Ctma 2018

CTMA 2
Canada’s Trusted Reference for

Minor Ailments
Sample Chapters for Conference_J.indd 1 6/17/2016 2:35:16 PM

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Table of Contents
Editorial Advisory Committee ................................................................................................vii
Authors ........................................................................................................................... viii
Reviewers ........................................................................................................................ ix
Editor's Message ................................................................................................................ x
Editorial Policy, Description and Limitations of Information........................................................... xi
How to Use Compendium of Therapeutics for Minor Ailments ......................................................xii
Patient Assessments ......................................................................................................... xiii
Communicating With Patients

1 Effective Pharmacist-patient Interactions, Barbara J. Farrell ................................................... 1
2 Facilitating Behaviour Change, Lisa Dolovich .................................................................... 12
3 Pharmacist Assessment of the Self-treating Patient, Nardine Nakhla ...................................... 21
Psychiatric Conditions
4 Depression, Ric M. Procyshyn and Alasdair M. Barr............................................................ 27
5 Insomnia, Ric M. Procyshyn and Alasdair M. Barr............................................................... 38
6 Smoking Cessation, Kristine Petrasko and Manjit Bains....................................................... 52
Central Nervous System Conditions

7 Fever, Yvonne M. Shevchuk .......................................................................................... 82
8 Headache, Irene Worthington ........................................................................................ 99
9 Heat-related Disorders, Dorothy Tscheng ........................................................................117
10 Tinnitus, Yvonne M. Shevchuk ..................................................................................... 128
11 Vertigo and Dizziness, Yvonne M. Shevchuk ................................................................... 132
Eye Care
12 Assessment of Patients with Eye Conditions, Anne M. Friesen............................................ 139
13 Conjunctivitis, Anne M. Friesen .................................................................................... 140
14 Contact Lens Care, David S. Wing and Ken Gellatly ......................................................... 148
15 Dry Eye, Anne M. Friesen ........................................................................................... 162
16 Eyelid Conditions: Hordeolum, Chalazion and Blepharitis, Anne M. Friesen ........................... 169
Ear Conditions
17 Assessment of Patients with Hearing Loss, Ear Pain and Ear Drainage, Yvonne M.
Shevchuk ................................................................................................................ 187
18 Complications Affecting the Ear: Ear Piercing, Foreign Bodies and Barotrauma, Yvonne M.
Shevchuk ................................................................................................................ 193
19 Impacted Earwax, Yvonne M. Shevchuk......................................................................... 198
Compendium of Therapeutics for Minor Ailments Copyright © Canadian Pharmacists Association. All rights reserved.

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20 Otitis Media and Otitis Externa, Yvonne M. Shevchuk ....................................................... 206
Respiratory Conditions
21 Acute Cough, Daniel J.G. Thirion.................................................................................. 217
22 Allergic Rhinitis, Jennifer Kendrick ................................................................................ 226
23 Assessment of Patients with Upper Respiratory Tract Symptoms, Daniel J.G. Thirion .............. 249
24 Viral Rhinitis, Influenza, Rhinosinusitis and Pharyngitis, Daniel J.G. Thirion ........................... 254
Metabolic and Cardiovascular Conditions

25 Diabetes Care, Lori MacCallum .................................................................................... 273
26 Diabetes Care Devices, Ronald Silver ........................................................................... 293
27 Lifestyle Management and Disease Prevention, L. Maria Gutschi ........................................ 302
Gastrointestinal Conditions
28 Assessment of Patients with Abdominal Pain, Peter Thomson ............................................ 323
29 Constipation, Jane Bowles-Jordan ................................................................................ 327
30 Diarrhea, Antonietta Forrester ...................................................................................... 353
31 Dyspepsia and GERD, Co Q. D. Pham .......................................................................... 378
32 Gastrointestinal Gas, Co Q. D. Pham............................................................................. 390
33 Hemorrhoids, Joyce Chan ........................................................................................... 398
34 Infant Colic, Shelita Dattani ......................................................................................... 407
35 Irritable Bowel Syndrome, Lynette Kosar ........................................................................ 420
36 Nausea and Vomiting, Christine Hughes ........................................................................ 429
37 Ostomy Care, Marie Berry........................................................................................... 448
38 Perianal Symptom Assessment, Joyce Chan .................................................................. 463
39 Pinworms, Joyce Chan ............................................................................................... 465
Nutrition
40 Infant Nutrition, Joan Brennan-Donnan .......................................................................... 472
41 Special Diets, Shirley Heschuk..................................................................................... 491
42 Sports Nutrition, Shirley Heschuk.................................................................................. 506
43 Weight Management, Shirley Heschuk........................................................................... 519
Musculoskeletal Conditions
44 Drug Use and Abuse in Sports, Lily Lum......................................................................... 547
45 Low Back Pain, Kelly Grindrod, Jason Kielly and Carlo Marra ............................................. 554
46 Osteoarthritis, Kelly Grindrod, Jason Kielly and Carlo Marra ............................................... 569
47 Osteoporosis, Lalitha Raman-Wilms and Anne Marie Whelan ............................................. 590
48 Sports Injuries, Lily Lum.............................................................................................. 608
Foot Conditions
Copyright © Canadian Pharmacists Association. All rights reserved. Compendium of Therapeutics for Minor Ailments

45 Low Back Pain, Kelly Grindrod, Jason Kielly and Carlo Marra ............................................. 554
46 Osteoarthritis, Kelly Grindrod, Jason Kielly and Carlo Marra ............................................... 569
47 Osteoporosis, Lalitha Raman-Wilms and Anne Marie Whelan ............................................. 590
48 Sports Injuries, Lily Lum.............................................................................................. 608
Foot Conditions
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49 Assessment of Foot Symptoms, Anne Mallin ................................................................... 621
50 Athlete's Foot, Anne Mallin .......................................................................................... 623
51 Corns, Calluses, Bunions and Ingrown Toenails, Anne Mallin.............................................. 631
52 Plantar Warts, Anne Mallin .......................................................................................... 641
Dermatologic Conditions
53 A Summary of Common Skin Conditions, Penny F. Miller ................................................... 648
54 Acne, Debra Sibbald .................................................................................................. 653
55 Atopic, Contact, and Stasis Dermatitis, Debra Sibbald ....................................................... 682
56 Bacterial Skin Infections: Impetigo, Furuncles and Carbuncles, Penny F. Miller ....................... 716
57 Burns, Nancy Kleiman ................................................................................................ 730
58 Dandruff and Seborrheic Dermatitis, Debra Sibbald .......................................................... 740
59 Diaper Dermatitis, Debra Sibbald.................................................................................. 760
60 Dressings, Marie Berry ............................................................................................... 779
61 Drug-induced Skin Reactions, Sandra Knowles ............................................................... 786
62 Dry Skin, Nancy Kleiman ............................................................................................ 802
63 Frostbite, Nancy Kleiman ............................................................................................ 809
64 Fungal Nail Infections (Onychomycosis), Penny F. Miller.................................................... 818
65 Fungal Skin Infections, Penny F. Miller ........................................................................... 827
66 Hair Care and Hair Growth, Nancy Kleiman .................................................................... 842
67 Insect Bites and Stings, Nancy Kleiman ......................................................................... 861
68 Minor Cuts and Wounds, Nancy Kleiman........................................................................ 877
69 Parasitic Skin Infections: Lice and Scabies, Penny F. Miller ................................................ 886
70 Perspiration and Body Odour, Nancy Kleiman ................................................................. 904
71 Psoriasis, Debra Sibbald............................................................................................. 915
72 Prevention and Treatment of Sun-Induced Skin Damage, Nancy Kleiman.............................. 939
73 Viral Skin Infections: Common and Flat Warts, Penny F. Miller ............................................ 956
74 Viral Skin Rashes, Sandra Knowles............................................................................... 968
Reproductive, Gynecologic and Genitourinary Health

75 Benign Prostatic Hyperplasia and Associated Lower Urinary Tract Symptoms, Cheryl A.
Sadowski ................................................................................................................ 985
76 Contraception, Anne Marie Whelan ............................................................................... 999
77 Dysmenorrhea, Thomas E.R. Brown ............................................................................ 1031
78 Male Sexual Dysfunction, Tom Smiley .......................................................................... 1041
79 Menopause and Perimenopause, Thomas E.R. Brown ..................................................... 1054
80 Pregnancy and Fertility Testing, Marie Berry................................................................... 1067
81 Premenstrual Syndrome, Thomas E.R. Brown ................................................................ 1074
82 Prenatal and Postpartum Care, Carla Dillon ................................................................... 1090
83 Urinary Incontinence, Cheryl A. Sadowski ..................................................................... 1132
84 Vaginal Symptoms, Hygiene and Infections, Laura-Lynn Pollock......................................... 1145

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Dental Health
85 Dental Conditions, Michelle Bourassa........................................................................... 1167
86 Oral Hygiene, Dental Plaque and Caries, Michelle Bourassa ............................................. 1176
87 Periodontal Conditions: Gingivitis and Periodontitis, Michelle Bourassa ............................... 1188
88 Teething, Michelle Bourassa ....................................................................................... 1201
Mouth Conditions
89 Aphthous Ulcers (Canker Sores), Adeline T. Chau Markarian............................................. 1209
90 Cold Sores (Herpes Labialis), James S. Conklin ............................................................. 1220
91 Dry Mouth, Victoria Kletas .......................................................................................... 1232
92 Halitosis, Shirin Abadi ............................................................................................... 1242
93 Oral Candidiasis, Karen Wlock .................................................................................... 1249
General Appendices
I Complementary and Alternative Therapies, Cynthia Richard and Paul A. Spagnuolo .............. 1258
II Home Testing, Marie Berry ......................................................................................... 1278
III Information for the Traveller, Mark Kearney .................................................................... 1289
IV Medical Devices and Aids to Daily Living, Marie Berry ...................................................... 1304
V Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions, Myla E.
Moretti ................................................................................................................... 1320
VI Nutritional Supplements, L. Maria Gutschi ..................................................................... 1329

Effective Pharmacist-Patient Interactions
Barbara J. Farrell, BScPhm, PharmD

Date of Revision: April 2016
Introduction
Throughout an interaction, the participants (e.g., the pharmacist and the patient) alternate between the roles
of “sender” and “receiver” of the message. Information should not be provided in a unidirectional manner.
Rather, information is exchanged. As a receiver, the pharmacist has the responsibility of listening to what the
patient is saying, understanding the issue and providing feedback on whether the message was understood.
As the sender, the pharmacist has the responsibility of transmitting the message clearly, in language
understood by the patient and in an environment conducive to clear transmission.
For effective patient interaction consider 2 major components—how the interaction is organized, and how
well the pharmacist uses communication skills. Use of verbal and nonverbal communication skills
throughout the interaction ensures that a full description of the presenting complaint and associated
symptoms, as well as other relevant information, are gathered from the patient.
There are 3 major stages or types of patient interactions: assessment and triage, counselling, and follow up.
The chapter provides guidance on how these interactions can be organized and examples of the topics and
questions that could be included. Further detailed discussion of the process of assessment and triage can
be found in Pharmacist Assessment of the Self-treating Patient.
Assessment and Triage

The primary purposes of this stage of the interaction with a patient are to determine the nature of the
patient's concerns or symptoms, and to help the patient determine whether self-treatment with a pharmacy
product is appropriate or referral to another provider is necessary. A pharmacy technician or pharmacist
may initially respond to a request from a patient in the pharmacy. The pharmacy technician will need to use
these initial steps in greeting the patient—finding out in a general way about the problem and ensuring
comfort and privacy, then engaging the pharmacist in conducting the patient interview and assessment
process. The emphasis is on skillfully eliciting relevant information from the patient so that the pharmacist
gains a complete picture of the patient's issue and does not jump to conclusions about what the patient
needs. This is also the point at which the pharmacist begins to build rapport with patients and earn their
trust.
How
Introduce yourself or greet the patient by name if you know him or her
Find out briefly what the patient needs
Explain, in a general way, how you can help
Ensure comfort and privacy to impress that you are concerned about how the patient is feeling and
value the importance of confidentiality
Proceed with questioning, listening and basic physical assessment (if required), for assessment
and triage. Suggestions for the assessment process are found in Pharmacist Assessment of the
Self-treating Patient.
Examples of statements and questions that can be used at each stage are listed in Figure 1.
Use good communication skills. This will help you send messages in a manner that can be understood
by the patient and will help you understand the messages that you receive. Both verbal and nonverbal
communication skills are important and should reflect one another. Good verbal communication skills
and poor or distracting nonverbal skills send conflicting messages, and the patient may lose confidence
in the pharmacist. The reverse is also true.
Figure 1: What to Say when Assessing Patients
Verbal communication skills include: the ability to question appropriately (Table 1), speaking in language
that the patient can understand (Table 2), listening effectively (Table 3) and responding using empathy
(Table 4).
Nonverbal communication transmits more than half of the messages that people send and receive.
These skills must be practised when the pharmacist is both speaking and listening to the patient.
Techniques to optimize nonverbal communication are outlined in Table 5.
The importance of listening and being empathetic, through effective verbal and nonverbal
communication, cannot be underestimated. Spending time without being distracted, as well as
understanding patient feelings and perspectives without judging, criticizing or blaming, builds
acceptance and respect that creates a therapeutic alliance.
Table 1: Question Appropriately

Use open-ended questions: Use closed-ended questions: Avoid:
Avoid
When you need to When you want a yes, no Using only open-ended
gather symptom or number response questions (will make the
information that is When you want to discussion much longer
uppermost in the gather specific, focused and unfocused)
patient's mind information about the Using only closed-ended
When you need to begin nature of the symptoms questions (will prevent
a line of questioning and treatment discussion from moving
When you want to When you need to to details of which you
determine the patient's gather information are unaware, may create
understanding, level of quickly passivity)
sophistication of their When you need to keep Asking several
assessment of the a talkative patient questions in succession
problem and what level focused without patient input.
of vocabulary would be For example asking, is
appropriate for you to Examples: the pain mostly in your
use Do you... (have any stomach or is it more
To convey a willingness discharge?) like heartburn? What
to listen Have you... (ever had does it feel like? Do you
this before?) usually get it after you
To promote rapport and eat? (one after another
trust Will you... (be able to without giving the
Examples: take this every 4 hours?) patient a chance to
Describe... (the feeling How many times... (do answer)
to me) you wake up during the Asking leading or biased
night?) questions. For example,
Explain... (how the pain
feels) “There isn't any blood in
your stool, is there?”
Tell me about... (the
heartburn) Asking questions that
start with “why” (can
How... (does the seem judgmental and
headache feel?) cause defensiveness)
What... (brings you in Using slang or medical
today?) terminology
Table 2: Speak at an Appropriate Language Level

Use: Not: Use: Not:
A lot of phlegm Productive Digestive system Gastrointestinal
High blood pressure Hypertension Lower Decrease
Painkiller Analgesic Raise Increase or elevate
Cough suppressant Antitussive Condition Diagnosis
Shooting pain Radiating pain How bad Severity
Bum Rectum On the skin Topically
Table 3: Listen Effectively

You are listening when you: You are not listening when you:
Encourage talking (e.g., hmm, yes, go on) Are in a hurry (looking at watch)
Wait during silence (allows the patient a Interrupt
chance to think and react) Change subject for no apparent
Repeat (so you're having difficulty sleeping) reason
Reflect (why do you think that) Ask a question twice
Explore (could you say a bit more about that) Don't ask any questions at all
Summarize accurately Are talking
Ask questions Don't allow the patient a chance to
Paraphrase finish speaking
Lecture
Cut off expressions of feeling
Give advice prematurely
a
Table 4: Respond Effectively
Avoid automatically giving the following
responses until you understand what the
Use empathy patient is feeling
Make an effort to understand how the Judgmental or critical responses (You

patient is feeling;b respond to that shouldn't be doing that)
feeling Advising/recommending responses
Some of what the patient tells you Reassuring responses (You'll be fine)
involves their feelings about it; be Generalizing responses (Everybody feels
sensitive to those feelings that way)
Distracting responses, e.g., changing the
subject
a Some responses will be factual but always consider why the patient raised the point or asked the question.
b You can learn a lot about a patient's feelings by observing their nonverbal behaviour: do they look sad? frustrated?
angry? weak or sick? worried? in pain?

Table 5: Nonverbal Communication
Do Do not
Smile Look down or
Demonstrate genuine interest and concern away repeatedly
Maintain eye contact as culturally, socially and gender Look at or play
appropriate with other
objects
Use appropriate body language (show interest and concern in repeatedly
your facial expression, maintain appropriate distance from the
patient, keep your body posture open, lean forward) Cross your arms
or your legs
Sit or squat if the patient is sitting, stand if the patient is
standing Use distracting
gestures
Have a neat and clean personal appearance and a neat and
clean physical environment Tilt to one side
Slouch
Stare
Get so close that
you are in the
patient's
“personal space”
Have barriers
between you and
the patient (high
counter)
Counselling
The main purposes of this stage of interaction are to assist with product selection and provide counselling
that will enable the patient to gain the most benefit from the product. Again, the pharmacist acts as both
“sender” and “receiver” of messages, but with more emphasis on sending messages to the patient. To
ensure counselling is effective, pharmacists need to pay attention to transmitting their message clearly and
explicitly without adhering to a strict monologue type of counselling routine. They need to continually check
for understanding throughout and pay attention to new information that the patient may offer.
How
Establish goals
Help with product selection
Provide information (while continuing to listen to the patient for new information)
Check for understanding
Close
Use communication skills. The same skills highlighted in the Follow Up section apply.
Additional verbal skills that are useful in the counselling component of the interaction include the rate,
volume, tone and pitch of speech. These are outlined in Table 6.
The nonverbal skills used in counselling are the same as those used in assessment and triage. You may
need to use additional nonverbal skills to indicate the closure of the interaction. Examples are standing
up (if sitting), changing stance, shaking hands and sometimes packing up papers or putting pen and
paper away.
Figure 2: What to Say when Counselling Patients

Follow Up
Use follow up to determine whether the patient's goals were achieved with the plan selected and that no red
flag has arisen that would require referral for medical treatment. Follow up is similar in format to a
combination of both the assessment/triage phase and the counselling phase. Ideally, it's best if the same
person can provide the follow up as this is the person with whom the patient has developed a relationship.
Let the patient know you would like to call within a few days to ensure that the plan is working and that no
problems have developed with the medication. Patients appreciate this and are often happy to arrange a
time for you to call.
How
Introduce yourself
Explain purpose of follow up
Assess response
Advise if necessary
Close
Table 6: Speaking Skills

Do Do not
Slow down; Increase the rate of speech (tempting when you have a lot of
resist the information to provide)
temptation Speak so loudly that others in the pharmacy can also hear you (have
to another staff member tell you if your conversation was heard)
“download”
information Speak in a condescending or patronizing manner
quickly, e.g., Speak in a monotonous voice pitch (boring)
learn to Raise your pitch at the end of a sentence (sounds like you are
pause when questioning yourself)
there are
Hand out printed written information without also providing verbal
periods or
counselling
natural
commas in
your
sentences.
This helps
the patient
digest the
information
and provides
an
opportunity
for them to
speak if they
have a
question or
another
piece of
information
to provide
Speak loudly
enough so
the patient
can hear you
Speak in a
friendly tone
Raise and
lower the
pitch of your
voice
appropriately
(lower at the
end of
sentences;
lower if
patient is
hard of
hearing)
Use precise
language,
e.g., “with an
8-oz glass of
water,” not
“with plenty
of water;” or
“one hour
before a
meal,” not
“on an empty
stomach”
Write
information
down when
verbal
explanation
is not
sufficient
Use good communication skills. A major difference between this type of interaction and the
assessment/triage and counselling interactions is that this discussion often takes place over the
telephone. Since neither you nor the patient will be able to read each other's nonverbal cues, particular
attention must be paid to clear verbal communication. Verbal skills are outlined in Table 7.
The nonverbal messages you send will confirm your real interest in and concern for the patient. They will
also make it easier for both of you to hear each other. Techniques for optimizing nonverbal
communication during telephone conversations are outlined in Table 8.
Table 7: Verbal Skills to Use Over the Telephone

Do
Start with a friendly greeting

Speak more slowly than you would face to face
Enunciate clearly
Let the patient know if you need to stop talking to write something down or pause to think
If you use a speaker phone confirm that the patient can hear you
Hold the receiver an appropriate distance from your mouth so that your voice is not
muffled or too soft
Table 8: Nonverbal Skills to Use During Telephone Conversations

Do Do not
Be prepared Put the patient on hold

Give your full attention to the phone call Be interrupted
Smile to help ensure your voice carries a friendly tone Have background noise,
Listen carefully to the tone of the patient's voice and e.g., voices, music, ringing
speech in order to determine concerns or telephones
misunderstanding Be overheard by other
people
Figure 3: What to Say at Follow Up
Tips for Special Situations

Tips for interacting with the talkative patient who gets off topic:
Minimize your contribution to the “off topic”

Acknowledge but continue returning to the questioning or counselling; if possible, try to link the therapy
discussion to the “off topic,” e.g., patient starts talking about husband's death 10 years ago; ask “Is that
when your stomach problems started?” then focus discussion back on today's presenting complaint
Try referring back to the discussion about the presenting complaint and introducing a closed-ended
question (e.g., “A few minutes ago, you said that you were having trouble sleeping; have you had this
problem before?”), then continue with the line of questioning.
Tips for interacting with the angry patient:
Remember that feelings of hostility are rarely personal; the patient may be under a great deal of stress
Acknowledge anger
Let patients vent their anger
Stay calm
Lower your voice, speak slowly and maintain eye contact
If you are at fault, agree; agreeing often diffuses anger
Avoid defensiveness (which can aggravate the situation).
Tips for interacting with the depressed/upset/crying patient:
Offer privacy, tissues, time alone

Offer to call someone
Ask “Is it something you want to talk about?”
Tips for interacting with the patient who does not want to see their doctor:
Explain your reasons for concern; be assertive, e.g., “When diarrhea goes on longer than 2 weeks, I
worry that there could be something serious going on; it's important to see a doctor because they can
tell if there are any serious problems.”
Tips for interacting with patients who do not want to take your advice:
Determine preferences before recommending a product

Explain advantages and disadvantages in terms of patient's medications and medical conditions
Consider “rolling with it”; sometimes resistance is normal (think of products to help with smoking
cessation); consider using techniques of motivational interviewing described in Facilitating Behaviour
Change, if behaviour change is challenging.
Tips for interacting with the patient with hearing impairment:
Ask if the patient can hear you

Ask if better to speak to one side
Face the patient so they can read your lips
Speak more slowly, enunciate clearly and lower your tone of voice to make it easier for the patient to
differentiate words
Increase your volume of speech but don't shout
Use short, simple sentences
Keep in mind that your facial expression, body posture and gesture are as important as lip movements
for the patient to understand what you are saying.
Tips for interacting with the patient with vision impairment:
Tell the patient what you are doing and if there is anyone else present, e.g., a student
If writing information, use large print and pastel-coloured paper rather than white.
Tips for interacting with the patient with cognitive impairment:
Speak slowly
Allow time for patient to answer questions
Write information down.
Tips for interacting with the noncommunicative patient:
Wait during silence so the patient can respond

Ask open-ended questions.
Tips for interacting with the patient with a potentially embarrassing complaint:
Offer privacy
Use closed-ended questions for assessment, e.g., “Do you have any discharge? Is it clear or white?” not
“Tell me about the discharge.”
Tips for interacting with the elderly patient:

Slow down your rate of speech
Decrease the amount of information given at one time.
Tips for interacting with the patient with speech impairment:
Speak slowly
Face the patient
Let the patient finish speaking
Provide writing pads
Learn simple sign language if used by the patient.
Tips for interacting with the patient who does not speak your language:
Speak slowly and simply

Use an interpreter, e.g., caregiver.
Tips for interacting with the aphasic patient (patients who have perhaps suffered a stroke and have a
decreased ability to understand what others are saying and to express themselves):
Do not shout
Avoid complex conversations
Be patient
Help patient select words by offering a few choices
Talk to caregiver.
Tips for interacting with the caregiver:
Provide written information for the patient

Follow up by telephone (if possible) with the patient.
Evaluate Yourself
We can all improve our communication skills. There are some easy ways to evaluate your effectiveness. Try
audio or video recording some patient interactions (with permission of course). You may find that you sound
different and say things that are different from what you thought you said. Look for nonverbal cues in others:
what do you like? what do you dislike? Think about the nonverbal cues that you send. Have a student or
colleague watch you interact with a patient and then give you some feedback. Think about the patient: was
he or she relaxed and open during your discussion? did you check for patient understanding? how did you
do?
Suggested Readings
Kimberlin CL, Tindall WN. Communication skills in pharmacy practice: a practical guide for students and
practitioners. 6th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2011.
National Association of Pharmacy Regulatory Authorities. Professional competencies for Canadian

pharmacists at entry to practice. 2nd rev. Ottawa: NAPRA; 2007. Available from:
napra.ca/Content_Files/Files/Entry_to_Practice_Competencies_March2007_final_new_layout_2009.pdf.
Rantucci MJ. Pharmacists talking with patients: a guide to patient counseling. 2nd ed. Philadelphia: Lippincott
Williams & Wilkins; 2007.
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by
patients. Once printed there is no quarantee the information is up-to-date. [Printed on: 07-25-2017 09:15 AM]
RxTx, Compendium of Therapeutics for Minor Ailments © Canadian Pharmacists Association, 2017. All rights reserved
Facilitating Behaviour Change
Lisa Dolovich, BSc Phm, PharmD, MSc

Introduction
Changing behaviour is the culmination of a complex set of thoughts, beliefs, motivations and actions.
Maintaining a new behaviour over time requires continued motivation, engagement and interest. Individuals
are ultimately responsible for their own health. Healthcare practitioners cannot dictate behaviour; they can
only help facilitate positive behaviours that would improve a person's health and well-being.
Effectively managing a medical condition almost always requires some type of short- or long-term behaviour
change. This change could be to adhere to a medication regimen, exercise regularly, decrease dietary fat or
salt, reduce body weight, stop smoking or monitor blood pressure or blood glucose.
It is vital that healthcare practitioners understand how to facilitate behaviour change so that people can be
as successful as possible in initiating and maintaining change. The transtheoretical model of behaviour
change is a well-accepted framework that can help healthcare practitioners understand decision making
and change. It guides practitioners in individualizing strategies based on the patient, and explains that it
takes varying amounts of time for patients to move through stages of change—a process that can continue
throughout life.
Motivational interviewing, a directive counselling technique, can be used to help foster behaviour change.
The transtheoretical model of behaviour change can help identify patient's specific stage of change, then
motivational interviewing can be used to help move them from one stage to another.1
The Transtheoretical Model of Behaviour Change

The transtheoretical model of behaviour change is based on an extensive review of leading theories of
psychotherapy and behaviour change.2,3,4 It is called “transtheoretical” because it integrates many major
theories of intervention in the psychotherapy and behaviour-change fields.
The model is an integrative framework for understanding how individuals and populations move towards
initiating and maintaining health behaviour change. It deals with intentional behaviour change, i.e., when
individuals intend to change their own behaviour or others intend to help them change.5 It has been tested in
multiple studies, mainly in patients who had problem behaviours such as smoking, poor diet and lack of
exercise.
This theory encompasses and integrates 5 core components:
1. Stages of change
2. Processes of change
3. Decisional balance
4. Self-efficacy
5. Temptation
The best chance for successful movement through the stages of change incorporates aspects from all of
these core constructs.
Stages of Change
There are 6 stages of change: precontemplation, contemplation, preparation, action, maintenance and
termination (Figure 1).4
Precontemplation
People who are in this stage of change are not intending to change their behaviour in the foreseeable
future (within the next 6 months). They are generally uninformed or underinformed about the
consequences of their current behaviour.4 They may be reluctant or resistant to change. They may
have tried to change but became discouraged because they did not succeed.4
a,2,3,4
Figure 1: The Transtheoretical Model of Behaviour Change
a The figure shows the stages of change (e.g., Action) in bold from left to right, the 10 processes of change
(see Table 1) that can support individuals to varying degrees at each stage of change, and how pros and cons,
self-efficacy (confidence) and temptations manifest across each of the stages of change.
Abbreviations: Cons = disadvantages; Pros = benefits
Contemplation
People in this stage are intending to change, at least within the next 6 months.4 They are aware that
there is a need for change and are open to information and education. They recognize the benefits
(pros) of changing but are also very much aware of the disadvantages (cons). These opposing
beliefs can prevent someone from moving on to the next stage. People in this stage are generally not
ready for traditional action-oriented programs.4
Preparation
People who are in this stage are intending to take action in the immediate future (in the next month).4
They are beginning to set goals and prepare emotionally for change. They are the most open to
change.
Action
People in this stage of change have actually engaged in new behaviours within the past 6 months.4
They are carrying out plans, dealing with negative forces and developing a fledgling confidence in
their ability to continue with their new behaviour. But they may also experience guilt, failure and limits
to personal freedom.6 Since a person's action is observable, the overall concept of behaviour change
has often been equated with action, so it is useful to recognize that the action stage is only 1 of the 6
stages of change.4
Maintenance
People in the maintenance stage have been engaged in the new behaviour for at least 6 months.
They are working to prevent relapse. This stage can last anywhere from 6 months to 5 years.4
Termination
This stage of change includes people who have completely integrated a new behaviour into their
lifestyle.4 The new behaviour is now a usual action. They are certain they will not return to their old
behaviour.
2,4,6,7
Figure 2: Identifying the Stages of Change
a Other behaviours could be exercising regularly, decreasing dietary fat or salt, reducing body weight, stopping
smoking or monitoring blood pressure or blood glucose.
Patient Assessment to Identify Stages of Change

An assessment plan to identify what stage of change a person is in for a particular behaviour (in this
case taking medications regularly) is shown in Figure 2.
Processes of Change
The processes of change are the covert and overt actions that people use to progress through the
stages of change.4 Different processes of change should be applied at different stages to help people
move from stage to stage. This concept is an extremely useful one to consider when developing
intervention programs.4 The processes are listed, defined and matched to the stages of change in Table
1. Healthcare practitioners who recognize the need for a change to occur, and then design an
intervention to help the person go through the specific process of change, will help them achieve
success.
Table 1: Characteristics of the Processes of Change Based on the Transtheoretical Model of Behaviour
4,6
Change
Process Applicable Stages
Consciousness-raising Precontemplation and

Gaining and thinking about the causes, consequences and contemplation
cures for a particular health behaviour
Dramatic relief Precontemplation and

Experiencing or expressing feelings in response to contemplation
information about the hazards of not changing, and then
recovering from this emotional response
Environmental re-evaluation Precontemplation and

Assessing the differences in one's social environment contemplation
compared to without a particular behaviour (e.g., the effect of
smoking on others)
Self re-evaluation Contemplation

Evaluating one's attitudes and self-image compared to
without a particular behaviour
Social liberation Contemplation and preparation

Recognizing, taking advantage of and supporting social
opportunities that help others in the environment with a
similar condition to change behaviours
Self-liberation Preparation
Realizing that people are capable of successfully engaging in
healthy behaviours if they make a commitment to do so
Helping relationships Preparation, action and

The existence of meaningful others who provide support for maintenance
one's efforts to change
Reinforcement management Action and maintenance

Rewarding oneself or being rewarded by others for healthy
behaviours
Process Applicable Stages
Counterconditioning Action and maintenance

Developing and engaging in new behaviours to substitute for
old, unhealthy ones
Stimulus control Action and maintenance

Removing cues that trigger relapses in behaviours and
adding cues to facilitate healthy ones
Table 2: Steps to Facilitate Behaviour Change

1. Complete an initial general patient assessment (medical and medication histories).
2. Identify at-risk behaviours.
3. Identify stages of change for each behaviour (Figure 1).
4. Determine priorities for change (focus on only one issue at a time).
5. Ensure these priorities are consistent with urgent health needs based on health
consequences.
6. Complete a focused patient assessment for the targeted behaviour, including the patient's
particular history, personal circumstances and personality.
7. Create appropriate strategies that are matched to patients' stage of change and their
individual circumstances.
8. Monitor progress to facilitate movement through stages, respond to relapses and
determine whether the termination stage occurs.
Decisional Balance
Decisional balance encompasses the weighing of the pros and cons of behaviour change by an
individual who is thinking about changing. When lists of pros and cons generated by participants in
studies were assessed, it was found that the cons of changing were higher than the pros for people in
precontemplation stage, and the pros were higher than the cons for people in the action stage.2 It has
also been shown that the pros must increase twice as much as the cons decrease for a person to move
from precontemplation to action.8 Therefore, a healthcare professional doing a patient assessment
should recognize what a person's decisional balance is likely to be (depending on their stage of change)
to help determine whether the predicted balance of a person's particular pros and cons has been
detected. Interventions need to target reducing cons or increasing pros accordingly.
Self-efficacy
Self-efficacy is the situation-specific confidence that people have about their ability to cope with high-risk
situations without relapsing to their unhealthy or high-risk habit.4,9 The cognitive beliefs people have
about their self-efficacy influence their activities, motivations, persistence, thought patterns and
emotional responses to difficult situations.9,10,11 Self-efficacy is low in the initial stage of change and
progressively increases as people move through the stages.
Temptation
Temptation is the intensity of urges to engage in a specific habit when in the midst of difficult situations.
Common tempting situations that can create difficulties in undertaking or maintaining behaviour change
include positive social situations, emotional distress and cravings.4
4,6
Table 3: Stages of Change and Healthcare Professional Assessment and Strategies for Intervention
Sample Questions
about Taking Strategies to Facilitate
Stage Characteristics Medications Behaviour Change
Precontemplation Not intending to “What do you see Educate to raise their

change within next are the benefits of consciousness.
6 months; taking Create some
discouraged, medications?” uncertainty so people
uninformed, “What have people begin to question
underinformed, has said to you about whether their current
not tried anything; your medical behaviour patterns
cons outweighs condition?” are the best ones.
pros; low self-
efficacy; “Would you like to Provide personalized
temptations are read more about the information regarding
high benefits?” benefits and risks.
“What pressures do Give information
you have to take about helpful services
medications?” available when
patients are ready.
“What kind of help
could you get to Identify barriers to
help you take your change (e.g., what
medications?” knowledge gaps or
errors exist, what
environmental or
social issues exist?).
Focus on increasing
awareness of the
pros of changing.
Do not cheerlead, use
persuasive strategies,
be argumentative,
suggest or expect
change or let
information overload
occur.
Do not use action-
oriented strategies.
Sample Questions
Contemplation Intending to try “What is difficult Help them accept

something within 6 about taking your ownership of the
months; open to medications? How problem.
information, can I help?” Help identify
education; slightly “Who would help advantages and try to
higher self-efficacy you to take your soften the effect of
than medications?” the disadvantages.
precontemplation
stage; temptations “How would taking Use a pros vs. cons
are high; pros and your medications approach and try to
cons are about help your health?” eliminate cons (e.g.,
equal money, memory aids).
“What is one small
thing you could do Identify barriers and
to help you take temptations (self- and
your medications?” environmental
evaluations).
Help bolster self-
confidence.
Help identify their
own and others
attitudes towards
new vs. old behaviour.
Encourage them to
talk to you again
when they are ready
to begin taking their
medications.
Do not use action-
oriented strategies.
Sample Questions
Preparation Ready to engage in “Have you decided Help them commit to

behaviour(s) in the whether you are a course of action
next month; going to start (e.g., suggest a date
beginning to set medications? When they start, tell them to
goals and get is that?” tell other people they
emotionally ready “Have you told your are starting, contract
for change; pros doctor you are going to make the change,
and cons are about to continue to take set objective and
equal, or pros are the medications?” realistic goals).
greater than cons Announce course of
“Have you thought
action to others.
about how you are
going to change Identify and involve
your schedule to supportive others in
make medication- the plan for change.
taking easier?” Provide frequent
encouragement.
Increase awareness
of social policies that
support their new
behaviour (e.g.,
smoking ban,
Canada's Food
Guide).
Engage in action-
focused education
program.
Action Actually trying to “How have you had Reinforce successes

change behaviour; to rearrange your to increase self-
improved self- life so that you can efficacy.
efficacy; pros take your Assist with stimulus
outweigh cons; medications more control (reminders,
temptations are low easily?” conduct encouraging
“Who has been follow-up calls).
helping you stick to Support their use of
your plan?” helping relationships.
“How have you been Highlight decreasing
feeling about how to the cons.
manage taking your
Recognize and
medications?”
quickly address
faltering behaviour
change (e.g., frequent
monitoring, work to
problem-solve
unanticipated issues).
Sample Questions
Maintenance Has been engaged “How is taking your Reinforcement of

in new behaviours medications going?” successes (notes,
for at least 6 “What do you think measurement of
months; working to has been the most results, updates on
prevent relapse; helpful thing you did benefits of activity).
self-efficacy is high, to achieve Assist with stimulus
temptations are success?” control (reminders,
low; taking conduct encouraging
responsibility for (Reinforce this)
follow-up calls).
actions “Have there been
Suggest additional
any difficulties with
behaviours that can
taking your
add to current
medications over
success.
the last while?”
Suggest alterations
that remove cues that
trigger relapses.
Recognize relapses
as part of process
and assist with
getting back on track.
Termination Zero temptation “How is taking your Recognize that

and 100% self- medications going?” regular healthcare
efficacy; will not professional
return to old habits facilitation is no
longer required.
Developing a Plan to Facilitate Behaviour Change

Once a person's at-risk behaviour and stage of change have been identified, a plan to facilitate a person's
behaviour change can be developed and implemented (Table 2). People do not skip stages. Instead,
success occurs when there is movement along the continuum of change.5 Few people are in the preparation
stage for more than one behaviour at a time, so it is more helpful to identify the highest-priority issue and
work only on this behaviour. A study examining those who have at-risk behaviours (e.g., smokers) found the
distribution to be the following: precontemplation (40%), contemplation (40%) and preparation (20%).4 A
group of patients with arthritis who were assessed for their willingness to adopt self-management
strategies included 44% of people in the precontemplation stage and 11% of people in the contemplation
stage.12 Given that most people are not in the preparation or action stage for many at-risk behaviours, those
who are intending to change will not be helped by conventional action-oriented approaches. Various
strategies specific to each stage of change are provided in Table 3.
Motivational Interviewing
Motivational interviewing (MI) is a patient-centred approach that is used to determine a patient's readiness
to engage in a target behaviour such as taking a prescribed medication. The approach aims to respect the
patient's autonomy and help patient decision making. In doing so, MI also helps develop a better
relationship with the patient.13 MI is a directive, client-centred counselling style used to bring about
behaviour change by helping patients explore and resolve ambivalence.14 It is not intended to be persuasive
but instead aims to help patients understand their diagnosis as well as the risks and benefits of a course of
action, and focuses the healthcare practitioner on the specifics of what is motivating patients not to follow a
course of action.
The MI approach can be used to help a patient move from one stage of behaviour to another. The MI
approach is a counselling style, not a treatment. It is more goal-directed and focused than nondirective
counselling.14,15 The characteristics of MI are summarized as follows:16
Motivation to change is elicited from the client, and not imposed from without
It is the client's task, not the counsellor's, to articulate and resolve his or her ambivalence
Direct persuasion is not an effective method for resolving ambivalence
The counselling style is generally a quiet and eliciting one
The counsellor is directive in helping the client to examine and resolve ambivalence
Readiness to change is not a client trait but a fluctuating product of interpersonal interaction
The therapeutic relationship is more like a partnership or companionship than expert/recipient roles.
In MI, 5 principles are used along with a menu of strategies to assess how ready patients are to change their
behaviour and to focus on their ambivalence and resistance.13 Strategies focus on:
Eliciting information from patients to understand their typical day and lifestyle, their perspective on
their medical condition and treatments and the barriers to change
Providing information based on their situation or concerns
Eliciting further concerns and helping with decision making.
The combined first letters of each of the 5 principles form the acronym READS: roll with resistance, express
empathy, avoid argumentation, develop discrepancies and support self-efficacy.13
An example of conventional paternalistic dialogue when talking to a female patient about taking ASA daily to
prevent cardiovascular complications could be as follows: “If you do not take this medication, your risk of
stroke increases by about 17%”.17 In contrast an MI based dialogue might include questions such as: “How
important is reducing your risk of future heart disease or strokes?” and “What benefits do you think you
might get from taking this drug?”.
In a meta-analytic review, Rubak et al. found that the evoking style of MI outperformed advice giving in
approximately 80% of randomized controlled trials and was not more time-consuming.16 This was in a
broad range of areas, including obesity, cholesterol and hypertension control. Healthcare practitioners in any
setting can use this approach when patients may be hesitant about a behaviour change or treatment
because it is a style instead of a specific and formal technique. Pharmacists report MI techniques are more
successful in an environment and workflow that allowed for longer conversations with patients at times
when fewer patients are in the store.18 Evidence suggests that telephone-based motivational interviewing or
combining interviewing with cognitive behavioural interventions may also be associated with improved
medication adherence.19,20
Conclusions
Changing behaviour is often difficult. Healthcare practitioners have an essential role in providing education
and guidance for patients at risk of unfavourable health outcomes. The transtheoretical model of behaviour
change can be used to identify a patient's specific stage of change. Motivational interviewing can be
employed to help a patient move from one stage to another stage to promote constructive behaviour
change.
Resource Tips
Motivational Interviewing Network of Trainers (resources for clinicians, supervisors, program managers and
trainers). Available from: www.motivationalinterviewing.org.
Suggested Readings
Berger BA, Hudmon KS. Readiness for change: implications for patient care. J Am Pharm Assoc (Wash)
1997;NS37:321-9.
Prochaska JO, Johnson S, Lee P. The transtheoretical model of behavior change. In: Shumacker SA et al.,
eds. The handbook of health behavior change. 3rd ed. New York: Springer Publishing Company; 2009. p. 59-
84.
Rollnick S, Miller WR. What is motivational interviewing? Behav Cogn Psychother 1995;23:325-34.
Soderlund LL, Nilsen P. Feasibility of using motivational interviewing in a Swedish pharmacy setting. Int J
Pharm Pract 2009;17:143-9.
References
1. Erol S, Erdogan S. Application of a stage based motivational interviewing approach to adolescent

smoking cessation: the Transtheoretical Model-based study. Patient Educ Couns 2008;72:42-8.
2. Prochaska JO, Velicer WF, Rossi JS et al. Stages of change and decisional balance for 12 problem
behaviors. Health Psychol 1994;13:39-46.
3. Prochaska JO, DiClemente CC. Transtheoretical therapy: toward a more integrative model of change.
Psychother Theory Res Pract 1982;19:276-88.
4. Prochaska JO, Johnson S, Lee P. The transtheoretical model of behavior change. In: Shumacker SA
et al., eds. The handbook of health behavior change. 3rd ed. New York: Springer Publishing Company;
2009. p. 59-84.
5. Prochaska JO, DiClemente CC, Velicer WF et al. Criticisms and concerns of the transtheoretical
model in light of recent research. Br J Addict 1992;87:825-8.
6. Berger BA, Hudmon KS. Readiness for change: implications for patient care. J Am Pharm Assoc
(Wash) 1997;NS37:321-9.
7. Jones H, Edwards L, Belton A et al. Helping people with diabetes change. Lifescan Education Institute
1998:1-29.
8. Prochaska JO. Strong and weak principles for progressing from precontemplation to action on the
basis of twelve problem behaviors. Health Psychol 1994;13:47-51.
9. Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev 1977;84:191-
215.
10. Bandura A. Human agency in social cognitive theory. Am Psychol 1989;44:1175-84.
11. Bandura A. Social foundations of thought and action. Englewood Cliffs: Prentice Hall; 1986.
12. Keefe FJ, Lefebvre JC, Kerns RD et al. Understanding the adoption of arthritis self-management:
stages of change profiles among arthritis patients. Pain 2000;87:303-13.
13. Villaume WA, Berger BA, Barker BN. Learning motivational interviewing: scripting a virtual patient.
Am J Pharm Educ 2006;70:33.
14. Rollnick S, Miller WR. What is motivational interviewing? Behav Cogn Psychother 1995;23:325-34.
15. Miller WR, Rollnick S. Motivational interviewing: preparing people for change. New York: Guilford
Press; 1991.
16. Rubak S, Sandbaek A, Lauritzen T et al. Motivational interviewing: a systematic review and meta-
analysis. Br J Gen Pract 2005;55:305-12.
17. U.S. Preventive Services Task Force. Aspirin for the prevention of cardiovascular disease: U.S.
Preventive Services Task Force recommendation statement. Ann Intern Med 2009;150:396-404.
18. Soderlund LL, Nilsen P. Feasibility of using motivational interviewing in a Swedish pharmacy setting.
Int J Pharm Pract 2009;17:143-9.
19. Teeter BS, Kavookjian J. Telephone-based motivational interviewing for medication adherence: a
systematic review. Transl Behav Med 2014;4:372-81.
20. Spoelstra SL, Schueller M, Hilton M et al. Interventions combining motivational interviewing and
cognitive behaviour to promote medication adherence: a literature review. J Clin Nurs 2015;24:1163-
73.
Pharmacist Assessment of the Self-treating Patient
Nardine Nakhla, PharmD

CPhA acknowledges the contribution of J. D. Barry Power as a previous author of this chapter.
Introduction
Nonprescription medications are readily available in many retail outlets and commonly self-selected by the
public. Consultation with a pharmacist will ensure that self-treatment is both safe and effective. To help
meet these goals, pharmacists must accurately determine the seriousness of the condition for which
treatment is being sought, determine how the condition should be managed, and then assist with selection
of suitable pharmacologic and nonpharmacologic therapies within their scope of practice. Systematic
patient assessment and triage can help the busy pharmacist do this quickly and effectively.
Problem Solving Process

Advising patients on self-care activities carries great professional responsibility.1 Patients requiring self-care
may not have been assessed by or received any treatment from another healthcare practitioner. In addition
to gathering patient information (including obtaining laboratory or diagnostic measurements) and, if needed,
performing a physical exam (mainly inspection and palpation), pharmacists must assist patients in
determining when and how to treat their condition(s), or when to access emergency services or seek care
from another healthcare practitioner. Before making any recommendations, a thorough assessment is
required to identify patients who require additional care or who have special needs that might influence
product selection.
To determine which recommendation is most appropriate for a patient, the pharmacist must complete the
following problem-solving steps:
1. Collect patient-specific information relative to each health problem/chief complaint/symptom

2. Perform assessment and triage
3. Create, implement, and counsel on a care plan
4. Evaluate the results of the care plan and make adjustments when the patient outcome is less than
optimal.
A systematic approach to determining patients’ self-care needs will result in consistent and comprehensive
patient assessment, and lead to optimal therapeutic outcomes2 (Figure 1). Several mnemonics have been
developed to assist pharmacists in standardizing their approach to information gathering, patient
assessment and triage. Two useful mnemonics are presented in Table 1. Evidence shows that the use of a
structured interviewing framework improves user confidence, recommendations and counselling.6 Also,
patient assessment is more comprehensive and there is less opportunity for error.
1,3,4,,5
Table 1: Mnemonics to Assist with Information Gathering and Standardized Patient Assessment
Mnemonic Interpretation
WWHAM Who is the medicine for?

What is the medicine for?
How long have the symptoms been present?
Action(s) already taken?
Medicines taken for other reasons, prescribed or otherwise?
Mnemonic Interpretation
QuEST SCHOLAR MAC(S) Quickly and accurately assess the patient using SCHOLAR
MAC(S)a
Symptoms-main and associated symptoms
Characteristics-what is the situation like? Is it
changing?
History-what has been done so far?
Onset-when did it start?
Location-where is the problem?
Aggrevating factors-what makes it worse?
Remitting factors-what makes it better?
MAC(S): Ask about other Medications, Allergies,
Conditions, Social historya
Establish self-care appropriateness
Suggest care
Talk to patient
a
S for social history is not part of the original published algorithm,5 but was added by the author.
Step 1: Collecting Patient Information
Determine why the patient is seeking help or looking for a nonprescription product.
Ask the patient to explain the condition(s), symptom(s) or problem(s) they wish to treat.
Enquire about the patient's history. The MAC(S) acronym (Table 1) is specific to an individual’s
medical history and is intended to prompt users to collect additional pieces of key patient
information. If relevant, ask women about the possibility that they might be pregnant or planning a
pregnancy.
Perform physical assessment when appropriate. For example, a pharmacist may need to inspect a
rash to be able to make an appropriate recommendation. Some patients may not be able to explain
what their condition looks like, but may be able to show it. Warts, athlete’s foot and minor cuts and
burns are easily inspected.
Step 2: Patient Assessment and Triage
This step involves the assessment of the information gathered in Step 1 to identify the patient’s problem,
its severity, urgency and its most probable cause.1 Clear articulation of the problem is critical to assist
with differentiation among conditions with similar symptoms and to determine the goals of self-
treatment. This is followed by triage to determine the most appropriate action:
Referring to another healthcare practitioner

Recommending self-care (nonpharmacologic or pharmacologic therapy)
Recommending self-care until patient can see another healthcare practitioner
Reassuring patient that no treatment is necessary at this time.
Patient-specific data should be assessed to identify exclusions for self-treatment. It may not be
appropriate for an individual to self-treat for several reasons (see Table 2). To establish that the patient is
an appropriate self-care candidate ask if the patient:
has any severe symptoms?

has any symptoms that persist or return repeatedly?
is self-treating to avoid medical care?
A patient meeting any of these criteria is referred for further medical evaluation,6,7 since most medical
conditions that can be safely self-treated are characterized as having no severe symptoms, and no
symptoms that are persistent or repeatedly return without an identifiable cause. Additionally, patients
should not self-treat in an attempt to avoid evaluation and treatment by a healthcare practitioner.
a
Table 2: Red Flags Warranting Referral for More Intensive/Urgent Care
Red Flag Possible Significance of Red Flag
Change in level of consciousness, change in Infection, concussion, stroke, hypoglycemia,

senses (vision, hearing, taste), seizures or poisoning or overdose
difficulty breathing
Paralysis of face, arms, legs; difficulty speaking Transient ischemic attack, stroke
Severe headache (“Worst headache I’ve ever Cerebral aneurysm or stroke

had.”)
Fever in infants <6 months Infection, meningitis
Fever in those >6 months for >72 hours Infection
Fever, vomiting, headache, confusion, difficulty Meningitis

bending neck
Diarrhea or vomiting in high-risk groups (e.g., Risk of dehydration. More intensive

infants, children, elderly) investigation may be required
Persistent bleeding Clotting abnormalities
Spontaneous bleeding/bruising Clotting abnormalities
Bleeding from any orifice Internal bleeding
Discolored urine or feces (rule out drug causes) Internal bleeding
Chest pain Acute coronary syndromes
Increasing breathlessness Pulmonary embolism, heart failure,

bronchospasm
Partial- or full-thickness burns to the face or May cause airway obstruction

mouth
Localized redness, swelling, tenderness, heat or Infection

pus
Yellowing of skin and/or eyes Jaundice or liver damage
a Other signs or symptoms may suggest less urgent referral for further investigation. Consult the relevant chapter
for the body system involved e.g., Assessment of Patients with Eye Conditions.
Poisoning
Management of the patient who may have been accidentally or intentionally exposed to a poison
requires a specific type of assessment and triage. Suggested management is shown in Figure 2. The
likelihood of accidental poisoning is highest with children, especially between 1 and 3 years of age.8
Common sources of poisoning in children are nonprescription medicines (cough and cold,
analgesics), plants and cleaning agents. Determining the source of the poison, if possible, can be
helpful in management.
Step 3: Create, Implement and Counsel on a Care Plan
If self-treatment is deemed appropriate, the pharmacist can provide the patient with suitable products
and provide education about relevant nonpharmacologic and preventive measures. Establishing patient
goals and educating on realistic timeframes for outcomes is imperative and should be discussed first. It
is also important to involve the patient in the decision-making process for product selection. Then clearly
communicate the therapeutic plan: provide an explanation of the condition, treatment recommendations
and rationale.1 In some provinces the pharmacist care plan may be part of a recognized minor ailments
prescribing program which may include a specified range of treatment options.
1. Establish the patient’s goals:

Discuss and set realistic goals for therapy and realistic timelines for therapeutic outcomes.
For example, “curing” a cold is not possible, but relief of symptoms is.
2. Involve the patient in the decision making process:
Provide patient with a choice of products if possible
When possible tailor the product selection to meet the patient's expectations
Provide additional information resources.
3. Select product and counsel:
Determine appropriate product(s) for the condition on the basis of patient- or therapy-specific
variables1
Educate the patient on proper use, adverse effects and onset of action of each treatment
selected
Advise the patient about what to expect from the treatment and what actions to take if
symptoms do not resolve within the expected timeframe
Where applicable, the plan should include lifestyle changes and nonpharmacologic prevention
and treatment measures.
Step 4: Evaluation and Follow Up
Provide guidelines for follow up if necessary and encourage the patient to call or return if
symptoms fail to resolve (e.g., “If your fever does not go away in 3 days, or if your temperature
exceeds 40.5°C, contact your doctor.”).
For some cases, follow up is vital. For example, parents seeking a rehydration fluid for their child
should be contacted within 24 hours to determine whether the child is displaying signs of
dehydration.
Follow up may not be possible in many cases.
Use professional judgment in determining cases for follow up.
Documentation will allow for more effective follow up and continuity of care.
Algorithms
Figure 1: Self-care Problem-solving Process

Figure 2: Triage of the Poisoned Patient
Suggested Readings
Dolovich L, Hudson A. Collecting the evidence. Pharm Pract 1997;13:68-77.
Jones RM Patient assessment in pharmacy practice. 3rd ed. Philadelphia: Wolters Kluwer; 2016.
Longe RL, Calvert JC, Young LY. Physical assessment: a guide for evaluating drug therapy. Vancouver: Applied
Therapeutics; 1994.
Stein SM. BOH’s pharmacy practice manual: a guide to the clinical experience. 4th ed. Philadelphia: Wolters
Kluwer Health/Lippincott Williams & Wilkins; 2015.
References
1. Newton GD, Divine H. Patient assessment and consultation. In: Handbook of nonprescription drugs.
18th ed. Washington: American Pharmacists Association; 2015. p. 17-31.
2. Dinkins M. Patient counseling: a pharmacist in every OTC aisle. US Pharm 2010;35:9-12.
3. Addison B, Brown A, Edwards R et al. Minor illness or major disease? 5th ed. London: Pharmaceutical
Press; 2012.
4. Rodgers R. PJ practice checklist: sale of medicines protocols. Pharm J 1996;178:34-6.
5. Leibowitz K, Ginsburg D. Counseling self-treating patients quickly and effectively. Proceedings of the
APhA Inaugural Self-Care Institute; 2002 May 17-19; Chantilly, VA.
6. Buring SM, Kirby J, Conrad WF. A structured approach for teaching students to counsel self-care
patients. Am J Pharm Educ 2007;71:8.
7. Jones R, Charlton J, Latinovic R et al. Alarm symptoms and identification of non-cancer diagnoses in
primary care: cohort study. BMJ 2009;339:b3094.
8. British Columbia Drug and Poison Information Centre. Fact sheet. Vancouver: BC DPIC. Available
from: dpic.org/bc-dpic-fact-sheets/british-columbia-poison-control-centre-fact-sheet.
Depression
Ric M. Procyshyn, PharmD, PhD

Alasdair M. Barr, PhD
Introduction
Even in its mildest form, depression is not a minor ailment. It is included in this compendium of conditions
to support the continuum of care for patients, whether initially presenting with symptoms of depression or
being followed by one or more healthcare practitioners at any stage of the disease. More detailed
information regarding treatment of depression is available in the Compendium of Therapeutic Choices:
Depression.
Pathophysiology
Although the exact mechanism underlying the etiology of depression is unknown, it is understood to be the
result of complex interactions involving monoamine neurotransmitter function, gene products such as brain-
derived neurotrophic factor (BDNF) that enhance postsynaptic neuronal function and other biological factors
including neuroendocrine and neuroimmune regulation, sleep abnormalities and aberrant neuronal circuits.1
The signs and symptoms of depressive disorders described in DSM-5 are presented in Table 1.2 It is
important to recognize that an estimated one-third of patients who present with depressive symptoms may
be experiencing depression in the context of bipolar disorder and will require a different treatment plan from
those with primary depression.3 Patients presenting with depression should be asked if there have been
manic or hypomanic episodes in their past.
Depression that occurs in association with other medical conditions can negatively affect the prognosis of
these conditions and the patient's adherence to treatment. For example, depression exhibits a bidirectional
association with cardiovascular disease and can lead to poorer cardiovascular outcomes.4,5 When
assessing patients for depression, investigate for any association with other medical conditions.
Many medications (e.g., beta-blockers, corticosteroids, oral contraceptives) have been implicated in the
etiology of depression, though good quality evidence of a causal link is often lacking. Nonetheless, in the
differential diagnosis of depression, consider the patient's medication profile and make any adjustments
that seem reasonable and appropriate.
Prevalence
Depressive disorders are common, with an annual and lifetime prevalence in Canada of 4% and 11%
respectively.6 The risk of major depressive disorder (MDD) is 1.5–3 times greater among those who have
a first-degree relative with depression. The risk of recurrence in an individual who has experienced 1
previous major depressive episode is 60%; this risk increases to 70% following 2 episodes and 90% after
3. Depression is a leading cause of disability worldwide with significant impact on occupational
functioning and quality of life.7
Goals of Therapy
Relieve symptoms of depression
Prevent suicide
Return to optimal levels of psychosocial functioning
Prevent relapse and recurrence
Patient Assessment
Clinical features of depressive disorders are presented in Table 1. Screening for depression can help to
identify patients who would benefit from further assessment and, when indicated, appropriate treatment.
The Patient Health Questionnaire-9 (PHQ-9)8 is a 9-item depression module from a general health screening
tool used in primary care assessments. A quick and effective tool to identify patients who may require
further assessment is to ask the first 2 questions from the PHQ-9 (also referred to as the PHQ-2).9,10
Patients should undergo further assessment if they answer “yes” to either of following PHQ-2 questions:
1. Over the past 2 weeks, have you been bothered by feeling down, depressed or hopeless nearly every
day?
2. Over the past 2 weeks, have you had little interest or pleasure in doing things nearly every day?
The Edinburgh Postnatal Depression Scale is a useful screening tool for detecting postpartum depression.11
Patient information on postpartum depression is included in Prenatal and Postpartum Care.
2
Table 1: Clinical Features of Depressive Disorders
Disorder Diagnostic Features a,b

Major Depressive History of one or more major depressive episodes, with 5 or more of the
Disorder (MDD) following symptoms on most days for at least 2 weeks (at least 1 of the
first 2 must be present):
1. Depressed mood
2. Markedly decreased interest or pleasure
3. Significant weight loss or gain
4. Insomnia or hypersomnia
5. Agitation/restlessness or lethargy
6. Fatigue or loss of energy
7. Feelings of worthlessness or excessive guilt
8. Decreased ability to think, concentrate, make decisions
9. Suicidal thoughts, plans or actions
Persistent Characterized by depressed mood for most of the day, more days than not,
Depressive Disorder for at least 2 years, plus at least 2 of the following:
(Dysthymia) 1. Poor appetite or overeating
2. Insomnia or hypersomnia
3. Low energy or fatigue
4. Low self-esteem
5. Poor concentration or decision-making ability
6. Feelings of hopelessness
Note: In children and adolescents, mood can be irritable and the duration
must be at least 1 year.
Other Depressive Disruptive mood dysregulation disorder

Disorders listed in Premenstrual dysphoric disorder
DSM-5
Substance/medication-induced depressive disorder
Depressive disorder due to another medical condition
Other specified depressive disorder
Unspecified depressive disorder
a Not due to medically or drug-induced conditions or normal bereavement.
b Symptoms must be associated with impairment in social, occupational or other areas of functioning.
Nonpharmacologic Therapy
Psychotherapy involves the use of communication based on a psychological model of illness. Of the many
different types, cognitive behavioural therapy (CBT) and interpersonal therapy (IPT) are the most studied and
widely recommended forms.12 Psychotherapy has traditionally involved a relationship between a patient and
therapist but has evolved to include patient-managed psychotherapy options such as bibliotherapy (e.g.,
self-help books) and Internet-delivered CBT.13 For depression, the combination of psychotherapy and
pharmacotherapy has been shown to be superior to either modality alone, especially with respect to relapse
prevention. Psychotherapy alone may be effective, particularly in mild-to-moderate depression, but is not
recommended for suicidal patients or those with psychotic features.12 Exercise as an adjunctive measure
can be effective in ameliorating symptoms of depression14,15 and should be encouraged because of its
general health benefits. Patients may gain insight and learn useful strategies to self-manage their
depressive symptoms from many resources available on the Internet (see Resource Tips).
Light therapy is considered a first-line option for seasonal MDD (seasonal affective disorder; “SAD”) or as an
adjunctive measure for nonseasonal MDD of mild to moderate severity.14 A randomized controlled study
showed that light therapy, both as monotherapy and in combination with fluoxetine, was effective and well
tolerated in the treatment of adults with nonseasonal MDD; the combination treatment had the most
consistent effects.16 Patients are exposed to a 10 000-lux intensity light box slanted toward the face for 30
minutes per day, preferably in the early morning. Improvement in depressive symptoms usually occurs within
1–3 weeks. Adverse effects (e.g., headache, eye strain, irritability, insomnia) are usually mild and do not
cause patients to discontinue light therapy. To minimize side effects, patients may begin with 10–15
minutes per day and gradually increase exposure to 30 minutes. Patients with eye conditions that make
them more vulnerable to light should check with their eye care practitioner before beginning light therapy.
Light boxes with UV filters are recommended.
Electroconvulsive therapy (ECT), a treatment that involves the electrical induction of seizures in an
anesthetized patient, has the highest rate of response of any form of antidepressant therapy. It is generally
reserved for use in patients with severe symptoms and functional impairment, comorbid psychotic
symptoms or catatonia, acute suicidal ideation or treatment-resistant depression.17 In a study designed to
predict nonresponse to ECT in a cohort of patients with major depression who were resistant to
pharmacologic treatment, a lack of response was associated with bipolar subtype, the presence of manic
symptoms during depression, slightly less severe depressive symptomatology and protracted duration of the
depressive episode.18
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique used in conscious patients.
An electrical current is passed through a coil on the surface of the head to deliver a magnetic field through
the skull to the brain, where it stimulates neuronal function. Though response rates are generally lower than
with ECT, rTMS is considered to be a safe and well-tolerated option for patients who do not respond to initial
treatment.17 Although further studies are needed to determine the optimal duration of treatment and
predictors of treatment response, a meta-analysis found rTMS to be an effective and safe technique for the
treatment of medication-refractory depression.19
Pharmacologic Therapy
Pharmacotherapy combined with psychotherapy is recognized as having better efficacy in the treatment of
depression than either modality alone. For an in-depth review of drug therapy for depression, consult the
Compendium of Therapeutic Choices: Depression.
Antidepressants
First-, second- and third-line agents listed in the 2009 CANMAT guidelines are included in Table 2.20
Between drug classes and within drug classes, the clinical effectiveness of antidepressants is generally
comparable. When initiating therapy, select an antidepressant after considering the patient's
concomitant medical problems, their response to any prior antidepressant and the drug's side effect
profile, potential drug interactions and cost.20
Some general principles of antidepressant therapy include:20
Many antidepressants can be used as first-line agents (Table 2).20 Choice of therapy may be based
on individual patient characteristics (comorbidities, concomitant medications, previous response to
antidepressant, preference)
Although clinical lore states that antidepressants take 2–4 weeks (or longer) to exert their
therapeutic effects, meta-analyses have concluded that antidepressants begin to exhibit a
beneficial effect within 1–2 weeks of initiation21,22
When patients are starting or switching to a new antidepressant, monitor for response to treatment,
adverse effects and improvement in target symptoms (Table 3)
An antidepressant is considered effective if there is >20% improvement in depressive symptoms
using a depression rating scale
If there is little improvement after 2 weeks of antidepressant therapy, consider a change in
treatment strategy, such as increasing the dose20
If there is improvement, e.g., within 6 weeks, continue the antidepressant for another 2–4 weeks
before considering a change in treatment strategy20
Advise patients not to stop taking antidepressants suddenly as this can cause a withdrawal
syndrome. Symptoms might include headache, dizziness, nausea, diarrhea, insomnia, mood lability,
electric “shock-like” sensations, vivid dreams/nightmares. To prevent withdrawal symptoms, taper
antidepressant doses gradually by 25% per week and monitor for a re-emergence of depressive
symptoms.26
20
Table 2: CANMAT Classification of Antidepressants
Classification Antidepressants
First-line agentsa bupropion

mirtazapine
moclobemide
SNRIs (desvenlafaxine, duloxetine, venlafaxine)
SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine,
paroxetine, sertraline)
Second-line agentsa quetiapine

trazodone
tricyclic antidepressants
Third-line agentsa irreversible MAOIs (phenelzine, tranylcypromine)
a Within each category, antidepressants are listed in alphabetical order rather than order of preference.
Abbreviations: MAOI = monoamine oxidase inhibitor; SNRI = serotonin norepinephrine reuptake inhibitor; SSRI
= selective serotonin reuptake inhibitor
Duration of Antidepressant Therapy

There is no clear consensus on the recommended duration of antidepressant therapy. Factors to
consider include the duration and severity of the current episode as well as the number of previous
depressive episodes. Clinical guidelines recommend maintaining antidepressant therapy for at least
6–9 months after remission of symptoms in patients experiencing a first episode of depression.20
The guidelines are less clear for patients with a history of multiple episodes or inadequate treatment
response. Since these individuals are at a greater risk of a recurrence, treatment with an
antidepressant longer than 1 year after remission of symptoms is not unreasonable.
Natural Health Products
It is estimated that more than half of patients with MDD will have used one or more complementary and
alternative medicines in the last year, with or without the knowledge of their healthcare provider.
Healthcare practitioners should routinely ask patients about their use of natural health products and
provide guidance about the risks and benefits of these agents. Patients should know that these
treatments do not normally replace standard medications for MDD. While better quality research is
needed to evaluate the effect of natural health products on psychiatric illness, limited evidence has
shown that some of these agents may be beneficial for patients with depression or for overall health.
Some natural health products should not be combined with antidepressants. When patients are taking
natural health products, carefully monitor for potential drug interactions. Several natural health products
(Table 4) have shown some benefit in the treatment of depression.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor
Ailments—Herbal and Natural Health Products: Single Entity.
Monotherapy with St. John's wort is considered a potential first-line option for MDD of mild to moderate
severity based on several studies and systematic reviews.14,30,31,32,33 As an inducer of CYP3A4 and
intestinal P-glycoprotein, St. John's wort can decrease the effectiveness of many medications by
increasing their metabolism and reducing their systemic bioavailability.34 Combined therapy with other
serotonergic medications (particularly MAO inhibitors) is associated with an increased risk of serotonin
syndrome, a potentially fatal reaction characterized by mental status changes, agitation and tremor,
potentially progressing to malignant hyperthermia, rhabdomyolysis, seizures, arrhythmias and respiratory
arrest. Evaluate potential drug interactions in patients who wish to take this herbal product.
S-adenosyl-L-methionine (SAMe), a synthetic form of a dietary amino acid, may be an effective second-
line monotherapy option for the treatment of mild to moderate depression. SAMe has also been shown
to be effective, well-tolerated and a safe adjunctive treatment for individuals showing nonresponse to
serotonin reuptake inhibitors.35 SAMe is well tolerated with few adverse effects, but may be associated
with an increased risk of serotonin syndrome when combined with other serotonergic drugs.14,27,36
Omega-3 fatty acids are often recommended as second-line therapy for the treatment of mild to
moderate depression.14,27,37 However a meta-analysis suggests that the evidence to support their use is
of low quality, and the benefits are not clinically significant.38 Since they are nutritional compounds with
established benefits for human health, including fetal and infant development, omega-3 fatty acids may
be considered as an add-on option for perinatal depression.39,40 Side effects such as fishy aftertaste,
nausea and diarrhea are usually mild.
Folate is a naturally-occurring B vitamin found in leafy green vegetables, fruits, dried beans and peas
whereas folic acid is the synthetic form of folate found in supplements and fortified foods. Evidence
suggests that folate deficiency is associated with the symptoms of depression, symptom severity and
treatment outcomes.41,42 A trial funded by the NIHR Health Technology Assessment program (UK) failed
to find evidence for the clinical- or cost-effectiveness of folic acid (5 mg po daily) as an adjunct to
antidepressant medication.43 This negative study further highlights that methylfolate, and not folic acid,
may be a better candidate for augmenting antidepressants in patients with low folate levels.
Methylfolate is not commercially available in Canada.
Vitamin D supplementation may have a beneficial effect on depression.14 In a systematic review and
meta-analysis, low serum levels of vitamin D were found to be associated with depression.44 More
randomized controlled trials with vitamin D are needed to determine whether this association is causal
and to clarify its potential role in prevention and treatment of depression.
Monitoring of Therapy
Routine monitoring of patients with depression should be performed at regular intervals during treatment. In
general, pediatric patients and those with more severe illness should be monitored more frequently (e.g.,
weekly for 4 weeks, then biweekly for 4 weeks, then at 3 months).45,46 Table 3 provides examples of
monitoring parameters that can be used by health professionals to gauge the patient's response to
depression treatment. Because antidepressants can take some time to provide full benefit, support and
education are important to help patients cope with symptoms of guilt, worthlessness, helplessness and
hopelessness. Provide patients with resources to help them understand their symptoms, their medication
and what they can do to help optimize their response to treatment and quality of life (see Resource Tips).
20
Table 3: Monitoring of Therapy for Depression
Monitoring Comments
Parameter
Target symptoms Symptoms such as anxiety, decreased appetite and insomnia usually
begin to improve within the first week of treatment. Increased energy and
libido are often seen within 1 month.
Depressive symptoms may take up to 8 wk or longer to fully respond to
antidepressant medication. Some improvement is usually seen within 3–
4 wk.
Adverse effects of Anticholinergic effects, e.g., constipation, dry mouth, urinary retention.
antidepressant therapy Cardiovascular, e.g., dizziness, hypertension, tachycardia. For patients
older than 40 y, an ECG is warranted prior to starting treatment with a
TCA.23
CNS, e.g., headaches, memory impairment, sedation, seizures.
GI, e.g., diarrhea, nausea, vomiting, weight gain.
Sexual dysfunction, e.g., anorgasmia, decreased libido,
erectile/ejaculatory dysfunction.
Withdrawal (abrupt), e.g., anxiety, confusion, crying, fever, headache,
insomnia, irritability, lethargy, nausea, sweating, vivid dreams.
Emergence of suicidal Though untreated depression is associated with a higher overall risk of
ideation suicide, increased suicidality can occur during treatment, more often in
pediatric patients and young adults. Patients should be asked about
suicidal thinking, particularly during the initial phases of treatment.
Psychometric rating Allows for rapid and reliable measurement of symptom severity.
scales, e.g., BDI-II,24
PHQ-9,8 QIDS-SR25
Interviewing family Can provide valuable information regarding depressive symptoms as well
member or friend as daily, social and occupational functioning. Patient permission should
be obtained.
Abbreviations: BDI-II = Beck Depression Inventory II; CNS = central nervous system; ECG = electrocardiogram; PHQ-9
= Patient Health Questionnaire-9; QIDS-SR = Quick Inventory of Depressive Symptomatology, Self-Rated; TCA =
tricyclic antidepressant
Drug Table
Table 4: Natural Health Products for Depression14,27,28,29
Drug/Costa Dosage Adverse Drug Interactions Comments

Effects
Drug Class: Natural Health Products
omega-3 1–2 Mild side effects Potential additive bleeding risk Insufficient
fatty acids g/day po include fishy with drugs such as ASA, evidence for
of an aftertaste, GI warfarin, other antiplatelet or against use
$ EPA-DHA upset. agents. during
mixture Risk of bleeding pregnancy or
documented breastfeeding.
(minimal with
doses less than
3 g/day).
S-adenosyl- 400– Infrequent: Avoid concurrent use with Insufficient

L- 1600 Constipation, other serotonergic drugs such evidence for
methionine mg/day dizziness, dry as antidepressants (possible or against use
po in 2–3 mouth, serotonin syndrome). during
$$$ divided insomnia (mild), pregnancy or
doses nausea, breastfeeding.
sweating.
Case reports of
increased
anxiety, mania
or hypomania in
patients with
bipolar disorder.
St. John's Usual: Agitation, Avoid concurrent use with Avoid during
wort 300 mg dizziness, MAOIs (risk of severe, pregnancy
TID po insomnia, GI potentially fatal serotonin and
$ Range: upset, syndrome). breastfeeding.
300– photosensitivity Avoid concurrent use with
1800 (rare), SSRIs or other serotonergic
mg/day, restlessness. drugs such as tricyclic
usually in Case reports of antidepressants (possible
2–3 mania or serotonin syndrome).
divided hypomania. May decrease plasma
doses concentration and
effectiveness of several drugs
including cyclosporine, digoxin,
indinavir, oral contraceptives,
theophylline, warfarin.
a Cost of 30-day supply for mean usual dose; includes drug cost only.
Abbreviations: EPA-DHA = eicosapentaenoic acid-docosahexaenoic acid; GI = gastrointestinal; MAOI = monoamine

oxidase inhibitor; SSRI = selective serotonin reuptake inhibitor
Legend: $ < $30 $$ $30–60 $$$ $60–90
Resource Tips
Canadian Network for Mood and Anxiety Treatments. Help & Resources. Depression and anxiety. Available
from: www.canmat.org/help.php.
HeretoHelp. Available from: www.heretohelp.bc.ca.
Kutcher S. Teen Mental Health. Available from: www.teenmentalhealth.org.
MoodGYM Training Program. Available from: www.moodgym.anu.edu.au/welcome.
National Institute of Mental Health. Depression. Available from:

www.nimh.nih.gov/health/topics/depression/index.shtml.
Patient Care Tools. Getting started with antidepressants. Staying on track with antidepressants. Available
from: medicationinfoshare.com/tools.
Suggested Readings
Lam RW, Kennedy SH, Grigoriadis S et al. Canadian Network for Mood and Anxiety Treatments (CANMAT)
clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy. J Affect
Disord 2009;117:S26-43.
Parikh SV, Segal ZV, Grigoriadis S et al. Canadian Network for Mood and Anxiety Treatments (CANMAT)
clinical guidelines for the management of major depressive disorder in adults. II. Psychotherapy alone or in
combination with antidepressant medication. J Affect Disord 2009;117:S15-25.
Patten SB, Kennedy SH, Lam RW et al. Canadian Network for Mood and Anxiety Treatments (CANMAT)
clinical guidelines for the management of major depressive disorder in adults. I. Classification, burden and
principles of management. J Affect Disord 2009;117:S5-14.
Ravindran AV, Lam RW, Filteau MJ et al. Canadian Network for Mood and Anxiety Treatments (CANMAT)
clinical guidelines for the management of major depressive disorder in adults. V. Complementary and
alternative medicine treatments. J Affect Disord 2009;117:S54-64.
Teter CJ, Kando JC, Wells BG et al. Major depressive disorder. In: DiPiro JT, Talbert RL, Yee GC et al., eds.
Pharmacotherapy: a pathophysiologic approach. 9th ed. New York: McGraw-Hill Medical; 2014. p. 1047-66.
References
1. Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature 2008;455:894-902.

