SAFETY DATA SHEET

Revision Date 16-Mar-2019 Revision Number 4

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING

1.1. Product identification

Product Description: 4-(3,5-Dimethyl-1H-pyrazol-1-yl)aniline, 97%

Cat No. : SEW04169DA; SEW04169EA; SEW04169ZZ; SEW04169FL; SEW04169R3;
SEW04169SC
Molecular Formula C11 H13 N3

1.2. Relevant identified uses of the substance or mixture and uses advised against

Recommended Use Laboratory chemicals.

Uses advised against No Information available

1.3. Details of the supplier of the safety data sheet

Company UK entity/business name .

Maybridge
Thermo Fisher Scientific
Bishop Meadow Rd
Loughborough, Leicestershire, Great Britain
LE11 5RG
Tel: 01509 231166
Website: www.maybridge.com

EU entity/business name
Acros Organics BVBA
Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium

E-mail address [email protected]

1.4. Emergency telephone number

For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887

SECTION 2: HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture

CLP Classification - Regulation (EC) No 1272/2008

Physical hazards

Based on available data, the classification criteria are not met

Health hazards
Based on available data, the classification criteria are not met
Skin Corrosion/irritation Category 2 (H315)

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Serious Eye Damage/Eye Irritation Category 2 (H319)
Specific target organ toxicity - (single exposure) Category 3 (H335)

Environmental hazards
Based on available data, the classification criteria are not met

2.2. Label elements

Signal Word Warning

Hazard Statements
H315 - Causes skin irritation
H335 - May cause respiratory irritation
H319 - Causes serious eye irritation

Precautionary Statements
P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing

2.3. Other hazards

No information available

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

Component CAS-No EC-No. Weight % CLP Classification - Regulation (EC) No

1272/2008
4-(3,5-Dimethyl-1H-pyrazol-1-yl)aniline, 52708-32-4 100 STOT SE 3 (H335)
97% Skin Irrit. 2 (H315)
Eye Irrit. 2 (H319)

Full text of Hazard Statements: see section 16

SECTION 4: FIRST AID MEASURES

4.1. Description of first aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
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medical attention.

Skin Contact Wash off immediately with soap and plenty of water while removing all contaminated
clothes and shoes. Obtain medical attention.

Ingestion Clean mouth with water. Get medical attention.

Inhalation Remove from exposure, lie down. Move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Obtain medical attention.

Self-Protection of the First Aider Ensure that medical personnel are aware of the material(s) involved, take precautions to
protect themselves and prevent spread of contamination.

4.2. Most important symptoms and effects, both acute and delayed

No information available.

4.3. Indication of any immediate medical attention and special treatment needed

Notes to Physician Treat symptomatically.

SECTION 5: FIREFIGHTING MEASURES

5.1. Extinguishing media

Suitable Extinguishing Media

Water spray. Carbon dioxide (CO 2). Dry chemical. Chemical foam.

Extinguishing media which must not be used for safety reasons

No information available.

5.2. Special hazards arising from the substance or mixture

Thermal decomposition can lead to release of irritating gases and vapors.

Hazardous Combustion Products

Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO2).

5.3. Advice for firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

Ensure adequate ventilation.

6.2. Environmental precautions

Prevent further leakage or spillage if safe to do so.

6.3. Methods and material for containment and cleaning up

Sweep up or vacuum up spillage and collect in suitable container for disposal.

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6.4. Reference to other sections

Refer to protective measures listed in Sections 8 and 13.

SECTION 7: HANDLING AND STORAGE

7.1. Precautions for safe handling

Avoid contact with skin and eyes. Do not breathe dust. Do not breathe vapors or spray mist.

Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do
not eat, drink or smoke when using this product. Remove and wash contaminated clothing before re-use. Wash hands before
breaks and at the end of workday.

7.2. Conditions for safe storage, including any incompatibilities

Keep in a dry, cool and well-ventilated place. Keep container tightly closed.

7.3. Specific end use(s)

Use in laboratories

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1. Control parameters

Exposure limits
This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region
specific regulatory bodies

Biological limit values

This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
regulatory bodies

Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of
exposure to chemical and biological agents.

Derived No Effect Level (DNEL) No information available

Route of exposure Acute effects (local) Acute effects Chronic effects Chronic effects
(systemic) (local) (systemic)
Oral
Dermal
Inhalation

Predicted No Effect Concentration No information available.

(PNEC)

8.2. Exposure controls

Engineering Measures
Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the
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workstation location.
Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or
equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to
control hazardous materials at source

Personal protective equipment

Eye Protection Goggles (European standard - EN 166)

Hand Protection Protective gloves

Glove material Breakthrough time Glove thickness EU standard Glove comments

Disposable gloves See manufacturers - EN 374 (minimum requirement)
recommendations
Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure

Inspect gloves before use.

Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger
of cuts, abrasion.
Remove gloves with care avoiding skin contamination.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.
To protect the wearer, respiratory protective equipment must be the correct fit and be used
and maintained properly

Large scale/emergency use In case of insufficient ventilation wear suitable respiratory equipment

Small scale/Laboratory use Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure
limits are exceeded or if irritation or other symptoms are experienced.
When RPE is used a face piece Fit Test should be conducted

Environmental exposure controls No information available.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Appearance No information available

Physical State Solid

Odor No information available

Odor Threshold No data available
pH No data available
Melting Point/Range No data available
Softening Point No data available
Boiling Point/Range No information available
Flash Point No information available Method - No information available
Evaporation Rate No data available
Flammability (solid,gas) No information available
Explosion Limits No data available

Vapor Pressure No data available

Vapor Density No data available (Air = 1.0)
Specific Gravity / Density No data available
Bulk Density No data available
Water Solubility No information available
Solubility in other solvents No information available
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Partition Coefficient (n-octanol/water)
Autoignition Temperature No data available
Decomposition Temperature No data available
Viscosity No data available
Explosive Properties No information available
Oxidizing Properties No information available

9.2. Other information

Molecular Formula C11 H13 N3

Molecular Weight 187.24

SECTION 10: STABILITY AND REACTIVITY

10.1. Reactivity
None known, based on information available

10.2. Chemical stability

Stable under normal conditions.

10.3. Possibility of hazardous reactions

Hazardous Polymerization No information available.

Hazardous Reactions No information available.

10.4. Conditions to avoid

Incompatible products.

10.5. Incompatible materials

Strong oxidizing agents.

10.6. Hazardous decomposition products

Nitrogen oxides (NOx). Carbon monoxide (CO). Carbon dioxide (CO2).

SECTION 11: TOXICOLOGICAL INFORMATION

11.1. Information on toxicological effects

Product Information No acute toxicity information is available for this product

(a) acute toxicity;

Oral No data available
Dermal No data available
Inhalation No data available

(b) skin corrosion/irritation; No data available

(c) serious eye damage/irritation; No data available

(d) respiratory or skin sensitization;

Respiratory No data available
Skin No data available

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(e) germ cell mutagenicity; No data available

(f) carcinogenicity; No data available

There are no known carcinogenic chemicals in this product

(g) reproductive toxicity; No data available

(h) STOT-single exposure; No data available

Results / Target organs Respiratory system.

(i) STOT-repeated exposure; No data available

Target Organs No information available.

(j) aspiration hazard; No data available

Other Adverse Effects The toxicological properties have not been fully investigated.

Symptoms / effects,both acute and No information available

delayed

SECTION 12: ECOLOGICAL INFORMATION

12.1. Toxicity
Ecotoxicity effects Contains no substances known to be hazardous to the environment or that are not
degradable in waste water treatment plants.

12.2. Persistence and degradability No information available

12.3. Bioaccumulative potential No information available

12.4. Mobility in soil No information available

12.5. Results of PBT and vPvB No data available for assessment.

assessment

12.6. Other adverse effects

Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant This product does not contain any known or suspected substance
Ozone Depletion Potential This product does not contain any known or suspected substance

SECTION 13: DISPOSAL CONSIDERATIONS

13.1. Waste treatment methods

Waste from Residues / Unused Chemical waste generators must determine whether a discarded chemical is classified as a
Products hazardous waste. Consult local, regional, and national hazardous waste regulations to
ensure complete and accurate classification.

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Contaminated Packaging Empty remaining contents. Dispose of in accordance with local regulations. Do not re-use
empty containers.

European Waste Catalogue (EWC) According to the European Waste Catalogue, Waste Codes are not product specific, but
application specific.
Other Information Waste codes should be assigned by the user based on the application for which the product
was used.

SECTION 14: TRANSPORT INFORMATION

IMDG/IMO Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

ADR Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

IATA Not regulated

14.1. UN number
14.2. UN proper shipping name
14.3. Transport hazard class(es)
14.4. Packing group

14.5. Environmental hazards No hazards identified

14.6. Special precautions for user No special precautions required

14.7. Transport in bulk according to Not applicable, packaged goods

Annex II of MARPOL73/78 and the
IBC Code

SECTION 15: REGULATORY INFORMATION

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

International Inventories X = listed.

National Regulations

Take note of Control of Substances Hazardous to Health Regulations (COSHH) 2002 and 2005 Amendment.

15.2. Chemical safety assessment

A Chemical Safety Assessment/Report (CSA/CSR) has not been conducted

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SECTION 16: OTHER INFORMATION

Full text of H-Statements referred to under sections 2 and 3

Legend

CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS - European Inventory of Existing Commercial Chemical DSL/NDSL - Canadian Domestic Substances List/Non-Domestic
Substances/EU List of Notified Chemical Substances Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances
IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals

WEL - Workplace Exposure Limit TWA - Time Weighted Average

ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer
DNEL - Derived No Effect Level PNEC - Predicted No Effect Concentration
RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50%
LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50%
NOEC - No Observed Effect Concentration POW - Partition coefficient Octanol:Water
PBT - Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative

ADR - European Agreement Concerning the International Carriage of ICAO/IATA - International Civil Aviation Organization/International Air
Dangerous Goods by Road Transport Association
IMO/IMDG - International Maritime Organization/International Maritime MARPOL - International Convention for the Prevention of Pollution from
Dangerous Goods Code Ships
OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate
BCF - Bioconcentration factor VOC - Volatile Organic Compounds
Key literature references and sources for data
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS

Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and
hygiene.

Revision Date 16-Mar-2019

Revision Summary Not applicable.

This safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of Safety Data Sheet

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