydroxymethyl-4-(3-methoxy propoxy)-
3-methyl pyridine hydrochloride :240 KGS

Reactor
stage-1 (240 kgs)
Toluene (680 kgs) toluene recover (640 kgs)
Thionyl chloride (115 kgs) hydrochloric acid (35.7 kgs)
water (500 kgs) sulfur dioxide (62.1 kgs)

Centrifuge
effluent (512.2 kgs)

wet cake
drying loss (35 kgs)

2-chloromethyl-4-(3-methoxy propoxy)-
3-methylpyridine hydrochloride :250 KGS
 Flow Diagram of 2-[[(4-(3-methoxypropoxy)-3-methyl- 2-pyridinyl) methyl] thio]-1H-benzimidazole (final)

Reactor
stage-2 (250 kgs)
2-mercapto-1H-benzo [d] imidazol-6-ylium
(150 kgs) hydrochloric acid (68.6 kgs)
water (1000 kgs)

Centrifuge
effluent (1020.4 kgs)

wet cake/
dryer drying loss (35 kgs)

2-[[(4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)
methyl] thio]-1H-benzimidazole :280 KGS
D. Reaction Chemistry
 Chloro acetyl Xylidine

A. Brief process of synthesis

Take 2.6, Xylidine and soda ash, stirring well maintaining temperature of 20- 25 ⁰C.
Then start addition of Chloro Acetyl Chloride under stirring at low temperature. Stir for
4 hrs. at 5-100C. After this, add Toluene to this reaction mass. The mass is filtered to get
intermediate product Chloro Acetyl Xylidine. The toluene separated from the filtration
stage is recycled back for next batch required make up quantity of Toluene is added.
The Chloro Acetyl Xylidine is dry at 45-500C for 6-8 hrs.

B. Mass balance

Sr.No. Input kgs Output kgs

1. Chloro acetyl chloride 950 Chloro acetyl Xylidine 1600
2. 2,6- Xylidine 950 Toluene recovered 1850
3. Soda ash 30 Hydrochloric acid 306
4. Toluene 1900 Drying loss 50
5. residue 24
Total 3830 3830

C. Process flow diagram

Flow Diagram of Chloro acetyl xylidine

Reactor
chloro acetyl chloride (950 kgs) toluene recover (1850 kgs)
2,6-xylidine (950 kgs) hydrochloric acid (306 kgs)
soda ash (30 kgs) water (17.9 kgs)
Toluene (1900 kgs) effluent (1203.5 kgs)

centrifuge
residue (24 kgs)

w/c, dryer
drying loss (50 kgs)

Chloro acetyl Xylidine : 1600 KGS

D. Reaction Chemistry
 Methyl Nicotinate

A. Brief process of synthesis

It was prepared by esterification of nicotinic acid by refluxing at 60 to 650C for 6-8 hrs.
With methanol in the presence of concentrated sulphuric acid, esterification product
obtained, after methanol distilled material extracted into organic solvent (chloroform)
after neutralization of the reaction mixture with 10% sodium bicarbonate. Recovered
chloroform and filter it and dry it air drying for10-12 hrs.

B. Mass balance
Stage-1: Methyl nicotinate

Sr.No. Input kgs Output kgs

1. Nicotinic acid 500 Methyl Nicotinate 500
2. Methanol 1250 Methanol recovered 1225
3. Sulphuric acid 10 Chloroform recovered 720
4. Chloroform 750 effluent 510
5. Sodium bicarbonate 500 Drying loss 28
solution
residue 27
Total 3010 3010
 C. Process flow diagram

Flow Diagram of Methyl Nicotinate

Reactor
Methyl nicotinate (500 kgs) Methanol recover (1225 kgs)
methanol (1250 kgs)
sulfuric acid (10 kgs) water (17.9 kgs)
Chloroform (750 kgs) effluent (510 kgs)
sodium bicarbonate solution (500kgs)

centrifuge REACTOR:
ML Chloroform recovered (720 kgs)
Distillation
Residue (27 kgs)

w/c, dryer
drying loss (28 kgs)

Methyl Nicotinate : 500 KGS

D. Reaction Chemistry
 M/s. Chemcure Lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

ADDITIONAL STUDIES

1.1 Risk Assessment

The risk assessment essentially includes hazards identification, consequence analysis, risk assessment/evaluation and risk mitigation. For
chemical industries, risk assessment is used for determining the risk associated with use, handling, transportation and storage of chemicals
and other hazardous substances. Quantitative Risk Assessments (QRAs) are done if dangerous substances are thought to be present at a
location (e.g. industrial sites and transportation routes) in amounts that can endanger the environment.

Risk assessment studies essentially encompass;

 Consequence analysis using relevant models like ALOHA.
 LDAR for applicable solvents
 Mitigation measures including:
 Risk reduction
 Emergency preparedness – on-site as well as off-site

1.2 Risk Assessment Methodology

A typical risk assessment process consists of following tasks:

 Obtaining detailed description of process and plant
 Identification of hazards
 Identification of vulnerable targets
 Select Most Credible Scenario which can be converted into an accident out of several major and minor.
 Select Worst Case Scenario which has the highest potential to cause an accident of maximum damage
 Identification of mitigating measures
 Estimation of consequences - in the plant in form of fire, explosion and toxic effects

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.2
 M/s. Chemcure Lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

 Estimation of frequency of occurrence

 Estimate Effect of Damage
 Decision making

1.3 Hazard Identification and Risk Assessment (HIRA)

The hazard identification and risk assessment is used to identify possible accidents and estimate their frequency and consequences. While
identifying hazards only those areas of plants having potential risk are used further for risk analysis. Hazard is considered as
characteristic of system/plant/process that presents potential of causing harm to people, property and the environment. Hence, all the
components of a system/plant/process are thoroughly examined to assess their potential for initiating or propagating an unplanned
event/sequence of events, which can be termed as an accident.

1.3.1 Hazard Identification Methods

Hazard identification method used for the proposed expansion project is given below.
 Identification of major hazardous units based on Manufacture, Storage and Import of Hazardous Chemicals Rules, 1989 of
Government of India (as amended in 2000);
 Hazard Indices: Identification of hazardous units and segments of plants and storage units based on relative ranking technique.

1.3.2 Identification of Hazardous Chemicals used within Premises

Following chemicals to be stored and utilized within the premises falls under Manufacture, Storage and Import of Hazardous Chemicals
Rules, 1989 (as amended in 2000). List of Hazardous Chemicals is given below.

1. Amongst the below described raw materials and products, some are the hazardous chemicals as per the MSIHC Rules, 2000.
Chemical and physical properties of raw materials are given in Table 1.1.

Table 1.1- Chemical and Physical Properties of Hazardous Chemicals

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.2
 M/s. Chemcure Lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023
Toxicity Level Flammable Limit
Class Chemic Odor
LD50 al Class thres
TLV/ LD50 (As per NFPA Vapor
Sr. No Chemicals Der (As per hold
TWA Oral LC50 LEL UEL FP BP Petrole Rating Pressure
ma 0 0 MSIHC (ppA
mg/ mg/l % % C C um
mg/ Rules) m)
Kg Classific
Kg
ation)
(chloro(2ch
lorophenyl)
1. N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
methylene)
dibenzene
(E)-2-(6-
methoxy
naphtha
2. N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
len-2-yl)
propanal
oxime
1-(4-
Methoxy
3. N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
phenyl )
Piperazine
LD50 Health
= > 2
1,2,4-
4. N.A 1360 N.A N.A N.A N.A 149 N.A N.A N.A Flammabili N.A N.A
Triazole
0 °C ty
mg/k 1

T. R. Associates (Ahmedabad) Risk Assessment Report

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 M/s. Chemcure Lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

g ( Instability
Rat ) 1

1-(6-
Methoxyna
5. phthalen-2- N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
yl)
ethanone
5370 >5 >20 Health 2
1,2- 0.064
mg/k g/kg mg/L 1.60 10.4 -6 84 - Flammabili
6. Dimethoxye 5 ppm A NA NA kPa @ 20
g ( ( Rat /6h ( % 0% °C 86 °C ty 3
thane °C
Rat ) ) Rat ) Instability 0
7600
5170 48.5 Health 2
mg/k
mg/k mg/L 101 hazardo Flammabili 41 mbar
7. 1,4-Dioxane 20 ppm g ( 2% 22% 12 °C NA NA
g ( ( Rat °C su ty 3 @ 20 °C
Rabb
Rat ) )4h Instability 1
it )
1-[2-(2,4-
Difluoro-
phenyl)
8. oxiranyl N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
methyl]-1H-
[1,2,4]triazo
le
1000 > N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Health: 3
12.5% 8.91 0 1050
Flammabili
Sodium g/kg mg/k 0
9. NA ty: 0
Hypochlorit ( Rat g ( mg/l
Instability:
e solution ) Rabb (Rat)
1
it ) 1h

2,3,5-6- 2,200
10. hydroxy N.A mg/k N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
benzoic acid g

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.2
 M/s. Chemcure Lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

2-{[4-(3-
Methoxypro
poxy)-3-
methyl
11. pyridine-2- N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
yl]methylthi
o}-1H-
benzimidaz
ole
7.7
Rat
2,6-dichloro mg/l
390 220 Hazardo
12. diphenyl N.A N.A 96 N.A N.A N.A N.A N.A N.A N.A
mg/k °C us, Toxic
amine h(fis
g
h)
Health:4
1120 Flammabili
2,6- mg/k 93 218 Hazardo ty: 2
13. N.A. N.A. N.A. N.A. N.A. N.A N.A. N.A
Xylidine g °C °C us Instability:
(Rat) 0

2-Bromo
14. N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
Butane

7.7
Rat -
2-amino- mg/l
390 220 Hazardo
15. 4,6-dichloro N.A N.A 96 N.A N.A N.A N.A N.A N.A N.A
mg/k °C us, Toxic
phenol h(fis
g
h)
3402 Health: 2
700 >
mg/k Highly Flammabili
TWA: mg/k 8000 11.2 35° 117.6 0.67 k Pa
16. 2-Butanol g 1.4 % B Flamma ty: 3 NA
20 ppm g (Rat) % C °C @ 20°C
(Rab ble Instability:
(Rat) 4h
bit) 0

T. R. Associates (Ahmedabad) Risk Assessment Report

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 M/s. Chemcure Lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

2-Cyano-4-
17. methyl N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
biphenyl

2-
chlorometh
yl-4-(3-
methoxy
18. propoxy)-3- N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
methylpyrid
ine
hydrochlori
de
2-
hydroxymet
hyl-4-(3-
methoxy
19. propoxy)-3- N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
methyl
pyridine
hydrochlori
de
2-
mercapto-
1H-benzo
20. N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
[d]
imidazol-6-
ylium
>
1600 2000 Toxic, Health: 3
mg/k 0 > Flamma Flammabili
2-Nitro 168 284
21. N.A g mg/k 2.53 NA NA NA ble,Haza ty: 1 NA 3.68 kpa
Aniline °C °C
( Rat g mg/L rdous Reactivity: at 25 °C
) ( Rat 2
)

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 M/s. Chemcure Lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

3- (Amino
methyl)-5-
22. methyl N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
hexanoic
acid
690
4 Chloro 2
mg/k 170
23. Amino NA NA NA NA NA NA NA NA NA NA NA
g(Rat °C
Phenol
)
LD50
LD50
=
= Health 2
5660 11.5
3-methoxy TWA: 5710 1.70 30 120 Flammabili 1.45321
24. mg/k NA 0 vol B NA NA
propanol 50 ppm mg/k vol % °C °C ty 3 4 kpa
g ( %
g ( Instability 0
Rabb
Rat )
it )
4-
(chloromet Health 2
hyl)-5- 129 Flammabili
25. N.A N.A N.A N.A N.A N.A 90 °C N.A N.A N.A N.A
methyl-1,3- °C ty 1
dioxol-2- Instability 0
one

4-
26. Chlorobutyr N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
yl chloride

50 Health 4
4-Chloro 265 -
5 mg/k 133 Flammabili
27. benzyl NA NA N.A N.A 267 NA N.A N.A N.A
mg/m3 g ( °C ty 1
cyanide °C
Rat Instability 0
4'-Methyl-
2-
28. NA NA NA NA NA NA NA NA NA NA NA NA NA
cyanobiphe
nyl

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 M/s. Chemcure Lifesciences LLP
Plot No.514/515/516, Bamanbore GIDC,
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Rajkot, Gujarat-360023

4-Chloro-
2,3-
Health 2
dimethyl
Flammabili
29. pyridine-N- NA NA NA NA NA NA NA NA NA NA NA NA
ty 1
oxide
Instability 0
hydrochlori
de
4-
propylthio-
30. o- NA NA NA NA NA NA NA NA NA NA NA NA NA
phenylene
diamine
5-amino-2-
(propylthio)
31. NA NA NA NA NA NA NA NA NA NA NA NA NA
pyrimidine-
4,6-diol
Health
5-
2
diFluorome
Flammabili
thoxy-2-
32. NA NA NA NA NA NA NA NA NA NA ty NA NA
mercapto-
1
benzimidaz
Instability
ole
0
Health 2
5-chloro
Flammabili
33. salicylic NA NA NA NA NA NA NA NA NA NA NA NA
ty 0
acid
Instability 0

Hazardo Health: 3
TWA: 3310 1060 us Flammabili
5620 43° 118° 0.48 2.09 kPa
34. Acetic acid 10 15 mg/k mg/k 4 19.9 B ,Highly ty: 2
ppm C C ppm at 25°C
(ppm) g g Flamma Reactivity:
ble 0

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Hazardo Health: 3
630 4320 0.12
4200 us Flammabili
Acetic TWA: 5 mg/k mg/k 10.3 52 137 to 0.51 kPa
35. mg/ 2.7% B ,Highly ty: 2
Anhydride ppm g g % °C °C 0.36 at 20°C
m3 Flamma Reactivity:
(Rat) (Rat) ppm
ble 0

1580
Health – 2
5800 0 76 Hazardous
TWA: Flammabili 62- 30.93
mg/k mg/k mg/l, 12.8 -20 ,Toxic
36. Acetone 250 2.5% 56 °C A ty –3 140 kPa at
g g 4 h, % °C Highly
ppm Instability - ppm 25°C
(Rat ) (rabb (rat) Flammable
0
it)
2.000 Hazardo Health: 2
2460
mg/k us,Toxic, Flammabili
mg/k 27.3 81- 9.7 kPa
37. Acetonitrile NA g 3% 16% 6 °C A Highly ty: 3 N.A
g mg/L 82 °C @ 20°C
(Rab Flamma Instability:
(Rat ) (Rat)
bit ) ble 0
> Health: 1
TWA 8000 Flammabili 0.133
Activated
38. 10mg/ mg/k N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A ty: 2 NA kpa @
Carbon
m3 g Reactivity: 3586°C
(Rat) 0
200 Health: 4
3470 Hazardo
mg/k Flammabili
Aluminium mg/k us,
39. N.A g N.A N.A. N.A. N.A. N.A N.A. ty: 0 N.A N.A
chloride g ( Highly
(Rab Instability:
Rat ) toxic
bit ) 2

Ammonium 0.0001
40. N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
acetate kpa

Ammonium 10 34.7
41. N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
Carbonate mg/m3 mg/l

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Rajkot, Gujarat-360023

Ammonium
salt of
42. N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
cyano
Carbamate
Health: 2
750 1100 Flammabili
Ammonium 190 Hazardo
43. N.A mg/k mg/k N.A N.A N.A N.A N.A ty: 1 N.A N.A
thiocyanate °C us
g g Reactivity:
0

Hazardo
44. Ammonia N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A
us

Oral
HEALTH: 2
Rat
Azo bis FLAMMABI
100
45. isobutyroni N.A N.A N.A N.A N.A N.A N.A N.A NA LITY: 3 N.A N.A
mg/k
trile REACTIVIT
g
Y: 3
LD50
Hazardo
Health: 2
us,
TWA: 930 - Flammabili 9.99 kPa
80.1° Extreme
46. Benzene 0.5 mg/k N.A. N.A. 1.3% 7.1% 11° A ty: 3 N.A. at @ 20
C ly
ppm g C Instability: °C
flammab
0
le
>
1900 Health: 3
2000 1.45
Ceiling: mg/k Highly Flammabili
Benzoyl mg/k mg/L 93 198 0.05 kPa
47. 0.5 g 1.2% 4.9% C Toxic,ha ty: 2 0.047
Chloride g ( Rat) °C °C @ 20 °C
ppm ( Rat zardous Reactivity:
(Rab 4h
) 2
bit )
3100 750 Health: 3
mg/k ppm/ Flammabili 23.33
TWA: Hazardo
48. Bromine g N.A. 9M N.A. N.A. N.A. 59°C N.A. ty: 0 N.A. kPa @ 20
0.66 us
(Mou (Mou Reactivity: 0C
se). se). 0

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250 Health 3
Bromo-
mg/k 155 Flammabili
49. Dimethyl NA NA NA NA NA NA NA NA NA NA
g ( °C ty 1
hydantoin
Rat ) Instability 0
3402 Health: 2
700 >
mg/k Highly Flammabili
TWA: mg/k 8000 11.2 35° 117.6 0.67 k Pa
50. Butanal g 1.4 % B Flamma ty: 3 NA
20 ppm g (Rat) % C °C @ 20°C
(Rab ble Instability:
(Rat) 4h
bit) 0
1350 Health: 3,
Ceiling: mg/k Flammabili 0.133
Caustic 1390 Hazardo
51. 2 N.A. g N.A. N.A. N.A. N.A. N.A. ty: 0, NA kpa
soda lye °C us
mg/m3 (Rab Reactivity: @739 °C
bit) 1
Health: 4
146 Hazardo
- Flammabili
0.5 ppm/ us ,Toxic 3.4 678.0
52. Chlorine gas NA NA N.A N.A N.A. 34.05 N.A ty: 0
ppm 4h Hazardo ppm kPa 20°C
°C Instability:
(Rat) us
0
208
Chloro
mg/k 105 Hazardo 6.2 kPa
53. acetyl N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
g °C us @ 20 0C
chloride
(Rat)
>
2000 Health: 2
TWA: 695 117 -
0 Flammabili 133 - 20.95
10 ppm mg/k 125 Hazardo
54. Chloroform mg/k N.A. N.A. N.A. 61 °C N.A. ty: 0 276 kPa @20
8 g mg/l us
g Reactivity: ppm 0C
hour(s) (Rat) (Rat)
(Rab 0
bit)

306 104
Chlorphenir
55. N.A. mg/k mg/k N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
amine base
g g

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N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Cis-Bromo
56.
Benzoate

Health: 1
CitricAcid 6730 Flammabili
57. Monohydrat N.A mg/k N.A N.A N.A N.A N.A N.A N.A N.A ty: 0 N.A N.A
e g Reactivity:
0
Health: 2
2,000
>500 - Flammabili
Cyclohexan mg/k 13.9 Hazardo 10.4Kpa
58. N.A 0 N.A N.A 17.9 81°C A ty :3 N.A
e g mg/l us @ 20°C
mg/l °C Instability:
(rat)
0
250 Health 3
Di bromo di
mg/k 155 Flammabili
59. methyl NA NA NA NA NA NA NA NA NA NA
g ( °C ty 1
hydantoin
Rat ) Instability 0
Toxic Health:2
Flamma Flammabili
Dimethyl 58
60. NA NA NA NA NA NA NA B ble ty: 2 NA NA
formamide °C
Hazardo Instability:
us 1
> 2 >
Health 1
> 10 g/kg 0.259
Dicyano Flammabili
61. NA g/kg ( mg/L NA NA NA NA NA NA NA NA
diamide ty 1
( Rat Rabb /4h (
Instability 0
it ) Rat )
11.9
= 780 Health 2
1 mL/k 9.8
Diethanol mg/k 1.6 138 268 Hazardo Flammabili 0.0013
62. mg/m3 g ( NA vol NA NA
amine g ( vol % °C °C us ty 1 kpa
Skin Rabb %
Rat ) Instability 1
it )

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diethyl 2-
propyl-1H-
imidazole -
63. NA NA NA NA NA NA NA NA NA NA NA NA NA
4,5-
dicarboxyla
te
290
500 Health 3
Diethyl mg/k
mg/k Flammabili
64. amino NA g ( NA NA NA NA NA NA NA NA NA
g ty 1
ethanol Rabb
(Rat) Instability 1
it )
LD50 68 °C N.A.
LD50
> -29 / Health: 2
=
TWA: 2000 21 °C / 154.4 Flammabili
Diisopropyl 4700 1.1 18 kpa @
65. 250 mg/k N.A vol - °F @ A ty: 3 N.A
ether mg/k vol % 20 °C
ppm g ( % 20.2 760 Instability:
g (
Rabb °F mmH 1
Rat )
it ) g
Health:2
1070
Flammabili
Dimethyl mg/k hazardo
66. N.A N.A N.A N.A N.A N.A N.A N.A ty: 1 N.A N.A
amine HCl g us
Instability:
(Rat )
0

Dimethyl
67. amino ethyl
chloride

1220
1803 1641 Health 3
Dimethyl mg/k 11.9
mg/k ppm 1.60 40 139 Flammabili
68. amino NA g ( 0 vol B NA NA 0.61kpa
g ( ( Rat vol % °C °C ty 2
ethanol Rabb %
Rat ) )4h Instability 1
it )
2900 >720
Dimethyl
mg/k mg/
69. amino NA NA NA NA NA NA NA NA NA NA NA
g m3
propanol
(Rat) (Rat)

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45 Health: 4
106 Toxic,
TWA: mg/ Flammabili 0.103 k
Dimethyl mg/k 23.2 83° 188° Flamma
70. 0.1 NA m3 3.6 % C ty: 2 Pa @
sulphate g % C C ble
ppm (Rat) Instability: 20°C
(Rat)
4h 1
N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. Health N.A. N.A.
LD50 2
> 2 Flammabili
Disodium
71. N.A. g/kg ty
EDTA
( Rat 1
) Instability
0
N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Dipropyl
72. malonic
acid

2800 Health: 3
625 7.8
TWA: mg/k Flammabili 10.245
Ethylene mg/k mg/l 15.9 13 -35 Highly 26
73. 10 ppm g ( 6.2% A ty: 3 kpa @ 25
dichloride g ( ( Rat % °C °C Flamma ppm
STEL:2 Rabb Instability: °C
Rat ) ) 4h ble
ppm it ) 0
>
ACGIH 1074 1600 Health: 2
Very
STEL 0 0 Flammabili
25 Highly 100 5.9 kPa
74. Ethanol (ppm) mg/k mg/k N.A. N.A. N.A. 78 °C B ty: 3
°C Flamma ppm (20 °C)
1000 g g Reactivity:
ble
ppm (Rat) (Rab 0
bit)
Very
Highly
1020 > 20 Health: 3
58 Flamma
TWA: 0 mL/k Flammabili
Ethyl mg/l 2.0% 11.5 -4 ble, 10.3 kPa
75. 400 mg/k g 78 °C A ty: 2 3.9
acetate (rat; % °C Extreme @ 20°C
ppm g (Rab Reactivity:
8 h) ly
(Rat) bit) 0
toxic,haz
ardous

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N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Formamidi
76.
ne

Health: 1
7930 Flammabili
77. Glycine N.A mg/k N.A N.A N.A N.A N.A N.A N.A N.A ty: 1 N.A N.A
g Reactivity:
1
ATE
ATE Health: 4
= 200 ATE
= 50 - Flammabili
Hydrazine - = 0.5 100 91 117.2 1.3 kpa
78. N.A 300 4.7% C ty: 2 N.A
Hydrate 1000 - 2 % °C °C @ 20 °C
mg/k Instability:
mg/k mg/l.
g. 1
g

>
277 Health: 3
5010 1.68 Hazardo
mg/k Flammabili 0.25-
Hydrochlori Ceiling: mg/k mg/L us, 12.5 kPa
79. g N.A. N.A. N.A. 57 °C N.A. ty: 0 10
c Acid 2 ppm g (Rat) Highly @ 20 °C
(Rat) Reactivity: ppm
(Rab 1h Toxic
1
bit )

Health: 3
Flammabili
Hydrogen hazardo
80. NA NA NA NA NA NA NA -67°C NA ty: 0 NA NA
Bromide us
Reactivity:
3
Health: 3
>90 4060 2000 Non
Hydrogen Flammabili
TWA : mL/k mg/k mg/ com 108 Hazardo 0.05 3 KPa @
81. peroxide 100 N.A ty: 0
1 ppm g g m3 40% bust °C us ppm 30C
(30%) % Reactivity:
(Rat) (Rat) (Rat) ible
1
hydroxylam LD50 Health 3
ine = 141 Flammabili
82. NA NA NA NA NA NA NA NA NA NA NA
hydrochlori mg/k ty 3
de g ( Instability 1

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Rajkot, Gujarat-360023

Rat )

Hydrzobenz
83. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
ene

Health: 1
Flammabili 1.33 kPa
2230
84. Hyflo N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A ty: 0 NA @ 1732
°C
Reactivity: °C
0

85. Indolenone N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A

1390
5840 Health: 1
0 72.6
TWA: mg/k Hazardo Flammabili 40-
Isopropyl mg/k mg/L 12.7 18 4.4 kPa
86. 200 g 2.0% 82 °C A us,Flam ty: 3 200p
alcohol g (Rat) % °C @ 20 °C
ppm (Rat) mable Reactivity: pm
(Rat) 4h
0
1390 Health:2
5840 72.6
TWA: 0 Flamma Flammabili 4.39964
mg/k mg/L 12.0 15 82.8
87. IPA HCl 200 mg/k 2.0% A ble ty: 3 N.A kpa @
g ( ( Rat % °C °C
ppm g ( Instability: 20°C
Rat ) )4h
Rat ) 1
Health: 2
210
L-Tartaric Flammabili
°C /
88. acid diethyl N.A N.A N.A N.A N.A N.A N.A A N.A. ty: 1 N.A N.A
410
ester Instability:
°F
0

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NA NA NA NA NA NA NA NA NA NA NA NA
89. L-Valine NA

>
Health: 2
190
Flammabili
Mandelic °C /
90. N.A N.A N.A N.A N.A N.A N.A A N.A. ty: 2 N.A N.A
acid >
Instability:
374
0
°F
LD50 Health
LC50
LD50 = 3
> 720
= 708 1560 Flammabili
mg/ 127 0.030
91. Maleic acid N.A mg/k mg/k N.A N.A N.A N.A N.A ty NA
m3 ( °C KPa
g ( g ( 1
Rat )
Rat ) Rabb Instability
1h
it ) 0
2000 >
- 7940 13.5 Health 2
Mono 9.6
TWA: 4000 mg/k mg/L 1.8 23 131 Flammabili
92. Chloro vol B NA NA NA
10 ppm mg/k g ( ( Rat vol % °C °C ty 3
benzene %
g ( Rabb )7h Instability 0
Rat ) it )
Health 2
1410 5000 > 289 -
Flammabili
93. Maltol NA mg/k mg/k NA NA NA 100 290 NA NA NA NA
ty 1
g Ora g °C °C
Instability 0
LD50 LC50 Health: 4
250
Methane = 200 = 25 Flammabili
mg/k 110 161 0.26 kpa
94. Sulfonyl N.A mg/k ppm N.A N.A C ty: 0 N.A
g ( °C °C @ 20 °C
Chloride g ( ( Rat Instability:
Rat )
Rat ) )4h 0
1187 1710 Hazardo Health: 2
128.2
- 0 us, Very Flammabili
mg/l, 9.7 64.7 12.8 kPa
95. Methanol N.A. 2769 mg/k N.A. N.A. A Highly ty: 3 --
4h °C °C (20 °C)
mg/k g Flamma Reactivity:
(Rat)
g (Rab ble 0

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(Rat) bit)

>
1650 2000 180 Health 3
Methyl 12.0
TWA: mg/k mg/k mg/L 1.50 -17 Flammabili
96. magnesium 0 vol 66 °C A NA NA NA
50 ppm g ( g ( Rat vol % °C ty 3
chloride %
Rat ) (Rab )1h Instability 2
bit)
Rabb
Rat it
oral derm
Methyl Tert LD50 al 15%
TLV: 50 2%[v -33 27.9 kPa
97. Butyl Ether = LD50 N.A [vol 55°C A N.A N.A N.A
ppm ol% °C @20 °C)
(MTBE) 3866 = %
mg/k >10.0
g gm/k
g.
> >
53 Health 2
2000 2000 23
Methylened TWA: mg/L 13 39 -97 Flammabili 35 kpa@
98. mg/k mg/k vol B NA
ichloride 50 ppm ( Rat vol % °C °C ty 1 20°C
g ( g ( %
)6h Instability 0
Rat ) Rat )
>
1650 2000 180 Health 3
Methylmag
TWA: mg/k mg/k mg/L Flammabili
99. nesium NA NA NA NA NA NA NA NA
50 ppm g ( g ( Rat ty 3
bromide
Rat ) (Rab )1h Instability 2
bit)
NA NA NA NA NA NA NA NA NA NA NA NA
N-Bromo
100. succinamid NA
e

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Plot No.514/515/516, Bamanbore GIDC,
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3402 Health: 2
700 >
mg/k Highly Flammabili
n-Buthyl TWA: mg/k 8000 11.2 35° 117.6 0.67 k Pa
101. g 1.4 % B Flamma ty: 3 --
Alcohol 20 ppm g (Rat) % C °C @ 20°C
(Rab ble Instability:
(Rat) 4h
bit) 0

N-Butyl
109 150
102. diethyl NA NA NA NA NA NA NA NA NA NA NA
°C °C /
malonate

N-Chloro
acetyl 2,6- 487.5
103. dichloro NA NA NA NA NA NA NA ±45.0 NA NA NA NA NA
diphenyl °C
amine
Hazardo
3000 4800 us, Very Health: 2
2500
mg/k 0 Highly Flammabili
mg/k 7.5 -22 16 kPa
104. n-Hexane N.A. g ppm 1.1 % 69 °C A Flamma ty: 3 --
g % °C @ 20 °C
(Rab (Rat) ble Reactivity:
(Rat)
bit ) 4h Hazardo 0
us
LD50
LD50
> Health 2
= 7
Nicotinic 2000 Flammabili
105. NA g/kg NA NA NA NA NA NA NA NA NA
acid mg/k ty 0
( Rat
g ( Instability 0
)
Rat )

>
272
106. OTBN NA NA NA NA NA NA 110 NA NA NA NA NA
°C
°C

Health: 2
Ortho- 1600 Flammabili
152
107. Chlorobenz N.A. mg/k N.A. N.A. N.A. N.A. N.A. N.A. N.A. ty: 2 N.A. N.A.
°C
otrichloride g; Reactivity:
1

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Rajkot, Gujarat-360023

LD50
Health 4
Otho Chloro = 400
191 Flammabili
108. Para Nitro mg/k N.A. N.A. N.A. N.A. NA NA NA NA NA
°C ty 1
Aniline g (
Instability 0
Rat )

Para toluic
109. NA NA NA NA NA NA NA NA NA NA NA NA NA
acid

LD50 LC50
LD50
= 64 <= Health 4
= 342 168 -
P-chloro mg/k 6.05 64 Flammabili
110. NA mg/k NA NA 170 NA NA NA NA
pyridine g ( mg/L °C ty 2
g ( °C
Rabb ( Rat Instability 0
Rat )
it ) )6h
188 -
LD50 189
LD50
= °C / Health: 4
= 0.18 80
Phenyl 3970 370.4 Flammabili 0.2 kpa
1410 mg/L °C /
111. Chloro N.A μL/k N.A N.A - C N.A ty: 1 @ 37.5
μL/k /4h 176
formate g ( 372.2 Instability: °C
g ( (rat) °F
Rabb °F @ 2
Rat )
it ) 1013
mbar
LD50 LC50
LD50 Health: 4
> 250 = 308 107
Phosphorou = 380 Flammabili
0.1 mg/k mg/ °C / hazardo 3.6 kpa
112. s mg/k N.A N.A N.A N.A ty: 0 N.A
ppm g ( m3 ( 224.6 us @ 20 °C
oxychloride g ( Instability:
Rabb Rat ) °F
Rat ) 2
it ) 4h
LD50
= Health 3
>
Phosphorus 1895 200 hazardo Flammabili
113. N.A N.A N.A N.A N.A 100 C N.A N.A
Acid mg/k °C us ty 1
°C
g ( Instability 1
Rat )