2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th
ed. Washington: American Psychiatric Publishing; 2013.
3. Yatham LN, Kennedy SH, Parikh SV et al. Canadian Network for Mood and Anxiety Treatments
(CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT
guidelines for the management of patients with bipolar disorder: update 2013. Bipolar Disord
2013;15:1-44.
4. Lippi G, Montagnana M, Favaloro EJ et al. Mental depression and cardiovascular disease: a
multifaceted, bidirectional association. Semin Thromb Hemost 2009;35:325-36.
5. Lesman-Leegte I, van Veldehuisen DJ, Hillege HL et al. Depressive symptoms and outcomes in
patients with heart failure: data from the COACH study. Eur J Heart Fail 2009;11:1202-7.
6. Patten SB, Wang JL, Williams JV et al. Descriptive epidemiology of major depression in Canada. Can
J Psychiatry 2006;51:84-90.
7. Patten SB, Kennedy SH, Lam RW et al. Canadian Network for Mood and Anxiety Treatments
(CANMAT) clinical guidelines for the management of major depressive disorder in adults. I.
Classification, burden and principles of management. J Affect Disord 2009;117:S5-14.
8. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen
Intern Med 2001;16:606-13.
9. Whooley MA, Avins AL, Miranda J et al. Case-finding instruments for depression. Two questions are
as good as many. J Gen Intern Med 1997;12:439-45.
35. Papakostas GI, Mischoulon D, Shyu I et al. S-adenosyl methionine (SAMe) augmentation of serotonin
reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind,
randomized clinical trial. Am J Psychiatry 2010;167:942-8.
36. Fetrow CW, Avila JR. Efficacy of the dietary supplement of S-adenosyl-L-methionine. Ann
Pharmacother 2001;35:1414-25.
37. Parker G, Gibson NA, Brotchie H et al. Omega-3 fatty acids and mood disorders. Am J Psychiatry
2006;163:969-78.
38. Appleton KM, Sallis HM, Perry R et al. Omega-3 fatty acids for depression in adults. Cochrane
Database Syst Rev 2015;11:CD004692.
39. Freeman MP. Complementary and alternative medicine for perinatal depression. J Affect Disord
2009;112:1-10.
40. Kaviani M, Saniee L, Azima S et al. The effect of omega-3 fatty acid supplementation on maternal
depression during pregnancy: a double blind randomized controlled clinical trial. Int J Community
Based Nurs Midwifery 2014;2:142-7.
41. Sánchez-Villegas A, Doreste J, Schlatter J et al. Association between folate, vitamin B(6) and vitamin
B(12) intake and depression in the SUN cohort study. J Hum Nutr Diet 2009;22:122-33.
42. Skarupski KA, Tangney C, Li H et al. Longitudinal association of vitamin B-6, folate, and vitamin B-12
with depressive symptoms among older adults over time. Am J Clin Nutr 2010;92:330-5.
43. Bedson E, Bell D, Carr D et al. Folate Augmentation of Treatment—Evaluation for Depression
(FolATED): randomized trial and economic evaluation. Health Technol Assess 2014:18:1-159.
44. Anglin RE, Samaan Z, Walter SD et al. Vitamin D deficiency and depression in adults: systematic
review and meta-analysis. Br J Psychiatry 2013;202:100-7.
45. Morrato EH, Libby AM, Orton HD et al. Frequency of provider contact after FDA advisory on risk of
pediatric suicidality with SSRIs. Am J Psychiatry 2008;165:42-50.
46. Gagne JJ, Patrick AR, Wang PS et al. Health advisories and patterns of patient monitoring among
new users of antidepressant medications. J Clin Psychopharmacol 2009;29:590-4.
Information for the Patient

Depression
Depression—What You Need to Know
About 10% of people experience depression at some time in their life. It is not a sign of personal weakness. Depression is
caused by biochemical changes in the brain. It is often referred to as a “chemical imbalance.”
Depression can last weeks, months or even years before getting better on its own. But it will usually improve when treated
with medication or other kinds of therapy. Most people who get treatment (3 out of 4) find it works for them. Early treatment
reduces the chance of depression coming back.
How is depression treated?
Antidepressants are used to shorten the length of time it takes to get over an episode of depression.
You may start to feel better in 1–2 weeks, or it could take longer. Talk to your doctor if you don't notice any
improvement in symptoms or mood after 2 weeks.
Don't get discouraged if you don't feel better right away. Sometimes medications or dosages have to be
adjusted to get the full benefit.
Continue your medication even if you start to feel better. Taking your medication for the proper amount of time
lowers the chances of your depression coming back.
How long do you have to take antidepressant medication?
If you are being treated for depression for the first time, you may have to take medication for many months after
you get better.
If you have had depression more than once, you may have to take medication for 2 years or more.
What can you do to help your treatment?
Avoid alcohol. Many patients with depression drink alcohol to help them sleep or to “calm their nerves.” But
alcohol alters brain chemistry and disrupts sleep the same way depression does. Talk to your healthcare
provider to find out whether you can have an occasional alcoholic drink.
Do not use illegal drugs, sedatives or stimulants.
Tell your healthcare team if you take nonprescription medications, including herbal products. These products
may affect how your medication works.
Get plenty of rest.
Exercise regularly.
Eat regularly.
Keep socially active.
Do not make any major life changes. When you are feeling bad, it can be difficult to deal with problems. They
will seem more manageable when you are feeling better.
What happens if you stop taking antidepressant medication too soon?
Do not stop taking your antidepressant medication without consulting your healthcare practitioner.
Your healthcare practitioner must supervise the process of gradually reducing your medication. It may take
several weeks or several months to stop.
If you stop your antidepressant suddenly you may experience withdrawal symptoms. You may have any of these
symptoms:
flu-like symptoms
muscle aches
fatigue (tiredness) and headache
stomach or bowel upset
anxiety, irritability and mood changes
feelings like electric shocks throughout the body, especially in the arms and legs.
Does depression come back?
Some people do have recurring episodes of depression. Whether your depression comes back will depend on:
how long you have been depressed
the number of times you have had depression before
whether you have a family history of depression.
CPhA does not assume any legal liability and makes no representation or warranties concerning the accuracy, completeness, reliability or usefulness of
this information. Once printed there is no quarantee the information is up-to-date. [Printed on: 05-17-2018 11:42 PM]
RxTx, Minor Ailments: Information for Patients © Canadian Pharmacists Association, 2018. All rights reserved
Insomnia
Ric M. Procyshyn, PharmD, PhD

Alasdair M. Barr, PhD
Date of Revision: June 2017
Introduction
Insomnia disorder is the most prevalent of all sleep disorders. Although the term is used in a variety of ways,
most often it is defined by an individual's report of difficulty with sleep.1 From a medical perspective,
insomnia can be defined by the following DSM-5 diagnostic criteria:2
A. Dissatisfaction with sleep quantity or quality, despite adequate opportunity for sleep, as the
predominant complaint and ≥1 of the following symptoms:
a. Difficulty with sleep initiation. (Children may have difficulty falling sleep without help from
caregiver.)
b. Difficulty with sleep maintenance including frequent awakenings or problems returning to sleep.
(Children may have difficulty returning to sleep without help from caregiver.)
c. Early-morning awakening and unable to return to sleep.
B. Clinically significant distress or impairment in social, occupational, educational, academic, behavioral

or other important areas of functioning due to sleep disturbance.
C. Sleep difficulty occurs ≥3 nights per week and is present for ≥3 months.
D. Insomnia is not explained by, and does not occur exclusively during the course of, another sleep-wake
disorder (e.g., narcolepsy, a breathing-related sleep disorder, a circadian rhythm sleep-wake disorder).
E. Insomnia is not due to the physiologic effects of a substance (e.g., a drug of abuse, a medication) and
is not adequately explained by coexisting mental disorders and medical conditions.
Insomnia diagnosis is based on the patient's subjective complaints and does not always correlate with
objective measures such as sleep architecture, i.e., cyclic phases of REM (rapid eye movement) and non-
REM sleep, or with a specific number of hours of sleep each night.3 For a description of specific types of
insomnia disorder, see Table 1.
Apart from insomnia disorder, there are other common sleep-wake disorders that include the following:
Situational/acute insomnia:
Often associated with life events or with changes in sleep schedules and lasts a few days to a few
weeks
May result in significant distress and interfere with social, personal and occupational functioning
Circadian rhythm sleep-wake disorders:
Insomnia occurs only when trying to sleep at socially normal times, but not when bed and rising
times are delayed and coincide with their endogenous circadian rhythm
Restless legs syndrome:
An urge to move the legs and any accompanying unpleasant leg sensations are features that
differentiate this disorder from insomnia disorder
Breathing-related sleep disorders:
Usually accompanied by a history of loud snoring, breathing pauses, and excessive daytime
sleepiness
Up to 50% of individuals with sleep apnea may report symptoms of insomnia disorder
Narcolepsy:
Distinguished from insomnia disorder by the predominance of symptoms of excessive daytime
sleepiness, cataplexy, sleep paralysis, and sleep-related hallucinations
Parasomnias:
Unusual behavior or events during sleep that may lead to intermittent awakenings and difficulty
resuming sleep
Substance/medication-induced sleep disorder:
Differs from insomnia disorder in that a substance is judged to be etiologically related to the
insomnia.
Pathophysiology
Insomnia is believed to be a disorder of hyperarousal that is experienced throughout the entire day. Currently,
there are 2 models that attempt to explain this hyperarousal state. The cognitive model suggests that life's
stressors cause an individual to worry and ruminate to the point that they have difficulty falling asleep or
going back to sleep once awakened.4 After a period of time, the focus of worry and rumination shifts to the
lack of sleep itself and its effect on functioning the next day.
Another model suggests that hyperarousal is due to physiologic factors, based on the significantly higher
metabolic rates seen in patients with insomnia compared with healthy controls.5 The neuroendocrine
system may also play a role in hyperarousal as evidenced by increased levels of urinary and plasma cortisol
and adrenocorticotropic hormone (ACTH) in persons suffering from insomnia.6,7
Prevalence
Depending on the diagnostic criteria used and population studied, widely variable prevalence rates of
insomnia have been reported (5–50%). In epidemiologic studies assessing insomnia symptoms without
restrictive criteria, the prevalence is approximately 33% in the general population.8 If more stringent
diagnostic criteria are applied, in which the symptoms of insomnia must persist for at least 1 month and not
occur exclusively during the course of another sleep disorder, mental disorder or as the direct physiologic
effects of a substance or medical condition, the estimated prevalence is approximately 6%.9
Insomnia is reportedly more common in women than men (ratio 1.4:1), in elderly patients (particularly those
with health problems), and in patients with comorbid psychiatric or medical illness.8,10 Use of certain
medications has also been associated with insomnia (Table 2).
Insomnia is associated with more frequent use of healthcare services, more days with limited activity, more
days spent in bed, impaired job performance, higher rates of absenteeism, increased risk of traffic and
workplace accidents and reduced quality of life.11,12 Insomnia appears to be a predictor of psychiatric and
medical comorbidities including depression,13 hypertension,14 diabetes15 and cardiac events,16 all of which
contribute to an increase in healthcare utilization.17 The impact of insomnia on overall health and well-being
highlights the importance of making treatment options available to affected individuals.
Classification
Insomnia is no longer classified as primary or secondary in DSM-5. The diagnosis of insomnia disorder is
given whether it is an independent condition or a comorbidity with a mental disorder, a medical condition or
a different sleep disorder.1,2 The duration of symptoms can be episodic (1–2 months), persistent (≥3
months) or recurrent (2 or more episodes in 1 year).
Table 1: Specifiers of Insomnia

Specifier Associated Factors
Independent condition Acute emotional or physical discomfort (acute illness; environmental

(no identifiable medical disturbance such as noise, light and temperature; hospitalization; jet lag;
cause) life stress)
Acute stressor usually related to work or family life (death or illness of a
loved one, loss of job)
Comorbid with another Dementia, eating disorders, mood, anxiety or psychotic disorders,
mental disorder substance-use disorders
Comorbid with a Cardiovascular disorders (e.g., cerebrovascular disease, heart disease,
medical condition untreated hypertension); chronic pain; GI conditions (e.g.,
gastroesophageal reflux disease, stomach or gastric ulcer); hormonal
changes (e.g., menopause, perimenopause, pregnancy); infection;
neurologic conditions (e.g., epilepsy, head injury, Huntington's disease,
migraine, Parkinson's disease); obstructive airway diseases; rheumatic
diseases (e.g., arthritis)
Comorbid with another Breathing-related sleep disorder (i.e., obstructive sleep apnea,
sleep disorder hypoapnea, central sleep apnea, sleep-related hypoventilation); circadian
rhythm sleep-wake disorders (i.e., delayed sleep phase type, advanced
sleep phase type, irregular sleep-wake type, non-24–hour sleep-wake
type, shift work type); parasomnias (i.e., non-rapid eye movement sleep
arousal disorders, nightmare disorder, rapid eye movement sleep
behavior disorder, restless legs syndrome)
Goals of Therapy
Promote a sound and satisfying sleep (sleep initiation, quality, quantity and continuity) to prevent
deterioration of daytime performance
Resolve or mitigate underlying conditions that may be contributing to insomnia
Prevent the progression from transient to chronic insomnia
Promote healthy sleep hygiene practices
Prevent excessive use of sedatives by recommending medication only when necessary
Patient Assessment
An assessment plan for patients suffering from insomnia is illustrated in Figure 1.
Table 2 lists medications that have been associated with insomnia.
2,19
Table 2: Drugs Associated with Insomnia
Drug Comments
Alcohol Acute intoxication may produce increased wakefulness, restless sleep,
and vivid and anxiety-laden dreams. Alcohol can aggravate breathing-
related sleep disorders. With chronic use, alcohol has a short-lived
sedative effect for the first half of the night, followed by sleep disruption
in the second half.
Caffeine Produces insomnia in a dose-dependent manner.
Cannabis Acute use may shorten sleep latency though arousing effects with
increments in sleep latency also occur. In chronic users, tolerance to the
sleep-inducing effect develops. Upon withdrawal, sleep difficulties and
unpleasant dreams may last for several weeks.
Opioids With chronic use, tolerance to the sedative effects develops followed by
complaints of insomnia.
Drug Comments
Sedatives, hypnotics, Acute intoxication produces the expected increase in sleepiness and
or anxiolytics (e.g., decrease in wakefulness. Chronic use may cause tolerance with
benzodiazepines) subsequent return of insomnia. Sedative-hypnotics can increase the
frequency and severity of obstructive sleep apnea events. Parasomnias
are associated with benzodiazepines. Abrupt discontinuation of chronic
use can lead to withdrawal and rebound insomnia.
Amphetamines (or Acute intoxication characterized by insomnia whereas withdrawal results

other stimulants, e.g., in excessive sleepiness. Drugs like ecstasy lead to restless and disturbed
methylphenidate) sleep within 48 hours of intake.
Nicotine Chronic use associated with symptoms of insomnia, with a reduction of

sleep efficiency, and increased daytime sleepiness. Withdrawal from
tobacco can lead to impaired sleep. Heavy smokers may have regular
nocturnal awakenings caused by tobacco craving.
Other non- Related to various effects on the central or autonomic nervous system.
psychotropic
substances including:
adrenergic agonists
and antagonists (e.g.,
antihypertensives,
bronchodilators)
antihistamines
cholinergic agonists
and antagonists
corticosteroids
dopamine agonists
and antagonists
hormonal therapy
(e.g., anabolic
steroids, estrogen,
medroxyprogesterone,
oral contraceptives,
progesterone, thyroid
hormone)
serotonergic
modulators (e.g.,
bupropion, MAO
inhibitors, SSRIs)
A task force appointed by the American Academy of Sleep Medicine has reviewed and graded evidence
regarding nonpharmacologic therapies for the treatment of chronic insomnia.20 Their findings support both
psychological and behavioural interventions, with the strongest evidence for stimulus control therapy,
relaxation training and cognitive-behavioural therapy.20,21,22 Sleep restriction therapy, multicomponent
therapy (without cognitive therapy), biofeedback and paradoxical intention are also considered effective, but
the evidence for their efficacy is not as strong. Sleep hygiene education is recommended as a general
measure but has not been shown to be effective as monotherapy in the treatment of insomnia.23,24
Cognitive-behavioural Therapy
Cognitive-behavioural therapy for insomnia (CBT-I) consists of any of the recommended behavioral
therapies (e.g., stimulus-control, sleep hygiene education, sleep restriction) in combination with cognitive
procedures, such as identifying dysfunctional beliefs and attitudes about sleep and replacing them with
a more adaptive substitute. It is aimed at creating a new attitude to minimize anticipatory anxiety and
arousal that can interfere with sleep. CBT-I should be offered to all patients as it has proven to be more
effective than medication for the treatment of chronic and persistent insomnia, particularly in long-term
maintenance.25,26,27,28 [Evidence: SORT A] The Canadian Toward Optimized Practice (TOP) 2015
guidelines recommend CBT-I as first-line treatment for both acute and chronic insomnia.29 The following
pamphlet provides information about on-line CBT-I resources for the treatment of chronic insomnia:
www.medicationinfoshare.com/gallery/online-cbt-for-insomnia/.
Stimulus-control Therapy
Stimulus-control therapy is based on the concept that sleep is a conditioned response to temporal
(bedtime) and environmental cues. The focus of stimulus-control therapy is to eliminate maladaptive
behaviours, with the overall goal of associating the bedroom with sleep. These measures complement
and are often included in general sleep hygiene recommendations.
Go to bed only when tired.

Use the bedroom only for sleep and sex.
Get up at the same time in the morning regardless of sleep duration.
Avoid napping during the day.
If unable to sleep after 15–20 minutes, get out of bed and go to another room to read in a dimly lit
environment. Avoid watching television or a computer screen as the light emitted from such
devices may have an arousing effect. Return to bed when feeling sleepy.
Relaxation Techniques
Relaxation techniques may improve sleep latency times and sleep maintenance and may be particularly
helpful in cases where hyperarousal is believed to be the cause of insomnia. These techniques include
the following:
Progressive muscle relaxation is based on the premise that mental relaxation will be a natural
outcome of physical relaxation. Muscle groups are tightened and relaxed one at a time in a specific
order. A greater degree of muscle tension is attempted in subsequent exercises as the patient
becomes familiar with the technique
Biofeedback is a therapeutic technique that teaches patients how to facilitate increased slow brain
wave activity by using electroencephalographic (EEG) monitoring. Eventually the patient is able to
apply this skill without the use of the EEG
Imagery training is a relaxation technique that teaches the patient to substitute pleasant, calm and
peaceful thoughts for unpleasant ones in order to reduce worry and stress.
Sleep Restriction
Sleep restriction involves controlling the amount of time spent in bed but increasing the percentage of
time asleep. For example, a patient who sleeps for only 6 hours but stays in bed for 8 hours per night
would be asked to decrease the time in bed to 7 hours (sleep time, plus 50% of nonsleep time). This
would be accomplished by changing the bedtime while maintaining the wake-up time to establish a good
sleep-wake cycle. The mild state of intentional sleep deprivation promotes more rapid sleep onset and
more efficient sleep. The allowable time in bed is gradually lengthened by 30 minutes as sleep efficiency
increases. In a randomized controlled trial, patients with insomnia independent of other specifiers
reported improved sleep and reduced fatigue with sleep restriction therapy.30
Multicomponent Therapy
Multicomponent therapy combines several different interventions and may include cognitive, behavioural
and sleep hygiene components.
Paradoxical Intention
Paradoxical intention focuses on removing performance anxiety by having the patient partake in their
most feared behaviour (remaining awake). In the case of insomnia, patients try to remain awake as long
as possible when in bed, with their eyes open and the room darkened. By changing the emphasis from
falling asleep to staying awake, the performance anxiety associated with trying to fall asleep slowly
disappears. Advise patients to avoid activities in the bedroom that are incompatible with sleep such as
keeping the lights on, reading, watching television or using a computer device with a lighted screen.
Sleep Hygiene Education
General sleep hygiene education focuses on behavioural and environmental factors that precede sleep
and that may interfere with sleep. Stimulus control measures (above) are often included in sleep hygiene
recommendations.
Personal habits:
Fix a bedtime and an awakening time
Avoid caffeine 4–6 hours before bedtime and minimize total daily intake
Avoid nicotine near bedtime and upon awakening at night
Avoid alcohol 4–6 hours before bedtime
Avoid heavy, spicy or sugary foods 4–6 hours before bedtime
Exercise regularly, but not right before bed
Sleeping environment:
Use comfortable bedding
Find a comfortable temperature setting for sleeping and keep the room well ventilated
Block out all distracting noise
Getting ready for bed:
Try a light snack before bed such as warm milk and foods high in the amino acid tryptophan
(e.g., bananas)
Try relaxation techniques before bed
Don't take your worries to bed
Establish a pre-sleep ritual such as a warm bath or a few minutes of reading
Get into your favourite sleeping position
Ailments—Sleep Aid Products.
Diphenhydramine, an antihistamine with significant sedative effect,31,32 is the mainstay of nonprescription

pharmacotherapy for insomnia and is described in Table 4.
Principles for nonprescription therapy include:33
Consider potential contraindications and adverse effects

May not be suitable in the elderly because of anticholinergic side effects
Use the lowest effective dose
Use intermittent dosing (up to 4 times weekly)
Use short term, no longer than 7 consecutive days
Discontinue medication gradually if used long term.
Prescription therapy for insomnia includes primarily benzodiazepines (e.g., lorazepam, oxazepam,
temazepam)34,35 and nonbenzodiazepine GABA agonists (zolpidem, zopiclone).36 Barbiturates and other
hypnotics such as chloral hydrate are no longer recommended for the management of insomnia due to an
unacceptable risk/benefit profile and rapid development of tolerance, respectively. Antidepressants have
been used, particularly in patients with depressive symptoms, but with the exception of trazodone,29 their
use solely for insomnia is not generally supported.37
For further information on prescription therapy, consult the Compendium of Therapeutic Choices: Insomnia.
Pharmacotherapy for insomnia should be recommended with caution, as these agents are associated with
cognitive impairment, increased risk of falls, work-related injuries, tolerance, dependence, withdrawal and
rebound effects.38 Nonbenzodiazepine GABA agonists are also associated with decreased mental alertness
and driving impairment the morning after use, despite the patient feeling fully alert.39,40 Nonpharmacologic
treatment of insomnia (e.g., CBT-I) has proven to be a safe and effective alternative to
pharmacotherapy,25,26,27 and should be considered a first-line treatment option.
Ailments—Herbal and Natural Health Products: Combinations, Single Entity; Sleep Aid Products.
Valerian (Valeriana officinalis) is marketed as a nonprescription therapy for insomnia. A systematic

review and meta-analysis reported subjective improvement in sleep quality when outcome was
measured as a dichotomous variable (i.e., yes or no).41 However, most of the studies had significant
problems with methodology and considerable variation in the doses, preparations and treatment lengths.
Cases of hepatotoxicity have been reported with valerian use. One case of severe withdrawal syndrome
was reported after long-term, high-dose valerian therapy. Valerian is not recommended during pregnancy
and breastfeeding.
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone produced primarily by the pineal gland.

Commercially available animal-sourced melatonin must be isolated only from the pineal glands of
animals that are not susceptible to transmissible spongiform encephalopathy (TSE) diseases including
bovine spongiform encephalopathy (BSE). Melatonin has been reported to increase total sleep time,
relieve or prevent daytime fatigue associated with jet lag, reduce sleep latency and help reset the body's
sleep-wake cycle.42 A meta-analysis reported that melatonin decreases sleep onset latency, increases
total sleep time and improves overall sleep quality.43 However, it also found that the absolute benefit of
melatonin compared with placebo is smaller than other pharmacological treatments for insomnia. The
overall evidence for its use in insomnia is weak. Fatigue, headache, dizziness, irritability and abdominal
cramps are possible side effects.
There is insufficient evidence to recommend use of herbals such as German chamomile (Matricaria
recutita), eleuthero (Siberian ginseng), passion flower (Passiflora), reishi (Ganoderma lucidum), lavender
(Lavandula angustifolia), wild lettuce (Lactuca virosa), hops (Humulus lupulus) and St. John's wort
(Hypericum perforatum) for insomnia. Kava kava (Piper methysticum) may promote sleep but was
removed from the Canadian market in 2002 because of reports of hepatotoxicity.
Table 3 provides a framework for a monitoring plan that should be individualized.
Points to cover when counselling patients who choose nonprescription drug therapy for insomnia:
Potential benefits of stimulus control and relaxation training; sleep hygiene education should also be
reinforced (see Nonpharmacologic Therapy)
Do not operate vehicles or machinery or engage in any potentially hazardous activities while under the
influence of sedating medication
Do not combine sedating drug therapy with alcohol
Expected outcomes of drug therapy and management of side effects (Table 3).
21,44
Table 3: Monitoring of Nonprescription Therapy for Insomnia
Symptoms/Side Therapeutic Goals Frequency Actions
Effects of
Monitoring
Inability to fall Decrease in sleep latency to ≤30 min Patient: If ineffective
asleep Daily while after 3
on drug evenings of
therapy therapy and
Healthcare treatment
Frequent Decrease in or no nocturnal awakenings still required,
practitioner:
nocturnal assess for
After 3 and
awakenings further
7 days of
therapy or therapy or
next visit consultation.
If drug
Early morning Duration of sleep between 5–7 h per night therapy is
awakening required for
more than 7
consecutive
days, assess
Reduced overall Improved subjective sleep quality with 3 nights
for further
quality of sleep of therapy
therapy or
consultation.
Morning Minimal/acceptable morning drowsiness, Patient or Decrease

drowsiness, grogginess and/or dizziness throughout family dose by 50%.
grogginess therapy member: If still a
and/or dizziness Daily problem
(elderly are more Healthcare after dosage
at risk) practitioner: adjustment
After 3 and and therapy
7 days of still required,
therapy or assess for
next visit further
therapy or
consultation.
Symptoms/Side Therapeutic Goals Frequency Actions
Effects of
Monitoring
Constipation Minimal constipation throughout therapy Patient: Discontinue
(adverse effect of Every 3 therapy.
diphenhydramine; days Increase
elderly are more Healthcare dietary fibre,
at risk) practitioner: water intake
Within 1 wk and exercise.
or next visit If no
improvement
in bowel
function,
recommend
a laxative.
Confusion No confusion throughout therapy Family: Discontinue

(adverse effect of Daily therapy
diphenhydramine; Healthcare immediately
elderly are more practitioner: and assess
at risk) Within 1 wk for further
or next visit therapy or
consultation.
Algorithms
18
Figure 1: Assessment of Patient with Insomnia
a Ask patient to maintain a sleep diary. See Insomnia—What You Need to Know.
Drug Table
Table 4: Nonprescription Medications for Insomnia
Drug/Costa Dosage Adverse Drug Comments

Effects Interactions
Drug Class: Antihistamines

diphenhydramine 12.5–50 mg po Dizziness (8%), Additive Recommend

Nytol, Sleep-Eze, 30–60 min grogginess sedation with intermittent use
Unisom, ZzzQuil, before bedtime. (10–19%), alcohol or other only (≤4 times
generics Optimal dose: 50 morning sedating weekly).
mg po. Slight drowsiness medications. Limited evidence to
$$ dose-dependent (10–15%). Inhibits support efficacy.
increase in Anticholinergic CYP2D6 and
hypnotic effect can increase Patient should
side effects seek professional
at doses ≤50 mg, (e.g., urinary serum levels of
especially in many drugs advice if required
retention, dry for >7 days.
hypnotic-naïve mouth, including
patients; flat antidepressants Contraindicated in
constipation),
dose response and patients with
of particular
with doses >50 cardiovascular benign prostatic
concern in
mg drugs. hyperplasia,
elderly.
constipation,
Impaired dementia/cognitive
psychomotor impairment, dry
and cognitive mouth, dry eyes,
function. glaucoma, heart
Increased risk disease.
of delirium, Beers criteria
particularly in recommends
elderly. against use of
May lower diphenhydramine
seizure in the elderly due to
threshold. increased risk of
anticholinergic
toxicity, delirium
and CNS adverse
effects.
Dimenhydrinate
contains 50–55%
diphenhydramine.

melatonin 0.3–5 mg po Fatigue, Melatonin is a May relieve

30–60 min headache, substrate of insomnia related to
$ before bedtime dizziness, CYP1A2; its jet lag. Limited
irritability and metabolism evidence to
abdominal may be support efficacy.
cramps affected by Patient should
strong CYP1A2 seek professional
inhibitors (e.g., advice if required
ciprofloxacin, for >7 days.
fluvoxamine) or
inducers (e.g.,
carbamazepine,
rifampin).
Decreased
efficacy of
dihydropyridine
calcium
channel
blockers (e.g.,
amlodipine,
nifedipine,
nicardipine).
valerian 400–900 mg po Dizziness, Additive Not recommended

30–60 min nausea, sedation with during pregnancy
$$ before bedtime headache, alcohol or other and breastfeeding.
upset sedating Cases of
stomach, medications. hepatotoxicity have
morning Combinations been reported.
hangover should be Limited evidence to
avoided or used support efficacy.
with caution. Patient should
seek professional
advice if required
for >7 days.
a Cost of 7-day supply; includes drug cost only.
Legend: $ < $1 $$ $1–2
Resource Tips
Mayo Clinic. Insomnia. Available from: www.mayoclinic.org/diseases-conditions/insomnia/home/ovc-
20256955.
Sleepnet.com. Available from: www.sleepnet.com.
Sleepwell Nova Scotia. Available from: www.sleepwellns.ca
Suggested Readings
Benca RM. Diagnosis and treatment of chronic insomnia: a review. Psychiatr Serv 2005;56:332-43.
McMillan JM, Aitken E, Holroyd-Leduc JM. Management of insomnia and long-term use of sedative-hypnotic
drugs in older patients. CMAJ 2013;185:1499-505.
Morin CM, Benca R. Chronic insomnia. Lancet 2012;379:1129-41.
Passarella S, Duong MT. Diagnosis and treatment of insomnia. Am J Health Syst Pharm 2008;65:927-34.
Roehrs T, Roth T. Insomnia pharmacotherapy. Neurotherapeutics 2012;9:728-38.
Toward Optimized Practice (TOP) Insomnia Group. Assessment to management of adult insomnia: clinical
practice guideline. December 2015. Available from:
www.topalbertadoctors.org/download/1920/Adult%20Insomnia%20CPG.pdf.
References
1. Roth T. Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med 2007;3:S7-10.
2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th
ed. Washington: American Psychiatric Publishing; 2013.
3. Erman MK. Sleep architecture and its relationship to insomnia. J Clin Psychiatry 2001;62:9-17.
4. Harvey AG. A cognitive model of insomnia. Behav Res Ther 2002;40:869-93.
5. Bonnet MH, Arand DL. 24-hour metabolic rate in insomniacs and matched normal sleepers. Sleep
1995;18:581-8.
6. Vgontzas AN, Bixler EO, Lin HM et al. Chronic insomnia is associated with nyctohemeral activation of
the hypothalamic-pituitary-adrenal axis: clinical implications. J Clin Endocrinol Metab 2001;86:3787-
94.
7. Riemann D, Klein T, Rodenbeck A et al. Nocturnal cortisol and melatonin secretion in primary
insomnia. Psychiatry Res 2002;113:17-27.
8. Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med
Rev 2002;6:97-111.
9. Ohayon MM. Prevalence of DSM-IV diagnostic criteria of insomnia: distinguishing insomnia related
to mental disorders from sleep disorders. J Psychiatr Res 1997;31:333-46.
10. Ohayon MM, Shapiro CM, Kennedy SH. Differentiating DSM-IV anxiety and depressive disorders in
the general population: comorbidity and treatment consequences. Can J Psychiatry 2000;45:166-72.
11. Simon GE, VonKorff M. Prevalence, burden, and treatment of insomnia in primary care. Am J
Psychiatry 1997;154:1417-23.
12. Bonnet MH, Arand DL. Consequences of insomnia. Sleep Med Clin 2006;1:351-8.
13. Breslau N, Roth T, Rosenthal L et al. Sleep disturbance and psychiatric disorders: a longitudinal
epidemiological study of young adults. Biol Psychiatry 1996;39:411-8.
14. Suka M, Yoshida K, Sugimori H. Persistent insomnia is a predictor of hypertension in Japanese male
workers. J Occup Health 2003;45:344-50.
15. Nilsson PM, Roost M, Engstrom G et al. Incidence of diabetes in middle-aged men is related to sleep
disturbances. Diabetes Care 2004;27:2464-9.
16. Asplund R. Sleep and cardiac diseases amongst elderly people. J Intern Med 1994;236:65-71.
17. Walsh JK. Clinical and socioeconomic correlates of insomnia. J Clin Psychiatry 2004;65:13-9.
18. Schenck CH, Mahowald MW, Sack RL. Assessment and management of insomnia. JAMA
2003;289:2475-9.
19. Novak M, Shapiro CM. Drug-induced sleep disturbances. Focus on nonpsychotropic medications.
Drug Saf 1997;16:133-49.
20. Morin CM, Bootzin RR, Buysse DJ et al. Psychological and behavioral treatment of insomnia: update
of the recent evidence (1984-2004). Sleep 2006:29;1398-414.
21. Morgenthaler T, Kramer M, Alessi C et al. Practice parameters for the psychological and behavioral
treatment of insomnia: an update. An American Academy of Sleep Medicine report. Sleep
2006;29:1415-9.
22. Morin CM, Hauri PJ, Espie CA et al. Nonpharmacologic treatment of chronic insomnia. An American
Academy of Sleep Medicine review. Sleep 1999;22:1134-56.
23. University of Maryland Medical Center. Sleep Disorders Center. Sleep hygiene: helpful hints to help
you sleep. Available from: www.ummidtown.org/programs/sleep/patients/sleep-hygiene. Accessed
June 11, 2015.
1. Smoking tools such as ash trays and lighters should be removed
from the home, car and workspace.
2. Beneficial, especially in the first few weeks after the quit date, to
Smoking Cessation
avoid or limit interaction with friends or family members who
smoke.
Kristine Petrasko, BScPharm, CRE
Manjit Bains, BScPharm 3. To help deal with cravings, advise patients to take a walk,
Date of Revision: August 2017 practise breathing techniques, or take up a new hobby or project.
Peer Review Date: March 2016 4. Suggest healthy, crunchy snacks such as carrot sticks or celery
to help with cravings and the increased hunger that can be
Pathophysiology associated with tobacco cessation.
Nicotine addiction involves a variety of physical, psychological and behavioural factors.1,2,3 Nicotine acts as a
stimulant, increasing alertness and sense of well-being and elevating heart rate and blood pressure. Due to rapid
delivery (within 7–10 seconds) to the mesolimbic pleasure-reward system in the brain, nicotine is highly addictive.
With continued use, chemical and biologic changes occur in the brain and tolerance develops very quickly. Nicotine
addiction is characterized by cravings which promote continued smoking and the tendency to increase nicotine
intake to counter the profound physical and psychological symptoms elicited by withdrawal. There are multiple
ways to consume nicotine: smoking, chewing or snorting smokeless tobacco, vaping and others. Table 1 describes
various factors that reinforce nicotine addiction.
Nicotine addiction is now classified in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5)
as tobacco use disorder.3
Table 1: Factors Reinforcing Nicotine Addiction
Category Reinforcing Factors3,4,5
Physical Pleasure or “high” similar to other addictive psychomotor stimulants.
Psychological Behavioural conditioning resulting from hand-to-mouth ritual repeated on

average 250 times a day for a pack-a-day smoker.
Fear of weight gain associated with quitting.
Social Routine activities associated with smoking such as waking up, phone calls,
meals, coffee, driving, break time at work, spending time with family or friends
who smoke. Quitting does not eliminate these activities so they continue to
act as triggers.
Withdrawal Symptoms Dysphoric or depressed mood, irritability, anxiety, difficulty concentrating,

restlessness, increased appetite/weight gain, GI symptoms, headaches and
insomnia.
Symptoms generally peak 24–72 h after the last cigarette and subside after
about 2 wk.
Cravings can continue for years, and are probably related to behavioural and
psychological aspects of nicotine addiction.
Prevalence
About 4.6 million Canadians (16% of the population) currently smoke.6 Smoking tobacco is the number one
cause of preventable death in Canada, killing over 37 000 people every year, which is more than car accidents,
suicides, homicides, AIDS and other substance abuse issues combined.6 Now considered a chronic medical
condition,7 tobacco dependency is the inability to discontinue tobacco use despite awareness of the health
consequences.8 All forms of tobacco use have harmful effects. These include smokeless tobacco (chewing
tobacco and “snuff”), pipe tobacco, cigars, hookahs and other nicotine delivery systems.7,9
Health Risks
On average, a cigarette delivers 1–3 mg of nicotine to the brain.2,10 Light or ultralight cigarettes may deliver the
same amount of nicotine as regular cigarettes, regardless of the reported nicotine content, and are not safer
than regular cigarettes.10 Many factors are involved, such as more intense inhalation (“compensation”) or
blocking of the vent holes on the cigarette filter by the lips or fingers.
The health risks associated with smoking (see Table 2) are attributable to at least 50 of the known carcinogens
among the 4000 chemicals in tobacco smoke, including: tar, arsenic, formaldehyde, ammonia and nickel.
Environmental tobacco smoke (ETS) or second-hand smoke puts nonsmokers at risk, accounting for over 1000
lung cancer or cardiac deaths each year.6 Patients with chronic lung conditions may be most susceptible to ETS,
with increased risk of asthma or COPD exacerbations. However, all nonsmokers are at risk of the effects of ETS,
which also include eye and throat irritation, coughing, rhinitis, headaches and various types of cancer,
particularly lung cancer. In children it has also been linked to asthma, recurrent acute otitis media and sudden
infant death syndrome.11
For those who do quit, there are immediate and long-term health benefits: improved breathing and sense of
taste, and reduced risk of heart disease, cancer, respiratory problems and infections. Long-term smoking
cessation has also been associated with mental health benefits, including improvements in depression, anxiety
and stress.12 Quitting before the age of 50 results in a 50% reduction in risk of death in the next 15 years.13 The
younger a person is when quitting, the better their overall quality of life, with a significant decrease in
mortality.14,15 Compared with those who continue to smoke, people who stop smoking when aged 25–34, 35–
44, 45–54 and 55–64 lived 10, 9, 6 and 4 years longer, respectively.16 This highlights the importance of assisting
younger smokers to quit, and more importantly, preventing them from starting in the first place. It is also
important to emphasize to patients with a long history of smoking that it is never too late to quit.
Table 2: Health Risks Associated with Tobacco Use

Category Potential Health Effects
Cancer Cancer of the lung, pancreas, kidney, bladder, lip, oral cavity and pharynx,
esophagus and larynx are all increased 2–27 times for smokers compared with
nonsmokers. Smoking accounts for about 30% of all cancer-related deaths.17
Cardiovascular Smokers have 2–4 times higher risk of coronary artery disease, 1.5 times higher
risk of cerebral thrombosis18 and increased risk of arteriosclerotic peripheral
vascular disease.19 Smoking cessation is an effective means of cardiovascular risk
reduction and should be assessed in addition to blood pressure, lipid and blood
glucose control.
Delayed wound Wounds resulting from trauma, disease, or surgical procedures heal slowly in
healing smokers. Smokers experience a greater degree of complications as well as a
higher incidence of unsatisfactory healing following reconstructive surgeries.20
Dermatologic Premature aging of skin and wrinkling.21

effects
Endocrine Chronic smokers develop insulin resistance. There is also an increased risk of
microvascular complications in smokers who develop insulin resistance.22
Musculoskeletal Increased risk of lumbar disk disease and delayed bone healing.
effects Decreased bone mineral density; though evidence of causality is lacking, bone loss
associated with smoking could be expected to increase risk of hip fracture,
especially in postmenopausal women.23,24,25
Oral Cardiovascular events, including stroke and MI, are more common in women ≥35 y
contraceptive taking oral contraceptives.26
use
Category Potential Health Effects
Oral diseases Smoking increases the risk of oral diseases such as leukoplakia (white
premalignant lesions on oral mucosa), gingival bleeding, periodontitis and
ulcerative gingivitis, as well as lip, mouth and throat cancers that resulted in the
deaths of 1108 Canadians in 2007.27
Peptic ulcer Increased incidence of bleeding and perforated ulcers.

disease
Pregnancy and Smoking during pregnancy has been linked to increased risk of: intrauterine growth
postpartum restriction (average 150 g lower birth weight at term); preterm and extremely
preterm births; fetal and infant mortality; sudden infant death syndrome (SIDS);
potential long-term effects such as increased risk of type 2 diabetes, obesity,
asthma, certain childhood cancers.28,29,30
Respiratory Smoking leads to chronic obstructive pulmonary disease (COPD) including chronic
bronchitis and emphysema,31 as well as a higher incidence of lung and throat
infections.32
Patients requiring inhaled corticosteroids have less of a response than
nonsmokers.
Sexual function Erectile dysfunction is twice as likely to occur in smokers than nonsmokers;
exposure to second-hand smoke is also a significant risk factor for erectile
dysfunction.18
Goals of Therapy
The foremost goal of therapy is to achieve lasting smoking cessation. Healthcare practitioners can help patients
achieve this goal by:
Supporting smokers in the pre-contemplative and contemplative stages of change to move to preparation and
then action stages.
Supporting smokers who successfully quit to achieve long-term abstinence (maintenance stage).
These goals may be achieved by initiating dialogue, providing education and following up regularly with
patients.
Patient Assessment
Healthcare practitioners are in an ideal position not only to help patients who have already decided to quit smoking,
but also to identify smokers and assist them in making the decision to quit. An assessment plan for smoking
cessation is presented in Figure 2.
Healthcare practitioners should take the initiative to provide, at minimum, a brief intervention (<20 minutes) to
assess smoking status and readiness to quit. This type of intervention can increase unassisted quit rates of 2–3%
by a further 1–3%.33 Longer consultations (30–90 minutes) are even more effective.7,34,35,36 Though effectiveness
is higher with longer interviews, brief interventions of even 3–5 minutes have been shown to be beneficial.33
The following 3 main assessment questions can be used to initiate a brief intervention or discussion with a patient:
1. Do you smoke?
2. Have you ever considered quitting?
3. Is now a good time?

The patient's motivation to quit is assessed by the Stages of Change model of behavioural change (see Figure 2).
The precontemplation stage describes the patient who is not even thinking about quitting. In the contemplation
stage, the patient is considering quitting, typically in the next 6 months to a year. In the preparation stage, the
patient has made the decision to quit and is preparing to begin the process. Next is the action stage where quitting
actually occurs, followed by maintenance, where the patient has been abstinent for at least 6 months and is working
at remaining smoke-free. See Figure 2 and Nonpharmacologic Therapy for intervention strategies for each stage of
the process.
If the degree of physical dependence is low as assessed by the Modified Fagerström Nicotine Tolerance Scale (see
Table 3), the chances of successful smoking cessation are good even with behavioural assistance alone. If the
degree of physical dependence is high, e.g., Fagerström score ≥6, the patient will likely require some form of
pharmacotherapy (with or without behavioural assistance) to achieve success.7
Table 3: Modified Fagerström Nicotine Tolerance Scale
Questionsa 0 points 1 point 2 points 3 points Scoreb

1. How soon after you wake up do you After 60 Within 31– Within 6– Within 5
smoke your first cigarette? min 60 min 30 min min ___
2. Do you find it difficult to refrain from No Yes – –

smoking in places where it is
forbidden? ___
3. Which of all the cigarettes you smoke Any other First one in – –
in a day is the most satisfying one (the than first the
hardest one to give up)? one in the morning
morning ___
4. How many cigarettes per day do you 10 or less 11–20 21–30 31 or more
smoke? ___
5. Do you smoke more during the No Yes – –

morning than during the rest of the
day? ___
6. Do you smoke when you are so ill No Yes – –

that you are in bed most of the day? ___
Total: ___
a
For some nicotine replacement products, only question 1 or 4 is required to determine the appropriate initial dose.
b Initiate pharmacotherapy for scores ≥6.
Score: <5 = low nicotine dependence; 5 = moderate nicotine dependence; 6–7 = high nicotine dependence; 8–10 = very high
nicotine dependence
Adapted with permission from Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO. The Fagerström Test for Nicotine Dependence: a revision of
the Fagerström Tolerance Questionnaire. Br J Addict 1991;86:1119-27.
Nonpharmacologic therapy for smoking cessation includes various behavioural interventions and alternative
therapies. Combining one or more of these methods may be sufficient for success in patients who are light
smokers. It is also the most appropriate option for patients in whom pharmacologic therapy is contraindicated
because of potential interaction with other medications or because of other physical conditions such as severe
heart disease (see Cardiovascular Disease) or pregnancy (see Pregnancy).
Environmental changes can be made to assist a person in tobacco cessation. Smoking paraphernalia such as ash
trays and lighters should be removed from the home, car and workspace. It may also be beneficial, especially in the
first few weeks after the quit date, to avoid or limit interaction with friends or family members who smoke. To help
deal with cravings, advise patients to take a walk, practise breathing techniques, or take up a new hobby or project.
Suggest healthy, crunchy snacks such as carrot sticks or celery to help with cravings and the increased hunger that
can be associated with tobacco cessation.
Counselling approaches for patients at various stages of change might include:
Precontemplation—Ask and Listen
Encourage patients to discuss their smoking openly and to think about quitting, e.g., “What do you like and not
like about smoking?”
Reinforce relevant health consequences of smoking, but avoid confrontational or judgmental comments or
body language.
When possible, use a personalized approach to initiating a dialogue, e.g., “I am concerned about the effect
smoking is having on your asthma. Would you be willing to discuss this at some point?”
Empower patients with belief in their ability to quit. Help them to remember what successes they have had in
the past, no matter how small, and focus on the positives, e.g., “During your last quit attempt, what went well
for you?” or “What is the longest time you have been able to remain smoke-free?”
Provide information and reassurance that you will be available to help when they are ready.
Contemplation—Motivate and Assist
Encourage patients to think about their own pros and cons for smoking versus quitting. Help them understand
that the benefits of quitting are well worth the challenge.
Be understanding if patients express ambivalence about quitting or seem discouraged from failed attempts to
quit in the past.
Provide encouragement and positive reinforcement of their desire to quit and reassurance about any perceived
deterrents, e.g., “It is great that you are thinking about quitting. That is the first step towards success. I know
you are concerned about gaining weight, but this is something that can be prevented. I can certainly help you
with this. Let me know when you are ready to talk more about it.”
Preparation—Show and Tell
Help patients set a quit date, ideally within the next 2 weeks. The patient may choose to quit abruptly on that
day with NRT or to gradually reduce cigarettes smoked to help minimize withdrawal before the quit date.37
Use the Modified Fagerström Nicotine Tolerance Scale (see Table 3) to assess nicotine dependence, then help
select the most suitable smoking cessation method.
Address questions/concerns about smoking cessation, e.g., nicotine withdrawal, nicotine replacement
products, triggers, past quit attempts, weight gain.
Prior to quitting, encourage patients to avoid smoking in places where a great deal of time will be spent such
as in the car or at home to help minimize the behavioural and psychological aspects of smoking.38
Suggest avoiding triggers by removing smoking paraphernalia, e.g., ashtrays and lighters from the home and
vehicles, and cleaning areas to remove the smell of smoke.
Suggest strategies to deal with cravings, e.g., remembering the reasons for quitting smoking, distractions such
as exercise, relaxation, taking deep breaths, low calorie snacks and seeking social support.
Encourage patients to identify and inform individuals they will count on for support during the quit process,
e.g., family, friends, co-workers.
Inform patients of community resources available to assist with smoking cessation such as quit lines (see
Table 4).
Action—Congratulate
Provide positive feedback and praise for taking the important step of quitting.
Ask patient about progress since your last visit, e.g., “How are you dealing with cravings? Have you had any
setbacks since we last spoke and if so how did they affect you?”
Reinforce coping strategies that were successful or suggest new ones if necessary.
Reassess medication use and suggest changes as appropriate.
Continue to provide support and follow up periodically.
Maintenance—Support
Continue to provide positive reinforcement.

Work to prevent relapse and encourage long-term self-management.
Remind patients of their own reasons for quitting and help demonstrate their success and progress, e.g., “You
know, you have barely needed your blue inhaler in the last few months. This tells me that your asthma is under
much better control since you quit smoking.”
Relapse—Don't Give Up
Remind patients that this situation should be considered a “learning experience” rather than a failure.
Find out what stage of change they are currently in and assist them with getting back into the preparation
stage.
Identify triggers for relapse and discuss strategies for prevention.
Help patients identify personal strengths and weaknesses and formulate a new plan of attack.
Motivate and encourage them to try again no matter what, e.g., “Quitting smoking is one of the most difficult
things to do and it often takes a few attempts before a person becomes completely smoke-free. With each
attempt, you are getting that much closer to quitting permanently. If you are willing to try again, we can
discuss. I am here to help.”
Motivational Interviewing
Motivational interviewing is a goal-orientated method used to motivate a patient to change behaviour. Although
there is a lack of evidence due to inconsistency and standardization issues, motivational interviewing can still be
a valuable tool when properly used, to assist a patient in overcoming barriers and making a commitment to
change.39
Some strategies and techniques in motivational interviewing include:
Open-ended questions: Engage the patient in open-ended questions to encourage elaboration and
discussion. For example, ask, “What do you like (or not like) about smoking?” or “What does your life look
like to you 10 years from now. Are you still smoking?”
Change talk: Engage patients in conversation that inquires about their own personal reasons for changing.
For example, ask, “Tell me your reasons for changing or quitting smoking. Why are these reasons important
to you?”
Reflective listening: Listen to patients and paraphrase their responses back to them to gain understanding
and perspective
Normalizing: Communicate to patients that the difficulties and barriers they may be facing are common for
someone at their stage of change
Summarizing: Summarize points that have been discussed, specific plans of action, and personal reasons
for taking that action.
For further information on motivational interviewing, see Resource Tips.
Behaviour Modification Programs
About 1 in 5 smokers preparing to stop smoking actually seeks formal help with quitting. Although smokers can
become involved in self-help programs, healthcare practitioners should be providing information on behavioural
interventions for all smokers, regardless of the patient's motivation to quit. For effective engagement strategies,
see Suggested Readings.
Even brief advice to quit from a primary care physician during a routine consultation has been effective in
increasing the number of smokers who remain abstinent for at least 6 months. Person-to-person counselling
over 4 or more sessions is especially effective. In general, greater contact between the patient and the program
provider leads to greater success.7,40
Regardless of their level of nicotine dependence, encourage patients to participate in a behaviour modification
program. Light smokers may be able to achieve lasting abstinence using behaviour modification alone, while
moderate to heavy smokers benefit from the addition of pharmacologic therapy. The combination of
pharmacotherapy and behaviour modification increases success rates in smoking cessation compared with
usual care.41 This further validates the importance of behaviour modification programs in addition to
pharmacotherapy.
Even the simplest type of behaviour modification programs may be beneficial. Self-help in the form of electronic
aids such as internet sites and text messages designed to assist individuals to stop smoking may be effective in
increasing the likelihood of long-term cessation.42,43,44
Support groups are more effective than self-help materials such as pamphlets or handouts, but more evidence is
needed to compare support groups with one-on-one counselling.45
Many self-help materials, individual and group programs, and counselling programs are available to both
healthcare practitioners and patients. A list of programs in each province is available on the Health Canada and
the Lung Association web sites (see Table 4).
To provide optimum support for smoking cessation, healthcare practitioners need proper training.46 The “5 A's
Approach” is a universally adopted tool healthcare practitioners often use as part of a smoking cessation
program. The 5 A's consist of: Ask, Advise, Assess, Assist and Arrange. Healthcare practitioners can be trained
in this approach via several programs including QUIT and TEACH (see Table 4).
Table 4: Smoking Cessation Programs and Resources
Program
Name Description Contact Information Cost
Canadian Mainly for 1-416-535-8501 (Ext. 7427) Freea

Action HCPs; user www.nicotinedependenceclinic.com/English/CANADAPTT/Pages/Home.aspx
Network for can post
the online (affiliated with CAMH)
Advancement, questions to
Dissemination panel
and Adoption experts or
of Practice- colleagues.
informed Quick
Tobacco reference to
Treatment guideline
(CAN- updates
ADAPTT)
Centre for Online www.camh.ca Freea

Addiction and information 1-416-535-8501 (Ext. 1600)
Mental Health for the public
(CAMH) on tobacco
use. HCP
education
programs
such as the
TEACH
project
Lung Tips for www.lung.ca/lung-health/smoking-and-tobacco/how-quit-smoking/choose-

Association quitting and support
listings of
local support
groups
Program
On the Road A 40-page Health Canada smoking cessation website Freea
to Quitting— self-help www.hc-sc.gc.ca/hc-ps/pubs/tobac-tabac/road-voie-eng.php
Guide to guide and
Becoming a online
Non-smoker program to
assist
smokers
with the
quitting
process
One Step at a Self-help Canadian Cancer Society Freea

Time—A program for 1-888-939-3333
Smoker's patients—
Guide to includes www.cancer.ca
Quitting books (For (also available through the Smoker's Helpline service)
Smokers
Who Want to
Quit and For
Smokers
Who Don't
Want to Quit)
and a
pamphlet for
assisting
others who
wish to quit
QUIT—Quit Training Canadian Pharmacists Association b

Using and program that 1-800-917-9489
Inhaling provides
Tobacco useful www.pharmacists.ca/quit
resources
and tools for
practising
pharmacists.
Live
workshops
and an
online
lesson are
available
Program
Smokers' Service www.smokershelpline.ca Freea
Helpline provided by Toll-free telephone numbers provided for each province and territory
trained
counsellors
to assist
patients who
are seeking
help with
smoking
cessation.
Telephone
assistance,
online and
print
materials
available in
French and
English
a Shipping costs may apply for large orders.

b
Fee for live and online workshops; resources free for participants.
Abbreviations: HCP = healthcare practitioner; TEACH = Training Enhancement in Applied Cessation Counselling and
Health
Acupuncture
Acupuncture therapy for smoking cessation is based on the Chinese concept of energy pathways in the body. It
involves special needles placed at strategic points under the skin of the nose or ear. Evidence of effectiveness in
smoking cessation is not available; most studies were poorly conducted, yielding unreliable results.47,48,49
Aversion Therapy
Aversion therapy is based on the concept that association of an unpleasant sensation with smoking can reduce
the desire to smoke. Techniques have included mild electric shock, breath-holding, rapid smoking, unpleasant
taste, noise or smell, and imagined stimuli. Good evidence to support aversion techniques is lacking; rapid or
excessive smoking has shown the most promise; however, due to the potentially harmful effect on the heart and
lungs, this method is not recommended as a smoking cessation strategy.47,49
Clove and Herbal Cigarettes
Imitation cigarettes containing ingredients such as cloves and various herbs are available. However, these
products may also contain tar, carbon monoxide and various other toxins. Clove cigarettes may actually contain
up to 70% tobacco, providing nicotine and the same toxins as all-tobacco cigarettes.50,51
Electronic Cigarettes
Electronic cigarettes contain a battery-powered mechanism to heat and vapourize a liquid chemical mixture
composed of varying amounts of nicotine, propylene glycol, other chemicals and/or impurities. The vapour
produced resembles the smoke of an actual cigarette, which may satisfy the behaviours associated with
smoking (handling of cigarette, inhaling of smoke) in addition to nicotine addiction. Advocates of e-cigarettes
praise them as a clean drug delivery device, although the chemical safety is unknown. For example, propylene
glycol is a known irritant and the long-term effects on the lungs are unknown at this time.52 Additionally, the FDA
conducted a preliminary analysis on samples of e-cigarettes from leading brands and found known carcinogens
and toxic chemicals.53 Although the analysis conducted was preliminary, it illustrates the lack of research on
these products and the need for additional data on safety and effectiveness.
Electronic cigarettes are currently sold in Canada and are also available via the internet. However, since the
production is not regulated, some electronic cigarettes contain nicotine while others contain varying levels of
other chemicals. It is important to note that only those products without nicotine or health claims can be legally
imported and sold in Canada.54 Over 400 brands of electronic cigarettes are available.53 There is world-wide
debate concerning electronic cigarettes, since the potential benefit of smoking cessation may outweigh the
potential risks. Current evidence does not support the use of electronic cigarettes for smoking cessation.55,56
Health Canada does not recommend using electronic cigarettes due to lack of safety information regarding
exposure to vapourized propylene glycol (among other chemicals used in the products) and their unknown long-
term effects.54
Financial Incentives
Financial incentives are being used more frequently to encourage people to quit smoking. Although there has
been some success with improved abstinence rates in the short term, the long-term (>12 months) efficacy of
these strategies is yet to be determined.57 Further research is required.58,59 One population that may respond to
financial incentives is pregnant women. See Pregnancy for more information.
Hypnosis
Hypnosis is a deep, relaxed state of attention during which people are more responsive to suggestions.
Hypnotherapy for smoking cessation attempts to change a person's habits and attitudes to cigarettes. The
therapist's skill and experience are very important, as are the patient's susceptibility to hypnosis and desire to
quit. Although there are reports of success with this method, a Cochrane review concluded there was
insufficient evidence to consider hypnotherapy effective for smoking cessation.48 If this method is tried, advise
patients to combine it with behaviour modification or counselling. Follow-up counselling and support or
combining the therapy with other smoking cessation methods may also improve the success of
hypnotherapy.47,49,60
Laser Therapy
Similar to the application of acupuncture, laser therapy uses laser beams which are directed at certain key
points on the body surface. This stimulation of key points purportedly triggers a release of endorphins and
relieves nicotine cravings. No reliable studies support this therapy.47,48,49
Pharmacologic therapy for smoking cessation can be divided into 2 broad categories: nicotine replacement therapy
and non-nicotine therapies.
The purpose of pharmacologic therapy is to reduce the physical effects of nicotine withdrawal (see Table 1), which
peak within 72 hours and may continue intermittently for several weeks. In some patients, pharmacologic therapy is
also needed to reduce the psychological effects of withdrawal (cravings), which can last up to several years, or as
some ex-smokers will attest, indefinitely.4,5 While many patients may benefit from pharmacologic therapy, patients
who are only mildly addicted may not require it to quit successfully. Pharmacotherapy may be contraindicated for
certain patients because of potential drug or disease interactions.
Determining the most effective therapy from published studies is difficult. Varenicline, NRT and combination NRT
have been found to be comparable at increasing the likelihood of a successful quit attempt.61 Other assessments
have shown varenicline to be superior to the nicotine patch but comparable to combination NRT.62 Bupropion is
generally thought to be less effective than varenicline, but has been found to be comparable to the patch alone.63
Some of the difficulty in interpreting results of studies is due to variations in study design and population, and
differences in the definition of abstinence. All available therapeutic options increase the chances of a successful
quit attempt. Recommend the form of therapy that is most appropriate and acceptable to the patient.
Alternative agents that are effective but with more side effects or less evidence are clonidine, nortriptyline and
cytisine.62
Nicotine Replacement Therapy
Nicotine replacement therapy (NRT), designed to replace the nicotine found in cigarettes, is the mainstay of
nonprescription therapy for smoking cessation. In Canada, NRT medications are considered unscheduled
products and can be obtained from any retailer without a prescription. Available dosage forms include chewing
pieces (gum), lozenges, inhalers, mouth sprays and transdermal patches (see Table 8). Nasal sprays and
sublingual tablets are not available in Canada.
Nicotine replacement therapy increases abstinence rates by 50–70 percent.64 The success of NRT is
independent of dosage form, concurrent therapy and setting.
In general, the incidence of adverse effects with NRT is low provided the patient receives adequate counselling
on the appropriate use of the product. It is important to consider that some contraindications may be relative
rather than absolute contraindications, requiring clinical judgment in the decision-making process. Given the
significant risks of continued smoking, the risk/benefit ratio for pharmacotherapy may be favourable even in
pregnant patients or those with heart disease. These patients can often be successfully and safely managed
with NRT or other pharmacotherapy under guidance of their healthcare practitioner or specialist. See Special
Considerations.65
Ailments—Smoking Cessation Products.
Combination NRT
The combination of nicotine patch with as-needed gum, inhaler or lozenges may be more effective than the
individual products, possibly because it provides a steady baseline level of nicotine with “boluses” for
flexibility and treatment of cravings.7,63,64 One study comparing combination NRT to NRT patch alone and
varenicline found no difference in long-term quit rates of about 20% for all therapies.61
For heavy smokers who continue to suffer withdrawal symptoms despite indicated doses, i.e., a single
nicotine patch, it is common practice to increase the total daily nicotine doses by use of combinations of
NRT products. Off-label uses include total daily doses of nicotine up to 35 mg per day for smokers previously
using 21–40 cigarettes a day, and up to 40 mg per day for smokers previously using more than 40 cigarettes
a day, with reported safety and improved efficacy.66,67,68 These doses may be achieved by using additional
patches or fast-acting nicotine, e.g., gum, inhaler, lozenge or spray, or a combination of patch and fast-acting
products. Using more than 1 patch or total daily doses >30 mg requires appropriate healthcare practitioner
supervision.
Further studies are needed to define the ideal candidates for combination therapy. In practice, it would be
reasonable to provide combination NRT to smokers who have struggled with NRT patches or other single
forms.
Non-nicotine Pharmacotherapy
A number of non-nicotine therapeutic agents have been investigated for use in smoking cessation.
Bupropion is effective for smoking cessation.7,69 Contraindications include a history of seizures, anorexia or
bulimia nervosa and concurrent MAOI therapy. More common adverse effects include dry mouth and insomnia.
Less common are hypertension, arthralgia, myalgia, dizziness, tremor, somnolence, bronchitis, pruritus, rash and
taste perversion.70 Some patients may develop agitation-like behavioural or emotional changes, which may
increase the rare risk of harm to themselves or to others. Close patient monitoring is advised for all patients, but
especially in those with underlying psychiatric illness.70
As with other pharmacotherapeutic agents for smoking cessation, bupropion should be used in combination
with behavioural programs to assist the quitting process, and can be used during pregnancy if benefit outweighs
the risk.70
Varenicline is an alpha4beta2-nicotinic receptor partial agonist used to assist patients with smoking cessation.7
It also may be an option for smokers who are unable to abruptly stop smoking. One study has shown that
among cigarette smokers who are not willing or able to quit but are willing to reduce the number of cigarettes
smoked, varenicline used for 24 weeks significantly increased cessation rates (27%) compared with placebo
(9.9%).71 Patients should be advised about common side effects such as nausea, vomiting, headache, insomnia,
abnormal dreams and dizziness.
Concerns regarding potential cardiovascular risks of varenicline72,73 prompted Health Canada to review its
cardiovascular safety.74 The review drew no firm conclusions due to small study populations available at the
time.75 Subsequent analyses, including a meta-analysis of 18 clinical trials, suggested no significant increase in
cardiovascular adverse events associated with varenicline use.76,77,78 It still may be prudent to cautiously
assess patients before initiating therapy in those with cardiovascular concerns.
Safety concerns have also been raised regarding neuropsychiatric symptoms. Investigations into concerns
regarding severe behavioural changes, e.g., suicidal ideation, depression or suicide attempt, have found no
increase in these events in patients on varenicline compared with placebo.79,80 One study confirmed the lack of
association but found a small increase in anxiety and mood conditions only in persons with pre-existing
psychiatric disorders.81 Regardless of therapy being used for smoking cessation, psychological changes should
be monitored with every patient.82
Varenicline is contraindicated during pregnancy as there is evidence of reproductive toxicity in animal studies,
though no human pregnancy data are available.83
Nortriptyline is a treatment option that has been shown to aid long-term smoking cessation. As with bupropion,
the mode of action of nortriptyline is independent of its antidepressant effects and it has similar efficacy to
NRT.69 Clonidine is somewhat effective but of limited use because of significant side effects.7,62,84,85 See Table
9.
Although it is not currently available in Canada, cytisine, a partial agonist that binds the nicotinic acetylcholine
receptor, has been found to be superior to NRT when combined with brief behavioural support. Its use is limited
by frequently reported adverse events.86
Combination Therapy
Despite concerns over additive side effects, such as nausea, headache or dyspepsia when combining
varenicline with NRT, the combination was found to be well tolerated in 2 separate studies.87,88 These 2
studies yielded contradictory results. One study found the combination to be superior to varenicline alone for
cessation rates;88 the other found no benefit.87 Further studies are needed to assess long-term efficacy and
safety of the combination.
The combination of varenicline and bupropion was studied in a group of people who were unable to reduce
their smoking by at least 50% after 1 week of NRT.89 Compared with varenicline alone, subjects taking
varenicline plus bupropion were more likely to be smoke free at 8–11 weeks. The combination was
statistically superior in men, but not in women. Smokers with high nicotine dependence were also more likely
to be successful on the combination. This study was of short duration, but suggests that the combination is
safe and may be effective for select smokers. Further studies are needed to better define the role of this
combination.
Bupropion combined with NRT has been studied with mixed results. One study found higher quit rates in the
combination group, but the difference was not statistically significant.90 Another study found no difference
among bupropion monotherapy, NRT monotherapy or the combination.91 A third study in patients with
schizophrenia found the combination of bupropion and high-dose NRT had greater abstinence rates while
using bupropion and high-dose NRT compared with placebo and high-dose NRT, but relapse rates were high
and no difference in cessation rates was found at 1 year. This study was small and may have lacked
statistical power to detect a true difference.92 Based on the currently available evidence, the combination of
bupropion and NRT cannot be recommended for routine use.
Special Considerations
Special Considerations
Pregnancy
Nonpharmacologic choices are always first-line for pregnant patients, as behavioural therapy has proven
effective for smoking cessation in pregnancy.93 Financial incentives such as shopping vouchers demonstrated
substantial evidence of efficacy for smoking cessation in pregnancy.94 Psychosocial interventions such as
social support and counselling can increase the proportion of pregnant women who stop smoking which will
help reduce the risk of low birth weight and preterm birth.
Evidence is insufficient to determine whether NRT is effective or safe for smoking cessation in pregnancy.95
Women with moderate to high nicotine dependence will likely require some form of pharmacotherapy.7 One
must balance the risks of continuing to smoke with the risks of using NRT. The products are not officially
approved for use in pregnancy and NRT may have potential risks to the mother and fetus;7,96 however, cigarette
smoking during pregnancy may have far greater risks including exposure to the 4000 other chemicals in tobacco
smoke. Most experts believe that if nonpharmacologic and/or behavioural strategies fail, interventions with NRT
would be justified and can be attempted with close supervision by an appropriate healthcare practitioner. It is
important to incorporate behavioural interventions and to use the lowest effective dose of NRT. Initiation of
smoking cessation is important during the earlier stages of pregnancy, ideally within the first 16 weeks.
Evidence shows that nicotine patches do not have a lasting effect on smoking cessation in pregnancy compared
with placebo; however, use of NRT patches during pregnancy resulted in lower incidence of developmental
impairment in the offspring at 2 years, compared with placebo.97,98 Further research is required to determine
the safety and efficacy of NRT use in pregnancy.
If NRT is to be used in pregnancy, an immediate-release form of NRT such as the gum, lozenge or inhaler may be
preferred over a continuous dosage form such as the patch. Use the lowest effective dose, for the shortest
possible time, to reduce fetal exposure to nicotine. If a patient is highly addicted to nicotine, use of the patch
may be necessary. In these cases, use of a patch during waking hours only (e.g., a 24-hour patch applied for 16
hours and removed at night) can reduce fetal nicotine exposure. Close supervision and monitoring is essential
for all pregnant patients and should involve the patient's physician.
Breastfeeding
Nicotine is excreted in breast milk when NRT is used. The risk to the infant for NRT-related nicotine exposure is
lower than the risk from second-hand smoke, such as increased risk of sudden infant death syndrome,
respiratory infections or asthma.7 Intermittent use of immediate-release forms of NRT are preferred in
breastfeeding mothers. Encourage the mother to breastfeed just before using the NRT product, to minimize
infant exposure to nicotine.96
Cardiovascular Disease
It is dangerous for patients with cardiovascular disease to continue to smoke. Smoking can activate coagulation
pathways in the body, promoting thrombus formation and increasing the risk of myocardial infarction. Nicotine
can also cause vasoconstriction as well as increased heart rate and contractility.2 Despite this, many experts
now believe that short-term use of NRT is safer than smoking, although there are risks involved with the use of
NRT products. Evidence suggests that NRT is generally safe in patients with stable cardiovascular disease.99,100
Caution and supervision by an appropriate healthcare practitioner are recommended, particularly within 2 weeks
following myocardial infarction or in patients with unstable angina or serious arrhythmias.7,101 The transdermal
patch may be preferable to immediate-release dosage forms because of more consistent nicotine plasma
concentrations.
Older Adults
Although damage to the lungs cannot be reversed, quitting smoking can extend the time to disability or death
regardless of age or smoking history.102 Even at older ages, smoking cessation is beneficial for reducing
cardiovascular risk.103 Improvements in health from smoking cessation are achievable in older adults, making it
critical to emphasize to patients that it is never too late to quit. The loss of lung function is not reversed but it
can be slowed with successful cessation. Even at advanced ages, smokers who quit can slow the decline in
function and reduce morbidity. See Figure 1 for an illustration of the impact of smoking cessation on FEV1 at
various ages. NRT remains the therapy of choice in older adults due to experience and limited evidence showing
efficacy.104 Further research in this population is needed to compare NRT with other therapeutic options such as
varenicline and bupropion.
Figure 1: Impact of Smoking Status on Lung Function Over Lifetime
Adapted from Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977;1(6077):1645-8, with permission of BMJ
Publishing Group Limited.
Children and Adolescents
Tobacco use is a major concern in the pediatric population.7 Experimentation with nicotine and drugs begins
ages 11–17 years or earlier in some cases. Nicotine dependence can occur rapidly in this population. Primary
prevention is key and healthcare practitioners must deliver strong messages of prevention and cessation to this
group and their parents.105 Adolescents are interested in quitting. A survey of about 5000 eleventh grade
students revealed that approximately 79% would be willing to discuss or acknowledge their smoking habit if they
were asked about it.7 This sets the stage for healthcare practitioners to engage in tobacco use discussion—
simply by asking the 3 main assessment questions (see Patient Assessment). Many patients may not be ready
to quit at the first visit but a strong message from a healthcare practitioner regarding tobacco abstinence and/or
cessation to young patients and their parents is important in the prevention of youth tobacco use.
The current recommendation for smoking cessation in adolescent smokers focuses on behavioural approaches.
Recommend Health Canada's “Quit4Life” program to this age group (see Table 4). Avoid incentive programs that
use prizes aimed at prevention of smoking. They are not effective in adolescents.106 Although NRT has been
shown to be safe in this population, it is generally not recommended. Counselling is the most effective
approach. There is little evidence that pharmacotherapy is effective in promoting long-term abstinence rates in
younger patients.7 When pharmacologic therapy (including NRT) is required in patients under 18 years of age, it
should be initiated and monitored by a healthcare practitioner.
Smokeless Tobacco
Discontinuation of smokeless tobacco products in post-MI patients was associated with an almost 50%
reduction in mortality, similar to the benefit seen with smoking cessation.107 This finding emphasizes the
importance of encouraging users of smokeless tobacco to quit. Counselling is effective for treating patients
who use smokeless tobacco products and should be considered first-line.7,108 Bupropion and nicotine
replacement therapy (NRT) have not demonstrated long-term abstinence rates for smokeless tobacco
cessation; however, NRT can be used in the short-term to alleviate nicotine withdrawal symptoms. Varenicline is
an effective pharmacologic choice for tobacco abstinence in smokeless tobacco users.109 High-dose NRT and
combination therapies have not yet been studied in these patients.108
Table 5 can be used to estimate the equivalent number of cigarettes to smokeless tobacco consumption. The
healthcare practitioner can then recommend a trial dose of NRT therapy if that is the chosen pharmacotherapy.
110
Table 5: Smokeless Tobacco, Cigarettes and Nicotine Patch: Conversion and Dosing Chart
Pinches of Number of Cans of Number of Suggested Nicotine Patch
Smokeless Tobacco Tobacco/Week Cigarettes Starting Dose
1 3–4 7 mg daily
2 6–8
3 1 9–11 14 mg daily
4 12–14
5 15–17
6 2 18–20 (1 pack) 21 mg daily
13 4 39–41 (2 42 mg daily
packs)
20 6 60–62 (3
packs)
26 8 78–80 (4
packs)
Drug Interactions
Cigarette smoking can affect the metabolism of many drugs. A major carcinogen found in tobacco smoke,
polycyclic aromatic hydrocarbons (PAH), is responsible for induction of hepatic enzymes CYP1A1, 1A2, and
possibly 2E1.111 CYP1A2 is the main pathway affected.
The effect on drugs of enzyme induction can take a couple of weeks to manifest. The clearance of drugs such
as caffeine, clozapine, fluvoxamine, olanzapine, opioid analgesics, and warfarin may be increased in smokers.
For example, plasma clozapine concentrations can increase by 72% on average when a patient stops smoking,
due to decreased clearance.112 Furthermore, smokers may require higher doses of warfarin, up to an additional
2.26 mg per week, compared with non-smokers, due to CYP1A2 induction.112 [Evidence: SORT C] As a result,
INR should be monitored more frequently when a patient quits smoking.
Monitoring drug therapy is essential and dosage reduction may be required upon smoking cessation.111,112
[Evidence: SORT C] Assess for drug interactions or refer patients to an appropriate healthcare practitioner if they
are taking drugs that may be affected by smoking and are planning to quit. Reduction of caffeine intake is
advised to minimize caffeine-induced palpitations, agitation and other side effects during and after the quit
attempt. Potential interactions involving tobacco smoke are listed in Table 6.
Nicotine does not induce enzymes so drug interactions occur with tobacco smoke but not with NRT.
111,113,112
Table 6: Drug Interactions with Tobacco Smoke
Drug/Class Suggested Clinical Management
acetaminophen When patient stops smoking:
caffeine
clozapine
diazepam
estrogens
Drug/Class Suggested Clinical Management
fluvoxamine
Consider decreasing dose based on clinical and
methadone
adverse effects. Clinical management requires
nifedipine individualization of approach based on needs and
olanzapine response of the patient.
opioid analgesics (e.g., oxycodone, Recommend decreasing caffeine intake by 50% upon
codeine) initiation of cessation attempt.
rasagiline
When patient starts smoking:
theophylline
warfarin Consider increasing dose if clinical effect appears to
be lessened. Clinical management requires
individualization of approach based on needs and
response of the patient.
Because of the large behavioural component of smoking cessation, monitoring of therapy is crucial to success.
Ideally, the patient receives ongoing monitoring for a period of time by a clinician or therapist involved with a
smoking cessation program (see Table 7). If monitoring is not available from the program, healthcare practitioners
should offer it.
a
Table 7: Monitoring of Therapy for Smoking Cessation
Parameter Indicators/Goal/ Suggested Recommended Intervention
Time Frame Monitoring
Frequency
Smoking Patient reports no Patient: Daily Inquire about amount smoked; provide
smoking. Healthcare encouragement and support.
practitioner: If patient has a relapse, discontinue nicotine
Monthly × 3 replacement therapy until patient is ready to
months then at quit again; encourage patient to reset a quit
6 and 12 date; discuss possible reasons for relapse
months and help patient strategize about how to be
more successful with the next quit attempt;
be empathetic and avoid scolding the patient.
Desire to Patient reports level of As above Intense craving may require alternate
smoke desire decreasing to treatment (see Table 8 and Table 9).
minimal (or none) by Encourage behavioural changes to decrease
end of therapy (3–6 desire; empathize with patient's difficulty and
months); cravings may strongly encourage perseverance.
never completely end
for some.
Nicotine Patient on NRT reports As above If symptoms are bothersome, consider

