11 Biology Notes ch19 Excretory Products and Their Elimination 1
11 Biology Notes ch19 Excretory Products and Their Elimination 1
11 Biology Notes ch19 Excretory Products and Their Elimination 1
Elimination of metabolic waste products from the animal body to regulate the composition of body fluids and tissues is
called excretion. These waste products include ammonia, uric acid, urea, carbon dioxide and ions like N a , K , Cl-
+ +
1. A pair of kidneys
2. A pair of ureters
3. A urinary bladder
4. A urethra
Kidneys are reddish brown bean shaped structure situated between last thoracic and lumber vertebra. Each kidney has a
notch on its inner side called hilum through which ureter, blood vessels and nerves enter.
Inside the hilum has broad funnel shaped space called renal pelvis with projection called calyces.
Inside the kidney are two zone- outer cortex and inner medulla. Medulla is divided into medullary pyramids projecting
into calyx.
Cortex extends between medullary pyramids as renal column called Columns of Bertini.
The functional unit of kidney is nephron. Each kidney contains about one million nephrons.
Each nephron has two parts- the glomerulus and renal tubules. Glomerulus is the tuft of capillaries formed by afferent
arteriole. Blood from glomerulus is carried away by efferent arteriole.
Renal tubules starts with Bowman’s capsule continue with tubular parts divided into Proximal Convoluted tubules,
Henle’s loop and Distal Convoluted tubule.
The malpighian tubules, PCT and DCT of nephron are situated in cortical region where as loops of Henle’s into medulla.
Urine formation
Function of Tubules
1. Proximal Convoluted Tubules (PCT) - all the important nutrients, 70-80% electrolytes and water are reabsorbed.
2. Henle’s Loop- maintains high osmolarity of medullary interstitial fluid.
3. Distal Convoluted Tubules (DCT) – conditional reabsorption of Na+ and water. Maintains pH and sodium- potassium
balance.
4. Collecting Duct- large amount of water is reabsorbed to produce concentrated urine.
Mechanism of concentration of urine- The flow of filtrate in two limbs of Henle’s loop is in opposite direction to form
counter current. The flow of blood in two limbs of vasa recta increase the osmolarity towards the inner medullary interstitium in
the inner medulla.
The transport of substance facilitated by special arrangement of Henle’s loop and vasa recta is called counter current
mechanism.
Functioning of kidney is monitored by hormonal feedback mechanism of hypothalamus and JGA. Change in blood
volume, body fluid and ion concentration activates the osmoreceptors in the body that stimulate the hypothalamus to
release ADH or vasopressin hormones. The ADH facilitates water absorption in tubules.
Decrease in glomerular blood pressure activate JG cells to release renin which converts angiotensinogen to angiotensin I
and II that increase the glomerular blood pressure and release of aldosterone that increase absorption of Na+ ions and
water.
Micturition – The process of expulsion of urine from the urinary bladder is called micturition. The neural mechanism that
causes it is called micturition reflex. Urine formed in nephron is stored in urinary bladder till a voluntary signal is given by
CNS. This initiates the contraction of smooth muscles of the bladder and simultaneous relaxation of the urethral sphincter
causing the release of urine.
bile containing substances like bilirubin, biliverdin. Sweat glands remove NaCl, small amount of urea and lactic acid.
Sebaceous glands excrete sterol, hydrocarbons and waxes.
Uremia- there is high concentration of non-protein nitrogen (urea, uric acid, creatinine). Urea can be removed by
hemodialysis.
Renal failure- also known as kidney failure where glomerular filtration is ceased and both kidney stops working.
Kidney transplant is the ultimate method in correction of acute kidney failure.
Renal Calculi- formation of stone or insoluble mass of crystallized salts formed within the kidney.
Glomerulonephritis (Bright’s Disease)-inflammation of glomeruli of kidney due to entry of protein or red blood
corpuscles in to filtrate due to injury.