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Rajkot, Gujarat-360023

TWA:
104
0.2 Health: 4
18 ppm Very
STEL: Flammabili
Phosphorou mg/k 4 Hazard 13.3 kPa
114. 0.5 NA NA NA NA 76°C NA ty: 0 NA
s trichloride g hour highly (@ 20°C
(ppm) Reactivity:
[Rat] s toxic
from 2
[Rat]
ACGIH
NA NA NA NA NA NA NA NA NA NA NA NA
Potassium
115. butan-2- NA
olate

> Health: 2
2000 Flammabili
Potassium
116. N.A. mg/k N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A ty: 0 N.A. N.A.
carbonate
g Reactivity:
(Rat) 1
LD50
Health: 3
Ceiling: = 284
Flammabili
Potassium 2 mg/k 1320 Hazardo 0.01 kPa
117. N.A. N.A. N.A. N.A. N.A. N.A. ty: 0 --
hydroxide mg/m3 g °C us @ 20 °C
Reactivity:
( Rat
1
)
NA NA NA NA NA NA NA NA NA NA NA NA
Potassium
118. phthalamid NA
e

NA NA NA NA NA NA NA NA NA NA NA NA

119. SABMA NA

20 0.054 hazardo Health: 4

27
Ceiling: mg/k -0.52 su Flammabili
Sodium mg/k 300
120. 0.29 g mg/L N.A N.A N.A N.A ty: 1 N.A N.A
Azide g ( °C
mg/m3 (Rab (dust Instability:
Rat )
bit) ) 2

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3360
mg/k
Sodium
121. NA g NA NA NA NA NA NA NA NA NA NA NA
bicarbonate
(Mou
se)
Health: 3
1310
Flammabili
Sodium TWA-5 mg/k
122. N.A N.A N.A N.A N.A N.A N.A HAZARD ty: 0 N.A N.A
bisulphite mg/m3 g (
Reactivity:
Rat )
2
>200
Health: 3
57 0
Sodium Flammabili
N.A. mg/k mg/k NA 3.02 Hazardo
123. borohydrid NA N.A. NA N.A. ty: 3 NA NA
g ( g ( % us
e Instability:
Rat ) Rabb
2
it )
2300
Health: 2
mg/
4090 Flammabili
Sodium m3 Hazardo
124. N.A. mg/k N.A. N.A. N.A. N.A. N.A. N.A. ty: 0 N.A. N.A.
Carbonate (2 us
g Reactivity:
Hrs)
1
(Rat)
> 10 Health: 1
3 > 42
g/kg Flammabili 0.133
Sodium g/kg g/m3
125. NA ( NA NA NA 1461 NA NA ty: 0 NA kpa@
Chloride ( Rat ( Rat
Rabb °C Reactivity: 865 °C
) )1h
it ) 1
0.5 to 200 Toxic Health:3
234
Sodium 20 ppm 5 mg/k Flamma Flammabili 2.266
444 to 4.7
126. Hydro (Ceiling gm/k m 46% 4.3% NA NA ble ty: 2 kpa @
ppm 243° ppb
Sulphide ) g (Mou Hazardo Instability: 68°F
F
(Rat) se) us 1
LD50
= >5.5 Health 3
Sodium >2
2500 mg/L Flammabili
127. Hydro NA g/kg NA NA NA NA NA NA NA NA
mg/k /4h ( ty 3
Sulphite ( Rat)
g ( Rat ) Instability 2
Rat )

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1350 Health: 3,
Ceiling: mg/k Flammabili
Sodium 1390 Hazardo 0.13 kPa
128. 2 N.A. g N.A. N.A. N.A. N.A. N.A. ty:0, N.A
hydroxide °C us @ 739 °C
mg/m3 (Rab Reactivity:
bit) 1
1000 >
Health: 3
8.91 0 1050
Sodium Flammabili
N.A. g/kg mg/k 0
129. Hypochlori N.A. N.A. N.A. N.A. N.A. N.A. ty: 0 N.A. N.A.
( Rat g ( mg/l
de Instability:
) Rabb (Rat)
1
it ) 1h
LD50
LD50 Health: 3
=
Sodium > 2 Flammabili
TWA: 5 1310 Hazardo
130. meta g/kg N.A N.A N.A N.A N.A A ty: 0 N.A N.A
mg/m3 mg/k us
bisulphate ( Rat Instability:
g (
) 1
Rat )
LD50
LD50 Health: 3
=
Sodium > 2 Flammabili
TWA: 5 1310 Hazardo
131. metabisulp g/kg N.A N.A N.A N.A N.A A ty: 0 N.A N.A
mg/m3 mg/k us
hite ( Rat Instability:
g (
) 1
Rat )
Health: 3
TWA: 50 - 200 -
44 Toxic Flammabili 0.15
Sodium 200 300 1000 2 - 10 5.50 33
132. vol 93 °C B Hazardo ty: 3 NA kpa@ 50
Methoxide ppm mg/k mg/k mg/ vol % °C
% us Reactivity: °C
g g.
1
N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. Health
LD50
1
>
Flammabili
Sodium N.A. 5000 N.A. N.A.
133. ty
thiosulfate mg/k
0
g (
Instability
Rat )
0

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29
mg/l
Health: 3
2140 (24
Flammabili < 0.04
N.A. mg/k N.A. h, 288 Hazardo
134. Sulfuric acid N.A. N.A. N.A. N.A. ty: 0 0.15 kPa @ 25
g Daph °C us
Reactivity: °C
(Rat) nia
2
magn
a)
Health- 2
Tetra butyl Flammabili
135. Ammonium N.A N.A N.A N.A N.A N.A N.A N.A N.A N.A ty-1 N.A N.A
Bromide Reactivity-
0
> Health: 2
1.650 147
2.000 650- Highly Flammabili 20 KPa
Tetrahydrof mg/k mg/L 118 -170
136. 50 ppm mg/k 2% 670 A flammab ty: 3 NA @ 20 deg
uran g ( Rat) % °C
g °C le Instability: C
(Rat ) 6h
(Rat ) 1
Health 2
Thiamine
Flammabili
137. hydrochlori NA NA NA NA NA NA NA NA NA NA NA NA
ty 1
de
Instability 1
Thiamine
monophosp
138. NA NA NA NA NA NA NA NA NA NA NA NA NA
hate
chloride

Health: 4
500
Flammabili
Thionyl 1 ppm ppm Flamma 12.9 kPa
139. N.A. N.A. N.A. N.A. N.A. 76 °C N.A. ty: 0 N.A.
chloride Ceiling 1h ble @ 20 °C
Reactivity:
(Rat)
2
Health- 3
>500 1200 Very
2670 Flammabili
TWA: 0 0 Highly 2.9 kPa
140. Toluene 0 1.1 7.1 4 111 A ty-3 2.14
20 ppm mg/k mg/k Flamma @ 20 °C
ppm Reactivity-
g g ble
0

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LD50
LD50
= 195 0.5 Health 4
= 420
Tributyl mg/k mg/l 75 215 hazardo Flammabili 0.03 kpa
141. NA mg/k 1.4% 6% C NA
Amine g /4 h °C °C / us ty 2 @ 20 °C
g
(Rab (Rat) Instability 1
(Rat)
bit)
415 Toxic, Health- 3
460 1250
mg/k Very Flammabili
Triethyl TWA: 1 mg/k ppm 11 0.005 6.9 kPa
142. g 1.2% 8.0% 90 °C A Highly ty-3
amine ppm g (Rat) °C -2.9 @ 20 °C
(Rab Flamma Reactivity-
(Rat) 4h
bit) ble 0
Health:1
Flammabili
Trityl ty: 0
143. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
chloride Instability:
0

Health: 0
8471
Flammabili 0.166
mg/k Hazardo
144. Urea N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. ty: 1 kpa @ 25
g us
Reactivity: °C
(Rat)
0
332 -
Health 3
705 139 -
Valeronitril TWA: 5 40 Flammabili
145. mg/k N.A. N.A. N.A. N.A. 141 B N.A N.A. N.A.
e mg/m3 °C ty 2
g °C
Instability 0
(Rat)
1410
Health: 3
3608 0 4330 Very
TWA: 143 - Flammabili
mg/k mg/k ppm 6.7 31 Highly 0.88 kPa
146. Xylene 100 0.9 % 145 B ty: 3 NA
g g (Rat) % °C Flamma @ 25 °C
ppm °C Reactivity:
(Rat) (Rab 6h ble
0
bit)
350 Health 3
Zinc TWA: 1 mg/k 732 Flammabili
147. NA NA NA NA NA NA NA NA NA
chloride mg/m3 g °C ty 0
(Rat) Instability 1

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(chloro(2ch
lorophenyl)
148. NA NA NA NA NA NA NA NA NA NA NA NA NA
methylene)
dibenzene
(E)-2-(6-
methoxy
naphtha
149. NA NA NA NA NA NA NA NA NA NA NA NA NA
len-2-yl)
propanal
oxime

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Note: * indicates chemicals are falls under Hazardous chemicals as per MSIHC rule, 2000. Remaining chemicals are taken in to
consideration as per their higher NFPA rating.
The Toxicity level of hazardous chemicals as per Manufacture, Storage and Import of Hazardous Chemical (Amendment) Rules, 2000
(MSIHC) is shown as below:

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Table 1.1 - Toxicity of Chemicals capable of producing MAHs [1]

Oral Toxicity Dermal Toxicity Inhalation Toxicity

Sr. No. Toxicity
LD50 (mg/kg) LD50 (mg/kg) LC50 (mg/l)
1. Extremely Toxic >5 <40 <0.5
2. Highly Toxic >5- 50 >40-200 <0.5-2.0
3. Toxic >50-200 >200-1000 >2-10
1.3.3 Storage Details of Raw Material and Products
Details of the raw materials and products with storage are given in Table 1.3 (A) and (B) respectively.

Table 1.2 (A) - Storage Details of Raw Materials

Sr. No. Name of Raw Requirement (MT)
Physical Mode of Storage No. of Total Inventory
Material Per Per Day Storage Capacity(MT) Units Storage
Form Day
Month
1. (chloro(2chlorophenyl)
26.7 1.068 Liquid HDPE Drum 0.2 38 7.6 7
methylene)dibenzene
2. (E)-2-(6-methoxy
naphtha len-2-yl) 21.5 0.86 solid bag 0.05 121 6.05 7
propanal oxime
3. 1-(4-Methoxy phenyl )
5.8 0.232 solid bag 0.05 33 1.65 7
Piperazine
4. 1,2,4-Triazole 3.616 0.14464 solid bag 0.05 21 1.05 7
5. 1-(6-
Methoxynaphthalen-2- 20.64 0.8256 solid bag 0.05 116 5.8 7
yl) ethanone
6. 1,2-Dimethoxyethane 40 1.6 Liquid drum 0.2 24 4.8 3
7. 1,4-Dioxane 42 1.68 Liquid drum 0.2 26 5.2 3
8. 1-[2-(2,4-Difluoro- 6.2 0.248 solid bag 0.05 35 1.75 7

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phenyl) oxiranyl
methyl]-1H-
[1,2,4]triazole
9. 12.5% Sodium
22.4 0.896 Liquid drum 0.2 32 6.4 7
Hypochlorite solution
10. 2,3,5-6-hydroxy
12.28 0.4912 solid bag 0.05 30 1.5 3
benzoic acid
11. 2-{[4-(3-
Methoxypropoxy)-3-
methyl pyridine-2- 11.768 0.47072 solid bag 0.05 29 1.45 3
yl]methylthio}-1H-
benzimidazole
12. 2,6-dichloro diphenyl
14.95 0.598 solid bag 0.05 84 4.2 7
amine
13. 2,6- Xylidine* 23.75 0.95 liquid drum 0.2 19 3.8 4
14. 2-Bromo Butane 2.36 0.0944 solid bag 0.05 8 0.4 4
15. 2-amino-4,6-dichloro
9.064 0.36256 solid bag 0.05 30 1.5 4
phenol
16. 2-Butanol 11.61 0.4644 Liquid drum 0.2 17 3.4 7
17. 2-Cyano-4-methyl
8.544 0.34176 solid bag 0.05 48 2.4 7
biphenyl
18. 2-chloromethyl-4-(3-
methoxy propoxy)-3-
35.75 1.43 solid bag 0.05 201 10.05 7
methylpyridine
hydrochloride
19. 2-hydroxymethyl-4-(3-
methoxy propoxy)-3-
34.32 1.3728 solid bag 0.05 193 9.65 7
methyl pyridine
hydrochloride
20. 2-mercapto-1H-benzo
22.022 0.88088 solid bag 0.05 124 6.2 7
[d] imidazol-6-ylium
21. 2-Nitro Aniline 28.8 1.152 solid bag 0.05 162 8.1 7
22. 3- (Amino methyl)-5-
8.4252 0.337008 solid bag 0.05 48 2.4 7
methyl hexanoic acid

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23. 4 Chloro 2 Amino

20 0.8 solid bag 0.05 112 5.6 7
Phenol
24. 3-methoxy propanol 21.71 0.8684 Liquid drum 0.2 31 6.2 7
25. 4-(chloromethyl)-5-
methyl-1,3-dioxol-2- 5.296 0.21184 Liquid drum 0.2 8 1.6 7
one
26. 4-Chlorobutyryl
7.36 0.2944 Liquid drum 0.2 11 2.2 7
chloride
27. 4-Chloro benzyl
8.55 0.342 solid bag 0.05 48 2.4 7
cyanide
28. 4'-Methyl-2-
31.9648 1.278592 solid bag 0.05 180 9 7
cyanobiphenyl
29. 4-Chloro-2,3-dimethyl
pyridine-N-oxide 40.08 1.6032 solid bag 0.05 225 11.25 7
hydrochloride
30. 4-propylthio-o-
18.705 0.7482 solid bag 0.05 105 5.25 7
phenylene diamine
31. 5-amino-2-(propylthio)
40 1.6 solid bag 0.05 224 11.2 7
pyrimidine-4,6-diol
32. 5-diFluoromethoxy-2-
mercapto- 33.6 1.344 solid bag 0.05 189 9.45 7
benzimidazole
33. 5-chloro salicylic acid 12.5 0.5 solid bag 0.05 70 3.5 7
34. Acetic acid 111.12 4.4448 Liquid drum 0.2 156 31.2 7
35. Acetic Anhydride 27.84 1.1136 Liquid drum 0.2 39 7.8 7
36. Acetone 776 31.04 Liquid drum 0.2 1087 217.4 7
37. Acetonitrile 40.112 1.60448 Liquid drum 0.2 57 11.4 7
38. Activated Carbon 6.27 0.2508 solid bag 0.05 36 1.8 7
39. Aluminium chloride 146.38 5.8552 solid bag 0.05 820 41 7
40. Ammonium acetate 23.92 0.9568 solid bag 0.05 134 6.7 7
41. Ammonium Carbonate 60.04 2.4016 solid bag 0.05 337 16.85 7
42. Ammonium salt of
9.802 0.39208 solid bag 0.05 55 2.75 7
cyano Carbamate

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43. Ammonium
32.56 1.3024 Liquid drum 0.2 46 9.2 7
thiocyanate
44. Ammonia 14.786 0.59144 Liquid drum 0.2 21 4.2 7
45. Azo bis isobutyronitrile 0.32 0.0128 solid bag 0.05 2 0.1 7
46. Benzene 312.225 12.489 Liquid drum 0.2 438 87.6 7
47. Benzoyl Chloride 1.242 0.04968 Liquid drum 0.02 18 0.36 7
48. Bromine 26.44432 1.057773 Liquid bottle 0.003 1411 4.233 4
49. Bromo-Dimethyl
23.84 0.9536 Liquid drum 0.2 34 6.8 7
hydantoin
50. Butanal 4.192 0.16768 Liquid drum 0.2 6 1.2 7
51. Caustic soda lye 80.9 3.236 Liquid drum 0.2 114 22.8 7
52. Chlorine gas 14.8 0.592 gas tonner 0.9 2 1.8 2
53. Chloro acetyl chloride 34.1 1.364 Liquid drum 0.2 48 9.6 7
54. Chloroform 73.8 2.952 Liquid drum 0.2 104 20.8 7
55. Chlorpheniramine base 14.85 0.594 Liquid drum 0.2 21 4.2 7
56. Cis-Bromo Benzoate 7.2 0.288 solid bag 0.05 41 2.05 7
57. Citric Acid
6.341 0.25364 solid bag 0.05 36 1.8 7
Monohydrate
58. Cyclohexane 39.128 1.56512 Liquid drum 0.2 55 11 7
59. Di bromo di methyl
15.99 0.6396 solid bag 0.05 90 4.5 7
hydantoin
60. Dimethyl formamide 219.6 8.784 Liquid drum 0.2 308 61.6 7
61. Dicyano diamide 12.6 0.504 solid bag 0.05 71 3.55 7
62. Diethanol amine 25 1 liquid drum 0.2 35 7 7
63. diethyl 2-propyl-1H-
imidazole -4,5- 44.5 1.78 liquid drum 0.2 63 12.6 7
dicarboxylate
64. Diethyl amino ethanol 41.652 1.66608 Liquid drum 0.2 59 11.8 7
65. Diisopropyl ether 110.208 4.40832 Liquid drum 0.2 155 31 7
66. Dimethyl amine HCl 14.742 0.58968 solid bag 0.05 83 4.15 7
67. Dimethyl amino ethyl
6.3 0.252 solid bag 0.5 4 2 7
chloride
68. Dimethyl amino 37.5 1.5 Liquid drum 0.2 53 10.6 7

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ethanol
69. Dimethyl amino
33.5 1.34 Liquid drum 0.2 47 9.4 7
propanol
70. Dimethyl sulphate 31.32 1.2528 Liquid drum 0.2 44 8.8 7
71. Disodium EDTA 0.3 0.012 solid bag 0.05 2 0.1 7
72. Dipropyl malonic acid 40 1.6 solid bag 0.05 224 11.2 7
73. Ethylene dichloride 274.8 10.992 Liquid drum 0.2 385 77 7
74. Ethanol 35.55 1.422 Liquid drum 0.2 50 10 7
75. Ethyl acetate 229.5 9.18 Liquid drum 0.2 322 64.4 7
76. Formamidine 0.84 0.0336 solid bag 0.05 5 0.25 7
77. Glycine 32.33 1.2932 solid bag 0.05 182 9.1 7
78. Hydrazine Hydrate 1.08 0.0432 Liquid drum 0.2 2 0.4 7
79. Hydrochloric Acid 205.676 8.22704 Liquid drum 0.2 288 57.6 7
80. Hydrogen Bromide 2.4 0.096 Liquid drum 0.2 4 0.8 7
81. Hydrogen peroxide
27.84 1.1136 Liquid drum 0.2 39 7.8 7
(30%)
82. hydroxylamine
7.74 0.3096 solid bag 0.05 44 2.2 7
hydrochloride
83. Hydrzobenzene 15.62 0.6248 solid bag 0.05 88 4.4 7
84. Hyflo 1.21 0.0484 solid bag 0.05 7 0.35 7
85. Indolenone 18.17 0.7268 solid bag 0.05 102 5.1 7
86. Isopropyl alcohol 77.7 3.108 Liquid drum 0.2 109 21.8 7
87. IPA HCl 34 1.36 Liquid drum 0.2 48 9.6 7
88. L-Tartaric acid diethyl
8 0.32 Liquid drum 0.2 12 2.4 7
ester
89. L-Valine 28.8 1.152 solid bag 0.05 162 8.1 7
90. Mandelic acid 10.9752 0.439008 solid bag 0.05 62 3.1 7
91. Maleic acid 7.92 0.3168 solid bag 0.05 45 2.25 7
92. Mono Chloro benzene 153.1 6.124 Liquid drum 0.2 215 43 7
93. Maltol 59.1 2.364 solid bag 0.05 331 16.55 7
94. Methane Sulfonyl
1.68 0.0672 Liquid drum 0.2 3 0.6 7
Chloride
95. Methanol 611.6 24.464 Liquid drum 0.2 857 171.4 7

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96. Methyl magnesium

48.95 1.958 Liquid drum 0.2 69 13.8 7
chloride
97. Methyl Tert Butyl Ether
71.04 2.8416 Liquid drum 0.2 100 20 7
(MTBE)
98. Methylenedichloride 635.056 25.40224 Liquid drum 0.2 890 178 7
99. Methylmagnesium
12.304 0.49216 Liquid drum 0.2 18 3.6 7
bromide
100. N-Bromo succinamide 33.58 1.3432 solid bag 0.05 189 9.45 7
101. n-Buthyl Alcohol 3.24 0.1296 Liquid drum 0.2 5 1 7
102. N-Butyl diethyl
19.58 0.7832 Liquid drum 0.2 28 5.6 7
malonate
103. N-Chloro acetyl 2,6-
dichloro diphenyl 18.4 0.736 solid bag 0.05 104 5.2 7
amine
104. n-Hexane 278.4 11.136 Liquid drum 0.2 390 78 7
105. Nicotinic acid 40 1.6 solid bag 0.05 224 11.2 7
106. OTBN 20.5 0.82 solid bag 0.05 115 5.75 7
107. Ortho-
40.25 1.61 solid bag 0.05 226 11.3 7
Chlorobenzotrichloride
108. Otho Chloro Para Nitro
13 0.52 solid bag 0.05 73 3.65 7
Aniline
109. Para toluic acid 20.5242 0.820968 solid bag 0.05 115 5.75 7
110. P-chloro pyridine 3.6 0.144 Liquid drum 0.2 6 1.2 7
111. Phenyl Chloro formate 3.76 0.1504 Liquid drum 0.2 6 1.2 7
112. Phosphorous
202.22 8.0888 Liquid drum 0.2 284 56.8 7
oxychloride
113. Phosphorus Acid 4.347 0.17388 Liquid drum 0.2 7 1.4 7
114. Phosphorous
14 0.56 Liquid drum 0.2 20 4 7
trichloride
115. Potassium butan-2-
11.18 0.4472 solid bag 0.05 63 3.15 7
olate
116. Potassium carbonate 44.28 1.7712 solid bag 0.05 248 12.4 7
117. Potassium hydroxide 10.33 0.4132 solid bag 0.05 58 2.9 7

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118. Potassium phthalamide 27.9186 1.116744 solid bag 0.05 157 7.85 7
119. SABMA 6.8 0.272 Liquid drum 0.2 10 2 7
120. Sodium Azide 16.658 0.66632 solid bag 0.05 94 4.7 7
121. Sodium bicarbonate 42.016 1.68064 solid bag 0.05 236 11.8 7
122. Sodium bisulphite 1.128 0.04512 solid bag 0.05 7 0.35 7
123. Sodium borohydride 2.008 0.08032 solid bag 0.05 12 0.6 7
124. Sodium Carbonate 1.56 0.0624 solid bag 0.05 9 0.45 7
125. Sodium Chloride 48.15 1.926 solid bag 0.05 270 13.5 7
126. Sodium Hydro
0.44 0.0176 solid bag 0.05 3 0.15 7
Sulphide
127. Sodium Hydro Sulphite 0.2 0.008 solid bag 0.05 2 0.1 7
128. Sodium hydroxide* 268.06 10.7224 solid bag 0.1 429 42.9 4
129. Sodium Hypochloride 1.6 0.064 solid bag 0.05 9 0.45 7
130. Sodium meta
5.04 0.2016 solid bag 0.05 29 1.45 7
bisulphate
131. Sodium metabisulphite 32.47461 1.298984 solid bag 0.05 182 9.1 7
132. Sodium Methoxide 19.45 0.778 solid bag 0.05 109 5.45 7
133. Sodium thiosulfate 4.72 0.1888 solid bag 0.05 27 1.35 7
134. Sulfuric acid 5.056 0.20224 Liquid drum 0.2 8 1.6 7
135. Tetra butyl Ammonium
2.17 0.0868 Liquid drum 0.2 4 0.8 7
Bromide
136. Tetrahydrofuran 248.08 9.9232 Liquid drum 0.2 348 69.6 7
137. Thiamine
6.21 0.2484 solid bag 0.05 35 1.75 7
hydrochloride
138. Thiamine
monophosphate 7.59 0.3036 solid bag 0.05 43 2.15 7
chloride
139. Thionyl chloride 64.18 2.5672 Liquid drum 0.2 90 18 7
140. Toluene 807.256 32.29024 Liquid drum 0.2 485 97 3
141. Tributyl Amine 807.256 32.29024 Liquid drum 0.2 485 97 3
142. Triethyl amine 14.876 0.59504 Liquid drum 0.2 21 4.2 7
143. Trityl chloride 42.2 1.688 solid bag 0.05 237 11.85 7
144. Urea 25 1 solid bag 0.05 140 7 7

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145. Valeronitrile 38 1.52 Liquid drum 0.2 54 10.8 7

146. Xylene 50.4 2.016 Liquid drum 0.2 71 14.2 7
147. Zinc chloride 53.81 2.1524 Liquid drum 0.2 76 15.2 7

Solvents Storage Table

SR. RAW STATE TYPE OF MT/M Recovere MT/DA Addition NO CAP TOTAL Inventory
NO MATERIALS OF STORAGE d MT/M Y al OF OF STORA
MATER (BAG/DRUM/TA Solvent UNI STORA GE
IAL NK) Required TS GE
(LIQUID M/Day
/ SOLID)
1. 1,2-
Dimethoxyethan liquid Drum 40.00 38.40
e 1.6 0.064 9 0.2 1.8 3
2. 1,4-Dioxane liquid Drum 42.00 39.48 1.68 0.1008 10 0.2 2 3
3. 2-butanol liquid Drum 11.61 10.75 0.4644 0.0344 3 0.2 0.6 3
4. Acetic acid liquid Drum 79.62 77.04 3.1848 0.1032 17 0.2 3.4 3
5. Acetone liquid Tank 365.16 346.05 14.6064 0.7644 2 10 20 1.369263
6. Acetonitrile liquid Drum 40.112 38.912 1.60448 0.048 9 0.2 1.8 3
7. Benzene liquid Drum 103.5 89.585 4.14 0.5566 27 0.2 5.4 1.304348
8. Bromo-Dimethyl
liquid Drum 23.84 12.72
hydantoin 0.9536 0.4448 10 0.2 2 3
9. Chloroform liquid Drum 73.8 70.71 2.952 0.1236 16 0.2 3.2 3
10. Cyclohexane liquid Drum 39.128 37.56 1.56512 0.06272 9 0.2 1.8 3
11. Diisopropyl 110.20
liquid Drum 100.308
ether 8 4.40832 0.396 27 0.2 5.4 3
12. Dimethyl
liquid Drum 219.6 206.98
formamide 8.784 0.5048 49 0.2 9.8 3
13. Ethanol liquid Drum 35.55 28.44 1.422 0.2844 10 0.2 2 3
14. Ethyl acetate liquid Drum 229.5 219.5 9.18 0.4 50 0.2 10 3
15. Ethylene
liquid Drum 274.8 260.74
dichloride 10.992 0.5624 61 0.2 12.2 1

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16. Isopropyl alcohol liquid Drum 77.7 74.14 3.108 0.1424 17 0.2 3.4 3
17. 10.975 0.43900
Mandelic acid liquid Drum 10.88
2 8 0.003808 3 0.2 0.6 3
18. Methanol liquid Drum 287.2 271.5 11.488 0.628 64 0.2 12.8 3
19. Methylenedichlo 392.34 15.6937
liquid Tank 372.7
ride 4 6 0.78576 2 10 20 1.274392
20. Mono Chloro
liquid Drum 153.1 137.65
benzene 6.124 0.618 37 0.2 7.4 3
21. n-Hexane liquid Drum 278.4 263.09 11.136 0.6124 62 0.2 12.4 3
22. Tetrahydrofuran liquid Drum 248.08 242.912 9.9232 0.20672 52 0.2 10.4 3
23. Toluene liquid Tank 496.21 464.054 19.8484 1.28624 3 10 30 2
24. Tributyl amine liquid Drum 7.94 7.59 0.3176 0.014 2 0.2 0.4 3
25. Xylene liquid Drum 50.4 49.14 2.016 0.0504 11 0.2 2.2 3

Table 1.3(B) - Storage Details of Products

Type/
Productio Category
Name of the n Capacity CAS No. of Product
Sr. No. Said API is used for/End Use of said API
Product (MT/Mont (Product) (API/
h) Intermedi
ate)
1 Olmesartan 144689-63-4 API Anti-hypertensive

2 Benfotiamine 22457-89-2 API to treat diabetic neuropathy.

8
3 Fluconazole 86386-73-4 API Anti -Fungal

4 Rabeprazole 117976-89-3 API PPI

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5 Pantoprazole 102625-70-7 API PPI

6 Losartan potassium 124750-99-8 API Anti-hypertensive

7 Itraconazole 84625-61-6 API Anti-Fungal

8 Pregabalin 148553-50-8 API to treat neuropathic pain

9 Levetriacetam 102767-28-2 API Anti-epileptic

10 Valproic acid 99-66-1 API Anti-epileptic

11 Clotrimazole 23593-75-1 API Anti-Fungal

12 Albandazole 54965-21-8 API anthelmintic

13 Chlorzoxazone 95-25-0 API muscle relaxant

14 Oxyclozanide 2277-92-1 API Veterinary

20
15 Diclofenac sodium 15307-86-5 API NSAID

16 Metformin 657-24-9 API Antidiabetic

17 Niclosamide (vet.) 50-65-7 API Veterinary

Chlorpheniramine
18 113-92-8 API antihistamine
maleate

19 Naproxen sodium 26159-34-2 API NSAID

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20 Phenyl butazone 50-33-9 API NSAID

4,6-Dichloro-2-
Intermedia
21 (propylthio)pyrimi 145783-15-9 platelet aggregation inhibitor
tes
dine-5- amine
Intermedia
22 BROMO-OTBN 114772-54-2 Anti-hypertensive
tes
Intermedia
23 BCFI 83857-96-9 Anti-hypertensive
tes
Intermedia
24 TTBB 124750-51-2 Anti-hypertensive
tes
1-H IMIDAZOLE Intermedia
25 144689-93-0 Anti-hypertensive
ESTER tes
2-NITRO-4-
Intermedia
26 THOICYNAO- 54029-45-7 Anthelmintic
tes
ANILINE
2-CHLORO TRITYL 40 Intermedia
27 42074-68-0 Anti-Fungal
CHLORIDE tes
L-VALINE METHYL Intermedia
28 6306-52-1 Anti-hypertensive
ESTER .HCL tes
Bis(2-
Intermedia
29 chloroethyl)amine 821-48-7 antidepressant
tes
hydrochloride
2-
(Diethylamino)ethy Intermedia
30 869-24-9 antiarrhythmic
l Chloride tes
Hydrochloride
2-
(Dimethylamino)et Intermedia
31 4584-46-7 antihistamine
hyl chloride tes
hydrochloride

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3-
(Dimethylamino)pr Intermedia
32 5407-04-5 Anti-depressant/Anti -angity
opyl chloride tes
hydrochloride
4-(Aminomethyl) Intermedia
33 56-91-7 hereditary angioedema
Benzoic Acid tes
5-Difluoromethoxy-
2-{[(3,4-
dimethoxy-2- Intermedia
34 102625-64-9 Proton Pump Inhibitor(PPI)
pyridinyl)methyl]th tes
io}-
1Hbenzimidazole
2-Chloromethyl 3,4-
Dimethoxy Pyridine Intermedia
35 72830-09-2 PPI
HCl tes

2-Chloromethoxy-
4-(3-Methoxy Intermedia
36 153259-31-5 PPI
Propoxy)-3-Methyl tes
Pyridine
2-[[[4-(3-Methoxy
Propoxy)-3- Methyl
Intermedia
37 Pyridine-2-yl] 117977-21-6 PPI
tes
Methyl] Thio]-1H-
Benzimidazole
Chloro acetyl Intermedia
38 1131-01-7 local anesthetic
Xylidine tes
METHYL Intermedia
39 93-60-7 antihistamine
NICOTINATE tes
68
Total
MT/Month

40 R& D Product 0.5

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68.5
Total MT/Mont
h

Table 1.4 - Identification of Hazards associated with Storage of Raw Materials

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
Acetic acid Handling and storage :
(200 lit. x 156  Acetic acid will be stored in
drums) 200lit in drum and will be
 Toxic by transfer to reactor through
TWA: 10 STEL:  Fire inhalation close system.
 Leakage during
15 (ppm) from /Explosion  Toxic when  Water will not be added to the
handling &
ACGIH (TLV) contact with acetic acid.
transportation of
NFPA Ratings  Toxic drums. skin  The chemical will be kept far
1 Health: 3 Chemicals  Toxic if away from sources of heat,
 Rupture in drums
Flammability: 2 Exposure swallowed flame and sparks.
Reactivity: 0 Risks  Danger of very  Wear appropriate respiratory
Flash point: 40 serious equipment like synthetic apron,
°C irreversible splash goggles, gloves, vapour
effects. respirator
 Eye-wash stations are provided
nearby when handling acetic
acid.