withdrawal reduction in withdrawal increasing dose of NRT if using, switching to
symptoms symptoms (see Table or adding an alternate therapy (see Table 8
1) within 25 min to 24 and Table 9).
h of initiating therapy. Remind patients that the most difficult period
is the first 2–14 days. Recommend additional
behavioural interventions if necessary.
Parameter Indicators/Goal/ Suggested Recommended Intervention
Time Frame Monitoring
Frequency
Medication Patient reports no As above If minor side effects occur, suggest ways to
adverse adverse effects when modify, e.g., for belching, hiccoughs and GI
effects questioned specifically upset with gum, advise proper chewing
throughout duration of technique, or consider switching to an
pharmacotherapeutic alternative method of NRT.
treatment. If serious adverse effects occur, (e.g.,
hypertension, nicotine toxicity, mood changes,
seizures) consider reducing dose or
discontinuing medication and/or switching to
alternate therapy (see Table 8 and Table 9).
Weight Patient reports Patient: Weekly Encourage healthy eating habits, exercise,
gain114,115 minimal or no weight Healthcare healthy snacks to deal with cravings, e.g.,
gain over the 6–12 practitioner: 3, carrot sticks, to prevent or minimize weight
months following 6, 9, 12, 18 and gain. Reassure patient that slight weight gain
quitting. 24 months is less harmful to their health than continued
smoking.
Stress Patient reports Patient: Daily Assess for evidence of excessive stress, e.g.,
minimal additional Healthcare weight loss, nervous habits, GI symptoms,
stress due to smoking practitioner: 3, headache.
cessation over 6–12 6, 9, 12, 18 and Suggest behavioural therapy, e.g., deep
months following 24 months breathing, muscle relaxation, positive self-talk,
quitting. or refer to stress management program.
Encourage exercise and other distracting
activities.
Treat stress-related symptoms as needed
(recommend appropriate medication to
reduce stress or treat stress-related physical
symptoms).
Mood Patient reports Patient: daily Assess for any signs of depression, severe
minimal mood Healthcare agitation or mood changes. Family and/or
changes due to practitioner: 3, caregivers should be informed and alerted to
smoking cessation. 6, 9, 12, 18 and watch for these changes or symptoms.
24 months
a
List of monitoring parameters is not exhaustive. Parameters should be tailored to individual patient.
Abbreviations: NRT = nicotine replacement therapy
Relapse rates are high, particularly at the beginning of smoking cessation attempts, with 66% of patients reportedly
relapsing within 48 hours and 76% within the first week of unassisted quit attempts.7 Follow up should begin within
the initial week following the quit date, particularly if the patient is receiving NRT, to avoid adverse effects from
excessive nicotine levels. Follow-up counselling should be provided regularly, e.g., every month for 3 months, then at
6 and 12 months. In general, more counselling time yields higher abstinence rates.7 Additional monitoring should be
considered for patients who are at high risk, e.g., highly nicotine-addicted patients with history of many previous
smoking cessation attempts, patients experiencing severe psychosocial stress, those with comorbid substance
abuse disorders or history of depression or schizophrenia, patients taking concomitant medication that interacts
with nicotine, or cases where smoking cessation is medically urgent. A suggested schedule for more intensive
monitoring might involve follow up every 2 weeks for the first 3 months, then at 6, 9, 12, 18 and 24 months.
Algorithms
Figure 2: Assessment of Patients with Nicotine Dependence

Abbreviations: CAD = coronary artery disease; COPD = chronic obstructive pulmonary disease; HCP = healthcare
professional; NRT = nicotine replacement therapy
Drug Tables
Table 8: Nicotine Replacement Therapy for Smoking Cessation
Drug/Costa Dosage Adverse Contraindications Comments

Effects
Drug Class: Nicotine replacement, immediate-release

Effects
nicotine Initial strength: Jaw, mouth or Life-threatening Caution

gum/chewing Nicorette: 2 mg if throat soreness. arrhythmia; severe patients not to
pieces (nicotine Fagerström score is CNS: angina pectoris; chew like
polacrilex) ≤6, 4 mg if ≥7 (see depression, history of recent regular gum
Nicorette Gum, Table 3). anxiety, stroke; (increased
Nic-Hit Gum, Thrive: 4 mg if ≥25 irritability, temporomandibular side effects).
Thrive, generics cigarettes/day, 2 mg if insomnia; joint disease; within Avoid use of
<25 cigarettes/day dizziness, 2 wk following acidic
$ Initial dose: 10–12 myocardial
weakness, beverages and
pieces per day po; headache. infarction. foods (coffee,
may increase to 20 Relative fruit juices,
pieces per day if Gastrointestinal:
changes in contraindications: soft drinks,
needed pregnancy, smoking alcohol) while
Place 1 piece of gum taste
perception, while using this chewing and
in the mouth. Bite medication (nicotine 15 min before
down once or twice hiccoughs
dyspepsia, toxicity), as this
then park it between breastfeeding, age decreases
the teeth and gums nausea,
vomiting. <18 y. absorption.
for about 1 min.
Repeat when the Cardiovascular: Caution in Favourable
desire to smoke arises hypertension, hyperthyroidism, dosing
or once the ‘tingling’ palpitations, pheochromocytoma, flexibility
sensation stops, up to tachycardia, insulin-dependent compared
once per min for up to chest pain. diabetes, active with patch.
30 min, then discard peptic ulcer,
Skin: erythema, uncontrolled
piece
itching, rash, hypertension.
At weekly intervals,
urticaria.
reduce by 1 piece/day
over 3 months, as Respiratory:
withdrawal symptoms dyspnea, cough,
allow. Continue for hoarseness,
maximum of 6 sneezing,
months wheezing.
Peak: 20–30 min
Effects
nicotine Initial strength: 1 mg if Jaw, mouth or Life-threatening Caution

lozenges(nicotine <20 cigarettes per day, throat soreness. arrhythmia; severe patients not to
bitartrate 2 mg if ≥20 cigarettes CNS: angina pectoris; swallow or
dihydrate) per day depression, history of recent chew
Thrive Lozenges Dosing frequency: see anxiety, stroke; lozenges
nicotine polacrilex irritability, temporomandibular (increased
$ lozenges; maximum joint disease; within side effects).
insomnia;
15/day po for 2 mg dizziness, 2 wk following Avoid acidic
strength, 25/day po weakness, myocardial beverages and
for 1 mg strength headache. infarction. foods (e.g.,
Peak: 20–60 min Relative coffee, fruit
Gastrointestinal:
changes in contraindications: juices, soft
taste pregnancy, smoking drinks,
perception, while using this alcohol)
hiccoughs medication (nicotine during and 15
dyspepsia, toxicity), min prior to
nausea, breastfeeding, age using the
vomiting. <18 y. lozenge as
Caution in this decreases
Cardiovascular: absorption.
hypertension, hyperthyroidism,
palpitations, pheochromocytoma, Favourable
tachycardia, insulin-dependent dosing
chest pain. diabetes, active flexibility
peptic ulcer, compared
Skin: erythema, uncontrolled with patch.
urticaria.
Respiratory:
dyspnea, cough,
hoarseness,
sneezing,
wheezing.
Effects
nicotine Use initial strength of Jaw, mouth or Life-threatening Caution

lozenges(nicotine 2 mg if first cigarette throat soreness. arrhythmia; severe patients not to
polacrilex) of the day >30 min CNS: angina pectoris; swallow or
Nicorette after waking, 4 mg if depression, history of recent chew
Lozenge, Nic-Hit ≤30 min anxiety, stroke; lozenges
Mini-Lozenge Weeks 1–6: Dissolve 1 irritability, temporomandibular (increased
lozenge in the mouth insomnia; joint disease; within side effects).
$$ Q1–2H PRN for 2 wk following
dizziness, Avoid acidic
withdrawal symptoms weakness, myocardial beverages and
(maximum 15 headache. infarction. foods (e.g.,
lozenges/day) Relative coffee, fruit
Weeks 7–9: Use 1 Gastrointestinal:
changes in contraindications: juices, soft
lozenge Q2–4H PRN pregnancy, smoking drinks,
po taste
perception, while using this alcohol)
Weeks 10–12: Use 1 medication (nicotine during and 15
lozenge Q4–8H PRN hiccoughs
dyspepsia, toxicity), min prior to
po breastfeeding, age using the
Discontinue when the nausea,
vomiting. <18 y. lozenge as
dose has been this decreases
reduced to 1–2 Cardiovascular: Caution in
hyperthyroidism, absorption.
lozenges/day hypertension,
Use beyond 6 months palpitations, pheochromocytoma, Favourable
is not generally tachycardia, insulin-dependent dosing
recommended chest pain. diabetes, active flexibility
Lozenges should be peptic ulcer, compared
Skin: erythema, uncontrolled with patch.
allowed to slowly
dissolve and moved
urticaria.
from one side of the
mouth to the other Respiratory:
periodically dyspnea, cough,
Peak: 20–60 min hoarseness,
sneezing,
wheezing.
Effects
nicotine inhaler Initial therapy: Use at Mainly mild Life-threatening Each 10 mg

Nicorette Inhaler least 6 cartridges/day local irritation, arrhythmia; severe cartridge
(maximum 12 per day) cough, throat angina pectoris; delivers 4 mg
$$ for the first 3–6 wk. irritation, history of recent of nicotine (of
Begin to taper slowly pharyngitis, stroke; which about 2
over the next 6–12 stomatitis, temporomandibular mg is
wk. Discontinue once rhinitis. joint disease; within systemically
usage is down to 1–2 Headache, 2 wk following absorbed);
times per day (after 3 dyspepsia, myocardial approximately
months ideally). Use nausea may infarction. equivalent to
may be continued with also be present. Relative 20 min of
tapering dosage up to Side effects are contraindications: puffing.
6 months. Use for >6 usually transient pregnancy, smoking Nicotine
months not and decrease while using this vapour is
recommended with continued medication (nicotine absorbed
Inhalers should be use. toxicity), through the
puffed similarly to a breastfeeding, age buccal lining
cigarette (~5–10 min <18 y. of the mouth,
at a time) not from the
Peak: 15 min Caution in
hyperthyroidism, lungs.
pheochromocytoma, Colder
insulin-dependent ambient
diabetes, active temperatures
peptic ulcer, decrease
uncontrolled absorption
hypertension. rate.
Cartridge can
be used for up
to 24 h once
punctured.
Effects
nicotine Use 1 or 2 sprays Altered sense of Life-threatening Each spray

mouthspray every 30–60 min po taste, headache, arrhythmia; severe delivers 1 mg
Nicorette Maximum dose: 2 hiccoughs, angina pectoris; of nicotine.
QuickMist, Nic- sprays/episode, 4 nausea and history of recent Mouthspray
Hit Spray sprays/h, 64 vomiting, stroke; absorbed
sprays/day dyspepsia, oral temporomandibular through
$$ Spray must be primed soft tissue pain, joint disease; within buccal
with first use or after 2 stomatitis, 2 wk following mucosa.
days of not using salivary myocardial
Peak: 16 min hypersecretion, infarction. Avoid acidic
burning lips, dry beverages and
Relative foods (coffee,
mouth. contraindications: fruit juices,
pregnancy, smoking soft drinks,
while using this alcohol)
medication (nicotine during use
toxicity), and 15 min
breastfeeding, age before use as
<18 y. this may
Caution in decrease
hyperthyroidism, absorption.
pheochromocytoma,
insulin-dependent
diabetes, active
peptic ulcer, GI
disease,
uncontrolled
hypertension,
hepatic or renal
impairment.
Drug Class: Nicotine replacement, sustained-release

Effects
nicotine Apply patch to Local skin Life-threatening Assess

transdermal nonhairy, clean, dry reactions: arrhythmia; severe patient in first
patch skin site on upper arm erythema, angina pectoris; 2 wk to ensure
Habitrol, or hip; use a different pruritus, edema, history of recent smoking has
Nicoderm, site each day; avoid blisters, rash, stroke; been
generics using the same site burning temporomandibular discontinued.
more than once sensation. joint disease; within Wearing patch
$$$ weekly 2 wk following
CNS: headache, during
Apply upon waking dizziness, myocardial strenuous
and wear 16–24 h per paresthesias, infarction; exercise may
day, depending on insomnia, generalized skin increase
product abnormal disorders (severe absorption
General dosing dreams, eczema or and adverse
instructions involve 6 depression, psoriasis); effects.
wk of use of highest somnolence, hypersensitivity to
strength (21 mg for topical adhesives or Used patches
anxiety, should be
Nicoderm or Habitrol, emotional nicotine.
15 mg for Nicorette) folded so that
lability. Relative medicated
followed by 2 wk at contraindications:
the intermediate Cardiovascular: sides are
palpitations, pregnancy, smoking facing inward
strength then 2 wk at while using this
the lowest strength chest pain, and discarded
blood pressure medication (nicotine safely out of
Consult individual toxicity),
product monographs changes, reach of
tachycardia. breastfeeding, age children or
for details <18 y; mild atopic or
Peak: 2–6 h Gastrointestinal: pets.
eczematous
abdominal pain, dermatitis. Manufacturers
dyspepsia, do not
nausea, Caution in recommend
diarrhea, hyperthyroidism, cutting
constipation, pheochromocytoma, patches as
dry mouth, insulin-dependent this may
nausea and diabetes, active damage the
vomiting, peptic ulcer, delivery
flatulence, uncontrolled device.
stomatitis. hypertension.
Patients who
Respiratory: experience
cough, insomnia from
pharyngitis, the 24-hour
rhinitis, patch may
dyspnea, benefit from
sinusitis. removing the
Other: myalgia, patch at night
arthralgia, and using an
dysmenorrhea, immediate-
toothache, release
sweating, taste product first
perversion. thing in the
morning, then
applying a
new patch.
a Cost of 100 pieces of gum or lozenges, 42 cartridges, 150 sprays or 28 patches; includes drug cost only.
Legend: $ < $25 $$ $25–50 $$$ $50–75

Table 9: Non-nicotine Therapy for Smoking Cessation
Drug/Costa Dosage Adverse Effects Drug Comments

Interactions
Drug Class: Alpha2-adrenergic Receptor Agonists
clonidine 0.1 mg BID po starting up to Common: Avoid Monitor blood

generics 3 days before or on the quit sedation, concurrent use pressure and
date. Titrate up by 0.1 dizziness, with tricyclic heart rate
$ mg/day po once per week as hypotension, dry antidepressants. during
tolerated to a maximum of mouth. Less Additive effects treatment
0.4 mg/day. Duration of common: anxiety, with other CNS initiation.
therapy ranges from 3–10 irritability, memory depressants Taper
wk problems. such as ethanol. gradually to
Additive avoid rebound
hypotensive hypertension
effect when when stopping
combined with treatment.
antihypertensive
drugs.
Drug Class: Antidepressants
bupropion 150 mg daily po × 3 days Usual: insomnia, Inhibits CYP2D6; Not

Zyban then 150 mg BID po × 7–12 dry mouth, may decrease recommended
wk dizziness, clearance of in patients
$$$ Begin 1–2 wk before the restlessness, atomoxetine, with
selected quit date difficulty duloxetine, conditions
concentrating. fluoxetine, predisposing
Unusual: fluvoxamine, to seizures,
hypersensitivity paroxetine, history of
reactions, risperidone, seizures,
increased risk of sertraline, current eating
seizures at higher venlafaxine; may disorder or
dosages; agitation- decrease severe hepatic
type reactions effectiveness of impairment.
involving codeine and Least
mood/behavioural tamoxifen. expensive of
changes. Do not use with oral
MAO inhibitors medications.
(possible mania, Officially
excitation, indicated for
hyperpyrexia). smoking
May be safely cessation.
combined with
NRT (monitor for
treatment-
emergent
hypertension).
nortriptyline 25 mg/day po titrated to 75– Common: dry Do not use with Not
Aventyl 100 mg/day po mouth, blurred MAO inhibitors recommended
Quit day is usually set vision, (may cause in patients
$$ between 1 and 4 wk; constipation, mania, with
medication is continued for dizziness, excitation, conditions
12 wk sedation. hyperpyrexia). predisposing
Less common: Inducers of to seizures,
confusion, CYP2D6 or history of
arrhythmias, CYP3A4 such as seizures,
urinary retention. carbamazepine, current eating
phenytoin or disorder or
rifampin may severe hepatic
decrease effect. impairment.
Inhibitors of Least
CYP2D6 or expensive of
CYP3A4 such as oral
clarithromycin, medications
erythromycin, officially
grapefruit juice, indicated for
fluoxetine or smoking
paroxetine may cessation.
increase effect Caution in
and toxicity. patients with
cardiovascular
disease or
arrhythmias.
Consider
measuring
serum levels
to reach
therapeutic
dose (based
on efficacy
data for
depression).
Drug Class: Nicotine Receptor Partial Agonists

varenicline 0.5 mg daily po for 3 days Nausea (30%); may Combination Does not
Champix then BID for 4 days then be mitigated by with nicotine induce
0.5–1 mg BID po for 12 wk. taking on a full replacement cytochrome
$$$$$ Patient should quit smoking stomach, therapy may P450
1–2 wk after starting increasing water increase risk of enzymes;
varenicline. If patient is still intake or reducing adverse effects. excreted
smoking 4 wk after starting, dose. renally
reassess therapy; can be May cause unchanged.
continued for an additional insomnia; take Efficacy is
12 wk if patient has second daily dose dose related.
benefited. If 1 mg BID not at suppertime.
tolerated, can reduce to 0.5
mg BID. No tapering Neuropsychiatric
necessary when side effects such
discontinuing as
suicidal/homicidal
ideation have been
reported; monitor
closely for
changes in
mood/behaviour.
Close monitoring
by healthcare
practitioner for
those with pre-
existing psychiatric
disorders.
a
Cost of 30 day supply; includes drug cost only.
Dosage adjustment may be required in renal impairment.
Legend: $ < $25 $$ $25–50 $$$ $50–75 $$$$ $75–100 $$$$$ $100–125
Resource Tips
Canadian Lung Association. Available from: www.lung.ca. Note: World “No Tobacco Day” is May 31st each year.
Partner with your local Lung Association for more resources (such as pamphlets and handouts) to assist you with a
display or clinic day venue.
Health Canada. Quit4Life. Available from: www.quit4life.com.
Motivational Interviewing Network of Trainers (MINT). Available from: www.motivationalinterviewing.org.
Pharmacists for a Smoke-Free Canada. Available from psfcnetwork.com.
Physicians for a Smoke-Free Canada. Available from: www.smoke-free.ca.
Suggested Readings
Centre for Addiction and Mental Health. Canadian Action Network for the Advancement, Dissemination and
Adoption of Practice-informed Tobacco Treatment. Canadian smoking cessation clinical practice guideline. Toronto:
CAN-ADAPTT; 2011. Available from:
www.nicotinedependenceclinic.com/English/CANADAPTT/Guideline/Introduction.aspx.
The Lung Association. Making quit happen: Canada's challenges to smoking cessation. 2009. Available from:
www.lung.ca/news/advocacy-tools/our-publications.
Mallin R. Smoking cessation: integration of behavioral and drug therapies. Am Fam Phys 2002;65:1107-14.
Marcano Belisario JS, Bruggeling MN, Gunn LH et al. Interventions for recruiting smokers into cessation
programmes. Cochrane Database Syst Rev 2012;12:CD009187.
Smoking Cessation Products: Smoking Cessation Products
Product Manufacturer Dosage Form Active Ingredients

Butt It Out Paradise Promotions capsule lobelia 130 mg
Cravv Zpharm capsule cytisine 1.5 mg
Habitrol Step 1 Novartis Consumer Health patch, extended- nicotine 21 mg

release

release

release
Nic-Hit Gum 2 mg Euro-Pharm gum nicotine polacrilex 2

mg
Nic-Hit Gum 4 mg Euro-Pharm gum nicotine polacrilex 4

mg
Nic-Hit Mini-Lozenge 1 Euro-Pharm lozenge nicotine polacrilex 1

mg mg

mg mg

mg mg

mg mg
Nic-Hit Spray 1 mg Euro-Pharm oral spray nicotine 1 mg
Nic-Hit Spray 2 mg Euro-Pharm oral spray nicotine 2 mg
Nicoderm Step 1 McNeil Consumer patch, extended- nicotine 21 mg

Healthcare release

Healthcare release

Healthcare release
Nicorette Gum 2 mg McNeil Consumer gum nicotine polacrilex 2

Healthcare mg
Nicorette Gum 4 mg McNeil Consumer gum nicotine polacrilex 4
Healthcare mg
Nicorette Inhaler McNeil Consumer inhaler with nicotine 10 mg

Healthcare cartridges
Nicorette Lozenge 2 mg McNeil Consumer lozenge nicotine polacrilex 2

Healthcare mg
Nicorette Lozenge 4 mg McNeil Consumer lozenge nicotine polacrilex 4

Healthcare mg
Nicorette QuickMist McNeil Consumer oral spray nicotine 1 mg

Healthcare
Nicotine Gum 2 mg various gum nicotine 2 mg
Nicotine Gum 4 mg various gum nicotine 4 mg
Nicotine Patch 7 mg various patch, extended- nicotine 7 mg

release

release

release
Thrive Gum 2 mg Novartis Consumer Health gum nicotine polacrilex 2

mg
Thrive Gum 4 mg Novartis Consumer Health gum nicotine polacrilex 4

mg
Thrive Lozenge 1 mg Novartis Consumer Health lozenge nicotine bitartrate

dihydrate 1 mg
Thrive Lozenge 2 mg Novartis Consumer Health lozenge nicotine bitartrate

dihydrate 2 mg
patients. Once printed there is no quarantee the information is up-to-date. [Printed on: 05-11-2018 12:22 PM]
RxTx, Compendium of Products for Minor Ailments © Canadian Pharmacists Association, 2018. All rights reserved
Fever Non Pharm:
1. Dress in layers
2. drink plenty of fluids
Fever 3. Use of Tepid water cloth on forehead
4. Maintenance of room temp b/n 20-21
Yvonne M. Shevchuk, BSP, PharmD, FCSHP
Date of Revision: March 2016
5. Avoid any strenuous exercise
Introduction
Fever is a regulated elevation in core body temperature that is generally considered to be caused by infection; however,
noninfectious causes include inflammatory diseases, neoplasms and immunologically mediated conditions such as some drug
fevers.1,2 The definition of fever varies; anything above the normal range for body temperature can be defined as fever.1,2 Fever
in children is most often defined as rectal temperature >38°C if the child is appropriately dressed and resting.3 In adults and
children, an individual's body temperature varies with the time of day (normal circadian variation); it is lowest at approximately 6
a.m. and highest between 4 and 6 p.m.1 The mean amplitude of variability is 0.5°C. Oral temperatures >37.2°C in early morning
or ≥37.8°C any time during the day may also be used to define fever.1,4 Outside the neonatal period, children generally have a
higher temperature than adults; however, this is poorly documented.5,6 Basal core temperatures decrease toward the adult
range by 1 year of age and continue to decline until puberty. The degree of response to antipyretics does not distinguish serious
bacterial infections from viral infections.3
Mild elevations in body temperature occur with exercise, ovulation, pregnancy, excessive clothing (overbundling of infants),
ingestion of hot foods or liquids and chewing gum or tobacco.1
Rectal temperatures are approximately 0.6°C higher and axillary temperatures approximately 0.5–1°C lower than oral
temperatures.3 A high fever is usually defined as a temperature >40.5°C. Fever is a regulated physiologic response and
temperatures >41°C are rare.2,7
Pathophysiology
The thermoregulatory centre in the anterior hypothalamus normally controls core temperature within a narrow range by
balancing heat production by muscle and liver tissues with heat dissipation from skin and lungs. With fever, the
thermoregulatory set-point is elevated.1,2 Endothelial cells of the organum vasculosum laminae terminalis, a network of
enlarged capillaries surrounding the hypothalamus, release arachidonic acid metabolites when exposed to pyrogens in the
circulation. Prostaglandin E2, released by the hypothalamus, is thought to be the major substance producing an elevation of the
thermoregulatory set-point. Initially, with an elevated set-point, there is vasoconstriction of peripheral blood vessels to conserve
heat, shivering to increase heat production, and behavioural changes such as seeking warmer environments and clothing. When
the set-point is reduced through administration of antipyretics or disappearance of pyrogens, the reverse occurs—vasodilation
and sweating to dissipate heat, as well as behavioural changes such as removal of clothing.2
Sources of pyrogens (substances that cause fever) are both exogenous and endogenous.1,2 The most common exogenous
sources are microorganisms and their products or toxins (e.g., lipopolysaccharide endotoxin of gram-negative bacteria).
Exogenous pyrogens induce formation and release of endogenous pyrogens. Endogenous pyrogens or pyrogenic cytokines are
polypeptides produced by host cell macrophages, monocytes and other cells. The most common are interleukin 1α and 1β (IL
1α and 1β), tumor necrosis factor alpha (TNF α), IL-6, ciliary neurotropic factor (CNF) and interferon gamma (IFN γ).
Goals of Therapy
Provide patient comfort
Reduce parental anxiety
Reduce metabolic demand caused by fever in patients with cardiovascular or pulmonary disease
Prevent or alleviate fever-associated mental dysfunction in the elderly (common practice but evidence is unclear)
Patient Assessment
Figure 1 presents an algorithm for the assessment of patients with fever.
Fever is a symptom or sign of illness, not a disease, and the reason for fever should be determined.3 Most commonly it is due
to infection, often viral. Children <6 months of age with a fever should be assessed by an appropriate healthcare practitioner.8
Fever persisting longer than 3 days in those >6 months, recurrent fever, or high fever (>40.5°C) should be evaluated by an
appropriate healthcare practitioner.
Once fever is established, the body initiates processes to permit homeostasis. Peripheral vasodilation causes the skin to feel
hot. Sweating may occur. Malaise and fatigue may be seen at higher temperatures. Headache, backache, myalgia, arthralgia,
somnolence, chills and rigors may also be associated with fever.
Drug-induced fever is a symptom of hypersensitivity but can occur with other symptoms such as myalgia, chills and headache.
Table 1 lists several medications associated with drug-induced fever.9,10,11
Fever differs from hyperthermia, which is an increase in core temperature without an increase in hypothalamic set-point. If
hyperthermia is suspected, refer the patient to an appropriate healthcare practitioner; antipyretics are not useful (see Heat-
Related Disorders).
9,10,11
Table 1: Selected Drugs Associated with Fever
allopurinol digoxin methyldopa
amphotericin B diltiazem metoclopramide
antacids doxepin mycophenolate
antibacterials/antibiotics (e.g., epinephrine nifedipine
cephalosporins, penicillins, folic acid NSAID (e.g., ibuprofen,
SMX/TMP) naproxen)
furosemide
anticholinergics oral contraceptives
griseofulvin
antihistamines phenytoin
heparin
antineoplastics (e.g., cisplatin, procainamide
hydroxyurea) hydralazine
hydrochlorothiazide propylthiouracil
antipsychotics
H2-receptor antagonists (e.g., cimetidine) quinidine
atropine
quinine
azathioprine insulin
rifampin
barbiturates interferon
salicylates
carbamazepine iodides
sulfasalazine
clofibrate iron dextran
tacrolimus
corticosteroids isoniazid
triamterene
cyclosporine MAOI
vitamins
Abbreviations: MAOI = monoamine oxidase inhibitor; NSAID = nonsteroidal anti-inflammatory drug; SMX/TMP
= sulfamethoxazole/trimethoprim
Measurement of Body Temperature
For comparative features of nonprescription products, consult the Compendium of Products for Minor Ailments—Home
Testing Products: Thermometers.
There are a number of methods of measuring temperature in an ambulatory setting—oral, rectal, axillary, tympanic
membrane, temporal artery and transcutaneous (see Table 2).8 Oral, rectal and axillary temperatures may be taken with an
electronic thermometer with a digital display (digital probe). Standard mercury-in-glass thermometers are no longer
recommended due to potential toxicity if they break,8 environmental concerns and problems with proper use including long
equilibration times, difficulty in reading them properly and inability to reset the thermometer. Electronic thermometers are
safer and easier to use because they are faster and easier to read and avoid the environmental concerns of mercury.
Generally, equilibration times require 30–60 seconds, while up to 10 minutes are required for standard glass thermometers.
It is difficult to make clear recommendations on the ideal method of measuring temperature since many of the studies are
small or have methodologic flaws. In addition, most studies are conducted in emergency departments or inpatient settings.
Few studies are conducted in patients' homes which may be the most relevant to self-care. Recommendations from Caring
for Kids remain the most reliable source of information. See Suggested Readings.
Normal, route-specific temperature ranges and preferred routes based on age are listed in Table 3 and Table 4.
Table 2: Methods of Measuring Body Temperature

Method Description Instructions For Use
Method Description Instruction for Use
Rectal8 Considered the most accurate and the Children:
standard against which other routes of Place the infant on his back with knees
temperature measurement are bent or lay infant or young child face
compared.1,7,12 down across parent's lap or in fetal
This route is preferred for newborns, for position on flat surface.
children less than 4–5 y when an axillary Lubricate anus and thermometer with
temperature is not sufficient, and when the petroleum jelly (pea-size quantity).
oral route is not suitable due to mouth With one hand gently insert
breathing. May be less acceptable to toddlers. thermometer 2–3 cm into rectum.
It is contraindicated in premature infants,1 the Hold buttocks closed against
immunocompromised7 and in the presence of thermometer with other hand.
rectal anomalies, recent anorectal surgery or Leave thermometer in place until it
severe hemorrhoids. A rare complication is beeps and temperature is displayed.
perforation of the rectum. This route may also
transmit infections.7
Oral8 This route can be used in children over 5 y and Place thermometer on either side of
adults;7 younger children may bite the mouth (between gum and cheek) or
thermometer or have difficulty keeping it in the under the tongue.
closed mouth. This may also be a problem for Hold in place with lips or fingers (not the
individuals who have difficulty understanding teeth).
instructions, e.g., the mentally impaired or Breathe through nose with mouth
elderly with dementia.1 closed.
Avoid the oral route when nasal breathing is Leave thermometer in place until it
difficult (e.g., due to viral upper respiratory beeps and temperature is displayed.
tract infection); mouth breathing will cause
spuriously low temperatures. Beverages, either
hot or cold, and smoking should be avoided
for at least 10 min prior to taking an oral
temperature.1,7
Axilla8 Axillary (armpit) temperatures have many Place thermometer in apex of axilla.
disadvantages.7 They take a longer time to Hold elbow against chest to stabilize the
measure and are affected by a number of thermometer.
factors including hypotension, cutaneous Leave thermometer in place until it
vasodilation and prior cooling of the patient. beeps and temperature is displayed.
Axillary temperature may be a poor alternative
to rectal temperatures in children aged 3
months to 6 y.13,14
Although axillary temperatures are generally
considered to be approximately 0.5°C lower
than oral temperatures, reliable data are not
available to correlate axillary with oral or rectal
temperatures. The advantages of axillary
temperatures are that this route is very
accessible, safe and less frightening to
children than rectal temperatures.7
The reading should be confirmed via another
route if the axillary temperature is >37.2°C.
Ear15 A tympanic thermometer (TT) measures Follow specific manufacturers'
infrared emissions from the tympanic directions as they may vary.
membrane.1,16 Apply a clean probe tip.
The tympanic membrane and the Gently tug on ear, pulling it back. This
hypothalamus share the same blood supply. helps to straighten the ear canal so an
TT may better reflect core temperature accurate reading can be obtained.
measurements.1 The temperature is then Gently insert the thermometer into the
converted by the thermometer to reflect oral or ear until the ear canal is fully sealed off.
rectal temperatures, which may lead to some Squeeze and hold down the button for 1
inaccuracy in the temperature reading. Proper second (or until the device beeps).
placement in the ear canal is important.6
Remove from the ear and read
Improper placement can result in a lower
temperature.
reading that reflects the outer ear canal wall
temperature.6 There may be a poor correlation
between typmanic and rectal temperatures
and TT may not be sensitive enough to screen
for fever in pediatric patients.17,18,19
Performance was good in adults, including the
elderly.20 The Canadian Paediatric Society
does not recommend TT for children <2 y.8
Advantages of TT include simplicity, speed
and patient acceptance.7 Less than 2 seconds
is needed to obtain a reading. Other
advantages include lack of external influences
such as hot beverage ingestion, and no
mucous membrane contact, therefore minimal
risk of disease transmission.7 Acute otitis
media and nonobstructive cerumen do not
appear to affect the accuracy of TT.16
A disadvantage is high cost.
Transcutaneous “Fever strips” contain encapsulated Based on poor performance in studies, use
thermophototropic esters of cholesterol cannot be recommended for children or
(called liquid crystals) that change colour in adults.
response to temperature changes. They are
easier to read and require less time than a
standard thermometer, but are less reliable
because skin temperature is not a reliable
indicator of core temperature.1,6,7,8,21,22
When studied in emergency departments,
fever strips were poor predictors of fever.22,23
Accuracy is affected by ambient temperature
such as cold hands holding the strip or nearby
heat sources such as a lamp. A truly febrile
child may register as afebrile, possibly
delaying medical attention.
Temporal artery Like the TT, the temporal artery (TA) Follow specific manufacturers'
(forehead)24 thermometer uses infrared technology to directions as they may vary.
measure the temperature using a heat balance Remove dirt, hair or sweat from
method.25 forehead area.
Infrared sensors compute a temporal artery Turn unit on.
temperature by rapid, repeated measures to Press button a second time.
synthesize skin surface and ambient
temperature. It is similar to the TT in that it is Place thermometer probe gently and
very quick (3 seconds) and avoids any flush onto the area approximately 1.25
cm above the centre of the eyebrow.
mucous membrane contact.25
Sweep the skin from above eyebrow to
It may be prone to less error than the TT26 but temple until you hear a beep.
is not considered as accurate as rectal Read the temperature display.
temperatures in children.26,27,28
A clinically significant difference of 0.5°C was
found between the oral and TA route in 49% of
patients.29
A geriatric study (age >75) determined that
diagnostic accuracy for infection was lower
for temporal artery thermometry compared
with rectal or tympanic measurement.30
Table 3: Normal Pediatric Temperature Ranges Associated with Measurement Technique

Measurement Technique Normal Temperature Range
Rectum 36.6–38°C (97.9–100.4°F)
Mouth 35.5–37.5°C (95.9–99.5°F)
Armpit 34.7–37.3°C (94.5–99.1°F)
Ear 35.8–38°C (96.4–100.4°F)
Source: Canadian Paediatric Society, 2015. Fever and temperature taking. For more information, visit www.caringforkids.cps.ca.
Table 4: Recommendations for Temperature Measuring Techniques

Age Recommended Technique
Birth to 2 y First choice: Rectum (for an exact reading)
Second choice: Armpit (to check for fever)
Not recommended: Tympanic membrane thermometers
Between 2 and 5 y First choice: Rectum
Second choice: Ear, armpit
Older than 5 y First choice: Mouth
Second choice: Ear, armpit
Source: Canadian Paediatric Society, 2015. Fever and temperature taking. For more information, visit www.caringforkids.cps.ca.
Nonpharmacologic interventions include removal of excess clothing and bedding, increased fluid intake to replace increased
insensible water loss during fever, maintenance of ambient temperatures around 20–21°C, and avoidance of physical exertion.8
Sponging increases evaporation and promotes heat loss. Tepid water sponging may help reduce body temperature; however, it
does not reset the thermoregulatory set-point.31 Therefore, the body actually works harder to maintain the elevated temperature
by shivering, which results in increased oxygen consumption. Sponging often causes significant patient discomfort.32 Studies
show no additional benefit from sponging after antipyretic administration.33,34,35 If used, administer antipyretics 30 minutes
before sponging to reduce thermoregulatory set-point.
If tepid sponging is performed, use water only. Though rarely, isopropyl alcohol sponging has resulted in hypoglycemia,
intoxication and coma as a result of absorption through the skin or inhalation of fumes, and is not recommended.32,36
For additional information, consult the Compendium of Therapeutic Choices: Fever in Children.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Analgesic
Products: Internal Analgesics and Antipyretics.
There are many arguments against treating a fever:1,2,37,38,39
Fever is an important defence mechanism; it enhances the immune response.

Use of antipyretics may impair the use of temperature as an important clinical tool for monitoring the progress of an
infection or response to antibiotics.
Fever is usually self-limiting, and though sometimes distressing, the consequences of fever (mild dehydration, discomfort,
febrile delirium or febrile seizures) are usually not harmful.
Therefore, the decision to use antipyretics must be individualized. The goal should be reduction of fever rather than “normal”
body temperature. Assessment of the patient should not depend solely on the elevation of temperature (see Figure 1).
Acetaminophen, ASA, ibuprofen and naproxen sodium are all currently indicated to reduce fever. These drugs reduce body
temperature in febrile patients by decreasing prostaglandin synthesis in the brain and reducing the thermoregulatory set-
point.1,37 They do not lower normal body temperature. Short-term treatment with these drugs is associated with few side
effects. Intermittent administration of antipyretics may result in drug-induced fluctuations in temperature and concomitant
shivering which may make the individual feel worse. Use at regular intervals may reduce patient discomfort and the risk of
increased metabolic demand caused by shivering.
Acetaminophen is a relatively safe and effective antipyretic with few contraindications, and can be used in any age group.40,41
Many years of clinical experience is also an advantage. Using a loading dose of acetaminophen 30 mg/kg in children 4 months
to 9 years of age resulted in a more rapid and sustained response and a greater reduction in temperature compared with 15
mg/kg.42 Although used in some emergency departments, the safety of this practice has not been evaluated and the dose is an
initial dose only; subsequent doses should be 10–15 mg/kg. Do not recommend a loading dose to parents. Acetaminophen
overdose resulting in hepatotoxicity remains a concern. In response to this concern, Health Canada has developed labelling
standards which includes warnings regarding hepatotoxicity and maximum package sizes for pediatric products and is
reviewing the option of decreasing the maximum recommended daily dose.43,44 It is the preferred agent in those with renal
dysfunction or risk factors for GI bleeding.
Standard dosing is provided in Table 5.
Ibuprofen is an alternative to acetaminophen when there are no contraindications to its use. There is less experience with
ibuprofen and it is more expensive, but with short-term use in children there appears to be no difference in adverse event rates
compared with acetaminophen.45,46,47,48 However, renal failure in children has been reported, particularly when the child is
dehydrated; therefore, avoid in children with diarrhea and vomiting.8,49 In one study, time without fever in the first 4 hours after
administration was greater and time to fever clearance was shorter with ibuprofen compared with acetaminophen.50 A meta-
analysis showed that ibuprofen (5–10 mg/kg) as compared with acetaminophen (10–15 mg/kg) was a better antipyretic
producing greater temperature reductions at 2, 4 and 6 hours after dosing.51 Ibuprofen may also have a longer duration of
action51 than acetaminophen and is less toxic in overdose.52,53
ASA should be avoided in children younger than 18 years who have a viral illness because of its association with Reye's
syndrome in influenza and varicella. Reye's syndrome consists of acute encephalopathy with cerebral edema, fatty infiltration of
the liver and metabolic derangements such as hypoglycemia. It occurs in otherwise healthy children. Since the cause of fever is
unknown initially in many circumstances, avoid ASA in children.54,55,56
Naproxen sodium is the most recent nonprescription NSAID available for fever. It has a longer half-life with a corresponding
less frequent administration schedule. There are no data on the use of naproxen sodium for treatment of fever in children.
Alternating Antipyretics
In the past, alternating acetaminophen with ASA was recommended for management of fever unresponsive to a single
agent. This practice has been abandoned due to an association with Reye's syndrome. Recommendations to alternate
acetaminophen with ibuprofen have emerged.57,58 Alternating or combining acetaminophen and ibuprofen may result in a
greater period of time without fever but the clinical significance is uncertain.50,59,60,61 The goal of treating a febrile child
should be to reduce discomfort rather than to normalize the temperature. It is important to note that no difference was
found in patient discomfort in the only 2 trials to assess it.50,60,62 Safety and superior effectiveness of the combination has
not been proven.63,64 In fact, the practice of combining or alternating antipyretics may not be as safe as previously thought.
A review of FDA’s AERS database concluded that concomitant use of ibuprofen and acetaminophen in children may be
associated with an increased risk of acute kidney injury.65
Parents and caregivers often find the recommendation to combine antipyretics confusing and it may result in increased
dosing errors.66,67 In addition, it may serve to reinforce fever phobia. Both caregivers and healthcare practitioners should be
educated to avoid combination therapy with acetaminophen and ibuprofen.68
Table 5 outlines dosing, side effects, contraindications and precautions for ASA, acetaminophen, ibuprofen and naproxen
sodium.
Fever in Specific Patient Groups
Children
Young children have an immature thermoregulatory system. In the first 2 months of life, infants may have minimal or no
fever during an infectious illness. Since neonates and infants are less able to mount a febrile response, a fever is more
likely to indicate a major illness. Evaluation based on symptoms and physical examination is more challenging, and it is
more difficult to accurately predict serious bacterial infection than in older children. After 3 months of age, the degree of
fever more closely approximates that seen in older children.69
Fever is common in children and is frequently due to bacterial or viral infection. Because children have had less exposure
to infectious agents than adults, they are more susceptible upon initial contact. Reactions to vaccinations may also be a
cause of fever. Compared with adults, children are more sensitive to ambient temperature (due to a greater body surface
area for heat exchange) and at higher risk of dehydration.69
In children ages 3 months to 5 years, seizures occur with 2–5% of febrile episodes.70 Although simple febrile seizures
are rarely associated with neurologic damage or permanent seizure disorders, they concern and frighten parents. For
this reason, antipyretics are often recommended for children in this age group, particularly those with previous febrile
seizures or neurologic problems. Using antipyretics at the first sign of fever does not prevent recurrent febrile seizures
even though this practice is frequently recommended.70,71,72,73
Patients with Cardiovascular or Pulmonary Disorders
Increased metabolic demands which occur during the chill phase (increased metabolic rate, norepinephrine-mediated
peripheral vasoconstriction, increased arterial blood pressure) may aggravate comorbid disease states in patients with
heart failure or coronary, pulmonary or cerebral insufficiency. Fever may result in deterioration in cognitive function and
delirium.1
The Elderly
Older individuals exhibit less intense fevers in response to infection compared with younger individuals.74 They also
become hypothermic more often when infected and suffer greater morbidity and mortality from infections.74 Fever in
individuals older than 60 years is less likely to be a benign febrile illness than in younger individuals;75 therefore, careful
assessment of fever in the elderly is important. The elderly are more likely to experience the cardiovascular and
pulmonary conditions described above. Acetaminophen is safer in older individuals with risk factors predisposing to GI
and renal toxicity of NSAID.
Pregnancy
Studies in humans suggest that exposure to fever and other heat sources during the first trimester of pregnancy is
associated with increased risk of neural tube defects and multiple congenital abnormalities.76,77 Although one study
indicated a possible benefit of antipyretic therapy,78 others have not79 and a recent meta-analysis suggests additional
research is required.80
Acetaminophen crosses the placenta and is relatively safe for short-term use in pregnancy when therapeutic doses are
used.
Use of ASA and NSAID can result in a number of problems during pregnancy, including cardiac issues. They should be
avoided in the first and third trimesters of pregnancy. Low-dose ASA is considered compatible with pregnancy.81 Since
these drugs inhibit prostaglandin synthesis, they may interfere with labour and cause premature closure of the ductus
arteriosus resulting in persistent pulmonary hypertension in the infant. Platelet aggregation is inhibited in the newborn if
ASA is ingested by the mother within 7 days of delivery and salicylates displace bilirubin from protein binding sites.
Increased bleeding has been reported in both mothers and infants if ASA is ingested close to the time of delivery.52 See
Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions.
Both acetaminophen and ibuprofen are considered safe to take while breastfeeding.81
Fever Phobia
The term “fever phobia” describes unrealistic concerns and misconceptions of parents and healthcare practitioners
regarding fever in children.82,83,84,85,86,87,88 Healthcare practitioners should undertake educational interventions to ensure
appropriate management of fever and rational use of antipyretics.
Optimizing Dosing and Administration
Review the following points with all parents when recommending an antipyretic preparation:
Ensure parents/caregivers understand that fever is rarely harmful and does not have to be treated
Explain that comfort is the goal and not achievement of an arbitrary “normal” temperature
Assist parents in calculating the correct mg/kg dose of the drug and ensure they know the maximum number of doses
that can be administered in a 24-hour period
In a study of 100 caregivers given a mock dosing scenario that required caregivers to determine and measure a
correct dose of acetaminophen for their child, only 40% stated an appropriate dose for their child89
Of 118 children given an antipyretic at home and subsequently brought to the emergency department, only 47%
had been given a proper dose.90 Underdosing may be a cause of unnecessary emergency department visits.91
This also leads to added stress for both the parent and sick child92
Ensure the parent has and will use an appropriate measuring device
In the mock dosing study reported above, only 67% of caregivers accurately measured the amount they intended
to give. Forty-three percent measured out a correct amount of acetaminophen; however, 30% of these did so by
accident by inaccurately measuring an improper dose89
Consider demonstrating the correct use of the dosing device. Ask the caregiver to repeat instructions back to you.
It may be helpful to mark the dosing device with the correct dose93
Ask what form of product they have at home and calculate the appropriate volume of liquid or number of tablets for
the child. Explain the differences in concentration between drops and syrup and that tablets come in different
strengths for children93
Multiple miscalculated overdoses of acetaminophen given by parents represent an important cause of
acetaminophen toxicity94,95,96
Use of incorrect measuring devices, differences in medication concentrations (e.g., pediatric drops vs.
suspensions), use of adult formulations for pediatric patients and unrecognized acetaminophen content in
multiple-ingredient cough and cold products contribute to this problem95
Ask about other preparations, particularly cough and cold products, they may be coadministering and ensure they are
aware of the antipyretic content of these products. The coadministration of these products should be carefully
monitored to ensure the cumulative dose is within the recommended range.
Recommendations for frequent monitoring of temperature likely contribute to parental concern and fever phobia. The
temperature should be taken if the patient feels warm or looks ill, to determine the initial temperature. Subsequently,
temperatures need not be taken more than 2–4 times daily unless the patient has recently received chemotherapy. If the fever
persists for 24 hours without an apparent cause, or for more than 3 days, medical attention should be sought. The degree of
illness and not the temperature should guide therapy and referral.
Monitor:
All patients given antipyretics for development of rash or other allergic reactions
Patients with pre-existing comorbid illness for edema and decreased urine output
For other common side effects, such as GI intolerance and tinnitus (see Table 5)
To ensure appropriate doses, products and measuring devices are being used, and the patient is not receiving excessive
amounts of antipyretics through use of cough and cold or analgesic products
To ensure the patient is not receiving interacting medications (see Table 5). Recommend avoiding alcohol.
Fever Non Pharm:

Algorithms
1. Dress in layers
1,3,6,8 2. drink plenty of fluids
Figure 1: Assessment of Patients with Fever
3. Use of Tepid water cloth on forehead
4. Maintenance of room temp b/n 20-21
5. Avoid any strenuous exercise
6. Comfort Pt./child anyway possible
children
tugging ear
Might be malaria
Drug Table
Table 5: Drug Therapy for Fever
Class Drug Dosage Adverse Effects Drug Interactions Comments Costa
Class Drug Dosage ADR Drug Intxn Comments Cost
NSAID ibuprofen Adults: 200– Uncommon Alcohol and Renal $
Advil, Advil 400 mg Q4-6H with infrequent corticosteroids: dysfunction: No
Children/Pediatric, po PRN use and Increased risk of adjustment
Advil Junior (maximum for recommended GI required;
Strength, Advil self-care 1200 dose. pain/ulceration. however,
Liqui-Gels, Motrin, mg/day; GI intolerance Antagonism of should be
Motrin supervised and bleeding, hypotensive avoided in renal
(Children's), maximum allergic effects of ACEI, dysfunction
Motrin IB, Motrin 2400 mg/day) reactions, diuretics, beta- due to effects
Liquid Gels, Children >6 tinnitus, visual blockers. of
generics months: 5–10 disturbances, Anticoagulants: prostaglandin
mg/kg Q6–8H nephropathy. increased risk of inhibition on
po PRN for Sodium and bleeding. renal function.
water retention. Increased risk of Limited data
symptom
management; Dehydration bleeding with exist for the
maximum 40 enhances risk SSRIs. use of
mg/kg/day of renal toxicity. Increased levels ibuprofen in
Platelet of cyclosporine children <2
Children <6 dysfunction can and risk of months.
months: 5 result in nephrotoxicity. Do not give if
mg/kg Q8H increased Increased levels dehydration is
Do not exceed bleeding risk. of lithium, present; ensure
adult dose adequate
methotrexate.b
Reduction of intake of fluids.
antiplatelet NSAIDs have
been
effects of ASA.97
associated with
an increased
risk of severe
skin and soft
tissue
infections in
children with
chicken pox
and to a lesser
extent adults
with shingles.98
Some
nonprescription
products
contain
ibuprofen in
combination
with other
drugs. Advise
patients and
caregivers to
check labels
carefully to
avoid
inadvertent
administration
of excessive
doses.
NSAID naproxen sodium Adults: 220 Uncommon Alcohol and Renal $
Aleve, Anaprox, mg Q8–12H with infrequent corticosteroids: dysfunction: No
Maxidol, generics po PRN; use and Increased risk of adjustment
maximum 440 recommended GI required;
mg/day dose. pain/ulceration. however,
Children: Not GI intolerance Antagonism of should be
recommended and bleeding, hypotensive avoided in renal
under 12 y allergic effects of ACEI, dysfunction
reactions, diuretics, beta- due to effects
tinnitus, visual blockers. of
disturbances, Anticoagulants: prostaglandin
nephropathy. increased risk of inhibition on
Sodium and bleeding. renal function.
water retention. Increased risk of Limited data
Dehydration bleeding with exist for the
enhances risk SSRIs. use of
of renal toxicity. Increased levels ibuprofen in
Platelet of cyclosporine children <2
dysfunction can and risk of months.
result in nephrotoxicity. Do not give if
increased Increased levels dehydration is
bleeding risk. of lithium, present; ensure
methotrexate.,b adequate
Reduction of intake of fluids.
antiplatelet NSAIDs have
been
effects of ASA.97
associated with
an increased
risk of severe
skin and soft
tissue
infections in
children with
chicken pox
and to a lesser
extent adults
with shingles.98
Some
nonprescription
products
contain
ibuprofen in
combination
with other
drugs. Advise
patients and
caregivers to
check labels
carefully to
avoid
inadvertent
administration
of excessive
doses.
Para- acetaminophen Adults: 325– Uncommon Alcohol: Use with $
aminophenol Atasol 650 mg Q4-6H with infrequent Increased risk of caution in
Derivatives Preparations, po/pr PRN use and hepatotoxicity. patients with
Tempra, Tylenol, (maximum recommended Isoniazid: liver
generics 4000 mg/day) dose. Increased risk of dysfunction or
Children: 10– Hypersensitivity, hepatotoxicity. active liver
15 agranulocytosis disease.
Enzyme inducers
mg/kg/dose and anemia (e.g., barbiturates, Rectal
Q4–6H po as (rare). carbamazepine, administration
needed for Chronic use and isoniazid, results in
symptom overdose phenytoin) erratic
management; associated with decrease absorption and
maximum 75 hepatotoxicity, acetaminophen should be used
mg/kg/day; nephropathy. levels. under
do not exceed healthcare
adult dose Potential for Acetaminophen practitioner
toxicity has been supervision.
enhanced if reported to
concurrent increase INR in Available as
dehydration, warfarin-treated oral drops,
prolonged tablets,
patients.99 Check chewable
fasting, INR if
diabetes tablets,
acetaminophen suppositories
mellitus, ≥2 g/day is used
obesity, and
for ≥3 suspension.
concomitant consecutive days.
viral infection or Adjust warfarin Acetaminophen
family history of dosage as may be
hepatotoxic required. associated with
reaction. exacerbation of
wheezing in
febrile
children.100
Many
nonprescription
products
contain
acetaminophen
in combination
with other
drugs. Advise
parents and
caregivers to
check labels
carefully to
avoid
inadvertent
administration
of excessive
doses.
Salicylates ASA Adults: 325– GI upset. Alcohol and Avoid if ClCr $
Aspirin, Coated 650 mg Q4H Avoid in corticosteroids: <10 mL/min.
Aspirin, generics po; maximum patients with Increased risk of Enteric-coated
4000 mg/day renal failure, GI products will
Children: peptic ulcer pain/ulceration. have delayed
Avoid use with disease, heart Anticoagulants: onset of action.
fever under 18 failure and ASA- Increased risk of
y sensitive bleeding.
asthma. Increased levels
of methotrexate.b
ASA may
decrease
therapeutic effect
of uricosuric
agents
(probenecid,
sulfinpyrazone)
Increased risk of
GI bleeding with
SSRIs.
Antihypertensives
(diuretics, beta-
blockers, ACEI,
alpha-blockers):
possible
reduction in
antihypertensive
effect; may
require additional
antihypertensive
therapy.
a
Cost per day; includes drug cost only.
b More likely to occur with antineoplastic doses of methotrexate.
Abbreviations: ACEI = angiotensin converting enzyme inhibitor; GI = gastrointestinal; NSAID = nonsteroidal anti-inflammatory drug
Legend: $ <$1
Suggested Readings
American Academy of Pediatrics. Committee on Drugs. Acetaminophen toxicity in children. Pediatrics 2001;108:1020-4.
Aronoff DM, Neilson EG. Antipyretics: mechanisms of action and clinical use in fever suppression. Am J Med 2001;111:304-15.
Canadian Paediatric Society. Caring for Kids. Fever and temperature taking. Available from:
www.caringforkids.cps.ca/handouts/fever_and_temperature_taking.
Crocetti M, Moghbeli N, Serwint J. Fever phobia revisited: have parental misconceptions about fever changed in 20 years?
Pediatrics 2001;107:1241-6.
Fields E, Chard J, Murphy MS et al. Assessment and initial management of feverish illness in children younger than 5 years:
summary of updated NICE guidance. BMJ 2013;346:f2866.
Plaisance KI. Toxicities of drugs used in the management of fever. Clin Infect Dis 2000;31:S219-23.
Section on Clinical Pharmacology and Therapeutics; Committee on Drugs, Sullivan JE et al. Fever and antipyretic use in
children. Pediatrics 2011;127:580-7.
Simon HK, Weinkle DA. Over-the-counter medications. Do parents give what they intend to give? Arch Pediatr Adolesc Med
1997;151:654-6.
Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures. Febrile seizures: clinical
practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics 2008;121:1281-6.
References
Headache
Irene Worthington, BScPhm

Date of Revision: August 2017
Introduction
This chapter focuses on 3 of the most common headache disorders: tension-type headache and migraine (primary headache disorders), and medication-overuse headache
(secondary headache disorder). A full list of headache disorders and their classification is published by the International Headache Society (IHS).1
Pathophysiology
Tension-type Headache
Tension-type headache (TTH) is the most common type of headache. It is diagnosed mainly by the presence of a headache lasting 30 minutes to 7 days that has at least
2 of the following criteria: bilateral location, a pressing/tightening quality, mild or moderate intensity, not aggravated by routine physical activity, and an absence of
features found in other types of headache (e.g., migraine). Although mental stress and tension are frequently thought to precipitate TTH, the exact pathophysiology is
unknown. Both peripheral (myofascial tissues) and central mechanisms are thought to contribute to pain in TTH.2 Since there are significant overlapping features, some
headache experts believe that TTH is a variant of migraine; however, epidemiologic studies have concluded that migraine and TTH are different disorders that coexist in
many patients.1 TTH can be episodic or chronic (headache on ≥15 days per month). The lifetime prevalence of TTH is around 80%, and about 3% for chronic TTH. TTH
appears to be more prevalent in women, and declines with age in both women and men.2
Migraine
Migraine is a common, underdiagnosed, often incapacitating neurovascular disorder characterized by recurrent attacks of headache pain (generally moderate to severe),
autonomic nervous system dysfunction, and neurologic symptoms in some patients.3 The IHS describes the diagnostic features of migraine subtypes.1 The 2 most
common are migraine with aura and migraine without aura. The specific cause of migraine is unknown but genetic factors are likely involved. It has been proposed that
specific triggers can provoke CNS dysfunction in susceptible individuals, leading to dilation of intracranial and extracerebral blood vessels and activation of the
trigeminal sensory nerves (resulting in release of vasoactive peptides such as calcitonin gene-related peptide), with subsequent relaying of pain signals to the brain.
Migraine attacks may be episodic or chronic (≥15 days per month). Approximately 15% of patients experience migraine attacks preceded or accompanied by transient
focal neurologic symptoms (usually visual), referred to as an aura. Aura is thought to be caused by neuronal dysfunction, not ischemia or vasoconstriction as previously
believed. Aura can also occur without a subsequent headache. In North America and Western Europe, the 1-year prevalence of migraine is 11% overall: 15–18% among
women and 6% among men. Attacks may last from 4–72 hours.3,4 Status migrainosus is a debilitating migraine attack that lasts more than 72 hours.
Medication-overuse Headache
Medication-overuse headache (MOH) is an under-recognized condition that may occur in patients who suffer from migraines (primarily) or tension-type headaches.
Recognition and treatment of MOH may lead to long-term improvement in headache relief and quality of life for many patients. Frequent use of analgesics or other acute
migraine medications for ≥3 months can lead to MOH (headache present on ≥15 days per month) in patients with migraine/tension-type headaches. MOH can occur in
association with simple analgesics (e.g., acetaminophen, ASA) or, less commonly, with NSAIDs. It is more common with combination products containing barbiturates,
caffeine and/or opioids. Overuse of ergotamine or triptans and withdrawal from substances such as caffeine, opioids and estrogen have also been implicated.1,5
Goals of Therapy
Identify potentially serious causes of headache and refer patient for diagnosis/treatment. Patients with sudden, severe headache should go to an emergency room
Relieve pain and associated symptoms (e.g., nausea/vomiting) so that patient can return to normal functioning
Prevent recurrence of migraine headache
Prevent medication-overuse headache
Patient Assessment
The IHS has established criteria for the diagnosis of various headache disorders.1 There are no diagnostic tests for primary headache disorders (e.g., tension-type
headache, migraine, cluster headache). Diagnosis is based on symptoms, after ruling out any serious underlying disorders.6,7,8,9,10,11 Secondary headache disorders are
those associated with organic causes (e.g., trauma, meningitis, space-occupying lesion). Some medical procedures are associated with headache (e.g., lumbar puncture,
rhinoscopy).
Patients with occasional tension-type headache do not require further assessment unless the headaches become chronic (≥15 days/month). Patients with features of
migraine require assessment, diagnosis and appropriate treatment. Patients with any unusual headache require further assessment; if the headache is very severe, with a
sudden onset, refer immediately to an emergency room (see Red Flags for Serious Headache).
A stepwise approach to headache assessment and treatment is provided in Figure 1.
Common Signs and Symptoms
Table 1 outlines the clinical features of tension-type and migraine headache.
Table 1: Clinical Features of Tension-type Headache and Migraine

Clinical Feature Tension-type Headache Migraine
Quality of headache Pressing/tightening (nonpulsating) Throbbing/pulsating (at least part of the time)
Severity Mild to moderate Usually moderate to severe, although can be mild
Location Bilateral Usually unilateral (can be bilateral, especially in children)