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 In emergency cases where
there is a large spill at the
workplace, wear a self-
contained breathing apparatus
as well as full protective suit for
additional safety.
Fire Fighting Measures:
 Water spray. Polyvalent foam.
Alcohol-resistant foam. BC powder.
Carbon dioxide.
Acetic Handling and storage :
Anhydride TWA: 5 ppm  Acetic anhydride will be stored in
(200 lit. x from ACGIH 200 lit drum and will be transfer to
39drums) (TLV) reactor through close system.
 Highly corrosive to the
 Toxic  Leakage during  Static charge removal i.e. earthing /
skin and eyes
NFPA Ratings: Chemicals handling & bonding will be carried out during
 Toxic when contact with
Health:3; Exposure transportation of transfer of acetic anhydride.
Skin
2 Flammability: 2; Risks drums.  Training will be given to workers
 Causes burns
Instability: 0  Rupture in drums for handling of acetic anhydride.
 Toxic if swallowed
 Fire  Flame proof Electrical fittings will
 Irritating to Skin, Eyes
Flash /Explosion be provided at flammable storage
and Respiratory System
Point:CLOSED area.
CUP: 39°C OPEN  Fencing, caution note, hazardous
CUP: 43°C identification board will be
provided.

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Only authorized person will be
permitted in storage area and
register will be maintained.

Accidental release measures:

 Take up the spill in inert material i.e.
sand. Handle the spill by using
adequate PPEs.
 If on skin : Take off contaminated
clothing, rinse skin with water /
shower
 Safety shower and eye washer will
be installed near storage area.
 Avoid breathing vapors and provide
adequate ventilation.

Fire Fighting Measures:

 Use alcohol-resistant foam, carbon
dioxide, or dry chemical spray
 DO NOT USE WATER to extinguish
fire.
Acetone TWA: 250 ppm  Toxic  Leakage during  Eye: Produces irritation, Handling and storage :
(10 kl x 2 NFPA Ratings: Chemicals handling & characterized by a  Acetone Liquid will be stored in
3 Tank) Health: 2 Exposure transportation of burning, redness, 10KL in tank and will be transfer
Flammability: 3 Risks drums. tearing, inflammation, to tanker to tank and tank to
Instability: 0  Fire Hazard  Rupture in drums. and possible corneal reactor through close pipe

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
injury. system.
Flash Point:  Vapors cause eye  All other materials will be stored
-20 °C irritation. separate from Acetone.
 Skin: May be absorbed  Drums will be stored in a well-
through the skin. ventilated area on a hard dry
Repeated or prolonged surface.
exposure may cause  Contact with skin and eyes will be
drying and cracking of avoided.
the skin.  Concentration in the air regularly
 Inhalation: Inhalation of will be monitored.
high concentrations may
cause central nervous Accidental release measures:
system effects  Contaminated clothing will be
characterized by nausea, removed immediately.
headache, dizziness,  Appropriate Gloves, Protective
unconsciousness and goggles, Protective clothing will be
coma. provided to workers during
handling of Acetone.
 Absorb spill with inert material (e.g.
vermiculite, sand or earth), then
place in suitable container.
 Avoid runoff into storm sewers and
ditches which lead to waterways.

Fire Fighting Measures:

 Quick-acting ABC powder
extinguisher, quick-acting BC
powder extinguisher, quick-acting
class B foam extinguisher, quick-

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
acting CO2 extinguisher will be used
as firefighting.
 Spark-/explosion proof appliances
and lighting system will be used.
Acetonitrile Handling and storage :
(200 lit x 57  Acetonitrile will be stored in 200 lit
drums) drums in storage area and will be
transfer to reactor through close
system.
 All other materials will be stored
separate from Acetonitrile.
 Do not discharge the waste into the
TWA: 20 ppm drain.
 Use spark-/explosion proof
 Leakage during
NFPA Ratings: appliances and lighting system will
handling &  Irritation of the eye
Health:2  Fire be installed.
transportation of tissue.
4 Flammability:3, /Explosion  Precautions against electrostatic
drums.  Risk of aspiration
Instability: 0 Fire ,Toxic charges will be taken.
 Rupture in drums pneumonia.
 Keep away from naked flames/heat.
Flash Point: Keep away from ignition
12.8 °C sources/sparks.
 Avoid contact of substance with
water. Observe normal hygiene
standards.
 Keep drums tightly closed.

Accidental release measures:

 Mark the danger area. Consider
evacuation.

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Seal off low-lying areas.
 Close doors and windows of
adjacent premises.
 Absorb spill with inert material (e.g.
vermiculite, sand or earth), then
place in suitable container.

Fire Fighting Measures:

 Alcohol-resistant foam, BC powder,
Carbon dioxide.
 MAJOR FIRE: Water spray,
polyvalent foam.
Aluminum  Eye: Causes severe eye Handling and storage :
chloride (50 kg burns.  Aluminium chloride will be stored
x 820 Bag)  Skin: Causes skin in 50 kg in Bag and will be transfer
burns. to reactor through close system.
 Ingestion: Causes  Wash thoroughly after handling.
TWA: 2 mg/m3 gastrointestinal tract Use with adequate ventilation.
from OSHA PEL  Leakage during burns. May cause  Water will not allow to get into the
NFPA Ratings:  Toxic/ handling & corrosion and packed container because of violent
5 Health-3 hazardou transportation of permanent tissue reaction.
Flammability-0 s bags. destruction of the  Store in a cool, dry, well-ventilated
Instability-2  Rupture in bags esophagus and area away from incompatible
Flash Point: NA digestive tract. substances.
 Inhalation: Causes  Keep away from water. Separate
delayed lung injury. from organic materials.
Causes severe irritation Fire Fighting Measures:
of upper respiratory  Use water spray to cool fire-
tract with coughing, exposed containers.

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
burns, breathing  Use foam, dry chemical, or carbon
difficulty, and possible dioxide.
coma.  DO NOT USE WATER! Do NOT get
 Chronic: Aluminum water inside containers.
may be implicated in Accidental release measures:
Alzheimer's disease.  Vacuum or sweep up material and
Inhalation of aluminum place into a suitable disposal
containing dusts may container.
cause pulmonary  Clean up spills immediately,
disease. observing precautions in the
Protective Equipment section.
 Avoid generating dusty conditions.
Provide ventilation.
 Do not expose spill to water.
 Use water spray to reduce vapors,
do not put water directly on leak,
spill area or inside container.
Ammonia Inhalation: Handling and storage :
(200 lit x 21 TWA: 25 ppm  May cause  Ammonia will be stored in 200 lit in
drums) respiratory irritation. drum and will be transfer to reactor
 Leakage during  Adverse symptoms through close system.
NFPA ratings:  Toxic
handling & may include the following:,  Adequate ventilation will be
Health: 3 chemicals
transportation of respiratory tract irritation, provided in raw material storage
6 exposure
Flammability: 0 drums. coughing area.
risks
Reactivity: 0  Rupture in drums Eye contact:  Contact with eyes, skin will be
 No known avoided/
significant effects or critical  Appropriate respirator will be
Flash point: N.A.
hazards. provided.
 Adverse symptoms  Eating, drinking and smoking will be

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
may include the following:, prohibited in areas where this
pain, watering, redness material is handled, stored and
Skin contact: processed.
 Causes severe  Workers will wash hands and face
burns. before eating, drinking and smoking.
 Adverse symptoms  All the drums will be stored in a dry,
may include the following:, cool and well-ventilated area &
pain or irritation, redness, away from incompatible materials.
blistering may occur
Accidental release measures:
Small spill:
 Dilute with water and mop up if
water-soluble. Alternatively, or if
water-insoluble, absorb with an
inert dry material and place in an
appropriate waste disposal
container.
Large spill:
 Entry into sewers, water courses,
basements or confined areas will be
avoided.
 Contain and collect spillage with
non-combustible, absorbent
material e.g. Sand, earth, vermiculite
or diatomaceous earth and place in
container for disposal according to
local regulations of via a licensed
waste disposal contractor.

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
Benzene (200 Handling and storage :
lit x 438  Benzene will be stored in 200 lit in
drums) drum and will be transfer to reactor
through close pipe system.
 Contact with any sources of ignition,
flames, heat, and sparks will be
avoided.
 Skin & eye contact will be avoided.
 Inhalation of product vapours or
mists will be avoided.
TWA: 50 ppm  Prolonged or repeated  Contact with any incompatible or
contact may defat and
reactive materials will be avoided.
 Leakage during dry skin, and cause
NFPA Ratings:  Proper personal protective
handling & dermatitis.
Health: 0  Fire equipment will be provided to
transportation of  Harmful if absorbed
7 Flammability:3 /Explosion workers.
drums. through the skin.
Instability: 0 Fire  Thoroughly wash all severely
 Rupture in drums.  Inhalation may cause contaminated clothing before reuse.
respiratory tract
Flash Point: 11 Accidental release measures:
irritation.
°C  Extinguish all ignition sources.
 Cause eye irritation
 Ensure clean-up personnel wear
appropriate personal protective
equipment.
 Dike will be provided for spilled
material.
 Avoid contaminating sewers,
streams, rivers and other water
courses with spilled material.

Fire Fighting Measures:

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Small Fires: Dry chemical, CO2,
water spray or regular foam.
 Large Fires: Water spray, fog or
regular foam.
Benzoyl Handling and storage :
Chloride  Benzoyl will be stored in 20 lit in
(20 lit x 18 drums and will be transfer to
drum) reactor through close system.
 Use only under a chemical fume
 Causes burns by all hood.
exposure routes.  Personal protective equipment will
 May cause allergic skin be provided.
reaction.  Do not get in eyes, on skin, or on
Ceiling:0.5 ppm  Ingestion causes severe clothing.
 Leakage during
NFPA Ratings:  Toxic swelling, severe damage  Do not breathe vapours or spray
handling &
Health: 3 Chemicals to the delicate tissue mist & do not ingest.
transportation of
8 Flammability:2 Exposure and danger of  Keep away from open flames, hot
drums.
Instability: 2 Risks perforation: Symptoms surfaces and sources of ignition.
 Rupture in drums
Flash Point: 93 of allergic reaction may  Do not allow contact with water.
°C include rash, itching,  Keep containers tightly closed in a
swelling, trouble dry, cool and well-ventilated place.
breathing, tingling of  Keep away from heat and sources of
the hands and feet, ignition.
dizziness, chest pain.  Keep away from water.
 Store under an inert atmosphere.

Accidental release measures:
 Wear self-contained breathing
apparatus and protective suit.

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Evacuate personnel to safe areas.
 Ensure adequate ventilation.
 Remove all sources of ignition.
 Do not get in eyes, on skin, or on
clothing.

Fire Fighting Measures:

 Use Carbon dioxide (CO2), Dry
chemical, soda ash or lime.
 Use water spray to cool unopened
containers.
 Do not use water or foam.
Bromine (0.3 Handling and storage :
lit x 1411  Bromine will be stored in 0.3 lit
Bottles) Bottle at cool, well-ventilated area
can
and will be transfer to reactor
cause coughing, trouble
through close pipe system.
breathing, headache,
TWA: 0.1 ppm
irritation
NFPA Ratings:  Leakage during
Toxic
Health: 3 handling &
Chemicals produce burns.
9 Flammability: 0 transportation of
Exposure
Instability: 0 Bottle. avoided.
Risks mist may produce severe
Flash Point: 59  Rupture in Bottle
irritation of respiratory
°C
tract, characterized by
Accidental release measures:
coughing, choking, or
shortness of breath.
put the spilled material in an
appropriate waste disposal.

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NABET Accredited 1.50
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
observing precautions in the Protective
Equipment section. Use water spray to
disperse the gas/vapor. Remove all
sources of ignition. Absorb spill with an
alkaline material such as soda ash or
lime. Carefully scoop up and place into
appropriate disposal container. Provide
ventilation. Do not get water inside
containers.

of Bromine vapours will be absorb

using sodium carbonate / sodium thio
sulphate scrubber.

Fire Fighting Measures:

carbon dioxide, or water spray. For

large fires, use dry chemical, carbon
dioxide, alcohol-resistant foam, or
water spray. Contact professional fire-
fighters immediately. Cool containers
with flooding quantities of water until
well after fire is out.

Caustic soda TLV : Ceiling: 2  Toxic  Leakage during  Causes burns by all Handling and storage :
lye (Sodium mg/m3 Chemicals handling & exposure routes.  Caustic soda will be stored in 200 lit
10. hydroxide)
NFPA Ratings: Exposure transportation of  Ingestion causes severe drum and will be transfer to reactor
(200 lit x 114 Health:3 Risks drums. swelling, severe damage through close system.

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.51
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
drums) Flammability: 0  Rupture in drums to the delicate tissue  Contact with skin and eyes will be
Reactivity: 1 and danger of avoided.
Flash Point: NA perforation  Appropriate PPEs (Personal
 Causes burns by all Protective Equipment’s) will be
exposure routes. provided to workers.
 Formation of dust will be avoided.
 Wash face, hands and any exposed
skin thoroughly after handling

Accidental release measures:

Small Spill:
 Vacuum or sweep up material and
place into a suitable disposal
container. Avoid runoff into storm
sewers and ditches which lead to
waterways.
 Appropriate tools will be used to
put the spilled solid in a convenient
waste disposal container.
 If necessary: Neutralize the residue
with a dilute solution of acetic acid.
Large Spill:
 Entry into sewers, basements or
confined areas will be prevented &
dike will be provided if needed.
 Use water spray to reduce vapors.
Chloroform TWA: 10 ppm  Toxic  Leakage during  Acute (short-term) Handling and storage :
11. (200 kg x 104 NFPA Ratings: Chemicals handling & inhalation exposure to  Chloroform will be stored in 200 lit
drums) Health - 2 Exposure transportation of chloroform is central drums and will be transfer to

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.52
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
Flammability - 0 Risks drums. nervous system reactor through close system.
Reactivity - 0  Rupture in drums depression.  Direct contact with route of
 Chronic (long-term) exposure i.e. Skin & eye will be
Flash Point: N.A. exposure to chloroform avoided
by inhalation in humans  Breathing apparatus will be made
has resulted in effects available for person for handling of
on the liver, including chloroform
depression. Accidental release measures:
 Absorb spill with inert material (e.g.,
sand or earth), then place in suitable
container, waterways, drains and
sewers will be avoided
 Inform the relevant authorities if
the product has caused
environmental pollution (sewers,
waterways, soil or air).
Cyclohexane Eye Contact: Handling and storage :
(200 lit x 55
TWA: 300
 Check for and remove  Cyclohexane will be stored in in
drums) (ppm) from
 Leakage during any contact lenses. 200 lit drums and will be
ACGIH
handling & Immediately flush eyes transfer to reactor through close
transportation with water for at least system.
NFPA Ratings: Flammable
12. of drums. 15 minutes, keeping  Keep away from heat. Keep away
Health:1
 Rupture in
 Skin Contact: from sources of ignition. Ground
Flammability:3,
drums  In case of contact, all equipment containing
Instability: 0
immediately flush skin material.
Flash Point:
with plenty of water.  Do not ingest. Do not breathe
37.8°C
Cover the irritated skin gas/fumes/ vapor/spray. Wear

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.53
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
with an emollient. suitable protective clothing. In
Remove contaminated case of insufficient ventilation,
 clothing and shoes. Wash wear suitable respiratory
clothing before reuse. equipment. If ingested, seek
Serious Skin Contact: medical advice immediately and
 Inhalation: show the container or the label.
 If inhaled, remove to  Avoid contact with skin and
fresh air. If not breathing, eyes.
give artificial respiration.  Store in a segregated and
If breathing is difficult, approved area. Keep container
give oxygen. Get medi in a cool, well-ventilated area.
 attention. Keep container tightly closed
 and sealed until ready for use.
Avoid all possible sources of
ignition.
Accidental release measures:
 Absorb with an inert material
and put the spilled material in an
appropriate waste disposal.
 Flammable liquid, insoluble in
water. Keep away from heat.
Keep away from sources of
ignition. Stop leak if without risk.
 Absorb with DRY earth, sand or
other non-combustible material.
Do not get water inside
container. Do not touch spilled

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.54
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
material. Prevent entry into
sewers, basements or confined
areas; dike if needed. Call for
assistance on disposal
Fire Fighting Measures:
 SMALL FIRE: Use DRY chemical
powder.
 LARGE FIRE: Use water spray or
fog.
Ethyl alcohol Handling and storage :
(200 lit x 50  Ethanol will be stored in 200 lits in
drums) drums and will be transfer to
reactor through close system.
 Static charge removal i.e. earthing /
TWA: 1000 ppm bonding will be carried out during
 Toxic  Irritating to eyes. transfer of Isopropyl Alcohol.
 Leakage during
NFPA Ratings: Chemicals  Breathing difficulties.  Do not pressurize, cut, weld, braze,
handling &
Health - 2 Exposure Symptoms of solder, drill, grind, or expose empty
transportation of
13. Flammability - 3 Risks overexposure may be containers to heat, sparks or open
drums.
Reactivity - 0 headache, dizziness, flames.
 Rupture in drums
 Fire tiredness, nausea and  Workers will be given training for
Flash Point:13.9 /Explosion vomiting. handling of Ethanol.
°C  Ingestion and inhalation will be
avoided.

Accidental release measures:

 Absorb spill with inert material
 Personal protective equipment will

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.55
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
be provided to workers.
 All sources of ignition will be
removed.
 Spark-proof tools and explosion-
proof equipment will be used.

Fire Fighting Measures:

 Water spray, alcohol-resistant foam,
dry chemical or carbon dioxide will
be used as a fire frightening.
 Cool closed containers exposed to
fire with water spray.
 As in any fire, wear self-contained
breathing apparatus pressure-
demand, MSHA/NIOSH (approved
or equivalent) and full protective
gear.
Ethyl acetate Handling and storage :
(200 lit x 322  Ethyl acetate will be stored in 200 lit
 Breathing
in drum and will be transfer to
drums)
TWA: 400 ppm difficulties. May cause
 Leakage during reactor through close system.
NFPA ratings:  Toxic central nervous system
handling &  Ventilate area of leak or spill.
Health: 2  Highly depression: inhalation of
transportation of  Wear appropriate personal
14. flammab high vapor concentrations
Flammability : 3 drums. protective equipment.
le may cause symptoms like
Reactivity: 0  Rupture in drums  Isolate hazard area. Keep
headache, dizziness,
Flash point: -4°c unnecessary and unprotected
tiredness, nausea and
personnel from entering.
vomiting.
Accidental release measures:
 Contain and recover liquid when

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.56
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
possible. Neutralize with alkaline
material (soda ash, lime), then
absorb with an inert material (e.g.,
vermiculite, dry sand, earth) if
possible, and place in a chemical
waste container.
Firefighting measures:
 Water may be ineffective. Use water
spray, alcohol foam, co2, dry
chemical.
Hydrochloric Handling and storage :
Acid (200 lit x  Hydrochloric acid will be stored in
 Eye: May cause 200 lit. in drums and will be
288 drums)
irreversible eye injury. transfer to reactor through close
Vapor or mist may system.
Ceiling: 2 ppm cause irritation and  All other materials will be stored
ACGIH TLV severe burns. Contact separate from Hydrochloric Acid.
 Leakage during with liquid is corrosive
 Adequate ventilation will be
NFPA Ratings: handling & to the eyes and causes
provided in raw material storage
Health – 3  Toxic transportation of severe burns.
15. area.
Flammability –0 drums. Skin: Contact with
 Good ventilation will be provided in
Instability – 0  Rupture in drums liquid is corrosive and
raw material storage area.
causes severe burns
 Appropriate personal protective
Flash Point: and ulceration.
equipment will be provided to
N.A. Ingestion: Causes
workers.
severe digestive tract
burns with abdominal
pain Accidental release measures:
 Safety shower and eye washer will
be installed near storage area.

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.57
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Evacuate personnel to safe areas.
 Do not flush into surface water or
sanitary sewer system.
Fire Fighting Measures:
 Use water spray, alcohol-resistant
foam, dry chemical or carbon
dioxide.
Hydrogen Handling and storage :
Bromide  Hydrogen bromide will be stored in
(200 lit x 4 200 lit in drum and will be transfer to
drums) reactor through close system.
 Wear personal protective
equipment/face protection.
 Product is a corrosive  Do not get in eyes, on skin, or on
material. Use of gastric clothing.
TLV: Ceiling: 2 lavage or emesis is
 Use only under a chemical fume
ppm from ACGIH  Leakage during contraindicated.
hood.
NFPA Ratings: handling &  Possible perforation of
 Do not breathe mist/vapors/spray.
16. Health – 3  Toxic transportation of stomach or esophagus
Do not ingest.
Flammability – 0 drums. should be investigated:
Instability – 1
 If swallowed then seek immediate
 Rupture in drums Ingestion causes severe
medical assistance.
Flash Point: NA swelling, severe
 Soak up with inert absorbent
damage to the delicate
material. Keep in suitable, closed
tissue and danger of
containers for disposal.
perforation
Accidental release measures:
 Use personal protective equipment
as required. Ensure adequate
ventilation.
 Evacuate personnel to safe areas.

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.58
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
Keep people away from and upwind
of spill/leak.
Fire Fighting Measures:
 Use CO 2, dry chemical, dry sand,
alcohol-resistant foam.
Hydrogen Handling and storage :
peroxide  Hydrogen peroxide will be stored in
(200 lit x 39 200 lit in drum and will be transfer
drums) to reactor through close system.
 Wash hands and other exposed
areas with mild soap.
 Good ventilation in process area will
be provided.
ACGIH TWA: 1
 Take any precaution to avoid mixing
ppm
 Leakage during  Causes severe skin with Combustibles.
 Toxic
handling & burns and eye damage.  Do not breathe mist, vapours, spray.
NFPA Ratings: Chemicals
transportation of  Swallowing a small
17. Health:3 Exposure
drums. quantity of this material Accidental release measures:
Flammability: 1 Risks
 Rupture in drums will result in serious  Adequate ventilation will be
Instability: 3
health hazard. provided.
 Absorb spill using an absorbent,
Flash Point:N.A.
non-combustible material such as
earth, sand, or vermiculite. Do not
use combustible materials such as
sawdust.
 Flush spill area with water. Provide
ventilation.
 Do not get water inside containers.
Keep combustibles (wood, paper,

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.59
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
oil, etc.,) away from spilled material.

Fire Fighting Measures:

 Foam, Dry powder, Carbon dioxide,
Water spray and Sand will be used
as fire extinguishing media. In case
of fire.
Isopropyl Handling and storage :
alcohol  Isopropyl Alcohol will be stored in
(200 lit x 109 200 lit drums and will be transfer to
drums)  Exposure to high reactor through close system.
concentrations: Coughing.  Heat / naked Flame and other fire
 Dry/sore throat. causing activity will be strictly
 Central nervous system prohibited near drum storage area.
TWA: 200 ppm depression.  Spark-/explosion proof appliances
 Leakage during  Dizziness, Headache. and lighting system will be used.
NFPA Ratings: handling &  Irritation of the eye  Static charge removal i.e. earthing /
Health - 1  Fire transportation of tissue. bonding will be carried out during
18.
Flammability - 3 /Explosion drums.  Absorption of large transfer of Isopropyl Alcohol.
Reactivity - 0  Rupture in drums quantities: Central  Workers will be given training for
 nervous system handling of Isopropyl Alcohol.
Flash Point:18 °C depression.  Contaminated clothing will be
 Exposure/contact: Red removed immediately.
skin, dry skin, itching,  Handle uncleansed empty drums as
cracking of the skin. Skin full ones.
rash/inflammation.  Do not discharge the waste into the
drain.
 Do not use compressed air for
pumping over.

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.60
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved

Accidental release measures:

 Absorb spill with inert material.
 Stop engines and no smoking.
 No naked flames or sparks. Spark-
and explosion-proof appliances and
lighting equipment.
 Personal Protective Equipment’s
will be provided to workers.

Fire Fighting Measures:

 Water spray, polyvalent foam,
Alcohol-resistant foam, BC powder,
Carbon dioxide will be used in case
of fire.
 Cool drums with water
spray/remove them into safety.

Methanol Handling and storage :

(200 lit x 857  Methanol will be stored in 200 lit
drums) drums at ventilated area and will be
TWA: 200 ppm  Leakage during
transfer to reactor through close
NFPA Ratings: handling &
 Causes burns. system.
Health – 1  Fire/ transportation of
19.
drums.  Limited evidence of a  Fire hydrant system will be installed
Flammability –3 Explosion
carcinogenic effect. Safety shower and eye washer will be
Instability – 0  Rupture in drums
installed near storage area.
Flash Point: 12°C
 Flame proof Electrical fittings will be
provided at flammable storage area.
 Proper selection of MOC for

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.61
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
chemicals storage drums.
 Flame arrestor will be provided on
flammable material storage drum.
 Lightening arrestor on all chimney
and building will be provided
 Hazardous material will be stored
away from the plant and safe
distance will be maintained
 Safety permit system will be followed
for loading, unloading of hazardous
chemical
 Fencing, caution note, hazardous
identification board will be provided
 Only authorized person will be
permitted in storage drum area and
register will be maintained.
n-Hexane Handling and storage :
(200 lit x 390  N-Hexane will be stored in 200
drums) TWA: 25 g/kg liters drum and it will be transfer to
 Toxic  Breathing difficulties. reactor through close system.
(Rat)
Chemicals
 Leakage during  Inhalation of high vapor  Good ventilation will be provided in
handling & concentrations may
NFPA Ratings: Exposure n-Hexane storage area.
transportation of cause symptoms like
20 Health:2 Risks  Keep away from heat and sources of
drums. headache, dizziness,
Flammability: 3  Fire Hazard ignition.
 Rupture in drums. tiredness, nausea and
Instability: 0  Adequate ventilation will be
vomiting.
provided in the n-Hexane storage
 Irritation to eyes & skin.
Flash Point: area.
-22 °C
Accidental release measures:

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.62
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Safety shower and eye washer will
be installed near storage area.
 Appropriate personal protective
equipment will be provided to
workers.
 Evacuate personnel to safe areas.
 Do not flush into surface water or
sanitary sewer system.

Fire Fighting Measures:

 Quick-acting ABC powder, Quick-
acting BC powder, Quick-acting class
B foam, Quick-acting CO2 will be
used as fire extinguishing media in
case of fire.
 Flame proof Electrical fittings will
be provided at flammable storage
area.
 Earthing/bonding will be provided
for static charges.
 Spark-proof tools and explosion-
proof equipment will be provided.
Phosphorous TWA: 0.1 PPM Causes burns by all Handling and storage :
 Leakage during
oxychloride Health: 4, exposure routes.  Phosphorous oxychloride will be
handling &
(200 lit x 284 Flammability: 0, Product is a corrosive stored in 200 lit. drums at ventilated
transportation of
21 drums)  Toxic material. Use of gastric area and will be transfer to reactor
Instability: 2 drums.
lavage or emesis is through close system.
Flash Point:  Rupture in drums.
contraindicated.  Do not get in eyes, on skin, or on
N.A. clothing. Wear personal protective

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.63
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
Possible perforation of equipment/face protection. Use only
stomach or esophagus under a chemical fume hood. Do not
should be investigated: breathe mist/vapors/spray. Do not
Ingestion causes severe ingest. If swallowed then seek
swelling, severe immediate medical assistance. Do
damage to the delicate not allow contact with water. Handle
tissue and danger of under an inert atmosphere.
perforation Accidental release measures:
 Ensure adequate ventilation.
Use personal protective
equipment

Fire Fighting Measures:

 As in any fire, wear self-
contained breathing apparatus
pressure-demand, MSHA/NIOSH
(approved or equivalent) and
full
protective gear. Thermal
decomposition can lead to
release of irritating gases and
vapours.
Phosphoric  Highly  May cause irreversible  Handling and storage :
 Leakage during
acid NFPA Ratings: Toxic eye injury  phosphoric acid will be stored in
handling &
Health: 3  Skin Contact with liquid 200 lit in drum and will be transfer
22 200 lit x 7  Flammab transportation of
drums) Flammability: 1 is corrosive and causes to reactor through close system.
le drums.
Reactivity: 1 severe burns and  Use only under a chemical fume
 Rupture in drums
ulceration. hood. Wear personal protective

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.64
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Causes gastrointestinal equipment.
tract burns  Do not get in eyes, on skin, or on
 Irritation may lead to clothing.
chemical pneumonitis  Do not ingest. Do not breathe
and pulmonary edema vapors or spray mist.
 Keep containers tightly closed in a
cool, well-ventilated place.
 Do not store near
 Combustible materials.
 Eyes: Immediately flush eyes with
plenty of water for at least 15
minutes, occasionally lifting the
upper and lower eyelids.
 Skin: Get medical aid immediately.
Immediately flush skin with plenty of
water for at least 15 minutes while
removing contaminated clothing and
shoes.

Phosphorous  Eye: Causes severe eye Handling and storage :

trichloride TWA: 0.5 ppm burns.  Phosphorous trichloride will be
(200 lit x 20 STEL  Skin: Causes skin stored in 200 lit in drum and well-
 Leakage during
drums) burns. Causes redness ventilated area and will be transfer
NFPA Ratings:  Highly handling &
and pain. May lead to to reactor through close system.
23 Health-4 Hazardou transportation of
the formation of  Wash thoroughly after handling.
Flammability-0 s drums.
blisters. Wash thoroughly after handling.
Instability-2  Rupture in drums
 Ingestion: May be fatal  Follow all MSDS and label
Flash Point: NA if swallowed. Causes precautions even after container is
digestive tract burns emptied because they may contain

T. R. Associates (Ahmedabad) Risk Assessment Report

NABET Accredited 1.65
 M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
with immediate pain, product residues.
swelling of the throat,  Do not get in eyes, on skin, or on
convulsions, and clothing. Keep container tightly
possible coma. closed.
Aspiration of material  Do not ingest or inhale. Do not
into the lungs may allow contact with water.
cause chemical  Fire Fighting Measures:
pneumonitis, which  Do NOT use water directly on fire.
may be fatal. Use carbon dioxide or dry chemical.
 Inhalation: Causes Contact professional fire-fighters
chemical burns to the immediately
respiratory tract.  Accidental release measures:
Causes corrosive action  Absorb spill with inert material (e.g.
on the mucous vermiculite, sand or earth), then
membranes. Inhalation place in suitable container.
may produce burning  Avoid runoff into storm sewers and
sensation, coughing, ditches which lead to waterways.
wheezing, laryngitis,  Clean up spills immediately,
shortness of breath, observing precautions in the
headache, nausea, and Protective Equipment section.
vomiting. Exposure  Provide ventilation.
through inhalation may  Evacuate unnecessary personnel.
result in delayed
pulmonary edema
which may be fatal.
Death may result hours
after initial exposure.
 Chronic: Chronic
exposure may cause

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
effects similar to those
of acute exposure.
Potassium Handling and storage:
hydroxide (50  Potassium Hydroxide will be stored
kg x 58 Bag) in 50 kg bagat dry, cool and well-
ventilated place and will be transfer
to reactor through close system.
 Dust formation will be avoided.
 Contact with eyes, skin will be
Ceiling: 2 mg/m3
avoided.
 Leakage during
 Toxic  Personal protective equipment will
NFPA Ratings: handling &
Chemicals  Causes severe burns by be provided to workers.
Health: 3 transportation of
24 Exposure all exposure routes.
Flammability: 0 Bag.
Risks Accidental release measures:
Instability: 1  Rupture in Bag
  Adequate ventilation will be
provided in raw material storage
Flash Point: N.A.
area.
 Contact with eyes, skin will be
avoided.
 Sweep up or vacuum up spillage and
collect in suitable container for
disposal. Avoid dust formation.