Clinical Feature Tension-type Headache Migraine
Frequency Episodic (<15 days/month) or chronic (≥15 Episodic (<15 days/month) or chronic (≥15 days/month)
days/month)
Duration 30 min to 7 days 4–72 h
Aggravated by physical activity No Yes
Associated symptoms No nausea/vomiting (anorexia may occur) At least one of the following:
Photophobia or phonophobia but not both 1. nausea and/or vomiting
2. photophobia and phonophobia
May occur with or without aura (usually visual)
Differential Diagnosis
In addition to the primary headache disorders listed in Table 1, other possible etiologies of headache include:1,6,7,8,12
Primary headache types such as benign cough headache, benign exertional headache, cluster headache and other trigeminal autonomic cephalgias, hemicrania
continua, cold-stimulus headache, primary stabbing headache and new daily persistent headache
Infections such as meningitis and encephalitis
Temporal arteritis (an important cause of headache in those over 50 years of age; associated with systemic symptoms and elevated erythrocyte sedimentation rate;
if left untreated, often leads to permanent blindness)
Cerebral ischemia (stroke); cervicogenic headache (originating from the neck); glaucoma; headache following stroke or transient ischemic attack (TIA); space-
occupying lesions (e.g., brain tumour); subarachnoid hemorrhage or intracerebral hemorrhages; subdural hematoma; systemic/CNS vasculitides (e.g., systemic
lupus erythematosus); and others
Note: “sinus” headaches occur only in the presence of a sinus infection (fever, purulent nasal discharge)12
Medications (see Table 2)
Drugs Associated with Headache
Table 2 lists drugs that commonly cause headache as a side effect.
7,13,14,15
Table 2: Drugs Associated with Headache
Drugs associated with intracranial hypertensiona
Antibiotics minocycline, sulfamethoxazole/trimethoprim, tetracycline
Corticosteroids
Other cimetidine, isotretinoin, tamoxifen
Drugs with headache as a side effecta
ACEIs e.g., captopril
Antihypertensives, miscellaneous hydralazine, methyldopa
Beta-blockers e.g., atenolol, propranolol (also used for migraine prophylaxis)
Calcium channel blockers nifedipine
H2 antagonists e.g., cimetidine, ranitidine
Nitrates e.g., nitroglycerin
NSAIDs diclofenac, indomethacin (also used to treat certain types of headache)
Oral contraceptives and HRT (in some patients predisposed to migraine)
SSRIs citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline
Other caffeine (especially caffeine withdrawal), cyclosporine, danazol, latanoprost

ophthalmic drops,16 metronidazole
a
Most common drug-related causes (not exhaustive).
Abbreviations: ACEI = angiotensin-converting enzyme inhibitor; HRT = hormone replacement therapy; NSAID = nonsteroidal anti-inflammatory drug; SSRI = selective serotonin reuptake
inhibitor
Red Flags for Serious Headache
Severe/abrupt onset (“worst headache ever”)

Onset in middle age or older (>40 years)
Neurologic signs: stiff neck, focal signs, reduced consciousness
Systemic signs: appears ill, fever, nausea/vomiting (not explained by migraine or systemic illness)
Significant change in pattern of headaches: increased frequency and/or progressive severity
Nocturnal occurrence or on awakening in the morning; if patient consistently has headache on awakening or is awakened by a headache, brain tumour is a possible
cause; however, migraines sometimes occur on awakening
Onset with exercise or sexual activity (may be benign or serious)
Patient education is important in the management of headache. Provide patients with an explanation of their headache disorder and use printed materials to reinforce verbal
information. Reassure them (in some cases, once the diagnosis has been confirmed) that they do not have a serious underlying cause for headaches (e.g., brain tumour).
Establish realistic goals and expectations of treatment; explain benefits and limitations of various treatment options in collaboration with the patient's healthcare team.
Patients may also benefit from referral to self-help groups.11,14
Acute/Symptomatic Treatment
During a migraine attack, simple measures such as resting in a dark, quiet room and applying a cold cloth/ice pack to the head are helpful, although not evidence-based.
Sleep often alleviates migraine headaches.
Prevention
Migraine and other headaches are often triggered by 1 or more factors. Triggers vary among individual patients. Advise patients to identify and avoid the triggers
associated with their migraines. Lifestyle changes such as maintaining regular sleeping and eating schedules, reducing stress and limiting caffeine intake may reduce
the frequency of headaches, particularly migraine. A sudden decrease in caffeine consumption may lead to a withdrawal headache; caffeine may help alleviate headache
in some migraine sufferers. Ask patients to maintain a headache diary (available from www.headachenetwork.ca or www.migrainecanada.org), that includes food
ingested within 24 hours prior to an attack, to identify dietary migraine triggers.14 If feasible, discontinue drugs implicated in triggering a headache (see Table 2) on a trial
basis. Common migraine triggers are listed in Table 3.
9,14
Table 3: Migraine Triggers
Types of Triggersa Examples
Chemical Benzene, insecticides, perfumes or other strong odours.
Drugs See Table 2.
Environmental Weather changes (barometric pressure changes), bright/flickering lights, loud noise, strong odours
(e.g., perfume), cigarette smoke, travel across time zones.
Foods and beverages that contain nitrites, Aged cheeses, cured meats (e.g., hot dogs, bacon), chocolate, alcoholic beverages (especially red
monosodium glutamate (MSG), aspartame or wine), caffeine-containing beverages.
neurotransmitter precursors (e.g., tyramine, tyrosine, Missed or delayed meals can also trigger migraine.
phenylalanine)
Hormonal Menstruation, pregnancy (especially in first trimester), perimenopause.
Other Sleep-wake cycle alterations, stress/anxiety (or let-down from stress), intense activity/physical
exertion, sexual activity.
a Most common triggers are listed (not an exhaustive list).
Biobehavioural measures such as biofeedback, relaxation therapy, cognitive behavioural therapy and acupuncture may help to prevent migraine in some individuals.14
While aerobic exercise (e.g., 40 minutes 3 times weekly) may trigger a headache for some patients, in others it may reduce headache frequency and provide an option for
patients who cannot or choose not to take prophylactic medication.17
Controversial measures include chiropractic and other physical therapies, transcutaneous electrical stimulation, hypnosis, occipital or supraorbital nerve blockade and
homeopathic remedies.14,18
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Analgesic Products: Internal Analgesics and Antipyretics;
Herbal and Natural Health Products: Single Entity; Vitamin and Mineral Products: Single Entity.
Symptomatic Treatment
See Table 4 for information on drug therapy for acute headache.
Tension-type Headaches
Analgesics
Mild tension-type headache may not require treatment. Appropriate doses of simple analgesics (e.g., acetaminophen, ASA) or NSAIDs (e.g., ibuprofen, naproxen
sodium) will often alleviate tension-type headaches.2,11
Migraine Headaches
The goal of acute drug therapy for migraine headaches is to alleviate pain within 2 hours of treatment.10 Several agents may be tried before finding the most effective
therapy. Patients may need ≥1 medication depending on the migraine severity. Moderate to severe migraine attacks often require the use of triptans with or without
simple analgesics, and possibly antiemetics.10 Consider prophylactic therapy if migraine attacks have a significant impact on quality of life despite appropriate use of
acute medications or if frequency of attacks and reliance on acute medications puts patients at risk of MOH30 (see Preventive Therapy).
Analgesics
Mild to moderate migraine attacks may respond to adequate doses of simple analgesics (e.g., acetaminophen, ASA) or NSAIDs (e.g., ibuprofen, naproxen
sodium).2,11,26,31
There is a lack of evidence of efficacy for codeine (8 mg) in combination with ASA or acetaminophen (plus caffeine) in the treatment of migraine. It may be
considered if other options are ineffective or contraindicated. Recommended dosage is 1–2 tablets Q4H PRN in adults and 1–2 tablets up to QID in adolescents.
Side effects associated with codeine include constipation, sedation, dependence and tolerance. Codeine has been associated with an increased incidence of
congenital anomalies including cleft palate and inguinal hernias.21 To avoid MOH, these combination products should be used <10 days/month. Overuse of
caffeine can lead to withdrawal headache. Use codeine with caution in a breastfeeding mother: choose the lowest effective dose and limit treatment to less than
3–4 days.32 For more information on opioid use in this population, consult the Compendium of Pharmaceuticals and Specialties: Drug Use during Breastfeeding.
Unfortunately many migraine sufferers do not achieve adequate pain relief by relying exclusively on simple analgesics.33,34,35,36,37,38 Furthermore, most
published trials of nonprescription agents in migraine have systematically excluded patients with more severe attacks.
Triptans
Triptans or 5-HT1B/1D receptor agonists (e.g., almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan) are considered to be the
most efficacious agents for acute migraine treatment.39,40 They alleviate headache pain and migraine-associated symptoms (nausea/vomiting,
photophobia/phonophobia). In randomized controlled trials, all triptans have demonstrated efficacy in the treatment of acute migraine; however, individuals may
differ in their response to a particular triptan. The triptans are available in various formulations: subcutaneous injection (sumatriptan), oral tablets (all), orally
disintegrating tablets (rizatriptan, zolmitriptan) and intranasal (sumatriptan, zolmitriptan).41 If oral agents are not effective or cannot be used due to
nausea/vomiting, consider an intranasal formulation or the triptan showing the greatest efficacy—subcutaneous sumatriptan.10
The combination of an NSAID (e.g., naproxen sodium) and a triptan (e.g., sumatriptan) has better efficacy compared with either agent alone, and reduces
headache recurrence.42,43 A Cochrane review determined that the combination of naproxen sodium (500 mg) and sumatriptan (50 mg or 85 mg) was more
effective than monotherapy with naproxen sodium, sumatriptan or placebo for headache relief and being pain-free after two hours.44 Treating early, while pain
was still mild, was significantly better than treating when pain was moderate or severe;44 thus, encourage patients to treat the migraine as soon as possible.
[Evidence: SORT A] As some of the above formulations or strengths are not available in Canada (e.g., naproxen sodium 500 mg, sumatriptan 85 mg), prescribers
should offer the multi-drug combination of naproxen sodium (550 mg) and sumatriptan (50 mg) to the following patients:
patients whose response to triptan monotherapy is inadequate10,44 [Evidence: SORT A] or
patients who experience frequent headache recurrences after successful treatment with triptan monotherapy10 [Evidence: SORT A]
Ergotamine Derivatives
Nasal or injectable dihydroergotamine (DHE) has been shown to be effective for migraine.10,45 Oral ergot preparations (e.g., ergotamine tartrate; no longer
available in Canada) have limited efficacy and excessive side effects.10,46
Other Agents
In the emergency room, various parenteral agents may be used for treatment of severe migraine. Adjunctive antiemetics (e.g., metoclopramide), chlorpromazine,
prochlorperazine, ketorolac, dexamethasone or opioids (not considered first-line therapy) may be given with other agents such as DHE.10
Butalbital (in combination with ASA, caffeine and/or codeine) is sometimes used in the management of acute migraine, but has a very limited role due to the
potential for dependence, abuse, medication-overuse headache and the possibility of a withdrawal syndrome following discontinuation of high doses.10
Adjunctive drugs for the management of nausea/vomiting associated with migraine include dimenhydrinate (though there is a lack of evidence), domperidone,
metoclopramide or prochlorperazine.10
For further discussion of pharmacologic therapy for migraine, consult the Compendium of Therapeutic Choices: Headache in Adults; Headache in Children.
Treatment of medication-overuse headache (MOH) involves discontinuation of the drug(s) that are implicated, relief of withdrawal symptoms, use of migraine-
specific medications (adhering to recommended limits in frequency of use) to treat recurrent headaches, and initiation of prophylactic therapy (e.g., divalproex
sodium, propranolol, topiramate, tricyclic antidepressants). The causative agents are usually stopped abruptly or sometimes tapered, while titrating prophylactic
therapy. Advise patients not to discontinue high doses of butalbital-containing analgesics abruptly, since seizures may occur on withdrawal. Ideally, refer these
patients to a neurologist/headache specialist. Primary care healthcare practitioners can play a key role in preventing and managing MOH. Monitor the patient's use of
prescription and nonprescription medications, counsel on appropriate use of antimigraine medications and provide support to patients who are withdrawing from
medications.47,48,49,50,51,52
Preventive Therapy
Tension-type Headache
Most strategies to prevent tension-type headache are nonpharmacologic (see Nonpharmacologic Therapy). For disabling and/or chronic tension-type headache,
pharmacologic prophylaxis may be considered (e.g., amitriptyline, mirtazapine, nortriptyline, venlafaxine).53
Migraine
Prophylactic therapy is usually administered daily to reduce the frequency and severity of attacks in patients with migraine. Guidelines for migraine prophylaxis are
available from the Canadian Headache Society.30
Prophylactic migraine therapy is appropriate in the following circumstances:10,11,30
Migraine attacks (any number) that significantly impair normal activity or quality of life despite appropriate use of acute therapies
Optimal acute therapies have failed, are contraindicated or have produced serious side effects
Frequent attacks that result in the potential overuse of acute therapies and may lead to medication-overuse headache.
Prophylaxis is considered successful if headache frequency, or number of days with headache, is reduced by ≥50%. Typically only 1 preventive agent is used at a time;
however, neurologists may prescribe combinations of agents in resistant cases. Start medications at a low dose and titrate to the most effective tolerated dose. A
trial period of at least 2 months is needed to assess the efficacy of most prophylactic medications. If effective, prophylactic agents may be continued for 6–12
months, then tapered gradually (to assess ongoing need and prevent rebound headaches). Prophylactic therapy may be required for prolonged periods in some
patients. Consider the patient's concurrent medical conditions (e.g., hypertension, depression or obesity) and/or drug contraindications (e.g., beta-blockers are
contraindicated in patients with asthma) when selecting a prophylactic agent. Advise patients to keep a headache diary (available from www.headachenetwork.ca or
www.migrainecanada.org) to monitor their response to therapy.30
Preventive Agents
Medications used for migraine prophylaxis include beta-blockers without intrinsic sympathomimetic activity (e.g., propranolol, nadolol, metoprolol), tricyclic
antidepressants (e.g., amitriptyline, nortriptyline), calcium channel blockers (e.g., flunarizine, verapamil), serotonin (5-HT2) receptor antagonists (e.g., pizotifen),
valproic acid/divalproex sodium, topiramate, candesartan, lisinopril, gabapentin and NSAIDs (e.g., naproxen sodium 550 mg twice daily for 1 week per month for
menstrual migraine prophylaxis).10,11,30,53
For more information on preventive therapy, consult the Compendium of Therapeutic Choices: Headache in Adults; Headache in Children.
See Table 5 for information on natural health products used for migraine headache prophylaxis.
Butterbur (Petasites hybridus extract) 75 mg, and not 50 mg, was significantly more effective than placebo in a controlled trial that randomized patients with
migraine (n=245) to butterbur 50 mg, 75 mg or placebo twice daily.55 Sixty-eight percent of patients receiving butterbur 75 mg BID achieved ≥50% reduction in
attack frequency after 4 months compared with 49% for the placebo arm. Butterbur was well tolerated; the most frequently reported adverse events included mild
GI events, primarily burping. There have been rare reports of hepatotoxicity.54 Caution patients to avoid consuming any part of the Petasites plant other than
specific commercially prepared products that have had plant carcinogens and hepatotoxic alkaloids removed.
Coenzyme Q10 (300 mg/day) was well tolerated and superior to placebo in a small, randomized, controlled trial of migraine prophylaxis in 42 patients.57 Better
studies are needed to determine the efficacy of coenzyme Q10 in migraine prophylaxis.
The potential role of magnesium deficiency in the pathogenesis of migraine has been investigated. Prophylactic oral magnesium supplementation was effective
in 2 double-blind studies. The lack of response in a third study is thought to be due to the poor absorption of magnesium preparation used.58,59,60 In 1 study that
demonstrated the efficacy of magnesium, patients received magnesium 600 mg (24 mmol) daily in the form of trimagnesium dicitrate (not available in Canada; an
alternative may be magnesium citrate).58 More definitive, large-scale studies are needed to assess the role of magnesium in migraine prevention.
Riboflavin (vitamin B2) 400 mg daily for 3 months was compared with placebo for migraine prophylaxis in a randomized, double-blind trial with 55 patients.61
Approximately 50% of patients taking riboflavin had ≥50% reduction in frequency of attacks compared with 15% in the placebo arm. The exact mechanism of
action is not known but may be related to its effects on mitochondrial energy metabolism. It is thought that mitochondrial dysfunction, resulting in impaired
oxygen metabolism, may play a role in migraine pathogenesis. Only minor adverse effects (1 case each of diarrhea and polyuria) were reported in the riboflavin
group. Riboflavin can also cause insignificant yellow discoloration of the urine.61 In a randomized, double-blind study of 48 children with migraine, a high placebo
response rate suggested that riboflavin 200 mg daily is not effective in preventing migraine in children.62 Further large-scale and comparative studies are needed
to determine the efficacy of riboflavin in migraine prophylaxis.
Although feverfew (Tanacetum parthenium) has been used for migraine prophylaxis, evidence for its efficacy is conflicting and it appears to be no better than
placebo. Therefore, it is no longer recommended for migraine prophylaxis in the Canadian guidelines.30 Furthermore, discontinuation of feverfew can result in
post-feverfew syndrome, characterized by severe headache, insomnia, nervousness and joint pain.56
To prevent the development of MOH when treating primary headache disorders such as migraine or tension-type headache, use simple analgesics (e.g.,
acetaminophen, ASA) <15 days per month and combination analgesics or opioids <10 days per month. Frequent use (≥10 days per month) of ergot or triptan
medications can also result in MOH. Headache associated with overuse of analgesics tends to resemble a tension-type headache (migraine headaches can also be
superimposed) whereas triptan overuse manifests as increased migraine frequency.47,48,49,50,51,52
Acute/Symptomatic Therapy
Ideally, medications should relieve headaches (no pain or mild pain) and associated nausea/vomiting and photophobia/phonophobia within about 2 hours.10 Advise
patients to report any significant adverse effects to their healthcare practitioner (see Table 4 for side effects and drug interactions of nonprescription medications).
Preventive Therapy
Continue prophylactic medications for migraine for at least 2 months to determine efficacy. A ≥50% reduction in the frequency of migraine attacks is considered a good
response. Advise patients to record exercise, food intake, medication use and migraine attacks in a headache diary,4 and to report any medication adverse effects to
their healthcare practitioner (see Table 5 for side effects of natural health products for migraine prophylaxis).
Algorithms
Figure 1: Assessment and Management of Patients with Headache

a Limit use of simple analgesics (e.g., acetaminophen, NSAIDs) to <15 days/month and combination analgesics (e.g., acetaminophen with codeine) to <10 days/month.
b Limit use of ergot and triptan products to <10 days/month.
Drug Tables
Table 4: Drug Therapy for Treatment of Mild Tension-type and Migraine Headaches
NSAIDs ASA Adult: 975–1000 GI upset—usually the Increased risk of Use <15 days/month to avoid $
Aspirin, Coated mg pob only more common bleeding with MOH. Good evidence for efficacy
Aspirin, generics Pediatric (≥12 y): adverse effect when anticoagulants (e.g., in migraine (975–1000 mg).19
500–650 mg single doses are warfarin) or antiplatelet A meta-analysis of 3 trials
single dose used to treat acute drugs (e.g., clopidogrel). concluded that effervescent ASA
headache. May decrease effect of 1000 mg was as effective as
With continuous or antihypertensives. sumatriptan 50 mg for acute
frequent NSAID use: May decrease renal migraine.20
Cardiovascular: MI, clearance of lithium;
stroke, heart failure, Because of the possible risk of
monitor lithium levels
fluid retention, Reye's syndrome, ASA should not
when NSAID added.
hypertension. be used in the presence of viral
Increased risk of GI illness or fever in children.
CNS: Dizziness, bleeding when used with
drowsiness, Enteric-coated preparations will
SSRIs.
headache, tinnitus, result in a delayed onset of
confusion action.
(especially in the Pregnancy: Relatively safe in
elderly); CNS effects intermittent doses during first
may be dose related and second trimesters; avoid use
and respond to in third trimester (may be
decreased dosage. associated with prolonged
GI: Dyspepsia, gestation and labour, premature
epigastric pain, narrowing of ductus arteriosus,
nausea/vomiting, persistent pulmonary
diarrhea, gastric and hypertension of the newborn).21
duodenal ulcers, GI
bleeding.
Nephrotoxicity may
occur; avoid NSAIDs
in patients with
severe renal
impairment (ClCr
<30 mL/min).
Minor or serious
skin rashes, pruritus.
NSAIDs ibuprofen Adult: 400 mg GI upset—usually the Increased risk of Use <15 days/month to avoid $
Advil, Advil pob only more common bleeding with MOH.
Children/Pediatric, adverse effect when anticoagulants (e.g., Good evidence for efficacy in
Advil Junior Pediatric: single doses are warfarin) or antiplatelet
Children ≥6 migraine.22
Strength, Advil used to treat acute drugs (e.g., clopidogrel).
Liquid Gels, Motrin, months: 5–10 headache. May decrease effect of A meta-analysis concluded that
Motrin (Children's), mg/kg Q6–8H po With continuous or antihypertensives. ibuprofen at doses of 200 mg or
Motrin IB, Motrin PRN for frequent NSAID use: 400 mg is effective in rendering
symptom May decrease renal migraine sufferers pain-free at 2
Liquid Gels, Cardiovascular: MI, clearance of lithium;
generics management; stroke, heart failure, h; however, photophobia and
maximum 40 monitor lithium levels phonophobia improved only with
fluid retention, when NSAID added.
mg/kg/day; do hypertension. the 400 mg dose.23
not exceed adult Increased risk of GI
dose CNS: Dizziness, Pregnancy: Relatively safe in
bleeding when used with
drowsiness, intermittent doses during first
SSRIs.
headache, tinnitus, and second trimesters; avoid use
confusion in third trimester (may be
(especially in the associated with prolonged
elderly); CNS effects gestation and labour, premature
may be dose related narrowing of ductus arteriosus,
and respond to persistent pulmonary
decreased dosage. hypertension of the newborn).21
GI: Dyspepsia,
epigastric pain,
nausea/vomiting,
diarrhea, gastric and
duodenal ulcers, GI
bleeding.
Nephrotoxicity may
occur; avoid NSAIDs
in patients with
severe renal
impairment (ClCr
<30 mL/min).
Minor or serious
NSAIDs naproxen Adult: 500 mg GI upset—usually the Increased risk of Use <15 days/month to avoid $
Naprosyn, pob only more common bleeding with MOH.
Pediapharm adverse effect when anticoagulants (e.g., In studies showing efficacy in
Naproxen single doses are warfarin) or antiplatelet migraine, prescribed doses of
Suspension, used to treat acute drugs (e.g., clopidogrel). 500–825 mg were used.24
generics headache. May decrease effect of
With continuous or antihypertensives. Pregnancy: Relatively safe in
frequent NSAID use: intermittent doses during first
May decrease renal and second trimesters; avoid use
stroke, heart failure, in third trimester (may be
monitor lithium levels associated with prolonged
hypertension. gestation and labour, premature
Increased risk of GI narrowing of ductus arteriosus,
CNS: Dizziness, bleeding when used with persistent pulmonary
drowsiness, SSRIs. hypertension of the newborn).21
headache, tinnitus,
confusion
(especially in the
elderly); CNS effects
may be dose related
and respond to
decreased dosage.
GI: Dyspepsia,
epigastric pain,
nausea/vomiting,
duodenal ulcers, GI
bleeding.
Nephrotoxicity may
occur; avoid NSAIDs
in patients with
severe renal
impairment (ClCr
<30 mL/min).
Minor or serious
NSAIDs naproxen sodium Adult: 550 mg GI upset—usually the Increased risk of Use <15 days/month to avoid $
Anaprox, Aleve, pob only more common bleeding with MOH.
generics adverse effect when anticoagulants (e.g., In studies showing efficacy in
Recommended single doses are warfarin) or antiplatelet migraine, prescribed doses of
self-care dose: used to treat acute drugs (e.g., clopidogrel).
220 mg Q12H po 500–825 mg were used.24
headache. May decrease effect of
With continuous or antihypertensives.
frequent NSAID use: May decrease renal
stroke, heart failure, monitor lithium levels
hypertension.
Increased risk of GI
CNS: Dizziness, bleeding when used with
drowsiness, SSRIs.
headache, tinnitus,
confusion
(especially in the
elderly); CNS effects
may be dose related
and respond to
decreased dosage.
GI: Dyspepsia,
epigastric pain,
nausea/vomiting,
duodenal ulcers, GI
bleeding.
Nephrotoxicity may
occur; avoid NSAIDs
in patients with
severe renal
impairment (ClCr
<30 mL/min).
Minor or serious
Simple acetaminophen Adult: 1000 mg Potential liver (and Acetaminophen has been Limit use to <15 days/month to $
Analgesics Atasol pob (do not rarely kidney) reported to increase INR avoid MOH. Effective in
Preparations, exceed 4 g/day) dysfunction with in warfarin-treated childhood migraine.26 In adults, it
Tempra, Tylenol, chronic use of high patients.25 Check INR if is considered to be less effective
Tylenol Children's, Pediatric: 10–15 doses or with acute
mg/kg Q4–6H po acetaminophen ≥2 g/day than ASA or NSAIDs for
generics overdose. is used for ≥3
PRN for migraine.10
symptom consecutive days. Adjust 1 g dose shown to be effective
management; warfarin dosage as for migraine in adults, although
maximum 75 required. patients with severe migraine
mg/kg/day; do were excluded.27,28
not exceed adult
Pregnancy: Relatively safe during
dose
all trimesters; considered to be
analgesic of first choice during
pregnancy.21,29
a Cost per dose; includes drug cost only.

b In acute migraine, only single doses have been studied in randomized controlled trials.
Abbreviations: MOH = medication-overuse headache; NSAID = nonsteroidal anti-inflammatory drug
Legend: $ <$1
Table 5: Natural Health Products for Prevention of Migraine Headaches
Natural butterbur Adult: 75 mg BID po Generally well No significant interactions. Good evidence for efficacy in $$$
Health Pediatric: No tolerated; mild adults.55
Products recommendations; some gastrointestinal Derived from Petasites hybridus
evidence for safe use in events (mainly root extract; product should be
children 6–17 y for up to burping). standardized to contain a
4 months Rare reports of minimum of 15% petasins
hepatotoxicity.54 (e.g., Petadolex—Weber &
Weber, GmbH & Co, Germany).
Caution patients against
consuming any part of
Petasites plant in any form
other than commercially
prepared products, in which
plant carcinogens and
hepatotoxic alkaloids have
been removed.
Preparations containing
hepatotoxic alkaloid might be
teratogenic and hepatotoxic.
Safety has not been
established in pregnancy,
breastfeeding, or children <6
years.56
Natural coenzyme Adult: 300 mg/day po in Generally well May have additive blood One small trial showed efficacy $$
Health Q10 3 divided doses tolerated; GI pressure lowering effects when in adults.57
Products Pediatric: No effects (<1%; used with antihypertensive May take up to 3 months for
recommendations; some minimized by agents. significant benefit.
evidence of efficacy in giving in divided May reduce anticoagulant
children who have low doses 2 or 3 effects of warfarin. Monitor Insufficient data regarding use
levels of coenzyme Q10 times daily). patient's INR closely. in pregnancy.
May lower efficacy of

chemotherapeutic agents (e.g.,
doxorubicin; preliminary
evidence).
Minerals magnesium Adult: 300 mg (elemental Generally well May decrease absorption of Conflicting evidence for $
magnesium) BID po tolerated; bisphosphonates (e.g., efficacy.58,59,60
Pediatric: No diarrhea, GI alendronate, risedronate), Some magnesium salts are
recommendations; some upset. tetracyclines or quinolone poorly absorbed; suggest
evidence of efficacy in antibiotics (e.g., ciprofloxacin, citrate salt.
children levofloxacin, moxifloxacin);
separate administration by at Considered reasonably safe to
least 2 h. use in pregnancy.
Vitamins riboflavin Adult: 400 mg/day po Generally well No significant interactions. One small trial in adults $
Pediatric: Insufficient tolerated; yellow showed efficacy.61
evidence discoloration of Lack of efficacy in pediatric
urine (benign).
migraine prophylaxis.62
Use in pregnancy: safety of
high-dose therapy not shown
to be safe but not considered
teratogenic.
a
Cost per month; includes drug cost only.
Legend: $ <$10 $$ $10–20 $$$ $20–30
Resource Tips
Canada. Canadian Headache Society. Available from: www.migrainecanada.org.
Canada. Headache Network Canada. Available from: www.headachenetwork.ca (bilingual—English and French).
Ontario. Help for Headaches. Available from: www.headache-help.org.
U.S. American Committee for Headache Education, American Headache Society. Available from: www.achenet.org.
Suggested Readings
Becker WJ, Findlay T Moga C et al. Guideline for primary care management of headache in adults. Can Fam Physician 2015;61:670-9.
Evers S, Marziniak M. Clinical features, pathophysiology, and treatment of medication-overuse headache. Lancet Neurol 2010;9:391-401.
Purdy RA. Headache in adults. In: Jovaisas B, ed. Compendium of therapeutic choices: CTC 7. 7th ed. Ottawa: Canadian Pharmacists Association; 2014. p. 211-28.
Worthington I. Migraine headache: management strategies and optimizing therapy for acute attacks. Pharm Pract 2014;1:23-9.
Worthington I. Migraine prophylaxis: drug selection and treatment strategies for individual patients. Pharm Pract 2012;28:28-34.
References
Headache
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients. Once printed there is no quarantee the information is up-to-date. [Printed on:
08-09-2017 01:22 PM]
Headache—What You Need to Know
Headache is very common. Some headaches will go away after a short time without treatment, or with a nonprescription pain
reliever. Other headaches (migraines) may be more severe and you may need to have treatment prescribed by a healthcare
practitioner. Most headaches are not caused by serious health problems.
What should you do about headaches?
Tension-type headaches
The most common type of headache is called a “tension-type headache”. This kind of headache may be caused
by many things, not only tension. You may get a tension-type headache if you have a cold or the flu.
The pain is usually mild to moderate. It may be on both sides of the head or across the forehead. It often feels
like there is tightness or pressure in your head and sometimes in the shoulders and back of the neck.
The pain usually goes away on its own. Pain relievers such as ASA, acetaminophen, ibuprofen or naproxen
sodium might help. If you have this kind of headache often (more than 15 times in 1 month), seek medical
advice.
Migraine headaches
Migraine headaches are fairly common. Migraine headaches are more common in women than in men.
Migraines tend to run in families. Both children and adults can get migraines.
Migraine headaches usually occur on 1 side of the head. Some people, especially children, feel pain on both
sides of the head.
The pain is usually moderate to severe and throbbing. Physical activity tends to make the pain worse.
A person may have other symptoms in addition to the pain. For example:
nausea or vomiting, or both
sensitivity to light and sound
a visual sensation that sometimes occurs just before the headache. This is called an aura and may appear
as flashes or bursts of light, zig-zag lines, dark spots surrounded by light.
What triggers migraine headaches?
Many things can trigger a migraine headache. Triggers are different for each person. Keep a diary about your headaches to
help you figure out what causes them. Some common triggers are:
Food (such as aged cheeses, cured meats, chocolate, red wine)

Caffeine (from coffee, tea, some carbonated or energy drinks, etc.—having too much or suddenly reducing the
amount you normally have)
Hormones (in women—at the time of your monthly menstrual period or during menopause)
Chemicals (such as MSG in foods)
Environment (changes in weather, bright lights, loud noises, strong odours, cigarette smoke)
Other factors (such as anxiety/stress, too much or too little sleep, not eating regularly)
How can you treat a migraine?
Prevention
Avoid foods and other things that may trigger a migraine.

Some people find that biofeedback, relaxation, acupuncture and cognitive behavioural therapy help to prevent
migraine headaches.
Mild Migraine Headaches

Many patients get relief by lying down in a dark, quiet room and applying a cold cloth or ice pack to the head.
Falling asleep often provides relief as well.
Pain relievers such as ASA, acetaminophen, ibuprofen or naproxen sodium might help.
It is important not to use pain relievers more than 15 days per month, or products containing codeine or
caffeine more than 10 days per month. If you use them more often, you may begin to get more frequent or daily
headaches called “medication-overuse headache”.
Seek medical advice if you have headaches every day or almost every day. You may be asked to stop taking pain
relievers for a while. If your headaches are severe, you will usually be prescribed other medication.
Moderate or Severe Migraine Headache
Seek medical advice. You may need a prescription medication.

It is important not to use migraine therapy such as triptans and ergot medication more than 10 days per month.
You may need medication to treat nausea. Dimenhydrinate (Gravol) may help to reduce nausea. You may also
need prescription medication such as domperidone or metoclopramide to treat nausea or vomiting.
Go to an emergency room if you have a very severe headache and/or severe vomiting that starts suddenly.
Consider going to an urgent care facility if your migraine isn’t relieved by medication.
You may be prescribed medication that you take every day to prevent migraines that happen often, that are
severe, or that last a long time.
Certain vitamins or herbal remedies may help to prevent migraines. Talk to a healthcare practitioner before
taking any medication to prevent migraines.
Other Headaches
There are many other less common types of headache. Seek medical advice to find out what is causing your headache. Many
people who think they have “sinus” headaches are actually suffering from migraine or another type of headache. Sinus
headaches only occur if a sinus infection is present.
Severe, New or Unusual Headaches
Some headaches may be the first sign of a more serious health problem. Go to the emergency room or an urgent care facility
if:
You suddenly have a severe headache that is worse than any you have had before.
You have symptoms such as fever, stiff neck, drowsiness, confusion, seizures or a general feeling of weakness,
as well as a headache.
Seek medical advice as soon as possible if:
You experience a new or unusual type of headache.

There is a change in your usual headache pattern—for example, headaches that happen more often or become
severe.
You start to have headaches in middle age or later (age 40 or over).
For more information on migraine headaches, visit these websites:
Canadian Headache Society. Available from: www.migrainecanada.org
American Migraine Foundation. Available from: americanmigrainefoundation.org/.
Heat-Related Disorders
Dorothy Tscheng, BScPhm, CGP

Date of Revision: August 2015
Introduction
Heat-related illnesses and mortality are preventable.1 There is a wide spectrum of heat-related disorders,
ranging from mild heat edema or heat rash to potentially fatal heat stroke. With timely treatment, the
mortality rate for heat stroke is around 10%, but when treatment is delayed, death can occur in up to 80% of
cases.2 The incidence of these disorders increases with higher temperature and humidity, e.g., during an
extended heat wave. A study of hospital admissions during heat waves found that older adults had a 2.5-
fold increase in risk of being hospitalized for heat stroke compared with non-heat wave periods.3 Deaths
due to heat-related disorders are under-reported as cardiovascular and respiratory illnesses also increase
during heat waves and may not be attributed directly to the heat.4 Because increases in atmospheric
greenhouse gas levels are leading to more frequent and intense heat events, the incidence of heat stress
disorders is likely to increase.5 Healthcare practitioners need to be aware of the consequences of these
environmental conditions and to actively promote preventive measures.
Pathophysiology
The body's thermoregulatory centre (the hypothalamus) is responsible for the maintenance of core body
temperature (approximately 37°C).2,6 The body acquires heat through different sources or processes
including shivering, thyrotoxicosis, physical activity and high ambient temperatures. Heat illness results
from an imbalance of heat generated within and absorbed by the body and its ability to dissipate excessive
heat.1,2,6 Because heat dissipation occurs primarily through the skin, preventing or correcting a heat
imbalance requires normal skin condition as well as sufficient cardiac output and blood volume to maintain
adequate blood flow to the skin.2,7
The body eliminates heat by 4 different mechanisms:2,6
Evaporation of moisture from the skin or respiratory tract results in loss of heat. In low humidity
conditions, evaporation is an effective mechanism of heat dissipation. This mechanism becomes more
important at higher ambient temperatures when evaporation of perspiration is key
Radiation is the transfer of heat through electromagnetic waves. It accounts for about 65% of heat loss
when ambient temperature is lower than body temperature. At higher ambient temperatures, heat gain
can result
Conduction is the transfer of heat through physical contact with a cooler object. At higher
temperatures, conduction is the least effective of the 4 mechanisms
Convection is the transfer of heat to the air and vapour. Both air flow and vasodilation contribute to
heat loss by convection.
A reduction in the efficacy of any of the above mechanisms can increase the risk of developing a heat-
related illness. As ambient temperature and humidity increase, heat dissipation becomes less efficient. If
not treated in time, excessive body temperature initiates a series of processes that leads to the collapse of
the cardiovascular system, multiorgan failure and potentially death.2
There are 2 types of heat stroke: classic and exertional. Hallmark symptoms for both include an elevated
body temperature of over 40°C (measured rectally as this is the most reliable method to determine body
temperature compared with oral or tympanic methods) and changes in mental status. Older individuals with
predisposing health risks who are exposed to poor environmental conditions usually present with classic
heat stroke. These patients differ from exertional heat stroke sufferers in that they typically present with hot,
dry skin and the increase in core body temperature is relatively less pronounced.1,2 This type of heat stroke
can develop over several days.1
Exertional heat stroke, as its name depicts, usually occurs in younger, healthy individuals who have
participated in strenuous physical activity. Competitive athletes and military personnel are population
groups that typically develop this form of heat stroke, distinguished by the presence of sweat and a more
marked increase in core body temperature.1,2 Symptoms can occur rapidly, often within a few hours of the
activity.1
Risk Factors
Several population groups are at risk of developing heat-related disorders:1,2,7,8
Infants and young children

Older adults
Outdoor labourers (e.g., firefighters, military personnel)
Competitive athletes
Individuals in poor socioeconomic situations
Table 1 outlines risk factors for development of heat-related illness.1,2,3,5,9,10,11,12
Children are thought to be at increased risk of heat-related illnesses due to physiologic and anatomical
differences (e.g., reduced sweating due to a greater surface area to body mass ratio, immature
thermoregulatory system) and a reduced thirst response to dehydration as compared with healthy
adults.2,7,8 However, some recent information suggests that these differences are not as significant,
especially in older children. Infants and preschool children are still considered an at-risk group partly due
to the dependence of young children on others to ensure they stay hydrated and are removed from risky
environments.7 Regardless of the reason, caregivers need to be mindful of the potential risks when
exposing this population to hot and humid environments.
Older adults are predisposed to heat illnesses because of comorbid illnesses (including cardiovascular
limitations), multiple medications and poor thermoregulatory response.2,3,8 Social and behavioural
factors such as home containment (not leaving the home on a daily basis), social isolation, bed
confinement and an inability to provide self-care put this population at particular risk, especially in more
dependent older adults.3,8,9
In addition to heat-related disorders, cardiovascular and respiratory deterioration have long been
identified as consequences of heat waves. An association has been found between heat exposure and
higher hospital admission rates in older adults for fluid-related disorders, renal failure, urinary tract
infections and septicemia.3 The risk of these additional health consequences increased as the period
and intensity of the heat wave increased and remained elevated for up to 5 days after the heat wave.
Table 1: Common Risk Factors for Developing Heat-related Illnesses

Demographic/Medical Factors Behavioural/Environmental Factors
Age (young children, elderly) Lack of acclimatization
Alcoholism Lack of air conditioning or ventilation
Bed confinement Lack of breaks during exercise
Cardiovascular disorders Living in urban areas with greater number of
Dehydration paved surfaces and buildings
Dermatologic diseases such as scleroderma, Poor physical condition

miliaria Social isolation
Fever Strenuous activity in hot, humid conditions
Homelessness Unable to perform self-care
Hyperthyroidism Use of heavy clothing or equipment
Lower socioeconomic environment
Obesity
Peripheral vascular disease
Psychiatric disorders
Pulmonary disorders
Use of medications listed in Table 2
Medication-related Causes
Medications listed in Table 2 can predispose patients to heat-related disorders through various
mechanisms that include:1,6,7,9,10,13,14,15
Inhibition of sweat excretion (anticholinergic effects and hypovolemic causes)

Vasoconstriction of cutaneous vessels
Disruption of hypothalamic thermoregulation
Increase in heat production
Increased fluid loss through diarrhea or vomiting leading to dehydration
Table 2: Medications that can Predispose to Heat-related Illnesses

Mechanism Drug/Classa
Disruption of hypothalamic antipsychotics

regulation amphetamines (including MDMA/“ecstasy”)
Increased heat production excessive thyroid medication

sympathomimetics
Mechanism Drug/Classa
Reduction of sweat alcohol

excretion (either by direct anticholinergics
effects on the skin/sweat
glands or through reduced antihistamines
blood flow to the skin) antiparkinsonian (anticholinergic) agents
antipsychotics (anticholinergic)
belladonna alkaloids
beta-blockers
calcium channel blockers
cholinesterase inhibitors
creatineb
diuretics
laxatives
lithium
topiramate
tricyclic antidepressants
Vasoconstriction of alpha-agonists
cutaneous vessels monoamine oxidase inhibitors
sympathomimetics (including ephedrine, cocaine,
amphetamines, diet products containing ma huang)
a In addition, any medication or substance (e.g., tranquilizers, cocaine) that can alter a person's behaviour,
including the perception of their environment or need for proper hydration, may increase the risk of heat-related
illnesses in the right conditions.10
b Evidence has been contradictory; however, use of creatine ≤28 days or when exercising ≤60 min does not
appear to influence hydration status or temperature regulation.16 It is not clear whether creatine use >28 days or
with exercise >60 min affects thermoregulation.
Goals of Therapy
Prevention of any heat-related disorder is the foremost goal. However, once an individual has experienced
symptoms, the goals of therapy are:
Reduce mortality
Prevent long-term consequences
Normalize body temperature
Reduce and eliminate symptoms
Patient Assessment
Information about the assessment of patients with a suspected heat-related disorder can also be found in
Figure 1.1,2,17
Symptoms of various heat-related problems present differently depending on the degree or stage of the
illness. Patients' complaints range from edema in the feet to more serious concerns of confusion or coma.
The spectrum of disorders is described (from mildest to most severe) in Table 3.1,2,13,18,19,20
If any acute neurologic symptoms (altered mental status, confusion or hallucinations, seizures) are present,
the person must be taken to the hospital immediately, preferably in an air-conditioned vehicle, to be
assessed and treated. In addition to heat stroke, differential diagnosis includes meningitis, neuroleptic
malignant syndrome, hyperthyroidism, encephalopathy, tetanus, delirium and overdose of various
substances including cocaine and salicylates.2
Other hyperthermia syndromes include neuroleptic malignant syndrome (NMS) and malignant hyperthermia
(MH); however, the underlying causes are drug related rather than heat related. Both NMS and MH present
with hyperthermia and muscle rigidity but have different etiologies; NMS is induced by antipsychotics and
MH by inhaled anesthetics or succinylcholine (post-surgery) in susceptible individuals.
For further discussion of management of NMS and MH, consult the Compendium of Therapeutic Choices:
Thermoregulatory Disorders in Adults.
Table 3: Spectrum of Heat-related Disorders: Symptoms and Therapy

Type of Illness Features/Symptoms Therapy
Heat rash “Prickly heat” that appears as a group Retreat to a cooler and less humid
of small blisters or rash environment
Due to irritation from excessive Keep the area dry
sweating
Usually located on the neck, upper
chest, under the breasts, in the groin
area or in elbow creases
Heat edema Edema in the extremities from Elevate feet or hands

transient vasodilation of vessels, No specific treatment
sodium and water retention and with
prolonged standing Prevention with acclimatization
More frequent during the summer
months
Heat cramps Thought to be due to water and Stop activity and rest in a cool,
sodium depletion shaded area
Cramps in muscles of the arms, legs Rehydrate with an oral rehydration
and stomach are most common solution containing glucose and
Warning sign of heat exhaustion sodium
Common in athletes Lightly stretch or massage affected

muscles
Avoid heavy activity for a few hours
See healthcare practitioner if no
improvement in 1 h or if symptoms
worsen
Heat syncope Dizziness Stop activity and rest in a cool,

Fainting episode shaded area
Patients often recover quickly after
falling to the ground (secondary to
fainting)
Slowly get up from a sitting or laying
position
Type of Illness Features/Symptoms Therapy
Heat exhaustion Weakness Stop activity and rest in a cool,

Nausea and/or vomiting shaded area
Tachycardia, hypotension Rehydrate with oral rehydration

solution
Fatigue
Recovery is usually quick, within 2–3
Dizziness h
Headache
Slightly elevated core body
temperature (up to 40°C)
Fainting
Reversible, but can lead to heat stroke
if untreated
Heat stroke Medical emergency—can result in Call 911—take patient to emergency

death room as soon as possible
Similar to heat exhaustion with the In the interim:
added feature, in most cases, of − stop activity immediately and rest
neurologic symptoms such as: in an air-conditioned environment (or
− altered mental status if not possible, a cool, shaded area)
− hallucinations − remove excessive clothing
− seizures − rehydrate
− confusion − ensure good air circulation around
− coma patient
Loss of the − ataxia − cool the body (on the way to the
ability to hospital) with ice water towels or
Other symptoms include hot, dry skin packs to the groin, neck, axillae and
coordinate Core body temperature above 40°C head
muscular Leads to hepatic and renal failure, CNS
movement. injury, coagulopathy and
cardiovascular collapse
Prevention
Prevention of heat-related illnesses is the primary goal. The first step in prevention is the identification of
individuals at risk and keeping a careful watch over them during heat waves. Healthcare practitioners can
offer proactive education and tips for these population groups, and when possible could check on identified
at-risk patients during heat waves.8
If possible, remove these individuals to an air-conditioned location and encourage them to participate in
social activities. Both have been shown to lower the risk of heat-related deaths during heat waves. Fluid
intake should be increased, without waiting for the appearance of thirst.21 Other potentially helpful
measures include taking extra showers or baths.11
Environment Canada's Humidex tables help predict environmental situations where the risk of heat stroke is
increased and vigilant monitoring of at-risk individuals is indicated. The Humidex tables can be found at
www.ec.gc.ca/meteo-weather/.
Health Canada has a toolkit intended for use by public health and emergency management officials to warn
Canadian residents about impending heat events. Healthcare practitioners may find many aspects of the
toolkit useful in developing a communication plan for their own patients and reinforcing the public health
message. The toolkit can be found at www.hc-sc.gc.ca/ewh-semt/pubs/climat/heat-chaleur/index-eng.php.
If outdoor activities cannot be avoided during periods of high temperature and humidity, the following
strategies are recommended to help reduce the risk of heat-related disorders:
Ensure proper hydration before the activity and drink cool fluids (approximately 500 mL to 1 L) during
each hour of heavy exercise.18,19 Oral rehydration solutions or sport drinks are useful as they contain
sodium and glucose that are lost during exercise. Thirst should not be relied upon as a reminder to
drink.2 It is important to remind people of salt and sugar content and to avoid use of sports drinks in
those patients with diabetes, hypertension, heart failure, renal failure or fluid restrictions
Stay out of the sun if possible. Take 10- to 20-minute breaks per hour of activity, either in the shade or
in an air-conditioned environment19,22
Avoid strenuous outdoor activities during peak sun hours (10 a.m. to 3 p.m.)
Wear light-coloured, lightweight clothing, including a wide-brimmed hat18
Acclimatize to the environment. Gradual exposure to ambient conditions can prevent heat-related
illnesses. The average adult should start at about 50% of expected activity in the environment,
increasing gradually to 80% over the next few days. However, the recommendation for inexperienced
workers is to start at 20% of expected activity and increase it by 20% daily. Up to 10–14 days of
exposure is required for full acclimatization in a hot environment.6,20,22 There is no consensus on how
to acclimatize children.22
Figure 2 provides a step-wise approach to aiding patients in the prevention of heat-related disorders.
It is imperative to address heat stroke immediately as delaying treatment results in poorer patient
outcomes.2 After seeking medical attention, the first priority is to move the patient to a shaded or preferably
air-conditioned environment and to cool the patient using external methods such as cool compresses
applied to the groin, neck, axillae and head. Increase air flow around the patient and promote evaporation by
removal of unnecessary clothing, use of fans and misting with moderate temperature water.1,2 Cold water
immersion has been shown to reduce morbidity and mortality in exertional heat stroke.1 However, in the
elderly and those with comorbidities and in situations where cold water immersion is not available, other
cooling methods as described above should be used. Internal cooling methods, such as cold water irrigation
to the stomach or rectum, are used in hospital as necessary.1
Other types of heat-related illnesses are not considered emergent and can be addressed appropriately
depending on severity. Table 3 outlines treatment options for various heat-related disorders.
Medications, such as antipyretics, do not help reduce the body's internal temperature and should not be
used. Although not the mainstay of therapy, medications can be helpful in treating some of the
complications of heat stroke. Benzodiazepines such as diazepam are used to treat seizures and control
shivering. Barbiturates have also been used for seizures, if benzodiazepines are not effective. Mannitol is
used to promote osmotic diuresis and prevent or treat renal failure in patients with rhabdomyolysis.2
Dantrolene is a muscle relaxant that has been evaluated for the treatment of heat stroke, but has not proven
to be effective. Dobutamine is the drug of choice for circulatory support.2,23
Monitoring by friends and family of individuals at risk of developing heat-related disorders is a critical
preventive strategy. Healthcare practitioners can play an important role by ensuring patients and caregivers
are able to recognize symptoms that require intervention or medical attention.
For those involved in outdoor activities, proper hydration (see Prevention) is important as thirst is an
unreliable sign of body fluid loss. Aim for maintaining light yellow urine.
The extent of recommended monitoring of patients who have suffered a heat-related illness depends on the
severity of the illness. Patients with heat exhaustion should avoid further heat exposure for 24–48 hours
after even a mild injury.1,20 Heat stroke patients require more intensive monitoring after hospital discharge
to manage potential complications, such as chronic renal failure and other organ damage.
Algorithms
Figure 1: Assessment of Patients with Heat-related Disorders
Figure 2: Approach to Implementing Preventive Strategies for Heat-related Disorders

a
See Environment Canada’s Weather Alerts, available at www.weather.gc.ca/mainmenu/alert_menu_e.html
b See Healthy Canadians: Extreme heat – heat waves, available at www.healthycanadians.gc.ca/healthy-living-vie-
saine/environment-environnement/sun-soleil/heat-extreme-chaleur-eng.php
Suggested Readings
Becker JA, Stewart LK. Heat-related illness. Am Fam Physician 2011;83:1325-30.
Health Canada. Acute care during extreme heat. Recommendations and information for health care workers.
Available from: http://www.hc-sc.gc.ca/ewh-semt/pubs/climat/actue_care-soins_actifs/index-eng.php.
Kenny GP, Yardley J, Brown C et al. Heat stress in older individuals and patients with common chronic
diseases. CMAJ 2010;182:1053-60.
Tscheng D. Heat-stroke and medications. Can Pharm J 2000;133:30-2.
References
1. Becker JA, Stewart LK. Heat-related illness. Am Fam Physician 2011;83:1325-30.

2. Medscape by WebMD. Helman RS, Habal R. Heatstroke. Updated May 1, 2015. Available from:
emedicine.medscape.com. Accessed June 2, 2015. Registration required.
3. Bobb JF, Obermeyer Z, Wang Y et al. Cause-specific risk of hospital admission related to extreme
heat in older adults. JAMA 2014;312:2659-67.
4. Patz JA, Frumkin H, Holloway T et al. Climate change: challenges and opportunities for global
health. JAMA 2014;312:1565-80.
5. Public Health Agency of Canada. Climate change and public health factsheets. Modified August 11,
2015. Available from: phac-aspc.gc.ca/hp-ps/eph-esp/fs-fi-a-eng.php. Accessed 10 March 2016.
6. Moreau TP, Deeter M. Heatstroke–predictable, preventable, treatable. JAAPA 2005;18:30-5.
7. Xu Z, Etzel RA, Su H et al. Impact of ambient temperature on children’s health: a systematic review.
Environ Res 2012;117:120-31.
8. Groot E, Abelsohn A, Moore K. Practical strategies for prevention and treatment of heat-induced
illnesses. Can Fam Physician 2014;60:729-30.
9. Tscheng D. Heat-stroke and medications. Can Pharm J 2000;133:30-2.
10. Martinez M, Devenport L, Saussy J et al. Drug-associated heat stroke. South Med J 2002;95:799-802.
11. Bouchama A, Dehbi M, Mohamed G et al. Prognostic factors in heat wave related deaths: a meta-
analysis. Arch Intern Med 2007;167:2170-6.
12. Crowley RA; Health and Public Policy Committee of the American College of Physicians. Climate
Change and Health: A Position Paper of the American College of Physicians. Ann Intern Med 2016.
[Epub ahead of print].
13. Bailes JE, Cantu RC, Day AL. The neurosurgeon in sport: awareness of the risks of heatstroke and
dietary supplements. Neurosurgery 2002;51:283-6.
14. de Carolis P, Magnifico F, Pierangeli G et al. Transient hypohidrosis induced by topiramate. Epilepsia
2003;44:974-6.
15. Health Canada. Acute care during extreme heat. Recommendations and information for health care
workers. Available from: http://www.hc-sc.gc.ca/ewh-semt/pubs/climat/actue_care-
soins_actifs/index-eng.php. Accessed April 22, 2016.
16. Lopez RM, Casa DJ, McDermott BP et al. Does creatine supplementation hinder exercise heat
tolerance or hydration status? A systematic review with meta-analyses. J Athl Train 2009;44:215-23.
17. Kenny GP, Yardley J, Brown C et al. Heat stress in older individuals and patients with common
chronic diseases. CMAJ 2010;182:1053-60.
18. Centers for Disease Control and Prevention. Frequently asked questions (FAQ) about extreme heat.
Available from: emergency.cdc.gov/disasters/extremeheat/faq.asp. Accessed April 22, 2016.
19. Government of Canada. Extreme heat—heat waves. Available from:
www.healthycanadians.gc.ca/health-sante/environment-environnement/sun-soleil/heat-extreme-
chaleur-eng.php. Accessed April 22, 2016.
20. American College of Sports Medicine, Armstrong LE, Casa DJ et al. American College of Sports
Medicine position stand. Exertional heat illness during training and competition. Med Sci Sports
Exerc 2007;39:556-72.
21. Hajat S, O'Connor M, Kosatsky T. Health effects of hot weather: from awareness of risk factors to
effective health protection. Lancet 2010;375:856-63.
22. Larsen T, Kumar S, Grimmer K et al. A systematic review of guidelines for the prevention of heat
illness in community-based sports participants and officials. J Sci Med Sport 2007;10:11-26.
23. McNamara R, Ryan D, McCarthy G. Towards evidence based emergency medicine: best BETs from
the Manchester Royal Infirmary. Bet 4: in patients with classic heat stroke does adding treatment
with dantrolene improve outcome? Emerg Med J 2008;25:441-2.

Heat-related Illness
Heat-Related Illness—What You Need to Know
What is a heat-related illness?
Your body has ways to keep itself cool when the weather is hot or if you are exercising. When your body has
difficulty keeping cool, you may develop a heat-related illness such as heat cramps or something more serious
such as heat stroke.
Awareness is the key to preventing heat-related illness before it happens.
What are the warning signs of a heat-related illness?
The different forms of heat-related illnesses present differently. The 2 most important illnesses to be aware of are heat
exhaustion and heat stroke. Heat exhaustion can lead to heat stroke if not treated and heat stroke is a medical emergency.
The symptoms of heat exhaustion include (but are not limited to):
Headache
Nausea, vomiting or both
Muscle weakness or cramps
Dizziness
Sweating
The symptoms of heat stroke include (but are not limited to):
Red, hot dry skin (for classic heat stroke)

High core body temperature (>40°C)
Nausea
Confusion
Unconsciousness
What are some factors that increase the risk of heat-related illness?
Age (young children, elderly)

Certain chronic diseases, e.g., alcoholism; heart, kidney, lung, psychiatric or thyroid disease; obesity
Dehydration
Medications (e.g., antidepressants, antihistamines, antipsychotics, diuretics, drugs for overactive bladder or
Parkinson disease)—talk to your pharmacist about your own medications
Activity in hot, humid conditions
Lack of breaks during exercise
Lack of air-conditioning or ventilation
Living in cities and surrounding suburbs where there is a lot of concrete and pavement
How can you prevent heat-related illness?
If possible, avoid strenuous outdoor activities when the sun is hottest (between 10 a.m. and 3 p.m.).
Try to stay in the shade. If you have to stay in direct sun, wear loose-fitting, light-coloured clothing.
Take several breaks from your activity.
Drink plenty of fluids before, during and after any outdoor activity. Limit the amount of coffee, tea, cola and
alcoholic beverages you drink.
What should you do if you do not feel well?
Rest in the shade or in an air-conditioned building if possible.

Take off as much clothing as possible.
Drink water or oral rehydration fluids.
Wet yourself with cool water.
Get medical attention or call 911 if you are not urinating (peeing) or sweating, if you vomit several times, or if
you start to feel confused.
What should you do if you are at risk of a heat-related illness?
Let your family and friends know what symptoms to watch for. They can help you in case you develop
symptoms and can make sure you get the help you need.
Wear a MedicAlert identification bracelet or something similar.
Tinnitus

Pathophysiology
Although tinnitus can occur at any age, it is less common in children and most common in the elderly.
Hearing loss is the most important risk factor for development of tinnitus.1 Objective tinnitus is caused by a
sound produced within the head due to either vascular (e.g., arteriovenous malformations, carotid stenosis,
valvular heart disease, states of high cardiac output and other conditions causing turbulent blood flow),
mechanical (e.g., palatal myoclonus, patulous eustachian tube) or spontaneous (spontaneous otoacoustic
emissions) causes.2 Subjective tinnitus, which is more common, is the perception of sound or noise without
any external stimulation. Causes include otologic (e.g., noise-induced hearing loss, presbycusis, impacted
cerumen, Meniere’s disease), neurologic (e.g., head injury, multiple sclerosis), infectious (e.g., otitis media,
sequelae of meningitis), drug-related (e.g., adverse effect of loop diuretics, salicylates, aminoglycosides)
and other (e.g., temporomandibular-joint dysfunction) factors.2
Tinnitus can be described as buzzing, hissing, cricket-like sounds, ringing, whistling, humming or a
combination of these.2,3 It can also occur as continuous, intermittent or pulsatile tinnitus.3 Tinnitus can
have a major impact on the quality of a patient's life with symptoms such as frustration, annoyance,
insomnia, anxiety, depression, irritation and difficulty concentrating, in addition to the “ringing in the ears”.3
The pathophysiology is incompletely understood; however, central mechanisms are involved. A distributed
tinnitus brain network, including sensory auditory areas and cortical regions involved in perceptual,
emotional mnemonic, attentional and salience functions, has been hypothesized.3
Goals of Therapy
Treat the underlying medical condition if possible
Correct hearing loss if correctable
Reduce or eliminate tinnitus, although this is not usually possible
Improve the patient's quality of life
Patient Assessment
Assess potential drug-related causes of tinnitus and address any potential drug causes.4,5 Review the
patient's drug history, both current and past, for potentially ototoxic drugs (see Table 1 and Assessment of
Patients with Hearing Loss, Ear Pain and Ear Drainage, Table 2). Reassess the need for any ototoxic drug
found; removal of the offending agent may resolve tinnitus.2 All patients with tinnitus lasting >24 hours
should be assessed by an appropriate healthcare practitioner. The severity of tinnitus and the impact on
quality of life should be assessed. The Tinnitus Handicap Inventory (THI) and the Tinnitus Reaction
Questionnaire (TRQ) are two commonly used instruments. See Resource Tips for patient resources.
a,4,5
Table 1: Drugs Reported to Cause Tinnitus
almotriptan doxycycline nortriptyline
amiloride/hydrochlorothiazide eletriptan NSAIDs
aminoglycosides enalapril quinine
amitriptyline frovatriptan risedronate
ASA gabapentin sulfamethoxazole/trimethoprim
atorvastatin galantamine sulfasalazine
buprenorphine imipramine timolol
bupropion irbesartan trazodone
chlorpheniramine linezolid trimipramine
ciprofloxacin loop diuretics valsartan
citalopram mefloquine varenicline
clomipramine norfloxacin venlafaxine
a List is not comprehensive. See Suggested Readings.
Avoid loud noises. Use noise protectors if loud noise cannot be avoided.
Avoid caffeinated beverages and stimulants and stop smoking (significant reduction in tinnitus may be
noted with caffeine and nicotine avoidance).
Use masking techniques or devices (an external noise is used to cover the tinnitus).2
Use hearing aids and cochlear implants in patients with hearing loss.2
Try stress management and biofeedback.
Try tinnitus retraining therapy (multidisciplinary program to habituate patients to the sounds of
tinnitus) combined with cognitive behavior therapy.2,6
Acupuncture has not been shown to be of benefit.2
Many drugs have been studied in the management of tinnitus, including alprazolam, baclofen, gabapentin,
SSRIs, tricyclic antidepressants, zinc and others, and none have been shown to be effective.7,8,9 Ginkgo
biloba has been studied in the management of tinnitus and is commonly used;10,11 however, evidence of
efficacy is lacking.12,13 Adverse effects of ginkgo biloba include mild GI complaints, headache, dizziness,
palpitations and allergic skin reactions. It is also associated with bleeding and seizures. The risk of bleeding
may increase when ginkgo biloba is combined with warfarin or antiplatelet drugs. Advise patients to avoid
this combination.
A number of other natural health products (e.g., bupleurum, feverfew, cordyceps, glossy privet, goldenseal,
ground ivy, lycium, melatonin, poria mushroom), vitamin A and zinc are also purported to be useful for
tinnitus, but no evidence is available to confirm or refute any potential benefit.12
For treatment of tinnitus and other aspects of Meniere's disease, see Vertigo and Dizziness.
Most trials indicate that drugs will have little benefit. If a drug trial is elected despite this, determine a
stopping time with the patient if there is no improvement in the tinnitus. There is no evidence to guide how
long the drug should be tried; clinical trials ran from 6–14 weeks.9,13
Advice for the Patient

Advise patients on:
Nonpharmacologic therapy
Realistic expectations of drug therapy
Possible side effects and their management
Resource Tips
American Speech-Language-Hearing Association. Tinnitus. Available from
www.asha.org/public/hearing/Tinnitus/.
Canadian Academy of Audiology. Tinnitus. Available from canadianaudiology.ca/for-the-public/tinnitus.
National Institute on Deafness and Other Communication Disorders. Tinnitus. Available from
www.nidcd.nih.gov/health/hearing/pages/tinnitus.aspx.
Suggested Readings
Cianfrone G, Pentangelo D, Cianfrone F et al. Pharmacological drugs inducing ototoxicity, vestibular
symptoms and tinnitus: a reasoned and updated guide. Eur Rev Med Pharmacol Sci 2011;15:601-36.
Lockwood AH. Tinnitus. Neurol Clin 2005;23:893-900.
Seligmann H, Podoshin L, Ben-David J et al. Drug-induced tinnitus and other hearing disorders. Drug Saf
1996;14:198-212.
Tunkel DE, Bauer CA, Sun GH et al. Clinical practice guideline: tinnitus. Otolaryngol Head Neck Surg
2014;151:S1-S40.
References
1. Lockwood AH. Tinnitus. Neurol Clin 2005;23:893-900.

2. Lockwood AH, Salvi RJ, Burkard RF. Tinnitus. N Engl J Med 2002;347:904-10.
3. Langguth B, Elgoyhen A. Current pharmacological treatments for tinnitus. Expert Opin Pharmacother
2012;13;2495-509.
4. Cianfrone G, Pentangelo D, Cianfrone F et al. Pharmacological drugs inducing ototoxicity, vestibular
5. Miell M. Can tricyclic antidepressants cause tinnitus? Available from: www.evidence.nhs.uk.
6. Cima RF, Maes IH, Joore MA et al. Specialised treatment based on cognitive behaviour therapy
versus usual care for tinnitus: a randomised controlled trial. Lancet 2012;379:1951-9.
7. Tunkel DE, Bauer CA, Sun GH et al. Clinical practice guideline: tinnitus.Otolaryngol Head Neck Surg
2014;151:S1-S40.
8. Pichora-Fuller MK, Santaguida P, Hammill A et al. Evaluation and treatment of tinnitus: comparative
effectiveness. AHRQ Comparative Effectiveness Reviews 2013. Report No.:13-EHC110-EF.
9. Baldo P, Doree C, Molin P et al. Antidepressants for patients with tinnitus. Cochrane Database Syst
Rev 2012;9:CD003853.
10. Holgers KM, Axelsson A, Pringle I. Ginkgo biloba extract for the treatment of tinnitus. Audiology
1994;33:85-92.
11. Drew S, Davies E. Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled
trial. BMJ 2001;322:73.
12. Natural Medicines Comprehensive Database. Jellin JM, ed. Stockton: Therapeutic Research Faculty.
Available from: naturaldatabase.therapeuticresearch.com. Keyword search: tinnitus. Accessed
February 2013. Subscription required.
13. Hilton M, Stuart E. Ginkgo biloba for tinnitus. Cochrane Database Syst Rev 2004;2:CD003852.

Tinnitus
Tinnitus—What You Need to Know
What is tinnitus?
Tinnitus is the sensation of hearing an abnormal sound in the ears. It may be a ringing, clicking, buzzing, hissing or whistling
sound.
What causes tinnitus?
Tinnitus may be caused by a number of things, including medications and exposure to loud noises. If you take medications,
check with your pharmacist or other health-care professional to see if those medications may be connected to the problem.
Use ear protection if you must be exposed to loud noises.
When should you see a health-care provider?
See a health-care provider if your tinnitus lasts longer than 24 hours.
What is the treatment for tinnitus?
You may be able to manage your tinnitus by avoiding smoking, caffeine and stimulants.
Ask your doctor, pharmacist or audiologist for information about these methods:
using noise to mask tinnitus
using a hearing aid or cochlear implants
stress management or biofeedback
tinnitus retraining therapy
If your health-care provider recommends medication, be sure to ask about possible side effects.
Do not take ginkgo biloba for tinnitus if you are on warfarin or drugs that affect blood clotting (such as ASA or
clopidogrel).
Vertigo and Dizziness

Pathophysiology
Dizziness refers to a variety of sensations such as lightheadedness, fainting, spinning and giddiness.1 Vertigo is one type of dizziness
defined as a sensation of motion where there is none, or an exaggerated sense of motion in response to a given bodily movement.2 It
is the cardinal symptom of vestibular disease resulting from lesions or disturbances in the inner ear, eighth cranial nerve or vestibular
nuclei and their pathways in the brain stem and cerebellum. Vertigo is usually accompanied by varying degrees of nausea and
vomiting as well as pallor and perspiration. It may be acute, chronic or recurrent. Specific conditions that produce vertigo are listed in
Table 1.
Dizziness has a number of causes unrelated to ear conditions, including cardiovascular conditions (e.g., arrhythmias, hypertension),
metabolic or endocrine conditions (e.g., anemia, diabetes), psychiatric conditions, and neurologic conditions (e.g., migraine, head
injury).3
Table 1: Specific Conditions that Produce Vertigo
Type Description Treatmenta
Benign paroxysmal positional Most common type of vertigo (20–42% of Physical manipulation of the head (e.g.,
vertigo (BPPV) all cases).4,5 Epley manoeuvre)5,7,8 much more useful
Probable causes such as viral neuritis (see than drug therapy.4 Epley manoeuvre is a
Vestibular neuritis), surgery, infection, specific sequence of head position
vasculitis and trauma, identified in changes, performed by an appropriately
approximately 50% of cases.6 trained healthcare practitioner, that moves
particles into the posterior semicircular
Presence of debris or small crystals of
canal toward the utricle.7
calcium carbonate (canaliths) in
semicircular canals.4 The Epley manoeuvre has been found to be
more effective than several other
Recurrent bouts of vertigo (brief) resulting
repositioning manoeuvres.9
from changes in head position.6
Routine use of antihistamines and
Hearing loss and tinnitus not usually benzodiazepines not recommended.
present. Vestibular suppressants (Table 3) may be
Symptoms may disappear in a few weeks used for short-term management of severe
but may recur. nausea and vomiting.4,5
Vestibular rehabilitation (physical therapy
program to improve balance, eye-hand
coordination and habituate the patient to
feelings of dizziness) may be offered as
initial or adjunctive therapy.5
Type Description Treatmenta
Meniere's disease Second most common cause of vertigo of Vestibular suppressants (Table 3) with or
otologic origin.4 without antiemetics to treat acute attacks.4
Associated with distention of the Prophylaxis
endolymphatic compartment of the inner Dietary salt restriction (1–2 g/day),
ear.
avoidance of caffeine and smoking.4
Fluctuating hearing, roaring tinnitus, aural
Diuretics, e.g.,
fullness and vertigo.6 hydrochlorothiazide/triamterene
Vertigo has acute onset and persists from (avoid loop diuretics) often
30 min to several hours. recommended but little evidence for
benefit.10
Betahistine is commonly used but has
been shown to be no more effective
than placebo.11,12
Avoid vestibular suppressants for
prophylaxis as they may impair
vestibular compensation.4
Conflicting results have been reported
for positive pressure therapy (Meniett
device).13,14 Minor surgery is required
to place ventilation tubes in the
tympanic membrane.
Vestibular neuritis Self-limiting, preceded by a nonspecific viral Reassurance and explanation; prognosis is
infection.4,6 excellent.
Due to viral infection of the vestibular Avoid movement as this exacerbates
symptoms and use vestibular
portion of the eighth cranial nerve.4
suppressants and antiemetics for 2–3
Sudden onset vertigo, nausea, ataxia and days after which symptoms have usually
nystagmus.4,6 significantly decreased.4
Generally no hearing impairment; referred to Use as few medications as possible and
as labyrinthitis if hearing impairment encourage as much activity as tolerated so
present.4 compensation is not delayed.4,6
Symptoms constant for 2–3 days.4 Methylprednisolone may have a role in
vestibular recovery.15
BPPV may occur in up to 15% of patients
with vestibular neuritis.
Central vertigo Less than 5% of cases.4 Treat underlying cause.4

Often caused by vascular disorders, e.g.,
stroke, transient ischemic attack, migraine.4
a See Table 3 for description of pharmacologic agents.
Drug-induced causes of dizziness are listed in Table 2. Ototoxic drugs may also produce vertigo (see Assessment of Patients with
Hearing Loss, Ear Pain and Ear Drainage, Table 2).
a,16,17
Table 2: Medications That May Cause Dizziness
Dizziness reported in ≥10% of patients
carbamazepine pergolide sertraline

carvedilol pregabalin tenofovir
clomipramine quetiapine tramadol
emtricitabine/tenofovir rivastigmine tretinoin
indinavir
Dizziness reported in 1–10% of patients
acebutolol infliximab quinapril

almotriptan leflunomide rabeprazole
alprazolam letrozole ritonavir
aripiprazole levetiracetam rizatriptan
bisoprolol levonorgestrel ropinirole
botulinum toxin A lisinopril rosiglitazone
buprenorphine lorazepam rosuvastatin
bupropion losartan selegiline
cabergoline mefloquine sildenafil
cilazapril metformin sotalol
citalopram methadone stavudine
dantrolene metoprolol sulindac
desipramine mirtazapine sumatriptan
diuretics naltrexone tacrolimus
donepezil olanzapine tamsulosin
doxazosin olmesartan telmisartan
eletriptan oseltamivir terazosin
emtricitabine oxcarbazepine topiramate
enfuvirtide parathyroid hormone trimipramine
escitalopram paroxetine vardenafil
famotidine perindopril venlafaxine
fluconazole pindolol verapamil
fluoxetine pioglitazone voriconazole
fluvoxamine pramipexole zolmitriptan
fosamprenavir
galantamine
a
List is not comprehensive. See Suggested Readings.
Goals of Therapy
Reduce or eliminate symptoms of vertigo4
Reduce or eliminate nausea and anxiety4
Avoid compromising the process of vestibular compensation (allowing the brain to find a new sensory equilibrium despite the
vestibular lesion) by appropriate use of medications4
Patient Assessment
Always seek potential drug-induced causes of vertigo and dizziness. Medication was reported to be the cause of vertigo/dizziness in
0.8% of patients under age 45 and 2.5% of patients over age 45.18 All patients with vertigo should be assessed by an appropriate
healthcare practitioner. If the vertigo is accompanied by numbness, tingling or weakness in any part of the body, visual disturbances,
confusion or difficulty speaking, this is an emergency. Call 911 as the patient may be experiencing a transient ischemic attack or
stroke.
Nonpharmacologic therapy depends on the cause of the vertigo; see Table 1.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Gastrointestinal
Products: Antiemetics.
Drug therapy for vertigo is symptomatic; in the majority of cases the mechanism of the vertigo is unknown and specific therapy can
therefore not be determined. Unless a specific cause of vertigo is known (e.g., Meniere's disease), the choice of pharmacologic agent
for treatment depends on the adverse effect profile of the drug, presence of contraindications and cost. Most drugs used in vertigo
down-regulate vestibular excitability (vestibular suppressants).4 Table 3 describes drugs used to treat vertigo. Many drugs have been
used for vertigo, including benzodiazepines,4 and flunarizine.4,11,19 Few drugs have been properly evaluated for the treatment of
vertigo. Benzodiazepines in particular have significant disadvantages and little evidence of benefit. They should be avoided unless
use is warranted by comorbidities such as anxiety.
Betahistine was studied in patients with Meniere’s disease. No difference was found between placebo and either dose of betahistine
(48 mg daily or 144 mg daily) in terms of frequency or severity of symptoms.12 This confirms the findings of a previous Cochrane
review that questioned the usefulness of betahistine in patients with Meniere’s disease.20
Although these drugs may reduce vertigo, they also reduce vestibular function in the normal ear, which is a disadvantage. Vestibular
suppressants reduce or slow down vestibular compensation and prevent the CNS from receiving the necessary feedback to facilitate
compensation.4 For this reason, vestibular suppressants are not intended for long-term use. In most cases the duration of treatment
should be a week or less.
For seniors in particular, reassessment of effectiveness of medications that may cause dizziness or reduce CNS feedback is
important. When conducting medication assessments, consider the ongoing need for medications that can affect balance.21,22
Vertigo is often self-limiting. Evaluate the need for continued use of daily medication, at least initially. Determine the severity, duration
and frequency of the vertigo. Monitor the patient for relief of vertigo and associated symptoms such as nausea, vomiting and anxiety.
If no improvement of vertigo is noted, discontinue drug therapy. Monitor patients for adverse effects such as drowsiness and
anticholinergic effects.