Sodium Azide  Leakage during  Fatal if swallowed Handling and storage :

NFPA Ratings:
(500 kg x 94 handling &  Fatal in contact with  Sodium azide will be stored in 50 kg
Health: 4
transportation of skin Bags and will be transfer to reactor
25 Bag) Flammability: 1  Toxic Bags.  Fatal if inhaled through close system
Reactivity: 2
 Rupture in Bags  May cause damage to Fire Fighting Measures:
Flash Point: NA
organs through  As in any fire, wear self-contained

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
prolonged or repeated breathing apparatus pressure-
exposure demand, MSHA/NIOSH (approved
or equivalent) and full Protective
gear. Thermal decomposition can
lead to release of irritating gases
and vapors.

Sulphuric acid  EYE CONTACT: Handling and storage :

(200 lit x 8 Immediate pain, severe  Sulphuric Acid will be stored in 200
drums) burns and corneal lit drums and will be transfer to
damage, which may reactor through close system.
result in permanent  Good general ventilation will be
blindness. provided to keep vapor and mist
concentrations below the exposure
 SKIN CONTACT: Causes limits.
 Toxic  Leakage during burns, and brownish or  Safety shower and eyewash station
NFPA Ratings: Chemicals handling & yellow stains. will be installed at chemical
Health:3; Exposure transportation of Concentrated solutions handling area.
26 Flammability: 0; Risks drums. may cause second or  Always add acid to water never the
Instability: 2
 Rupture in drums third degree burns with reverse.
severe necrosis.  Sufficient personal protective
Flash Point: N.A. Prolonged and repeated equipment’s will be provided to
exposure to dilute workers.
solutions may cause
irritation, redness, pain Accidental release measures:
and drying and cracking  Cover with DRY earth, sand or other
of the skin. non-combustible material or absorb
with an inert dry material and place
 INHALATION: Causes in a loosely covered plastic or other

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
respiratory irritation appropriate waste disposal
and at high container.
concentrations may  If necessary: Neutralize the residue
cause severe injury, with a dilute solution of sodium
burns, or death. Effects carbonate, lime, or other suitable
of exposure may be neutralizing agent.
delayed. Fire Fighting Measures:
 Quick-acting ABC powder
 INGESTION: Causes extinguisher. Quick-acting BC
severe irritation or powder extinguisher. Quick-acting
burns of the mouth, CO2 extinguisher. Class B foam
throat, and esophagus. (alcohol-resistant); after consulting
specialist.
Thionyl Handling and storage :
chloride  Toxic if inhaled.  Thionyl Chloride will be stored in
(200 lit x 90  Material is extremely 200 lit drums and will be transfer to
drums) destructive to the tissue reactor through close system.
TWA: 1 ppm
of the mucous  Contact with skin, eyes & inhalation
Ceiling  Extremely
 Leakage during membranes and upper of vapors or mist will be avoided.
Toxic
handling & respiratory tract.  Drums which are opened must be
NFPA Ratings: Chemicals
transportation of  Skin May be harmful if carefully resealed and kept upright
27 Health - 4 Exposure
drums. absorbed through skin. to prevent leakage.
Flammability - 0 Risks
 Rupture in drums  Causes skin burns. Eyes  Never add water to this product
Reactivity - 2
Causes eye burns.  Do not breathe gas/fumes/
 Corrosive vapor/spray.
 Causes severe eye
Flash Point:N.A.
burns.  PPEs like Splash goggles, Full suit,
 Ingestion May be Vapor respirator, Boots, Gloves etc.
harmful if swallowed. will be provided

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
Accidental release measures:
 Appropriate respiratory protection
will be provided.
 Breathing vapors mist or gas will be
avoided.
 Soak up with inert absorbent
material and dispose of as
hazardous waste.
 Adequate ventilation will be
provided in the storage area of
Thionyl Chloride.
 Contact with water will be avoided.

Fire Fighting Measures:

 Dry powder, Sulphur oxides,
Hydrogen chloride gas Container
explosion may occur under fire
conditions.

Toluene Handling and storage :

TWA: 20 ppm
(10 KL x 3
 Toxic  Irritation of the eye  Toluene will be stored in 10kl in
Tank)  Leakage during tissue. Tank at good ventilated storage
NFPA Ratings: Chemicals
handling &  Risk of aspiration area and will be transfer to
Health:3 Exposure
Risks
transportation of pneumonia. Nausea, tanker to tank and tank to
28 Flammability: 3
drums. Abdominal pain, reactor through close pipe
Instability: 0  Fire Hazard
 Rupture in drums Irritation of the system.
gastric/intestinal  Adequate ventilation will be
Flash Point:
mucosa. provided in the Toluene storage
4 °C
area.

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Dyke wall will be provided to all
above ground storage drum.
 Contact with skin, eyes, and clothing
will be avoided.
 Good hygiene procedures will be
followed when handling Toluene.

Accidental release measures:

 Appropriate personal protective
equipment’s like Safety Gloves,
Goggles, shoes etc., will be provided
to workers.
 Safety shower and eye washer will
be installed near storage area.
 Evacuate personnel to safe areas.
 Do not flush into surface water or
sanitary sewer system.

Fire Fighting Measures:

 Spark-proof tools and explosion-
proof equipment will be provided.
 Flame proof Electrical fittings will
be provided at flammable storage
area.
 Earthing/bonding will be provided
for static charges.
 Flame arrestor will be provided on
flammable material storage drum
vent.

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Type of
Name of
Sr. Hazard Rating hazard /
material Causes Effect Control Measures proposed
No. Systems Risk
stored
involved
 Quick-acting ABC powder, Quick-
acting BC powder, Quick-acting
class B foam, Quick-acting CO2 will
be used as fire extinguishing media
in case of fire.

Note: Approval from PESO will be obtained for applicable chemicals as per Petroleum classification as indicated in Property
table.

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Table 1.5 – Identification of Process Hazards

Name of Material in the Type of hazard possible Causes Control Measures to be provided
hazardous process / toxic gas release / fire /
process and operation explosion / run away
operation reaction / rupture, etc.
1 Boiler(1*1 Bio Coal  Bursting of boilers  Because of overheating and  Temperature indicator cum controllers
TPH) (1 MT/day)  Fires and explosions / Heat overpressure, failure of will be installed to indicate temperature
Burn structural components due and prevent undesired overheating at the
 Burns from hot surfaces, to metal fatigue, etc.) with inlet and outlet of the system
hot water and escaping possible fires, and injury by  Pressure controller with alarm system will
steam the explosion wave, by be provided
 Mechanical accidents when flying fragments, flames,  Periodic inspection of boilers, to detect
operating pulverizer and steam, excessive noise, etc. failure of components, metal cracking, etc.
stoker in coal-fired boilers  Particularly from fuel leaks will be provided as per Gujarat factory
and; fires of soot; rules and Indian Factories Act.
explosions of gas-air  Only qualified & trained person will allow
mixtures within the boiler handling boiler.
 Fire Hydrant system will be provided to
control during fire
 Periodically review of boiler safety system
(Including safety valve) as per Gujarat
Factory Rules
 Fuel feeding system will be as per Gujarat
Pollution control Board Guidelines.
 Regularly replacement of thermic fluid will
be done

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Name of Material in the Type of hazard possible Causes Control Measures to be provided
hazardous process / toxic gas release / fire /
process and operation explosion / run away
operation reaction / rupture, etc.
 Monitoring of flashpoint of thermic fluid
heater regularly
 Installing Fluid conditioning equipment in
the thermal fluid system
 Accident due to Working at  Falls from ladders, stairs  Work permit system will provided and
Height and elevated platforms followed safety shoes with non-skid soles
will be provided
 Electrocution or electric  Unattended /Loose electric  All electric connection will be flame proof
shocks Connections and spark proof
 Inadequate ventilation /  Poisoning by carbon  Adequate ventilation will be provided
Asphyxia due to breathing monoxide or by other  Periodically check and adjust burners
of oxygen-depleted air combustion products in the operation to prevent carbon monoxide
 Heat stress due to air, particularly in the case generation
humidity of faulty ventilation or
inadequate air supply to
burners
 High Noise Hazard  Excessive continuous noise  Adequate PPEs like ear plug, ear muffs etc.
levels - as high as 94 dBA will be provided to the workers near boiler
area
 All the  Release of heat and  Raw Materials quantity must be controlled
chemicals  Toxic release flammable gases either volumetrically or gravimetrically.
Reactor Vessel described in  Fire  Fire, toxic gas release and  Process control devices must be installed
Raw  Explosion explosion which includes the use of sensors, alarms,
material  Failure of agitator, heating trips and other control systems that either

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Name of Material in the Type of hazard possible Causes Control Measures to be provided
hazardous process / toxic gas release / fire /
process and operation explosion / run away
operation reaction / rupture, etc.
storage and cooling system in the take automatic action or allow for manual
inventory reactor intervention to prevent the conditions for
uncontrolled reaction occurring.
 High Temperature indicator valve and alarm
system must be provided. Auto cut off
system must be provided after reaching of
predetermined maximum safe temperature.
 Pressure gauge must be provided. Safety
Control valve is must be provided.
 The Vessel Emergency Relief vent will
discharge to a suitably designed catch pot or
will be so positioned that people working in
the area and members of the public will not
be in danger if the contents of the vessel are
discharged.
 Use skilled worker
 Mechanical seal in all pumps and reactors
 All raw materials will be transfer through
reactor close pipe system.
 Nitration is exothermic reaction leads to
Reactor Vessel  Fire / explosion Runaway reaction (Increasing runaway reaction. So, entire process of
for •Nitration occurred during the of temperature and finally lead nitration is to be followed as per standard
Manufacturing nitration process to explosion) operating procedure established by
•Improper reaction conditions industry.

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Name of Material in the Type of hazard possible Causes Control Measures to be provided
hazardous process / toxic gas release / fire /
process and operation explosion / run away
operation reaction / rupture, etc.
also lead to runaway reaction  All engineering controls w.r.t nitration
•Failure of scrubber system & process i.e. temperature and pressure
over pressure will lead to controller, jacket surrounding to reactor
explosion hazard etc. will be provided.
 Chilled water to control exothermic
reaction during nitration.
 NOx fumes will be scrubbed in ventury
Scrubber from the Nitration reactor.
 Only trained person will be allocated for
handling nitration process.
 Programmable Logic Controller (PLC)
based control plan will be provided for
Nitration.
 Direct Contact with skin and eyes will be
avoided.
 Appropriate personal protective
equipment’s like Safety Gloves, Goggles,
shoes etc., will be provided to workers.
Periodically inspection of scrubber system
will be carried out.
Reactor Vessel  Exothermic Fire/Explosion Runaway reaction (Increasing  Exothermic reaction leads to runaway
reaction of temperature and finally lead reaction. So, entire process has to be
to explosion) followed as per standard operating
procedure established by industry.
Improper reaction conditions  All engineering controls w.r.t exothermic
also lead to runaway reaction reaction i.e. temperature and pressure
controller, jacket surrounding to reactor

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Name of Material in the Type of hazard possible Causes Control Measures to be provided
hazardous process / toxic gas release / fire /
process and operation explosion / run away
operation reaction / rupture, etc.
Over pressure will lead to etc. will be provided.
explosion hazard  Chilled water circulation to control
exothermic reaction.
 Only trained person will be allocated to
operate.
 Programmable Logic Controller (PLC)
based control plan will be provided.
Appropriate personal protective
equipment’s like Safety Gloves, Goggles,
shoes etc., will be provided to workers.

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1.3.4 Credible Accident Sources / Worst Case Scenarios

Maximum Credible Accident (MCA) scenario indicates most believable,

reasonable, likely or possible accident scenario and damage distance based on it.
MCA scenario takes into account the effect of existing control measures also. It
considers the malfunctioning of the control system, opening of safety
valve/failure of safety valve, leakages from flange joint, pipe line etc. and failing
of some safety devise.

Worst-case scenario (rarely possible) is defined as the release of the largest

quantity of a regulated substance from a single vessel or process line failure that
results in the greatest distance to an end point, e.g. catastrophic failure. It
considers the failure of all control systems and release of the whole mass
resulting in maximum damage.

Based on the storage and properties of the chemicals at the proposed unit, the
some typical scenarios relevant for MCA analysis is given in the following Table
1.6.

Table 1.6 - Scenarios Considered for MCA Analysis (FOR ALOHA RUN CHENICAL)

Mode of Pool Flash Toxic Worst case

Sr. No. Chemical Storage
Fire fire Dispersion scenario
/Quantity
Acetic Acid ((200 lit x 1 56
1 Drums) -- --

Methanol 200 lit x 857

2 Drums) -- --

Toluene (200 lit x 485

3 Drums) --
Acetone (200 lit x 1087
4 drum) --

5 Benzene (200 lit x 438

drum) -- --
Ethyl Acetate (200 lit x 322
6 drum) -- --

Hydrochloric (200 lit x 288

7 acid drum) -- --

Isopropyl (200 lit x 109

8 alcohol drum) -- --

n-Hexane (200 lit x 390

9 -- --
drum)

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1.4 Consequence Modeling

Hazardous incidents start with a discharge of a flammable or toxic material from

its normal containment. Discharge can take place from a crack or fracture of
process vessels or pipe work, an open valve or from an emergency vent. The
release may be in the form of gas, liquid, or two phase flashing of gas-liquid.

1.4.1 Damage Criteria

The storage and unloading at the storage facility may lead to fire and explosion
hazards. The damage criteria due to an accidental release of any hydrocarbon arise
from fire and explosion.

A. Fire Damage

Table 1.7 tabulates the damage effect on equipment and people due to thermal
radiation intensity whereas; the effect of incident radiation intensity and
exposure time on lethality is given in Table 1.8.

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Table 1.7 - Damage Due to Incident Radiation Intensities [2]

Incident Type of Damage Intensity
Sr.
Radiation
No. Damage to Equipment Damage to People
(kW/m2)

 100% lethality in 1 min. 1%

1 37.5  Damage to process equipment
lethality in 10 sec.
 Minimum energy required to
 50% lethality in 1 min.
2 25.0 ignite wood at in definitely long
Significant injury in 10 sec.
exposure without aflame

 Maximum thermal radiation

3 19.0 intensity allowed on thermally
---
unprotected adjoining equipment

 Minimum energy to ignite with a

4 12.5  1% lethality in 1 min.
flame; melts plastic tubing

 Causes pain if duration is

longer than 20 sec. However
5 4.0
--- blistering is un-likely (First
degree burns)

 Causes no discomfort on long

6 1.6 ---
exposures

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Table 1.8 - Radiation Exposure and Lethality

Radiation
Exposure Time
Intensity Lethality (%) Degree of Burns
(seconds)
(kW/m2)

No discomfort even
1.6 -- 0
after long exposure
4.0 20 0 1st
4.0 50 0 1st
8.0 20 0 1st
8.0 50 <1 3rd
8.0 60 <1 3rd
12.0 20 <1 2nd
12.0 50 8 3rd
12.5 -- 1 --
25.0 -- 50 --
37.5 -- 100 --

B. Damage due to explosion

Explosion is a sudden and violent release of energy accompanied by the generation

of pressure wave and a loud noise. The rate of energy release is very large and has
potential to cause injury to the people, damage the plant and nearby property etc.

BLEVE– fireball

A Boiling Liquid Expanding Vapor Explosion (BLEVE) occurs when there is a sudden
loss of containment of a pressure vessel containing a superheated liquid or liquefied
gas. It is sudden release of large mass of pressurized superheated liquid to atmosphere.
The primary cause may be external flame impinging on the shell above liquid level
weakening the vessel and leading to shell rupture. Calculations are done for diameter
and duration offer ball and the incident thermal flux.

Pool Fires and Jet Fires

Pool fires and jet fires are common fire types resulting from fires over pools of liquid or
from pressurized releases or gas and/or liquid. They tend to be localized in effect and
are mainly of concern in establishing potential for domino effects and employee safety.

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ALOHA Models are used to calculate various components - burning rate, pool size, and
flame height, in jet fire modeling the steps followed for the thermal effects are
calculation of the estimated discharge rate, total heat released, radiant fraction/source
view fraction, transmissivity and thermal flux and thermal effects.

Vapor Cloud Explosion

When gaseous flammable material is released a vapor cloud forms and if it is ignited
before it is diluted below its lower explosive limit, a vapor cloud explosion or a flash fire
will occur. Insignificant level of confinement will result in flash fire. The vapor cloud
explosion will result in over pressures.

C. Effect due to toxic gas release

Various approaches are used to determine the consequences of toxic gases:
• IDLH
• ERPG
 AEGL

IDLH (Immediate Danger to Life or Health) is the maximum concentration from

which escape is possible within 30 minutes without any escape-impairing
symptoms or irreversible health effects.

ERPGs (Emergency Response Planning Guidelines) are airborne concentrations of

chemicals that have been evaluated for three levels of emergency response.

AEGL (Acute Exposure Guideline Level) are exposure guidelines designed to help
responders deal with emergencies involving chemical spills or other catastrophic
events where members of the general public are exposed to a hazardous airborne
chemical. (Acute exposures are single, non-repetitive exposures that don't exceed 8
hours.)

1.4.2 Details of Model Used for Consequence Analysis

ALOHA provide output as amount of chemical discharged from the source as well
as its concentration in air it takes into account different levels of concentrations
for a specified chemical.

Software used for calculation is ALOHA (AREAL LOCATIONS OF HAZARDOUS

ATMOSPHERES) which is a computer program designed especially for use by
people responding to chemical accidents, as well as for emergency planning and
training. ALOHA can predict the rates at which chemical vapors may escape into
the atmosphere from broken gas pipes, leaking tanks and evaporating puddles. It
can then predict how a hazardous gas cloud might disperse in the atmosphere
after an accidental chemical release.

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ALOHA provides output as amount of chemical discharged from the source as

well as its concentration in air it takes in to account different levels of
concentrations for a specified chemical. Different concentration levels are given
below:

ERPG 1:
is the maximum airborne concentration below which it is believed that nearly all
individuals could be exposed for up to 1 hour without experiencing other than
mild transient adverse health effects or perceiving a clearly defined,
objectionable odor.

ERPG 2:
is the maximum airborne concentration below which it is believed that nearly all
individuals could be exposed for up to 1 hour without experiencing or
developing irreversible or other serious health effects or symptoms which could
impair an individual's ability to take protective action.

ERPG 3:
is the maximum airborne concentration below which it is believed that nearly all
individuals could be exposed for up to 1 hour without experiencing or
developing life-threatening health effects.

IDLH:
The Immediately Dangerous to Life or Health (IDLH) level. A chemical's IDLH is
an estimate of the maximum concentration in the air to which a healthy worker
could be exposed without suffering permanent or escape-impairing health
effects.

AEGL 1:
is the airborne concentration (expressed as ppm or mg/m3) of a substance above
which it is predicted that the general population, including susceptible
individuals, could experience notable discomfort, irritation, or certain
asymptomatic non sensory effects. However, the effects are not disabling and are
transient and reversible upon cessation of exposure.
AEGL-2
is the airborne concentration (expressed as ppm or mg/m3) of a substance above
which it is predicted that the general population, including susceptible
individuals, could experience irreversible or other serious, long-lasting adverse
health effects or an impaired ability to escape.

AEGL-3
is the airborne concentration, expressed as parts per million (ppm) or milligrams

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per cubic meter (mg/m3), of a substance above which it is predicted that the
general population, including susceptible individuals, could experience life-
threatening health effects or death.

Input data for ALOHA are as below:

Weather Data:
 Average Wind Speed: 5 m/sec & 1.5 m/sec
 Average Ambient Temperature: 42 °C, 22 °C
 Average Humidity: 38 %, 68 %
 Atmosphere Stability Class: D (windy day time), F (Extreme calm, night
time)

Chemical Properties:

Chemical properties of each hazardous chemical stored within premises are

given in Table 1.1.

Storage Details:

Storage quantity and type of storage of chemicals is given in Table 1.3 (A) & (B).

Table 1.10 - Consequence analysis and Damage Distance

(Failure of raw material storage tanks/Drums

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Flammable (Distance in meter) Toxic Dispersion

Flash fire
Fire Ball (BLEVE) (Flammable
Type of Impact
Pool Fire Worst Case Scenario Area of Vapor
(meter) (meter) Cloud)
(meter)
Name of Radiation Intensity
37.5 25 4.0 37.5 25 4.0 UEL LEL ERPG(3)/
Chemical (kW/m2) ERPG(2) ERPG(1)
IDLH
100
Fatalities 50% - 100% 50% - - -
%

Wind Stability
Speed Class

LOC
was 11 meters --- 40 meters --- 111 meters ---
5 D <10 <10 <10 never 18m 62m <10 <10 (250 ppm = (35 ppm = (5 ppm =
excee ERPG-3) ERPG-2) ERPG-1)
Acetic Acid
ded
(200 lit x 1 56
LOC
Drums)
was 27 meters --- 93 meters --- 260 meters ---
1.5 F <10 <10 <10 never 21m 67m <10 <10 (250 ppm = (35 ppm = (5 ppm =
excee ERPG-3) ERPG-2) ERPG-1)
ded
<10 meters --- <10 meters --- 14 meters ---
Methanol
(7200 ppm = (2100 ppm = (530 ppm =
(200 lit x 857 5 D <10 <10 <10 17m 24m 70m <10 <10
AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
Drums)
min]) min]) min])

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<10 meters --- 20 meters --- 55 meters ---

(7200 ppm = (2100 ppm = (530 ppm =
1.5 F <10 <10 <10 19m 27m 76m <10 <10
AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
min]) min]) min])
<10 meter --- <10 meters--- 27 meters---
(3700 ppm = (560 ppm = (67 ppm =
5 D <10 <10 <10 31m 40m 103 <10 <10
AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
Toluene min]) min]) min])
(10 KL x 3 Tank) < 10 meters--- 19 meters --- 83 meters ---
112 (3700 ppm = (560 ppm = (67 ppm =
1.5 F <10 <10 <10 34m 43m <10 13
m AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
min]) min]) min])
< 10 meters--- < 10 meters--- 20 meters ---
(5700 ppm = (3200 ppm = (200 ppm =
5 D <10 <10 <10 24m 31m 84m <10 <10
AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
Acetone min]) min]) min])
(10Kl x 2 Tank) 11 meters--- 11 meters --- 52 meters ---
(5700 ppm = (3200 ppm = (200 ppm =
1.5 F <10 <10 <10 34 44 113 <10 11m
AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
min]) min]) min])
< 10 meters -- < 10 meters --- 36 meters ---
103 - (4000 ppm = (800 ppm = (52 ppm =
5 D <10 <10 <10 31m 40m <10 <10
m AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
Benzene min]) min]) min])
(200 lit x 438 11
10 meters --- 17 meters --- 89 meters ---
drum) meters
112 (4000 ppm = (800 ppm = (52 ppm =
1.5 F <10 <10 <10 34m 43m <10 ---
m AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
(1200
min]) min]) min])
ppm =

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10%
LEL)
< 10 meters -- < 10 meters --- < 10 meters --
103
5 D <10 <10 <10 31m 40m <10 <10 - (10000 ppm (1700 ppm = -(1200 ppm =
Ethyl Acetate m
= PAC-3) PAC-2) PAC-1)
(200 lit x 322
< 10 meters -- 11 meters --- 11 meters ---
drum)
1.5 F <10 <10 <10 23m 32m 86m <10 11m - (10000 ppm (1700 ppm = (1200 ppm =
= PAC-3) PAC-2) PAC-1)
15 meters --- 39 meters --- 93 meters ---
(1100 ppm = (160 ppm = (30 ppm =
5 D <10 <10 <10 NA NA NA <10 <10
Hydrochloric AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
acid min]) min]) min])
(200 lit x 288 44 meters --- 118 meters --- 257 meters ---
drum) (1100 ppm = (160 ppm = (30 ppm =
1.5 F <10 <10 <10 NA NA NA <10 16m
AEGL-3 [60 AEGL-2 [60 AEGL-1 [60
min]) min]) min])
< 10 meters --
< 10 meters --- 10 meters ---
- (12000
5 D <10 <10 <10 25m 33m 87m <10 <10 (2000 ppm = (400 ppm =
ppm = PAC-
Isopropyl alcohol PAC-2) PAC-1)
3)
(200 lit x 109 < 10 meters --
drum) < 10 meters --- 33 meters ---
- (12000
1.5 F <10 <10 <10 27m 36m 94m <10 11m (2000 ppm = (400 ppm =
ppm = PAC-
PAC-2) PAC-1)
3)
< 10 meters -- < 10 meters --- no
Hexane
- (8600 ppm (2900 ppm = recommend
(200 lit x 390 5 D <10 <10 <10 30m 39m 99m <10 <10
= AEGL-3 AEGL-2 [60 ed LOC value
drum)
[60 min]) min]) --- (N/A =

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AEGL-1 [60
min])
no
< 10 meters -- 11 meters --- recommend
108 - (8600 ppm (2900 ppm = ed LOC value
1.5 F <10 <10 <10 33m 42m <10 11m
m = AEGL-3 AEGL-2 [60 --- (N/A =
[60 min]) min]) AEGL-1 [60
min])

Chemicals for ALOHA are selected based on following points:

 Chemicals which are fall under hazardous chemicals as per Manufacture, Storage and Import of Hazardous Chemical
(Amendment) Rules, 2000 MSIHC rule.
 Based on physical properties of chemicals i.e. having higher NFPA Rating imposes more potential hazardous nature. So,
chemical which are having higher NPFA rating are selected.
 Based on higher quantity of storage. Higher quantity of drums. (Whichever has higher potency to cause harm)

Name Chemicals Mode of Storage Flash Petroleum Chemical Class (As NFPA Rating
/Quantity Point Class per MSIHC Rules)
Acetic acid (200 lit. x 156 drums) 43°C B
Health: 3
Hazardous
Flammability: 2
Highly Flammable
Reactivity: 0
Acetone (200 lit. x 1087drums) 20 °C A Health:2
Hazardous ,Toxic
Flammability:3
Highly Flammable
Instability:0
Benzene (200 lit x 438 drums) -11°C A Health: 2
Hazardous, Extremely Flammability:
flammable 3
Instability: 0
Ethyl acetate (200 lit x 322 drums) -4 °C A Very Highly Health: 3

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Flammable, Flammability:
Extremely toxic, 2
Hazardous Reactivity: 0
Hydrochloric Acid (200 lit x 288 drums) NA NA Health: 3
Hazardous, Highly Flammability:
Toxic 0
Reactivity: 1
Isopropyl alcohol (200 lit x 109 drums) 18 °C A Health: 1
Hazardous, Flammability:
Flammable 3
Reactivity: 0
Methanol (200 lit x 857 drums) 9.7 °C A Health: 2
Hazardous, Very Flammability:
Highly Flammable 3
Reactivity: 0
n-Hexane (200 lit x 390 drums) 22 °C A Health: 2
Hazardous, Very
Flammability:
Highly Flammable
3
Hazardous
Reactivity: 0
Toluene (200 lit x 485 drums) 4 A Health- 3
Very Highly Flammability-
Flammable 3
Reactivity-0

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Figure 1.1 – Acetic acid BLEVE(1.5 m/s weather condition – stability class F)

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Figure 1.2 – Acetic acid Toxic Dispersion(1.5 m/s weather condition – stability class F)

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Figure 1.3 – – Acetic acid BLEVE(5 m/s weather condition – stability class D)

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N
Figure 1.4 – – Acetic acid Toxic Dispersion (5 m/s weather condition – stability class D)

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Figure 1.5 – Acetone BLEVE(1.5 m/s weather condition – stability class F)

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Figure 1.6 – Acetone Toxic Dispersion (1.5 m/s weather condition – stability class F)

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Figure 1.7 – Acetone BLEVE (5 m/s weather condition – stability class D)

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Figure 1.8 – Benzene BLEVE (1.5 m/s weather condition – stability class F)

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Figure 1.9 – Benzene Toxic Dispersion (1.5 m/s weather condition – stability class F)

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Figure 1.10 – Benzene BLEVE (5 m/s weather condition – stability class D)

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Figure 1.11 – Ethyl acetate BLEVE (1.5 m/s weather condition – stability class F)

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Figure 1.12 – Ethyl acetate BLEVE (5 m/s weather condition – stability class D)

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Figure 1.13 – Hydrochloric acid Toxic Dispersion (1.5 m/s weather condition – stability class F)

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Figure 1.14 – Hydrochloric acid Toxic Dispersion (5 m/s weather condition – stability class D)

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Figure 1.15 – Isopropyl alcohol BLEVE (1.5 m/s weather condition – stability class F)

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Figure 1.16 – Isopropyl alcohol BLEVE (5 m/s weather condition – stability class D)

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Figure 1.17 – Methanol BLEVE (1.5 m/s weather condition – stability class F)

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Figure 1.18 – Methanol Toxic Dispersion (1.5 m/s weather condition – stability class F)

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Figure 1.19 – Methanol BLEVE (5 m/s weather condition – stability class D)

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Figure 1.20 – N-Hexane BLEVE (1.5 m/s weather condition – stability class F)

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Figure 1.21 – N-Hexane BLEVE (5 m/s weather condition – stability class D)

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Figure 1.22 – Toluene BLEVE (1.5 m/s weather condition – stability class F)

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Figure 1.23 – Toluene Toxic Dispersion (1.5 m/s weather condition – stability class F)

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Figure 1.24 – Toluene BLEVE (5 m/s weather condition – stability class D)

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1.5 Estimation of Effect of Damage / Impact Identification

From the dispersion modeling of Acetic Acid, Acetone, Benzene, and Ethyl
acetate, HCL, Isopropyl Alcohol, Methanol-Hexane and Toluene it is observed
that the threat zone is maximum for Methanol from drum storage. Percentage
fatality from different incident outcome cases and level of concerns are given
below:

Incident Level Treat % Likely hood Magnitude of

Chemical outcome of zone fatality of Impact/
case concern distance occurrence Damage
37.5 21
BLEVE 50 Unlikely Moderate
kW/ m 2 meters
Acetic acid
Toxic 27 Very Moderate
AEGL -3 --
Dispersion meters Unlikely
Moderate
Toxic 11 Very
AEGL -3 --
Dispersion meters Unlikely
Acetone
37.5 34 Very Moderate
BLEVE 50
kW/ m2 meters Unlikely
Toxic 11 Very Moderate
AEGL-3 ---
Dispersion meters Unlikely
Benzene
37.5 34 Very
BLEVE 50 Moderate
kW/ m2 meters Unlikely
Very
37.5 23
Ethyl Acetate BLEVE --- Unlikely
kW/ m2 meters Moderate
Toxic 44 Very
HCL AEGL-3 50 High
Dispersion meters Unlikely
Isopropyl 37.5 27 Very Moderate
BLEVE --
Alcohol kW/ m2 meters Unlikely
37.5 19 Very Moderate
Methanol BLEVE ---
kW/ m2 meters Unlikely
Very
37.5 33
n-Hexane BLEVE -- Unlikely
kW/ m2 meters Moderate
Very
37.5 34
Toluene BLEVE -- Unlikely
kW/ m2 meters Moderate

All the threat zones in the proposed unit are super imposed on Google image. Figure
1.1 to 1.48 shows the map of vulnerable areas corresponding to different individual
outcome cases. These figures give the location, where individual risk is found to be a
maximum at locations within premises. A broadly acceptable level of individual risk as

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per the ALARP (AS LOW AS REASONABLY PRACTICABLE) concept of HSE, UK is 10-
6/year.
1.6 Summary

 It may be noted that in dispersion modeling, the wind direction and air
temperature, atmospheric stability are found to be the deciding factors for
the threat zones.

 The present risk assessment study shows that Proposed unit of M/s. Chemcure
Lifesciences LLP

 Having storages of hazardous chemicals mainly Hexane, Toluene, HCL and

other raw materials as per raw material table could have potential for
damage to those inside and outside the industry. Workers working within
premises of industry as well as of adjoining small unit may affect in case of
accidental leakages of these chemicals.

 Fire modeling shows that the hazardous distances for Hexane: 33 meters and
toluene: 34 meter in worst case scenario which might prevent effective fire-
fighting arrangements to be provided.

 A maximum threat zone of approximately 44 meters is observed in

the case of release of HCL in very calm weather condition. This threat zone
can be shortened by segregate storage.

Proposed Risk Reduction Measures

 Storage Drum of Acetic acid, Ammonia and Acetone, Toluene, Methanol and
storage of tank acetone ,toluene will be installed away from the plant area.
 Threat zone of HCL and Acetic acid can be reduced by decreasing storage capacity
and providing adequate control measures as mentioned in identification of hazard
table no 1.4.
 Inspection of the storage Area as per prefixed inspection schedule for thickness
measurement, joint and weld efficiency etc.
 Visually inspect hoses and fittings prior to use and replace worn, corroded, or
damaged parts.
 Fire hydrant system will be installed.
 Safety shower and eye washer will be installed near storage area.
 Flame proof Electrical fittings will be provided at flammable storage area.
 Hazardous material will be stored away from the plant and safe distance will be
maintained.
 Safety permit system will be followed for loading, unloading of hazardous
chemical.

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 Fencing, caution note, hazardous identification board will be provided.

 Only authorized person will be permitted in storage area and register will be
maintained.
 Wind indicator will be provided at the highest level of the plant to know the wind
direction.
 Automatic sprinkler system for the flammable material area may be provided as
knock on effect in case of fire is possible.
 Containment dykes with proper sloping and collection sumps will be provided so
that any spillages in the bulk storage and other handling areas will not stagnate
and will be quickly lead away to a safe distance from the source of leakage. This
reduces the risk of any major fire on the bulk storages and the risk to the
environment will be minimized/ eliminated.
 Inspection of the storage Area as per prefixed inspection schedule for thickness
measurement, joint and weld efficiency etc.
 Provision of flameproof electrical fittings / equipment’s.
 Proper maintenance of earth pits.
 Strict compliance of security procedures like issue of identity badges for outsiders,
gate passes system for vehicles, checking of spark arrestors fitted to the tank
lorries etc.
 Strict enforcement of no smoking.
 Periodic training and refresher courses to train the staff in safety firefighting.
 Employee training and education is carried out.
 Structural fireproofing in the process area could be considered as a safety measure
in the light of probable spill and fires in the area.
 Emergency drills will be carried out periodically to ensure preparedness must
continue.
 Wind indicator will be provided at the highest level of the plant to know the wind
direction.
 Many operations involve use of highly toxic/flammable materials and these needs
to be documented as SOPs. These must be made and kept updated on priority.
 Extensive training on use of Self Contained Breathing apparatus (SCBAs) must be
ensured for emergency control.
 Many of the raw materials used are either toxic or flammable. It is therefore
important to ensure that these materials are stored in closed, well ventilated
totally safe areas. A fire alarm system (heat and smoke detection) will be provided
for the storage area where the material is stored as toxic fumes arise on
combustion.
 Loose drums of waste materials, often solvent laden, must be removed from the
working areas and close watch kept.
 Proper earthing needs to be provided through plug type systems or through the
agitators/liquid.
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 Ventilation will be provided for any enclosed are where hydrocarbon or toxic
vapors may accumulate. Several such areas were noticed- these may be surveyed
and tackled accordingly.
 All personnel will be trained in handling emergency situations and will be
apprised of their role in handling emergency situation and to ensure adequacy of
the emergency procedures simulated exercise will be carried out. This was found
wanting.
 Flame arrestor will be provided.
 Adequate number of caution boards highlighting the hazards of chemicals will be
provided at critical locations.
 Monitoring of occupational hazards like noise, ventilation, chemical exposure etc.
is carried out regularly and its record is maintained.
 Good housekeeping, use of PPE, Engineering controls, Enclosure processes,
scrubber system, display of safety boards, SOP of loading / unloading, local
exhaust ventilation, safety shower etc. are important safety measures have taken
to keep these chemicals within TLV.
 Appropriate personal protective equipment is to be provided & ensure the usage
of them.
 Workers are trained for safe material handling of hazardous chemicals.
 Prepare & display the safe operating procedure for hazardous chemicals storage,
handling & transporting or using.
 Local Exhaust ventilation and scrubber will be installed where it is required to
reduce fumes, vapors, temperature and heat stress.
 Reduce the level of physical activity by sharing workload with other or by using
mechanical means.

 Following FIRE safety devices will be PROVIDED to protect from any

malfunctioning of plant equipment. Following fire protection systems is suggested.

 Water storage of adequate capacity to meet the requirements of water for

firefighting purposes.
 Fire hydrants and automatic sprinkler system. Diesel driven pumps and headers to
supply water to fire hydrant network.
 Adequate Portable fire extinguishers, sand bucket, wheeled fire & safety
equipment will be provided at the required places.
 Equipment required for personal safety like blankets, gloves, apron, gum boots,
face mask helmets, safety belts, first aid boxes etc. are provided. Proximity suits
and self-contained breathing apparatus to be provided.

1.7 Occupational Health Surveillance Program

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 Introduction
Medical surveillance program (also termed as medical surveillance for workers)
can aid in the early recognition of a relationship between exposure to a hazard and
disease, in the assurance of the safety of new substances, and as an indicator of the
effectiveness of existing control measures. It is the systematic collection, analysis,
and dissemination of disease data on groups of workers and is designed to detect
early signs of work-related illness.

The Factories Act, 1948 and the rules framed there under provide for pre-
employment and periodical medical examinations of workers employed in
industries with hazardous processes and dangerous operations under section 41-C
and section 87 respectively. Chemicals Exposed to Workers directly or indirectly
are shown as above chemicals as described in raw material storage inventory. Pre-
employment medical checkup and periodically medical examination will be done.
Liver function testis will be carried out during pre-placement and periodical
examination. In addition to the above, following safety equipment will be provided.

 Action plan for Occupational Health and safety of workers

 Monitoring of occupational hazards like noise, ventilation, chemical exposure
etc. will be carried out regularly and its record will be maintained.
 Good housekeeping, use of PPE, Engineering controls, Enclosure processes,
display of safety boards, SOP of loading / unloading, local exhaust ventilation,
safety shower etc. All necessary safety measures will be taken to keep all
chemicals within TLV.
 Appropriate personal protective equipment will be provided & ensure the
usage of them.
 Workers will be trained on safe material handling of hazardous chemicals.
 Prepared & display the safe operating procedure for hazardous chemicals
storage, handling & transporting or using.
 Periodical medical examination of the workers & Liver Function Testes will be
done.
 Register (Form no.37) for work place air monitoring will be done regularly.
 Employee training and education will be carried out regularly.
 Control the noise at source by substitution, isolation, segregation, barriers will
be done.
 Local Exhaust ventilation will be installed where it is required to reduce fumes,
vapors, temperature and heat stress.

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1.7.1 Treatment Facilities Provided to Workers affected by accidental Spillage of

Chemicals

The first aid treatment facilities will be provided at the factory site. The first aid
box with requisite drugs for burn, etc. will be provided at the production site to
meet any eventuality.

Hazards with Acute Exposure

 Contact with skin may cause severe burns or systemic poisoning.

 Systemic effects may occur from any route of exposure, especially after skin
absorption.

Hazards with Chronic Exposure

 Repeated or prolonged exposure may harm the respiratory system. Can

irritate and inflame the airways.
 Special Safety Precautions
 Prevent contact with skin by wearing neoprene gloves, lab coat, and resistant
apron.
 Wear safety glasses or a face shield if splashing may occur.
 Store in a cool, dry, well-ventilated area, away from heated surfaces or
ignition sources.
 Skin contact requires immediate washing of the affected area with soap and
water.
 Remove contaminated clothing and launder before wearing again.
 Procedure for treating workmen after skin contact:
 Skin contact requires immediate flushing of the contaminated area with soap
and water at a sink or emergency shower for a good fifteen minutes. Remove
contaminated clothing. In case of eye contact, promptly flush the eyes with
copious amounts of water for 15 minutes (lifting upper and lower lids
occasionally) and obtain medical attention. It is recommended to provide the
safety shower and eyewash station in plant.

1.7.2 Minimization of the Manual Handling of Hazardous Substance

Employers and employees will examine their workplaces to detect any unsafe
or unhealthful conditions, practices, or equipment and take corrective action.
Provide flameproof electrical motor & transfer chemicals through the pipelines.
Use specially designed pallets to hold, move raw materials, finished products

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through work areas. Minimize lifting of raw materials, heavy loads by using
appropriate platforms, trolleys, etc. Avoid the moving, manual handling of
hazardous material. The automatic material transfer systems will be provided
wherever possible.
1.7.3 DO’S and DONT’S
Handling of Chemicals

Do’s Don’ts
 Know the hazards of the chemical before  Do not store the chemicals that are
handling. incompatible with other chemicals.
 Know the antidotes for chemical, which you  Do not spill the chemicals.
are handling.  Do not dispose chemical without
 Do keep material safety data sheet in neutralizing.
locations where chemicals are being  Do not keep large inventory of
handled and study it. chemicals.
 Use appropriate personal protective  Do not allow empty containers of
equipment like gloves, aprons, and hazardous chemicals to be used by
respirator; face shield etc. depending upon others.
nature of the work.  Do not use compressed air for
 Label every chemical that you use and transferring chemicals.
tightly close the container.  Do not stand near chemical transfer
 Use eye wash fountain / safety shower in pump while it is in operation with
case of splash of chemicals in the eye or temporary hose connection.
body for at least 15 minutes.  Pouring of chemicals by hand or doing
 Segregate toxic, flammable chemicals and siphoning by mouth will never be
keep them under control. adopted.
 In addition to draining and closing valves,  Chemicals drums will never be moved
lines will be blanked before taking up without protection.
maintenance work.  Do not attempt to neutralize the acid /
 Provide proper ventilation at the chemical alkali on the skin. Use water only.
handling area to limit their concentration  Do not use solvent for cleaning hands.
within prescribed level.

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Material Handling

Do’s Don’ts
 Use proper lifting tool and tackle having  Do not use the equipment for the
adequate capacity. purpose other than its design
 Only authorized persons will operate intention.
material handling equipment’s.  Do not allow personnel to move
 Each tool, tackle or equipment will have underneath lifted load.
number and safe working load (SWL)  Do not load the equipment above its
marked on it. safe working load.
 Assess weight of the material, distance to be  Do not use makeshift arrangements
carried and hazards etc. before lifting the for lifting equipment without
load. inspection and test.
 Inspect and test all the lifting tools and  Do not use defective tool and tackles.
tackles regularly as per Factory Rules.  Keep the tools & tackles free from
 Wear Personal Protective Equipment’s adverse effect of atmosphere by
while handling of material. applying suitable protective coating.
 Wherever possible, mechanized material  The angle between the legs of two leg
handling will be adopted. sling will not exceed 90 degree.
 While lifting a load physically, keep the load  Do not allow male and female adult to
as near as possible to the body with feet lift a load manually higher than 55 kgs
properly placed for body balance. and 30 kgs respectively.
 Bend knees, keep back straight, keep the  Do not hold the load with tip of the
load closed to the body and lift the load. fingers; grasp the load firmly with
palm.

Fire Prevention

Do’s Don’ts
 Follow ‘NO SMOKING’ sign.  Do not leave flammable material
 Deposit oily rags and waste combustible like acetone, kerosene etc. used as
material in the identified containers and cleaning agent at the work area.
dispose them suitably.  Do not over tighten fire hydrant
 Fire Hose used for any other purpose will be valves with F-lever.
permanently marked and taken out of fire  Do not allow wild grass growth
hydrant system. around storage of the gas cylinders
 Keep minimum inventory of flammable and and switchyard.
combustible substances.  Do not obstruct accessibility to the
 Take permission before breaking or removal fire related equipment.
of fire barrier and ensure subsequent  Do not destroy the inspection tag
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relocation of fire barrier. provided with the fire equipment.

 Check periodically the operability of fixed  Do not misuse fire-fighting
firefighting system. equipment other than intended
 Attend any abnormality / deficiency with fire purpose.
protection system promptly.  Do not store the flammable
 Provide earthling or bonding to prevent material in the open container.
accumulation of static charges to tanks where  Do not use instruments that are not
flammable chemicals are stored / handled. intrinsically safe in the explosive
 Use instruments that are intrinsically safe in atmosphere.
explosive atmosphere.

House Keeping

Do’s Don’ts
 Assign places for everything and maintain  Do not leave combustible materials
things at assigned places. in the work area.
 Clean the area after completion of work.  Do not smoke in the area of work.
 Use aisle space free for personnel and material  Do not allow dust bin to overflow.
movement.  Do not generate extra waste.
 Ensure adequate illumination and ventilation  Do not disturb the safety
for the job. equipment from assigned location.
 Drop paper, plastic, glass, metal and bio-  Do not block emergency switches
medical waste in a separate bin kept for this and on/off switches of the
purpose. equipment by storming of materials
 Know the location where emergency in front of work.
equipment such as first aid box, firefighting  Do not leave cleaning agent like
equipment, SCBA, Stretchers are kept. acetone, isopropyl alcohol,
 Arrest all types of spills such as chemical, kerosene etc. at the work area after
water, oil, air / gas, steam etc. and clean up the completion of work.
area immediately.  Do not block fire exit point by
 Ensure exits are indicated / painted for use storing materials or by means.
during emergency.  Do not leave a spillage unattended.

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1.7.4 Disaster Management Plan

1.7.5 Disaster

A disaster is a catastrophic situation in which the day-to-day patterns of life are, in

many instances, suddenly disrupted and people are plunged into helplessness and
suffering and as a result need protection, clothing, shelter, medical and social care and
other, necessities of life.

There are two types of emergency control plans

(1) On site emergency plan and
(2) Off site emergency or disaster plan.

1.7.6 On-Site Emergency Plan

Objectives of the Plan

1. To protect persons and properly of your factory in case of all kinds of accidents,
dangerous occurrences (Rule 103, Gujarat Factories Rules), emergencies and
disasters happening in or affecting your plant at any time.
2. To inform people and surroundings about above happening if it is likely to
adversely affect them.
3. To inform authorities including helping agencies (doctors, hospitals, fire, police,
transport etc.) in advance, and also at the time of actual happening.
4. To identify, assess, foresee and work out various kinds of possible hazards, their
places, potential and damaging capacity and area in case of above happenings.
Review, revise, redesign, replace or reconstruct the process, plant, vessels and
control measures if so assessed.
5. To work out a plan with detailed instructions to cope up with above happenings,
based on your personnel, equipment and records. Levels of hazardous substances
will be minimised to the extent possible. Establish machinery for rescue and
recuperation operations, total loss control and prevention of harms and
recurrence of above happenings. Ensure that absolute safety and security is
achieved within the shortest time.

1.7.7 Site Plan of the Factory and Surrounding

Existing unit has prepared a plan of the factory premises and surroundings showing
therein the areas of various hazards such' as fire, explosion, toxic release etc., and also
location of assembly points, equipment room, personal protective equipment room,
telephone room, first aid or, emergency control room, main gate, emergency gates,
normal wind direction, north direction..

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1.7.8 Types of Overall Emergencies

Fire (small and big), explosion, toxic exposure, strike, storm, flood and other hazardous
possible situations will be described with reasons. Sources of hazard from outside or
neighboring plants, drums, structure etc. will be mentioned.

Table 1.12 - Types of Emergencies

Type of emergency People and
Sr.
including disaster May arise due to At (Place) area likely to
No.
(Major Class) be affected
Spillage or leakages at
Plant Operator,
storage drum Storage area of
1 Fire Labors, workers
Leakages/ reactor raw materials
Admin staff
leakages

Failure of the safety

Plant Operator,
valve/pressure relief
Labors, workers
valve, corrosion of
2 Explosion Steam Boiler Admin staff,
critical parts of the
nearby area or
Steam boiler, or low
vicinity
water level.

Plant Operator,
Labors, workers
Release of Toxic Leakages from Storage area,
3 Admin staff,
Gas/Vapor drum/pipes/valves process area
nearby area or
vicinity
Plant Operator,
Spillage of flammable Loading and Storage area,
4 Labors, workers
liquid/gas unloading process area
Admin staff
Plant Operator,
Deliberate Sabotage, Labors, workers
5 Terrorism, Air Raid - - Admin staff,
etc. nearby area or
vicinity
Plant Operator,
Natural Calamities: - Labors, workers
6 Lightening, Storm, - - Admin staff,
Earthquake, Flood etc. nearby area or
vicinity

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Type of emergency People and

Sr.
including disaster May arise due to At (Place) area likely to
No.
(Major Class) be affected
Collapsing of structure Plant Operator,
Overturning of drum Labors, workers
7 containing - - Admin staff,
flammable/toxic nearby area or
substances vicinity

1.7.9 Assessment of In-plant Hazards

Detailed hazard assessment of in-plant and control measures provided in Section 1.3,
Table No. 1.3 & 1.4 of EIA report. Storage Hazards and Controls, Process Hazards
and Controls are described in same topic.

Information on the preliminary hazard analysis:

System elements or events Hazards

Sr. Type of Safety relevant
that can lead to a major
No. Accident components
accident
 Adequate Safety
Formation of an
valve
explosive
 Vessel, corrosion
Acetone, Ethyl Acetate, atmosphere due to :
Fire / protection
1. Acetic Acid, Ethanol, Isopropyl
explosion  Pressure gauge
alcohol ,Ammonia  Faulty safety valve
sprinkler system
 Corroded vessel
 Fire hydrant
 Overpressure
system
Toxic Gas release
due to :  Adequate Safety
valve
 Faulty safety valve  Use of Seal less
Acetone , Ethyl acetate, ,Acetic
 Glands/seal leaks pumps
Toxic gas acid, Chloroform, Acetic
2. in valves, pumps  Adequate
Release Anhydride, Ammonia,
Hose/pipe failure, scrubber for gas
Isopropyl alcohol, HCl
leakage release control
 Overflow from  Perform LDAR at
storage Drums. regular interval
 Failure of APCM
1.7.10 Emergency Control System

Emergency Organizations and Functions

Key personnel of the organization and responsibilities assigned to them in case of

an emergency

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Sr.
Name of Partner Responsibility
No.
Mr. Mohitkumar kishorbhai
1 Main Controller 1
dedania
Mr. Akash rameshkumar Main Controller 2
2
makadia
Incident Controller 1
3 Mr. Khilan jayantilal godhani
As indicated in below
4 All other key Personnel table; they are responsible
to handle emergency
situation.

The organizational set-up is necessary for chain of commands during emergency

situation, which may arise in the premises. The system is described in following
Subsections.

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Organizational Set-up
Organizational Set-up

Director / Main Controller

 Overall responsible for Emergency situation
 Internal and external communication
 Direct and control rehabilitation of affected area
after emergency

Plant Manager / Incident Controller / EHS Officer

 Next responsible officer after the Main
Controller
 Will give direction to stop all operations within
the affected area
 Evacuation of workers and staffs from affected
area

Plant Supervisor & Staff Security and Fire Officer

 Use of appropriate PPEs at  Responsible for the firefighting /
relevant place rescue facility
 Approach to a  Emergency alarm / siren
 assembly point  Communicate with incident
 Communicate with Plant Manager controller regarding situation
 Mock drill & record keeping at
relevant time interval

Members of above teams will be available during all shifts and holidays. Protective
equipment, lifting gears, fire control points etc.; will be provided in sufficient numbers
and their locations will be well informed. Necessary vehicles will be kept ready to shift
persons in case of emergency.

A. Emergency Control Room

The facilities available at the Emergency Control Center will include:

I. Internal Telephone & External Telephone:
II. Address and Telephone numbers of the Factory Inspectorate, Gujarat Pollution
Control Board, Police, Fire Brigade, Hospitals and OEP Team Members
III. Manual Fire/Emergency Siren
IV. Siren Actuation Switch
V. Important Address and Telephone Numbers
VI. Emergency Vehicles
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VII. Confined Space Entry Procedure

VIII. List of Antidote/actions to be taken in case of hazardous chemical/materials.
IX. Material Safety Data Sheets of chemicals
X. A copy of On-Site Disaster Management Plan
XI. Plant layout-indicating storage of hazardous materials, layout of fire
Hydrants/extinguishers, entrances/exits, roads etc.
XII. Portable P.A. System, Manual Siren, flood lights, Torches, Pickaxe, Saw, Nylon
Ropes.
XIII. Fire Blankets / Fire Proximity Suit, Breathing Apparatus, First Aid Box etc.
XIV. List of employees with address, telephone number, blood group etc.

Transportation of Hazardous Chemicals

Following Hazardous chemicals will be transported through road transport in

M/s. Chemcure Lifesciences LLP : Hydrochloric Acid, Ammonia ,Acetic acid, Ethyl
acetate, and other raw materials shown in Handling Table .Any of these chemical will
leak or catch fire during transportation, then following precautions will be taken.

Sr. Name of
Handling of Fire emergency Handling of Spill / Leak
No. Chemical
 Use water spray to keep fire-
 Spill may be carefully neutralized with
exposed containers cool.
lime (calcium oxide, CaO). A vapor
Hydrochloric Vapors may be heavier than
1. suppressing foam may be used to
Acid air. They can spread along
reduce vapors. Approach spill from
the ground and collect in
upwind.
low or confined areas.
 Dilute with water and mop up if
water-soluble. Alternatively, or if
 Use water spray, alcohol-
water-insoluble, absorb with an inert
2. Ammonia resistant foam, dry chemical
dry material and place in an
or carbon dioxide.
appropriate waste disposal container.

 Use carbon dioxide (CO2),  Take up liquid spill into inert

3. Acetic acid powder, alcohol-resistant absorbent material, e.g.: sand, earth,
foam to extinguish vermiculite, powdered limestone.
 During a fire, irritating and
highly toxic gases may be
generated by thermal
decomposition or
combustion. Use water  Store in a tightly closed container.
spray to keep fire-exposed Store in a cool, dry, well-ventilated
4. Ethyl acetate
containers cool. Flammable area away from incompatible
liquid and vapor. Vapors are substances. Flammables-area.
heavier than air and may
travel to a source of ignition
and flash back. Use water
spray, alcohol foam, CO2,

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dry chemical
 For small spills absorb with earth,
All The sand or other non-combustible
solvents as Quick-acting ABC powder, CO2 material and transfer to containers for
5. per Raw will be used as fire extinguishing later disposal. For large spills, dike far
material media in case of fires ahead of liquid spill for later disposal,
inventory and follow local emergency protocol
for handling

 List of Safety Equipment required before Emergency during Emergency and after
Emergency

Before Emergency
· Mock drill
· Fire Extinguisher
· Co2 Type
· Dry Powder
· Foam
· Sand Buckets
· Fire Hydrant
· Fire Water Storage Tank
· Jockey Pump
· Automatic sprinkler system
· Wind Indicator
· Assembly Point
· PPEs(blankets, gloves, apron, gum boots, face mask helmets, safety belts,
safety ladders, safety torches, first aid boxes)
· Safety boards
· Periodic training
· Safety shower/ Eye Wash fountains
· Safety officer room(which contain Portable P.A. System, Manual Siren, flood
lights, Torches, Pickaxe, Saw, Nylon Ropes. Fire Blankets / Fire Proximity Suit,
Breathing Apparatus, First Aid)

During Emergency
· Antidotes
· Assembly
· Fire Extinguisher
· Fire hydrant
· On-Site / Off Site emergency tools
· Medical expense
· MoU with Nearest Hospital

After emergency
· Preventive Measure
· Training plan
· Standby safety system

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B. On – Site facilities for emergency control

Fire Emergency: Trained personnel will be employed in all the shifts. The
responsibilities and duties include:
 To fight the fire with available internal firefighting equipment and to stop leakage
of liquid etc.
 To provide personal protective equipment to the team.
 To cordon the area and inform incident controller or site main controller about the
development of emergency.
 To train the persons (essential workers) to use personal protective equipment and
fire-fighting equipment.

In case of fire emergency:

Nearest fire station :Rajkot Fire Station
Distance from Site :27.8 Km
Approximate time to reach site: 25 minute

Nearest Hospital : Primary Healthcare Bamanbore.

Distance from Site : 2.5 Km
Approximate time to reach site: 5 minute

C. Fire Fighting Facilities to be provided on - site

1. Fire Buckets / Fire Extinguishers

Fire buckets and portable fire extinguishers will be provided in all the areas
depending upon the specific needs of the area. Some spare equipment will also be
maintained in the inventory at an identified fire & safety equipment store.
2. Fire Alarm Sirens
 It will be provided to alert all the employees inside the premises about the situation
of an emergency. Alarm and details are given in below table.
ALARM & SIREN
EMERGENCY SIREN TONE :-

In case of emergency the siren will be blown as below

FIRE ______ O ______ O ______ O ______ O ______ O Five Times

COD __ __ __ __ __
E… 15 15 15 15 15
sec sec sec sec sec

GAS Ten Times

LEA ______ O ______ O ______ O ______ O ______ O ______ O ______ O ______ O ______ O ______ O

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K… __ __ __ __ __ __ __ __ __ __
15 15 15 15 15 15 15 15 15 15
sec sec sec sec sec sec sec sec sec sec

ALL CLEAR :- Continuous sound for one minute _______________________________________

TESTING …
`Second Day of every month at 11.00 hrs
… Fire Code followed by All clear siren.

PLACE OF ITS LOCATION: ____________________

3. Sand Buckets
Sand buckets will be provided within the industrial premises in case of emergency
fire. Detail quantity is given in below table.

4. Oxygen Cylinder
Oxygen cylinder will be provided for emergency.

5. Safety Equipment
All types of personnel protective equipment’s required for handling the emergency
will be arranged in the proposed unit. Some of the protective equipment’s are as
follow:
Canister/Cartridge type masks
Dust Masks
PVC suits, Aprons
Safety showers/ Eye Wash fountains
Other personnel protective appliances, like safety glasses, gumboots, helmets, hand
gloves, face shields, safety belts, safety ladders, safety torches, blankets.

6. Details of Fire Extinguishers

Table 1.13 - Fire and Safety Equipments & its Cost

Fire and Safety Costing

Sr. Qty Total Capital
Components Capacity/Nos Costing
No. Required Cost in Lakh
250
1. Jockey Pump 1 52000
RPM(1Nos)
11.24
Electrical (180 lit/min),
2. and diesel (2280 3 150000
pump lit/min)

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Water
3. storage tank 170kl 1 650000
(For Fire)
4. Hose Pipe 7.5m 6 18000
Single Head
5. -- 6 24000
Hydrant Post
Automatic
Sprinkler
6. -- 1 40000
system(Alarm
Valve)
water type
7. Fire 9 lit 6 9000
Extinguisher
CO2 type Fire
8. 5 kg 5 15000
Extinguisher
ABC type
9. Fire 5 kg 6 9000
Extinguisher
Sand Bucket
10. -- 10 10000
Stand
11. Foam 5 kg 5 9750
Dry Chemical
12. 5kg 5 9750
Powder
13. Pump 1 Nos 22 77440
LDAR (Seal
14. Less Valves 1 Nos 46 49680
etc.)
250
15. Jockey Pump 1 52000
RPM(1Nos)
Recurring Cost
Maintenance of
Equipments and
1 -- -- 25000 0.25
Periodic check-
up

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Occupational Health Cost

Sr. Qty Total Capital Cost in

Components Costing
No. Required Lakh

1 Mock drill 2 60,000

2 Safety audit -- 25,000
OHC and medical
and health
3 related -- 50000
periodical check
ups
PPE kits (safety
helmet, safety
glasses, gloves,
4 18 18000
safety shoes, first
aid kit, protective 2.63
jacket,)
5 Anti dots 10 10000
SOP/Emergency
6 preparedness -- 25000
plan
7 Training cost -- 25000
8 Safety boards 4 10000
Safety shower/
9 Eye Wash 5 25000
fountains
10 Miscellaneous -- 15000

Recurring Cost
Safety
training/health
1 awareness 25000
training to
workers
2 Safety audit 25000
OHC and medical 0.8
and health
3 related -- 30000
periodical check
ups

Note: * Quantity of is assumed, however these number of cylinders may changes after
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commissioning of project

D. Assembly Points

The assembly points for gathering workers / Admin staff is fixed and clearly marked as
per the wind direction on plant layout as well as on site. In case of emergency some
locations are considered as Assembly Points. Depending on the wind direction and
location of emergency, Assembly Point is declared. The employees will run across the
wind direction and not against the wind direction.

E. Medical Arrangement

First Aid Boxes will be provided at various strategic locations. Requisite numbers of
employees are trained about First Aid, Liaison with nearest hospitals.

Name Of Drug Antidote

Acetic acid Milk Of Magnesia

Acetone atropine and pralidoxime

Acetonitrile Amyl nitrite

Ammonia There Is No Antidote For Ammonia Poisoning. Treatment Consists Of Supportive

Measures. These Include Administration Of
Humidified Oxygen And Bronchodilators And Airway Management; Treatment Of Skin
And Eyes With Copious Irrigation; And Dilution Of Ingested Ammonia With Milk Or
Water.
Benzene Wash the skin area plenty of water if affected. Freshair or Oxygen, 0.1 mg/kg slowly
through injection resting bed. Don’t apply Epinefrin, Ifridin etc. Don’t apply milk,
vegetable oil or alcohol
Bromine ACIDOCTOR – X, paracetamol, opioids, cardiac glycosides, organophosphates

Caustic soda lye There is no antidote for Sodium hydroxide Various treatments to decrease stricture
(Sodium
hydroxide) formation have been proposed (including administration of ascorbic acid and steroids)
Chloroform Hydrocyanic Acid

ethyl alcohol Fomepizole

Ethyl acetate Rinse Contaminated Clothes (Fire Hazard) With Plenty Of Water. Remove
Contaminated Clothes. Rinse Skin, Eyes And Mouth With Plenty Of Water Or Shower.

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Hydrochloric Acid There Is No Antidote For Hydrogen Chloride Poisoning. Treatment Consists Of Support
Of Respiratory And Cardiovascular Functions
Hydrogen peroxide Hyperbaric oxygen has been used in severe embolization cases

Isopropyl alcohol Antidotes For Toxic-Alcohol Poisoning. The Use Of Ethanol Or, Preferably, Fomepizole
For Alcohol Dehydrogenase (Adh) Inhibition Is A Mainstay In The Management
Of Toxicity Due To Ingestion Of Methanol, Ethylene Glycol, Or Diethylene Glycol.
Methanol Currently, there are two antidotes used to block ADH-mediated metabolism of EG
and methanol: ethanol and fomepizole. Bicarbonate
n-Hexane no known antidotes

Sulphuric acid
Acidoctor-S For Sulphuric Acid Skin Burn

Toluene There Is No Antidote For Toluene, But Its Effects Can Be Treated, And Most Exposed
Persons Get Well. Persons Who Have Experienced Serious Symptoms May Need To Be
Hospitalized.

First Aid/Medical Treatment

 First aid given in case of minor cuts/burns etc.
 In case of Major Accidents, affected person will be shifted to nearest Hospital.
Telephone (Internal)
 Internal Telephone Services throughout the Company
 Emergency contact details listed below.

Emergency contact list Helpline No.

Fire 101
Medical Helpline 108
Ambulance 102
Police 100
Disaster Management Services 108

F. General Procedures and Responsibilities

Mock drill: Mock drills will be carried out regularly to familiarize the staff with their
roles, fire protection equipment/system installed in the plant and use of personnel
protective equipment.

Wind Socks: Wind direction will be determined with the help of installed windsocks.

Procedure on Noticing an Emergency

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 If anybody notices any situation, which may lead to a disaster, will be immediately
inform the Shift In-charge / site controller / Incident Controller / Fire & Safety
Supervisor / Security.
 Take charge of the situation as Incident Controller.
 Rush to the site of emergency to get the correct picture and then to Emergency
Control Center for speedy control over the situation by making an arrangement for
raising the alarm.
 On arrival of Team members, he will assign duties as required and activate the On-
Site Emergency Plan.
 Ensure safety of the plant and the personnel in the plant. He will make an
assessment of the emergency and decide on external assistance.
 Communicate and Coordinate among the Incidents Controller/ Site Controller/
Factory manager/ fire safety supervisor etc. and is final authority on all matters
related with management of emergency such as:
 Firefighting
 Welfare and rescue operations.
 Arrange for Civil/Mechanical/Electrical work during emergency.
 Transport.