Advise patients who receive drug therapy regarding:
Expected duration of treatment

Management of side effects (Table 3)
Instructions not to combine drug therapy with alcohol.
Drug Table
Table 3: Drug Therapy for Vertigo
Class Drug Dosage Adverse Drug Comments Costa
Antiemetics promethazine 25 mg Q6– Drowsiness, Metoclopramide: Avoid $

Histantil 8H po for anticholinergic Increased risk of combining with
nausea effects (dry extrapyramidal CNS
mouth, symptoms. depressants.
mydriasis, Additive Contraindicated
blurred vision, sedation with in angle closure
constipation, alcohol or other glaucoma,
urinary sedating prostatic
retention, medications. hyperplasia and
confusion). urinary
Extrapyramidal May increase retention.
reactions. absorption of
digoxin.
Antivertigo Agents betahistine 24–48 mg Vomiting, GI Antihistamines Warnings about $

Serc, generics divided in pain, may antagonize use in patients
2–3 doses abdominal effects of with ulcer or
daily po distention and betahistine. hyperacidity
bloating can Monitor patients may be
be reduced by using beta2- unfounded.
taking with a Based on one
agonists.
meal or by small study
Betahistine may
reducing the conducted in
counteract
dose. healthy
clinical effect of
Drowsiness, individuals, no
bronchodilators.
confusion. increase in
MAOIs may gastric acid
inhibit
was found.23
metabolism.
Dosage Research has
reduction may be shown no
required. benefit in
Meniere's
disease.12
Class Drug Dosage Adverse Drug Comments Costa
Calcium Channel Blockers flunarizine Initial: 5 mg Weight gain, Additive Many patients $$
generics QHS po; extrapyramidal sedation with have side
increase to effects, other CNS effects.
10 mg QHS drowsiness, depressants, Contraindicated
po after 1–2 depression. such as alcohol, in hypotension,
wk benzodiazepines, heart failure
opioids. and arrhythmia.
Avoid in severe
constipation.
Do not use in
depressed
patients or
those with
extrapyramidal
disorders.
Vestibular dimenhydrinate 25–50 mg Drowsiness, Additive Avoid $

Suppressants/Antiemetics Gravol, Q6H po or anticholinergic sedation with combining with
generics 100 mg Q8H effects (dry alcohol or other CNS
pr mouth, sedating depressants.
mydriasis, medications. Contraindicated
blurred vision, May increase in angle closure
constipation, absorption of glaucoma,
urinary digoxin. prostatic
retention, hyperplasia and
confusion). urinary
retention.
Vestibular scopolamine Transdermal Drowsiness, Additive Avoid $$$/patch

Suppressants/Antiemetics Transderm-V patch (1.5 anticholinergic sedation with combining with
mg delivers effects (dry alcohol or other CNS
1 mg over 3 mouth, sedating depressants.
days) 1 mydriasis, medications. Contraindicated
patch Q72H blurred vision, in angle closure
constipation, glaucoma,
urinary prostatic
retention, hyperplasia and
confusion). urinary
Local retention.
reactions,
allergies.
a
Legend: $ <$1 $$ $1–2 $$$ $2–5
Suggested Readings
Ponka D, Kirlew M. Top 10 differential diagnoses in family medicine: Vertigo and dizziness. Can Fam Physician 2007;53:1959.
Post RE, Dickerson LM. Dizziness: a diagnostic approach. Am Fam Physician 2010;82:361-8, 369.
Sloane PD, Coeytaux RR, Beck RS et al. Dizziness: state of the science. Ann Intern Med 2001;134:823-32.
Swartz R, Longwell P. Treatment of vertigo. Am Fam Physician 2005;71:1115-22.
References
1. Walker MF, Daroff RB. Dizziness and vertigo. In: Fauci AS et al., eds. Harrison's principles of internal medicine. 19th ed. New
York: McGraw-Hill; 2015. Available from: accessmedicine.mhmedical.com/content.aspx?bookid=1130&Sectionid=79724668.
Accessed August 30, 2015. Subscription required.
2. Swartz R, Longwell P. Treatment of vertigo. Am Fam Physician 2005;71:1115-22.
3. Kerber KA. Vertigo and dizziness in the emergency department. Emerg Med Clin North Am 2009;27:39-50.
4. Hain TC, Uddin M. Pharmacologic treatment of vertigo. CNS Drugs 2003;17:85-100.
Assessment of Patients with Eye Conditions
Anne M. Friesen, BSc(Pharm), MSc

Date of Revision: July 2015 blunt trauma- not hurt recently
Algorithms
Figure 1: Assessment of Patients with Eye Conditions
a See Parasitic Skin Infections: Lice and Scabies.
Conjunctivitis

Pathophysiology
The conjunctiva is a thin, translucent, relatively elastic tissue layer that lines the inside of the eyelids
(palpebral portion) and the anterior aspect of the globe (bulbar portion); see Eyelid Conditions: Hordeolum,
Chalazion and Blepharitis, Figure 1. As the outermost layer of the exterior surface of the globe, the
conjunctiva is exposed to many microorganisms and other environmental factors. The combined action of
the tears and eyelids protect the conjunctiva by trapping and diluting debris and organisms, then flushing
the tears into the nasolacrimal duct.1,2
Common causes of conjunctivitis are listed in Table 1.

2,3,4,5
Table 1: Causes of Conjunctivitis
Bacterial Neonates: Chlamydia trachomatis, Staphylococcus aureus,
Haemophilus influenzae, Streptococcus pneumoniae, Neisseria
gonorrhoeae, Neisseria meningitidis
Children: H. influenzae, S. pneumoniae, S. aureus
Adults: S. aureus, coagulase-negative Staphylococcus organisms,

H. influenzae, S. pneumoniae, N. gonorrhoeae, N. meningitidis
Viral Adenovirus
Herpes simplex virus
Immunologic Immediate hypersensitivity reactions: hay fever, vernal

keratoconjunctivitis, atopic keratoconjunctivitis, giant papillary
conjunctivitis
Autoimmune disease: keratoconjunctivitis sicca with Sjögren's

syndrome, ocular cicatricial pemphigoid
Delayed hypersensitivity reactions
Chemical or irritative Iatrogenic: miotics, idoxuridine, preservatives, contact lens

solutions
Occupational: acids, alkalies, smoke, wind, UV light
Irritative: superior limbic keratoconjunctivitis
Associated with Ocular rosacea

dermatologic condition Psoriasis
Stevens-Johnson syndrome (erythema multiforme major)
Associated with systemic Thyroid disease

disease Kawasaki disease
Lacrimal system infections Canaliculitis
Dacryocystitis
Conjunctivitis is a general term that refers to any inflammatory condition of the membrane that lines the
inside of the eyelids and covers the exposed surface of the sclera. The inflammation can be hyperacute,
acute or chronic in presentation and may be caused by infection or many other factors (see Table 1).
Conjunctivitis is the most common cause of red eye worldwide.2,3 This chapter addresses bacterial
(hyperacute, acute and chronic), viral and allergic conjunctivitis.
Goals of Therapy
Relieve symptoms
Prevent complications (preserve eyesight)
Prevent recurrence
Cure or control infection, where present
Prevent transmission of infection to others
Patient Assessment
An algorithm for the assessment of eye conditions is presented in Assessment of Patients with Eye
Conditions.
Typically, patients present with some degree of redness in the conjunctiva, as well as some type of
discharge. Other descriptions of symptoms include a scratching or burning sensation, a foreign body
sensation, a feeling of fullness around the eyes, itching and mild photophobia. Often the eyes are crusty or
sticky after sleeping, particularly with bacterial conjunctivitis.
Signs and symptoms of the most common types of conjunctivitis are listed in Table 2.
Table 2: Signs and Symptoms of Conjunctivitis

Clinical Findings Viral Bacterial Allergic
Itching Minimal Minimal Severe
Redness Generalized Generalized Generalized
Discharge Profuse, serous Moderate, mucopurulent Moderate, serous or

or purulent mucoid
Acute Bacterial Conjunctivitis
Introduction
Approximately 60% of suspected and documented cases of bacterial conjunctivitis are self-limiting and
resolve without treatment in 1–2 weeks.6 However, antibiotic treatment can reduce the duration of the
disease and may decrease the risk of more serious corneal complications, recurrences, and person-to-
person spread.2,3,5,7,8,9,10 The most common causative organism is S. aureus, but S. pneumoniae and H.
influenzae are also common, especially in children.1,5,11,12,13
The patient, family and other care providers should be careful to prevent contamination by avoiding
direct hand-to-eye contact, and should employ proper hand-washing techniques to avoid transmitting
the infection (see Eyelid Conditions: Hordeolum, Chalazion and Blepharitis, Infections of the Eyes or
Eyelids—What you Need to Know).
If eyelids are stuck together in the morning, soak with a warm compress and open carefully.
The conjunctival sac can be irrigated with sterile saline or a commercial eye wash product as
necessary to remove conjunctival secretions.
Because of an increased risk of developing serious infections, advise contact lens wearers with
conjunctivitis to stop using their lenses and seek medical advice.6
Patients who use eye drops, e.g., for glaucoma or dry eye, should replace the eye drop bottles in case
the bottles have been inadvertently contaminated.
Ailments—Ophthalmic Products: Anti-infectives.
For mild cases of bacterial conjunctivitis in adults, polymyxin B/gramicidin eye drops can be instilled in the
affected eye(s) 4–6 times a day for 7–10 days. Generally, continue treatment for 2 days after symptoms
have resolved.1,2,3,5,7,12,14,15
Polymyxin B-based combinations are not reliably bactericidal.15 If there is no improvement within 48 hours
of starting treatment, refer the patient to a physician or eye care practitioner; all children with conjunctivitis
should be referred to a physician.
When the infection is moderate to severe, or if polymyxin-based products have been ineffective, the use of
standard empiric treatment with broad spectrum antibacterial drops is warranted (e.g.,
trimethoprim/polymyxin B, ophthalmic ointments containing erythromycin or bacitracin).5,7,12,14 Adults
and adolescents generally prefer ophthalmic drops. Ointments may be better tolerated by young children,
who may not be bothered by ointment-induced blurred vision and may find drop administration irritating.
Tobramycin provides good gram-negative coverage and relatively poor gram-positive coverage with
systemic use but is sufficiently effective in the topical treatment of conjunctivitis. Toxicity to the corneal
epithelium can occur, especially with prolonged use. Reserve fluoroquinolone antibiotics (ciprofloxacin,
gatifloxacin, moxifloxacin, ofloxacin) for serious infections such as bacterial keratitis.1,2,3,5,7,12,14
For more information on antibacterial therapy for conjunctivitis, consult the Compendium of Therapeutic
Choices: Red Eye.
.....
Hyperacute Bacterial Conjunctivitis
Introduction
This infection is most commonly seen in neonates or sexually active young people (15–24 years
old).2,3,5,7,11,14 It is a severe, sight-threatening ocular infection caused by N. gonorrhoeae or N. meningitidis.
It is characterized by a copious, yellow-green purulent discharge, redness, irritation and tenderness to
palpation. Symptoms are rapidly progressive, leading to severe corneal damage, perforation and loss of
vision if there is any delay in treatment. In adults, the organism is usually transmitted from the genitalia to
the hands and then to the eyes. In infants, transmission of the organism occurs during vaginal delivery, and
they typically develop bilateral discharge 3–5 days after birth. As a preventive measure, ophthalmic
antibiotic ointments have been routinely applied to infants immediately after delivery. However, the Canadian
Pediatric Society currently recommends abolishing the mandatory application of antibiotic ophthalmic
ointment to newborns.16 Instead, they recommend screening all pregnant women for gonorrhea and
chlamydia, and subsequently treating infants with effective antibiotics if the mother had untreated infection
at time of delivery.
Immediate medical assessment is required. After treatment has been initiated, the same adjunctive
nonpharmacologic measures as used for acute bacterial conjunctivitis can be implemented.2,5,14
Medical assessment is imperative.
Treatment consists of immediate Gram staining of specimens, followed by systemic and ophthalmic
antibacterials and saline irrigation. In adults, ceftriaxone 1–2 g im is the therapy of choice.
For more information on therapy for hyperacute bacterial conjunctivitis, consult the Compendium of
Therapeutic Choices: Red Eye.
.....
Chronic Bacterial Conjunctivitis
Introduction
Chronic bacterial conjunctivitis is defined as a condition that lasts 4 weeks or longer. It is often associated
with blepharitis, and is sometimes found in conjunction with facial seborrhea, acne rosacea, nasolacrimal
duct obstruction or chronic dacryocystitis. S. aureus and Moraxella lacunata are most commonly involved,
the latter occurring in clusters in women who share contaminated makeup.4,14
Treatment is similar to the treatment of blepharitis. See Eyelid Conditions: Hordeolum, Chalazion and
Blepharitis. Eyelid hygiene and warm compresses are important as a daily routine. Contaminated facial care
products and makeup should be discarded.2,3,14
Chronic bacterial conjunctivitis has a protracted course with periods of exacerbation and appropriate
treatment should be carefully managed by an appropriate healthcare practitioner.
Topical antibacterials are used during periods of exacerbation. Patients whose chronic conjunctivitis is
associated with meibomian gland dysfunction or severe acne rosacea may benefit from oral agents such as
doxycycline or erythromycin. Topical metronidazole therapy for acne rosacea may also ameliorate
associated conjunctivitis.
For further discussion of antibacterial prescription therapy for chronic conjunctivitis, consult the
Compendium of Therapeutic Choices: Red Eye.
.....
Viral Conjunctivitis
Introduction
Patients with viral conjunctivitis usually present with an acutely red eye, watery discharge, conjunctival
swelling, foreign body sensation and mild photophobia. There may be tenderness around the preauricular
node. Occasionally, patients may have subconjunctival hemorrhage.3,17 Both eyes may be affected at the
same time, or the second eye may become infected a few days after the first. If this happens, the infection is
usually more severe in the first eye.
The most common causative organism is adenovirus. Viral infections are highly contagious and can be
spread through respiratory tract-to-eye, finger-to-eye, or instrument-to-eye (physician's office) contact, and
via contaminated swimming pools. Some patients have an associated respiratory tract infection.2,3,11,14,17
The incubation period ranges from 2–14 days and the infection can last from 2–4 weeks.11 It is contagious
for 2 weeks after the second eye becomes involved.5
Herpes simplex virus (HSV) and herpes zoster can also cause viral conjunctivitis. The risk of progressive
keratitis is higher with these types of infection.
All patients with suspected viral conjunctivitis require medical assessment to determine the cause.
Treatment of adenovirus conjunctivitis is supportive. Cold compresses may increase patient comfort.18
Instruct patients to avoid direct contact with other persons for at least 14 days after the onset of symptoms
or until the eyes are no longer red and weeping.17 Children should be kept out of school until there is no
ocular discharge (approximately 1 week).3,19
Ocular lubricants may be useful in improving patient comfort.18 Ophthalmic decongestants or
antihistamines may help with severe itching, but are generally not indicated.
Antiviral agents are usually not indicated in adenovirus infection, although cidofovir (available only through
Health Canada’s Special Access Programme) has been used successfully.18 Corticosteroid eye drops may
prolong the course of the disease by allowing viral proliferation and should only be used under the direction
of an ophthalmologist.18
Treatment of HSV usually consists of topical (trifluridine) or oral antiviral agents (acyclovir, famciclovir,
valacyclovir), while only oral agents are used for herpes zoster infection.2,3,14,18
For further discussion of pharmacologic therapy for HSV or herpes zoster, consult the Compendium of
.....
Allergic Conjunctivitis
Introduction
Allergic conjunctivitis encompasses a group of ocular surface diseases that vary in severity, but are typically
associated with Type I hypersensitivity reactions.20 Seasonal allergic conjunctivitis (SAC) and perennial
allergic conjunctivitis (PAC) comprise approximately 95% of allergic conjunctivitis cases. Vernal
keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC) and giant papillary conjunctivitis (GPC) are rare
but more serious conditions which require assessment and management by an ophthalmologist.
In SAC, also known as hay fever, patients experience ocular itching, tearing, redness and mild eyelid
swelling.2,3,4 Although ragweed is the most common airborne cause of allergic rhinitis, grass pollen is
considered the most common cause of ocular symptoms.21,22 Dry eye can also be a factor in SAC—reduced
tear volume leads to decreased capacity to dilute and wash away allergens.
PAC exhibits the same symptoms as SAC, but reactions are triggered by environmental allergens commonly
found in the home (e.g., dust mites, mold spores, animal dander). Patients suffer throughout the year, but
may have seasonal exacerbations in addition to chronic symptoms.23
Although other ocular conditions (e.g., blepharitis, dry eye) present similarly, the hallmark symptom of SAC
is ocular itching, while patients with PAC have red eyes as their primary symptom.20 For further information
on allergic conjunctivitis in relation to allergic rhinitis, see Allergic Rhinitis.
Allergen avoidance is an important first step in the treatment of allergic conjunctivitis.24,25 In SAC, minimize
exposure to grassy fields, trees and flowers and keep windows closed to prevent pollens from entering the
home. Wash hands after being outdoors and avoid touching/rubbing the eyes while outdoors. Wraparound
eyeglasses are an effective means to protect the eyes from pollens and reduce symptoms of SAC.26
In PAC, allergen avoidance may be more problematic as it could involve the family pet.23 However, dust mite
control measures, proper ventilation of home and office environments, air filtration systems, and awareness
of allergen prevalence (pollen and mold counts) can all help to ease symptoms. Washing the hair prior to
going to bed can also help reduce allergen exposure.
Cold compresses over the eyes offer considerable symptom relief, especially ocular pruritus.25
Ailments—Ophthalmic Products: Anti-allergy Agents, Antihistamines and Decongestants; Ocular Lubricants.
Ocular lubricants help to wash out allergens and may act as a barrier to pollens.25 Benzalkonium chloride (a
preservative in some lubricants) may irritate eyes, especially if used ≥4 times per day; avoid when possible.
Saline or commercial eyewashes can help wash out allergens and reduce eyelid swelling, chemosis
(conjunctival edema) and hyperemia (redness due to increased blood flow). These are both first-line
treatment options; refrigeration may improve their soothing effect.
Ophthalmic decongestants (e.g., naphazoline, oxymetazoline, phenylephrine, tetrahydrozoline) decrease

eye redness and eyelid edema through vasoconstriction. They may cause rebound ocular congestion with
prolonged use (time frame not clearly defined, but probably with use >10 days).27 If rebound congestion
occurs, it is likely to be mild and harmless.27 Ophthalmic decongestants are second-line treatment options
for mild-moderate SAC; they are not indicated for prolonged use in PAC. Because they are vasoconstrictors,
they are contraindicated in patients with narrow angle (angle-closure) glaucoma.
Oral H1 antihistamines may relieve itching associated with SAC, but do not decrease redness.24 Ophthalmic
antihistamines are available in combination with decongestants (e.g., pheniramine in combination with
decongestants listed above), and are preferred over systemic antihistamines because they act faster and
are less drying.25,28 Emedastine is a topical histamine H1 antagonist with a rapid onset of action. It is more
effective than antihistamine/vasoconstrictor combinations or oral antihistamines in relieving itchy, watery
eyes;27 however it is not available as a self-care option.
Mast cell stabilizers prevent degranulation of mast cells and are useful in both SAC and PAC as they treat
the late phase of the allergic response.20 Regular use during allergy season will prevent redness, itching and
eyelid edema. Mast cell stabilizers may take up to 10 days for maximum effect; they must be started before
allergy season to prevent symptoms. Nedocromil, lodoxamide and sodium cromoglycate are mast cell
stabilizing agents that alleviate the signs and symptoms of mild to moderate allergic
conjunctivitis.2,22,24,28,29
Agents that have both antihistaminic and mast cell stabilizing properties (e.g., olopatadine, ketotifen) will
relieve itching quickly while providing long-term activity against ocular irritation by allergens.20
Nonsteroidal anti-inflammatory eye drops such as ketorolac can decrease the amount of ocular itching and
conjunctival redness in allergic conjunctivitis.2,22,24 These agents may cause stinging upon instillation; limit
to short-term use to avoid serious corneal effects, such as keratitis, ulceration, or even corneal perforation.
Patients at increased risk of corneal effects include those with dry eye syndrome and those recovering from
recent surgery.
Once the immediate problem of allergic symptoms is addressed, question the patient about possible dry eye
symptoms. Patients with moderate to severe allergic conjunctivitis, or those who do not respond to self-care
measures within 72 hours, require further medical assessment. Severe cases of SAC may require the use of
topical corticosteroids or other immunomodulatory agents under the care of an ophthalmologist.2,22,24
For further discussion of pharmacologic therapy for allergic conjunctivitis, consult the Compendium of
Table 3 provides a monitoring plan that should be individualized for the patient and the condition.
1,2,3,17
Table 3: Monitoring of Therapy for Conjunctivitis
Goals/Endpoint of
Eye Condition Monitoring Therapy Actions
Bacterial Patient: Daily Resolution of Adults: Requires consultation for

conjunctivitis5,14 Healthcare infection. further therapy if worsening or no
practitioner: A decrease in signs improvement within 48 h.
Within 2 days and symptoms Children: Requires consultation for
of initiating should occur within further therapy. Do not recommend
drug therapy 48 h. self-treatment.
Chronic bacterial Patient: Daily Control of infection. Encourage lid hygiene regimen
conjunctivitis5,14 Healthcare Reduce the risk of (see Eyelid Conditions: Hordeolum,
practitioner: long-term Chalazion and Blepharitis). Remind
Each visit complications. patient to cleanse only the margin
of the eyelid and not to scratch the
eyeball or conjunctiva. Requires
consultation for further therapy if
recurrence or acute exacerbation
occurs.
Viral Patient/family: Ease symptoms Requires medical assessment to

conjunctivitis Daily while infection rule out other viral causes.
(adenovirus)14 Healthcare resolves. If decongestant or lubricant drops
practitioner: Prevent transmission cause irritation, discontinue use or
Within 1 wk of to others. suggest a preservative-free
initiating product.
treatment
Goals/Endpoint of
Eye Condition Monitoring Therapy Actions
Seasonal allergic Patient: Daily Ease patient If decongestant or lubricant drops

conjunctivitis21,30 Healthcare discomfort. cause irritation, discontinue use or
practitioner: Stop suggest a preservative-free
Within 3 days allergic/inflammatory product.
of initiating process. Requires consultation for further
drug therapy Prevent recurrence in therapy if no improvement within 3
future seasons. days, or if symptoms persist
despite treatment.
Requires consultation for further
therapy if symptoms are severe.
.....
Suggested Readings
American Academy of Ophthalmology. Conjunctivitis PPP-2013. Available from: www.aao.org/preferred-
practice-pattern/conjunctivitis-ppp--2013.
Merck manual: professional version. Overview of conjunctival and scleral disorders. Available from:
www.merckmanuals.com/professional/eye-disorders/conjunctival-and-scleral-disorders/overview-of-
conjunctival-and-scleral-disorders.
Narayana S, McGee S. Bedside diagnosis of the 'red eye': a systematic review. Am J Med 2015;128:1220-4.
Sheikh A, Hurwitz B, van Schayck CP et al. Antibiotics versus placebo for acute bacterial conjunctivitis.
Cochrane Database Syst Rev 2012;9:CD001211.
References
1. Baum J. Infections of the eye. Clin Infect Dis 1995;21:479-86.

2. Garcia-Ferrer FJ, Schwab IR, Shetlar DJ. Conjunctiva. In: Riordan-Eva P, Whitcher J, eds. Vaughan &
Asbury's general ophthalmology. 17th ed. New York: Lange Medical Books/McGraw-Hill Medical;
2008.
3. Morrow GL, Abbott RL. Conjunctivitis. Am Fam Physician 1998;57:735-46.
4. Kanski JJ. Clinical ophthalmology: a systematic approach. 4th ed. Boston: Butterworth-Heinemann;
1999.
5. Tarabishy AB, Jeng BH. Bacterial conjunctivitis: a review for internists. Cleve Clin J Med 2008;75:507-
12.
6. Amir AA, Barney NP. Conjunctivitis: a systematic review of diagnosis and treatment. JAMA
2013;310:1721-9.
7. Hovding G. Acute bacterial conjunctivitis. Acta Ophthalmol 2008;86:5-17.
8. Sheikh A, Hurwitz B, van Schayck CP et al. Antibiotics versus placebo for acute bacterial
conjunctivitis. Cochrane Database Syst Rev 2012;9:CD001211.
9. Hutnik C, Mohammed-Shahi MH. Bacterial conjunctivitis. Clin Ophthalmol 2010;4:1451-7.
10. Epling J. Bacterial conjunctivitis. Clin Evid (Online) 2012;pii:0704.
11. Jackson WB. Differentiating conjunctivitis of diverse origins. Surv Ophthalmol 1993;38:91-104.
12. Weiss A, Brinser JH, Nazar-Stewart V. Acute conjunctivitis in childhood. J Pediatr 1993;122:10-4.
13. Golde KT, Gardiner MF. Bacterial conjunctivitis in children: a current review of pathogens and
treatment. Int Ophthalmol Clin 2011;51:85-92.
14. Thielen TL, Castle SS, Terry JE. Anterior ocular infections: an overview of pathophysiology and
treatment. Ann Pharmacother 2000;34:235-46.
Contact Lens Care
David S. Wing, BSP, MS

Ken Gellatly, OD
Introduction
Contact lenses can correct refractive errors associated with hyperopia (farsightedness), myopia (near-sightedness), astigmatism (related to shape of eye or cornea),
presbyopia (age-related decline in acuity of near objects) and aphakia (reduced near and far vision related to absence of lens). Contact lenses are foreign bodies that
sit on a tear cushion and do not actually make contact with the eye as implied by their name. As tears constantly bathe the cornea and supply oxygen, contact lenses
act as physical barriers, leading to progressive hypoxia and edema. Development of clinical symptoms depends on lens materials, design and fit; the duration of wear
and the adherence to the care regimen.
Contact lenses offer many advantages over eyeglasses:1,2
An entire field of view in focus

Natural appearance
No fogging from temperature changes, perspiration or weather
No annoying reflections and peripheral obstructions.
Types of Contact Lenses

The 2 major types of contact lenses are soft and rigid gas-permeable (RGP). Soft lenses are worn by over 90% of Canadian contact lens users, thus the chapter will
focus on their maintenance and care.3 Table 1 compares some of the important features of RGP and soft lenses.
Rigid Gas-permeable Lenses
RGP lenses, also known as hard lenses, retain the optical qualities and durability of PMMA (polymethyl methacrylate, the original, but now obsolete, hard lens) but
have increased oxygen permeability and comfort.4 RGP lenses have a sufficiently high oxygen permeability to prevent clinically observable corneal edema with
normal wear. Hence, they offer better long-term visual acuity and, in general, result in fewer complications than either PMMA or soft lenses. Although RGP lenses
have replaced the original PMMA lenses as the standard of care for hard lenses, their use is decreasing and accounts for only 10% of contact lenses.5
Soft Lenses
Soft lenses, or hydrogels, are made of a flexible polymeric material, usually hydroxyethyl methacrylate (HEMA), that has a high capacity for water absorption.6,7
Most soft lenses currently available are silicone hydrogels, also made of HEMA, with the addition of silicone. Silicone hydrogels are the new standard in soft contact
lenses and have replaced old (conventional) hydrogels.8 Silicone hydrogels contain a much better polymer with increased oxygen permeability compared with
conventional hydrogels, which has enabled longer wear times, and dramatically decreased incidence of hypoxia and corneal edema.9 Silicone hydrogels also adsorb
less protein;10 when used with nonpreserved care solutions, they may be the safest choice11 although a study found no decrease in the risk of microbial keratitis.12
The main advantage of soft lenses over RGP lenses is increased comfort. This is due to their flexibility (which increases with increasing water content), soft thin
edges and hydrophilic nature. The vast majority of contact lens users wear soft lenses. Unfortunately, these lenses have an open matrix in which tear film
lipoproteins, ophthalmic preparations, environmental pollutants, chemical vapors, oil and dust from fingers, cosmetics and some contact lens solution preservatives
concentrate, all of which can lead to ocular irritation. Soft lens materials also tend to develop lens deposits (accumulation of proteins and lipids), a risk factor for
the development of microbial keratitis, more rapidly than RGP lens materials.
Table 1: Comparative Features of Rigid Gas-permeable and Soft Contact Lenses

Characteristics Soft Lenses RGP Lenses
Composition Silicone hydrogel PMMA/silicone, fluorosilicone acrylate
Water content 29–85% (hydrophilic); silicone hydrogels are ≤2% (hydrophobic)

made of hydrophobic material but have a
hydrophilic surface treatment
Life expectancy of lens 1 day to 1 year 5 years (unless lost earlier)
Solution requirements Only soft lens solutions Only RGP solutions
Visual acuity Good Excellent
Initial cost Similar Similar
Maintenance cost More Less
Gas permeability Less More
Initial comfort Most comfortable Intermediate
Adaptability (days until new lenses feel comfortable) <1 5–10
Long-term comfort Most comfortable Intermediate

Characteristics Soft Lenses RGP Lenses
Daily wear time (hours) >12 >12
Extended wear (days) ≤7 (hydrogels) ≤7

≤30 (silicone hydrogels)
Strength Fragile Strong
Accumulation of deposits from tear film Most susceptible Least susceptible
Effect of humidity Easily affected Minimally affected
Risk of microbial contamination Greatest Slight
Abbreviations: PMMA = polymethyl methacrylate; RGP = rigid gas-permeable
Combination RGP/Soft Lenses
In combination lenses, an RGP centre is fused to a heme skirt to provide the great optics of RGP with the comfort of HEMA. The combination is indicated for
keratoconus and other corneal dystrophies. Soft lens solutions are used with these combination lenses.
Wear Schedules
Lenses are worn according to various replacement schedules: conventional (1 year or more), planned replacement (lenses replaced every 2 weeks, every month or
every 3 months) or daily (brand new soft lenses inserted every day). The vast majority of contact lens users follow a planned replacement schedule; a decreasing
number of people follow a conventional schedule while an increasing number use daily disposables.3,8,13,14
Adherence problems related to conventional schedules (e.g., inadequate cleaning, disinfection and rinsing, reuse of old solutions, poor hygiene, using lenses for a
longer time than recommended), lead to the development of planned replacement programs (PRPs).
Advantages of PRPs include:
More frequent insertion of a new, sterile lens

Lower cost because of reduced need for solutions (multipurpose solutions can replace single-purpose solutions)
Improved vision (from more frequent replacement)
Improved comfort (deposits are reduced, which increases lens wettability and reduces dryness)
Improved adherence (from increased monitoring)
More convenience (multipurpose solutions can be used, in association with increased monitoring)
Fewer complaint-related office visits (reduction in giant papillary conjunctivitis, acute red eye and infective or inflammatory keratitis)
Fewer problems associated with lost lenses (wearer has immediate access to a new set of lenses) or damaged lenses (wearer has no need to keep an old spare
pair of lenses on hand).
In addition to supplied lenses, a disposable system that includes solutions and storage cases that are replaced at regular intervals may decrease the risk of ocular
infections.
Daily disposables are sterile soft lenses that are opened fresh each day, worn for the day, and then disposed of in the evening. These lenses require no regular solutions
for daily care and offer advantages for wearers who may have adherence problems with one of the other wear schedules.15 Reuse of lenses increases the risk of
contamination.16
Extended wear is defined as continuous use of a contact lens for 24 hours or more. The lenses are usually soft; however, RGP lenses are increasingly being used in
extended-wear schedules. Early uncontrolled trials suggested that the rate of serious complications was not excessive and many wearers adopted extended-wear
schedules. However, extended wear of contact lenses was eventually implicated in promoting microbial keratitis.17,18 The most likely causes are increased protein
accumulation, decreased flushing of bacteria during sleep and decreased immunologic activity during sleep. The prevalence of extended wear has decreased, likely
due to increased risk of infection.19
Goals of Contact Lens Care

Optimize vision
Promote lens longevity and comfort
Minimize complications such as eye irritation and infection
Patient Assessment
Use the following questions and answers to identify potential problems and aid in appropriate and timely referral to eye care professionals.
What type of contact lenses are you wearing?
The lens type (RGP or soft) determines the care regimen. Solutions for a specific lens type from the same manufacturer can likely be interchanged. Advise patients
to consult their eye care professional for confirmation.
Do you have any of the following symptoms:
Pain when inserting or wearing the lenses or after wearing them?

Burning that causes excessive tearing?
Inability to keep your eyes open?
Severe or persistent haze, fog or halos while wearing the lenses?
Redness, irritation or itching?
Poor vision?
These symptoms may be due to poor lens fit, damaged lenses, improper handling, microbial conjunctivitis, solution or lens intolerance, ocular or systemic disease
or improper lens care. Painful lid swelling and photophobia may be due to over wear. Advise patients to discontinue lens wear and consult their eye care
professional if any of these symptoms occur.20
How long have you worn lenses?
Most contact lens wearers experience mild discomfort during the first few days while the eyes adapt. Since it may not be obvious at first which problems are
significant, advise wearers to contact their eye care professional.
What medications are you taking?
Advise patients to consult an eye care professional before using any ophthalmic preparation with their lenses in place. Almost any ophthalmic product that is not
specifically designed for use with contact lenses will cause temporary discomfort.
Numerous systemic medications can alter eye dynamics sufficiently to warrant therapeutic intervention. Sedatives (including alcohol), hypnotics, antihistamines
and muscle relaxants can affect the eyelid, producing incomplete blinking or a decreased rate of blinking. Antihistamines, anticholinergics, tricyclic antidepressants
and diuretics can decrease tear volume, leading to significant discomfort. See Table 2 and Table 3.
21,22,23,24,25
Table 2: Interactions between Contact Lenses and Systemic Drugs
Drug Effect on Lenses
Oral contraceptives26 Lens intolerance due to exacerbation of dry eye
Antihistamines27,28 Decrease in blink rate (blinking is required to maintain hydration in soft lens wearers and helps
supply oxygen to the cornea in RGP lens wearers)
Hypnotics
Sedatives
Muscle relaxants Incomplete blinking
Anticholinergics Decreased tear volume (leading to irritation and deposits in soft lens wearers, and corneal drying
Antihistamines in RGP lens wearers)
Tricyclic antidepressants29,30
Isotretinoin31 Itching and decreased wear time in soft lens wearers
ASA32 Ocular irritation and redness in soft lens wearers
Nitrofurantoin Discoloration of soft lenses

Phenazopyridine
Rifampin33,34
Sulfasalazine35
Tetracycline
Abbreviations: RGP = rigid gas-permeable
22,25,36,37
Table 3: Interactions between Soft Contact Lenses and Ophthalmic Products
Note
Ophthalmic Agent Effect on Soft Lenses
Phenylephrine Dark discoloration of lens with repeated use

Tetrahydrozoline
Benzalkonium chloride (preservative) Can concentrate in soft lenses and cause ocular toxicity
Fluorescein38 Can concentrate in soft lenses and cause staining
Rose bengal (diagnostic ophthalmic dyes)
What products do you use for the care of your lenses?
Eye care professionals recommend specific products for lenses. When purchasing these products, patients may need guidance to select or substitute appropriately.
Refer the wearer to an eye care professional if there is any confusion or uncertainty regarding the correct solution to use. See also Prevention of Complications.
Describe how you use your lens care products.
To ensure wearers adhere to prescribed care, ask them to describe their care regimen (Figure 1). Nonadherence is the greatest threat to eye comfort and lens life.
Inadequate cleaning and disinfection cause about 50% of all problems associated with contact lenses.
What measures do you take before reinsertion after the lens has been dropped?
Unfortunately, wearers often pick up and promptly reinsert the lens along with whatever it has collected when removed from the eye. The proper technique is to
reclean RGP lenses with soaking/wetting solution; rinse soft lenses with an appropriate rinsing solution (normal saline or multipurpose solution) before reinserting.
Prevention of Complications
Proper care of contact lenses is crucial in maintaining optimal eye health. The ideal contact lens care system would be economical, easy to use, free of side effects
and would maintain all types of contact lenses in a clean and sterile state. Improved contact lens technology (e.g., daily disposables, improvements in oxygen
permeability, multipurpose solutions) have brought the standard of practice closer to the ideal.39,40 Figure 1 outlines the steps required to maintain soft contact
lenses.
Nonadherence with proper lens care is the greatest threat to eye health and lens life, and affects as many as 50–99% of contact lens wearers.41 Common forms of
nonadherence include inadequate cleaning or rinsing, and economizing by using old solutions and old cases. Solution contamination (e.g., topping up old
contaminated solution containers rather than replacing them), inadequate lens disinfection, manipulation of the lens in the eye and poor hygiene increase the
exposure of the eye to pathogens, that can lead to microbial keratitis and corneal ulcers.42,43,44,45,46,47,48,49 Adherence may be improved by explaining its benefits
along with consequences of nonadherence.50 New methods of improving adherence are required as education alone may be insufficient.51
Products for Contact Lenses
Contact Lens Solutions
For comparative ingredients of lens care products, consult the Compendium of Products for Minor Ailments—Contact Lens Products: Contact Lens Solutions for Soft
and Rigid Gas-Permeable Lenses, Rigid Gas-Permeable Contact Lens Cleaning Systems, Soft Contact Lens Cleaning Chemical Systems, Soft Contact Lens
Hydrogen Peroxide Cleaning Systems.
General Principles
When contact lenses are purchased, the wearer usually receives a contact lens case and a multipurpose solution, with or without various other solutions (e.g.,
rinsing, wetting). Once the sample is finished, wearers tend to replace their solutions with the same brand if the solutions have been well tolerated. If not
tolerated, the eye care professional will recommend a different set of solutions on a trial basis. This trial-and-error scenario is repeated until the eye care
professional considers the effect of the solutions on the corneal epithelium, as viewed by a biomicroscope, is considered acceptable. Unless otherwise
instructed by their eye care professional, advise wearers to always use solutions from a single manufacturer. Each manufacturer formulates all components of
its care regimen to be compatible with each other. The effect of substituting even one solution from a different manufacturer is not predictable, even if it has the
same active ingredients in the same concentration. In addition, all solutions that are recommended by an eye care professional will have been found to be
compatible with the wearer.
Although the majority of contact lens wearers use a multipurpose solution, single-purpose solutions are still discussed for educational purposes.
Multipurpose Solutions
In the past, eye care professionals may have recommended as many as 5 single products to use as part of a contact lens care regimen. To increase
convenience, many products combine 2 or more functions in a single multipurpose solution.52,53 The increase in use of multipurpose solutions has paralleled
the increase in use of silicone hydrogels; accordingly, the majority of contact lens users employ a multipurpose solution for the maintenance of their lenses.54
Although some researchers suggest that cleaning is compromised with the use of multipurpose solutions, clinical evaluations of multipurpose products for both
soft and RGP lenses have shown they improve adherence and exhibit acceptable cleaning efficacy, leading to their wide acceptance. Some multipurpose
solutions have been shown to disinfect at a rate faster than their recommended time.55
Initial positive results with no-rub formulations56,57 were countered by other studies with varying results and led to more cautious recommendations.58,59 Since
then, many studies60,61,62,63,64,65 and a literature review66 have all recommended the reinstitution of rubbing as more effective than not rubbing.
Two separate outbreaks (Acanthamoeba and Fusarium) of keratitis were traced to multipurpose solutions.67,68 There has also been an increase in corneal
staining and low-grade infiltrates, 2 measures of solution-related toxicity. Low-impact lens/multipurpose solution combinations, daily disposable lenses or
hydrogen peroxide disinfection are recommended to minimize the risk of these complications. It has been suggested that RGP lenses should be rinsed with
saline before insertion and artificial tears be used for rewetting.69
Although the majority of contact lens wearers use a multipurpose solution, single-purpose solutions are still discussed for educational purposes.
Cleaning Solutions
Cleaning optimizes visual acuity, comfort, eye health and lens life and is the most important step in the proper care of all contact lenses.70 Debris from
numerous sources collects on the lens from the moment of insertion. The risk of complications such as blurred vision, ocular discomfort, local allergic
reactions, ocular infection or blindness increases as the interval between cleanings lengthens. Most contact lens wearers use a multipurpose solution for
cleaning their lenses. If they choose to use single-purpose solutions, there are two main types of cleaning solutions: surfactants (to remove loose debris) and
protein cleaners (to remove embedded protein). The global acceptance of disposable soft lenses has made protein cleaning almost obsolete for soft lenses; for
RGP lenses, enzyme cleaning is optional and is generally redundant when surfactants are properly used.
Since many contact lens contaminants are not water soluble, rinsing without cleaning is inadequate.71 Proper cleaning and rinsing can remove more than 99.9%
of the contaminants prior to disinfection.70 Surfactants emulsify and suspend organisms and other debris, thereby reducing contamination and facilitating
disinfection (the presence of debris can inactivate disinfectants).
Daily surfactant cleaning is similar for soft and RGP lenses. Surfactants for soft lenses contain preservatives that do not concentrate in the lens (e.g.,
polyquaternium-1). Immediately after lens removal, a few drops of surfactant are applied to each lens surface. The lenses are cleaned in the palm of the hand
using the index finger in a circular motion for 30–60 seconds. An alternative method involves vigorous friction rubbing between the thumb and forefinger for
30–60 seconds. The surfactant is then thoroughly rinsed off with a rinsing solution (normal saline or multipurpose solution) before disinfection. A surfactant
cleaner is used before an enzyme cleaner; the surfactant acts on the lipids that may hide protein deposits, making the enzyme cleaner more effective.
Surfactants must be thoroughly rinsed off the lens and hands to minimize the risk of chemical keratoconjunctivitis, stinging, allergic reactions, conjunctival
hyperemia and eyelid edema.71
Unorthodox cleaners include toothpaste, baking soda, laundry detergent, hair shampoo and skin cleaners.72 These nonsterile products can damage lenses and
are not recommended.
Disinfecting Solutions
A disinfectant actively kills microorganisms on lenses, while a preservative maintains the sterility of a solution.73 Some compounds can be used for both
purposes. Most disinfecting solutions for soft lenses contain disinfectants and preservatives. Some also contain surfactants but in a lower concentration than
in cleaning solutions, so disinfecting still requires a separate step.
Most contact lens wearers use a multipurpose solution for disinfection. If they choose to use single-purpose solutions, there are 2 basic forms of chemical
disinfection solutions for soft lenses: oxidizing agents (hydrogen peroxide) and disinfecting agents (e.g., polyquaternium-1, polyaminopropylbiguanide and
alkyltriethanolammonium chloride). Benzalkonium chloride (BAC) and chlorobutanol are used in solutions for RGP lenses only; these chemicals would be
adsorbed by the HEMA polymer in soft lenses and cause ocular tissue damage when they are subsequently released.73
Chemical disinfection of soft lenses is similar to the soaking process for RGP lenses, as the lenses are soaked or stored overnight in a chemical disinfecting
solution.74 All soft lenses can be chemically disinfected with the appropriate solution. After disinfection, soft lenses must be thoroughly rinsed with at least 25
mL of rinsing solution (usually normal saline or a multipurpose solution) before lenses are inserted into the eye. With RGP lenses, saline or the disinfecting
solution itself is used for rinsing. Water (e.g., tap, bottled, distilled) is not recommended for any lens because of potential accumulation of minerals in the lens
and possible microbial contamination.74,75
Hydrogen peroxide was one of the more popular chemical disinfectants for soft lenses, but use fell to less than 10% of chemical disinfection systems due to the
advent of more convenient multipurpose solutions.76,77 However, when used properly, hydrogen peroxide is the most effective chemical disinfectant and
produces the mildest ocular response when properly neutralized. Oxidizing agents like hydrogen peroxide are inherently unstable and, in the presence of organic
debris, form free radicals that attach to debris and disperse it.78 Their effervescence is a secondary means of removing debris from the lens matrix. Following
disinfection, hydrogen peroxide is neutralized by a platinum catalyst, sodium pyruvate, catalase or thiosulfite. Hydrogen peroxide does not affect the tints of
contact lenses, although hydrogen peroxide first aid products may cause tints to fade. Hydrogen peroxide first aid products are not designed for ophthalmic use
and may contain impurities, stabilizers and other additives that irritate ocular tissue.79,80
Commercially available hydrogen peroxide products come with a specially designed lens case that contains a built-in neutralizing disc, in which the lenses must
be soaked for 4–6 hours after disinfection, depending on the product. If the lenses are not soaked for the entire recommended duration, or not neutralized all
together, patients are at risk of placing unneutralized hydrogen peroxide into their eyes, which is highly irritating. Patients are commonly unaware that hydrogen
peroxide solutions differ from multipurpose solutions, and often experience eye irritation if not counseled appropriately.81 Advise patients that hydrogen
peroxide containers have red tips, which serve as a reminder that the solution is not safe to put directly into the eyes. Also, contact lenses must be free of
multipurpose solution before placing them in hydrogen peroxide; otherwise the solution will foam and overflow the lens case. To avoid this, rinse the lenses
thoroughly with the hydrogen peroxide solution before soaking them.
Wetting and Rewetting Solutions
Accessory solutions provide wetting/rewetting, lubrication and cushioning functions in various combinations.82 Wetting/rewetting agents are artificial tears
preserved with chemicals that are compatible with soft lenses. Lubrication and cushioning actions are imparted by viscosity agents, large colloidal molecules
(e.g., hydroxypropylcellulose, sodium hyaluronate) that increase resistance to flow, holding the tears in the eyes and reducing the drying-out effect of solutions.
They produce a cushioning and lubricant effect between the lens and eyelid and between the lens and cornea. Unlike wetting solutions without added viscosity
agents, lubricants do not enhance the flow of tears over the cornea. Wearers of silicone hydrogels who are suffering from dryness benefit from lubricants but
comforting effects seldom last longer than 1–2 hours, even with increasing viscosity.83
Solutions in this class have all 3 properties to varying degrees. Since the clinical significance of these differences is unknown, their uses are interchangeable.
Unit-dose or multidose saline is available in preserved or unpreserved formulations.84 Preserved saline minimizes the risk of contamination during repeated use.
Unpreserved unit-dose saline eliminates potential sensitivity reactions to preservatives. However, microbial contamination can occur if the solution stands for
longer than 1 hour or if it is used improperly.
Soft Lenses
Soft lenses tend to dry out throughout the day, especially in a dry or polluted environment, leading to dry eye symptoms in up to 75% of soft lens wearers.85
Additional risk factors for dry eye include the use of diuretics or hormones (e.g., oral contraceptives), lack of adequate tearing (e.g., due to age), certain
conditions (e.g., rheumatoid arthritis and to a lesser extent hypertension), air conditioning and low humidity. Dry eye is usually not associated with adherence
factors.86 Rewetting solutions can be used to relieve dryness, but limit use to 1 drop every 4–5 hours. More frequent use can result in red, irritated eyes and a
foreign body sensation. No one product is consistently superior to any other, although unpreserved solutions are generally recommended because they
minimize the potential for allergic reactions. Lubricants have not been found to be significantly superior to saline.85 Artificial tears that are not specifically
formulated for contact lenses should not be used for rewetting soft lenses because most contain preservatives (e.g., BAC) that can accumulate in the lens
matrix.
RGP Lenses
RGP lenses require wetting to reduce the foreign body sensation upon insertion.87 The mucin layer of the tear film contains highly hydrated polysaccharides
that wet the lens. However, this deposition can take up to 15 minutes to develop, during which time the wearer experiences discomfort. A wetting and
cushioning solution minimizes the transitional discomfort until the eyes adjust. The solution is applied to the concave side of the lens immediately before
insertion. Wetting agents reduce surface tension between tears and the contact lens or between tears and the cornea, allowing tears to spread evenly.
Although natural saliva has excellent wetting properties, it contains many potential pathogens and should never be used as a wetting agent.
Lens Cases
Store contact lenses in their cases, completely covered by disinfecting or multipurpose solution.88 If lenses dry out, their shape can temporarily change, rendering
them useless until they can regain their original shape. Maintain storage cases with the same vigilance as lenses, since a dirty case will nullify the previous steps
taken in the care of contact lenses. Even in asymptomatic contact lens wearers, the potential risk of fungal keratitis remains.89 About 40% of bacterial eye
infections among contact lens wearers can be attributed to carrying cases. Lens case care was the only area of improvement in an adherence study.90 Routinely (at
least monthly) boil storage cases in water for 10 minutes. Allow the lens case to cool for 30–45 minutes before lenses are placed in it. If a case can not be boiled at
least once a month, it should be replaced. Even when cleaned properly on a regular basis, replace a lens case every 3 months. Fortunately, lens case replacement is
being incorporated into PRPs. Replace the soaking solution daily. Flush the case of old solution and air-dry it before adding new solution.91 Digital rubbing, rinsing
with multipurpose solution, tissue wiping and air drying face down will reduce contamination further.92,93 Effective education can improve lens case hygiene.94
Care can be optimized when contact lens wearers are made aware of the many systemic and ophthalmic medications that can affect contact lenses by altering eye
shape, affecting the blink reflex, altering tear volume and composition, concentrating in the lens or discoloring the lens (Table 2 and Table 3). Inform the wearer that
drug-lens interactions are possible and can negatively affect the success of contact lens wear. Advise all wearers to maintain a current list of their medications and
share it with their eye care professional.
Resource Tips
American Optometric Association. Available from: www.aoa.org.
British Contact Lens Association. Available from: www.bcla.org.uk.
Canadian Association of Optometrists. Available from: www.opto.ca.
Contact Lens Association of Ophthalmologists. Available from: www.clao.org.
Algorithms
a,b
Figure 1: Steps for Proper Care of Soft Contact Lenses
a There may be variations to these regimens (e.g., an enzyme cleaner may not be required in a planned replacement program).
b With multipurpose solutions, 2 or more functions (usually cleaning and disinfecting, but may include rinsing and storing) are combined in 1 formulation.
Suggested Readings
Donshik PC, Ehlers WH, Anderson LD et al. Strategies to better engage, educate, and empower patient compliance and safe lens wear: compliance: what we know, what
we do not know, and what we need to know. Eye Contact Lens 2007;33:430-3.
Foulks GN. Prolonging contact lens wear and making contact lens wear safer. Am J Ophthalmol 2006;141:369-73.
Suchecki JK, Donshik P, Ehlers WH. Contact lens complications. Ophthalmol Clin North Am 2003;16:471-84.
Szczotka-Flynn LB, Pearlman E, Ghannoum M. Microbial contamination of contact lenses, lens care solutions and their accessories: a literature review. Eye Contact
Lens 2010;36:116-29.
U.S. Food and Drug Administration. FDA Executive Summary prepared for the May 13, 2014 Meeting of the Ophthalmic Devices Panel of the Medical Devices Advisory
Committee. Contact lens and care product guidance documents. Available from:
www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/OphthalmicDevicesPanel/UCM395577.pdf.
U.S. Food and Drug Administration. Hampton D. Contact lens safety. Available from:
www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/OphthalmicDevicesPanel/UCM397603.pdf.
Woods CA, Jones DA, Jones LW et al. A seven year survey of the contact lens prescribing habits of Canadian optometrists. Optom Vis Sci 2007;84:505-10.
60. Nichols JJ. Deposition rates and lens care influence on galyfilcon A silicone hydrogel lenses. Optom Vis Sci 2006;83:751-7.
61. Zhang S, Ahearn DG, Stulting RD et al. Differences among strains of the Fusarium oxysporum-F. solani complexes in their penetration of hydrogel contact
lenses and subsequent susceptibility to multipurpose contact lens disinfection solutions. Cornea 2007;26:1249-54.
62. Ahearn DG, Zhang S, Stulting RD et al. Fusarium keratitis and contact lens wear: facts and speculations. Med Mycol 2008;46:397-410.
63. Cho P, Cheng SY, Chan WY et al. Soft contact lens cleaning: rub or no-rub? Ophthalmic Physiol Opt 2009;29:49-57.
64. Kilvington S, Lonnen J. A comparison of regimen methods for the removal and inactivation of bacteria, fungi and Acanthamoeba from two types of silicone
hydrogel lenses. Cont Lens Anterior Eye 2009;32:73-7.
65. Zhu H, Bandara MB, Vijay AK et al. Importance of rub and rinse in use of multipurpose contact lens solution. Optom Vis Sci 2011;88:967-72.
66. Butcko V, McMahon TT, Joslin CE et al. Microbial keratitis and the role of rub and rinsing. Eye Contact Lens 2007;33:421-3.
67. Patel A, Hammersmith K. Contact lens-related microbial keratitis: recent outbreaks. Curr Opin Ophthalmol 2008;19:302-6.
68. Tu EY, Joslin CE. Recent outbreaks of atypical contact lens-related keratitis: what have we learned? Am J Ophthalmol 2010;150:602-8.
69. Choy CK, Cho P, Boost MV. Cytotoxicity of rigid gas-permeable lens care solutions. Clin Exp Optom 2013;96:467-71.
70. Sibley MJ, Shih KL, Hu JC. The microbiological benefit of cleaning and rinsing contact lenses. Int Contact Lens Clin 1985;12:235-42.
71. Sibley MJ. Cleaning solutions for contact lenses. Int Contact Lens Clin 1982;9:291-4.
72. Diefenbach CB, Seibert CK, Davis LJ. Analysis of two “home remedy” contact lens cleaners. J Am Optom Assoc 1988;59:518-21.
73. Ernst RR. Sterilization by heat. In: Block SS, ed. Disinfection, sterilization and preservation. 2nd ed. Philadelphia: Lea & Febiger; 1977. p. 481-521.
74. Sibley MJ. Disinfection solutions. Int Ophthalmol Clin 1981;21:237-47.
75. Penland RL, Wilhelmus KR. Microbiologic analysis of bottled water: is it safe with contact lenses? Ophthalmology 1999;106:1500-3.
76. Holden B. A report card on hydrogen peroxide for contact lens disinfection. CLAO J 1990;16:S61-4.
77. Johnson & Johnson Vision Care. 2000 survey data. Markham: Johnson & Johnson Vision Care.
78. Gasset AR, Ramer RM, Katzin D. Hydrogen peroxide sterilization of hydrophilic contact lenses. Arch Ophthalmol 1975;93:412-5.
79. Gordon KD. The effect of oxidative disinfecting systems on tinted hydrogel lenses. Can J Optom 1989;51:175-6.
80. Anonymous. Contact lens questions and answers. Generic peroxide. Rev Optom 1986;123:77.
81. Health Canada. Product confusion alert. Risk of eye injury with improper use of hydrogen peroxide-based contact lens solution. Health Product InfoWatch 2016
February. Available from: www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2016-02-eng.php. Accessed April 6, 2016.
82. Weissman BA, Tari LA. A solution for the dry eye. Contact Lens Forum 1982:5-7.
83. Ozkan J, Papas E. Lubricant effects on low Dk and silicone hydrogel lens comfort. Optom Vis Sci 2008;85:773-7.
84. Harris MG, Higa CK, Lacey LL et al. The pH of aerosol saline solution. Optom Vis Sci 1990;67:84-8.
85. Efron N, Golding TR, Brennan NA. The effect of soft lens lubricants on symptoms and lens dehydration. CLAO J 1991;17:114-9.
86. Ramamoorthy P, Nichols JJ. Compliance factors associated with contact lens-related dry eye. Eye Contact Lens 2014;40:17-22.
87. Mauger TF, Hill RM. Solutions that soothe. Contact Lens Forum 1982:75-7.
88. Simmons PA, Edrington TB, Hsieh L et al. Bacterial contamination rate of soft contact lens cases. Int Contact Lens Clin 1991;18:188-91.
89. Mela EK, Anastassiou ED, Gartaganis SP et al. Fungal isolation from disinfection solutions of contact lens storage cases among asymptomatic users. Eye
Contact Lens 2015;41:87-90.
90. Yung AM, Boost MV, Cho P et al. The effect of a compliance enhancement strategy (self-review) on the level of lens care compliance and contamination of
contact lenses and lens case accessories. Clin Exp Optom 2007;90:190-202.
91. Larragoiti ND, Diamos ME, Simmons PA et al. A comparative study of techniques for decreasing contact lens storage contamination. J Am Optom Assoc
1994;65:161-3.
92. Wu YT, Teng YJ, Nicholas M et al. Impact of lens case hygiene guidelines on contact lens case contamination. Optom Vis Sci 2011;88:E1180-7.
93. Wu YT, Zhu H, Willcox M et al. The effectiveness of various cleaning regimens and current guidelines in contact lens case biofilm removal. Invest Ophthalmol Vis
Sci 2011;52:5287-92.
94. Tilia D, Lazon de la Jara P, Zhu H et al. The effect of compliance on contact lens case contamination. Optom Vis Sci 2014;91:262-71.