EHS/Safety Officer & Security Staff

 Rush immediately to the scene of the fire/emergency, select and set out appropriate
fire/emergency equipment. He will take the below mentioned actions at the earliest
opportunity, if the fire/emergency is not controlled.

 He will, Call the security personnel from their residences for additional manpower if
required.
 Regulate entry and exit of personal required for controlling the fire/emergency.
 Restrict exit of personal required for controlling the fire/emergency.
 Arrange for Personnel Protective Equipment required for the emergency.
 Call, the local Fire Brigade, Police in case of necessity in consultation with the
Incident controller.
 Arrange transport facilities for removal of causalities to dispensary / hospital.
 Take responsibility of law and order.
 Keep detailed records of the incident and progress of operations to fight the
emergency.

Plant Manager

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He will rush to the Emergency Control Centre and collect the information from the
Incident Controller. Further he will,
 Announce the location of the Assembly Point after getting information from
Incident Controller / site controller.
 Take the list of persons to be communicated internally and externally.
 Maintain liaison with the press, government agencies i.e. Police, Fire Brigade etc.
and the neighborhood regarding the emergency under instructions from Incident
Controller.
 Courteously Receive officers from the State Government or neighbors to the
Administration Block only and inform to Incident Controller that they can be
taken care off.
 Take all the steps required for the welfare such as providing tea, snacks,
emergency temporary Medical Center in consultation with the incident
controller/site controller.
 Disclose all the necessary information in the plant and media so as to avoid
rumors and Confusion.
 Also be responsible for the head counts at the Assembly Points.

Supervisor/ Shift in Charge & Security

Proceed to the scene; establish contact with firemen and incident controller to
supplement efforts in firefighting.
Assist in searching casualties and help to remove them to the medical center.
Organize outside assistance in firefighting and rescue operations if required.
Mobilize personal protective equipment and safety appliances and assist personnel
handling emergency in using them.
Keep and check on any new development of unsafe situation and report the same to Site
Main Controller.
Effectively cordon off the emergency area and will prevent unauthorized people
entering the scene.
Permit the Fire tenders or Ambulance requisitioned by Incident Controller to the plant.
Ensure that vehicles and trolleys are sent out of the plant premises.
Ensure that all the employees are conducted out of plant and assembled at Assembly
Point. Control Traffic Movement. Remove tankers, tanker drivers outside.
Entry of unauthorized person is to be prevented.
Arrange for vehicles for shifting casualties and essential workers to safe assembly
points. Collect and preserve evidence to facilitate future inquiries.

1.7.11 Offsite Emergency Preparedness Plan

Offsite emergency plan would follow the onsite emergency plan. When the

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consequences of an emergency situation go beyond the plant boundaries, it becomes an

offsite emergency. As the off-site emergency plan is to be prepared by the Government,
a Central Control Committee or Group will be formed under the Chairmanship of the
area head. For example, we assume a district structure and District Collector (is the
Chairman of the District Control Committee (DCC). Other officers from police, fire,
factory, medical, engineering, social welfare, publicity, railway, telephone, transport and
requisite departments will be incorporated as members.

However, the plant management will provide the public administration with the
technical information relating to the nature, quantum and probable consequences on
the neighboring population. The offsite plan in detail is based on those events, which are
most likely to occur, but other less likely events, which have severe consequences, will
also be considered. Incidents which have very severe consequences yet have a small
probability of occurrence would also be considered during the preparation of the plan.

The roles of the various parties who is directly involved in the implementation of an
offsite plan are described below. Depending on local arrangements, the responsibility
for the offsite plan would either rest with the plant management or with the local
authority.

Figure 1.15: Off-Site Emergency Plan

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Aspects Proposed to be considered in the Offsite Emergency Plan

The main aspects, which will be included in the emergency plan, are:

Organization: Detail of command structure, warning systems, and implementation

procedures, emergency control centres. Names and appointments of incident controller,
site main controller, their deputies and other key personnel.

Communications: Identification of personnel involved, communication centre, call signs,

network, list of telephone numbers.

Specialized Knowledge: Details of specialist bodies, firms and people upon whom it may
be necessary to call e.g. those with specialized fuel knowledge, laboratories.

Voluntary Organizations: Details of organizers, telephone numbers, resources etc.

Fuel Information: Details of the hazardous substances stored and a summary of the risk
associated with them.

Meteorological Information: Arrangements for obtaining details of weather forecasts

and weather conditions prevailing at that time.

Humanitarian Arrangements: Transport, evacuation centres, emergency feeding,

treatment of injured, first aid, ambulances and temporary mortuaries.

Public Information: Arrangements for (a) Dealing with the media press office; (b)
Informing relatives Assessment of Emergency Plan

Arrangements for: Collecting information on the causes of the emergency; and

Reviewing the efficiency and effectiveness of all aspects of the emergency plan.

Role of the Emergency Co-ordinating Officer

The various emergency services would be coordinated by an Emergency Coordinating

Officer (ECO), who is designated by the district collector. The ECO would liaison closely
with the Factory Manager/Safety officer. The ECO has been equipped with address and
phone numbers of important agencies.

a. Role of the Local Authority

The duty to prepare the offsite plan lies with the local authorities. The Emergency

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Planning Officer (EPO) appointed will carry out his duty in preparing for a whole range
of different emergencies within local authority area. This liaison will ensure that plan is
continually kept up to date. It is responsibility of the EPO to ensure that all those
organizations which have been involved offsite in handling the emergency knows of
their role and are able to accept it by having for example, sufficient staff and
appropriate equipment to cover their particular responsibilities. Rehearsals for offsite
plans will be organized by the EPO.

b. Role of Police
Formal duties of the police during an emergency include protecting life and property
and controlling traffic movements. Their functions will include controlling bystanders,
evacuating the public, identifying the dead and dealing with casualties, and informing
relatives of death or injury.

Role of Fire Authorities

The control of a fire will be normally the responsibility of the senior fire brigade officer
who would take over the handling of the fire from the site incident controller on arrival
at the site. The senior fire brigade officer will also have a similar responsibility for other
events, such as explosions. Fire authorities in the region will be appraised about the
location of all stores of flammable materials, water and foam supply points, and
firefighting equipment. They will be involved in onsite emergency rehearsals both as
participants and, on occasion, as observers of exercises involving only site personnel.

c. Role of Health Authorities

Health authorities, including doctors, surgeons, hospitals, ambulances and so on, will
have a vital part to play following a major accident, and they will form an integral part
of the emergency plan. For major fires, injuries will be the result of the effects of
thermal radiation to a varying degree, and the knowledge and experience to handle this
in all but extreme cases may be generally available in most hospitals.

Major off site incidents are likely to require medical equipment and facilities additional
to those available locally, and a medical "mutual aid” scheme will exist to enable the
Assistance of neighboring authorities to be obtained in the event of an emergency.

d. Role of Government Safety Authority

This will be the factory inspectorate available in the region. Inspectors are likely to
satisfy themselves that the organization responsible for producing the offsite plan has
made adequate arrangements for handling emergencies of all types including major
emergencies. They may wish to see well documented procedures and evidence of

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exercise undertaken to test the plan. In the event of an accident, local arrangements
regarding the role of the factory inspector will apply. These may vary from keeping a
watch, to a close involvement in advising on operations.
Figure 1.8 - Off-Site Emergency Plan

Table 1.14 - Off-site Action Plan

Action required to be taken to Responsible Equipment/material
Sr.
mitigate disaster by aid giving agencies for facilities required at site
No.
agency taking action to mitigate emergency
Arrangements for evacuation
A Rescue of persons from zone of
Self-Breathing apparatus
1 influence to predetermined
With spare cylinder
camps
Caution to public by
2 Chemical gas mask
announcement
Police with spare canister
Traffic control by cordoning of
3 Department
the area
Vehicle with PA system
4 Law & order
Request to railway authority for
Transportation for
keeping the nearest railway
5 evacuation of people
gate open & to stop the train sat
the nearest railway station
B Control of fire Self-breathing apparatus
Scrubbing of the flashed off gas with spare cylinders
1
Cloud with water curtain Foam / water fire tenders
2 To rescue trapped persons Gas mask with spare
If fire is big, keep surrounding canisters Limewater
3
Area cool by spraying water District Fire Neck to toe complete
Communication to State Brigade asbestos suit, PVC, hand
4 Electricity Board to continue or gloves, gumboots, safety
cut off electric supply goggles
Communication to water supply Mobile scrubbing system
5 Department for supplying along with suction
water arrangement.
Medical facilities for affected Ambulance with on
fire and
C Persons (first aid and board resuscitation unit,
Public health
treatment) first aid, stretchers
Pollution
Identification of concentration
D Control Gas detector
of Gas in zone of influence
Board
E Removal of debris and damaged Municipal Provide bulldozers

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Action required to be taken to Responsible Equipment/material

Sr.
mitigate disaster by aid giving agencies for facilities required at site
No.
agency taking action to mitigate emergency
structures corporation Provide cranes
F Monitor the incoming and out
1 Going transports Provide traffic police at
Arrange emergency shifting of site
affected persons and Transport Provide emergency
2
non-affected person to department shifting vehicles at site
specified area Provide stock of fuel for
Arrange diesel/petrol for vehicles.
3
needed vehicles
Give all information related to Provide wind direction
G Meteorological aspects for safe and velocity instruments
1 handling of affected area for Meteorologic with temperature
living beings al measurements
Department Mobile van for
Forecast important weather
2 Meteorological parameter
changes, If any
measurements
Representatives of all
Departments are in the local
crisis group; therefore they are
expected to render services Must have all resources at
available with them. Since it is a hand, specially disaster
H group of experts with authority, management plan and its
1 the mitigating measures can be implementation method.
implemented speedily. The All relevant information
representative’s from locals are Local Crises Related to hazardous
also there so that Group industry will available
communication with local with crisis group
people is easy and quick. Newspaper editor will be
The district emergency or a part of the group so that
disaster control officer/ right and timely media
collector will be the president release can be done
2
and he will do mock drill etc. so
that action can be taken in right
direction in time
Collector will be the President All necessary facilities
District
I Of District Crisis Group available at district can be
Crisis
1 therefore all district made available at affected
Group
infrastructure facilities are zone Control of law and

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Action required to be taken to Responsible Equipment/material

Sr.
mitigate disaster by aid giving agencies for facilities required at site
No.
agency taking action to mitigate emergency
diverted to affected zone order situation
All other functions as
2
mentioned for local crisis group

LDAR (Leak Detection and Repair)

It is known that leaking equipment, such as valves, pumps, and connectors, are the largest
source of emissions of volatile organic compounds (VOCs) and volatile hazardous air
pollutants (VHAPs) from chemical manufacturing units. The raw material properties which
emits VOCs are described in Table-1.4

LDAR programme would be applicable to components for following products/compounds:

(i) Hydrocarbon gases; (ii) Light liquid with vapor pressure @ 20°C > 1.0 kPa;]and (iii)
Heavy liquid with vapor pressure @ 20°C between 0.3 to 1.0 kPa

Actually all solvents used for the proposed project of M/s. Chemcure Lifesciences LLP
will be used only for adjustment of viscosity. So no solvent will be generated and
recovered. So no loss of solvents at any stage of project.

Even though the LDAR program for proposed project will be applicable to following
products:

Table 1.15- List of compounds applicable for LDAR

Table 1.14 : List of Volatile organic compounds (VOCs)

Flammable Limit
Chemical Class
Sr. Chemicals/ TLV/ Class NFPA Vapour
FP BP (As per MSIHC
No. Solvent TWA (As per Ratting Pressure
Rules)
°C °C Petroleum
Classification)
Health 2 0.064
1,2- 84 - 86
1 5 ppm 6 °C A Toxic Flammable Flammability kPa @ 20
Dimethoxyethane °C
Hadardous 3 Instability 0 °C
Health 2
101 4.1 Kpa
2 1,4-Dioxane 20 ppm 12 °C NA hazardosu Flammability
°C @ 20 °C
3 Instability 1
Health: 2
TWA: 20 Highly Flammability: 0.67 kPa
3 2-Butanol 35°C 117.6°C B
ppm Flammable 3 @ 20°C
Instability: 0
Toxic, Health: 3
168
4 2-Nitro Aniline N.A 284 °C NA Flammable, Flammability: 3.68 kpa
°C
Hazardous 1 at 25 °C
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Table 1.14 : List of Volatile organic compounds (VOCs)

Flammable Limit
Chemical Class
Sr. Chemicals/ TLV/ Class NFPA Vapour
(As per MSIHC
No. Solvent TWA FP BP (As per Ratting Pressure
Rules)
°C °C Petroleum
Classification)
Reactivity: 2

Health 2
3-methoxy TWA: 50 30 1.453214
5 120 °C B NA Flammability
propanol ppm °C kpa
3 Instability 0
Health: 3
Hazardous
TWA: 10 Flammability: 2.09 kPa
6 Acetic acid 43°C 118°C B ,Highly
15 (ppm) 2 at 25°C
Flammable
Reactivity: 0

Health: 3
Hazardous
TWA: 5 52 Flammability: 0.51 kPa
7 Acetic Anhydride 137 °C B ,Highly
ppm °C 2 at 20°C
Flammable
Reactivity: 0

Health – 2
30.93
TWA: 250 -20 Hazardous ,Toxic Flammability
8 Acetone 56 °C A kPa at
ppm °C Highly Flammable –3
25°C
Instability - 0
Health: 2
Hazardous,Toxic,
81-82 Flammability: 9.7 kPa
9 Acetonitrile NA 6 °C A Highly
°C 3 @ 20°C
Flammable
Instability: 0
Health: 1
0.133
TWA Flammability:
10 Activated Carbon N.A. N.A. N.A. N.A kpa @
10mg/m3 2
3586°C
Reactivity: 0
Ammonium 0.0001
11 N.A N.A N.A N.A N.A N.A
acetate kpa
Health: 2
Hazardous, 9.99 kPa
TWA: 0.5 - Flammability:
12 Benzene 80.1°C A Extremely at @ 20
ppm 11°C 3
flammable °C
Instability: 0
Health: 3
Ceiling: 93 Highly Flammability: 0.05 kPa
13 Benzoyl Chloride 198 °C C
0.5 ppm °C Toxic,hazardous 2 @ 20 °C
Reactivity: 2
Health: 3
23.33
TWA: Flammability:
14 Bromine N.A. 59°C N.A. Hazardous kPa @ 20
0.66 0
0C
Reactivity: 0

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Table 1.14 : List of Volatile organic compounds (VOCs)

Flammable Limit
Chemical Class
Sr. Chemicals/ TLV/ Class NFPA Vapour
(As per MSIHC
No. Solvent TWA FP BP (As per Ratting Pressure
Rules)
°C °C Petroleum
Classification)
Health: 2
TWA: 20 Highly Flammability: 0.67 k Pa
15 Butanal 35°C 117.6°C B
ppm Flammable 3 @ 20°C
Instability: 0
Health: 3,
0.133
Ceiling: 2 1390 Flammability:
16 Caustic soda lye N.A. N.A. Hazardous kpa
mg/m3 °C 0,
@739 °C
Reactivity: 1
Health: 4
Hazardous
-34.05 Flammability: 678.0
17 Chlorine gas 0.5 ppm N.A. N.A ,Toxic
°C 0 kPa 20°C
Hazardous
Instability: 0
Chloro acetyl 6.2 kPa
18 N.A. N.A. 105 °C N.A. Hazardous N.A.
chloride @ 20 0C
Health 2
1 mg/m3 138 0.0013
19 Diethanol amine 268 °C NA Hazardous Flammability
Skin °C kpa
1 Instability 1

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LDAR programmer would not be applicable for,

(i) heavy liquids with vapor pressure < 0.3 kPa, it will be desirable to check for
liquid dripping as indication of leak
(ii) Equipment and line sizes less than 2.54 cm, less than 300 hr service and in
vacuum service.
(iii) Equipment and piping during start up and shut down.
(iv) Pumps (canned, diaphragm, magnetic), Valves (Diaphragm, bellow) and close
loop Sampling points; and
(v) Non accessible points to the extent of 5% of total plant.
Leak detection and repair methods can be applied in order to reduce fugitive emissions
from process unit sources. Leak detection methods are used to identify equipment
components that are emitting significant amounts of VOC. Emissions from leaking
sources may be reduced by three general methods.

1. Repair,
2. Modification
3. Replacement of the source. In the case of open ended lines, however, equipment leaks
are treated more effectively by installation of control equipment.

The source may be checked for leakage by

1. Visual 3. Olfactory

2. Audible 4. Instrument techniques

(Portable hydrocarbon detection instruments are the best method for identifying leaks
of VOC from components)

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LDAR Component survey

Source of
Leakage/Compone
equipment Detection method Repair
nts
leaks
Usually Pump Tightening the
Liquid leaks Visual Method
seal failures packing gland
High pressure
- Audible method
leaks
Odorous
- By smell
material leaks
VOC
Conduct a circumferential
traverse at the outer Use Spare pumps
surface of the pump or at the time of
compressor shaft and seal repair.
interface.
If the source is a rotating Tightening the
shaft, position the probe packing glands
Pumps At seals inlet within 1 cm of the
shaft-seal interface for the The pump will
survey. be flushed of
If the housing VOC as much as
configuration prevents a possible before
complete traverse of the opening for seal
shaft periphery, sample all replacement.
accessible portions
Usually occur
at the stem or Plug type valves
gland area of can be lubricated
the valve body with grease to
Place the probe inlet at
and are reduce emissions.
approximately the center
Valves commonly Many valves have
of the opening to the
caused by a no means of in-
atmosphere.
failure of the service repair and
valve packing must be isolated
or O-ring. from the process.

For welded flanges, place

the probe at the outer edge
of the flange-gasket In some cases,
Gasket failure interface and sample the leaks from
and circumference of the flanges can be
Connectors improperly flange. reduced by
torqued bolts If the source is a rotating replacing the
on flanges. shaft, position the probe flange gaskets.
inlet within 1 cm of the
shaft-seal interface for the
survey.
Sampling At the outlet of Place the probe inlet at
Connections the sampling approximately the center

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valve when of the opening to the

the sampling atmosphere.
line is purged
to obtain the
sample.
Since most
Conduct a circumferential compressors do
traverse at the outer not normally have
Most often
surface of the pump or spares, repair or
Compressors occur from the
compressor shaft and seal replacement of the
seals.
interface. seal would require
a shutdown of the
process.
Installation of a
valve is not rupture disk in the
Sampling at the sealing
seated line prior to relief
seat interface.
properly valve Connection of
Devices equipped with an
operating too the discharge port
Pressure/safety enclosed extension, or
close to the set of the relief valve to
relief valves horn, place the probe inlet
point, a closed vent
at approximately the
if the seal is system
center of the exhaust area
worn or use of Soft seat
to the atmosphere.
damaged. technology such as
elastomer "0-rings.

Details of Solvent recovery

Consumption Recovered Loss %
S.No. Name of Solvent
(MT/M) (MT/M) (MT/M) Recovery
1 1,2-Dimethoxyethane 40.00 38.40 1.60 96.00
2 1,4-Dioxane 42.00 39.48 2.52 94.00
3 2-butanol 11.61 10.75 0.86 92.59
4 Acetic acid 79.62 77.04 2.58 96.76
5 Acetone 365.16 346.05 19.11 94.77
6 Acetonitrile 40.112 38.912 1.20 97.01
7 Benzene 103.5 89.585 13.92 86.56
Bromo-Dimethyl 23.84 12.72 11.12 53.36
8
hydantoin
9 Chloroform 73.8 70.71 3.09 95.81
10 Cyclohexane 39.128 37.56 1.57 95.99
11 Diisopropyl ether 110.208 100.308 9.90 91.02
12 Dimethyl formamide 219.6 206.98 12.62 94.25
13 Ethanol 35.55 28.44 7.11 80.00
14 Ethyl acetate 229.5 219.5 10.00 95.64
15 Ethylene dichloride 274.8 260.74 14.06 94.88
16 Isopropyl alcohol 77.7 74.14 3.56 95.42
17 Mandelic acid 10.9752 10.88 0.10 99.13

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Rajkot, Gujarat-360023

18 Methanol 287.2 271.5 15.70 94.53

19 Methylene dichloride 392.344 372.7 19.64 94.99
20 Mono Chloro benzene 153.1 137.65 15.45 89.91
21 n-Hexane 278.4 263.09 15.31 94.50
22 Tetrahydrofuran 248.08 242.912 5.17 97.92
23 Toluene 496.21 464.054 32.16 93.52
24 Tributyl amine 7.94 7.59 0.35 95.59
25 Xylene 50.4 49.14 1.26 97.50

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Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

The magnitude of solvent loss in all the three medium viz Water, Air & Hazardous
Waste.

Air %
Water % Solid waste %
(transfer loss
S.No. Name of Solvent Loss % (through (Distillation residue
and drying
wastewater) and spent solvent )
loss)
1. 1,2-Dimethoxyethane
4 0.64 1.12 2.16
2. 1,4-Dioxane
6 0.96 1.68 3.24
3. 2-butanol
7.4 1.184 2.072 3.996
4. Acetic acid
3.24 0.5184 0.9072 1.7496
Acetone
5.
5.23 0.8368 1.4644 2.8242
6. Acetonitrile
2.99 0.4784 0.8372 1.6146
7. Benzene
13.44 2.1504 3.7632 7.2576
Bromo-Dimethyl
8.
hydantoin 46.64 7.4624 13.0592 25.1856
9. Chloroform
4.18 0.6688 1.1704 2.2572
10. Cyclohexane 4.007 0.64112 1.12196 2.16378
11. Diisopropyl ether
8.98 1.4368 2.5144 4.8492
12. Dimethyl formamide
5.74 0.9184 1.6072 3.0996
13. Ethanol
20 3.2 5.6 10.8
14. Ethyl acetate
4.35 0.696 1.218 2.349
15. Ethylene dichloride
5.11 0.8176 1.4308 2.7594
16. Isopropyl alcohol
4.58 0.7328 1.2824 2.4732
17. Mandelic acid
0.86 0.1376 0.2408 0.4644
18. Methanol
5.46 0.8736 1.5288 2.9484
19. Methylene dichloride
5.006 0.80096 1.40168 2.70324
20. Mono Chloro benzene
10.09 1.6144 2.8252 5.4486
21. n-Hexane
5.49 0.8784 1.5372 2.9646
22. Tetrahydrofuran
2.08 0.3328 0.5824 1.1232
23. Toluene
6.48 1.0368 1.8144 3.4992
24. Tributyl amine
4.4 0.704 1.232 2.376
25. Xylene
2.5 0.4 0.7 1.35

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M/s. Chemcure Lifesciences LLPPlot
Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

Equipment Component Counts & Uncontrolled VOC Emissions

Average
Uncontrolled Percentage
Average
Components VOC of total Preventive Measures
quantity
Emissions emission
(ton/year)
 Use Sealless design
 Use Dual mechanical seal with
barrier fluid maintained at a
higher pressure than the
pumped fluid
 Provide Closed-vent system
Pumps 22 4.18 44.16  Use Spare pumps at the time of
repair.
 Tightening the packing glands
 The pump will be flushed of
VOC as much as possible
before opening for seal
replacement.
 Use Sealless design.
 Plug type valves can be
lubricated with grease to
Valves 35 1.93 20.39 reduce emissions.
 Many valves have no means of
in-service repair and must be
isolated from the process.
 Weld together
 In some cases, leaks from
Connectors 63 1.06 11.15 flanges can be reduced by
replacing the flange gaskets.
 Use of Blind, cap, plug, or
Open ended
second valve will make 100%
lines 11 0.18 1.87
Control Over Leakage
Sampling
 Provide Closed-loop sampling
Connections 11 1.51 15.98
 Use of Rupture disk assembly
Pressure 11 0.61 6.46 will make 100% Control Over
relief valves
Leakage

Note: The counts of the components may vary at the time of operation according to the
requirement.

The VOC emission limit of the proposed unit is within the given limit.

Newer information suggests that open-ended lines and sampling connections may
account for as much as 5-10% of total VOC emissions from equipment leaks.
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Plot No.514/515/516, Bamanbore GIDC,
Village- Bamanbore, Taluka- Rajkot, District -
Rajkot, Gujarat-360023

(Source: “United States Environmental Protection Agency Office of Compliance Office of

Enforcement and Compliance Assurance 1200 Pennsylvania Avenue, NW (mail code)
Washington, DC 20460)

Following frequency of monitoring of leaks and schedule for repair of leaks will be
followed.
Sr. Equipment component
Component Repair schedule
No. Frequency of monitoring
Quarterly (semiannual
After two consecutive
1 Valves/ Flanges periods with < 2% leaks and
annual after 5 periods
with < 2% leaks)
2 Pump seals Quarterly Repair will be started
3 Compressor seals Quarterly within 5 working days
Pressure relief and will be completed
4 Quarterly
devices within 15 working days
Pressure relief after detection of leak for
5 devices (after Within 24 hours general hydrocarbons.
venting)
6 Heat Exchangers Quarterly
7 Process drains Annually
Components that
8 are difficult to Annually
monitor
Pump seals with
9 visible liquid Weekly Immediately
dripping
Any component
10 Weekly Immediately
with visible leaks
Any component
11 after repair/ Within a week -
replacement

Data on time of measurement & concentration value for leak detection; time of repair of
leak; and time of measurement & concentration value after repair of leak will be
documented for all the components.

EMC (Environmental management cell) will be responsible to perform the monitoring

periodically

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Rajkot, Gujarat-360023

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 Page 1 of 43

Project details

 Synthetic Organic Chemicals 5(f)

(B2 category as per amended EIA Notification dated 27/03/2020)

 For Environmental Clearance [EC]

 New Project :

API and Intermediates

1. Basic Information of the Project:

i Name & Address of the Project site M/s. Chemcure Lifesciences
LLP
(Complete details with plot no./Survey
Plot No.514/515/516, Bamanbore
no., Landmark etc. ) GIDC, Village- Bamanbore,
Taluka- Rajkot, District -Rajkot,
Gujarat-360023
ii Name of the Applicant Mohitkumar Kishorbhai Dedania
iii Address for correspondence CHITRUKUT DHAM, BLOCK NO
186 KALAWAD ROAD, BH IOC
QUATRES, RAJKOT.
iv Contact no. and e-mail ID of the Mo. no. : 9687230287
Applicant e-Mail:
[email protected]
v Longitude & Latitude of the Project
Boundary Geo Co-
Site: (4 corners of the site) Point ordinates
22°24'6.86"N
A
71° 1'27.28"E
22°24'7.49"N
B
71° 1'29.43"E
22°24'5.85"N
C
71° 1'29.94"E
22°24'5.26"N
D
71° 1'29.00"E
22°24'5.27"N
E
71° 1'27.82"E
vi Aerial distance of nearest Habitat (KM) Hirasar : 1.06 Km in W direction
In case of outside GIDC Not applicable
 Ensure that there are no water
bodies, natural drain, National
monuments etc. within 500 m radius
from the project boundary.
 There are no Eco sensitive zones,
wild life sanctuaries within the 10 km

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 Page 2 of 43

area from the boundary of the project

site.
vii Category as per the Schedule to the EIA 5 (f) Synthetic Organic Chemicals
Notification 2006 i.e. 1(d), 2(b), 5(f) etc. Sub-Category: B2 as per the
MoEF&CC’s notification vide
S.O. 1223 (E) dated 27/03/2020.

2. Online application proposal no. : SIA/GJ/IND2/172179/2020

3. Product profile:
Type/
Production
Category of Said API is used
Sr. Capacity CAS No.
Name of the Product Product for/End Use of
No. (MT/ (Product)
(API/ said API
Month)
Intermediate)
144689-
1 Olmesartan API Anti-hypertensive
63-4
22457- to treat diabetic
2 Benfotiamine API
89-2 neuropathy.
86386-
3 Fluconazole API Anti -Fungal
73-4
117976-
4 Rabeprazole API PPI
89-3
8 102625-
5 Pantoprazole API PPI
70-7
124750-
6 Losartan potassium API Anti-hypertensive
99-8
84625-
7 Itraconazole API Anti-Fungal
61-6
148553- to treat
8 Pregabalin API
50-8 neuropathic pain
102767-
9 Levetriacetam API Anti-epileptic
28-2

10 Valproic acid 99-66-1 API Anti-epileptic

23593-
11 Clotrimazole API Anti-Fungal
75-1
54965-
12 Albandazole API anthelmintic
21-8

13 Chlorzoxazone 20 95-25-0 API muscle relaxant

2277-92-
14 Oxyclozanide API Veterinary
1
15307-
15 Diclofenac sodium API NSAID
86-5

16 Metformin 657-24-9 API Antidiabetic

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 Page 3 of 43

17 Niclosamide (vet.) 50-65-7 API Veterinary

Chlorpheniramine
18 113-92-8 API antihistamine
maleate
26159-
19 Naproxen sodium API NSAID
34-2

20 Phenyl butazone 50-33-9 API NSAID

4,6-Dichloro-2- platelet
145783-
21 (propylthio)pyrimidine- Intermediates aggregation
15-9
5- amine inhibitor
114772-
22 BROMO-OTBN Intermediates Anti-hypertensive
54-2
83857-
23 BCFI Intermediates Anti-hypertensive
96-9
124750-
24 TTBB Intermediates Anti-hypertensive
51-2
1-H IMIDAZOLE 144689-
25 Intermediates Anti-hypertensive
ESTER 93-0
2-NITRO-4-
54029-
26 THOICYNAO- Intermediates Anthelmintic
45-7
ANILINE
2-CHLORO TRITYL 42074-
27 Intermediates Anti-Fungal
CHLORIDE 68-0
L-VALINE METHYL 6306-52-
28 Intermediates Anti-hypertensive
ESTER .HCL 1
Bis(2-
29 chloroethyl)amine 821-48-7 Intermediates antidepressant
hydrochloride 40
2-(Diethylamino)ethyl
30 Chloride 869-24-9 Intermediates antiarrhythmic
Hydrochloride
2-
4584-46-
31 (Dimethylamino)ethyl Intermediates antihistamine
7
chloride hydrochloride
3- Anti-
5407-04-
32 (Dimethylamino)propyl Intermediates depressant/Anti -
5
chloride hydrochloride angity
4-(Aminomethyl) hereditary
33 56-91-7 Intermediates
Benzoic Acid angioedema
5-Difluoromethoxy-2-
{[(3,4- dimethoxy-2- 102625- Proton Pump
34 Intermediates
pyridinyl)methyl]thio}- 64-9 Inhibitor(PPI)
1Hbenzimidazole
2-Chloromethyl 3,4-
Dimethoxy Pyridine 72830-
35 Intermediates PPI
HCl 09-2

2-Chloromethoxy-4-
153259-
36 (3-Methoxy Propoxy)- Intermediates PPI
31-5
3-Methyl Pyridine

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2-[[[4-(3-Methoxy
Propoxy)-3- Methyl
117977-
37 Pyridine-2-yl] Methyl] Intermediates PPI
21-6
Thio]-1H-
Benzimidazole
1131-01-
38 Chloro acetyl Xylidine Intermediates local anesthetic
7
METHYL
39 93-60-7 Intermediates antihistamine
NICOTINATE
68
Total
MT/Month

40 R& D Product 0.5

68.5
Total
MT/Month

# Brief Note of Product Profile:

1. No of Manufacturing Plants: 1 no
2. Brief Note regarding number of Products to be manufactured considering plant
capacity:
Total 11 no of reactors are required to manufacture proposed Products
We have calculated number of batch and number of stage for each product as per
the Batch size.
Considering 25 working days.
The project falls under Category B2 of project activity 5(f) as per the schedule of EIA
Notification 2006.
[Give specific end-use of each product. Ensure that proposed product profile is in line with
MoEF&CC’s Notification vide S.O. 1223 (E) dated 27/03/2020 in respect of Active
Pharmaceutical Ingredients (API) as category B2 projects. Undertaking as proposal of said
product are eligible to consider under B2 category as per the notification of MoEF&CC dated
27.03.2020.]
In case of Intermediate
Type/
stage of API
Category Said API is
Sr CAS Sta Name of API
of used
. Name of the No. ge in which
Product CAS for/End
N Product (Produ i.e. Intermediate
(API/ No. Use of said
o. ct) n-1, Used/ End
Intermedi (API) API
n-2, use of said
ate)
etc. Intermediate
Anti-
144689 - - -
1 Olmesartan API hypertensiv
-63-4
e
to treat
22457- - - -
2 Benfotiamine API diabetic
89-2
neuropathy.

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 Page 5 of 43

86386- - - -
3 Fluconazole API Anti -Fungal
73-4
117976 - - -
4 Rabeprazole API PPI
-89-3
102625 - - -
5 Pantoprazole API PPI
-70-7
Anti-
Losartan 124750 - - -
6 API hypertensiv
potassium -99-8
e
84625-
7 Itraconazole API - - - Anti-Fungal
61-6
to treat
148553
8 Pregabalin API - - - neuropathic
-50-8
pain
102767 Anti-
9 Levetriacetam API - - -
-28-2 epileptic
Anti-
10 Valproic acid 99-66-1 API - - -
epileptic
23593-
11 Clotrimazole API - - - Anti-Fungal
75-1
54965-
12 Albandazole API - - - anthelmintic
21-8
muscle
13 Chlorzoxazone 95-25-0 API - - -
relaxant
2277-
14 Oxyclozanide API - - - Veterinary
92-1
Diclofenac 15307-
15 API - - - NSAID
sodium 86-5
657-24-
16 Metformin API - - - Antidiabetic
9
Niclosamide
17 50-65-7 API - - - Veterinary
(vet.)
Chlorpheniramin 113-92- antihistamin
18 API - - -
e maleate 8 e
26159-
19 Naproxen sodium API - - - NSAID
34-2

20 Phenyl butazone 50-33-9 API - - - NSAID

4,6-Dichloro-2- 27469 platelet
145783 Intermedia TICAGRELO
21 (propylthio)pyrimi N-3 3-27- aggregation
-15-9 tes R
dine-5- amine 5 inhibitor
12475 Anti-
114772 Intermedia
22 BROMO-OTBN N-1 LOSARTAN 0-99- hypertensiv
-54-2 tes
8 e
12475 Anti-
83857- Intermedia
23 BCFI N-3 LOSARTAN 0-99- hypertensiv
96-9 tes
8 e
14468 Anti-
124750 Intermedia OLMESART
24 TTBB N-3 9-63- hypertensiv
-51-2 tes AN
4 e

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14468 Anti-
1-H IMIDAZOLE 144689 Intermedia KS OLMESART
25 9-63- hypertensiv
ESTER -93-0 tes M AN
4 e
2-NITRO-4-
54029- Intermedia KS ALBENDAZO 54965
26 THOICYNAO- Anthelmintic
45-7 tes M LE -21-8
ANILINE
2-CHLORO
42074- Intermedia KS CLOTRIMAZ 23593
27 TRITYL Anti-Fungal
68-0 tes M OLE -75-1
CHLORIDE
L-VALINE 13786 Anti-
6306- Intermedia
28 METHYL ESTER N-2 VALSARTAN 2-53- hypertensiv
52-1 tes
.HCL 4 e
Bis(2- 12972
821-48- Intermedia ARIPIPRAZO antidepress
29 chloroethyl)amin N-3 2-12-
7 tes LE ant
e hydrochloride 9
2-
(Diethylamino)eth 869-24- Intermedia KS AMIODARO 1951- antiarrhyth
30
yl Chloride 9 tes M NE 25-3 mic
Hydrochloride
2-
(Dimethylamino)e 4584- Intermedia KS Chlorphenam 132- antihistamin
31
thyl chloride 46-7 tes M ine 22-9 e
hydrochloride
3-
Anti-
(Dimethylamino)p 5407- Intermedia 549-
32 N-3 Amitriptyline depressant/
ropyl chloride 04-5 tes 18-8
Anti -angity
hydrochloride
hereditary
4-(Aminomethyl) Intermedia Tranexamic 1197-
33 56-91-7 N-2 angioedem
Benzoic Acid tes Acid 18-8
a
5-
Difluoromethoxy-
Proton
2-{[(3,4- 10262
102625 Intermedia Pump
34 dimethoxy-2- N-1 Pantoprazole 5-70-
-64-9 tes Inhibitor(PP
pyridinyl)methyl]t 7
I)
hio}-
1Hbenzimidazole
2-Chloromethyl
10262
3,4-Dimethoxy 72830- Intermedia
35 N-2 Pantoprazole 5-70- PPI
Pyridine HCl 09-2 tes
7
2-
Chloromethoxy- 11797
153259 Intermedia
36 4-(3-Methoxy N-3 Rabeprazole 6-89- PPI
-31-5 tes
Propoxy)-3- 3
Methyl Pyridine
2-[[[4-(3-Methoxy
Propoxy)-3-
11797
Methyl Pyridine- 117977 Intermedia
37 N-1 Rabeprazole 6-89- PPI
2-yl] Methyl] -21-6 tes
3
Thio]-1H-
Benzimidazole
Chloro acetyl 1131- Intermedia 137- local
38 N-2 Lidocaine
Xylidine 01-7 tes 58-6 anesthetic

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METHYL Intermedia KS 79794 antihistamin

39 93-60-7 Loratidine
NICOTINATE tes M -75-5 e

40 R& D Product - - - - - -

Brief summary regarding End-Uses of Product Profile:

1. Total No of API: 20
2. Total No of Intermediates (n-1):3
3. Total No of Intermediates (n-2): 4
4. Total No of Intermediates (n-3): 6
5. Total No of Intermediates (KSM): 6

4. Product wise Raw material consumption:

[Product wise raw material consumption in MT/MT of product per Month]

CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Group-A
Stage-I 2-Cyano-4-methyl biphenyl 114772-53-1 8.54

Stage-I Diisopropyl ether 108-20-3 21.20

Stage-I Dimethyl formamide 68-12-2 24.03

Stage-I Hydrochloric Acid 7647-01-0 12.8

Stage-I Hydrochloric Acid 7647-01-0 3.45

Stage-I Methylenedichloride 75-09-2 46.34

Stage-I Sodium hydroxide 1310-73-2 0.832

Stage-I Sodium azide 26628-22-8 6.408

Olmesartan
1
medoxomil Stage-I Triethyl amine 121-44-8 5.536

Stage-I Trityl chloride 76-83-5 12.27

Stage-I Zinc chloride 7646-85-7 12.8

Stage-
L-Tartaric acid diethyl ester 87-91-2 8
IIA

Stage-
Bromo-Dimethyl hydantoin 77-48-5 23.84
IIA

Stage-
Butanal 123-72-8 4.19
IIA

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-
Ammonium acetate 631-61-8 23.9
IIA

Stage-
Acetic acid 64-19-7 64
IIA

Stage-
Azo bis isobutyronitrile 78-67-1 0.12
IIA

Stage-
Toluene 108-88-3 80
IIA

Stage-
1,2-Dimethoxyethane 110-71-4 40
IIA

Stage-
Sodium hydroxide 1310-73-2 25.6
IIA

Stage-
Ammonium carbonate 8000-73-5 24
IIA

Stage-
Hydrochloric Acid 7647-01-0 48
IIA

Stage-
Sodium chloride 7440-23-5 24
IIA

Stage-
Isopropyl alcohol 67-63-0 40
IIA

Stage-
Tetrahydrofuran 109-99-9 48
IIB

Stage-
Methylmagnesium bromide 75-16-1 12.30
IIB

Stage-
Tetrahydrofuran 109-99-9 22.08
IIB

Stage-
Hydrochloric Acid 7647-01-0 12.8
IIB

Stage-
Toluene 108-88-3 24
IIB

Stage-
Sodium chloride 7440-23-5 8
IIB

Stage-
Toluene 108-88-3 103.09
III

Stage- Sodium hydroxide 1310-73-2 7.16

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
III

Stage-
Hyflo 68855-54-9 0.10
III

Stage-
Methanol 67-56-1 5.04
III

Stage-
Methylenedichloride 75-09-2 57.11
III

Stage-
Sodium bicarbonate 144-55-8 0.13
III

Stage-
N-Bromo succinamide 128-08-5 6.76
III

Stage-
Sodium bisulphite 7631-90-5 1.12
III

Stage- Tetra butyl Ammonium

1643-19-2 0.36
III Bromide

Stage-
Azo bis isobutyronitrile 78-67-1 0.32
III

Stage- 4-(chloromethyl)-5-methyl-
80841-78-7 5.296
IV 1,3-dioxol-2-one

Stage-
Sodium carbonate 497-19-8 0.8
IV

Stage- Tetra butyl Ammonium

1643-19-2 0.8
IV Bromide

Stage-
Ethyl acetate 141-78-6 48
IV

Stage-V Acetone 67-64-1 67.2

Stage-V Hydrochloric Acid 7647-01-0 1.32

Stage-V Activated Carbon 7440-44-0 2.4

Stage-V Ethyl acetate 141-78-6 48

Stage-I Thiamine hydrochloride 67-03-8 6.21

Stage-I Phosphorus Acid 7664-38-2 4.35

2 Benfotiamine
Stage-I Tributyl Amine 102-82-9 7.94

Stage-I Chloroform 67-66-3 13.80

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Thiamine monophosphate
Stage-II 273724-21-3 7.59
chloride

Stage-II Benzoyl Chloride 98-88-4 1.24

Stage-II Sodium hydroxide 1310-73-2 2.42

Stage-II Hydrochloric Acid 7647-01-0 0.69

1-[2-(2,4-Difluoro-phenyl) oxiranyl
1342260-26-7 6.2
methyl]-1H-[1,2,4]triazole

1,2,4-Triazole 288-88-0 3.616

Potassium carbonate 584-08-7 10.4

3 Fluconazole
Acetone 67-64-1 50.4

Ethyl acetate 141-78-6 62

Activated carbon 7440-44-0 0.8

2-{[4-(3-Methoxypropoxy)-3-
methyl pyridine-2-
Stage-I 117977-21-6 11.76
yl]methylthio}-1H-
benzimidazole

Stage-I Acetonitrile 75-05-8 28

Stage-I Sodium hydroxide 1310-73-2 3.536

12.5% Sodium Hypochlorite

Stage-I 7681-52-9 22.4
solution

Stage-I Sodium thiosulfate 7772-98-7 4.72

4 Rabeprazole Sodium
Stage-I Acetic acid use 64-19-7 7.08

Stage-I Ethyl acetate 141-78-6 93.6

Stage-II Sodium hydroxide 1310-73-2 0.93

Stage-II Methanol 67-56-1 12.68

Stage-II n-Buthyl Alcohol 71-36-3 3.24

Methyl Tert Butyl Ether

Stage-II 1173021-74-3 71.04
(MTBE)

Stage-I Maltol 118-71-8 6.8

5
Pantoprazole Sodium
Stage-I Potassium carbonate 584-08-7 4.4

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-I Acetone 67-64-1 26

Stage-I Dimethyl sulphate 77-78-1 3.6

Stage-II Ammonium Carbonate 8000-73-5 5.2

Stage-II Toluene 108-88-3 41.2

Stage- 2.8
Phosphorous oxychloride 10025-87-3
III

Stage- 0.8
Sodium hydroxide 1310-73-2
III

Stage- 28.8
Ethylene dichloride 107-06-2
III

Stage- 3.2
Hydrogen peroxide (30%) 7722-84-1
IV

Stage- 32
n-Hexane 110-54-3
IV

Stage- 35.2
Methylenedichloride 75-09-2
IV

Stage- 3.2
Acetic acid use 64-19-7
IV

Stage- 1.76
Sodium hydroxide 1310-73-2
IV

Stage-V Sodium Methoxide 124-41-4 1.84

Stage-V Methanol 67-56-1 14.4

Stage-
Acetic Anhydride 108-24-7 3.2
VI

Stage- 1.2
Sodium hydroxide 1310-73-2
VII

Stage- 22
Methylenedichloride 75-09-2
VII

Stage- 3.12
Thionyl chloride 7719-09-7
VIII

Stage- 28
Toluene 108-88-3
VIII

Acetone 67-64-1 10.4

Stage-

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
VIII

Stage- 5-diFluoromethoxy-2- 5.6

97963-62-7
IX mercapto- benzimidazole

Stage- 2
Sodium hydroxide 1310-73-2
IX

Stage- 19.2
Toluene 108-88-3
IX

Stage-X Sodium Hypochloride 7681-52-9 1.6

Stage-X Activated Carbon 7440-44-0 0.8

Stage-I 2-Cyano-4-methyl biphenyl 114772-53-1 8.544

Stage-I Diisopropyl ether 108-20-3 21.208

Stage-I Dimethyl formamide 68-12-2 24.032

Stage-I Hydrochloric Acid 7647-01-0 12.8

Stage-I Hydrochloric Acid 7647-01-0 3.4512

Stage-I Methylenedichloride 75-09-2 46.344

Stage-I Sodium hydroxide 1310-73-2 0.832

Stage-I Sodium azide 26628-22-8 6.408

Stage-I Triethyl amine 121-44-8 5.536

6 Losartan potassium
Stage-I Trityl chloride 76-83-5 12.272

Stage-I Zinc chloride 7646-85-7 12.816

Stage-II Valeronitrile 110-59-8 5.104

Stage-II Acetic acid use 64-19-7 4.888

Stage-II Activated carbon 7440-44-0 0.384

Stage-II Sodium hydroxide 1310-73-2 10.88

Stage-II Dimethyl formamide 68-12-2 7.368

Stage-II Disodium EDTA 6381-92-6 0.04

Stage-II Glycine 56-40-6 4.344

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-II Hydrochloric Acid 7647-01-0 4.592

Stage-II Hyflo 68855-54-9 0.048

Stage-II Methanol 67-56-1 12.344

Stage-II Sodium hydroxide 1310-73-2 31.352

Stage-II Phosphorous oxychloride 10025-87-3 27.168

Stage-II Sodium meta bisulphate 7681-57-4 5.04

Stage-II Toluene 108-88-3 33.32

Stage-
Azo bis isobutyronitrile 78-67-1 0.32
III

Stage-
Sodium hydroxide 1310-73-2 7.16
III

Stage-
HyFlo 68855-54-9 0.104
III

Stage- 5.048
Methanol 67-56-1
III

Stage- 60
Methylenedichloride 75-09-2
III

Stage- 2.008
Sodium borohydride 16940-66-2
III

Stage- 0.136
Sodium bicarbonate 144-55-8
III

Stage- 6.76
N-Bromo succinamide 128-08-5
III

Stage- 1.128
Sodium bisulphite 7631-90-5
III

Stage- Tetra butyl Ammonium 0.368

1643-19-2
III Bromide

Stage- 40.112
Toluene 108-88-3
III

Stage- 39.128
Acetonitrile 75-05-8
IV

Stage-
Cyclohexane 110-82-7 39.12
IV

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-
Isopropyl alcohol 67-63-0 44.49
IV

Stage-
Potassium hydroxide 1310-58-3 2.27
IV

Stage-
Sodium hydroxide 1310-73-2 7.23
IV

Stage-
Sulfuric acid 7664-93-9 4.25
IV

4-(4-(4-
Stage-I methoxyphenyl)piperazin-1- 74852-62-3 6.8
yl)aniline

Stage-I Phenyl Chloro formate 1885-14-9 3.76

Stage-I Methylenedichloride 75-09-2 43.2

Stage-I Sodium bicarbonate 144-55-8 2.016

Stage-II Hydrazine Hydrate 7803-57-8 1.08

Stage-II 1,4-Dioxane 123-91-1 42

Stage-
Formamidine 3473-63-0 0.84
III

Stage-
Dimethyl formamide 68-12-2 19.2
III
7 ITRACONAZOLE Stage-
Acetic Acid 64-19-7 2.28
III

Stage-
Dimethyl formamide 68-12-2 24
IV

Stage-
2-Bromo Butane 78-76-2 2.36
IV

Stage- 16
Methanol 67-56-1
IV

Stage-
Potassium Carbonate 584-08-7 1.176
IV

Stage-V Hydrogen Bromide 10035-10-6 2.4

Stage-V Methanol 67-56-1 32

Stage-V Sodium Carbonate 497-19-8 1.56

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-
Cis-Bromo Benzoate 61397-56-6 7.2
VI

Stage-
Dimethyl formamide 68-12-2 14.4
VI

Stage-
1,2,4-Triazole 288-88-0 1.12
VI

Stage-
Sodium hydroxide 1310-73-2 0.68
VI

Stage-
Potassium Carbonate 584-08-7 1.12
VI

Stage-
Methylenedichloride 75-09-2 48
VII

Stage-
Isopropyl alcohol 67-63-0 48
VII

Stage-
Methane Sulfonyl Chloride 124-63-0 1.68
VII

Stage-
Triethyl amine 121-44-8 1.52
VII

Stage-
Dimethyl formamide 68-12-2 80
VIII

Stage-
Methanol 67-56-1 80
VIII

Stage-
Potassium Hydroxide 1310-58-3 0.8
VIII

Stage-
Activated Carbon 7440-44-0 0.64
VIII

3- (Amino methyl)-5-methyl hexanoic

30912-52-6 8.42
acid

Mandelic acid 611-71-2 10.97

Ammonia 7664-41-7 1.24

8 Pregabalin
Citric Acid Monohydrate 5949-29-1 6.34

Methanol 67-56-1 124.44

Activated Carbon 7440-44-0 0.68

9 Levetiracetam SABMA 7682-20-4 6.8

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
4-Chlorobutyryl chloride 4635-59-0 7.36

Potassium hydroxide 1310-58-3 5.6

Tetra butyl Ammonium Bromide 1643-19-2 0.08

Methylenedichloride 75-09-2 48

Ethyl acetate 141-78-6 8

Group B
10 Valproic Acid Dipropyl malonic acid 1636-27-7 40

(chloro(2chlorophenyl) 26.7
methylene)dibenzene 42074-68-0

Imidazole 6
288-32-4
Toluene 26.7
108-88-3
11 Clotrimazole
Triethyl amine 9.34
121-44-8
Acetone 30
67-64-1
Activated carbon 7440-44-0 0.7

4-propylthio-o-phenylene diamine 66608-52-4 18.70

Methanol 67-56-1 14.5

12 Albendazole
Ammonium salt of cyano Carbamate 1111-78-0 9.80

Acetic acid use 64-19-7 9.57

Stage-I 4 Chloro 2 Amino Phenol 95-85-2 20

Stage-I Urea 57-13-6 25

Stage-I Hydrochloric Acid 7647-01-0 30.8

Stage-I Sodium Hydro Sulphite 7775-14-6 0.2

Stage-II Caustic soda lye 1310-73-2 10.8

13 Chlorzoxazone
Stage-II Hydrochloric Acid 7647-01-0 16

Stage-II Activated Carbon 7440-44-0 0.8

Stage-II Sodium Hydro Sulphide 16721-80-5 0.4

Stage-
Methanol 67-56-1 28
III

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-
Activated Carbon 7440-44-0 0.6
III

Stage-
Sodium Hydro Sulphide 16721-80-5 0.2
III

2,3,5-6-hydroxy benzoic acid 2215-21-6 12.28

Thionyl chloride 7719-09-7 6.06

14 Oxyclozanide
2-amino-4,6-dichloro phenol 527-62-8 9.06

Mono Chloro benzene 108-90-7 82

Stage-I 2,6-dichloro diphenyl amine 15307-93-4 14.95

Stage-I Toluene 108-88-3 12.88

Stage-I Chloro acetyl chloride 79-04-9 10.35

N-Chloro acetyl 2,6-dichloro

Stage-II 15308-01-7 18.4
diphenyl amine

Stage-II Aluminium chloride 7446-70-0 12.88

15 Diclofenac Sodium Stage-

Indolenone 15362-40-0 18.17
III

Stage-
Sodium hydroxide 1310-73-2 4.715
III

Stage-
Activated Carbon 7440-44-0 0.368
IV

Stage-
Hyflow 68855-54-9 0.23
IV

Dicyano diamide 461-58-5 12.6

Xylene 1330-20-7 50.4

Dimethyl amine HCl 506-59-2 14.74

16 Metformin HCl
Methanol 67-56-1 25.2

Activated Carbon 7440-44-0 0.315

Hyflow 68855-54-9 0.63

Stage-I 5-chloro salicylic acid 321-14-2 12.5

17 Niclosamide
Otho Chloro Para Nitro 13
Stage-I 121-87-9
Aniline

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-I Phosphorous trichloride 7719-12-2 14

Stage-I Toluene 108-88-3 50

Stage-I Methanol 67-56-1 20

Stage-II Methanol 67-56-1 20

Stage-II Activated Carbon 7440-44-0 0.42

Stage-II Hyflow 68855-54-9 0.75

Stage-I 4-Chloro benzyl cyanide 140-53-4 8.55

Stage-I P-chloro pyridine 7379-35-3 3.6

Dimethyl amino ethyl

Stage-I 4584-46-7 6.3
18 Chlorpheniramine chloride
Maleate
Stage-II Chlorpheniramine base 113-92-8 14.85

Stage-II Maleic acid 110-16-7 7.92

Stage-II Isopropyl alcohol 67-63-0 29.7

1-(6-Methoxynaphthalen-2-yl)
Stage-I 3900-45-6 20.64
ethanone

Stage-I hydroxylamine hydrochloride 5470-11-1 7.74

Stage-I Sodium hydroxide 1310-73-2 8.6

Stage-I Potassium butan-2-olate 41233-93-6 11.18

19 Naproxen sodium (E)-2-(6-methoxy naphtha

Stage-II 27602-76-2 21.5
len-2-yl) propanal oxime

Stage-II Potassium hydroxide 1310-58-3 4.73

Stage-II 2-Butanol 78-92-2 11.61

Stage-II Ammonia 7664-41-7 13.54

Stage-II Hydrochloric Acid 7647-01-0 4.73

Stage-I N-Butyl diethyl malonate 133-08-4 19.58

Stage-I Hydrzobenzene 122-66-7 15.62

20 Phenyl Butazone
Stage-I Sodium Methoxide 124-41-4 5.28

Stage-I Sodium Hydro Sulphide 16721-80-5 0.44

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-I Toluene 108-88-3 19.58

Stage-I Acetic acid 64-19-7 15.62

Stage-II Methanol 67-56-1 88

Stage-II Activated Carbon 7440-44-0 0.44

Stage-II Hyflow 68855-54-9 0.33

Group-C
5-amino-2-(propylthio) pyrimidine-4,6-
145783-13-7 40
4,6-dichloro-2- diol
21 (propylthio)pyrimidine-
Thionyl chloride 7719-09-7 50
5-amine
Ethyl acetate 141-78-6 120

4'-Methyl-2-cyanobiphenyl 31.96
114772-53-1
22 Bromo OTBN Methylenedichloride 223.60
75-09-2
Bromine 26.44
7726-95-6
Valeronitrile 32.89
110-59-8
Acetic acid use 64-19-7 31.50

Activated Carbon 2.47

7440-44-0
Caustic soda lye 70.10
1310-73-2
Dimethyl formamide 47.47
68-12-2
Disodium EDTA 0.26
6381-92-6
Glycine 27.99
56-40-6
23 BCFI
Hydrochloric Acid 29.59
7647-01-0
Hyflo 0.31
68855-54-9
Methanol 46.39
67-56-1
Sodium hydroxide 202.01
1310-73-2
Phosphorous oxychloride 175.05
10025-87-3
Sodium metabisulphite 32.47
7681-57-4
Toluene 266.24
108-88-3

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-I OTBN 114772-53-1 20.5

Stage-I Zinc chloride 7646-85-7 41

Stage-I Sodium Azide 26628-22-8 10.25

Stage-I Dimethyl formamide 68-12-2 82

Stage-I Hydrochloric Acid 7647-01-0 20.5

Stage-II Ethylene dichloride 107-06-2 24.6

24 TTBB
Stage-II Trityl chloride 76-83-5 246

Stage-II Methanol 67-56-1 29.93

Stage- 215.25
Methylenedichloride 75-09-2
III

Stage- Di bromo di methyl 15.99

77-48-5
III hydantoin

Stage- 71.545
Ethyl acetate 141-78-6
III

diethyl 2-propyl-1H-imidazole -4,5-

129165-76-0 44.5
dicarboxylate

Methyl magnesium chloride 676-58-4 48.95

Ethyl-4-(1-hydroxy-1-
methylethyl)-2- Tetrahydrofuran 178
25 109-99-9
propylimidazole-5-
carboxylate Ammonium chloride 12125-02-9 133.5

Ethyl acetate 141-78-6 133.5

Diisopropyl ether 108-20-3 89

2-Nitro Aniline 88-74-4 28.8

2-Nitro-4- Ammonium thiocyanate 1762-95-4 32.56

26
thiocyanoaniline Methanol 60
67-56-1
Chlorine gas 7782-50-5 14.8

Ortho- Chlorobenzotrichloride 2136-89-2 40.25

27 2-Chlorotrityl Chloride Benzene 71-43-2 312.225

Aluminium Chloride 7446-70-0 44.275

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Hydrochloric Acid 7647-01-0 80.5

Sodium Chloride 7440-23-5 24.15

Toluene 108-88-3 16.1

n-Hexane 110-54-3 158.125

L-Valine 72-18-4 28.8

Methanol 67-56-1 128

L-Valine methyl ester
28 Thionyl chloride 7719-09-7 22.4
hydrochloride
Sodium hydroxide 1310-73-2 22.4

Methylenedichloride 75-09-2 96

Diethanol amine 111-42-2 25

Bis(2- Thionyl chloride 55

7719-09-7
29 chloroethyl)amine
Hydrochloride Chloroform 67-66-3 25

IPA HCl ‎6638-79-5 34

Diethyl amino ethanol 100-37-8 41.652

2-(Diethylamino)ethyl
30 Chloride Thionyl chloride 7719-09-7 28.836
Hydrochloride
Ethylene dichloride 107-06-2 89

Dimethyl amino ethanol 108-01-0 37.5

2-
31 (Dimethylamino)ethyl Thionyl chloride 7719-09-7 32.5
chloride hydrochloride
Ethylene dichloride 107-06-2 50

Dimethyl amino propanol 108-16-7 33.5

3-(Dimethyl amino)
32 propyl chloride Thionyl chloride 7719-09-7 42.21
hydrochloride
Ethylene dichloride 107-06-2 80.4

Stage-I Para toluic acid 99-94-5 20.5242

Stage-I N-Bromo succinamide 128-08-5 26.8284

4-(Aminomethyl)
33 Stage-I Mono Chloro benzene 108-90-7 71.1
Benzoic Acid
Stage-II Potassium phthalamide 1074-82-4 27.9186

Stage-II Ethanol 64-17-5 35.55

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-I Maltol 118-71-8 34

Stage-I Potassium carbonate 584-08-7 22

Stage-I Acetone 67-64-1 130

Stage-I Dimethyl sulphate 77-78-1 18

Stage-II Ammonium Carbonate 8000-73-5 26

Stage-II Toluene 108-88-3 86

Stage- 14
Phosphorous oxychloride 10025-87-3
III

Stage- 4
Sodium hydroxide 1310-73-2
III

Stage- 144
Ethylene dichloride 107-06-2
III

Stage- 16
Hydrogen peroxide (30%) 7722-84-1
IV
5-Difluoromethoxy-2-
{[(3,4- dimethoxy-2- Stage- 160
34 n-Hexane 110-54-3
pyridinyl)methyl]thio}- IV
1Hbenzimidazole
Stage- 176
Methylenedichloride 75-09-2
IV

Stage- 16
Acetic acid use 64-19-7
IV

Stage- 8.8
Sodium hydroxide 1310-73-2
IV

Stage-V Sodium Methoxide 124-41-4 9.2

Stage-V Methanol 67-56-1 72

Stage-
Acetic Anhydride use 108-24-7 16
VI

Stage-
Sodium hydroxide 1310-73-2 6
VII

Stage-
Methylenedichloride 75-09-2 110
VII

Stage-
Thionyl chloride 7719-09-7 15.6
VIII

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-
Toluene 108-88-3 76
VIII

Stage-
Acetone 67-64-1 52
VIII

Stage- 5-diFluoromethoxy-2- 28
97963-62-7
IX mercapto- benzimidazole

Stage- 10
Sodium hydroxide 1310-73-2
IX

Stage- 74
Toluene 108-88-3
IX

Stage-I Maltol 118-71-8 52.36

Stage-I Potassium carbonate 584-08-7 33.88

Stage-I Acetone 67-64-1 187.88

Stage-I Dimethyl sulphate 77-78-1 27.72

Stage-II Ammonium Carbonate 8000-73-5 40.04

Stage-II Toluene 108-88-3 132.44

Stage- 21.56
Phosphorous oxychloride 10025-87-3
III

Stage- 6.16
Sodium hydroxide 1310-73-2
III
2-Chloromethyl 3,4-
35 Dimethoxy Pyridine Stage-
HCl Ethylene dichloride 107-06-2 221.76
III

Stage- 24.64
Hydrogen peroxide (30%) 7722-84-1
IV

Stage- 246.4
n-Hexane 110-54-3
IV

Stage- 135.52
Methylenedichloride 75-09-2
IV

Stage- 24.64
Acetic acid use 64-19-7
IV

Stage- 13.552
Sodium hydroxide 1310-73-2
IV

Stage-V Sodium Methoxide 124-41-4 14.168

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-V Methanol 67-56-1 110.88

Stage-
Acetic Anhydride 108-24-7 24.64
VI

Stage- 9.24
Sodium hydroxide 1310-73-2
VII

Stage- 107.8
Methylenedichloride 75-09-2
VII

Stage-
Thionyl chloride 7719-09-7 24.024
VIII

Stage-
Toluene 108-88-3 129.36
VIII

Stage-
Acetone 67-64-1 80.08
VIII

4-Chloro-2,3-dimethyl pyridine-N-oxide
59886-90-7 40.08
hydrochloride

3-methoxy propanol 1589-49-7 21.71

2-chloromethyl-4-(3-
methoxy propoxy)-3- Methylenedichloride 167
36 75-09-2
methylpyridine
hydrochloride Sodium hydroxide 1310-73-2 33.4

Tetra butyl Ammonium Bromide 1643-19-2 1.002

Hydrochloric Acid 7647-01-0 16.7

4-Chloro-2,3-dimethyl
Stage-I pyridine-N-oxide 59886-90-7 34.32
hydrochloride

Stage-I 3-methoxy propanol 1589-49-7 18.59

Stage-I Methylenedichloride 75-09-2 143

2-[[(4-(3-
methoxypropoxy)-3- Stage-I Sodium hydroxide 1310-73-2 28.6
37 methyl- 2-pyridinyl) Tetra butyl Ammonium
methyl] thio]-1H- Stage-I 1643-19-2 0.858
Bromide
benzimidazole
Stage-I Hydrochloric Acid 7647-01-0 14.3

2-hydroxymethyl-4-(3-
Stage-II methoxy propoxy)-3-methyl 118175-10-3 34.32
pyridine hydrochloride

Stage-II Toluene 108-88-3 97.24

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CAS / CI no. Quantity

Sr.
Name of Product Name of Raw Material of raw
No. MT/Month
materials
Stage-II Thionyl chloride 7719-09-7 16.445

2-chloromethyl-4-(3-methoxy
Stage-
propoxy)-3-methylpyridine 153259-31-5 35.75
III
hydrochloride

Stage- 2-mercapto-1H-benzo [d]

58089-25-1 22.022
III imidazol-6-ylium

Chloro acetyl chloride 79-04-9 23.75

2,6- Xylidine 87-62-7 23.75

38 Chloro acetyl Xylidine
Caustic soda lye 1310-73-2 0.75

Toluene 108-88-3 47.5

Nicotinic acid 59-67-6 40

Methanol 67-56-1 100

39 Methyl Nicotinate Sulfuric acid 7664-93-9 0.8

Chloroform 67-66-3 60

Sodium bicarbonate 144-55-8 40

5. Salient features of the project including Water, Air and Hazardous waste
management:
Sr. no. Particulars Details
A-1 Total cost of Proposed Project
(Rs. in Crores):
Total Project
6 Crores
Break-up of proposed project Cost:
Details Project Cost (Rs. In Crores)
Land Rent
Building 1.5
Machinery 3.05
EMP cost 1.45
A-2 Details of Environmental Management Plan As below:
(EMP)