Contact Lenses and Cosmetics
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients. Once printed there is no quarantee the information is up-to-date.
[Printed on: 07-31-2017 12:12 PM]
Dry Eye

Date of Revision: February 2017
Pathophysiology
Anatomy/Physiology
The lacrimal functional unit is composed of the lacrimal glands, the ocular surface (cornea and
conjunctiva), meibomian glands, eyelids and the sensory and motor nerves that connect them. This unit
controls the production of the tear film and responds to environmental, endocrine and cortical influences
in order to maintain the tear film, the transparency of the cornea and the quality of the image projected
onto the retina.
The tear film is composed of 3 layers:
The mucous layer is the layer closest to the eye and contains multiple mucins, produced by goblet
cells in the conjunctiva. It stabilizes the tear film by interacting with epithelial layers in the cornea
and conjunctiva and the aqueous layer. It also removes waste materials such as mucous threads
and fibrils.
The aqueous layer is the thickest part of the tear film and is produced by the lacrimal glands. It
contains inorganic salts, glucose, urea, trace elements, antibacterial proteins (including lactoferrin
and lysozyme), vitamins (particularly vitamin A) and growth factors. This layer hydrates the mucous
layer, supplies oxygen and electrolytes to the ocular surface and provides antibacterial defense and
wound healing.
The lipid layer is primarily secreted by the meibomian glands and is the outermost layer of the tear
film. It is responsible for slowing tear evaporation, enhancing tear film spreading and providing a
smooth optical surface.
Although this is the classic view of the tear film, it is probably better described as a hydrated, mucin gel,
where the mucin concentration is highest at the epithelial cell surface (the eye) and lowest as it comes in
contact with the air.1,2
Dry Eye Disease
The International Dry Eye Workshop (2007) defined dry eye disease (DED) as “a multifactorial disease of
the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film
instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the
tear film and inflammation of the ocular surface”.3
DED has 2 major classifications: aqueous tear-deficient dry eye (Table 1) and evaporative dry eye (Table
2). However, there can be considerable overlap between these classes and DED may involve multiple
mechanisms.1,3,4,5,7 For example, contact lens wearers may experience decreased corneal sensitivity
with reflex sensory block, leading to aqueous deficiency. These patients may also blink less, which can
result in increased tear evaporation. There may also be incomplete lid closure during blinking, leading to
further evaporation of the tear film. If the patient is also taking a medication with anticholinergic side
effects, tear secretion may be decreased even further.8
Regardless of the mechanism(s) for the development of DED, the impact on a patient's quality of life can
be significant. Severe DED may result in ocular surface erosions, epithelial damage and, rarely, ocular
surface keratinization, ulceration, perforation, scarring and markedly reduced vision.1,3,5,9,10
In all severities, an individual with dry eye disease (DED) can experience disturbances in their activities of
daily living such as computer use, reading, driving and watching television, thus negatively impacting
their quality of life and occupational function.11 A meta-analysis found that individuals with DED had an
increased prevalence of depression (OR = 2.92) and anxiety (OR = 2.8) compared with those who did not
have DED. Through subgroup analysis, this study also found that depression and anxiety were more
severe in patients with primary Sjogren’s syndrome.12 [Evidence: SORT B] Though the causal relationship
between DED and these psychiatric comorbidities is not yet established, practitioners should be aware of
this association and should be cautious when selecting treatment options for psychiatric conditions, as
antidepressants may exacerbate DED through their anticholinergic effects. Because it may not be
practical to screen all patients with DED for psychiatric comorbidities, screening should occur in those
with primary Sjogren's syndrome or those with DED whose subjective symptoms appear to be more
severe than objective signs would suggest. See Depression and Anxiety Disorders for more information
on screening tools.
Aging is a risk factor for the development of DED.3,4,5,13 Also, DED occurs more often in females;
however, this may be more related to the finding that androgen deficiency promotes meibomian gland
dysfunction (MGD), leading to evaporative DED.
Occupational risk factors include prolonged visual attention to a task (e.g., looking through a
microscope, working at a computer) resulting in a reduced blink rate.3,4 Tasks that require an upward
gaze (e.g., playing billiards) can expose more of the ocular surface, resulting in greater tear film
evaporation. Likewise, patients with a naturally wider palpebral aperture expose more of the ocular
surface to evaporation.
Environmental factors that lead to DED include low humidity, high temperature, wind or high air velocity
and air pollution (e.g., tobacco smoke).1,3,4,14 A diet low in omega-3 fatty acids or vitamin A may also
contribute to DED.
Systemic medications may play an important role in the development or progression of DED (see
Prevention).3,4,5,8,15,16
Diagnosis of DED can prove difficult as symptoms do not necessarily reflect the severity of the
disease.1,3,4 Patients who are highly symptomatic may not have clinical evidence of DED, while some
patients who already have damage to the ocular surface may not complain of symptoms. This lack of
concordance between signs and symptoms makes it difficult for investigators to meet primary efficacy
endpoints in DED trials.
Table 1: Classification of Aqueous Tear-deficient Dry Eye
Non-Sjögren1,3,4,5 Lacrimal gland Primary: Age-related, congenital

deficiency alacrima, familial dysautonomia
Secondary: Lacrimal gland infiltration,

e.g., in sarcoidosis, lymphoma, AIDS,
graft-versus-host disease; lacrimal gland
ablation; lacrimal gland denervation
Lacrimal duct Trachoma, cicatricial pemphigoid,

obstruction mucous membrane pemphigoid,
erythema multiforme, chemical and
thermal burns
Reflex hyposecretion Sensory block: Secondary to factors that

decrease corneal sensation including
corneal surgery (e.g., LASIK, PRK),
contact lens wear, diabetes mellitus,
ophthalmic infection (e.g., herpes
simplex keratitis, herpes zoster
ophthalmicus), neurotrophic keratitis
Motor block: Secondary to damage to

the VII cranial nerve; neuromatosis;
systemic medication use
Sjögren6 Primary Autoimmune disease affecting exocrine

glands
Secondary Associated with other autoimmune

diseases, e.g., rheumatoid arthritis,
systemic lupus erythematosus
1,3,4,5
Table 2: Classification of Evaporative Dry Eye
Intrinsic Meibomian gland dysfunction: Associated with
dermatoses such as acne rosacea, seborrheic
dermatitis and atopic dermatitis
Medications: Isotretinoin therapy
Disorders of lid aperture: Exophthalmos

(hyperthyroidism; eyelid deformity; poor lid
apposition)
Low blink rate: Parkinson's disease
Extrinsic Decreased blink rate: Tends to occur during

activities such as reading, watching television,
computer work
Ocular surface abnormalities: Vitamin A

deficiency; exposure to eye drops containing
benzalkonium chloride or anesthetic agents
Contact lens wear
Allergic conjunctivitis
Goals of Therapy
Ease patient discomfort and minimize symptoms
Prevent or delay complications
Educate patients about their condition and encourage adherence, especially in those with long-term
disease
Patient Assessment
Conditions.
Patients with DED may complain of a foreign body sensation in the eye.3,4,5 Words like “sandy” or “scratchy”
are used to convey this symptom. Eyes often feel like they are burning, itchy or tired. Other symptoms
include photophobia, blurred vision, redness, discomfort and difficulty in moving the lids.
Although most patients state that their eyes feel dry, some will report increased tearing, especially when
exposed to wind or when concentrating on tasks such as reading or computer work.3,4,5 This is a reflex
tearing that does little to increase comfort.
Unlike blepharitis and conjunctivitis, dry eye symptoms tend to worsen over the course of the day.3,4
Prevention
Many systemic medications have the potential to cause DED, including amiodarone, antiandrogenic agents,
anticholinergics or medications with anticholinergic side effects, beta-blockers, diuretics, interferon,
isotretinoin and postmenopausal hormone replacement therapy.3,17,18 Natural health products have also
been known to cause DED; niacin, echinacea, kava kava, and herbal products that contain anticholinergic
alkaloids have all been associated with DED.19 Frequent use of eye drops, particularly those containing
benzalkonium chloride as a preservative, may contribute to DED by further damaging the ocular
surface.20,21,22 Advise patients of this potential effect and provide treatment options in case it occurs.
Contact lens wearers need to pay careful attention to proper cleaning and wear of their lenses (see Contact
Lens Care). It is common to blink less frequently during activities requiring concentration such as reading,
computer work and video games; remind patients to blink more often during these activities. Encourage
patients with chronic blepharitis to maintain lid hygiene. Ask patients with autoimmune or dermatologic
diseases (e.g., Sjögren syndrome, rheumatoid arthritis, systemic lupus erythematosus, acne rosacea) about
any symptoms of dry eye. Because of the severity of DED that has been associated with these diseases,
referral to an eye care practitioner may be suggested to optimize therapy and prevent complications.
Nonpharmacologic therapy of DED may involve environmental changes.6,9,15,23 Encourage patients to avoid
smoking and smoky rooms since tobacco smoke is a common cause of eye irritation. Humidifiers,
especially in winter, can improve conditions for dry eye sufferers. Moisture chamber spectacles, or ski or
swim goggles, can be worn to increase humidity in the eye area as well as decrease the evaporation of
tears. A moistened gauze placed inside the goggles helps maintain a moist environment. A cool, moist
washcloth placed over closed eyelids may provide short-term relief.
In severe or chronic DED, tear duct (punctal) occlusion may be used to prevent drainage of existing tears via
the nasolacrimal ducts. Punctal plugs, inserted by an eye care practitioner trained in this technique, are used
to assess whether a patient will benefit from this treatment.3,17,23,24,25 It is possible to dislodge the plugs,
especially if patients rub their eyelids. Therefore, nasolacrimal occlusion for eye drop instillation is not
recommended or required in patients with punctal plugs. Permanent occlusion can be achieved through
heat or electrocautery but can also occur spontaneously following insertion of punctal plugs, and can
persist even after the plugs are lost.26
Ailments—Ophthalmic Products: Ocular Lubricants.
Pharmacologic therapy generally begins with administration of artificial tears that contain a volume-
enhancing agent to supplement tear production or an ocular lubricant that contains a contact-enhancing
agent to help retain existing tears.3,23 Artificial tear drops have demonstrated efficacy for relieving
symptoms of DED in several clinical trials.27
Although there are a number of solutions available, it is difficult to identify the solution of choice in DED.
Clinical trials do not provide definitive conclusions because of the difficulty in meeting primary efficacy
endpoints. Much of the information relating to pharmacologic treatments is proprietary, and large, head-to-
head clinical trials are lacking.27 Until more evidence is available, choosing the best therapy is achieved
through a trial and error approach.2,3,17,18,23,25,28,29 This can be frustrating, both for the patient and for the
healthcare practitioner. A 1- to 2-week trial of eye drops is needed to determine the subjective efficacy of the
product (patient comfort, improvement in symptoms).
Consider the following factors in choosing a tear replacement product:
Electrolyte composition:3,17,18,23,25 Potassium and bicarbonate are the most critical electrolytes.
Potassium is important in maintaining corneal thickness, while bicarbonate appears to aid the recovery
of epithelial barrier function in a cornea that has already been damaged. It may also be important in
maintaining the mucous layer of the tear film
Crystalloid osmolarity (the concentration of small dissolved particles, such as ions):3,17,18,23,25
Patients with DED have a higher tear film osmolarity than the normal population. This results in
biochemical changes to the cornea and a pro-inflammatory state. Hypo-osmotic tears were developed
to counteract this increased osmolarity
Colloidal osmolality (the concentration of macromolecules or compatible solutes):3,17,18,23,25 Also
known as oncotic pressure, this relates to water transport across the ocular surface epithelium. An
artificial tear product with a high colloidal osmolality could protect against epithelial damage from
hyperosmolar tears by stabilizing the volume of corneal epithelial cells. Compatible solutes (e.g.,
glycerin) are taken up by cells, increasing intracellular osmolarity so that the cells do not have to
increase their internal electrolyte concentration to achieve the same goal
Viscosity agents:3,7,17,18,20,25 Artificial tear products with higher viscosity increase tear retention time
and help protect the ocular surface. However, they are merely a palliative treatment. These agents
include substituted cellulose ethers such as carboxymethyl cellulose and hypromellose
(hydroxypropylmethylcellulose), polyvinyl alcohol, polyethylene glycol, glycol 400 and propylene
glycol. Hydroxypropyl-guar (HP-guar) appears to form a bioadhesive gel when exposed to the eye,
protecting the eye by mimicking the mucous layer of the tear film. Castor oil or mineral oil may be used
in ocular lubricants to decrease tear evaporation by restoring the lipid layer of the tear film. Sodium
hyaluronate is a polysaccharide polymer that acts as a viscoelastic solution at physiologic pH, with a
viscosity 500 000 times that of saline. Ophthalmic solutions in concentrations of 0.1–0.5% have been
successful in treating symptoms of dry eye. Carbomer resins are synthetic high molecular weight
polymers of acrylic acid cross-linked to a polyalkyl polyether. Although carbomer 940 resembles an
ointment, it causes less blurred vision than petrolatum-based ophthalmic ointments
Cytotoxic additives:3,17,18,23,25 Ethylenediaminetetraacetic acid (EDTA), an additive in some eye drops,
can damage corneal epithelial cells. Lanolin is an additive in some ophthalmic ointments but can
cause ocular irritation especially in patients who are sensitive to wool
Preservatives:3,30,31,32
Advise patients with mild dry eye who require more than 4 applications per day for long periods of
time to use a preservative-free product to prevent toxicity. The detergent preservative
benzalkonium chloride is the most frequently used preservative in eye drops. However, it is
known to be toxic to the corneal epithelium. Advise patients with moderate to severe DED to avoid
benzalkonium chloride whenever possible3,4,17,20
Oxidative preservatives, such as polyquaternium-1 (Polyquad), sodium chlorite (Purite) or sodium

perborate are safer alternatives to benzalkonium chloride. The latter 2 preservatives are termed
“vanishing” preservatives: sodium chlorite degrades to chloride ions and water after instillation,
while sodium perborate converts to water and oxygen after making contact with the tear film.
However, these preservatives may not always disappear completely in patients with moderate to
severe DED because of decreased tear volume
Ophthalmic ointments do not support bacterial growth and generally do not require preservatives.
Petrolatum-containing ophthalmic ointments have a longer retention time in the eye than drops
but can cause unacceptable blurred vision. This limits their application to bedtime use for most
patients.
A long-acting artificial tear containing hyprolose (hydroxypropylcellulose) is available as an insert to be

placed in the conjunctival sac daily or twice daily, depending on dry eye severity. It dissolves over several
hours, allowing long-term ocular lubrication. Blurred vision is common for the first few hours, but it is
preservative-free. Manual dexterity and education are required for proper insertion. Ophthalmic anti-
inflammatories such as cyclosporine and loteprednol are used in the management of patients who are not
responsive to ocular lubricants and artificial tears.33
Autologous serum eye drops have been used to treat DED.34,35 They contain biologically active substances
required to maintain the tear film, which are believed to be a better substitute than artificial tears. Concerns
about autologous serum eye drops include the risk of microbial growth in the protein-rich product and the
risks associated with periodic patient blood draws. The optimal concentration and diluent are also unknown.
A Cochrane review reported insufficient evidence to prove the safety and efficacy of autologous serum eye
drops for the treatment of DED; high-quality randomized control trials are required.36
Other treatments that have been investigated for severe dry eye include topical acetylcysteine9,20,23
(removes excessive mucus), topical methylprednisolone,37 topical estradiol38 and periorbital intramuscular
injections of botulinum toxin.39
For more detailed information regarding ophthalmic products used in the management of dry eye disease,
consult the Compendium of Therapeutic Choices: Red Eye.
Patients with meibomian gland dysfunction associated–DED may benefit from omega-3 fatty acid–rich
foods or supplementation.40,41 Omega-3 fatty acids are thought to have anti-inflammatory properties which
may reduce the inflammatory component of DED.42,43,44 Preliminary evidence suggests that even omega-6
fatty acids, which are considered pro-inflammatory, show some benefit in decreasing the symptoms of
DED.42 Randomized controlled trials have demonstrated that supplementation with omega-3 fatty acids
increases tear break-up time (TBUT) and significantly improves dry eye symptoms.45,46 Encourage patients
to consume higher amounts of food rich in omega-3 fatty acids (herring, mackerel, salmon, sardines, tuna,
canola oil, chia, and pumpkin and sunflower seeds). Flaxseed and flaxseed oil are other sources of omega-3
fatty acids.42,47
Oral pilocarpine is indicated for the treatment of dry eye associated with Sjögren syndrome.48
Patients with intermittent symptoms of dry eye can be treated effectively with 1 or more of the numerous
ocular lubricants available. The patient should be assessed if symptoms do not resolve within 3–5 days or if
they worsen.
Signs of preservative toxicity include stinging upon instillation and conjunctival inflammation.3,4,17,20 If
these symptoms are present, the patient may need a product with a different preservative, a preservative-
free product or referral for assessment.
Periodic assessment of eye drop and ointment instillation technique will help patients make best use of the
agents (see Eyelid Conditions: Hordeolum, Chalazion and Blepharitis, Proper Use of Eye Drops, Proper Use
of Eye Ointments—What You Need to Know). Devices such as the Auto-Drop and Auto-Squeeze (Owen
Mumford, www.owenmumford.com) are usually available through local wholesalers and can be offered to
patients to aid in ocular medication administration.
Resource Tips
eMedicine from WebMD. Foster CS, Yuksel E. Dry eye syndrome. Available from: emedicine.medscape.com.
Registration required.
Suggested Readings
Bron AJ, Tomlinson A, Foulks GN et al. Rethinking dry eye disease: a perspective on clinical implications.
Ocul Surf 2014;12:S1-31.
Ophthalmic Products: Ocular Lubricants

Artificial Tears Actavis drops glycerin 0.2%
hypromellose 0.2%
Artificial Tears Pendopharm drops polyvinyl alcohol 1.4%
Artificial Tears Extra Pendopharm drops polyvinyl alcohol 1.4%

povidone 0.6%
Bion Tears Alcon drops dextran 70 0.1%

hypromellose 0.3%
Celluvisc Allergan drops sodium carboxymethylcellulose

1%
Duolube Bausch & Lomb ointment petrolatum 80%

petrolatum liquid 20%
Genteal Novartis drops hypromellose 0.3%

Ophthalmics
Isopto Tears 0.5% Alcon drops hypromellose 0.5%
Isopto Tears 1% Alcon drops hypromellose 1%
Lacri-Lube S.O.P. Allergan ointment mineral oil 42.5%

petrolatum 55.5%
Lacrisert Ophthalmic Aton ophthalmic hydroxypropyl cellulose

Inserts insert (hyprolose) 5 mg
Moisture Drops Bausch & Lomb drops glycerin 0.2%

hypromellose 0.5%
polyvinyl pyrrolidone 0.1%
Murine Eye Care Abbott drops polyvinyl alcohol 0.5%

povidone 0.6%
Ocunox CandorVision ointment retinol palmitate 250 units/g
Refresh Allergan drops, unit dose polyvinyl alcohol 1.4%
Refresh Liquigel Allergan solution sodium carboxymethylcellulose

1%
Refresh Optive Advanced Allergan drops glycerin 1%
polysorbate 80 0.5%
sodium carboxymethylcellulose
0.5%
Refresh Optive Fusion Allergan drops glycerin 0.9%

sodium carboxymethylcellulose
0.5%
Refresh Tears Allergan drops sodium carboxymethylcellulose

0.5%
Systane Alcon drops polyethylene glycol 400 0.4%

propylene glycol
Systane Ointment Alcon ointment lanolin 3%

mineral oil 3%
petrolatum 94%
Tear Drops Novartis drops polyvinyl alcohol 1.4%

Ophthalmics povidone 0.6%
Tear-Gela Alcon gel carbomer 980

disodium edetate
sorbitol
Tears Naturale Alcon drops dextran 70 0.1%

hypromellose 0.3%
Tears Naturale II Alcon drops dextran 70 0.1%

Lubricant Eye Drops hypromellose 0.3%
Tears Naturale Free Alcon drops, unit dose dextran 70 0.1%

hypromellose 0.3%
Tears Plus Allergan drops polyvinyl alcohol 1.4%
TheraTears Advanced Vision drops sodium carboxymethylcellulose

Research 0.25%
VisineEye Revival Johnson & drops glycerin 0.2%

Johnson hypromellose 0.2%
VisineTired Eye Relief Johnson & drops glycerin 0.2%

Johnson hypromellose 0.2%
a Ingredient strengths not available.

Eyelid Conditions: Hordeolum, Chalazion and Blepharitis

Eye Anatomy
Eyelids and lashes protect the globe (eyeball) from foreign bodies and injuries and help maintain a wet
corneal surface. The eyelid is a complex structure of skin, muscle and fibrous tissue. The skin of the eyelid
is among the thinnest anywhere on the body, which allows for the mobility of the eyelids. Underneath the
skin lies loose, areolar tissue that is capable of significant edema and swelling. The next layer is the
orbicularis muscle, responsible for closing the eyelids and innervated by the seventh cranial nerve.1,2
Posteriorly in the eyelid is the tarsus, a dense fibrous connective tissue plate that supports the lid margins
and forms the skeleton of the eyelid (Figure 1). Modified sebaceous glands, known as meibomian glands,
are contained within the tarsal plates and secrete the lipid layer of the tear film. There are 20–30 glands in
the upper lid and 10–20 in the lower lid.1,2,3
The glands of Zeis and Moll lie in the anterior section of the eyelid. Zeis's glands are modified sebaceous
glands that are associated with the lash follicles. Moll's glands are modified sweat glands whose ducts
open either into a lash follicle or directly onto the anterior lid margin between the lashes (Figure 2).4
Figure 1: Anatomy of the Eyelids and Anterior Eye
Figure 2: Cross-section of Upper Eyelid
Hordeolum
Pathophysiology
A hordeolum (stye) is an infection of the sebaceous glands of the eyelids. It is the most common eyelid
infection in ophthalmology.3,5,6,7 When the glands of Zeis are involved, the infection is smaller, more
superficial and referred to as an external hordeolum. In this type of infection the lesion always points toward
the skin. An internal hordeolum is marked by a larger swelling that usually involves the meibomian glands,
and the lesion can point either to the skin or to the conjunctival surface. As compared with the external stye,
the internal hordeolum generally has a more prolonged course because it rarely drains spontaneously.
Microbiologic cultures are seldom required for either type of hordeolum since the most common infecting
organism is Staphylococcus aureus.
Goals of Therapy
Resolve infection
Prevent recurrence
Prevent transmission to other eye or to household contacts
Patient Assessment
Patients with hordeolum present with unilateral, localized lid swelling, tenderness and erythema. The
amount of discomfort increases with the degree of lid swelling. Hordeola are often associated with
blepharitis and have a tendency to recur.2,5
Conditions.
Prevention
A common sense approach to avoid infecting the fellow eye or transmitting the infection to other persons in
the household includes the following instructions for the patient:
Avoid touching the eyes and wash the hands after any contact with the infected eye.
Change compresses and towels after each use.
Take care not to allow the tip of eye drop bottles or ophthalmic ointments to touch the eye or
eyelashes.
Conscientious attention to treating symptoms of blepharitis may help to decrease the incidence of recurrent
hordeola.
External hordeola usually drain spontaneously within 48 hours, but warm compresses applied for 10–15
minutes 3 or 4 times a day may hasten resolution.2,3,8 Following the application of warm compresses,
gently massaging the eyelid toward the lid margin can also be helpful. Warm tap water is sufficient to use in
compresses. There is a risk of burning the skin when using the microwave to heat warm compresses.9 One
study showed that a hard-boiled egg, kept in the shell, retained heat longer than a warm compress.10 The
authors suggest that a hard-boiled egg wrapped in a handkerchief or compress is a convenient and cost-
effective way to apply heat to the eyelid. The same egg can be reboiled prior to each application. Caution
patients against applying pressure on the warm compress or hard-boiled egg, as corneal deformation can
occur resulting in blurred vision (usually transient following short-term use).11,12 If patients find it difficult to
control the amount of pressure using the hard-boiled egg, they may try bending forward and holding the
wrapped egg close to the eye without touching it.11 Patients should seek medical advice if they have
external hordeola that do not spontaneously drain within 48 hours. In these situations incision and drainage
may be required.2,3,8,13
Acute internal hordeola generally resolve within 1–2 weeks and can be treated with warm compresses for
5–10 minutes several times a day. Patients should seek medical advice if they have internal hordeola that
do not resolve spontaneously in 1 week.13,14
Self-medication with nonprescription ophthalmic antibacterials is not necessary and is not recommended.15
If incision and drainage are required, an ophthalmic antibacterial ointment such as bacitracin or
erythromycin, applied to the conjunctival sac several times a day, may help prevent further infection.2,3,8 The
presence of cellulitis is an indication for the use of systemic antibacterials.
For further discussion of pharmacologic therapy for bacterial eye infections, consult the Compendium of
.....
Chalazion
Pathophysiology
A chalazion is an idiopathic, sterile, chronic inflammation of a meibomian gland. Blockage of the meibomian
gland orifices results in stagnation of sebaceous secretions.2,8,16 A lesion develops over a period of weeks
and is characterized by painless, localized swelling. Most chalazia point toward the conjunctival surface,
causing conjunctival redness and swelling.
Chalazia are more common in people with blepharitis, acne rosacea or seborrheic dermatitis. Other risk
factors for chalazion include smoking, gastritis and irritable bowel syndrome.17 These patients are also at
greater risk of developing multiple or recurrent chalazia. Patients with recurrent or persistent chalazion
require evaluation for more serious conditions such as meibomian gland carcinoma.
Goals of Therapy
Resolve lesion
Prevent recurrence
Patient Assessment
The initial symptoms of chalazion (mild inflammation and tenderness) may resemble hordeolum, but
without the acute inflammatory signs.1,2,16 Chalazia may be distinguished from hordeola by the lack of
pain.18
Large chalazia may press on the eyeball and cause astigmatism or visual distortion. An algorithm for the
assessment of eye conditions is presented in Assessment of Patients with Eye Conditions.
Prevention
Encourage patients who have recurrent chalazia associated with blepharitis to maintain good lid hygiene
(see Blepharitis, Nonpharmacologic Therapy). Advise patients with dermatologic conditions such as acne
rosacea and seborrheic dermatitis to adhere to treatment of these conditions. Encourage and support
smoking cessation.
Initial treatment for chalazion is similar to that for hordeolum, especially for small lesions.16,19,20 Warm
compresses, applied several times a day, are used to soften sebaceous secretions that may be blocking
meibomian gland orifices. Approximately 25–50% of lesions resolve with this treatment. Following the
application of warm compresses, gently massaging the eyelid toward the lid margin may also be helpful.
Further assessment is required if the lesion does not begin to resolve within a few days of initiating warm
compress treatment. Immediate referral to an appropriate healthcare practitioner is required for patients
experiencing eye pain or impaired vision.
Self-medication with nonprescription ophthalmic antibacterials is not necessary and is not recommended
for chalazia.1,16,18
Larger chalazia may require surgical excision, intralesional steroid injections, or both.16,19,20 These
procedures should be performed by an ophthalmologist. When excision is required, the ophthalmologist
makes a vertical incision on the conjunctival surface, followed by careful curettement of the gelatinous
material. Topical antibacterials or corticosteroid drops may be prescribed after surgery to prevent infection
and decrease inflammation. The presence of cellulitis is an indication for the use of systemic antibacterials.
For further information on ophthalmic therapy, consult the Compendium of Therapeutic Choices: Red Eye.
.....
Blepharitis
Pathophysiology
Blepharitis is a chronic condition, with periods of exacerbation, that usually affects the eyelids bilaterally.6,7
Although the different types can be defined as anterior and posterior, blepharitis often occurs as a mixed
condition in patients, making it difficult to accurately diagnose and treat. It is often associated with chronic
dermatologic conditions such as acne rosacea and seborrheic dermatitis,21 as well as pterygia, ulcerative
colitis, irritable bowel syndrome, anxiety and gastritis.22 These conditions must also be treated, for optimal
control of blepharitis.
Long-term complications of this chronic disorder include physical damage to the eyelids and the cornea.6,7
Inflammation of the cornea can result in scarring, loss of surface smoothness and loss of visual acuity. If
the inflammation is severe, corneal perforation may occur.
Anterior Blepharitis
Staphylococcal blepharitis is usually caused by S. aureus or S. epidermidis.6,7 Patients present with

inflammation and erythema along the anterior margin of the eyelid. The lid margins are scaly, with crusts
and tiny ulcerations around the lashes. In chronic inflammatory staphylococcal blepharitis, loss of
eyelashes (madarosis) may occur. Complications of staphylococcal blepharitis include recurrent
hordeola or chalazia, epithelial keratitis of the lower third of the cornea and marginal corneal infiltrates.
Seborrheic blepharitis (nonulcerative) presents with less inflammation and redness along the anterior
border of the eyelid and the scales are more oily or greasy than in staphylococcal blepharitis.6,7
Seborrheic blepharitis is often associated with seborrheic dermatitis affecting other parts of the body.
Although 2 types of anterior blepharitis have been identified, it is more common for patients to present
with a mix of staphylococcal and seborrheic types.6,7 Patients with either form of anterior blepharitis are
also predisposed to developing conjunctivitis.
Posterior Blepharitis
Meibomian gland dysfunction can lead to inflammation of the posterior aspect of the eyelid (closer to
the eyeball).2,6,7 This is a bilateral, chronic condition that sometimes coexists with anterior blepharitis.
Meibomian seborrhea is characterized by excessive glandular secretions.2,6,7 Symptoms can include

photophobia, burning sensation, an excessively oily or foamy tear film and froth on the lid margin.
Although they may be difficult to detect, small oil globules may be sitting at the meibomian gland orifices
on the lid margin. There are usually few signs of inflammation.
Meibomianitis is characterized by inflammation and obstruction of the meibomian glands.2,6,7 Signs

include diffuse or localized inflammation of the posterior lid margin. In chronic cases the meibomian
gland orifices become obstructed and the posterior lid margin may become thick, rounded and notched.
When pressure is applied over the glands, a soft cheesy substance is expressed. In very severe cases the
glands are completely blocked so no secretions can be expressed.
Goals of Therapy
Reduce inflammation and discomfort associated with blepharitis
Reduce the risk of recurrence of severe symptoms
Reduce the risk of complications such as conjunctivitis and keratitis
Patient Assessment
Generally, symptoms of blepharitis include irritation, burning and itching of the lid margins. There may also
be a foreign-body sensation in the eye.7,23,24 Patients may complain of a sandy or gritty sensation in the
eyes that is worse upon awakening since, during sleep, the inflamed eyelids lie against the cornea, tear
secretion decreases, and inflammatory mediators have several hours to act on the surface of the eye. See
also Pathophysiology, anterior and posterior blepharitis.
Conditions.
Prevention
Blepharitis is almost always a chronic condition that frustrates patients, physicians and eye care
practitioners. Inadequate instruction and nonadherence with lid hygiene are the most common reasons for
treatment failure.8 Encourage patients to maintain a long-term lid hygiene program as this helps prevent
exacerbations and long-term complications. Treatment of dermatologic disorders elsewhere in the body,
such as seborrheic dermatitis, is important in achieving long-term control of blepharitis.5,15,23
Ailments—Ophthalmic Products: Cleansers and Washes.
Treatment for all types of blepharitis consists of regular and long-term eyelid margin hygiene:6,23,24,25
1. Warm compresses, applied to closed eyelids for 5–10 minutes, help to melt solidified material in the
glands
2. Gentle cleansing of the lid margin follows. Instruct the patient to gently scrub only the lid margin, not
the conjunctiva or outer lid area, using warm water with a facecloth, a commercial eyelid scrub (e.g.,
Lid-Care), or a cotton swab dipped in a solution of baby shampoo diluted with warm water
3. Mechanical expression, performed by an ophthalmologist, may be necessary to decrease the amount
of irritating lipids within the glands. The patient may be instructed to perform firm massage of the lid
margins after applying warm compresses, to enhance secretion from the meibomian glands. One hand
holds the eyelid taut at the outer corner, while the index finger of the other hand presses along the lid
from the inner corner out. Alternatively, the patient may simply apply direct pressure to the lid if that is
more comfortable.
Lid hygiene may be required once or twice daily, immediately after initial diagnosis or during periods of
exacerbation, but may be reduced to twice a week once control has been achieved.6,23,25 This decision
should be made by the treating healthcare practitioner. Very few patients will be able to completely
discontinue a lid hygiene regimen.
If blepharitis persists despite treating with standard therapy, consider assessing whether the patient used a
lid hygiene product containing cocoamidopropyl betaine (CAPB). CAPB is a surfactant present in many
cosmetic and self-care products, including baby shampoo and eyelid scrub products, that is known to cause
contact dermatitis and eyelid dermatitis.26 Recalcitrant blepharitis has been associated with the use of
products containing CAPB.
Ailments—Herbal and Natural Health Products: Single Entity.
Advise patients to use topical nonprescription antibacterials for blepharitis only with medical advice.
Omega-3 fatty acids (e.g., flaxseed oil supplements), which have anti-inflammatory properties and may
enhance lubrication, may be useful in patients with tear deficiencies.21
Treatment of anterior blepharitis may include topical antistaphylococcal antibiotics, used after eyelid
cleansing.23,24 Antibacterial ointments, applied on the lid margins, are preferred to drops because of
increased contact time between the drug and tissues. Ointments that cover gram-positive organisms, such
as bacitracin and erythromycin, are applied 1–4 times per day for 1–2 weeks. If effective, treatment can be
reduced to once daily at bedtime for a further 4–8 weeks. Continue treatment for a month after all signs of
inflammation have subsided.
Short-term treatment with topical corticosteroids or corticosteroid/antibacterial combinations may be

necessary during exacerbations, or for severe inflammation and complications.23,24 For further information
on ophthalmic therapy, consult the Compendium of Therapeutic Choices: Red Eye.
In posterior blepharitis, patients may require systemic antibacterial therapy for several weeks or even
months, in addition to lid hygiene.23,24 Tetracyclines (Tetracycline, doxycycline or minocycline) are usually
the drugs of choice. Erythromycin is an alternative when tetracyclines are contraindicated (e.g., allergy or
during pregnancy). Azithromycin can be used as pulse therapy for the treatment of meibomian gland
dysfunction because of its long half-life.27,28 More information on antimicrobial therapy for blepharitis can
be found in Table 2.
.....
Table 1 provides a monitoring plan, which should be individualized.3,5,8,15,23
Table 1: Monitoring of Therapy for Eyelid Conditions

Eye Goals/Endpoint of
Condition Monitoring Therapy Actions
Hordeolum Patient: Daily Spontaneous drainage Requires assessment for
Healthcare within 48 h. further therapy if drainage
practitioner: After 48 does not occur within 48 h, if
h pain worsens or if there are
signs of infection.
Chalazion Patient: Daily Improvement should Requires assessment for

Healthcare begin within a few days. further therapy if the lesion is
practitioner: After 2–3 Complete resolution can large and/or painful or if
days take weeks to months. spontaneous drainage does
not occur.
For patients with blepharitis,
encourage regular lid
hygienea to prevent
chalazion recurrence.
Blepharitis Patient: Daily during Control inflammation and Encourage adherence with
exacerbation. Less discomfort. lid hygiene regimen.a Ensure
often when controlled Reduce the risk of severe, that patients cleanse only
Healthcare long-term complications. the margin of the eyelid and
practitioner: Each visit do not scratch the eyeball or
in chronic disease. conjunctiva.
Within 1 wk if patient Requires assessment for
requires anti-infective further therapy if new onset
therapy of blepharitis is suspected.
For exacerbations,
assessment required for
anti-infective or other
therapy.
a
See Blepharitis, Nonpharmacologic Therapy.
Drug Table
Table 2: Antimicrobials Used in the Treatment of Blepharitis21,27,28
Class Drug Dosage Adverse Effects Drug Comments Costa
Interactions
Tetracycline doxycycline 100 mg GI effects, yeast Products Not for $
generics daily overgrowth, containing use in
photosensitivity, aluminum, pregnancy.
acute renal calcium,
failure. magnesium
or iron may
impair the
absorption of
oral
tetracyclines.
Separate
doses by 2 h.
May also
interact with
warfarin,
retinoids,
digoxin,
antiepileptics,
penicillin.
Tetracycline minocycline 50–100 GI effects, yeast Products Not for $

generics mg daily overgrowth, containing use in
photosensitivity, aluminum, pregnancy.
acute renal calcium,
failure. magnesium
Also dizziness, or iron may
vertigo, impair the
abnormal absorption of
cutaneous oral
pigmentation. tetracyclines.
Separate
doses by 2 h.
May also
interact with
warfarin,
retinoids,
digoxin,
antiepileptics,
penicillin.
Tetracycline tetracycline 250 mg GI effects, yeast Products Not for $

QID overgrowth, containing use in
generics photosensitivity, aluminum, pregnancy.
acute renal calcium, Dose may
failure. magnesium be tapered
or iron may to 250–
impair the 500 mg
absorption of daily.
oral Take on an
tetracyclines. empty
Separate stomach, 1
doses by 2 h. h before or
May also 2 h after
interact with food or
warfarin, milk
retinoids, ingestion.
digoxin,
antiepileptics,
penicillin.
Macrolide erythromycin 250 mg GI effects: Avoid use May be $
Eryc, QID Nausea, with highest used
generics vomiting, risk QTc- cautiously
epigastric prolonging in
distress, agents, pregnancy.
diarrhea. QTc amiodarone,
interval fluconazole,
prolongation. lovastatin,
pimozide,
simvastatin.
Moderate
CYP3A4
inhibitor,
concurrent
use with
CYP3A4
substrates
may result in
increased
effects of the
substrate.
Macrolide azithromycin 1g GI effects: Avoid use May be $$$/week

Zithromax, weekly Nausea, with highest used
generics or 500 vomiting, risk QTc- cautiously
mg daily epigastric prolonging in
for 3 distress, agents, pregnancy.
days, diarrhea. QTc amiodarone,
repeated interval fluconazole,
weekly prolongation. lovastatin,
GI effects not pimozide,
as common as simvastatin.
with Not expected
erythromycin. to inhibit
CYP3A4.
a Cost per day unless otherwise specified; includes drug cost only.

Legend: $ <$1 $$ $1–5 $$$ $5–10
Resource Tips
Mayo Clinic. Blepharitis. Available from: www.mayoclinic.org/diseases-
conditions/blepharitis/basics/definition/con-20024605.
National Eye Institute. Facts about blepharitis. Available from: nei.nih.gov/health/blepharitis/blepharitis.
WedMD. Styes and chalazia—topic overview. Available from: www.webmd.com/eye-health/tc/styes-and-

chalazia-topic-overview.
Suggested Readings
American Academy of Ophthalmology. Blepharitis PPP-2013. Available from: www.aao.org/preferred-
practice-pattern/blepharitis-ppp--2013.
Carlisle RT, Digiovanni J. Differential diagnosis of the swollen red eyelid. Am Fam Physician 2015;92:106-12.
Gupta A, Stacey S, Amissah-Arthur KN. Eyelid lumps and lesions. BMJ 2014;348:g3029.
Merck manual: professional version. Chalazion and hordeolum (stye). Available from:
www.merckmanuals.com/professional/eye-disorders/eyelid-and-lacrimal-disorders/chalazion-and-
hordeolum-stye.
Vagefi MR, Sullivan JH, Corrêa ZM et al. Lids & lacrimal apparatus. In: Riordan-Eva P, Cunningham ET, eds.
Vaughan & Asbury's general ophthalmology. 18th ed. New York: McGraw-Hill Medical; 2011.
References
1. Rubin S, Hallagan L. Lids, lacrimals, and lashes. Emerg Med Clin North Am 1995;13:631-48.
2. Sullivan JH, Shetlar DJ, Whitcher JP. Lids, lacrimal apparatus, & tears. In: Riordan-Eva P, Whitcher J,
eds. Vaughan & Asbury's general ophthalmology. 17th ed. New York: Lange Medical Books/McGraw-
Hill Medical; 2008.
3. Lederman C, Miller M. Hordeola and chalazia. Pediatr Rev 1999;20:283-4.
4. Kanski JJ. Clinical ophthalmology: a systematic approach. 4th ed. Oxford: Butterworth-Heinemann;
1999.
5. Shields SR. Managing eye disease in primary care. Part 2. How to recognize and treat common eye
problems. Postgrad Med 2000;108:83-6, 91-6.
6. Raskin EM, Speaker MG, Laibson PR. Blepharitis. Infect Dis Clin North Am 1992;6:777-87.
7. Thielen TL, Castle SS, Terry JE. Anterior ocular infections: an overview of pathophysiology and
treatment. Ann Pharmacother 2000;34:235-46.
8. Mueller JB, McStay CM. Ocular infection and inflammation. Emerg Med Clin North Am 2008;26:57-72.
9. Jones YJ, Georgesuc D, McCann JD et al. Microwave warm compress burns. Ophthal Plast Reconstr
Surg 2010;26:219.
10. Freedman HL, Preston KL. Heat retention in varieties of warm compresses: a comparison between
warm soaks, hard-boiled eggs and the re-heater. Ophthalmic Surg 1989;20:846-8.
11. McMonnies CW, Korb DR, Blackie CA. The role of heat in rubbing and massage-related corneal
deformation. Cont Lens Anterior Eye 2012;35:148-54.
12. Lam AK, Lam CH. Effect of warm compress therapy from hard-boiled eggs on corneal shape. Cornea
2007;26:163-7.
13. Deibel JP, Cowling K. Ocular inflammation and infection. Emerg Med Clin N Am 2013;31:387-97.
14. Lindsley K, Nichols JJ, Dickersin K. Interventions for acute internal hordeolum. Cochrane Database
Syst Rev 2013;(4):CD007742.
15. Baum J. Infections of the eye. Clin Infect Dis 1995;21:479-86.
16. Gilchrist H, Lee G. Management of chalazia in general practice. Aust Fam Physician 2009;38:311-4.
17. Nemet AY, Vinker S, Kaiserman I. Associated morbidity of chalazion. Cornea 2011;30:1376-81.
18. Arbabi EM, Kelly RJ, Carrim ZI. Chalazion. BMJ 2012;341:c4044.
19. Cottrell DG, Bosanquet RC, Fawcett IM. Chalazions: the frequency of spontaneous resolution. Br Med
J (Clin Res Ed) 1983;287:1595.
20. Smythe D, Hurwitz JJ, Tayfour F. The management of chalazion: a survey of Ontario
ophthalmologists. Can J Ophthalmol 1990;25:252-5.
21. Bernardes TF, Bonfioli AA. Blepharitis. Semin Ophthalmol 2010;25:79-83.
22. Nemet AY, Vinker S, Kaiserman I. Associated morbidity of blepharitis. Ophthalmology 2011;118:1062-
8.
23. Jackson WB. Blepharitis: current strategies for diagnosis and management. Can J Ophthalmol
2008;43:170-9.
24. Medscape from WebMD. Lowery RS. Adult blepharitis. Available from: emedicine.medscape.com.
Accessed April 7, 2016. Registration required.
25. Morrow GL, Abbott RL. Conjunctivitis. Am Fam Physician 1998;57:735-46.
26. Welling JD, Mauger TF, Schoenfield LR et al. Chronic eyelid dermatitis secondary to cocamidopropyl
betaine allergy in a patient using baby shampoo eyelid scrubs. JAMA Ophthalmol 2014;132:357-9.
Assessment of Patients with Hearing Loss, Ear Pain and Ear Drainage

Signs and Symptoms

Ear symptoms may occur in many conditions. Table 1 describes signs and symptoms associated with
various otic conditions and Figure 1 provides an algorithm for patient assessment. Signs and symptoms
commonly associated with ear disease include ear pain, ear drainage, tinnitus, vertigo, dizziness and hearing
loss. Assessment should include determining the patient’s age, location and characteristics of the pain, and
the presence or absence of pruritus, hearing loss, discharge from the ear, or any aggravating factors
associated with the symptoms.
Table 1: Signs and Symptoms Associated with Various Ear Conditions

Hearing
Condition Pain Pruritus Discharge Comments
Loss
Acute Yes Sometimes Frequent Sometimes Associated with

bacterial (acute excessive moisture,
otitis externa onset) trauma to EAC, attempts
to scratch or remove
wax from EAC.
Pain with chewing,
movement of auricle.
Barotrauma Yes No Yes if TM Yes Associated with air

ruptures travel (descent) and
diving.
Tinnitus and vertigo may
also be present.
Eczematous Sometimes Yes Sometimes Sometimes Characteristic features

otitis externa (crusting, of underlying
oozing) dermatologic condition
may be present (e.g.,
psoriatic plaques;
erythema and scaling
with atopic dermatitis).
May become
secondarily infected.
Foreign body Yes Sometimes If becomes Yes Fullness and pressure in

infected the ear.
Impacted Rarely Frequent Rarely Yes May be described as

earwax unless unless (gradual) fullness or pressure.
infected infected
Hearing
Condition Pain Pruritus Discharge Comments
Loss
Otitis media Yes No Yes if TM Sometimes Primarily in children.

(abrupt ruptures Pain relieved with
onset) rupture of TM.
Commonly preceded by
viral URTI.
Ruptured Yes No Yes Yes May be associated with

tympanic (sudden, (abrupt) acute otitis media,
membrane sharp) barotrauma and other
conditions.
Abbreviations: EAC = external auditory canal; TM = tympanic membrane; URTI = upper respiratory tract infection
Ear Pain (Otalgia)
Otalgia is usually associated with inflammation of the external or middle ear, but pain may be referred to
the ear from other sites such as the teeth, temporomandibular joint, pharynx or sinuses.1,2,3 If pain lasts
more than 2–3 days, refer the patient for medical evaluation.
Ear Drainage (Otorrhea)
Otorrhea may be caused by a simple scratch in the ear or by serious medical conditions. Otorrhea is
often a sign of otitis externa, otitis media with perforation of the tympanic membrane or drainage from
the middle ear from tympanostomy tubes.3,4 Bloody drainage can occur with several conditions,
including trauma, neoplasm and foreign bodies. Clear drainage may be from the middle ear or a
cerebrospinal fluid leak. Drainage resulting from mild otitis externa (e.g., eczematous) may be self-
treated; however, unless this is specifically identified as the cause, the patient should be referred for
assessment and treatment.
Tinnitus, Vertigo and Dizziness
These symptoms are discussed in detail in Tinnitus and in Vertigo and Dizziness.
Hearing Loss
Hearing loss is classified as either conductive or sensorineural.5,6,7 Conductive hearing loss occurs
when sound is prevented from gaining access to the inner ear, and may result from diseases of the
external or middle ear. Examples include otitis externa, impacted earwax, upper respiratory tract
infections, otitis media, foreign objects or water trapped in the ear and tumors. Rupture of the tympanic
membrane due to acute otitis media or trauma also produces hearing loss. Sensorineural hearing loss
involves the inner ear or cochlea, the auditory nerve or a central nerve lesion. These conditions are not
managed by self-care. Unless hearing loss is identified as due to impacted earwax or an upper
respiratory tract infection, all patients with hearing loss should be referred to an appropriate healthcare
practitioner for assessment.
Drug-induced Ototoxicity
Hearing loss, tinnitus and vertigo may be drug-induced. It is important to review a patient's medication
profile to ensure that symptoms are not due to drug-induced ototoxicity. Many drugs have been
associated with ototoxicity, sometimes only as a single case report.8 Drugs more commonly associated
with ototoxicity are found in Table 2. This is not an exhaustive list; a more comprehensive list can be
found in Cianfrone et al (see Suggested Readings).
Table 2: Drugs Associated with Ototoxicity

Type of Hearing
Drug Reversibility Risk Factors Comments
Loss
Aminoglycosides9,10,11,12 Cochlear Irreversible Possibly related to Discontinuation

(sensorineural total dose at first sign
(amikacin, gentamicin, hearing loss and administered. may limit
neomycin, streptomycin, tinnitus) and damage.
tobramycin) Not correlated well
vestibular with serum Audiology
(unrelenting concentrations. monitoring
dizziness with recommended
occasional Renal
insufficiency. by some as
nausea and initial hearing
vomiting). Age >60 y. loss may be
Previous higher
sensorineural frequency and
hearing loss, noise not noticed by
exposure, patient.
concurrent use of Vestibular
other ototoxic testing (e.g.,
drugs. dynamic
Duration of illegible E or
treatment >10 DIE)
days. recommended
by some.
Risk no greater
with once-daily
dosing
compared with
multiple daily
doses.
ASA13,14 Tinnitus. Hearing loss Correlated with

Decreased usually serum salicylate
acoustic recovers 24–72 levels and higher
sensitivity and h after doses.
altered sound discontinuation. Elderly patients.
perception.
Type of Hearing
Loss
Cisplatin15 Sensorineural Usually Renal Dose-related,

hearing loss. permanent. insufficiency, pre- cumulative.
Some patients existing hearing
exhibit tinnitus. loss and noise
exposure.
Bilateral.
Increased risk with
renal insufficiency,
high serum drug
levels, age >60 y,
previous
sensorineural
hearing loss, noise
exposure,
concurrent use of
other ototoxic
drugs, duration of
treatment >10
days.
Loop diuretics13,16,17 Hearing loss and Usually Renal failure.

tinnitus. transient. Generally with
(bumetanide, ethacrynic
acid, furosemide) Permanent high-dose iv use.
hearing loss Concurrent use of
also reported. ototoxic drugs.
Hypoalbuminemia.
Liver disease.
Heart failure.
Furosemide
infusion rates >4
mg/min.
Macrolides18,19,20,21,22 Sensorineural Usually Renal dysfunction. Recovery

with tinnitus. reversible. Hepatic begins as soon
(azithromycin, as drug is
clarithromycin, Bilateral. Irreversible dysfunction.
hearing loss discontinued.
erythromycin) Female sex.
and tinnitus
reported at low Erythromycin dose
doses as well. >4 g/day.
Phosphodiesterase type Sudden hearing Usually Unknown.

5 inhibitors23 loss sometimes unilateral.
accompanied by Reversible in
(sildenafil, tadalafil, tinnitus and
vardenafil) one-third of
dizziness. cases.
Type of Hearing
Loss
Quinine13,14 High frequency Reversible. Initiation of high- Cinchonism:

sensorineural Bilateral. dose therapy or headache,
hearing loss. chronic lower nausea, vertigo,
Vestibular dose therapy. tinnitus,
toxicity also deafness,
seen. blindness and
dysphoria.
Tetracyclines Vestibular Generally self- More common in Occurs at usual

symptoms such limiting. women. oral doses and
(doxycycline,24 as usually
minocycline25,26) lightheadedness, disappears
loss of balance, within 2 days.
dizziness and
tinnitus.
Miscellaneous Conditions Affecting the Ear

Conditions affecting the auricle such as dermatitis (Atopic, Contact, and Stasis Dermatitis), infections
(Bacterial Skin Infections: Impetigo, Furuncles and Carbuncles, Fungal Skin Infections), burns (Burns),
frostbite (Frostbite) and lacerations (Minor Cuts and Wounds), are amenable to self-treatment if not severe.
More detailed assessment by an appropriate healthcare provider is required if these are not easily
distinguishable by history and appearance.
Algorithms
1,2,3,5,6,7
Figure 1: Assessment of Patients with Ear Complaints
Pruritis
tenderness
debris
fullness
itching
irritation
a Ear conditions often present as a constellation of symptoms (Table 1). The predominant symptom often varies
between individuals. For this reason, more than one path of this algorithm may apply to a particular case.
b
See Complications Affecting the Ear: Ear Piercing, Foreign Bodies and Barotrauma.
c See Otitis Media and Otitis Externa.
d
See Viral Rhinitis, Influenza, Sinusitis and Pharyngitis.
e See Impacted Earwax.
f
See Tinnitus.
Abbreviations: EAC = external auditory canal; TM = tympanic membrane; URTI = upper respiratory tract infection
Suggested Readings
Cianfrone G, Pentangelo D, Cianfrone E et al. Pharmacological drugs inducing ototoxicity, vestibular
Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician 2008;77:621-8.
References
References
1. Stallard TC. Emergency disorders of the ear, nose, sinuses, oropharynx & mouth. In: Stone C,
Humphries RL, eds. Current diagnosis & treatment emergency medicine. 7th ed. New York: McGraw-
Hill; 2011. Available from: accessmedicine.mhmedical.com. Accessed August 30, 2015.
2. Shah RK, Blevins NH. Otalgia. Otolaryngol Clin North Am 2003;36:1137-51.
3. Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician 2008;77:621-8.
4. Pankhania M. Otorrhoea. BMJ 2011;342:d2299.
5. Lustig LR, Schindler JS. Ear, nose and throat disorders. In: Papadakis MA, McPhee SJ, Rabow MW,
eds. Current medical diagnosis & treatment 2015. New York: McGraw Hill. Available from:
accessmedicine.mhmedical.com. Accessed August 30, 2015. Subscription required.
6. Friedman NR, Scholes MA, Yoon PJ. Ear, nose, and throat. In: Hay WW, Levin MJ, Deterding RR et al.,
eds. Current diagnosis and treatment: pediatrics. 22nd ed. New York: McGraw Hill; 2013. Available
from: accessmedicine.mhmedical.com. Accessed August 30, 2015. Subscription required.
7. Lalwani AK. Disorders of hearing. In: Kasper D, Fauci A, Hauser S et al., eds. Harrison's principles of
internal medicine. 19th ed. New York: McGraw-Hill; 2015. Available from:
accessmedicine.mhmedical.com. Accessed August 30, 2015. Subscription required.
8. Seligmann H, Podoshin L, Ben-David J et al. Drug-induced tinnitus and other hearing disorders. Drug
Saf 1996;14:198-212.
9. Rizzi MD, Hirose K. Aminoglycoside ototoxicity. Curr Opin Otolaryngol Head Neck Surg 2007;15:352-7.
10. Ariano RE, Zelenitsky SA, Kassum DA. Aminoglycoside-induced vestibular injury: maintaining a
sense of balance. Ann Pharmacother 2008;42:1282-9.
11. Barza M, Ioannidis JP, Cappelleri JC et al. Single or multiple daily doses of aminoglycosides: a meta-
analysis. BMJ 1996;312:338-45.
12. Palmay L, Walker SA, Walker SE et al. Symptom reporting compared with audiometry for the
detection of cochleotoxicity in patients on long-term aminoglycoside therapy. Ann Pharmacother
2011;45:590-5.
13. Yorgason JG, Fayad JN, Kalinec F. Understanding drug ototoxicity: molecular insights for prevention
and clinical management. Expert Opin Drug Saf 2006;5:383-99.
14. Jung TT, Rhee CK, Lee CS et al. Ototoxicity of salicylate, nonsteroidal antiinflammatory drugs, and
quinine. Otolaryngol Clin North Am 1993;26:791-810.
15. Rybak LP. Mechanisms of cisplatin ototoxicity and progress in otoprotection. Curr Opin Otolaryngol
Head Neck Surg 2007;15:364-9.
16. Ikeda K, Oshima T, Hidaka H et al. Molecular and clinical implications of loop diuretic ototoxicity.
Hear Res 1997;107:1-8.
17. Baldwin KA, Budzinski CE, Shapiro CJ. Acute sensorineural hearing loss: furosemide ototoxicity
revisited. Hosp Pharm 2008;43:982-7,1007.
18. Principi N, Esposito S. Comparative tolerability of erythromycin and newer macrolide antibacterials
in paediatric patients. Drug Saf 1999;20:25-41.
19. Whitener CJ, Parker JE, Lapp NL. Erythromycin ototoxicity: a call to heighten recognition. South Med
J 1991;84:1214-6.
20. Ress BD, Gross EM. Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity. A
case report. Ann Otol Rhinol Laryngol 2000;109:435-7.
21. Hajiioannou JK, Florou V, Kousoulis P, et al. Clarithromycin induced reversible sensorineural hearing
loss. B-ENT. 2011;7(2):127-30.
22. Coulston J, Balaratnam N. Irreversible sensorineural hearing loss due to clarithromycin. Postgrad
Med J. 2005 Jan;81(951):58-9.
23. Maddox PT, Saunders J, Chandrasekhar SS. Sudden hearing loss from PDE-5 inhibitors: a possible
cellular stress etiology. Laryngoscope 2009;119:1586-9.
24. Segelnick SL, Weinberg MA. Doxycycline-induced dizziness in dental patient. Case report. N Y State
Dent J 2010;76:28-32.
25. Jacobson JA, Daniel B. Vestibular reactions associated with minocycline. Antimicrob Agents
Chemother 1975;8:453-6.
26. Fanning WL, Gump DW, Sofferman RA. Side effects of minocycline: a double-blind study. Antimicrob
Agents Chemother 1977;11:712-7.
Complications Affecting the Ear: Ear Piercing, Foreign Bodies and Barotrauma

Complications of Ear Piercing

Ear piercing complications are common (up to 35% of patients) and most frequently include infection and allergic reactions to
metals.1,2 Mild redness, swelling and crusting is part of the normal course of healing post-piercing. Healing typically takes 6–
8 weeks or longer depending on what part of the ear is pierced. To prevent infection, the piercing site should be washed twice
daily with soap and water. Alcohol is no longer recommended because of excessive drying. If a mild bacterial infection
develops secondary to piercing, it can be managed with local therapy (cleansing, warm compresses and topical antibiotics)
without removing the earring. If the inflammation or swelling is significant, the earring may need to be removed in which case
a ring can be made from a nylon suture material or a 20-gauge Teflon catheter with silicone tubing (available from surgical
supply manufacturer) and inserted into the hole to keep it open.1 High ear piercings can produce infections of the cartilage
which are much more serious.1,2,3 These patients require further assessment and management. Allergic dermatitis is
managed by avoidance of the inciting compound (nickel or gold) and may include short-term use of a mild to moderate topical
corticosteroid, such as hydrocortisone 0.5% or 1% or clobetasone butyrate 0.05%. See Ear Piercing—What You Need to Know
for recommendations to reduce the risk of ear piercing complications and information on caring for the ears after piercing.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Skin Care
Products: Dermatitis and Dry Skin.
Foreign Bodies
Foreign bodies in the ear canal occur more frequently in children than adults.4,5 Often the patient (or witness in the case of a
child) will give a history of a foreign object entering the ear. Patients experience pain, which may be dull or severe, a feeling of
fullness or pressure in the ear and loss of hearing. Foreign objects should always be removed by a healthcare practitioner. If
patients attempt to remove objects by syringing, especially if they are organic (e.g., beans, peas, insects), the object may swell
when moistened and occlude the canal. If the objects are sharp they may scratch the canal or perforate the tympanic
membrane. Cotton-tipped applicators may push the foreign object further into the canal. Insects are particularly annoying
because of their movement. Provided the tympanic membrane is not perforated, insects may be drowned at home by using a
dropper to fill the ear canal with mineral oil, olive oil or baby oil before removal by the healthcare practitioner.
Barotrauma
Otic barotrauma, also referred to as aerotitis media, occurs when an individual cannot equalize the pressure gradient between
the middle ear and the atmosphere.6,7,8 This occurs during air travel (descent) and underwater diving (descent). The
eustachian tube closes, causing a painful pressure change in the middle ear and extravasation of fluid and blood into the
middle ear space. Tympanic membrane perforation may result. The symptoms are a sensation of ear blockage followed by
ear pain, tinnitus, vertigo and transient conductive hearing loss. With diving, tympanic membrane rupture may result in severe
vertigo due to cold water entering the middle ear. This may become life threatening due to disorientation.9 The condition may
last 2 or 3 days and usually resolves spontaneously. More severe injury can occur with deep sea dives. Occasionally, surgery
may be required. Treatment includes analgesics for pain, oral10 or topical decongestants6 to encourage opening of the
eustachian tube and attempts to auto-inflate using the Valsalva manoeuvre (forced expiration keeping the mouth tightly
closed and the nostrils pinched) or the Toynbee manoeuvre (holding the nose and swallowing hard with the mouth closed).
The Valsalva manoeuvre may cause syncope or cardiac arrhythmia and should not be recommended to patients with cardiac
disease.
The Divers Alert Network (DAN) has guidelines for flying after recreational diving. They suggest waiting 12 hours after a single
recreational dive. For multiple dives in one day or multiple dives over multiple days, DAN suggests waiting at least 18 hours
before flying. For dives requiring decompression stops, a wait time of at least 18 hours is recommended although DAN states
there is little evidence to support this recommendation.11 More information on recreational diving can be found on the DAN
website at www.diversalertnetwork.org.
If symptoms of barotrauma do not subside in 24 hours, or if bloody fluid drains from the ear indicating a ruptured tympanic
membrane, refer the patient for further assessment and management.
As mentioned above, poor functioning of the eustachian tube can result in failure of pressure equilibration during descent
while flying or diving. This may be due to congenital and anatomic conditions, but upper respiratory tract infections,
eustachian tube edema resulting from allergies, chronic middle ear disease and nasal chamber edema during pregnancy also
produce eustachian tube dysfunction. Flying or diving should be postponed in these individuals if possible; in some cases
diving may be contraindicated (e.g., if the tympanic membrane is perforated).12 The eustachian tube also does not function
normally while an individual is asleep.
Beginning early in the descent while flying, individuals should swallow, yawn and auto-inflate frequently. They should ensure
they are awakened prior to descent. Children can be given gum to chew or candy to suck; small children can be breastfed or
given a bottle during descent to reduce discomfort. When diving, various techniques are used during descent, such as the
Valsalva manoeuvre, yawning, swallowing or moving the jaw from side to side.9
Nasal sprays and oral decongestants are often recommended to prevent barotrauma. In adults, pseudoephedrine 120 mg
sustained-release formulation taken 30 minutes before flying has been shown to reduce pain, blockage and hearing loss in
individuals with a history of ear discomfort,13,14 but oxymetazoline nasal spray is not better than placebo.13 Efficacy has not
been demonstrated in children ≤6 years and Health Canada advises against their use in this age group;15 therefore,
decongestants should not be used in this population.16 The most appropriate recommendation is for 60 mg (regular-release)
or 120 mg (sustained-release) of oral pseudoephedrine in adults. Administration 30 minutes prior to takeoff is appropriate for
short flights under 4 hours. Because it is the descent that causes problems, on long international flights, pseudoephedrine
should be taken 30–60 minutes prior to the anticipated arrival time. Drowsiness was the only adverse effect reported in
clinical trials specific to barotrauma.14 Data on insomnia were not presented. The product selected should have sufficient
duration of action to match the length of the flight.
Pseudoephedrine 60 mg taken 30 minutes before diving decreased the incidence and severity of middle ear barotrauma in
first-time divers.17 For contraindications and precautions, see Table 1.
Products: Internal Analgesic and Antipyretics; Cough, Cold and Allergy Products.
Drug Table
Table 1: Drugs Used in the Management and Prevention of Barotrauma
Decongestants, pseudoephedrine Adults and Mild CNS Beta-blockers: Caution in $$

oral children stimulation Antihypertensive patients with
Eltor 120, ≥12 y: 60 (nervousness, effects may be heart disease,
Sudafed mg Q4– excitability, reduced. high blood
Decongestant 6H po restlessness, MAOIs and ergot pressure,
12 Hour, Sustained- dizziness, derivatives may hyperthyroidism,
generics release: weakness, enhance the diabetes, angle-
120 mg insomnia). hypertensive closure
Q12H po Peripheral effect of glaucoma or
Maximum: vasoconstriction. pseudoephedrine. prostatic
240 mg Tachycardia or Concurrent use enlargement.
per day palpitation may and use within 14 Onset of action
occur. Blood days of 30 min.
Children pressure may be
6–11 y: 30 discontinuation
increased in of MAOIs is
mg Q4– hypertensive
6H po contraindicated.
patients. May
Maximum: adversely affect
120 mg blood sugar
per day control in
diabetics.
a
Cost of 12 tablets; includes drug cost only.
Legend: $ < $3 $$ $3–6
Suggested Readings
Csortan E, Jones J, Haan M et al. Efficacy of pseudoephedrine for the prevention of barotrauma during air travel. Ann Emerg
Med 1994;23:1324-7.
Holbrook J, Minocha J, Laumann A. Body piercing: complications and prevention of health risks. Am J Clin Dermatol
2012;13:1-17.
Meltzer DI. Complications of body piercing. Am Fam Physician 2005;72:2029-34.
Newbegin C, Ell S. Ear barotrauma after flying and diving. Practitioner 2000;244:96-9, 101-2, 105.
References
1. Meltzer DI. Complications of body piercing. Am Fam Physician 2005;72:2029-34.

2. Holbrook J, Minocha J, Laumann A. Body piercing: complications and prevention of health risks. Am J Clin Dermatol
2012;13:1-17.
3. Manca DP, Levy M, Tariq K. Case report: infected ear cartilage piercing. Can Fam Physician 2006;52:974-5.
4. Ely JW, Hansen MR, Clark EC. Diagnosis of ear pain. Am Fam Physician 2008;77:621-8.
5. Friedman NR, Scholes MA, Yoon PJ. Ear, nose, and throat. In: Hay WW, Levin MJ, Sondheimer JM et al. Current pediatric
diagnosis and treatment. 22nd ed. New York: McGraw-Hill; 2013. Available from: accessmedicine.mhmedical.com.
Accessed August 31, 2015. Subscription required.
6. DeGorordo A, Vallejo-Manzur F, Chanin K et al. Diving emergencies. Resuscitation 2003;59:171-80.
7. Wright T. Middle-ear pain and trauma during air travel. BMJ Clin Evid 2015;pii:0501.
8. Lynch JH, Deaton TG. Barotrauma with extreme pressures in sport: from scuba to skydiving. Curr Sports Med Rep
2014;13:107-12.
9. Hamilton-Farrell M, Bhattacharyya A. Barotrauma. Injury 2004;35:359-70.
10. Mirza S, Richardson H. Otic barotrauma from air travel. J Laryngol Otol 2005;119:366-70.
11. Sheffield, P, Vann R; Divers Alert Network. Flying after recreational diving: workshop proceedings, May 2, 2002. Durham:
DAN; 2004. Available from: www.diversalertnetwork.org/files/FADWkshpBook_web.pdf.
12. McMullin A. Scuba diving: what you and your patients need to know. Cleve Clin J Med 2006;73:711-2, 714, 716.
13. Jones JS, Sheffield W, White LJ et al. A double-blind comparison between oral pseudoephedrine and topical
oxymetazoline in the prevention of barotrauma during air travel. Am J Emerg Med 1998;16:262-4.
14. Csortan E, Jones J, Haan M et al. Efficacy of pseudoephedrine for the prevention of barotrauma during air travel. Ann
Emerg Med 1994;23:1324-7.
15. Government of Canada. Concerns about children's medication. Date modified: 2015-03-26. Available from:
www.healthycanadians.gc.ca.
16. Buchanan BJ, Hoagland J, Fischer PR. Pseudoephedrine and air travel-associated ear pain in children. Arch Pediatr
Adolesc Med 1999;153:466-8.
17. Brown M, Jones J, Krohmer J. Pseudoephedrine for the prevention of barotitis media: a controlled clinical trial in
underwater divers. Ann Emerg Med 1992;21:849-52.

Ear Piercing
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients. Once printed there
is no quarantee the information is up-to-date. [Printed on: 07-30-2017 12:59 PM]
Ear Piercing—What You Need to Know
Recommendations to reduce the risk of ear piercing problems:
Ear piercing should be done only by individuals who have proper training. All piercing equipment must be sterile.
There is a higher rate of infection and other problems for people who pierce their ears at home.
Do not pierce the ears of children <5 years of age. The earrings may get caught during play and injure the child’s
ears. Also it is more difficult to keep a child’s piercings cleaned properly.
Do not have your ears pierced if you have any of the following health problems: valvular heart disease, diabetes,
glomerulonephritis or a history of rheumatic fever. The risk of infection is higher and more serious for these
individuals.
Do not have your ears pierced if you have had problems with scarring in the past, such as thick, raised scars
(keloid formation).
Avoid using earrings that contain nickel or gold in newly pierced ears. This will help to reduce the risk of an
allergic skin reaction (dermatitis).
Be sure that the studs are made in a single piece from surgical grade stainless steel.
Before the ears are pierced: Clean the earlobes with alcohol or chlorhexidine soap. Allow the lobes to dry
completely.
Care of the ears following piercing:
Wash the piercing twice daily with soap and water for the first 6 weeks. Be sure to get between the stud and
skin on the front, and between the earring back and skin on the back of the lobe.
Examine the ears carefully after they are pierced. Watch for redness, swelling or rash. Feel the lobes for small
lumps (which could be cysts or nodules). See a doctor right away if you have any of these problems.
Do not turn or twist the earrings except when cleaning; this increases the risk of infection. Leave studs in place
for 6 weeks.
When you wash your hair, make sure you rinse all shampoo from the ear area. Avoid using hair spray and
perfume until the lobes are well healed.
When the earlobes are completely healed (at least 6 weeks), you can take out the studs. Wet the earlobes with
water and soap to make it easier to remove the studs.
Once earlobes are healed, wash daily with soap and water, just as you would wash your face.
Always wash earrings with soap and water before putting them in your earlobes.
Impacted Earwax

Pathophysiology
The skin lining the lateral two-thirds of the external auditory canal (EAC) contains hair follicles, ceruminous
glands (producing cerumen) and sebaceous glands (producing sebum).1,2,3 Earwax is composed of
secretions from these glands mixed with exfoliated squamous epithelium, sweat and foreign substances
such as dirt, hairspray and shampoo. Earwax, rather than cerumen, is the more correct term to use although
the two are often used interchangeably.4 Earwax lubricates and protects the ear; it is water repellent,
preventing maceration of the EAC, and is bacteriostatic. It is normally secreted in small amounts and moves
out of the ear through the action of cilia, talking and chewing. Factors that disrupt the normal migration of
earwax to the outer EAC increase the risk of impaction (see Table 1).
Accumulation of earwax may:1,3,5,6
Prevent visualization of the tympanic membrane (required when attempting to diagnose middle ear
conditions)
Cause impaction of wax
Produce hearing loss
Produce ear discomfort (sensation of fullness in the ear, or pruritis), ear pain, vertigo or tinnitus
Produce chronic cough
Contribute to infection by impairing the natural cleansing mechanism of the ear.
Table 1: Risk Factors for Earwax Impaction

Bony growths in the canal (osteophyte or osteoma)
Hearing aids and ear plug–type hearing protectors
History of previous impaction
Numerous ear canal hairs
Older age: ceruminous glands atrophy, creating drier cerumen that is more difficult to expel from
the ear
Use of cotton-tipped applicators
Goals of Therapy
Relieve symptoms
Allow visualization of tympanic membrane
Avoid damage to the EAC
Prevent infection
Prevent recurrence
Patient Assessment
Figure 1 illustrates the assessment pathway for a patient with suspected earwax impaction. Ideally, earwax
impaction is diagnosed by direct visualization with an otoscope.
Question the patient regarding the common symptoms of earwax impaction (sensation of fullness in the ear,
hearing loss and discomfort) and modifiable risk factors for impaction. There is often a history of attempted
removal of wax with cotton-tipped swabs or other foreign objects, which have actually pushed the wax
further into the ear and exacerbated symptoms. If there is discharge from the ear (pus or blood), coexisting
otitis externa or injury of the EAC may be present (see Otitis Media and Otitis Externa).
Referral for assessment and further treatment should be considered if:1

the ear has been injured
the tympanic membrane is perforated
there is a history of recent ear surgery
the patient has tympanostomy tubes
the patient has chronic otitis media
there is drainage from the ear, hearing loss, tinnitus or dizziness
the patient is a child
the patient has congenital or anatomical abnormalities. tinnitus-A sound in one ear or both
ears, such as buzzing, ringing, or
whistling
Prevention
The ear is usually self-cleaning. The external opening can be cleaned using a washcloth over the index
finger. Discourage attempts at removing earwax with cotton-tipped applicators, hair pins, matches,
fingernails and other objects. This may cause damage to the EAC and push wax farther into the canal,
causing impaction.
Instillation of olive oil, light mineral oil, hydrogen peroxide, glycerin or sodium bicarbonate are sometimes
recommended in individuals prone to earwax impaction as preventive therapy although there is no evidence
to support this effect. When used, a few drops of the agent is instilled into the ear or ears daily to twice
weekly.
Since the ear is generally self-cleaning, products or techniques to aid in earwax removal should be
recommended only when required (for example, when there is a need to see the tympanic membrane) or for
symptomatic relief. Discourage use by the patient to simply “keep the ears clean.”
A common method used to remove earwax is syringing the ear with water at body temperature, with or
without prior instillation of eardrops to soften the wax. Self-irrigation with bulb syringes can reduce the
demand for ear irrigation by healthcare practitioners and has been shown to be safe.7,8 Suggest assistance
from a caregiver as it may be difficult to perform the procedure on oneself. See Impacted Earwax—What You
Need to Know for steps outlining proper syringing technique.
Syringing is contraindicated if the tympanic membrane is perforated or has been perforated in the past,
infection is present, tympanostomy tubes are present, there is a history of ear surgery, the patient is a young
child who is uncooperative, or the affected ear is the patient's only hearing ear.1,9
Complications of syringing include failure to remove wax, pain or discomfort, vertigo, otitis media or otitis
externa, damage to the EAC and perforation of the tympanic membrane.1,5,9,10,11 Major complications occur
in approximately 1 in 1000 ears.11
Wax can also be manually removed with a curette, forceps or suction by a healthcare practitioner with the
appropriate training.1,3
A number of agents are purported to enhance removal of wax from the ear (see Table 2). These products
are instilled for the required period of time, after which the wax is allowed to be expelled naturally or the ear
syringed to remove the softened wax. Few studies exist to provide evidence of their effectiveness. Studies
comparing the effectiveness of various agents with each other or with syringing are of poor quality, making
it difficult to recommend one method over another.
Water-based ceruminolytics (see Table 2) and carbamide peroxide expand and loosen or dissolve wax plugs
while oil-based products simply lubricate the EAC and wax plug.3,4,12 In vitro data suggest oil-based
products (olive oil and urea hydrogen peroxide 5% in glycerol) are not effective in disintegrating cerumen.13
No earwax-softening agent has been demonstrated to be superior to others. Water or saline appears to be
as effective as sodium bicarbonate,14 chlorbutol,14 docusate sodium,14,15 or carbamide peroxide12,16 in
facilitating earwax removal with or without syringing.5 [Evidence: SORT B] A single instillation of any of
these agents into the ear canal for 15 minutes followed by syringing is as effective as using oil in the canal
for 3 nights followed by syringing.5,12,17 [Evidence: SORT B] Instillation of oil is commonly recommended by
healthcare practitioners; however, use of a non-oil-based earwax-softening agent followed by syringing is
often more convenient for the patient and offers more immediate relief of symptoms.
Commercially prepared otic products are available in a dropper bottle. If household products such as olive
oil are chosen, the patient should purchase a dropper and instil the substance in a manner similar to other
ear drops. “Home remedies” such as dilutions of hydrogen peroxide or solutions of sodium bicarbonate
should be freshly prepared and used immediately (see Table 2).
For comparative ingredients of nonprescription products, consult the Compendium of Products For Minor
Ailments—Otic Products.
Ceruminolytics should not be used if the tympanic membrane is not intact or if tympanostomy tubes are
present.
Ear candling is a procedure that has been claimed to remove earwax by creating a vacuum or negative
pressure within the ear canal. Studies have disproven the claims and have shown it may cause serious
injury.18,19 Risks associated with ear candling include burns, occlusion from candle wax, temporary loss of
hearing, punctured eardrum and fire. Health Canada has received several reports of ear injury from ear
candling.19 The sale of ear candles in Canada is illegal. Discourage the use of ear candles.
Relief of symptoms (ear fullness, hearing loss, ear discomfort) should occur as soon as the wax is expelled.
Initially, hearing loss or fullness may be exacerbated due to swelling of the wax within the canal. If irritation
of the canal occurs, use of the product should be discontinued. This is generally sufficient; however if the
irritation is severe or otitis externa develops, appropriate treatment may be required. The healthcare
practitioner should follow up with the patient after the third or fourth day of use to determine whether
symptom relief has occurred. Relief may occur more gradually (5–7 days) with oil-based products without
syringing; follow up after 5–7 days. If relief does not occur, further assessment and treatment may be
required.
Algorithms
1
Figure 1: Assessment of Patients with Impacted Earwax Symptoms
a See Figure 1 in Assessment of Patients with Hearing Loss, Ear Pain and Ear Drainage.
Drug Table
Table 2: Agents to Remove Excessive or Impacted Earwax
Drug/Costa Dosageb Comments
Drug Class: Softening Agents, oil-based
olive oil, 4–6 drops in Intended to soften earwax prior to syringing, or wax may be
mineral oil the ear canal allowed to be expelled naturally. In vitro data suggest oils are
(light), BID for up to ineffective for disintegrating earwax.13
almond oil 4 days or Generally not irritating.
3 drops in the
$ affected ear Effects are delayed (unless used just prior to syringing).
QHS for Hearing loss and fullness may initially be exacerbated due to
3–4 nights swelling of wax.
These agents may be instilled periodically (daily or 2–3 times
weekly) for prevention of impaction.
Drug Class: Softening Agents, water-based

Class Drug Dosagea Comments Costb
Softening water, Fill ear In vitro data suggest water-based $

Agents, saline, canal for products are more effective than oil-
Water- sodium 15–30 min based products.13 May use a few
based bicarbonate prior to drops of sodium bicarbonate or
(10–15%), syringing hydrogen peroxide 2–3 times weekly
hydrogen to prevent impaction.
peroxide
3%
Softening chlorbutol Use 5–10 The commercially available chlorbutol $$

Agents, 5% drops for product contains oil of terbinth
Water- Cerumol 10–15 min (turpentine oil), paradichlorobenzene
based and peanut oil. Turpentine is a
rubefacient and counterirritant used
topically to provide analgesia. It can
cause skin irritation.
Paradichlorobenzene gives the
characteristic smell to moth balls and
is used to repel insects. Their
inclusion in a product used to remove
earwax is questionable. Arachis oil
may induce allergic reactions and
patients allergic to peanuts should not
use this product. Health Canada has
received a report of anaphylaxis in a
peanut-allergic child with use of the
commercial product.20
Softening docusate 1 mL in No commercial otic preparation $$

Agents, sodium 10 the available; use oral solution.
Water- mg/mL affected
based generics ear for
10–15 min
followed
by
syringing
Softening carbamide 5–10 $$

Agents, peroxide drops in
Non- 6.5% affected
water, Murine Ear ear; leave
non-oil- Drops, in ear
based Murine Ear several
Wax minutes;
Removal any wax
System remaining
can be
removed
by gently
flushing
the ear
with warm
water. Use
BID for up
to 4 days
a For instructions on proper instillation of eardrops, see Eardrops—What You Need to Know in Otitis Media and Otitis
Externa
b Cost of smallest available pack size.
Legend: $ < $4 $$ $4–8
Suggested Readings
Aung T, Mulley GP. Removal of ear wax BMJ 2002;325:27.
McCarter DF, Courtney AU, Pollart SM. Cerumen impaction. Am Fam Physician 2007;75:1523-8.
Roland PS, Smith TL, Schwartz SR et al. Clinical practice guideline: cerumen impaction. Otolaryngol Head
Neck Surg 2008;139:S1-S21.
References
1. Roland PS, Smith TL, Schwartz SR et al. Clinical practice guideline: cerumen impaction. Otolaryngol
Head Neck Surg 2008;139:S1-S21.
2. Arnett A. Pain-earache. In: Fleisher GR, Ludwig S, Henretig FM, eds. Textbook of pediatric emergency
medicine. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 505-10.
3. McCarter DF, Courtney AU, Pollart SM. Cerumen impaction. Am Fam Physician 2007;75:1523-8.
4. Hawke M. Update on cerumen and ceruminolytics. Ear Nose Throat J 2002;81:23-4.
5. Browning GG. Ear wax. Clin Evid (Online) 2008;pii:0504.
6. Raman R. Impacted ear wax–a cause for unexplained cough? Arch Otolaryngol Head Neck Surg
1986;112:679.
7. Coppin R, Wicke D, Little P. Randomized trial of bulb syringes for earwax: impact on health service
utilization. Ann Fam Med 2011;9:110-4.
8. Rogers N, Stevermer JJ. PURLs: Ear wax removal: help patients help themselves. J Fam Pract
2011;60:671-3.
9. Aung T, Mulley GP. Removal of ear wax BMJ 2002;325:27.
10. Sharp JF, Wilson JA, Ross L et al. Ear wax removal: a survey of current practice. BMJ 1990;301:1251-
3.
11. Bird S. The potential pitfalls of ear syringing. Minimising the risks. Aust Fam Physician 2003;32:150-
1.
12. Hand C, Harvey I. The effectiveness of topical preparations for the treatment of earwax: a
systematic review. Br J Gen Pract 2004;54:862-7.
13. Saxby C, Williams R, Hickey S. Finding the most effective cerumenolytic. J Laryngol Otol
2013;127:1067-70.
14. Burton MJ, Doree C. Ear drops for the removal of ear wax. Cochrane Database Syst Rev 2009;
(1):CD004326.
15. Whatley VN, Dodds CL, Paul RI. Randomized clinical trial of docusate, triethanolamine polypeptide,
and irrigation in cerumen removal in children. Arch Pediatr Adolesc Med 2003;157:1177-80.
16. Roland PS, Eaton DA, Gross RD et al. Randomized, placebo-controlled evaluation of Cerumenex and
Murine earwax removal products. Arch Otolaryngol Head Neck Surg 2004;130:1175-7.
17. Eekhof JA, de Bock GH, Le Cessie S et al. A quasi-randomised controlled trial of water as a quick
softening agent of persistent earwax in general practice. Br J Gen Pract 2001;51:635-7.
18. Seely DR, Quigley SM, Langman AW. Ear candles–efficacy and safety. Laryngoscope 1996;106:1226-
9.
19. Government of Canada. Ear candling. Available from: healthycanadians.gc.ca/drugs-products-
medicaments-produits/buying-using-achat-utilisation/medical-procedures-medicales/ear-oreille-
eng.php. Accessed February 13, 2013.
20. Health Canada. Case presentation: Cerumol and anaphylaxis. Canadian Adverse Reaction Newsletter
2013;23:5. Available from: www.hc-sc.gc.ca/dhp-mps/alt_formats/pdf/medeff/bulletin/carn-
bcei_v23n1-eng.pdf. Accessed February 26, 2013.
Impacted Earwax
Impacted Earwax—What You Need to Know
General information about caring for your ears:
Ears generally clean themselves. It is not usually necessary to remove wax.

If you put any object into the ear canal (in particular cotton-tipped swabs), you may push wax farther in. This
can cause a wax buildup that blocks the ear (impaction). It may result in discomfort and hearing loss.
If earwax becomes impacted, you may need to use something to soften the wax so it will come out. You can
use:
4–6 drops of olive oil, almond oil or light mineral oil; or
a commercial eardrop. Follow the directions on the package.
For some products, such as olive oil, almond oil, light mineral oil or carbamide peroxide, you may have to put
drops in your ear twice a day for several days before the wax softens enough to come out on its own.
Some products (such as those containing chlorbutol) should remain in the ear for no more than 15 minutes
before you syringe them out.
Water or saline work as well as commercial products when used prior to syringing.
If you buy a commercial product, make sure you know how to use it safely before you leave the pharmacy. Ask
your pharmacist for advice.
Stop using any product that irritates your ears.
You may have heard or read about the use of ear candling to clean the ear canal. Ear candling is dangerous and
does not work. It can lead to injury of the ear and burns to the ears or face.
If you have repeated problems with earwax, you may be able to prevent the problem by using 4–6 drops of olive
oil, vegetable oil, light mineral oil, hydrogen peroxide or sodium bicarbonate 15% solution in your ears 2–3 times
a week.
See a health-care provider (and do not syringe the ears) if:
You have any of the following symptoms:

a rash in your ear
a history of ear surgery
tubes in your ears
an ear infection
received radiation treatment to the area
sharp foreign objects in the ear canal
You have any of the symptoms of a burst eardrum; this includes:
bleeding or discharge from the ear
dizziness
pain in the ear
ringing in the ears
hearing loss
How to syringe the ears:
Never attempt to flush out the ear canal if there is any possibility the eardrum has burst (see above) or ear tubes
are present. If you think you have a burst eardrum, see a health-care provider.
It is difficult to syringe your ears by yourself—get someone to help you.
Fill the ear syringe with warm water (body temperature).
Hold a basin just below the ear to catch the water coming out of the ear. Lay a towel over the shoulder.
For adults, straighten the ear canal by gently pulling the ear up and back. For a child, pull the ear down and back.
Insert the ear syringe just into the opening of the ear canal. Do not put it in farther—you could damage the ear.
Using the syringe, direct a stream of water along the upper surface of the ear canal so that the returning flow
pushes the earwax out from behind. Squeeze the syringe gently. Don’t force the water into the ear.
Otitis Media and Otitis Externa

Otitis Media
Pathophysiology
Acute otitis media (AOM) is an infection of the middle ear cavity and is one of the most common bacterial infections in
childhood.1 Seventy-five percent of children experience at least 1 episode prior to entering school.2 To diagnose AOM, 3 criteria
need to be met: 1) signs and symptoms of middle ear inflammation 2) the presence of middle ear effusion and 3) acute onset
(often abrupt) of signs and symptoms of middle ear inflammation and effusion.1 Symptoms include acute ear pain (often
unilateral and developing over a few hours), fever and reduced hearing.1 Tugging or pulling on the ears is often described, but this
is a very nonspecific sign.1 Children too young to complain of pain or pressure in the ears may display irritability, excessive
fussiness, poor feeding and disrupted sleep patterns. Acute otitis media is more common in the winter months. A recent history
of viral upper respiratory tract infection is often present.2 The microorganisms most commonly associated with AOM are
Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis.1,2
AOM has a high spontaneous recovery rate; 80% of children experience spontaneous symptomatic relief with placebo or no drug
therapy.3,4 For this reason, the concept of “watchful waiting” is advocated after appropriate healthcare practitioner assessment
and diagnosis of AOM. Rather than immediate initiation of antibiotic therapy, appropriately selected children are managed with
analgesic therapy for the first 24–48 hours. This includes children >6 months of age with no craniofacial abnormalities who have
uncomplicated AOM (normal host, no otorrhea, no history of chronic or recurrent AOM) without severe pain or systemic illness,
and whose caregivers are able to recognize severe illness, take the child for immediate assessment, and provide access to follow-
up care.1,2
Goals of Therapy
Relieve symptoms of fever, pain and irritability
Eliminate bacteria from the middle ear
Ensure appropriate therapy to reduce the risk of resistant pathogens and drug-related adverse effects such as antibiotic-
associated diarrhea
Prevent complications, e.g., mastoiditis, intracranial infection, facial paralysis
Comfort measures, such as warmed oils, warm or cold compresses and heating pads have been used by parents and caregivers
for years, although there are no studies evaluating their effectiveness. If tried, heat therapy should be used cautiously and with
close supervision in children, to avoid burns. A young child should never sleep with a hot water bottle or heating pad. Question the
caregiver about whether there has been any drainage from the ear prior to recommending any topical therapy. Warmed oil should
not be used if there is a chance of perforation or any suspicion of drainage. Warming of drops or oil should be done by rolling the
bottle between the palms; other methods such as placing the bottle in a glass of warm water or using the microwave oven should
be avoided as serious burns have been reported.
For more information on management of acute otitis media, consult the Compendium of Therapeutic Choices: Acute Otitis Media
in Childhood.
If antibiotics are used, systemic therapy is required; topical agents are not used in AOM.
Adequate analgesia with usual doses of acetaminophen or ibuprofen is important (see Fever, Table 5).
Topical analgesics may provide short-term analgesia in children with AOM, but should not replace oral analgesics.5,6 Topical
analgesics may cause local hypersensitivity reactions.
Decongestants and antihistamines, which were recommended in the past, do not speed the resolution of effusion and can
have significant adverse effects in children and therefore should not be used.7,8
For a more complete discussion of acute otitis media, see Suggested Readings.
.....
Otitis Externa
Otitis Externa
Pathophysiology
Otitis externa is defined as inflammation of the external auditory canal (EAC) and may also involve the pinna or tympanic
membrane (TM). Otitis externa is often due to infection.9,10,11,12 The EAC is warm, dark and prone to becoming moist. This
provides an excellent environment for bacteria or fungi to proliferate, particularly if the EAC is traumatized. Otitis externa can be
categorized as acute diffuse, acute localized, chronic, eczematous or necrotizing.12 The main focus of this chapter is acute
diffuse otitis externa.
Acute Diffuse Otitis Externa
Predisposing factors for acute diffuse otitis externa include:9,10,11,13
Too little cerumen—cerumen provides antibacterial action by physically protecting the canal and maintaining a low pH
Too much cerumen, which can lead to occlusion and maceration
Moisture (swimming, bathing, water sports, perspiration, increased humidity)—macerates underlying skin and raises pH
Trauma to EAC (caused by fingernails, cotton-tipped swabs, other foreign objects, overzealous wax removal)—abrasion
and laceration allowing inoculation of organisms
Chronic dermatologic disorders
Hearing aids
Narrow, hairy ear canal.
The most common etiology of acute otitis externa is bacterial infection. Fungal overgrowth occurs rarely, and primarily in
patients who have received prior antibiotic therapy. The 2 most common microorganisms causing acute otitis externa are
Pseudomonas aeruginosa (20–60%) and Staphylococcus aureus (10–70%).10,11
Bacterial otitis externa produces ear pain or discomfort (otalgia), otorrhea, pruritus and tenderness, especially on
manipulation of the ear.10,11 These symptoms may be more intense than those seen with fungal otitis externa. Cellulitis of the
pinna and regional lymphadenopathy may be present.10 Fungal otitis externa may be asymptomatic or may produce pruritus
and fullness in the ear. It classically occurs after prolonged treatment of bacterial otitis externa with antibiotics which alter the
bacterial flora of the EAC. The EAC may contain black, grey, bluish green, yellow or white fungal elements and debris.
Acute Localized Otitis Externa (Furunculosis)

This is an acute localized “boil” (infected hair follicle) in the ear canal usually due to S. aureus. It produces localized pain,
itching, edema, erythema and possibly a fluctuance or abscess. The pain subsides when the boil comes to a head and bursts.
Topical mupirocin or fusidic acid can be used for mild cases.14 Incision and drainage may be required for some patients.
Patients appearing to need incision and drainage should be seen by a healthcare practitioner with appropriate training. In
more severe cases, systemic antibiotics active against S. aureus should be considered.10
Chronic Otitis Externa

Chronic otitis externa is characterized as a thickening of the EAC skin secondary to low-grade infection and inflammation.
There is usually unrelenting pruritus, mild discomfort and dry, flaky skin in the EAC with lack of cerumen. This is often due to
nonbacterial causes including allergic contact dermatitis.9
Eczematous Otitis Externa

Eczematous otitis externa may be due to a variety of skin conditions, including atopic, seborrheic or contact dermatitis,
psoriasis, lupus erythematosus, neurodermatitis and infantile eczema. Lesions typically occur elsewhere on the body,
especially the head and neck, as well as the auricle and EAC. Appearance may range from mild erythema and scaling with
atopic dermatitis to the typical adherent scales of psoriasis (see Atopic, Contact, and Stasis Dermatitis; Dandruff and
Seborrheic Dermatitis; and Psoriasis for a more complete description of the lesions). The most common symptom is pruritus,
although erythema, edema, crusting and oozing may be present. The lesions may become secondarily infected with bacteria
or fungi. Treatment is primarily management of the underlying condition.15
Necrotizing (Malignant) Otitis Externa

This is an infection that extends to the mastoid or temporal bone and is usually seen in immunocompromised patients or
those with diabetes. Urgent referral and systemic antimicrobial therapy are required.10,11
This chapter focuses on the management of acute diffuse otitis externa.
Goals of Therapy
Eliminate pathogenic microorganisms
Control pain
Restore the canal to normal health so it resists infection—return to normal acidic pH and adequate cerumen
Patient Assessment
Acute otitis externa is characterized by otalgia (70% of cases), itching (60%) or fullness (22%) with or without hearing loss (32%)
and discharge in or coming from the ear (otorrhea).10,16 Incidence peaks in children age 7–12 years and declines after the age of
50.16 It is unilateral in 90% of cases.16 The discomfort can range from pruritus to severe pain. The pain is often worse with
motion of the ear (pushing the tragus or pulling the pinna),10 including movement caused by chewing.11 Determining the type of
otitis externa (infectious vs. noninfectious) can be assisted by the description of the signs and symptoms above and the
presence of contributing factors (e.g., history of swimming or trauma to the EAC), or the presence of dermatologic conditions on
areas of the body other than the EAC.
The drug must be delivered to the infected tissue if topical therapy is to be successful.10,16 Cleansing must be done by a
healthcare practitioner with appropriate training. Therefore, if there is significant edema or debris in the EAC, the patient may need
to be referred so that aural toilet can be performed or for a wick to be placed.10 In mild cases, a topical product may be initiated
without cleansing; recommendations for pain management are important.
Adequate cleansing of the ear canal with removal of debris may be required frequently so that topical therapy can be effective.9,10
If the canal is not patent, ear wicks may be inserted by a healthcare practitioner to reduce edema and swelling and provide a
mechanism for drug delivery to the canal.10,11 These may remain in place for 2–5 days.
Products: Internal Analgesics and Antipyretics; Otic Products.
Topical treatment is the mainstay of therapy for otitis externa, although systemic antibiotics may be required in more severe
cases, when infection has spread beyond the EAC, when otitis media coexists, or if the patient has a condition such as diabetes
or immunodeficiency.10 [Evidence: SORT A] In uncomplicated cases, systemic therapy does not improve outcomes compared
with topical therapy and increases time to clinical cure and the risks of both adverse effects and antibiotic resistance.17
[Evidence: SORT B] Topical therapy options include acidifying agents, antibiotics alone or antibiotic/corticosteroid combinations
(see Table 1). Comparative trials show similar outcomes among approaches; therefore, the choice is determined by healthcare
practitioner and patient preference, the side effect profile of the agents, and cost.10,11,12,18,19 One trial demonstrated that
corticosteroid drops (with either acetic acid or antibiotic) are more effective than acetic acid alone and recommended that acetic
acid alone not be used in adult patients.20 In patients whose symptoms last longer than a week, acetic acid may be less effective
than an antibiotic/corticosteroid combination; efficacy at 1 week is similar.18 Advantages and disadvantages of the various
products are outlined in Table 1.
Antibiotic drops are available as both otic and ophthalmic preparations. Both nonprescription and prescription products are
available. Otic products are more acidic than ophthalmic preparations and may cause burning on instillation. If a patient cannot
tolerate otic preparations, ophthalmic preparations may be more comfortable.21 Preparations for treatment of otitis externa may
contain corticosteroids, which reduce inflammation and edema and may resolve symptoms more quickly; however, this has not
been shown in all studies and corticosteroids may occasionally be topical sensitizers.18
One particular concern with topical therapy of acute otitis externa is the potential ototoxicity of aminoglycosides.22 This is a
documented adverse effect of systemically administered aminoglycosides. If the tympanic membrane is intact, the risk with
topical administration is extremely small. Risk factors for ototoxicity include ruptured tympanic membrane, use of the product for
more than 1 week and continued use after otorrhea has subsided. Topical fluoroquinolones have not been associated with
ototoxicity.
Enough liquid to fill the canal (3–4 drops) should be instilled 3–4 times daily (most products except fluoroquinolones). Symptoms
will last for approximately 6 days after treatment begins; however, improvement in symptoms should occur within 48–72 hours.10
Patients should be treated for 1 week. If symptoms are not completely gone, therapy can be continued until symptoms resolve
plus a few days beyond (up to 2 weeks).18 In 65–90% of patients, clinical resolution occurs in 7–10 days.10 For information on
correct instillation of eardrops, see Eardrops—What You Need to Know.
Fungal otitis externa often responds to cleansing and acidification alone, although topical antifungal agents (clioquinol,
clotrimazole, tolnaftate) may also be used.16 Some preparations may need to be compounded.
Otitis externa can be very painful. Usual doses of acetaminophen, ibuprofen or naproxen sodium can be used for analgesia (ASA
can be used in adults).10,11 Although some otic preparations contain topical anesthetics, the efficacy of these agents has not
been determined in acute otitis externa, and topical hypersensitivity reactions can occur.10 If topical anesthetic agents are used in
addition to other topical therapy, this will dilute the acidifier or antibiotic present in the canal. Avoid their use in otitis externa.
Systemic analgesia is the preferred recommendation.
Eczematous Otitis Externa
Eczematous otitis externa is managed by treating the underlying dermatologic disease (e.g., seborrhea, psoriasis, acne).9,15
Contact dermatitis commonly occurs on or in the ears, and grooming products (e.g., shampoos, hair sprays and hair dyes) are
common allergens.10 Hearing aids and earplugs may also cause dermatitis of the EAC. Neomycin is one of the topical
medications that most commonly causes allergic contact dermatitis.10 Patients sensitive to neomycin may also react to
tobramycin. Other agents commonly placed in the ear that are reported to cause contact dermatitis include benzalkonium
chloride, benzocaine and propylene glycol.23
Management includes avoiding the offending agent, applying acetic acid solution to dry oozing lesions and re-acidify the
canal, or symptomatic therapy with a topical corticosteroid.
Prevention of Recurrence
Provide information on how to prevent a recurrence to individuals who develop acute otitis externa:
After swimming or bathing, dry the external canal with a blow dryer on low setting or by instillation of acidifying or alcohol
drops.10,11,16
Avoid overzealous cleansing and scratching (trauma) of the ear canal.10
Avoid cotton-tipped swabs.11,16,24
Avoid water sports for at least 7–10 days during treatment.10
Ear plugs and bathing caps may be used to keep the ears dry; however, there is little evidence to guide recommendations.10
Frequent use of ear plugs may also act as a local irritant and promote infection.
Symptoms should be significantly reduced by day 3 of therapy,10,11 and for most patients symptoms should have completely
resolved in a week. Occasionally up to 14 days of treatment is needed.18 Follow up with the patient in 3–5 days to ensure
symptoms are improving and at the end of treatment to ensure resolution. If symptoms worsen or do not resolve, consider the
following: the patient may be reacting to the medication (contact dermatitis); a superinfection may have developed; the diagnosis
may be incorrect; improper or infrequent use of eardrops; inadequate penetration of topical agents due to debris or narrowing of
the canal; immunosuppression or malignant otitis externa; or the organism is not susceptible to the topical agent selected.9,10
Assessment for further treatment will be required.

Advise patients on:
Prevention of recurrences
Methods of pain control
Correct use of eardrops
Possible side effects of treatment and their management (see Table 1)
When to see a healthcare practitioner.
Drugs for Otitis Externa

Drugs for Otitis Externa
Table 1: Drugs for Otitis Externa
Class Drug Indications Adverse Comments Costa
Effects
Acidifying Agents acetic acid 2% Prevention Can be Broad-spectrum $

and irritating to antibacterial.25
treatment of inflamed canal.
mild AOE Restores acidity
Possibly to canal.
ototoxic.
Lower cost than
antibiotics.
No commercial
product
available. May
be prepared by
diluting white
vinegar with
equal parts
isopropyl alcohol
or water.10
Antibiotics ciprofloxacin Treatment of Well tolerated. Active against $

Ciloxan, generics AOE Not associated many gram-
with negative
ototoxicity. organisms
including P.
aeruginosa and
some gram-
positive (S.
aureus).
Twice-daily
dosing.
Topical
quinolones
provide similar
clinical cure
rates as other
topical
antibiotics.19
Ophthalmic
solutions can be
used in the ears.
Antibiotics gramicidin/polymyxin B Treatment of Potentially Gramicidin— $$

Optimyxin Ear Drops, Polysporin AOE ototoxic. active against
Eye/Ear Drops gram-positive
organisms.
Polymyxin B—
active against
gram-negative
organisms.
Effects
Antibiotics moxifloxacin Treatment of Well tolerated. Active against $$

Vigamox AOE Not associated many gram-
with negative
including P.
aeruginosa and
some gram-
positive (S.
aureus).
Twice-daily
dosing.
Topical
quinolones
provide similar
clinical cure
rates as other
topical
antibiotics.19
Ophthalmic
solutions can be
used in the ears.
Antibiotics ofloxacin Treatment of Well tolerated. Active against $

Ocuflox, generics AOE Not associated many gram-
with negative
including P.
aeruginosa and
some gram-
positive (S.
aureus).
Twice-daily
dosing.
Topical
quinolones
provide similar
clinical cure
rates as other
topical
antibiotics.19
Ophthalmic
solutions can be
used in the ears.
Antibiotics tobramycin Treatment of Potentially Aminoglycosides $

Tobrex, generics AOE ototoxic, active against
particularly gram-negative
with perforated organisms (e.g.,
tympanic Pseudomonas)
membrane, and S. aureus.
tympanostomy Ophthalmic
tubes or use >1 solutions can be
wk. used in the ears.
Effects
Corticosteroids dexamethasone Dermatologic May cause Anti- $

Maxidex causes of hypersensitivity inflammatory
AOE reactions. properties
reduce swelling
and edema.
If bacterial
etiology
combine with
acidifier or
antibiotic.
Ophthalmic
solutions can be
used in the ears.
Antibiotic/Corticosteroid ciprofloxacin/dexamethasone Treatment of Well tolerated. Active against $$$

Combinations Ciprodex AOE Not associated many gram-
with negative
May cause including P.
hypersensitivity aeruginosa and
reactions. some gram-
positive (S.
aureus).
Twice-daily
dosing.
Topical
quinolones
provide similar
clinical cure
rates as other
topical
antibiotics.19
Anti-
inflammatory
properties
reduce swelling
and edema.
Antibiotic/Corticosteroid clioquinol/flumethasone pivalate Treatment of Negligible Clioquinol active $$

Combinations Locacorten Vioform Eardrops AOE gram-negative against fungi
activity. and gram-
Bacteriostatic. positive bacteria.
May cause Anti-
hypersensitivity inflammatory
reactions. properties
reduce swelling
and edema.
Antibiotic/Corticosteroid framycetin/gramicidin/dexamethasone Treatment of Potentially Framycetin $$

Combinations Sofracort AOE ototoxic, active against
particularly gram-negative
with perforated organisms (but
tympanic not
membrane, Pseudomonas)
tympanostomy and S. aureus.
tubes or use >1 Gramicidin—
wk. active against
May cause gram-positive
hypersensitivity organisms.
reactions. Anti-
inflammatory
properties
reduce swelling
and edema.
Effects
Miscellaneous antipyrine/benzocaine Topical Benzocaine Do not use with $

Auralgan analgesia may produce ruptured
topical tympanic
hypersensitivity membrane.
reactions. Oral analgesics
Antipyrine— preferred.
mild
anesthetic; can
cause burning
and itching.
May mask
symptoms of
worsening
AOE.
Miscellaneous isopropyl alcohol 95%glycerin 5% Prevention of Painful when Useful drying $

Auro-Dri Ear Water AOE used in acute agent.
otitis externa.
a
Cost of smallest available pack size; includes drug cost only.
Abbreviations: AOE = acute otitis externa
Legend: $ < $10 $$ $10–20 $$$ $20–30
.....
Suggested Readings
Otitis Externa
Hui CP; Canadian Paediatric Society, Infectious Diseases and Immunization Committee. Acute otitis externa. Paediatr Child Health
2013;18:96-101.
Rosenfeld RM, Schwartz SR, Cannon CR et al. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg
2014;150:S1-S24.
Schaefer P, Baugh RF. Acute otitis externa: an update. Am Fam Physician 2012;86:1055-61.
Otitis Media
Le Saux N, Robinson J. Management of acute otitis media in children six months of age and older. Paediatr Child Health
2016;21(1):39–44.
Lieberthal AS, Carroll AE, Chonmaitree T et al. Diagnosis and management of acute otitis media. Pediatrics 2013:131:e964-99.
Vergison A, Dagan R, Arguedas A et al. Otitis media and its consequences: beyond the earache. Lancet Infect Dis 2010;10:195-
203.
References
1. Lieberthal AS, Carroll AE, Chonmaitree T et al. Diagnosis and management of acute otitis media. Pediatrics
2013;131:e964-99.
2. Le Saux N, Robinson J. Management of acute otitis media in children six months of age and older. Paediatr Child Health
2016;21(1):39–44.
3. Rosenfeld RM, Vertrees JE, Carr J et al. Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of
5400 children from thirty-three randomized trials. J Pediatr 1994;124:355-67.
4. Venekamp RP, Sanders SL, Glasziou PP et al. Antibiotics for acute otitis media in children. Cochrane Database of Syst Rev
2015;1:CD000219.
5. Carley SD. Best evidence topic reports. Towards evidence based emergency medicine: Best BETs from the Manchester
Royal Infirmary. Emerg Med J 2008;25:103.
6. Foxlee R, Johansson A, Wejfalk J et al. Topical analgesia for acute otitis media. Cochrane Database Syst Rev
2006;3:CD005657.
Otic Products: Otic Products

Auralgan Paladin liquid antipyrine 5.4%
benzocaine 1.4%
Auro-Dri Ear Water Drying Insight liquid isopropyl alcohol 95%

Aid
Cerumol Paladin liquid chlorbutol 5%

oil of terebinth 10%
paradichlorobenzene 2%
Murine Ear Drops Prestige liquid carbamide peroxide 6.5%
Murine Ear Wax Removal Prestige liquid carbamide peroxide 6.5%

System
Optimyxin Ear Drops Sandoz liquid gramicidin 0.025 mg/mL

polymyxin B sulfate 10 000
IU/mL
Polysporin Eye/Ear Drops Johnson & Johnson liquid gramicidin 0.025 mg/mL
IU/mL
Polysporin Plus Pain Johnson & Johnson liquid lidocaine hydrochloride 50

Relief Ear Drops mg/mL
IU/mL
Ear Conditions
Chapter 20: Otitis Media and Otitis Externa 215
Acute Otitis Externa (Swimmer's Ear)—What You Need to

Know
What is acute otitis externa?
Acute otitis externa, or “swimmer's ear,” is an infection of the ear canal. The symptoms are itching or
pain in the ear and liquid draining from it. The ear may become plugged. Your hearing may be
affected.
What causes acute otitis externa?

The skin in your ears may become infected because of:
■ Too much water in the ear (from bathing, swimming or water sports)
■ Removing the natural earwax that protects the ear canal
■ Skin conditions in the ear canal (such as eczema)
■ Using cotton-tipped swabs, fingernails or other sharp objects in the ear canal
■ Wax buildup due to hearing aids or other ear devices
What is the treatment for acute otitis externa?

■ The usual treatment is prescription eardrops. A healthcare provider may have to clean the ear canal
for the drops to work.
■ Most drops need to be used 3 or 4 times a day.
■ Use the drops until 3 days after all symptoms are gone.
■ Symptoms are usually much better in 3 days and should be gone in 10 days.
■ While you are using eardrops:
– Keep your ears as dry as possible. Take a bath instead of a shower. Avoid swimming and water
sports until the treatment is done.
– Don't poke your fingers or other objects into your ears.
What can you do to prevent acute otitis externa?

■ Keep the ear canal as dry as possible:
– Dry ears with a towel after swimming or bathing. Use a blow dryer set on low to dry the ear
canal. You can also use diluted vinegar or alcohol drops in the ear.
– Try using a bathing cap or ear plugs when swimming. If this makes it worse, stop using.
■ Do not clean earwax out of your ears:
– Earwax protects against infection. The ears generally clean themselves. If you have pain in your
ears from earwax, see your healthcare provider.
■ Do not put anything in the ear canal except eardrops. Fingernails, cotton-tipped swabs and other
objects irritate and damage the skin. If the skin is damaged you are more likely to get an infection.

Chapter 20: Otitis Media and Otitis Externa
216 Ear Conditions
Eardrops—What You Need to Know

Hints to help you use eardrops safely:
If possible, get someone to put the drops in your ear for you.
■ Warm the eardrops to body temperature by holding the bottle in your hands for a few minutes. Do
not heat the drops in hot water or the microwave because this could cause pain and dizziness or
serious burns.
■ Always wash your hands with soap and water before administering the eardrops.
■ The eardrops must be kept clean. Do not let the dropper touch the ear or anything else that could
have germs on it and let germs get into your eardrops.
■ Shake the bottle before using if there is a “Shake Well” label on the bottle. Lie on your side so that
the ear you are treating is facing up.
■ The ear canal must be straight so that the eardrops can reach the affected tissue. The direction that
you pull the top of the ear depends on the person's age.
– For adults and children over 3 years, gently pull the top of the ear up and back.
– For children under 3 years, gently pull the top of the ear down and back
■ Hold the dropper above the ear. Place the prescribed number of drops into the ear. Do not put the
dropper into the ear canal. It could injure the ear.
■ Stay in the same position for 3–5 minutes after using the drops. This will allow the eardrops to run
down into the ear canal.
■ A gentle to-and-fro movement of the ear will sometimes help in getting the drops to their intended
destination. You can also press with an in/out movement on the small piece of cartilage in front of
the ear.
■ Dry the earlobe if there are any eardrops on it.
■ If you have had a wick placed in your ear, do not remove it. It may fall out on its own as the
swelling and infection in the ear improves.
If you have to put drops in both ears:

Wait about 5–10 minutes before putting drops in the second ear. You want to be sure that the medicine
stays in the ear canal of the first ear long enough to reach the eardrum before you tilt your head to put
drops in the other ear.
These instructions may be changed by your healthcare provider depending on your medical condition
or the type of medicine in the eardrops.
© 2016 Consumer Health Information Corporation (www.consumer-health.com). All rights reserved. This information is adapted from Understanding
Canadian Prescription Drugs by Dorothy L. Smith, Pharm.D. published by Key Porter Books 1992.

Acute Cough
Daniel J.G. Thirion, BPharm, MSc, PharmD, FCSHP

Pathophysiology
Cough is a common symptom of many respiratory diseases and is a normal physiological response aimed
at protecting the respiratory tract. It is a voluntarily induced or involuntarily activated reflex arc that can be
triggered by a wide range of chemical and mechanical stimuli. First, receptors in the head, neck and chest
are stimulated. This information is then transmitted to the cough centre in the medulla via the afferent limb
of the vagus nerve, resulting in increased neural activity in the efferent pathway to both the respiratory
musculature and airway.1 Cough is present in many respiratory diseases. To help guide clinical assessment,
it can be useful to classify cough according to duration within the following 3 categories: acute (lasting <3
weeks), subacute (lasting 3–8 weeks) and chronic (lasting >8 weeks).2
Viral infections of the upper respiratory tract are the most common causes of acute cough and can lead to a
“post-infectious” cough.2 Cough due to viral infections appears to arise from stimulation of the cough reflex
in the upper respiratory tract caused by postnasal drip (referred to as upper airway cough syndrome—
formerly postnasal drip syndrome), clearing of the throat or both.3 Other frequent causes include acute
bacterial sinusitis, chronic bronchitis, allergic rhinitis, and rhinitis due to environmental irritants. See Table 1.
Bordetella pertussis or Bordetella parapertussis infection may be suspected in those with persistent cough.4
5
Table 1: Causes of Cough
Common Causes of Cough Less Common Causes of Cough
Asthma Bronchiectasis
Chronic bronchitis Cystic fibrosis
Drugs, e.g., ACE inhibitors, beta-blockers, ASA or Interstitial lung disease
NSAIDs in sensitive individuals Lung cancer
Environmental/occupational irritants, e.g., air pollution, Other lung diseases
cigarette smoke, asbestos
Psychogenic cough
Foreign body
Unexplained cough (idiopathic)
Gastroesophageal reflux disease
Zenker’s diverticulum (esophageal
Heart failure pouch)
Pulmonary embolism
Upper airway cough syndrome (sinusitis, allergic
rhinitis, postinfectious)
Upper/lower respiratory tract infection (viral or
bacterial)
Goals of Therapy
Alleviate symptoms
Diagnose and treat the underlying cause when possible
Prevent complications
Patient Assessment
An assessment algorithm for patients presenting with cough is presented in Figure 1.
Although evidence is lacking, hydration with oral liquids and humidification of room air may be beneficial.
Room humidifiers used as preventive measures should be well cleaned to avoid aerosolizing mould.
Mechanical methods such as postural drainage and chest percussion can improve airway clearance for
conditions such as increased production of secretions or dysfunctional clearance of secretions.6
Avoid exposure to inhaled irritants such as smoke, dust, pollutants and allergens.
Ailments—Cough, Cold and Allergy Products.
Treatment of underlying conditions contributing to cough is paramount. For example, in gastroesophageal

reflux disease, treatment of the reflux itself can alleviate associated cough. Smokers presenting with cough
are prime candidates for discussing smoking cessation strategies.7
A specific treatment is not always possible. For example, there is no cure for the viral infection that causes
the common cold. Despite a lack of evidence to support their use, nonspecific treatments such as
nonprescription antitussives and protussives (expectorants) are frequently used in these cases depending
on the presence/absence of mucus (sputum) production.
The efficacy of drugs used in the treatment of cough has been evaluated in numerous studies including
many systematic reviews.8,9,10 They show a lack of evidence for the effectiveness of nonprescription
products in terms of reducing the frequency or severity of cough in children or adults. Some studies have
shown benefit; however, the positive results in these studies were often of questionable clinical
relevance.11,12,13 Overall, there is little evidence for or against the effectiveness of nonprescription cough
medicines. When counselling patients on selecting products, also consider the placebo effect, which can be
significant.14
Nonprescription agents used in the management of cough are described in Table 3.
Antihistamines
First-generation antihistamines may have a small effect on cough caused by upper respiratory tract
infections.8,9,10,15 Their anticholinergic properties may reduce postnasal drip, which is one of the
mechanisms responsible for cough in the common cold. The effect is modest and side effects such as
drowsiness, dry mouth and confusion may outweigh potential benefit.
Second-generation antihistamines lack significant anticholinergic effects and therefore are not effective
for this indication.15
For dosage of antihistamines, see Allergic Rhinitis, Table 5.
Antitussives
The available nonprescription antitussives act centrally to suppress cough.15 The exact mechanism is
unknown; however, the brainstem is thought to be the main region where antitussive agents act to inhibit
motor control of cough.
Dextromethorphan and codeine are commonly used to treat cough related to upper respiratory tract
infections although there is little evidence for efficacy.8,9,10 Some studies have shown that they are no
more effective than placebo, while others demonstrated a modest benefit.15,16,17 The reason for this
discrepancy may be related to the limited efficacy of dextromethorphan in inhibiting cough, requiring
larger numbers of subjects to demonstrate a significant effect.15 Consequently, the American College of
Chest Physicians (ACCP) 2006 guideline on the management of cough does not recommend centrally
acting cough suppressants for cough secondary to upper respiratory tract infections.18 On the other
hand, codeine and dextromethorphan are effective for cough due to COPD, suppressing cough counts by
40–60%, and may be used for short-term relief.15
Antitussives are not recommended when a cough performs a useful function. If used by a patient with a
productive cough, more mucus is retained.19
Expectorants
The protussive agents act peripherally. Guaifenesin is purported to enhance cough effectiveness by
promoting the clearance of airway secretions.15 The efficacy and safety of guaiacol and ammonium
chloride have not been established. Expectorants are reported to reduce sputum viscosity permitting
more effective removal of secretions from the respiratory tract.2 As with antitussives, there is a lack of
evidence to support the efficacy of expectorants. They do not thin sputum or increase sputum volume,
even at doses higher than recommended.19 Good hydration with oral liquids and inhalation of humidified
air is perhaps the best protussive or “expectorant” measure.
Other Agents
Limited evidence suggests honey may be an effective cough suppressant in children.20,21 A Cochrane
review concluded that honey administered before sleep may be moderately better than no treatment or
diphenhydramine, and no different from dextromethorphan, for reducing cough severity and improving
sleep quality.20 Honey has demulcent, antioxidant and antibacterial effects. It is proposed that the
demulcent effect may act to decrease cough. Because of the risk of botulism, give pasteurized honey
only, to immunocompetent children over the age of 1 year.
Zinc lozenges have been used to alleviate cough due to the common cold. Studies evaluating the
efficacy of zinc in common cold symptoms have yielded conflicting results, and 2 meta-analyses have
concluded there is insufficient evidence to recommend zinc preparations.15 Therefore, the ACCP
guidelines do not recommend zinc preparations for acute cough due to the common cold. In addition,
zinc can be associated with unpleasant taste, mouth irritation and nausea.
Anesthetics such as benzocaine, phenol or menthol may reduce the sensitivity of peripheral nociceptors.
They have been used as antitussives, but evidence for efficacy is poor.
Prescription Therapy
Bronchodilators such as salbutamol or formoterol are recommended only for cough due to obstructive
lung disease such as asthma or COPD.18,22,23 Following a respiratory infection, patients sometimes
develop a cough for which corticosteroids could be beneficial. The potential benefit of inhaled
corticosteroids requires confirmation through further studies before making recommendations for their
routine use.
Cough in Special Populations
Children
For comparative ingredients of nonprescription products, consult the Compendium of Products for
Minor Ailments—Baby Care Products: Cough and Cold.
In 2008, Health Canada required manufacturers to relabel nonprescription cough and cold medicines
with certain active ingredients to indicate that they should not be used in children under 6 years.24
Dextromethorphan, guaifenesin and first-generation antihistamines contained in cough and cold
products are included in the list of active ingredients in the Health Canada advisory. See Viral Rhinitis,
Influenza, Sinusitis and Pharyngitis, Table 3.
Although cough and cold medicines have been used by children for many years, little evidence
supports their effectiveness in this population.10,17,25 In addition, reports of misuse, overdose and
very rare serious side effects have raised concerns about the use of these medicines in children
under 6 years.26 Rare but serious potential side effects include seizures, increased heart rate,
decreased level of consciousness, abnormal heart rhythms and hallucinations.24,25
In children ≥6 years, dextromethorphan can be used to treat nonproductive cough, though evidence
of efficacy in children is absent. Codeine should not be used in children <12 years.27
Pregnancy and Breastfeeding
See Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions.
Table 2 contains information on monitoring therapy.
Table 2: Monitoring of Therapy for Cough

Actions if Endpoint
Symptoms Monitoring Endpoint of Therapy Not Met
Cough Patient: Daily Patient able to perform Optimize
Healthcare practitioner: daily activities. nonpharmacologic
Next visit or by Patient able to sleep. measures.
telephone 2–3 days later Change treatment.
Drowsiness Patient: Daily No drowsiness. Change medication

(antitussive) Healthcare practitioner: schedule (bedtime only)
Next visit or by or change treatment.
telephone when
checking for efficacy

Advise patients regarding:
Proper use of medication
Expected results and management of side effects
When to contact a physician
Algorithms
Figure 1: Assessment of Patients with Cough
Guaifenesin is an
expectorant. It works
by thinning and
loosening mucus in
the airways, clearing
congestion, and
making breathing
easier.
a See Allergic Rhinitis.

b Cough and cold medicines are not recommended in children under 6 years of age (see Cough in Special
Populations, Children).
Abbreviations: ACE = angiotensin converting enzyme; ARB = angiotensin receptor blocker; COPD = chronic
obstructive pulmonary disease; DVT = deep vein thrombosis; GERD = gastroesophageal reflux disease; PE
= pulmonary embolus; SOB = shortness of breath
Drug Table
Table 3: Nonprescription Medications for Cough
Combination products:
Drug/Costa Dosageb Adverse Drug Interactions Comments

Effects
Drug Class: Antitussives
codeine Adults: 10–20 Drowsiness, CNS depressants, Causes less

CoActifed, mg Q4–6H po sedation, including alcohol, sedation than
Dimetane Maximum: nausea, enhance CNS side hydrocodone.
Expectorant-C, 120 mg/day vomiting, effects. Metabolized to
Dimetapp-C, constipation. MAOIs: Risk of morphine.
Children ≥12 serotonin Children are
Robitussin AC,
y: Give adult syndrome. more sensitive to
generics
dose adverse effects
CYP2D6 inhibitors,
$$ Health e.g., fluoxetine, of codeine.
Canada paroxetine, may Potential for
recommends inhibit conversion addiction.
against use of of codeine to its Nonprescription
codeine in active metabolite codeine products
children <12 y and reduce clinical always contain
For effect. other
combination ingredients.
products,
consult label
for additional
ingredients.
Follow
directions on
label.
Drug/Costa Dosageb Adverse Drug Interactions Comments
Effects
dextromethorphan Adults and Generally well Modulators of Causes less

Children ≥12 tolerated. serotonin: Risk of sedation than
Balminil DM, y: Occasional serotonin codeine and
Benylin DM; 10–20 mg dizziness, syndrome, e.g., other opioids.
Combination Q4H po drowsiness linezolid, MAOIs DM has been
products: or and nausea. (including abused for its
Robitussin DM, 30 mg Q6–8H moclobemide), euphoric effects.
others po sibutramine, SSRIs.
Maximum: CYP2D6 inhibitors,
$$ 120 mg/day e.g., fluoxetine,
Children: paroxetine, may
6–11 y: inhibit DM
5–10 mg Q4H metabolism
po resulting in
or increased DM
15 mg Q6–8H levels and potential
po for adverse effects.
Maximum:
60 mg/day
For
combination
products,
consult label
for additional
ingredients.
Follow
directions on
label.
Drug Class: Expectorants
guaifenesin Adults and Side effects No known

Robitussin Mucus Children ≥12 are rare. interactions.
& Phlegm, y: Dizziness,
generics 200–400 mg drowsiness,
Q4H po headache,
$$ Maximum: nausea and
2.4 g/day vomiting have
Children ≥6 y: been reported
12 mg/kg/day at high doses.
in divided
doses Q4H po
Maximum:
1.2 g/day
For
combination
products,
consult label
for additional
ingredients.
Follow
directions on
label.
a Cost of 100 mL, unless otherwise specified; includes drug cost only
b Cough and cold medicines are not recommended for use in children <6 years (see Cough in Special Populations,
Children).
Legend: $ < $2 $$ $2–5
Suggested Readings
Bolser DC. Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical
practice guidelines. Chest 2006;129:238S-49S.
Morice AH, McGarvey L, Pavord I et al. Recommendations for the management of cough in adults. Thorax
2006;61:i1-24.
Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults
in ambulatory settings. Cochrane Database Syst Rev 2014;11:CD001831.
References
1. Canning BJ, Chang AB, Bolser DC et al. Anatomy and neurophysiology of cough: CHEST Guideline
and Expert Panel report. Chest 2014;146:1633-48.
2. Dicpinigaitis PV. Cough: an unmet clinical need. Br J Pharmacol 2011;163:116-24.
3. Pratter MR. Cough and the common cold: ACCP evidence-based clinical practice guidelines. Chest
2006;129:72S-4S.
4. Braman SS. Postinfectious cough: ACCP evidence-based clinical practice guidelines. Chest
2006;129:138S-46S.
5. Pratter MR, Brightling CE, Loulet LP et al. An empiric integrative approach to the management of
cough: ACCP evidence-based clinical practice guidelines. Chest 2006;129:222S-31S.
6. Strickland SL. Year in review 2014: airway clearance. Respir Care 2015;60:603-5.
7. Morice AH, McGarvey L, Pavord I et al. Recommendations for the management of cough in adults.
Thorax 2006;61:i1-24.
8. Irwin RS, Madison JM. The diagnosis and treatment of cough. N Engl J Med 2000;343:1715-21.
9. Schroeder K, Fahey T. Systematic review of randomised controlled trials of over the counter cough
medicines for acute cough in adults. BMJ 2002;324:329-31.
10. Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and
adults in ambulatory settings. Cochrane Database Syst Rev 2014;11:CD001831.
11. Parvez L, Vaidya M, Sakhardande A et al. Evaluation of antitussive agents in man. Pulm Pharmacol
1996;9:299-308.
12. Curley FJ, Irwin RS, Pratter MR et al. Cough and the common cold. Am Rev Respir Dis 1988;138:305-
11.
13. Thackray P. A double-blind, crossover controlled evaluation of a syrup for the night-time relief of the
symptoms of the common cold, containing paracetamol, dextromethorphan hydrobromide,
doxylamine succinate and ephedrine sulphate. J Int Med Res 1978;6:161-5.
14. Paul IM, Beiler JS, Vallati JR et al. Placebo effect in the treatment of acute cough in infants and
toddlers: a randomized clinical trial. JAMA Pediatr 2014;168:1107-13.
15. Bolser DC. Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical
practice guidelines. Chest 2006;129:238S-49S.
16. Freestone C, Eccles R. Assessment of the antitussive efficacy of codeine in cough associated with
common cold. J Pharm Pharmacol 1997;49:1045-9.
17. Taylor JA, Norvack AH, Almquist JR et al. Efficacy of cough suppressants in children. J Pediatr
1993;122:799-802.
18. Irwin RS, Baumann MH, Bolser DC et al. Diagnosis and management of cough executive summary:
ACCP evidence-based clinical practice guidelines. Chest 2006;129:1S-23S.
Baby Care Products: Cough and Cold

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Hydrasense Ultra Gentle Mist Schering-Plough nasal spray natural source sea
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Nasadrops NeilMed Pharmaceutical nasal drops sodium chloride 0.9%
Otrivin Saline Sea Water for Novartis Consumer nasal spray sodium chloride 0.7%
Babies Health
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Rhinaris Lubricating Nasal Pendopharm nasal gel polyethylene glycol

Gel 15%
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Rhinaris Saline Nasal Spray Pendopharm nasal spray sodium chloride 0.9%
Rhinaris Saline Pediatric Pendopharm nasal drops sodium chloride 0.9%

Drops
Salinex Nasal Drops Sandoz nasal drops sodium chloride 0.9%
Salinex Nasal Lubricant Gel Sandoz nasal gel polyethylene glycol

15%
propylene glycol 20%
sodium chloride 0.9%
Salinex Nasal Lubricant Sandoz nasal spray polyethylene glycol 5%

Solution propylene glycol 16%
sodium chloride 0.9%
Allergic Rhinitis
Jennifer Kendrick, BScPharm, ACPR, PharmD

Pathophysiology
Allergic rhinitis affects 10–30% of the population, and the prevalence is increasing.1,2,3 It is estimated that
more than 500 million people worldwide are affected.3 The prevalence of allergic rhinitis is thought to be
highest in school-age children; 80% of people with allergic rhinitis are diagnosed before 20 years of age.1,4
Allergic rhinitis is associated with a genetic predisposition; children have a 30% chance of developing
allergic rhinitis if one parent is affected and a 50% chance if both are affected.5,6
Allergic rhinitis is characterized by inflammation of the nasal mucosa following inhalation of an

allergen.1,4,6,7 The allergic reaction is mediated by antigen-antibody responses and takes place in 3 phases.
The first phase, sensitization, occurs on first contact with the allergen. IgE is produced and binds to
receptors on the surface of mast cells and basophils. The second and third phases occur on re-exposure to
an allergen in a sensitized individual. The second phase, immediate reaction, occurs within minutes of re-
exposure and lasts up to 30–90 minutes. In this phase the allergen binds to allergen-specific IgE and the
mast cells release preformed mediators, histamine and tumor necrosis factor alpha (TNF-α), and newly
generated mediators, leukotrienes LTC4, LTD4, LTE4, prostaglandin D2 and kinins. The third phase, late
reaction, occurs 4–8 hours after exposure. It is characterized by migration of inflammatory cells,
eosinophils, monocytes, macrophages and basophils.
Allergic rhinitis was previously classified as seasonal or perennial; however, this classification was
determined to be inadequate for a number of reasons. For example, outdoor pollens and moulds may be
perennial in some regions and symptoms of perennial allergy may not be present year-round. The Allergic
Rhinitis and its Impact on Asthma (ARIA) guideline proposed the classifications of intermittent allergic
rhinitis (IAR) and persistent allergic rhinitis (PAR) in 2008.3 IAR is defined as symptoms of allergic rhinitis
occurring <4 days/week or for <4 weeks at a time. PAR is defined as symptoms of allergic rhinitis occurring
≥4 days/week and for ≥4 weeks at a time. Allergic rhinitis is further classified based on severity. In mild
allergic rhinitis, symptoms are present but not troublesome and there is no impairment in daily activities,
school or work and no sleep disturbance. In moderate/severe allergic rhinitis, one or more is present:
troublesome symptoms, impairment in daily activities, school or work, or sleep disturbance.3,7 The ARIA
classification has been validated in both adults and children.
Rhinitis may also be nonallergic. Conditions associated with nonallergic rhinitis are listed in Table 1. Drugs
associated with rhinitis are listed in Table 2.
3,4,6,7
Table 1: Possible Nonallergic Causes of Acute and Chronic Rhinitis
Drug-induced (see Table 2)
Hormones
pregnancy, menstruation, hypothyroidism
Infection
viral, bacterial, fungal, other
Nonallergic rhinitis with eosinophilia syndrome (NARES)
Other
emotions, e.g., stress, sexual arousal
vasomotor rhinitis, e.g., exercise, cold air
anatomic abnormalities, e.g., nasal septal deviation, enlarged adenoids and tonsils, nasal
tumors, choanal atresiaa
food and alcohol
nasal polyps
atrophy
foreign body
a A congenital defect where the posterior nares do not communicate with the nasopharynx.
6,8
Table 2: Drugs Associated with Rhinitis
ACE inhibitors Oral contraceptives
ASA and other NSAIDs Phosphodiesterase-5 inhibitors, e.g.,
Cocaine sildenafil
Diuretics, e.g., amiloride, Psychotropics, e.g., chlorpromazine,
hydrochlorothiazide risperidone
Gabapentin Sympatholytics, e.g., clonidine, doxazosin,
methyldopa, phentolamine, prazosin
Hydralazine
Topical decongestants (prolonged use)
Goals of Therapy
Prevent symptoms by avoiding exposure to allergen(s)
Alleviate signs and symptoms produced by the allergic response
Improve quality of life
Patient Assessment
The sensitization phase of allergic rhinitis is asymptomatic. Symptoms of the second or immediate phase
include sneezing, nasal and palatal pruritus, congestion and clear rhinorrhea.9 Symptoms of the delayed
phase are similar but nasal congestion predominates.4 Patients may also have itchy, red, watery eyes
(allergic conjunctivitis), itchy throat, ear fullness and popping, and a feeling of pressure over the cheeks and
forehead.4 Facial signs of allergic rhinitis are illustrated in Figure 1. The allergic salute is a sign more
commonly seen in children, where the patient wipes the nose with the palm of the hand in an upward
motion.
Figure 1: Facial Signs of Allergic Rhinitis
Morgan's Lines or Dennie's sign or folds are extra creases at the lower eyelids due to edema. Allergic shiners describe discoloured
infraorbital areas due to venous stasis resulting from nasal swelling. The transverse nasal crease is a crease seen at the junction of
the bulbous portion of the nose and the nosebridge and is caused by recurrent nose rubbing (allergic salute). Conjunctival injection
refers to conjunctival redness fading toward the edges.
Some patients present primarily with symptoms of sneezing and rhinorrhea, whereas others are mostly
bothered by nasal blockage and have little or no itching or sneezing.6 Eye symptoms are more commonly
associated with outdoor allergens.3,7
Allergic rhinitis can have a significant impact on a patient's quality of life. Patients may have headache,
difficulty concentrating, fatigue or sleep disturbance.6 Malaise or fatigue may be presenting complaints in
children.9 Complications of allergic rhinitis include sinusitis, otitis media, asthma, and sleep apnea. In
children, there may be dental overbite and a high-arched palate due to chronic mouth breathing.3,6
An assessment plan for patients suffering from allergic rhinitis is illustrated in Figure 2. During the
assessment, also identify precipitating factors/allergens and assess occupational exposure and response to
previous therapy.
Consider the need for prescription therapy or referral for allergy testing if the patient has already tried
appropriate nonprescription therapy for 2 weeks without an adequate response, or if the allergen responsible
for symptoms cannot be readily identified.3 Also refer patients for further assessment if they have signs or
symptoms that are unilateral or are not usually associated with allergic rhinitis (e.g., fever, pain, loss of smell
or taste, recurrent epistaxis, purulent nasal or ocular secretions, postnasal drip with or without rhinorrhea) or
symptoms suggesting complications such as asthma.3
Prevention
Prevention is the first step in the management of allergic rhinitis. Although consensus is that improvement
in symptoms should occur with allergen avoidance, little evidence supports individual measures.3 While
some measures such as washing pets, impermeable covers for bedding, and air filtration have been shown
to reduce the allergen level, a corresponding reduction in allergic symptoms has not been shown.9 The
benefits of environmental control may take weeks or months to fully manifest. Avoidance measures for
common allergens are presented below.1,3,6,7
Pollen
Keep windows and doors closed when at home or in the car.

If using air conditioning, keep the unit on recirculate or the indoor cycle, if the choice is available.
Do not use window or attic fans.
Monitor weather reports on pollen counts, if available. Decrease outdoor exposure during periods of
high pollen counts. Pollen counts tend to be highest on sunny, windy days.
Do not dry clothing outdoors.
Shower or bathe and wash hair after outdoor activity to remove pollen from hair and skin and
prevent contamination of bedding.
Outdoor Moulds
Remain in a closed environment as much as possible.

If using air conditioning, keep the unit on the indoor cycle, if the choice is available; note, however,
that units can be heavily contaminated with mould.
Use of face masks for activities such as raking leaves or working with compost or dry soil may have
limited value because air seeps around the edges of the mask and the mask does not protect the
eyes.
Indoor Moulds
Use fungicide on sinks, shower stalls, nonrefrigerated vegetable storage areas and garbage pails. A
solution of equal parts household bleach and water effectively kills mould.
Avoid console humidifiers and cool mist vaporizers; if these must be used, keep them scrupulously
clean.
If the home is built over a crawl space, install a plastic vapor barrier over exposed soil and keep
foundation vents open.
If the basement is damp or tends to flood, avoid carpeting or furnishing the basement. Use a
dehumidifier at all times and empty the extracted water from the air frequently; remove any
standing water as soon as possible.
Remove houseplants, which are a common source of mould. Alternatively, keep soil surface dry and
clean of debris to reduce mould.
House Dust Mites
Avoid carpeting the bedroom and main living areas.

Plastic, leather or wood furniture is best.
Some acaricides (e.g., benzyl benzoate, tannic acid) appear to reduce the mite population if used
regularly. However, their clinical effect is not established and they are not routinely recommended.3
If possible, clean while the allergic individual is not at home.
Mite-sensitive persons should avoid vacuuming or making beds. Those who must do their own
cleaning should wear a facemask during cleaning and for 10–15 minutes afterward.
Use a vacuum cleaner with an efficient double filtration system.
Keep indoor humidity between 40% and 45%.
Minimize use of humidifiers as excess humidity promotes mite growth.
Encase all mattresses, box springs and pillows in the allergic individual's bedroom in zippered,
allergen-proof casings.
Consider replacing old mattresses.
Wash bedding in hot (>55°C) water at least every 2 weeks. Cooler water temperatures will not kill
dust mites, nor will detergents.
Avoid stuffed toys that cannot be washed. Alternatively, put stuffed toys or pillows in a hot dryer or
in plastic bags and freeze every 2 weeks to kill dust mites.
Do not store items under the bed.
Use window shades instead of venetian blinds.
Evidence suggests the best strategy is a combination of the above interventions.10
Animal Allergens
Permanent removal of pets from the home is the best way to control animal allergens. This should
be followed by thorough cleaning of the house, including washing carpets. “Trial” removal of pets is
not helpful; it can take 20 weeks or longer for cat allergen levels to drop to levels comparable to
homes without cats.
If the family is unable to remove the animal from the home then:
remove carpets and replace with hard flooring
keep the animal away from the allergic individual's bedroom and other living areas where the
allergic individual spends time
a high-efficiency particulate air (HEPA) filter or electrostatic air purifier may be helpful
washing cats weekly and dogs once or twice weekly may help but evidence to support this
approach is lacking
eliminate litter boxes if possible; otherwise place them in an area unconnected to the air
supply for the rest of the house.
Occupational Allergens
For individuals affected by occupational rhinitis, recommend minimizing or eliminating exposure.

Common causes of occupational rhinitis include animal or vegetable proteins (e.g., mouse, rat,
wheat, grains, latex), enzymes, pharmaceuticals (e.g., antibiotics) and chemicals (e.g., resins).
Intranasal saline spray and irrigation has been shown to reduce nasal symptoms and the need for
pharmacologic therapy in children and nonpregnant adults.11 The effect of intranasal saline irrigation in
pregnant women is less clear.12 Isotonic saline is preferred to hypertonic saline, as it improves mucociliary
clearance; however, the optimal dose, frequency and delivery have not been established.11
Tobacco smoke can aggravate symptoms and should be avoided by all patients with allergic rhinitis.3 Other
irritants that should be avoided include insect sprays, air pollution and fresh tar or paint.3
When avoidance of allergens is ineffective or impractical, consider pharmacologic options. If it is possible to
predict the onset of symptoms (e.g., intermittent exposure), prophylactic medication should be started
before exposure.
Ailments—Cough, Cold and Allergy Products.
Table 3 summarizes the pharmacologic activity of different therapies for the treatment of allergic rhinitis.
7,13
Table 3: Comparative Symptom Relief of Allergic Rhinitis Therapies
Medication Rhinorrhea Congestion Sneezing Nasal Eye
Itch Symptomsa
Oral antihistamines + +/- + + +/-
Intranasal mast cell +/- +/- +/- +/- -

stabilizers
Decongestants (oral - + - - -
and topical)
Intranasal ++ ++ ++ ++ +/-
corticosteroids
Leukotriene receptor + + +/- +/- +/-

antagonists
Intranasal ++ - - - -
anticholinergics
Intranasal ++ ++ ++ ++ +/-
antihistamines
a See Conjunctivitis.
Abbreviations: (+/-) = modest or variable effect
Medications for treatment of allergic rhinitis are described in Table 5 and Table 6.
Several guidelines for the treatment of allergic rhinitis are available and each provides similar treatment
recommendations.3,6,7,9 For mild symptoms, second-generation antihistamines are the drugs of choice,
although they produce only a modest improvement in nasal congestion. First-generation antihistamines
are no longer recommended first-line due to their adverse effect profile.6 For moderate to severe allergic
rhinitis, regularly administered intranasal corticosteroids are recommended as first-line therapy.14
Antihistamines
Introduced in the 1940s, antihistamines were the first medications used for the treatment of allergic
rhinitis. They act as competitive antagonists for the histamine-1 (H1) receptor found on the surface of
target cells in the nose, lung, conjunctiva and skin.15 They also act as a reverse agonist, meaning that
they change the three-dimensional configuration of the receptor, decreasing its affinity for histamine
and down-regulating histamine-driven symptoms.15 Antihistamines decrease nasal itching, sneezing,
rhinorrhea, conjunctival itching and lacrimation but generally do not relieve nasal congestion.
Desloratadine, fexofenadine and cetirizine have modest effects on nasal congestion.16
Antihistamines are first-line treatment in mild cases of allergic rhinitis.3,6,9
Antihistamines are divided into 2 major classes: first- and second-generation. All are similarly
effective; however, adverse effect profiles and pharmacology differ.15,17,18,19,20,21
First-generation antihistamines have a rapid onset but relatively short duration of action due to their
short half-life.22,23 They are poorly selective for the H1 receptor and also exert effects on cholinergic
receptors. The anticholinergic effect manifests as dry mouth and nasal passages, difficulty voiding
urine, constipation and tachycardia. They are also highly lipophilic and therefore cross the blood-brain
barrier and interact with central H1 receptors. This results in CNS effects such as sedation and
psychomotor and cognitive impairment. In children, paradoxical excitation may occur.24 Performance
impairment has been documented using various measures (e.g., reaction time, visual-motor
coordination, arithmetical exercises and memory, learning and driving tests) although more recent
data suggest that the magnitude of these effects has been overstated.25,26 CNS depression and
impairment can be independent of any subjective complaints by the patient.27 First-generation
antihistamines also impair learning and academic performance in children.27 Workers taking first-
generation antihistamines have lower work performance and are more likely to be involved in
workplace accidents. Daytime performance effects are noted even when the antihistamine is taken
only at bedtime.6,27
First-generation antihistamines can decrease rhinorrhea, but mucus secretion may be thickened and
can be more bothersome for some patients.15
The first-generation antihistamines should be used with caution in patients with narrow-angle
glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy or
bladder-neck obstruction, cardiovascular disease and chronic lung disease.
Second-generation antihistamines are more selective for H1 receptors and less lipophilic.
Consequently, they do not have significant anticholinergic adverse effects and do not cross the blood-
brain barrier.20 Use of cetirizine in standard doses is associated with more sedation compared with
placebo, but less than first-generation antihistamines.6 Administration of standard doses of
loratadine and desloratadine results in an incidence of sedation equivalent to placebo; however,
drowsiness has been reported at higher than recommended doses, or rarely in susceptible individuals
at recommended doses.6 Fexofenadine appears to be nonsedating, even at increased doses. Due to
their improved adverse effect profile, especially with regard to sedation and psychomotor
performance, second-generation antihistamines represent a better choice than first-generation
agents for the treatment of allergic rhinitis.6,14 Clinical trials comparing various second-generation
antihistamines demonstrate similar reduction of symptoms.2,19,21,28 They are less effective than
intranasal corticosteroids for most symptoms of allergic rhinitis.6 Two meta-analyses demonstrated
intranasal corticosteroids were more effective than antihistamines for relieving congestion and
sneezing; for ocular symptoms, no difference was found.29,30
The intranasal antihistamine levocabastine is effective for sneezing, nasal pruritus and rhinorrhea. It
has a rapid onset of action (<15 minutes), but must be used 2–4 times daily.22 The intranasal
antihistamine azelastine (available only in combination with fluticasone in Canada) is clinically
similar to oral second-generation antihistamines for the relief of nasal symptoms.30
Antihistamines are more effective when taken before allergen exposure. The best results are
obtained with chronic dosing compared with intermittent dosing; therefore, patients should take the
antihistamine for as long as they are in contact with the allergen.14 If one antihistamine is not
effective, switching to another antihistamine may be beneficial.31
Mast Cell Stabilizers
Sodium cromoglycate (also called cromolyn sodium) modestly reduces itching, sneezing and
rhinorrhea but is not effective for nasal congestion.3 Treatment should begin before exposure to the
allergen and continue for the entire allergen season.22 If treatment begins after allergen exposure,
relief may be delayed up to 4 weeks. Sodium cromoglycate is less effective than corticosteroids for
allergic rhinitis and has not been adequately compared with leukotriene receptor antagonists and
antihistamines.6,30
Decongestants
Decongestants are available in oral and topical formulations. Oral decongestants generally have a
weaker effect on nasal obstruction than the topical formulations.22 When given orally, decongestants
can cause systemic adverse effects (see Table 5). Most available agents do not cause blood
pressure elevations in normotensive persons unless the recommended dose is significantly
exceeded.32 Elevation of blood pressure may occur at standard doses in hypertensive patients.33
Systemic absorption from topical formulations is low, resulting in mainly local adverse effects (see
Table 6). Rhinitis medicamentosa (rebound vasodilation) can occur if topical decongestants are used
for more than 3–5 days.34 In one study, 49% of patients reported using an intranasal decongestant
daily for at least one year, even though 80% reported having received education about limiting the
duration of use. Intranasal decongestant overuse was less common in patients who were using
intranasal corticosteroid or oral antihistamine.35 Overuse can lead to nasal congestion when the
topical agent is stopped, and to permanent overgrowth of nasal tissue with chronic overuse. This
condition is more likely to occur with shorter-acting agents (phenylephrine) than with longer-acting
agents (oxymetazoline and xylometazoline). Many solutions to this problem have been proposed,
including slow tapering of the decongestant, adding or switching to intranasal corticosteroids, or
abrupt discontinuation of the topical decongestant. Abrupt cessation is effective but may be
uncomfortable for the patient as nasal congestion may persist for several days or weeks.34
Corticosteroids
Intranasal corticosteroids are more effective against the nasal symptoms of allergic rhinitis than oral
and intranasal antihistamines, nasal cromoglycate and leukotriene receptor antagonists.29,30
Intranasal corticosteroids are the drugs of choice for moderate to severe or persistent allergic rhinitis,
and for mild allergic rhinitis that does not respond to antihistamines.3,6,9 Some intranasal
corticosteroids (mometasone furoate and fluticasone furoate) have a modest benefit on allergic
conjunctivitis symptoms.6,10,36,37,38 A meta-analysis suggests that intranasal corticosteroids as a
class are effective for ocular symptoms of allergic rhinitis; however the magnitude of effect has not
been quantified.39 Onset of action of intranasal corticosteroids is within 6–8 hours of first dose,
although maximum effect may take a few weeks. Short courses of oral corticosteroids may be
required for severe cases of allergic rhinitis that is unresponsive to other treatment.6 Patients may
prefer intranasal corticosteroids in aerosol form compared with spray form; therefore, switching to
another intranasal corticosteroid formulation may be recommended if patient tolerability is affecting
therapy.40 Regular use of intranasal steroids is more effective than intermittent use.14
Leukotriene Receptor Antagonists (LTRA)
Montelukast is superior to placebo but less effective than intranasal corticosteroids for nasal
symptoms of allergic rhinitis.30 Montelukast is similar in efficacy to loratadine, but patient response
is more variable than with antihistamines.30 There may be additive effects when it is used
concomitantly with antihistamines. Montelukast is more effective than oral antihistamines and
comparable to intranasal corticosteroids for reduction of asthma symptoms and use of rescue
asthma medication.30 As a result, montelukast may be a reasonable option for allergic rhinitis
coexisting with asthma.6,7,9 Otherwise, montelukast is not recommended as first-line therapy for
allergic rhinitis.9
Immunotherapy
According to clinical practice guidelines, allergen immunotherapy should be considered for patients
who continue to have moderate to severe symptoms despite treatment or those who require systemic
corticosteroids.2,9 Immunotherapy may be indicated when the exposure to allergens is significant
and unavoidable (e.g., grass pollen), and when the symptom complex is severe enough to warrant the
time, expense and small risk of anaphylaxis.6 Allergen immunotherapy is the only treatment that can
modify the natural history of allergic rhinitis and potentially induce long-term disease remission after
cessation of treatment. It may also prevent the development of new allergies and reduce the risk of
development of asthma in children. Therefore, allergen immunotherapy may be considered even in
milder cases of allergic rhinitis. Immunotherapy is administered by subcutaneous injection, although
sublingual immunotherapy seems to be somewhat effective as well.6,41,42
Anticholinergics
Intranasal ipratropium bromide is effective for rhinorrhea secondary to allergic rhinitis but not for
other symptoms.22
Combination Therapies
Combination therapy is recommended by some guidelines when patients have inadequate response to
monotherapy.9 Some combinations have been shown to be more effective than monotherapy while
others have not.
First- and Second-generation Antihistamines
Some experts suggest a second-generation antihistamine during the day and a first-generation
antihistamine at bedtime to promote sleep. Evidence to support this practice is lacking and next-day
sedation is possible.2 If sleep is disturbed due to allergies, symptom relief itself can be expected to
improve sleep.
Antihistamine plus Decongestant
Because antihistamines may have only a modest effect on nasal congestion, antihistamines and
decongestants are often combined. Some patients may respond to this combination when
corticosteroids have failed or when either medication alone does not provide adequate relief of nasal
symptoms.2,30
Antihistamine plus Corticosteroid
Intranasal corticosteroids are often combined with oral antihistamines to treat severe or resistant
cases of allergic rhinitis.6 This strategy seems logical because the 2 drugs have different
mechanisms of action. Evidence is insufficient to support the combination of intranasal
corticosteroids and oral antihistamines, as it has not been consistently shown to be superior to either
medication alone.2,30 However, intranasal corticosteroid in combination with intranasal antihistamine
(fluticasone/azelastine) is more effective for the nasal symptoms of allergic rhinitis than either
medication alone.30
Antihistamine or Intranasal Corticosteroid plus LTRA
An additive effect has been shown when LTRAs and either oral antihistamines or intranasal
corticosteroids are used concomitantly.30 The efficacy of oral antihistamines in combination with a
LTRA is less than that of intranasal corticosteroids alone.6 However, antihistamine-LTRA combination
therapy may provide an alternative for patients who are unresponsive or nonadherent to intranasal
corticosteroid therapy.
Special Populations
Children
The guidelines for treatment of allergic rhinitis in children are similar to those for adults.6 Healthcare
practitioners must ensure they select the correct dosage, ensure proper administration and minimize
adverse effects.3,7,24 Most second-generation antihistamines are now available in pediatric
formulations for children >6 months and are generally preferred over first-generation agents due to
improved adverse effect profiles. Table 5 and Table 6 provide dosage guidelines and age limits for
oral and intranasal agents. Intranasal corticosteroids are also effective and are considered safe in
children >2 years of age, depending on the formulation.24 Intranasal budesonide and mometasone
furoate have not shown growth suppression with prolonged use at recommended doses.6,43,44
Intranasal beclomethasone dipropionate, fluticasone propionate and triamcinolone acetonide have
been shown to reduce growth velocity by 0.2–0.9 cm per year within the first year of
treatment.45,46,47 Longer term studies have not been conducted. If intranasal corticosteroids are
used, use the lowest possible dose, monitor growth and use other therapies (e.g., antihistamines) to
minimize the dose of corticosteroid required for symptom control.6 Decongestants are not
recommended for use in children under 6 years.48,49 In those children, intranasal saline drops or
spray may be used to clear nasal passages before eating or sleeping.
Pregnancy
Intranasal cromoglycate and intranasal corticosteroids are both considered safe during pregnancy
although beclomethasone, budesonide and fluticasone propionate have accumulated more safety
data than other intranasal corticosteroids.6 Neither first- nor second-generation antihistamines have
been associated with teratogenic effects in pregnancy.50,51 First-generation antihistamines were
previously favoured because of substantially greater experience; however, safety data for cetirizine
and loratadine now indicate these are acceptable options. Chlorpheniramine has a good safety
record in pregnancy. Although diphenhydramine has good safety data and is still recommended and
frequently used in pregnancy, there have been isolated reports of cleft palate.51 Sedation and
impaired performance may limit the use of first-generation antihistamines. Oral decongestants
should be avoided in the first trimester.51 A topical decongestant may be used; at usual doses, they
do not present a risk to the fetus. Immunotherapy generally should not be started during pregnancy.
Courses of immunotherapy started prior to conception may be continued if beneficial and not
causing systemic reactions; doses should not be increased during pregnancy.52 See Pregnancy and
Breastfeeding: Self-care Therapy for Common Conditions.
Breastfeeding
Recommendations for breastfeeding are similar to those during pregnancy. Both first- and second-
generation antihistamines are considered safe while breastfeeding.53 First-generation
antihistamines may in theory diminish milk production via their anticholinergic effect; however, this
has not been reported in practice. Infant somnolence should be monitored when a first-generation
antihistamine or cetirizine is used.
The systemic absorption of topical decongestants is low and transfer into breast milk is unknown.
Consequently, these agents are expected to be reasonably safe during breastfeeding.
The American Academy of Pediatrics considers pseudoephedrine to be compatible with

breastfeeding.51 Information on the use of other oral decongestants during breastfeeding is limited.
Information on the use of topical sodium cromoglycate during breastfeeding is not available,
although the manufacturer recommends caution.
Table 4 provides a monitoring plan framework that should be individualized.
Table 4: Monitoring of Therapy for Allergic Rhinitis