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Total
Capital Operating
Maintenance Recurring
Sr. Cost Cost (Rs.
Unit Detail Cost (Rs. In Cost
No (Rs. In In
Crores) (Rs. In
(Crores) Crores)
Crores)
Capital cost would
include cost of septic
tank/soak pit system,
ETP & MEE/ ATFD
1 Waste Water etc. and recurring cost 0.888 0.8748 0.03336 0.90816
would include
maintenance charges,
manpower salary, &
treatment cost etc.
Capital cost would
include air pollution
control devices and
the recurring cost
would include
2 Air operation and 0.369 0.040 0.010 0.050
maintenance of
chimney and air
pollution control
system, manpower
salary
Capital cost would
include expense for
providing storage area
for hazardous waste
and membership
Hazardous charge of TSDF & 0.015 7.404 0.000 7.4038
3
Management CHWIF site and
recurring cost would
be for solid/
hazardous waste
packing & its disposal
to TSDF/CHWIF site.
Capital cost would
include cost of OHS
center, fire hydrant 0.112 0.003 0.000 0.0025
4 Fire & Safety
system and recurring
cost would include
maintenance charges
Stack emission
AWH monitoring, Water 0.000 0.07713 0 0.07713
5
Monitoring sample analysis
charges

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Capital cost would

include development
of green belt within
and outside the
Green Belt 0.005 0.013 0.000 0.0125
6. project premises and
Development
recurring cost would
include maintenance
charges, manpower
salary etc
Occupational 0.026 0.008 0.000 0.0080
7. PPEs
Health
Capital cost would
include providing
adequate sound
8. Noise enclosures and 0.009 0.004 0.000 0.0036
recurring cost would
include monitoring of
noise level.
Miscellaneous activity
such as development
of rain water
harvesting system,
and recurring cost 0.025 0.200 0.000 0.200
9. Miscellaneous
would include
regulatory
compliances and
hiring of EHS
manager
Total 1.45 8.62 0.043 8.6

Summary
Cost of Project in Crores per Annum: 6
EMP Capital Cost in Crores per Annum and Percentage: 1.45 & 24.16 %
EMP Recurring Cost in Crores per Annum and Percentage: 8.6
A-3 Details of CER as per OM dated 01/05/2018 (In case of project
falls under CPA/SPA, CER fund allocation to be at least 1.5 times
the slabs given in the OM dated 01.05.2018 for SPA and 2 times
for CPA in case of Environmental Clearance as per the mechanism
published vide MoEF&CC’s OM vide 31.10.2019.)
% as per the OM Rs. in Crores
2 0.12
Brief note on proposed activities:

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Year (Amount to be Total amount

Sr. spent in Lakhs)
Activity to be spent in
No.
1st 2nd 3rd Lakhs

Safe Drinking Water Facilities

Ro facility (200 liter per hour)
including annual maintenance
contract for drinking water in Hirasar
1 Primary school (Jalida) (1st year) and 1.2 1.2 1 3.4
Rampar Beti Primary school (2nd
year) and maintenance of the RO
facility in the (3rd year).
Infrastructure development & Healthcare Facilities
Paver block facility in nearest school
Hirasar Primary school (1st year) &
2 Equipment's for sanitation facility (Up 2 1 0 3
gradation of Toilets and Water Tank
in School) (2nd year)
Renewable energy
Solar street light (12 W) in Hirasar
(1st year, 15 Units), Bamanbore
3 village (2nd year, 15 Units) and 2 2 1.6 5.6
Rampar Beti village (3rd year, 12
Units)
Total 5.2 4.2 2.6 12

B Land / Plot ownership details:

Land has been purchased.
B-1 Plot area
Total Plot area
3634.9 Sq. m.
B-2 Brief note on Area adequacy in line to proposed project activities:
Proposed API plant area 2419.4 m2 which is enough to produced
proposed products.
B-3 Green belt area
Total (Sq. meter)
Area in Sq. meter 1199.5
% of total area 33 %

C Employment generation
Total
13

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D WATER
D-1 Source of Water Supply
(GIDC, Bore well, Surface water, Tanker supply etc...)
GIDC Supply
Status of permission from the concern authority.
 Not Applicable our water supply met through GIDC supply
D-2 Water consumption (KLD)

Category Quantity KLD Remarks

(A) Domestic 1.4
(B) Gardening 3.60
(C) Industrial
RO1 49.48
Process 36.59 Ro permeate will be used in
process
Boiler 3 Ro permeate will be used in
boiler
Washing 1
Cooling 11.45
Scrubbing 5.04
Industrial Total 66.97
Total (A + B + C) 71.97
Brief Note on worst case scenario for water consumption:
Among all the product maximum water consumption is 19.26
KL/day for 2-Chloromethyl 3,4-Dimethoxy Pyridine HCl.

Summary of water Quantity Remarks

requirement KLD
Total water 71.97
requirement for the
project (A)
Quantity to be recycled 55.46
(B)
Total fresh water 16.51
requirement (C)
Ensure Total water requirement = Fresh water + Recycled
water
i.e. A = B + C
Reuse/Recycle details (KLD) with feasibility.
[Source of reuse & application area]

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Source of Application Characteristics of Remarks

waste area with waste water to be regarding
water for quantity in reused (COD, BOD, feasibility
reuse in KLD TDS etc.) to reuse
KLD (From (Where it is
where it is used)
coming)
RO Total 55.46 Ro RO
Particular
permeate KLD from Permeate permeate
RO will be Quantity 55.46 will be
used in pH 6.5-7.5 used in
industrial TDS <500 industrial
purpose COD <250 activities
such as TSS <10
washing,
process
and
scrubber.
D-3 Waste water generation (KLD)

Category Waste Remarks

water KLD
(A) Domestic 1.31 Will be treated STP
(B) Industrial
RO1 9.89
Process 54.09
Washing 1
Boiler 0.3
Cooling 1.14
Scrubbing 2.5
Total Industrial 68.92
waste water
Total [A + B] 70.23
Brief Note on worst case scenario for waste water generation (Qualitative and
Quantitative):
 In worst case scenario 26.73 KLD wastewater will be generated from the
manufacturing process of proposed products BCFI.
Brief justification in case of no process effluent generation or no industrial effluent
generation or no high concentration effluent generation from proposed project
(Whichever is applicable).
 Not applicable
D-4 Mode of Disposal & Final meeting point

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-
Domestic: 1.31 KL/day sewage will be generated from the domestic activities of the
proposed expansion project which will be treated in ETP along with the
dilute stream
Industrial: W/W generation from industrial activities will be 68.92 KLD.
 11.2 KLD W/W containing Ammonical Nitrogen will be treated in
ammonia stripper and 42.89 KLD high COD, stream containing washing
w/w of 1 KLD, scrubber w/w of 2.5 KLD along with the stream containing
Ammonical nitrogen will be treated in VOC stripper and then the w/w
from VOC stripper goes to MEE for further treatment.
 MEE condensate 56.72 KLD with w/w stream coming out from domestic
1.31 KLD, cooling tower blow down 1.14 KLD, RO-reject i.e. 9.89 KLD,
Boiler blow-down i.e. 0.3 KLD will be going to ETP.
 ETP will be consisting of collection cum neutralization tank, primary
clariflocculator, aeration tank, secondary clariflocculator, PSF & ACF
and RO-2.
 Sludge generated from ETP and MEE salt will be sent to TSDF site.
Hence, the unit will maintain the zero liquid discharge.
Clearly mention about final disposal
D-5 Treatment facilities
For Domestic waste water:
Total 1.31 KL/day sewage will be generated from the domestic activities of the proposed
expansion project which will be treated in ETP along with the dilute stream.
For Industrial waste water: Treatment facility within premises with capacity
[In-house ETP (Primary, Secondary, Tertiary), MEE, Stripper, Spray Dryer, STP etc.

ETP UNITS WITH CAPACITY :

Unit No. of units Size/
Capacity
For Ammonical Stream

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Collection tank - 1 20 KL 1
3
Ammonia stripper 0.5 m /Hr 1
For Concentrated Stream
Collection cum Neutralization Tank - 50 KL 2
2
VOC Stripper 2.5 m3/Hr 1
Holding Tank 50 KL 2
MEE 3 m3/Hr 1
For Dilute Stream
Collection Cum Neutralisation Tank- 40 KL 3
3
Primary Clarifloculator 40 KL 3
Aeration tank 40 KL 3
Secondary Clarifloculator 40 KL 3
Pressure sand filter 3 KL/Hr. 1
Activated carbon filter 3 KL/Hr. 1
RO 2 3 KL/Hr. 1

Treatment scheme including segregation at source. (Give Characteristics of each stream

i.e. COD, BOD, TDS etc.) In case of stream segregation, Separate ETP (ETP-1, ETP-
2….) for each stream shall be proposed.
INDUSTRIAL EFFLUENT TREATMENT SCHEME :
 W/W generation from industrial activities will be 68.92 KLD.
 11.2 KLD W/W containing Ammonical Nitrogen will be treated in ammonia stripper
and 42.89 KLD high COD, stream containing washing w/w of 1 KLD, scrubber w/w of
2.5 KLD along with the stream containing Ammonical nitrogen will be treated in VOC
stripper and then the w/w from VOC stripper goes to MEE for further treatment.
 MEE condensate 56.72 KLD with w/w stream coming out from domestic 1.31 KLD,
cooling tower blow down 1.14 KLD, RO-reject i.e. 9.89 KLD, Boiler blow-down i.e. 0.3
KLD will be going to ETP.
 ETP will be consisting of collection cum neutralization tank, primary clariflocculator,
aeration tank, secondary clariflocculator, PSF & ACF and RO-2.
 Sludge generated from ETP and MEE salt will be sent to TSDF site. Hence, the unit
will maintain the zero liquid discharge.
CHARACTERISITCS OF EACH STREAM :
Quanti
ty
w/w from pH TSS (mg/l) TDS (mg/l) COD (mg/l)
(kl/day
)
Low Low
High High Highe Highe
er er Lower Lower
er er r r
valu valu value value
value value value value
e e
Scrubber 2.5 6.5 7.5 20 30 1500 2000 100 200
High COD stream 42.9 3.4 4.5 200 250 40000 45000 50000 60000
After AMMONIA 10000
11.0 6.5 7.5 150 300 25000 45000 60000
stripper 0
washing 1.0 6.0 7.0 200 250 200 300 400 500
182. 34754 42348 48878 64025
Composite effluent 57.4 4.2 5.2 250.0
6 .3 .0 .7 .1

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Quanti
ty
w/w from pH TSS (mg/l) TDS (mg/l) COD (mg/l)
(kl/day
)
Low High Low High
Lowe Highe Lowe Highe
er er er er
r r r r
valu valu valu valu
value value value value
e e e e

after VOC
57.0 5.5 7.0 120 200 19100 30000 30000 40000
stripper
RO reject-2 13.9 6.5 7.5 20.0 30 5000 5150 10 20
Composite 100. 16335 25128 24120 32161
70.9 5.7 7.1 166.7
effluent 4 .7 .1 .4 .9

Quanti
ty
w/w from pH TSS (mg/l) TDS (mg/l) COD (mg/l)
(kl/day
)
Low Low Low Low
High High High Highe
er er er er
er er er r
valu valu valu valu
value value value value
e e e e
Cooling Tower
1.8 7.5 8.5 80 100 4000 5000 60 80
Blowdown
Boiler
0.28 7.5 8.5 40 50 4000 4500 60 80
Blowdown
Domestic 1.3 6.5 8.5 100 220 250 500 250 500
Ro1 reject 9.84 6.5 7.5 100 150 6000 7000 40 80
MEE 1000
56.7 6.5 7.5 10 20 1600 2900 16000
condensate 0
Composite 2265. 3492. 8117. 12991
69.98 6.5 7.5 26.3 44.2
effluent 8 9 3 .3
Note: (In case of CETP discharge) :
Management of waste water keeping in view direction under section 18 (1) (b) of the
Water (Prevention and Control of Pollution) act, 1974 issued by CPCB regarding
compliance of CETP.
 Not Applicable
Brief note on adequacy of ZLD (In case of Zero Liquid Discharge):
 W/W generation from industrial activities will be 68.92 KLD.
 11.2 KLD W/W containing Ammonical Nitrogen will be treated in ammonia stripper and
42.89 KLD high COD, stream containing washing w/w of 1 KLD, scrubber w/w of 2.5
KLD along with the stream containing Ammonical nitrogen will be treated in VOC
stripper and then the w/w from VOC stripper goes to MEE for further treatment.
 MEE condensate 56.72 KLD with w/w stream coming out from domestic 1.31 KLD,

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cooling tower blow down 1.14 KLD, RO-reject i.e. 9.89 KLD, Boiler blow-down i.e. 0.3
KLD will be going to ETP.
 ETP will be consisting of collection cum neutralization tank, primary clariflocculator,
aeration tank, secondary clariflocculator, PSF & ACF and RO-2.
 Sludge generated from ETP and MEE salt will be sent to TSDF site. Hence, the unit will
maintain the zero liquid discharge.
D-6 In case of Common facility (CF) i.e. CETP, Common Spray dryer,
Common MEE, CHWIF etc.
Name of Common facility (CF) (For waste water treatment)
 Not applicable as unit will maintain Zero Discharge
Membership of Common facility (CF) mentioning total capacity,
consented quantity, occupied capacity and spare capacity and
norms of acceptance of effluent from member unit’s in-line with the
direction given by GPCB vide Letter No. GPCB/P-1/8-G (5)/550706
dated 08/01/2020.
 Not applicable
D-7 Simplified water balance diagram with reuse / recycle of waste
water

E AIR
E-1 Brief Note on fuel based Heat energy requirement and worst
case scenario thereof:

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Bio Coal will be used for heat energy. The GCV of coal is 4000
kcal/hr

E-2 Flue gas emission details

No. of Boilers/TFH/Furnaces/DG sets etc. with capacities viz. TPH,
Kcal/hr, MT/hr, KVA etc.
(In case of Project located within CPA/SPA , APCM shall be in line
to the mechanism published in the MOEFCC’s OM vide dated
31.10.2019)
Source of Air Pollution Type of
Stack Quantity of
Sr. emission Type of Control emissions
Height Fuel
No. With Fuel Measures i.e. Air
(m) MT/Day
Capacity (APCM) Pollutants
Steam Multi Cyclone
SPM  150
Boiler Separator and
1 15 Bio coal 1 MT/day mg/Nm3
(1000 adequate
SO2  100
Kg/hr) stack height
ppm
D.G. set Diesel Adequate
2
(125 KVA)
10 9.1 L/Hr.
stack height NOx 50 ppm
E-3 Process gas i.e. Type of pollutant gases (SO2, HCl, NH3, Cl2, NOx
etc.)
-
Specific Source of Stack/Vent Air Pollution Control
Sr. Type of
emission (Name of the Height Measures
No. emission
Product & Process) (meter) (APCM)
Dual condenser system
Process Reactor
on each reactor (Water +
(6 Nos)
Brine) followed by
+ HCl,Br2,Cl2,SO2
1 12 common dual scrubbing
Suction hood in Bromine VOC
system (Water + Alkali)
Handling Area
and activated carbon
column
Dual condenser system
on each reactor (Water +
Reactor Vessel Brine) followed by
2 (5 Nos) 12 NH3, VOC common dual scrubbing
system (Water + Acidic)
and activated carbon
column
Dryer
3 12 VOC Activated carbon column
(2 Nos)
Note:
 Details of gaseous raw materials used in proposed project: Chlorine gaseous
raw material is used.
 Estimation of process gas emission (Product wise and total): yes, there will be
the chances of emission of HCL, NH3, Br2 , Cl2, SO2 And to control emission unit

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will provide dual scrubbing system.

 Requirement of the scrubbing media (KL per Day) considering solubility
(Product wise and Total)
 For Ammonia, media used in scrubber will be 1.18 kl/day, for HCl it will be 1.36
kl/day, Cl2 & Br2 and so2 it will be 2.5, So total will be = 5.04 kl/day scrubbing media
is required.
 Yearly generation of all bleed liquors (MT/KL per Annum) as mentioned above
and its sound management in HW matrix.
 2.5 KLD bleed liquor will be generated which will be treated in ETP.
E-4 Fugitive emission details with its mitigation measures.
Sources of fugitive emissions include storage of chemicals, loading
and unloading
Section, raw material handling, hazardous waste storage area.
Mitigation Measures
Water shall be sprinkled during the construction
- Mechanical seals for pumps etc. should be used and maintained.
- Closed unloading, conveying and packing system
- All the reactors shall be closed.
- Safety devices shall be provided to workers
- Raw material storage in closed storage area.

F Hazardous waste
(As per the Hazardous and Other Wastes (Management and
Transboundary Movement) Rules 2016.
Note:
 Priorities for HW Management: Pre-processing, Co-
Processing, Reuse/Recycle within premises, Sell out to
actual users having Rule-9 permission, TSDF/CHWIH.
 Quantification of hazardous waste shall be based on
mass balance and calculations shall be incorporated in
EMP details separately.
 Disposal to scrap vendors/vendors/traders is not
allowed
F-1 Hazardous waste management matrix
-
Category
and
Type/Name of
Sr. Schedule Quantity
Hazardous Management of HW
No. as per (MT/Annum)
waste
HW
Rules.

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Collection, storage, transport and

1 ETP Sludge 35.3 416.16
disposal at approved TSDF site.
Collection, Storage, Transportation
(Through GPS mounted vehicles)
Process and Disposal by sending to
2 28.1 2172.84
Residue registered recycler for regeneration
/for co-processing/ Incinerated at
CHWIF.
Collection, Storage, Transportation
Spent
3 28.3 2357.8 and Incinerated at CHWIF/ for co-
Carbon(process)
processing
Collection, storage reuse with in
Spent Solvent 58485.1
process
4 28.6
Collection, Storage, Transportation
Spent Solvent 142.2 and Incinerated at CHWIF/ for co-
processing
Collection, Storage, Transportation
(Through GPS mounted vehicles)
Distillation and Disposal by sending to
5 20.3 732.7
Residue registered recycler for regeneration
/for co-processing/Incinerated at
CHWIF.
Off Specification Collection, Storage, Transportation
6 28.4 2.3
Drugs and Incinerated at CHWIF.
Date Expired Collection, Storage, Transportation
7 28.5 2.3
Product and Incinerated at CHWIF.
Collection, storage and used within
8 Used Oil 5.1 0.6 premises as a lubricant / sold to
registered recycler.
Discarded
Collection, storage &sold to
9 Plastic Bags / 33.1 267.89
registered recycler.
Barrels / Liners
Collection and sent to ETP for further
598.17
10 Bleed liquor 35.1 Treatment
583.75 Collection, Storage, reuse in process
Collection, Storage, Partially reused,
Transportation (through GPS
mounted vehicle) and Disposed by
11 Spent HBR 28.1 165.48
selling to authorized end user whom
have valid permission from GPCB as
per Haz. Waste Rule-9
Collection, Storage, Transportation
12 MEE Residue 35.3 642.4
and Disposed at TSDF.
F-2 Membership details of TSDF, CHWIF etc.
(For HW management)

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Details of Membership letter no. & Date with spare capacity of the Common Facility.
 Will be obtained after getting EC
F-3 Details of Non-Hazardous waste & its disposal
(MSW and others)
Sr. Type/Name Specific Quantity Management of Wastes
no. of Other Source of (MT/Annum)
wastes generation
(Name of the
Activity,
Product
etc.)
1 Municipal From the 2.7 Waste will be collected
solid waste employs daily by municipal corporation
activity

G Solvent management, VOC emissions etc.

G-1 Brief Note on types of solvents, Details of Solvent recovery, %
recovery, reuse of recovered Solvents etc.

S.No Consumptio Recovere Loss %

Name of Solvent
. n (MT/M) d (MT/M) (MT/M) Recovery

1 1,2-Dimethoxyethane 40.00 38.40 1.60 96.00

2 1,4-Dioxane 42.00 39.48 2.52 94.00
3 2-butanol 11.61 10.75 0.86 92.59
4 Acetic acid 79.62 77.04 2.58 96.76
5 Acetone 365.16 346.05 19.11 94.77
6 Acetonitrile 40.112 38.912 1.20 97.01
7 Benzene 103.5 89.585 13.92 86.56
Bromo-Dimethyl
8 23.84 12.72 11.12 53.36
hydantoin
9 Chloroform 73.8 70.71 3.09 95.81
10 Cyclohexane 39.128 37.56 1.57 95.99
11 Diisopropyl ether 110.208 100.308 9.90 91.02
12 Dimethyl formamide 219.6 206.98 12.62 94.25
13 Ethanol 35.55 28.44 7.11 80.00
14 Ethyl acetate 229.5 219.5 10.00 95.64
15 Ethylene dichloride 274.8 260.74 14.06 94.88
16 Isopropyl alcohol 77.7 74.14 3.56 95.42
17 Mandelic acid 10.9752 10.88 0.10 99.13
18 Methanol 287.2 271.5 15.70 94.53
19 Methylenedichloride 392.344 372.7 19.64 94.99
20 Mono Chloro benzene 153.1 137.65 15.45 89.91
21 n-Hexane 278.4 263.09 15.31 94.50

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22 Tetrahydrofuran 248.08 242.912 5.17 97.92

23 Toluene 496.21 464.054 32.16 93.52
24 Tributyl amine 7.94 7.59 0.35 95.59
25 Xylene 50.4 49.14 1.26 97.50

MT/M 3470.83 219.95

G-2 Brief Note on LDAR proposed:

 The unit will provide solvent recovery system/distillation for the recovery of solvent.
The solvent will be recovered and reused back in manufacturing process. The
solvent will be recovered through distillation process. The distillation is a process
where because of difference in boiling point solvent will be recovered.
 Dual stage condenser (primary cooling water circulation and secondary brine chilling
media circulation) system followed by activated carbon column will be provided to
control VOC attached with process reactor.
 Brief note on LDAR:
Average
Averag
Uncontroll Percentag
Componen e
ed VOC e of total Preventive Measures
ts quantit
Emissions emission
y
(ton/year)
 Use Sealless design
 Use Dual mechanical seal
with barrier fluid
maintained at a higher
pressure than the pumped
fluid
22 4.18 44.16  Provide Closed-vent
Pumps system
 Use Spare pumps at the
time of repair.
 Tightening the packing
glands
 The pump will be flushed of
VOC as much as possible
before opening for seal
replacement.
 Use Sealless design.
 Plug type valves can be
lubricated with grease to
reduce emissions.
Valves 35 1.93 20.39  Many valves have no
means of in-service repair
and must be isolated from
the process.
 Weld together
 In some cases, leaks from
Connectors 63 1.06 11.15 flanges can be reduced by
replacing the flange gaskets.

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 Use of Blind, cap, plug, or

Open second valve will make
ended lines 11 0.18 1.87 100% Control Over
Leakage
Sampling
11 1.51 15.98  Provide Closed-loop
Connection
sampling
s
 Use of Rupture disk
Pressure 11 0.61 6.46 assembly will make 100%
relief valves
Control Over Leakage
G-3 VOC emission sources and its mitigation measures
 Dual stage condenser system (primary cooling water circulation and second Brine
chilled media will be provided as mitigative measure for VOC emission.

H SAFETY details
H-1 Details regarding storage of Hazardous chemicals
(For tank storages only including spent acid and spent solvent
tanks)
 Safety details of Hazardous chemicals (To be stored in
storage tanks)
Given in risk assessment report as Annexure of Form-1.
-
Brief note on storage of Hazardous chemicals in Tanks
Given in risk assessment report as Annexure of Form-1.
Brief note on storage of Hazardous chemicals other than Tanks i.e. Drum, Barrels,
Carboys, Bags etc.
Details of raw material storage and hazardous chemicals are included in risk assessment
report which is attached with form-1
 Safety details of Hazardous Chemicals:
Written in risk report attached as Annexure of Form-1
 Applicability of PESO :
 Unit will obtain explosive certificate after getting EC from the concern authority if
required.
H-2 Types of hazardous Processes involved and its safety
measures:
(Hydrogenation process, Nitration process, Chlorination
process, Exothermic Reaction etc.)
-
Type of Safety measures including Automation
Process

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Nitration Fire / explosion occurred during the nitration process

Control measures:
 Nitration is exothermic reaction leads to runaway reaction. So,
entire process of nitration is to be followed as per standard
operating procedure established by industry.
 All engineering controls w.r.t nitration process i.e. temperature
and pressure controller, jacket surrounding to reactor etc. will be
provided.
 Chilled water to control exothermic reaction during nitration.
 NOx fumes will be scrubbed in ventury Scrubber from the
Nitration reactor.
 Only trained person will be allocated for handling nitration
process.
 Programmable Logic Controller (PLC) based control plan will be
provided for Nitration.
 Direct Contact with skin and eyes will be avoided.
 Appropriate personal protective equipment’s like Safety Gloves,
Goggles, shoes etc., will be provided to workers.
 Periodically inspection of scrubber system will be carried out.
Exothermic Fire/Explosion
reaction Control Measures:
 Exothermic reaction leads to runaway reaction. So, entire process is
to be followed as per standard operating procedure established by
industry.
 All engineering controls w.r.t exothermic reaction i.e. temperature and
pressure controller, jacket surrounding to reactor etc. will be provided.
 Chilled water circulation to control exothermic reaction.
 Only trained person will be allocated to operate.
 Programmable Logic Controller (PLC) based control plan will be
provided.
 Appropriate personal protective equipment’s like Safety Gloves,
Goggles, shoes etc., will be provided to workers.

H-3 Details of Fire Load Calculation

-
Total Plot Area: 3634.9
Area utilized for plant activity: 2419.41

Area utilized for Hazardous Chemicals 410.33

Storage:
Number of Floors: G+1st floor + Second Floor
Water requirement for firefighting in KLD : 7324.35

Water storage tank provided for firefighting 200000

in KLD:
Details of Hydrant Pumps: Yes, 2 electrical pump
(180 lit/min) and 1 diseal

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pump (2280 lit/min) at 7

kg /cm2 pressure.
Nearest Fire Station : Rajkot : 27.8 Km in WSW
direction
Applicability of Off Site Emergency Plan: Shown in Risk Hazards
report.
-
H-4 Details of Fire NOC/Certificate:
Not applicable
H-5 Details of Occupational Health Centre (OHC):
-
Number of permanent Employee: 6
Number of Contractual person/Labor: 0
Area provided for OHC: 15 m2
Number of First Aid Boxes : 4
Nearest General Hospital : Primary Health Centre
Bamanbor: 2.5 Km in NE
direction
Name of Antidotes to be store in plant: Milk Of Magnesia, atropine and
pralidoxime, Amyl nitrite,
ACIDOCTOR – X, paracetamol,
opioids, cardiac glycosides,
organophosphates, Fomepizole

6. Details of Environmental Consultant: [If any]

Sr. Particulars Details
no.
i Name of the Consultant T. R. Associates
ii Contact no. and e-mail ID of the Mo. no. : 09825371099
Consultant e-Mail: [email protected]
iii Accreditation for the categories and Mining of minerals- Opencast mining (Minor
Validity minerals only- Category 1 (a) (i)
Cement Plant – Category 3(b)
Synthetic Organic Chemical – Category 5(f)
Pesticides industry and pesticide specific
intermediate (excluding formulation)- Category
5(b)
Building and Construction project – Category
8(a)
Soda Ash Industry- 4(a)

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B2 EC-New [Updated September 2020]
 Page 43 of 43

Chlor-Alkali Industry- 4(d)

Thermal Power Plants – 1(d)
iv Any other details NABET Accredited vide their Certificate No.
NABET/EIA/1922/RA 0142 (rev 01) issued on
13.09.2019 valid upto 9.10.2022.
I hereby give undertaking that the data and information given in the application and
enclosures are true to the best of my knowledge and belief and I am aware that if any part of
the data and information found to be false or misleading at any stage, the project will be
rejected and Clearance issued if any, to the project, it will be revoked at our risk and cost.
In addition to the above, I hereby give undertaking that no activity / construction / expansion
has since been taken up with respect to the proposed project/activity.

Name & designation

of the Applicant
Mr. Mohitkumar Kishorbhai Dedania (Partner)
M/s. Chemcure lifesciences LLP

Stamp & Signature of Applicant:

Date: 28/09/2020

General Instructions:
 Format shall be in WORD Format (Font type- Arial, Font size- 11)
 Do not change Format. Fill up your details / information in prescribed tables.
 Provide authenticated (with stamp & Signature) hard copy during presentation.
 Do not change alignment of the table. Keep it in center.
 Do not paste certificates / diagrams etc. in the salient feature table except Water
balance diagram.
 Kindly send e-mail to : [email protected]
 Above data shall be as per application Form-1.
 Incorporate relevant details in respective column in the Format. Do not attach
Annexure except copy of Certificates etc.

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B2 EC-New [Updated September 2020]
M/S. CHEMCURE LIFESCIENCES LLP

Annexure 14

Check list for Industrial Projects

For submission of application for EC

Sr. Particulars Tick mark as Page no. of application.

No. applicable
Yes / No
1. All columns of Form 1 (As prescribed in EIA Yes / No -
Notification 2006) properly filled by Project
proponent (PP). [All pages signed by PP]
2. Documents related to Land ownership Yes / No Please refer annexure 12 of
included in EIA report form 1.
3. For 5 (f) category Yes / No Our project falls under category
• Project site is located within GIDC B2 as per EIA notification 2006
• If No, Compliance of following conditions and its amendment.
Water consumption < 25 KLD
Fuel Consumption < 25 MTPD
Non- MAH Unit
4. Contact details Mobile no. and e-Mail ID Yes / No Page No. 3 of Form-1
included in Application
5. Format prescribed by SEAC [Salient features Yes / No SEAC format is attached with
of the project] included with application. form 1.
6. General Condition applicability Yes / No Not applicable
(5) Protected areas notified under the
Wildlife (Protection) Act, 1972;
(6) CEPI areas
(7) Eco-sensitive areas and
(8) Inter-state boundaries and international
boundaries; are not located within 5 km or
10 km (as the case may be) area from the
boundary of the proposed site.
7. In case of Expansion, Compliance status of Yes / No Not applicable
existing unit is included in Format (as per
Format)
8. Violation of EIA Notification 2006 Has any Yes / No Not applicable
construction activity or project activity
started?

If yes, details submitted in this regard

9. Product profile with CAS no. / CI no. Yes / No Page No. 2 of SEAC format
10. Raw Material details and manufacturing Yes / No Page No. 4 of SEAC format.
process of all products with CAS no. / CI no Manufacturing process is
attached as Annexure-4 of form-
1
11. Spent Acids (H2SO4 etc.) generation. Yes / No
If Yes, it is considered as Haz. Waste &
Submitted its management.
12. Details regarding Source of water, Water Yes / No (Annexure - 6 of Form-1)
balance included in Form-1
• Permission to obtain fresh water
• Waste water management,
• Membership certificate of common facility,
• Permission letter for discharge of waste
water etc.
13. Flue gas emission details Included in Form-1 Yes / No (Annexure - 8 of Form-1)
Process gas emission? Yes / No (Annexure - 8 of Form-1)
If yes, Management details Yes / No (Annexure - 8 of Form-1)
M/S. CHEMCURE LIFESCIENCES LLP

14. Hazardous waste generation& its Yes / No (Annexure - 5 of Form-1)

management
15. Spent solvent generation? Yes / No (Annexure - 5 of Form-1)
If, yes Management of spent solvent included Yes / No (Annexure - 5 of Form-1)
in application?
16. Fugitive emissions? Yes / No
If yes, details of its management submitted. Yes / No
17. VOC details included in Application? Yes / No
If yes, details of its management submitted. Yes / No (Annexure - 8 of Form-1)

Above details are true to the best of my knowledge and I am abided to respect the decision of the
SEIAA/SEAC if above information stands wrong in the future and also agree to initiated the legal
proceedings against my project.

Name & Designation of the Applicant:

Mr. Mohitkumar Kishorbhai Dedania (Partner)

Stamp & Signature of Applicant:

Date: 28/09/2020