Symptoms Monitoring Endpoint of Actions
Therapy
Allergic symptoms Patients: Daily Patient able to If nonprescription therapy is
(sneezing, runny Healthcare perform daily ineffective after 1 wk,
nose, itchy and practitioner: Next activities. optimize allergen avoidance
watery eyes, visit or by telephone Patient able to and medication dose (if
congestion, 1 wk later sleep. applicable). If symptoms not
rhinorrhea) controlled after a further wk
of therapy, consider another
agent. Refer as necessary.3
Therapy
Drowsiness Patient: Daily Patient not drowsy Switch to a less sedating
(antihistamine) Healthcare during the day. antihistamine. If using
practitioner: Next cetirizine, could give dose at
visit or by telephone bedtime.
when checking for
efficacy
Insomnia Patient: Daily No insomnia. Change medication schedule

(oral decongestant) Healthcare so last dose taken 4–6 h
practitioner: 1 wk before bedtime or
discontinue medication.
Elevated blood Patient: Daily No elevation in Stop decongestant if blood

pressure in Healthcare blood pressure pressure elevated above
hypertensive practitioner: Monitor above baseline. baseline.
patients blood pressure of
(oral decongestant) hypertensive
patients twice in the
first wk

Advise all patients about allergen avoidance. In addition, patients who require drug therapy should receive
counselling regarding proper use of the medication, expected results and management of adverse effects
(see Table 4).
Algorithms
3,4,6,7
Figure 2: Assessment and Initial Treatment of Patients with Allergic Rhinitis
<2 years
Sinusitis
Otitis media
asthma
Drug Tables
Table 5: Oral Agents for Allergic Rhinitis

Interactions
Drug Class: Antihistamines, First-generation

Interactions
chlorpheniramine Adults: 4 mg Q4–6H CNS: Sedation, Increased CNS

Chlor-Tripolon, po; maximum fatigue, depression when
generics 24 mg/day dizziness, combined:
Children: impairment of Alcohol,
$ cognition and sedatives,
0.35 mg/kg/day
divided Q4–6H po performance. tranquilizers,
or Anticholinergic: barbiturates.
2–5 y: 1 mg Q4–6H Dry mouth and Increased
po; maximum eyes, anticholinergic
6 mg/day constipation, side effects
6–11 y: 2 mg Q4–6H urinary retention. when combined
po; maximum with: TCAs,
12 mg/day scopolamine.
Increase
chlorpheniramine
levels resulting in
increased
adverse effects
when combined
with moderate
CYP2D6
inhibitors, e.g.,
amiodarone,
celecoxib.
Avoid
combination with
strong CYP2D6
inhibitors, e.g.,
bupropion,
paroxetine.
diphenhydramine Adults: 25–50 mg CNS: Sedation, Increased CNS Available in

Benadryl Q6–8H po; maximum fatigue, depression: pediatric liquid
Preparations, 300 mg/day dizziness, Alcohol, formulation.
generics Children: impairment of sedatives,
5 mg/kg/day given in cognition and tranquilizers,
$ performance. barbiturates.
3 or 4 divided doses
po Anticholinergic: Increased
2–5 y: Maximum Dry mouth and anticholinergic
37.5 mg/day eyes, side effects
6–11 y: constipation, when combined
Maximum150 mg/day urinary retention. with: TCAs,
scopolamine.
May increase
levels of CYP2D6
substrates, e.g.,
metoprolol,
venlafaxine.
Drug Class: Antihistamines, Second-generation

Interactions
cetirizine Adults: 5–10 mg Minimal to no Increased CNS Active

Reactine, Q24H po; maximum anticholinergic depression: metabolite of
generics 20 mg Q24H po effects. Alcohol, hydroxyzine.
Children: May cause sedatives, Available in
$ 6–12 months: 2.5 mg drowsiness in tranquilizers, pediatric 5 mg
Q24H po some individuals barbiturates. rapid-dissolve
12–23 months: especially at Increased tablet.
2.5 mg Q24H po; higher doses. anticholinergic Available as 5
maximum 2.5 mg Headache. side effects: mg/5 mL syrup.
Q12H TCAs,
2–5 y: 2.5 mg Q24H scopolamine.
po; maximum
5 mg/day in 1 or 2
doses
≥6 y: Adult dosage
desloratadine Adults: 5 mg Q24H po Minimal to no P-gp inhibitors Active

Aerius, generics Children: anticholinergic (e.g., metabolite of
6–11 months: 1 mg effects. erythromycin, loratadine.
$ Q24H po Headache. ketoconazole) Available in
1–5 y: 1.25 mg Q24H may increase pediatric liquid
po loratadine levels formulation.
6–11 y: 2.5 mg Q24H while P-gp
po inducers (e.g.,
carbamazepine,
dexamethasone)
may decrease
loratadine levels;
clinical effect
probably
minimal.
fexofenadine Adults: 60 mg Q12H Minimal to no Decreased Active

Allegra po anticholinergic fexofenadine metabolite of
Sustained-release: effects. level: Aluminum- terfenadine.
$ 120 mg Q24H po Headache. and magnesium- Only 5% of a
Children: containing dose is
2–11 y: 30 mg Q12H antacids. metabolized.
po Ingestion of fruit
juices such as
apple, grapefruit
or orange may
decrease
bioavailability.
Interactions
loratadine Adults: 10 mg Q24H Minimal to no QTc prolongation Available in

Claritin, Claritin po anticholinergic reported with pediatric liquid
Liquid Capsules, Children: effects. concomitant use formulation and
generics 2–5 y: 5 mg Q24H po Headache. of loratadine and rapid-dissolve
≥5 y: 10 mg Q24H po amiodarone. tablets.
$ Caution is
advised.
P-gp inhibitors
(e.g.,
erythromycin,
ketoconazole)
may increase
loratadine levels
while P-gp
inducers (e.g.,
carbamazepine,
dexamethasone)
may decrease
loratadine levels;
clinical effect
probably
minimal.
Drug Class: Decongestants
pseudoephedrine Adults: 60 mg Q4–6H Mild CNS Beta-blockers: Caution in

po; maximum 240 stimulation Antihypertensive patients with
Eltor 120, mg/day (nervousness, effects may be heart disease,
Sudafed, Sustained-release: excitability, reduced. high blood
generics 120 mg Q12H po; restlessness, Contraindicated pressure,
maximum 240 dizziness, with MAOIs and hyperthyroidism,
$$ mg/day weakness, ergot derivatives. diabetes, angle
Children: insomnia). Avoid use with closure
6–11 y: 30 mg Q4–6H Peripheral phenothiazines glaucoma and
po vasoconstriction. and selective prostatic
Maximum Tachycardia or serotonin enlargement.
120 mg/day palpitation may reuptake Concurrent use
≥12 y: adult dose occur. Blood inhibitors. with or use
pressure may be within 2 weeks
increased in of MAOIs may
hypertensive cause
subjects. May hypertensive
adversely affect crisis.
blood sugar
control in
diabetics.
Drug Class: Antihistamine, Second-generation/Decongestant Combinations

Interactions
cetirizine / Adults: 1 tab (5 Minimal to no Increased CNS Active

pseudoephedrine mg/120 mg) Q12H po anticholinergic depression: metabolite of
Children: effects. Alcohol, hydroxyzine.
Reactine ≥12 y: Give adult dose May cause sedatives, Available in
Complete drowsiness in tranquilizers, pediatric 5 mg
some individuals barbiturates. rapid-dissolve
$$ especially at Increased tablet.
higher doses. anticholinergic Available as 5
Headache. side effects: mg/5 mL syrup.
Mild CNS TCAs,
stimulation scopolamine. Caution in
(nervousness, Beta-blockers: patients with
excitability, Antihypertensive heart disease,
restlessness, effects may be high blood
dizziness, reduced. pressure,
weakness, Contraindicated hyperthyroidism,
insomnia). with MAOIs and diabetes, angle
Peripheral ergot derivatives. closure
vasoconstriction. Avoid use with glaucoma and
Tachycardia or phenothiazines prostatic
palpitation may and selective enlargement.
occur. Blood serotonin Concurrent use
pressure may be reuptake with or use
increased in inhibitors. within 2 weeks
hypertensive of MAOIs may
subjects. May cause
adversely affect hypertensive
blood sugar crisis.
control in
diabetics.
Interactions
desloratadine / Adults: 1 tab (2.5 Minimal to no P-gp inhibitors Active

pseudoephedrine mg/120 mg) Q12H po anticholinergic (e.g., metabolite of
Children: effects. erythromycin, loratadine.
Aerius Dual ≥12 y: Give adult dose Headache. ketoconazole) Available in
Action 12 Hour Mild CNS may increase pediatric liquid
stimulation loratadine levels formulation.
$$ (nervousness, while P-gp Caution in
excitability, inducers (e.g., patients with
restlessness, carbamazepine, heart disease,
dizziness, dexamethasone) high blood
weakness, may decrease pressure,
insomnia). loratadine levels; hyperthyroidism,
Peripheral clinical effect diabetes, angle
vasoconstriction. probably closure
Tachycardia or minimal. glaucoma and
palpitation may Beta-blockers: prostatic
occur. Blood Antihypertensive enlargement.
pressure may be effects may be Concurrent use
increased in reduced. with or use
hypertensive Contraindicated within 2 weeks
subjects. May with MAOIs and of MAOIs may
adversely affect ergot derivatives. cause
blood sugar Avoid use with hypertensive
control in phenothiazines crisis.
diabetics. and selective
serotonin
reuptake
inhibitors.
fexofenadine / Adults: 1 tab Minimal to no Decreased Active

pseudoephedrine (60 mg/120 mg) anticholinergic fexofenadine metabolite of
Q12H po effects. level: Aluminum- terfenadine.
Allegra-D Children: Headache. and magnesium- Only 5% of a
≥12 y: Give adult dose Mild CNS containing dose is
$$ stimulation antacids. metabolized.
(nervousness, Ingestion of fruit Caution in
excitability, juices such as patients with
restlessness, apple, grapefruit heart disease,
dizziness, or orange may high blood
weakness, decrease pressure,
insomnia). bioavailability. hyperthyroidism,
Peripheral Beta-blockers: diabetes, angle
vasoconstriction. Antihypertensive closure
Tachycardia or effects may be glaucoma and
palpitation may reduced. prostatic
occur. Blood Contraindicated enlargement.
pressure may be with MAOIs and Concurrent use
increased in ergot derivatives. with or use
hypertensive Avoid use with within 2 weeks
subjects. May phenothiazines of MAOIs may
adversely affect and selective cause
blood sugar serotonin hypertensive
control in reuptake crisis.
diabetics. inhibitors.
Interactions
loratadine / Adults: 1 tab (5 Minimal to no QTc prolongation Available in

pseudoephedrine mg/120 mg) Q12H po anticholinergic reported with pediatric liquid
or effects. concomitant use formulation and
Claritin Allergy + 1 tab (10 mg/240 mg) Headache. of loratadine and rapid-dissolve
Sinus, Claritin Q24H po Mild CNS amiodarone. tablets.
Allergy + Sinus Children: stimulation Caution is Caution in
Extra Strength ≥12 y: Give adult dose (nervousness, advised. patients with
excitability, P-gp inhibitors heart disease,
$$ restlessness, (e.g., high blood
dizziness, erythromycin, pressure,
weakness, ketoconazole) hyperthyroidism,
insomnia). may increase diabetes, angle
Peripheral loratadine levels closure
vasoconstriction. while P-gp glaucoma and
Tachycardia or inducers (e.g., prostatic
palpitation may carbamazepine, enlargement.
occur. Blood dexamethasone) Concurrent use
pressure may be may decrease with or use
increased in loratadine levels; within 2 weeks
hypertensive clinical effect of MAOIs may
subjects. May probably cause
adversely affect minimal. hypertensive
blood sugar Beta-blockers: crisis.
control in Antihypertensive
diabetics. effects may be
reduced.
Contraindicated
with MAOIs and
ergot derivatives.
Avoid use with
phenothiazines
and selective
serotonin
reuptake
inhibitors.
Drug Class: Leukotriene Receptor Antagonists

Interactions
montelukast Adults and children Headache, Strong CYP2C9 Strong CYP2C9

Singulair, ≥15 y: 10 mg QHS abdominal pain, and 3A4 inducers and 3A4
Montelukast, Children: flu-like (e.g., inducers (e.g.,
other generics 6–14 y: 5 mg QHS symptoms. carbamazepine, carbamazepine,
2–5 y: 4 mg QHS phenobarbital, phenobarbital,
$$ phenytoin, phenytoin,
rifampin) may rifampin) may
decrease decrease
montelukast montelukast
levels whereas, levels whereas,
strong CYP2C9 strong CYP2C9
inhibitors (e.g., inhibitors (e.g.,
sulfadiazine) fluconazole)
may increase may increase
montelukast montelukast
levels; clinical levels; clinical
significance is significance is
uncertain; uncertain;
however, monitor however,
for reduced monitor for
efficacy or reduced efficacy
adverse effects. or adverse
effects
a Cost of 10-day supply; includes drug cost only
Abbreviations: CNS = central nervous system; MAOI = monoamine oxidase inhibitor; SR = sustained-release
Legend: $ < $10 $$ $10–20

Table 6: Intranasal Agents for Allergic Rhinitis
Drug/Costa Dosage Adverse Comments

Effects
Drug Class: Antihistamines
levocabastine Adults and Children Nasal Shake well before use.

Livostin Nasal Spray (≥12–65 y): 2 sprays (50 irritation. Initial priming
µg/spray) per nostril BID; required.
$$$ may increase to 2 sprays
TID–QID Discontinue if no
improvement seen
within 3 days.
Drug Class: Antihistamine/Corticosteroid Combinations

Effects
azelastine/fluticasone Adults and children ≥12 y: 1 Burning or Avoid use with

Dymista spray (137 µg/50 µg) in stinging, ritonavir due to
each nostril BID nosebleeds. potential for systemic
$100 corticosteroid effects.
Dysgeusia
may occur if Rarely causes
patient tilts drowsiness.
head back too
far during
administration.
Drug Class: Corticosteroids
beclomethasone Adults and children ≥6 y: 2 Burning or Use at regular

generics sprays (50 µg/spray) in each stinging, intervals. Slow onset
nostril BID nosebleed. (7–14 days for
$$ Adults: Maximum 12 May cause maximal effect).
sprays/day mild growth Drug may fail to reach
Children: Maximum 8 suppression the site of action if
sprays/day with prolonged excessive nasal
Use lowest effective dose use.45,46,47 mucus secretion or
for maintenance therapy edema of the nasal
mucosa is present.
May use a
vasoconstrictor
(intranasal
decongestant) 2–3
days prior to the
suspension.
Aim spray up towards
turbinates and away
from septum. Liquid
forms may be more
effective than
metered-dose
inhalers.
Effects
budesonide Nasal suspension: Burning or Use at regular

Rhinocort Aqua, Adults and children ≥6 y (64 stinging, intervals. Slow onset
Rhinocort Turbuhaler µg/metered dose): Initial nosebleed. (7–14 days for
dose 2 sprays in each nostril May cause maximal effect).
$$-$$$ daily mild growth Drug may fail to reach
or suppression the site of action if
1 spray in each nostril BID; with prolonged excessive nasal
may decrease maintenance use.45,46,47 mucus secretion or
dose to 1 spray in each edema of the nasal
nostril daily mucosa is present.
Nasal powder: May use a
Adults and children ≥6 y ( vasoconstrictor
100 µg/dose): (intranasal
Initial dose 2 applications in decongestant) 2–3
each nostril in the morning days prior to the
or suspension.
1 application in each nostril Aim spray up towards
BID; may decrease turbinates and away
maintenance dose to 1 from septum. Liquid
spray in each nostril daily forms may be more
Maximum 400 µg/day effective than
metered-dose
inhalers.
For the nasal
suspension, initial
priming needed. Re-
prime if not used ≥4
days.
ciclesonide Adults and children ≥12 y: 2 Burning or Use at regular

Omnaris sprays (50 µg/spray) in each stinging, intervals. Slow onset
nostril daily; maximum 200 nosebleeds. (7–14 days for
$$$ µg/day maximal effect).
Drug may fail to reach
the site of action if
excessive nasal
mucus secretion or
edema of the nasal
mucosa is present.
May use a
vasoconstrictor
(intranasal
decongestant) 2–3
days prior to the
suspension.
turbinates and away
from septum. Liquid
forms may be more
effective than
metered-dose
inhalers.
Initial priming needed.
Effects
flunisolide Adults: 2 sprays (25 Burning or Use at regular

generics µg/metered spray) in each stinging, intervals. Slow onset
nostril BID, may increase to nosebleeds. (7–14 days for
$$ TID if needed; maximum 300 maximal effect).
µg/day Drug may fail to reach
Children 6–14 y: 1 spray in the site of action if
each nostril TID; maximum excessive nasal
150 µg/day mucus secretion or
edema of the nasal
mucosa is present.
May use a
vasoconstrictor
(intranasal
decongestant) 2–3
days prior to the
suspension.
turbinates and away
from septum. Liquid
forms may be more
effective than
metered-dose
inhalers.
fluticasone Adults and children ≥12 y: 2 Burning or Use at regular

propionate sprays (50 µg/spray) in each stinging, intervals. Slow onset
Flonase, generics nostril daily, may increase to nosebleed. (7–14 days for
BID in severe situations; May cause maximal effect).
$$$ maximum 400 µg/day mild growth Drug may fail to reach
Children 4–11 y: 1–2 sprays suppression the site of action if
in each nostril daily; with prolonged excessive nasal
maximum 200 µg/day use.45,46,47 mucus secretion or
edema of the nasal
mucosa is present.
May use a
vasoconstrictor
(intranasal
decongestant) 2–3
days prior to the
suspension.
turbinates and away
from septum. Liquid
forms may be more
effective than
metered-dose
inhalers.
Effects
fluticasone furoate Adults and children ≥12 y: 2 Burning or Use at regular

Avamys sprays (27.5 µg/spray) in stinging, intervals. Slow onset
each nostril once daily; nosebleeds. (7–14 days for
$$$ maximum 110 µg/day maximal effect).
Children ≥2 y to <12 y: 1 Drug may fail to reach
spray in each nostril once the site of action if
daily, may increase to 2 excessive nasal
sprays in each nostril once mucus secretion or
daily if needed. Decrease to edema of the nasal
1 spray in each nostril daily mucosa is present.
for maintenance; maximum May use a
110 µg/day vasoconstrictor
(intranasal
decongestant) 2–3
days prior to the
suspension.
turbinates and away
from septum. Liquid
forms may be more
effective than
metered-dose
inhalers.
Initial priming needed.
Re-prime if not used
≥30 days or if cap left
off for ≥5 days.
mometasone Adults and children ≥12 y: 2 Burning or Use at regular

Nasonex sprays (50 μg/spray) in each stinging, intervals. Slow onset
nostril daily, may decrease nosebleeds. (7–14 days for
$$$ to 1 spray in each nostril maximal effect).
daily for maintenance; may Drug may fail to reach
increase to BID in severe the site of action if
situations. excessive nasal
Children 3–11 y: 1 spray in mucus secretion or
each nostril daily edema of the nasal
mucosa is present.
May use a
vasoconstrictor
(intranasal
decongestant) 2–3
days prior to the
suspension.
turbinates and away
from septum. Liquid
forms may be more
effective than
metered-dose
inhalers.
Effects
triamcinolone Adults and children ≥12 y: 2 Burning or Use at regular

Nasacort AQ sprays (55 µg/spray) in each stinging, intervals. Slow onset
nostril once daily, may nosebleeds. (7–14 days for
$$$ decrease to 1 spray in each maximal effect).
nostril once daily Drug may fail to reach
Children 4–11 y: 1 spray (55 the site of action if
µg/spray) in each nostril excessive nasal
once daily, may increase to 2 mucus secretion or
sprays in each nostril once edema of the nasal
daily if needed. Decrease to mucosa is present.
1 spray in each nostril daily May use a
for maintenance; maximum vasoconstrictor
110 µg/day (intranasal
decongestant) 2–3
days prior to the
suspension.
turbinates and away
from septum. Liquid
forms may be more
effective than
metered-dose
inhalers.
Drug Class: Decongestants
oxymetazoline Adults and children ≥6 y: Burning, Onset of action: 5–10

Claritin Allergy 0.05% solution 2–3 drops or stinging, min.
Decongestant, sprays/nostril Q12H sneezing, Long duration of
Dristan Long Lasting dryness of the action lasting up to 12
Nasal Mist, Dristan nasal mucosa. h.
Long Lasting Bradycardia, Do not use longer than
Mentholated Nasal tachycardia, 3–5 days.
Spray hypotension
and
$ hypertension
have been
reported.
phenylephrine Adults and children ≥6 y: Burning, Onset of action: 5–10

Dristan Nasal Mist 0.25% or 0.5% solution 2–3 stinging, min.
drops or sprays/nostril Q4H sneezing, Long duration of
$ dryness of the action lasting up to 12
nasal mucosa. h.
Bradycardia, Do not use longer than
tachycardia, 3–5 days.
hypotension
and
hypertension
have been
reported.
Effects
xylometazoline Adults and children ≥6 y: Burning, Onset of action: 5–10

Otrivin, Balminil 0.05% or 0.1% solution 2–3 stinging, min.
Nasal Decongestant drops or 1–2 sprays/nostril sneezing, Long duration of
Q8-10H dryness of the action lasting up to 12
$ nasal mucosa. h.
Bradycardia, Do not use longer than
tachycardia, 3–5 days.
hypotension
and
hypertension
have been
reported.
Drug Class: Mast Cell Stabilizers
sodium cromoglycate Adults and children >2 y: 1 Local: Less effective than
Rhinaris CS Anti- spray/nostril 3–6 times daily Sneezing, other agents.
allergic nasal stinging Onset of action
or irritation, delayed up to 4 wk.
$$ bad taste in
the mouth,
epistaxis.
a Cost of 1 unit (spray pump); includes drug cost only.
Legend: $ < $10 $$ $10–20 $$-$$$ $10–30 $$$ $20–30
Suggested Readings
Brozek JL, Bousquet J, Baena-Cagnani CE et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines:
2010 revision. J Allergy Clin Immunol 2010;126:466-76.
Seidman MD, Gurgel RK, Lin SY et al. Clinical practice guideline: Allergic rhinitis. Otolaryngol Head Neck Surg
2015;152:S1-43.
Wallace DV, Dykewicz MS, Bernstein DI et al. The diagnosis and management of rhinitis: an updated practice
parameter. J Allergy Clin Immunol 2008;122:S1-84.
Wheatley LM, Togias A. Clinical practice. Allergic rhinitis. N Engl J Med 2015;372:456-63.
References
1. Mucci T, Govindaraj S, Tversky J. Allergic rhinitis. Mt Sinai J Med 2011;78:634-44.

2. Plaut M, Valentine MD. Clinical practice. Allergic rhinitis. N Engl J Med 2005;353:1934-44.
3. Brozek JL, Bousquet J, Baena-Cagnani CE et al. Allergic Rhinitis and its Impact on Asthma (ARIA)
guidelines: 2010 revision. J Allergy Clin Immunol 2010;126:466-76.
4. Greiner A, Hellings PW, Rotiroti G et al. Allergic rhinitis. Lancet 2011;378:2112-22.
5. Kay AB. Allergy and allergic diseases. First of two parts. N Engl J Med 2001;344:30-7.
6. Wallace DV, Dykewicz MS, Bernstein DI et al. The diagnosis and management of rhinitis: an updated
practice parameter. J Allergy Clin Immunol 2008;122:S1-84.
7. Scadding GK, Durham SR, Mirakian R et al. BSACI guidelines for the management of allergic and non-
allergic rhinitis. Clin Exp Allergy 2008;38:19-42.
Allergic Rhinitis—What You Need to Know
Allergic rhinitis is a condition caused by allergens in the air. Allergens are things that cause allergies. Some of the symptoms
of allergic rhinitis are sneezing, coughing, runny nose, and itchy or watery eyes. The most important thing you can do to feel
better is to avoid the things that cause your allergies. Also avoid exposure to cigarette smoke and strong smells. If you do not
know what causes your allergies, see your doctor.
Helpful Hints for People Who Have Allergies
If you are allergic to pollen:
Keep the windows and doors of your house closed.

If you need to use air conditioning, set the unit to the indoor cycle.
Do not use window or attic fans.
Check the weather report to find out about the pollen count. The pollen count tells you what kind of pollen is in
the air and how much. Avoid spending time outdoors when the pollen count is high. The pollen count is highest
on sunny, windy days and in the morning.
Do not dry your clothing outdoors.
Shower or take a bath and wash your hair after outdoor activity. This will remove pollen from your hair and skin.
You want to avoid getting pollen into your bedding.
If you are allergic to outdoor moulds:
Stay indoors as much as possible.

If you need to use air conditioning, set the unit to the indoor cycle. Have your air conditioner cleaned regularly.
Air conditioners can be heavily contaminated with mould.
Use a facemask if you rake leaves or work with compost or dry soil.
If you are allergic to indoor moulds:
Kill mould with a solution of equal parts household bleach and water. Wash sinks, shower stalls, nonrefrigerated
vegetable storage areas and garbage pails with this solution.
Avoid using a humidifier or cool mist vaporizer. Moulds grow easily where it is damp. If you must use a
humidifier or vaporizer, clean it often with a solution of equal parts bleach and water.
If your home is built over a crawl space, install a plastic vapor barrier over exposed soil and keep the foundation
vents open.
If your basement is damp or tends to flood, do not put carpet or furniture there. For a damp basement, run a
dehumidifier at all times. Empty water from the machine often and clean it regularly. For a flooded basement,
drain the water as quickly as possible.
Fix any leaky faucets or pipes promptly.
Do not keep houseplants.
If you are allergic to dust mites:
Do not put carpet in your bedroom or main living areas.

Plastic, leather or wood furniture is best.
If possible, have someone else clean the house while you are not at home.
If you must do your own cleaning, wear a facemask while you clean and for 10–15 minutes afterward.
Use a vacuum cleaner with an efficient double-filtration system.
Keep indoor humidity between 40% and 45%. You can buy a hygrometer to measure the humidity in your house
at a hardware store or home centre.
Avoid using a humidifier or cool mist vaporizer.
Use zippered, allergen-proof casings on all mattresses, box springs and pillows.
Consider replacing old mattresses.
Wash your bedding in hot (>55°C) water at least every 2 weeks. Cooler water will not kill dust mites.
Do not keep stuffed toys that cannot be washed.
Do not store items under your bed.
Use window shades instead of venetian blinds.
If you are allergic to a pet:
The best choice is to find another home for the animal. It can take several months before the allergen levels
return to normal.
If you are not able to give up your pet, then:
You may find it helps to install a HEPA or electrostatic air purifier in your home.
Keep animals out of your bedroom at all times.
Keep animals out of rooms that have carpets.
Try to keep animals off furniture.
Washing cats weekly and dogs twice weekly may help, though this has not been proven.
Get rid of litter boxes if possible. If not, put them in an area that is not connected to the air supply for the
rest of your home.
If the animal lives in a cage, keep it in a room without carpet, far away from your bedroom.
Medication to Help with Allergy Symptoms
You may want to try medication if:
You don't feel better even when you avoid the things that cause your allergies.
Your allergies are interfering with your sleep or your daily activities.
Your pharmacist can help you pick the best medication for you and show you how to use it. See Table 1. You can choose
between pills or a nasal spray.
Table 1: How to Use a Nasal Spray or Drops

Nasal Spray (Adults only)
1. Gently blow your nose.

2. Gently shake bottle and remove cap or lid.
3. With your head upright but not tilted backward, press your finger against one side of your nose to
close the nostril. Spray the medication into the open nostril, with the tip directed away from the
middle of the nose and back towards the nasal cavity. Squeeze the bottle quickly and breathe in
slowly through the nose.
4. Remove tip of nasal spray from your nostril and breathe out through your mouth.
5. Do the same thing on the other side.
6. Blow your nose in 3–5 minutes.
7. Rinse the tip of the spray bottle with hot water, but try not to get water in the bottle. Replace lid.
8. Do not use more nose spray than the recommended amount.
Nose Drops (Adult or child)
1. Gently blow your nose.

2. Lie on your back on a bed with your head hanging slightly over the side.
3. Gently shake bottle. Fill the dropper with the recommended amount of medication. Put the dropper
just inside one nostril (about 0.8 cm or one-third inch). If possible, don't let the dropper touch the skin.
4. Apply the recommended number of drops. Apply the medication to the other nostril in the same way.
5. Stay in the same position for about 5 minutes. Tilt head from side to side.
6. Blow the nose 3–5 minutes later.
7. You can also take nose drops by tilting your head back (instead of lying down). Use the
recommended number of drops for each nostril. Then bend over at the waist and hold that position
for a few seconds before coming up straight again.
8. Rinse the dropper with hot water and return it to the bottle.
9. Do not use nose drops more than is recommended on the package.
this information. Once printed there is no quarantee the information is up-to-date. [Printed on: 04-05-2018 08:29 AM]
Assessment of Patients with Upper Respiratory Tract Symptoms

Introduction
Upper respiratory tract infection is a nonspecific term used to describe a spectrum of acute infections that may
involve the nose, sinuses, pharynx, larynx and trachea. These infections are common in adults and children and
may be caused by a virus, by bacteria or (less frequently) by fungi. Most viral infections are self-limited, resolve
spontaneously and are managed symptomatically. Some patients are at risk of complications of viral infections
including influenza (see Table 1) and respiratory syncytial virus and may require specific antiviral treatment.
Bacterial infections or complications should be medically evaluated to determine the need for antibiotic therapy
and further specific intervention.
Patient Assessment
Viral and bacterial infections can be difficult to differentiate. Signs and symptoms, along with a medical history,
can help determine the next steps of care (see Figure 1). Investigation for possible bacterial infection is indicated
in the presence of fever lasting more than 72 hours, high fever, chills, severe sudden throat pain, prolonged
congestion (>7 days), difficulty breathing, earache (especially in children) or double sickening (worsening after a
few days of initial improvement). The patient should be assessed for the presence of complications, intensity of
care required and the need for antibiotics.
Patients suffering from the common cold usually first complain of discomfort of the throat (dryness, scratchiness),
followed by nasal congestion and rhinorrhea. Nasal discharge is clear and watery at the beginning and becomes
mucopurulent as the infection progresses. Cough may be present and may persist for 1–2 weeks. Usually dry at
the beginning, the cough often becomes productive.
Compared with the common cold, the onset of throat pain in pharyngitis is more rapid and the pain is more severe.
Prolonged nasal congestion and purulent drainage are consistent with possible sinusitis; especially if
accompanied by fever, headache and facial pain.
Cough is present in most upper respiratory tract infections, such as the common cold and influenza, but may be
caused by many other conditions, many of which require diagnosis by an appropriate healthcare practitioner (see
Acute Cough, Table 1). Cough persisting longer than 3 weeks should be assessed more thoroughly.
See Table 2 for a comparison of common upper respiratory tract ailments. For more detailed information, see Viral
Rhinitis, Influenza, Sinusitis and Pharyngitis. Symptoms suggestive of croup, epiglottitis or otitis media (see Table
3) require further assessment for a tailored workup and treatment.
Allergic rhinitis can resemble the common cold but does not have an infectious etiology. Allergic rhinitis is
characterized by sneezing and rhinorrhea which may progress to nasal congestion. Eye symptoms, such as
conjunctivitis and lacrimation may also be present. See Conjunctivitis and Allergic Rhinitis.
1
Table 1: Persons at High Risk of Complications or Hospitalization Due to Influenza
Adults and children with chronic conditions, such as cardiac or pulmonary disorders, diabetes
mellitus or other metabolic disease, cancer, immunodeficiency or immunosuppression, renal
disease, anemia or hemoglobinopathy, morbid obesity (BMI ≥40)
Any resident of a nursing home or other chronic care facility, regardless of age
Persons 65 years of age and older
Conditions that compromise the management of respiratory secretions and are associated with an
increased risk of aspiration
Children and adolescents with conditions treated for long periods with acetylsalicylic acid
Healthy children under 5 years of age
Pregnant women
Aboriginal persons
Table 2: Differential Diagnosis of Upper Respiratory Tract Conditions
Symptom/Cause Common Allergic Influenza6,7,8 Sinusitis6,7,8,12,13 Pharyngitis6,7,8,14
Cold2,3,4,5,6,7,8 Rhinitis9,10,11
Nasal discharge Clear at the Abundant; Clear at the Persistent, purulent Rare
and congestion beginning, then aqueous and beginning, rhinorrhea
can become clear then Coloured (yellow,
mucopurulent Nasal mucopurulent green)
Nasal congestion Nasal
congestion is may be congestion is
common present rare
Fever Rare, mild No Yes (38–40°C) Possible Yes

Sudden onset
Sore throat Common Rarely Sometimes No Severe, sudden

Mild (dry, onset
scratchy, sore)
Cough Mild to Possible via Common Possible via Rare

moderate post-nasal drip Nonproductive postnasal drip
Dry at the
beginning; often
becomes
productive as
the cold
progresses
Headache Rare, via sinus Via sinus Yes Common, via sinus
congestion congestion congestion
General aches Rare, mild Earaches, Common Rare Possible

and pain especially in (myalgia)
children
Other Sneezing in the Pruritus Fatigue, Facial tenderness;

first couple of (palate, nose, weakness, jaw and tooth pain
days eyes) chills
Sneezing,
lacrimation
Duration Usually 5–7 As long as 10 days Days to weeks 3 days

days but 25% exposed to the
last 14 days allergen
Etiology Viral Noninfectious Viral Viral, bacterial, Viral (most

fungal (rare) common), bacterial
Table 3: Croup, Epiglottitis and Otitis Media in Children

Condition Croup6,15,16 Epiglottitis6,16 Otitis Media6,17
Condition Croup Epiglotittis Otitis media
Possible signs Barking, seal-like cough, Sore throat and difficulty Fever, especially one
and symptoms usually nonproductive swallowing beginning several days
Gradually worsening Fever, chills after the start of a cold
inspiratory stridor Stridor Earache or child tugging
Dyspnea at or fingering ear
Use of accessory muscles
Fever and positioning for Irritability and/or lethargy
Hoarseness breathing (laboured, Purulent drainage from

sitting upright, and leaning ear
slightly forward)
Hoarseness
Drooling
Cyanosis
Other Fluctuating course with Rapidly progressive, For more information,

characteristics rapid improvements and usually absence of cough consult the Compendium
declines; symptoms often of Therapeutic Choices:
worse at night Acute Otitis Media in
Prodrome (2–5 days) Childhood.
consisting of mild fever,
rhinorrhea, malaise, sore
throat and cough
For more information,
consult the Compendium
of Therapeutic Choices: .
Algorithms
2,3,4,5,6,7,8,9,10,11,12,13,14
Figure 1: Assessment of Patients with Upper Respiratory Tract Symptoms
Stridor is a
high-pitched,
wheezing
sound caused
by disrupted
airflow.
Child?
a See Allergic Rhinitis.

b See Viral Rhinitis, Influenza, Sinusitis and Pharyngitis.
c See Acute Cough.
d Antitussives are not recommended in children <6 years. See Acute Cough.
e First-generation antihistamines are not recommended in children <6 years. See Viral Rhinitis, Influenza, Sinusitis and
Pharyngitis.
Suggested Readings
Allan GM, Arroll B. Prevention and treatment of the common cold: making sense of the evidence. CMAJ
2014;186:190-9.
Committee on Infectious Diseases, American Academy of Pediatrics. Principles of appropriate use for upper
respiratory tract infections. In: Pickering LK, ed. Red Book: 2012 report of the Committee on Infectious Diseases.
29th ed. Elk Grove Village: American Academy of Pediatrics; 2012. p. 802-5.
Small P, Kim H. Allergic rhinitis. Allergy Asthma Clin Immunol 2011;7:S3.
References
1. National Advisory Committee on Immunization (NACI). An Advisory Committee Statement (ACS). Canadian
Immunization Guide chapter on influenza and statement on seasonal influenza vaccine for 2015-2016.
Ottawa (ON): PHAC; 2015. Available from: www.phac-aspc.gc.ca/naci-ccni/flu-2015-grippe-eng.php.
Accessed November 20, 2015.
2. Heikkinen T, Jarvinen A. The common cold. Lancet 2003;361:51-9.
3. Pratter MR. Cough and the common cold: ACCP evidence-based clinical practice guidelines. Chest
2006;129:72S-74S.
4. Canadian Paediatric Society. Caring for Kids. Colds in children. Available from:
www.caringforkids.cps.ca/handouts/colds_in_children. Accessed November 20, 2015.
5. Irwin RS, Madison JM. The diagnosis and treatment of cough. N Engl J Med 2000;343:1715-21.
6. Committee on Infectious Diseases, American Academy of Pediatrics. Principles of appropriate use for
upper respiratory tract infections. In: Pickering LK, ed. Red Book: 2012 report of the Committee on Infectious
Diseases. 29th ed. Elk Grove Village: American Academy of Pediatrics; 2012. p. 802-5.
7. Frei C, Frei B. Upper respiratory tract infections. In: DiPiro JT et al., eds. Pharmacotherapy: a
pathophysiologic approach. 9th ed. New York: McGraw-Hill Medical; 2014. p. 1717-29.
8. Nahata MC, O'Mara NB, Benavides S. Viral infections. In: Koda-Kimble MA, Young LL, eds. Applied
therapeutics: the clinical use of drugs. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2009. p. 72-1-72-
20.
9. May JR, Smith PH. Allergic rhinitis. In: DiPiro JT et al., eds. Pharmacotherapy: a pathophysiologic approach.
9th ed. New York: McGraw-Hill Medical; 2014. p. 1541-53.
10. Plaut M, Valentine MD. Clinical practice. Allergic rhinitis. N Engl J Med 2005;353:1934-44.
11. Small P, Kim H. Allergic rhinitis. Allergy Asthma Clin Immunol 2011;7:S3.
12. Desrosiers M, Evans GA, Keith PK et al. Canadian clinical practice guidelines for acute and chronic
rhinosinusitis. Allergy Asthma Clin Immunol 2011;7:2.
13. Worrall G. Acute sinusitis. Can Fam Physician 2011;57:565-7.
14. Worrall G. Acute sore throat. Can Fam Physician 2011;57:791-4.
15. Worrall G. Croup. Can Fam Physician 2008;54:573-4.
16. Sobol SE, Zapata S. Epiglottitis and croup. Otolaryngol Clin North Am 2008;41:551-66.
17. Canadian Paediatric Society. Management of acute otitis media. Paediatr Child Health 2009;14:457-64.
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients. Once
printed there is no quarantee the information is up-to-date. [Printed on: 09-08-2017 10:18 AM]
Viral Rhinitis, Influenza, Sinusitis and Pharyngitis

Introduction
Upper respiratory tract infections (URTIs) are a group of diseases of the upper airway caused by many
different viruses or bacteria. Each infection shares some common symptoms, involving, to variable degrees,
sneezing, nasal congestion and discharge (rhinorrhea), sore throat, cough, low grade fever, headache and
malaise. This chapter describes each infection and their symptomatic management.
Pathophysiology
Viral Rhinitis (Common Cold)
The common cold is a viral infection caused by more than 200 different viruses. Among these,
rhinoviruses (30–50%) are the most common in all age groups. More than 100 serotypes of rhinovirus
have been identified. Coronaviruses are also frequently involved, accounting for 10–20% of infections.
Other common viruses are respiratory syncytial virus (RSV), adenovirus, parainfluenza and
enterovirus.1,2,3
The common cold is one of the most common infectious diseases of humankind. Preschool children
average 6 episodes annually and adults 2–3.2 Daycare attendance is an important risk factor for
children.1 It is estimated that 40% of time lost from work and 30% of absences from school are due to
the common cold.1,4,5 It can occur at any time of year but is less common during the summer months.
Rhinoviruses are more prevalent during fall and spring, and coronaviruses during mid-winter and early
spring.1
The transmission of viruses that cause upper respiratory tract infection can occur by any of the following
3 mechanisms:1
hand contact with secretions that contain the virus, either directly from an infected person or
indirectly from environmental surfaces
small-particle aerosols lingering in the air
direct hit by large-particle aerosols from an infected person.
All 3 mechanisms are possible for each virus but the primary routes of transmission may differ between
them. Hand-to-hand contact appears to be the major transmission route for rhinovirus infection.
Contact between the virus and nasal mucosa appears to be important for initiation of the infection. The
increase in vascular permeability, glandular secretion and vasodilatation that follows are responsible for
the symptoms.1,3 The detailed mechanisms by which viral infection causes such changes in the nasal
mucosa are still incompletely understood.1 The host's humoral and cellular immune responses seem to
play pivotal roles. Cholinergic stimulation leads to increased mucous gland secretion and sneezing. No
increase in histamine concentration is noted.1 Viral replication peaks in 48 hours but viral shedding can
continue for up to 3 weeks.1
The common cold is characterized by a sore throat usually resolving within a few days, followed by nasal
congestion, rhinorrhea, sneezing and cough. Nasal discharge can sometimes be purulent and mistaken
for bacterial sinus infection.4 Fever is infrequent in adults but common in children.5 Symptoms peak
around 2–4 days and begin to resolve by day 7. For a small proportion of patients, symptoms such as
cough can still be present after 3 weeks.
The common cold is usually a self-limiting illness confined to the upper respiratory tract.1 It can
sometimes predispose individuals to bacterial complications, such as otitis media (especially in children
via dysfunction of the eustachian tube6), bacterial rhinosinusitis and pneumonia. It may also cause
exacerbations of asthma.1
Influenza
Influenza in humans is caused by influenza A and/or B virus. Influenza A viruses are categorized into
subtypes on the basis of 2 surface antigens, hemagglutinin and neuraminidase. Influenza B viruses are
separated into 2 distinct genetic lineages but are not categorized into subtypes.7 Immunity to 1 subtype
does not confer protection against another subtype, and mutations occur often.8 Although influenza A is
more common and tends to cause more severe illness, it is impossible to differentiate clinically between
influenza A and B.9,10
Influenza is normally seen between November and April in the northern hemisphere. Debate exists as to
how influenza virus is transmitted: airborne, droplet, contact or a combination of these.11 The incubation
period for influenza virus averages 2 days.7 Viral replication occurs in the superficial epithelium of the
airway tract. Symptoms, usually having an abrupt onset, are related to the presence of the virus in the
airway or to the host immune response. Initial symptoms tend to be systemic in nature, with respiratory
symptoms becoming prominent as systemic symptoms subside.12 Common systemic symptoms
include fever, myalgia, headache, malaise and chills. Respiratory symptoms include sore throat,
nonproductive cough and rhinitis.12 The infectivity period starts before the onset of symptoms and
usually lasts 5–7 days, but shedding of the virus may continue for 7 days or longer after the start of
symptomatic illness, especially in children and immunocompromised patients.13 Complications of
influenza include pneumonia and even death. Influenza may worsen chronic obstructive pulmonary
disease, asthma and pulmonary conditions of patients with cystic fibrosis. In 2011, influenza and
pneumonia together were responsible for 5767 deaths and ranked 8th among leading causes of death in
Canada.14 Persons at high risk of experiencing complications due to influenza are described in
Assessment of Patients with Upper Respiratory Tract Symptoms, Table 1.
For more information, consult the Compendium of Therapeutic Choices: Influenza.
Rhinosinusitis or Sinusitis
Acute rhinosinusitis is characterized by inflammation of the nasal cavity and paranasal sinuses in
response to infection, that lasts less than 4 weeks.15,16 Symptoms include nasal congestion and
obstruction, purulent nasal discharge, maxillary tooth discomfort and facial pain or pressure, hyposmia
or anosmia, cough, headache, fever and malaise.17
Rhinosinusitis is often preceded by a viral upper respiratory tract infection. Viral and bacterial infections,
as well as allergic rhinitis, affect mucociliary transport thereby disrupting evacuation of microorganisms.
Although it is often preceded by a viral upper respiratory tract infection, only 0.5–2% of episodes of viral
rhinosinusitis are complicated by acute bacterial infection.18 The most common viruses are rhinovirus,
influenza virus and parainfluenza virus. Streptococcus pneumoniae or Haemophilus influenzae cause 70%
of bacterial rhinosinusitis.16 Moraxella catarrhalis is also a common pathogen in children.19,20 Other
events that introduce microorganisms into the sinuses (such as dental extraction) or anatomical
abnormality may also be precipitants.
Complications of acute rhinosinusitis include periorbital and orbital cellulitis, orbital abscess, blindness
and cavernous sinus thrombosis.20 Complications of chronic rhinosinusitis can include mucoceles
(airless, expanded sinuses) and nasal polyps.20
Rhinosinusitis is considered chronic if symptoms persist more than 3 months. Risk factors for
developing chronic rhinosinusitis include: anatomical abnormalities (e.g., deviation of the nasal septum,
Most cases of rhinosinusitis are viral and are self-limiting. Differentiating bacterial from viral
rhinosinusitis is a challenge because the clinical features of the 2 etiologies are similar.18 A change in
the colour of the nasal discharge is not a specific sign of bacterial infection since mucopurulent nasal
secretions may also occur a few days after onset of a viral infection.18 Bacterial rhinosinusitis is
suggested when sinus symptoms do not improve within 10 days or worsen after 5–7 days, and by the
presence of nasal obstruction or purulence plus one or both of facial pain/pressure/fullness or
hyposmia/anosmia.15,18 These patients should be assessed for antibiotic therapy. Other symptoms
(e.g., headache, dental pain, cough, halitosis) may be present but are not used for the diagnosis of acute
bacterial rhinosinusitis.
Pharyngitis
A sore throat is common to many URTIs and usually does not require specific treatment. Symptoms
suggestive of GABHS include sore throat with a sudden onset, fever and headache. Nasal congestion,
conjunctivitis and cough are not generally suggestive of bacterial pharyngitis.25 After eliminating other
causes of sore throat, a modified Centor score can be used to help determine the likelihood of GABHS
and therefore the need for antibiotic treatment.26,27 The score is determined using the criteria listed in
Table 1. If the cumulative score is ≥2 points, refer the patient for culture and possibly antibiotics. The
score is not a diagnostic tool and should not be relied upon as such. As many as 25–30% of all GABHS-
positive culture results in adults with pharyngitis occur in those with a modified Centor score of less than
2.26 Conversely, up to 50% of patients with a score of ≥4 may have a GABHS-negative throat culture
result and not need antibiotic treatment.
If a patient with a sore throat also presents with painful dysphagia, they should be assessed for the
presence of epiglottitis.
27
Table 1: Modified Centor Score
Criteria Points
Temperature >38°C 1
Absence of cough 1
Swollen, tender anterior cervical nodes 1
Tonsillar swelling or exudate 1
Age
3–14 years 1
15–44 years 0
≥45 years −1
Adapted with permission from McIsaac WJ, White D, Tannenbaum D, Low DE. A clinical score to reduce unnecessary antibiotic use in
patients with sore throat. CMAJ 1998;158:75-83. Copyright © 1998 Canadian Medical Association.
Prevention
Upper respiratory tract viruses are transmitted by direct contact (hand-to-hand), aerosol particles or contact
with settled droplets. Routine handwashing is recommended to prevent transmission of infection.1,28 One
should also try not to touch the face and eyes. Proper handwashing technique is described in Common Cold
and Influenza—What You Need to Know at the conclusion of this chapter. Alcohol-based hand sanitizers are
widely used in healthcare settings or in situations when water is not available but may be of limited value for
preventing spread of respiratory infections.29,30 Handwashing remains the first and most important step for
cleaning hands, especially if they are visibly soiled. Hand sanitizers are to be used as a supplement to
regular, effective handwashing, when water is not readily available, and when hands are not visibly soiled.
Sneeze and cough etiquette is another method traditionally advised for the prevention of URTIs. This
involves coughing or sneezing into an arm, sleeve or tissue. If a tissue is used, it should be promptly thrown
away and the hands washed.31
Prevention of Influenza
Annual influenza vaccination is the most effective way to prevent influenza and its complications. Health
Canada has approved trivalent and quadrivalent vaccines, most of which are inactivated, but one live
attenuated quadrivalent vaccine is available. Refer to current statement from the National Advisory
Committee on Immunization (NACI) for details regarding yearly vaccine availability.32 The vaccines are
modified each year according to the viruses expected to circulate in the population that season. The
efficacy of the vaccine depends on the degree of antigenic match between the vaccine virus and the
circulating virus. Influenza vaccine can provide moderate protection against influenza, but protection is
greatly reduced or absent in some seasons.33 Healthy school-age children and adults respond well to
vaccination, whereas preschool children, the elderly and the immunocompromised respond less
well.32,34,35 The live-attenuated influenza vaccine provides improved efficacy compared with inactivated
vaccines in children ≤6 years but should be avoided in certain populations (those <2 years or >59 years
of age, pregnant women, those with immunodeficiencies, severe asthma or egg allergy, or children
receiving ASA therapy).32 With a good antigenic match, influenza vaccination prevents influenza in 56–
91% of healthy children and adults. Protection is lower in elderly and immunocompromised patients.32
Vaccination also reduces rates of illness, numbers of physician visits and sick days in healthy, working
adults. Protection is generally achieved approximately 2 weeks after vaccine administration, and usually
lasts less than 1 year.
Vaccination is encouraged for all appropriate candidates but is particularly important for those at high
risk of complications due to influenza (Assessment of Patients with Upper Respiratory Tract Symptoms,
Table 1). It is also recommended for people capable of transmitting influenza to those at high risk, such
as healthcare workers and household contacts (including children) of people at high risk who either
cannot receive the vaccine or may respond inadequately to it (e.g., elderly, immunocompromised, infants
<6 months), those providing regular care to children <5 years of age, or persons who provide essential
community services.32,36
The optimal time for vaccination is mid-October to mid-November. However, if this time frame is missed,
vaccination should be performed at any opportunity that becomes available prior to the end of the flu
season, typically the end of April in Canada.32 The inactivated vaccine is safe in all stages of pregnancy
and during breastfeeding.32
Antiviral chemoprophylaxis is no longer recommended other than in select circumstances, such as

control of outbreaks in long-term care facilities that house large numbers of patients at high risk of
influenza complications.24 In other circumstances, the preferred approach is early treatment of infected
persons because of the potential risk of oseltamivir resistance emerging during postexposure
prophylaxis (see Table 2).
24
Table 2: Recommendations for Chemoprophylaxis vs. Early Therapy for Influenza
In general, early treatment of symptomatic illness is recommended in preference to
postexposure prophylaxis after contact with infectious individuals.
In exposed, susceptible, profoundly immunosuppressed individuals at very high risk of

complications, presumptive treatment should be initiated prior to the onset of symptomatic
illness.
Prophylaxis, combined with treatment for ill persons, is indicated to control outbreaks in nursing
homes and other long-term care facilities where large numbers of patients are at high risk of
acquiring infections due to their housing arrangements and influenza complications.
Neither early treatment nor prophylaxis should be prescribed:

for groups of healthy individuals based on possible exposure in the community
if the close contact did not occur during the infectious period of the person with suspected
or confirmed influenza
If >4 days have elapsed since the last infectious contact.
For the common cold, influenza, pharyngitis and rhinosinusitis, nonpharmacologic treatment consists of bed
rest, good hydration and increased humidity (>50%).
Irritated nasal tissue may be soothed with commercial nasal saline solutions. Nasal saline can improve
symptoms and decrease medication use in rhinosinusitis.37 Petrolatum may be applied to a raw nose to
increase patient comfort.
Acetaminophen and NSAID are used in upper respiratory conditions to reduce associated headaches, pain
and fever. Usual analgesic/antipyretic doses are used. They do not alter viral shedding or antibody
response.38,39 ASA should not be used in children and adolescents with viral illnesses due to its association
with Reye's syndrome.
Ailments—Analgesic Products: Internal Analgesics and Antipyretics; Cough, Cold and Allergy Products.
Viral Rhinitis
Symptomatic treatment remains the mainstay of managing the common cold, because there is no
effective antiviral cure and few effective preventive measures. The literature on the common cold is
extensive, but inconsistent in its rigour. These limitations restrict the ability to make confident and
specific recommendations about treatments.
Agents used to treat symptoms of viral rhinitis include decongestants (topical and oral) alone or in
combination with antihistamines. For treatment of an accompanying cough see Acute Cough.
Decongestants
Decongestants are sympathomimetic agents that can relieve nasal congestion associated with the
common cold, influenza and rhinosinusitis. They are available in oral and topical formulations.
Several systematic reviews including studies that evaluated systemic and topical decongestants, in
single or repeat doses, have evaluated the efficacy of decongestants.40,41,42 Single doses of nasal
decongestants are moderately effective in relieving nasal congestion due to the common cold in
adults. The multiple dosing studies are conflicting; some show benefit while others do not. Given
these results, the use of topical or oral decongestants for a few days is reasonable and consistent
with standard practice.2
There is no published evidence that decongestants are effective in children under 12 years of
age.40,43
Decongestants used in the symptomatic management of upper respiratory tract infections are
described in Table 5. Side effects differ between oral and topical formulations. Oral decongestants
are generally not recommended in patients with hypertension. While most decongestants cause
blood pressure elevations in normotensive persons only at doses that significantly exceed the
recommended range, elevation of blood pressure may occur at standard doses in hypertensive
patients.44,45
Rhinitis medicamentosa refers to rebound vasodilation that occurs after prolonged regular use (3–5
days) of topical decongestants and results in nasal congestion when the topical agent is
discontinued. This condition is more likely to arise with shorter-acting agents (phenylephrine) than
with longer-acting agents (oxymetazoline, xylometazoline). Many treatments for this problem have
been proposed, including a slow reduction in use of the decongestant, a switch to inhaled
corticosteroid or an abrupt discontinuation of the topical decongestant. Abrupt cessation is effective
but is difficult because the patient will be congested for several days or weeks.46
Antihistamines
The efficacy of antihistamines in the management of the common cold is marginal at best because
histamine is not involved in the pathology of this infection. Due to their anticholinergic properties,
first-generation antihistamines may be minimally helpful in managing rhinorrhea associated with the
common cold.47,48 Antihistamines reduce overall symptoms compared with placebo for the first two
days of a cold but have no additional benefit beyond the first two days.49 There is concern that by
making mucus thicker, antihistamines may make secretions more difficult to expel, leading to
increased congestion of the nose and/or chest. This is also a concern if used to treat
rhinosinusitis.50 The adverse effect profile of the first-generation antihistamines must also be
considered as they generally outweigh the benefit.51
First-generation antihistamines may reduce cough associated with the common cold (see Acute
Cough).52,53 Second-generation antihistamines have no effect on symptoms of the common cold.
Antihistamines are not recommended for treatment of cough in children younger than 6 years old.
Menthol
Menthol has long been used for the treatment of congestion and cough associated with the common
cold. Menthol may increase the perception of nasal breathing; however, objective measurements of
nasal flow do not indicate improvement.54
Influenza
Symptomatic treatment is the usual management approach for influenza. Acetaminophen or NSAID can
help with the fever, aches and pain associated with influenza. ASA should not be used in children and
adolescents due to its association with Reye's syndrome. Antivirals can be of benefit if started rapidly
after the onset of symptoms and should be considered for patients at high risk of complications
(Assessment of Patients with Upper Respiratory Tract Symptoms, Table 1). See Fever, Table 5 for
information and dosing of medications used for fever and pain.
Prescription Therapy
Neuraminidase Inhibitors
Oseltamivir and zanamivir inhibit neuraminidase, an enzyme essential for the replication of influenza
(see Table 6). The neuraminidase inhibitors have fewer side effects than amantadine and are
effective against both influenza A and B. They prevent symptoms and shorten the duration of illness
by about 1 day if taken within 48 hours of the onset of symptoms.55,56,57,58,59,60 Evidence for or
against their benefit in preventing complications of seasonal influenza in otherwise healthy adults is
lacking.61 Oseltamivir may reduce mortality in high-risk populations.62 Resistance is rare among
currently circulating strains but may eventually emerge, especially if antivirals are misused.63
Amantadine
Amantadine is not used for treatment or prevention of influenza due to almost complete resistance
of circulating viruses.24
Rhinosinusitis
The majority of cases of acute rhinosinusitis will resolve on their own.18 Symptomatic treatment such as
saline nasal irrigation, decongestants (systemic and topical) and analgesics may be used to alleviate
the symptoms. There have been few rigorous studies of the effect of nonprescription treatments on the
symptoms of rhinosinusitis; available evidence suggests that the effect of these treatments is
minimal.19 In severe cases, nasal corticosteroids may be used.64 If secondary bacterial infection occurs,
antibiotics are required.
For further discussion of pharmacologic therapy for rhinosinusitis, consult the Compendium of
Therapeutic Choices: Acute Rhinosinusitis.
Pharyngitis
The pain associated with pharyngitis may be eased with systemic (e.g., acetaminophen, ibuprofen) or
local analgesics (e.g., benzocaine, diclonine hydrochloride, phenol). Local analgesics (anesthetics) are
available as lozenges, sprays and gargles and provide short-term relief (30–45 minutes).
Methemoglobinemia is an uncommon but serious adverse effect that has been reported with the use of
benzocaine applied to the oral mucosa.65 Some lozenges contain antiseptics (e.g., cetylpyridinium,
dequalinium); however, there is no evidence of benefit particularly since most cases of pharyngitis are
viral. Nonmedicated lozenges may reduce the discomfort of a sore throat by their demulcent effect on
the throat and their ability to increase salivation. Topical treatments should not be recommended if
severe pain upon swallowing and dysphagia is present. Abrupt closure/spasm of the epiglottis leading to
death has been reported with their use in the presence of epiglottitis.66
The objectives of antibiotic treatment for group A streptococcal infections are mainly to prevent
suppurative complications and rheumatic fever, and to decrease contagiousness.
For further discussion of pharmacologic therapy for pharyngitis, consult the Compendium of Therapeutic
Choices: Streptococcal Sore Throat.
Nonprescription agents used in the management of upper respiratory tract infections are described in
Table 5.
Ailments—Analgesic Products: Internal Analgesics and Antipyretics; Cough, Cold and Allergy Products.
Use of Combination Products
Selection of a combination product over a single-ingredient product is preferred for practical reasons
from a patient's perspective. Antihistamine-decongestant and antihistamine-decongestant-analgesic
combinations appear to have an impact on common cold symptoms.67 However, combination products
complicate dose tailoring of specific ingredients. Increasing the dose for a desired selected effect may
lead to toxic effects of another ingredient. It is also less flexible when trying to adapt choice of specific
ingredients to the continuously changing symptomatic picture over the course of an upper respiratory
tract infection.
Echinacea
Echinacea is hypothesized to stimulate the immune system and is widely used to prevent and treat
the common cold and other respiratory infections.68 Three species of echinacea are available:
Echinacea angustifolia, Echinacea purpurea and Echinacea pallida. E. purpurea is the most frequently
studied, but E. angustifolia is most commonly used in North America. Numerous studies have
evaluated the efficacy and safety of echinacea for this indication. Though it appears to be safe,
evidence regarding its efficacy is inconclusive.69,70 Several rigorously designed studies and meta-
analyses have failed to demonstrate a beneficial effect in prevention or treatment of upper respiratory
tract infections.
The dose that has been used is 1 g 3 times daily. Treatment begins at the first sign of symptoms and
continues at least 10–14 days.68 Echinacea is generally well tolerated. Adverse effects are
uncommon but have included allergy, nausea and dizziness, tingling of the tongue and excessive
salivation. Allergic cross-sensitivity can occur with members of the Asteraceae/Compositae family
(e.g., ragweed); echinacea should be used with caution in atopic individuals.71 It is contraindicated in
immunosuppressed patients, including those with HIV and autoimmune diseases or those taking
immunosuppressant medication. Safety in pregnancy or during breastfeeding has not been
established.
Garlic
Garlic demonstrates some antiviral and antibacterial activity possibly related to allicin, a compound
that is produced when garlic is chopped up. Allicin has been evaluated for prevention and treatment
of the common cold in several trials.72 However, given the poor quality of these trials, evidence is
insufficient to provide any recommendations on use of garlic.
North American Ginseng
A popular natural remedy for the prevention and treatment of the common cold is North American
ginseng (Panax quinquefolius). A systematic review found insufficient evidence that ginseng reduces
the incidence or severity of the common cold.73 However, ginseng reduced the duration of the
common cold by about 6 days if used daily for up to 4 months. The main side effect was GI upset.
There was great heterogeneity among a small number of trials in this systematic review. In addition,
results may be applicable only to healthy adults. The authors found no trials that evaluated ginseng
for the treatment of the common cold.
Vitamin C (Ascorbic Acid)
It is a popular belief that large doses of vitamin C can treat or prevent the common cold but there is
no reliable evidence to support this belief. Treatment with vitamin C at doses of ≥200 mg/day does
not have an impact on the duration or severity of the common cold in the general population.74 In
addition, daily use of vitamin C (1 g/day) does not reduce the incidence of the common cold in the
general population but may be of benefit in preventing colds in persons engaged in extreme physical
exercise and/or exposed to significant stress due to extreme cold temperatures.74
Prolonged intake of more than 1 g per day of vitamin C may cause oxaluria, uricosuria, renal stones or
diarrhea. Abrupt discontinuation of prolonged intake of >1 g per day may lead to rebound scurvy.
Zinc
Zinc (gluconate or acetate) lozenges have been purported to decrease the duration and severity of
the common cold. In vitro, zinc has the capacity to inhibit viral replication.75 However, evidence for its
efficacy in vivo is inconsistent and inconclusive.75,76,77,78,79,80 Meta-analyses also provide
conflicting results.81,82 Explanations for the divergent results include widely varying dosages,
inadequate blinding and bioavailability issues.
If zinc is used, the lozenge should contain at least 13.3 mg of elemental zinc, similar to lozenges
studied, and should be free of agents that chelate zinc and inhibit its absorption, such as citric acid
and tartaric acid.75 Treatment should begin within 48 hours of symptom onset. The dose is 1 lozenge
every 2 hours while awake for the duration of the cold. Common side effects are bad taste, mouth
irritation, nausea and diarrhea. Side effects and the frequency of dosing often lead to discontinuation
of therapy. Because of its potential to cause mouth irritation and gastric erosions, zinc should be
avoided in cases of aphthous or peptic ulcers. Zinc may decrease absorption of tetracyclines or
quinolones; avoid concomitant therapy. The use of intranasal zinc has been associated with long-
term or permanent loss of smell and is not recommended.80
Minor Ailments—Herbal and Natural Health Products: Single Entity; Vitamin and Mineral Products:
Single Entity.
Considerations in Special Populations
Children
Acetaminophen or ibuprofen may be used for relief of aches and pains or fever >38.5°C. Avoid ASA
due to its association with Reye's syndrome. See Fever for more information on the management of
fever.
Nonprescription cough and cold remedies should be avoided in children under 6 years of age.43,83 In
December 2008, Health Canada required manufacturers to relabel nonprescription cough and cold
medicines with certain active ingredients to indicate that they should not be used in children under 6
years.83 Active ingredients affected by Health Canada's decision on cough and cold products for
children include antihistamines, antitussives, expectorants and decongestants that are given orally
for treatment of the common cold (see Table 3). Medications given by a route of administration other
than oral or for another indication (e.g., antihistamine for allergic rhinitis) are not included in the
Health Canada advisory. Although cough and cold medicines have been used by children for many
years, little evidence supports their effectiveness in this group.40,49,84 In addition, reports of misuse,
overdose and, on rare occasions, serious side effects have raised concerns about the use of these
medicines in children younger than 6 years. The rare but serious potential side effects include
convulsions, increased heart rate, decreased level of consciousness, abnormal heart rhythms and
hallucinations.
83
Table 3: Medications Not to Be Used for Cough and Cold in Children <6 Years
Therapeutic Categories Active Ingredients
Antihistamines in cough and cold brompheniramine maleate
medicines
chlorpheniramine maleate
Therapeutic Categories Active Ingredients
clemastine hydrogen fumarate
dexbrompheniramine maleate
diphenhydramine hydrochloride
diphenylpyraline hydrochloride
doxylamine succinate
pheniramine maleate
phenyltoloxamine citrate
promethazine hydrochloride
pyrilamine maleate
triprolidine hydrochloride
Antitussives dextromethorphan
dextromethorphan hydrobromide
diphenhydramine hydrochloride
Expectorants guaifenesin
Decongestants ephedrine hydrochloride/sulfate
phenylephrine hydrochloride/sulfate
pseudoephedrine hydrochloride/sulfate
<
Therapeutic strategies for use in children include:
Prop the child upright to sleep in the daytime (e.g., in a car seat) to help prevent nasal
congestion.
Use saline drops and a nasal aspirator to suction mucus from the nasal passages. This is
especially important if children have difficulty feeding.
Use a humidifier to keep the oropharynx moist (avoid steam vaporizers, which can cause burns
if the child tips it over). It is important to clean the humidifier regularly to prevent mould growth.
Ensure the child drinks plenty of clear fluids (e.g., water, diluted nonsweetened fruit juice or clear
soups) to prevent dehydration and keep the throat moist.
Parents can consult Health Canada or the Canadian Paediatric Society websites for more
information.
See Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions.
Table 4 contains information on monitoring therapy.
Table 4: Monitoring of Therapy for the Common Cold, Influenza, Rhinosinusitis and Pharyngitis
Symptoms Monitoring Endpoint of Therapy Actions
Common cold Patient: Daily Patient able to Optimize
symptoms Healthcare perform daily nonpharmacologic
(congestion, practitioner: Next visit activities. measures.
rhinorrhea, cough, or by telephone 2–3 Patient able to sleep. Change treatment if
sore throat) days later not effective.
Insomnia Patient: Daily No insomnia. Change medication

(oral decongestant) Healthcare schedule (daytime use
practitioner: 1 wk only) or discontinue
medication.
High blood pressure Patient or healthcare No elevation in blood Stop decongestant if

(oral decongestant in practitioner: Monitor pressure above blood pressure
hypertensive patients blood pressure 2 baseline. elevated above
only) times in the first week baseline. Recommend
trial of topical
decongestant.

(antihistamine) Healthcare schedule (bedtime
practitioner: Next visit only) or discontinue
or by telephone when treatment.

(antitussive) Healthcare schedule (bedtime
practitioner: Next visit only) or treatment.
or by telephone when

Proper use of medication
Expected results and management of side effects
Lack of efficacy of antibiotics against viral infections and potential to contribute to antimicrobial
resistance with misuse/overuse
When to contact a healthcare provider.
Drug Tables
Drug Tables
Table 5: Decongestant Medications for Upper Respiratory Tract Infections

Interactions
Drug Class: Decongestants, oral
pseudoephedrine Adults and Mild CNS Beta-blockers: Caution in

children stimulation Antihypertensive patients with
Eltor 120, ≥12 y: 60 mg (nervousness, effects may be heart disease,
Sudafed Q4–6H po excitability, reduced. high blood
Decongestant SR: 120 mg restlessness, MAOI and ergot pressure,
12 hour, Q12H po dizziness, derivatives may hyperthyroidism,
generics. Maximum: weakness, enhance the diabetes, angle-
Combination 240 mg per insomnia). hypertensive closure
products: Advil day Peripheral effect of glaucoma or
Cold and Sinus Children 6– vasoconstriction. pseudoephedrine. prostatic
Plus, Benylin, 11 y: 30 mg Tachycardia or Concurrent use enlargement.
Robitussin, Q4–6H po palpitation may and use within 14 Onset of action
Sinutab Sinus Maximum: occur. Blood days of 30 min.
and Allergy, 120 mg per pressure may be discontinuation
Tylenol day increased in of MAOI is
Children's, hypertensive contraindicated.
For patients. May
others
combination adversely affect
$$ products, blood sugar
consult label control in
for additional diabetics.
ingredients.
Follow
directions on
label.
Interactions
phenylephrine Consult Decongestant: Decongestant: Caution in

Dimetapp, individual Mild CNS MAOI: Avoid patients with
generics product stimulation combination. Risk heart disease,
labels (nervousness, persists for 2 wk high blood
$$ Dose based following pressure,
excitability,
on restlessness, discontinuation hyperthyroidism,
phenylephrine dizziness, of nonselective diabetes, angle-
content: weakness, MAOI (e.g., closure
Adults: 10 mg insomnia). phenelzine). glaucoma or
Q4H; Peripheral Risk of severely prostatic
maximum vasoconstriction. elevated blood enlargement.
60 mg/24h Tachycardia or pressure when Onset of action
po palpitation may combined with 30 min.
occur. Blood ergot derivatives
Children 6– (e.g., Decongestants are
11 y: 5 mg pressure may be
increased in bromocriptine, similar to adrenaline,
Q4H; cabergoline,
maximum hypertensive
ergotamine). thus they can cause
patients. May
30 mg/24h
adversely affect Antagonizes blood vessels to
po
blood sugar effects of alpha1- constrict and increase
blockers (e.g.,
control in
alfuzosin,
blood pressure. Also, as
diabetics.
doxazosin, with adrenaline,
Antihistamine:
Drowsiness, prazosin, decongestants can
fatigue, silodosin, release sugar into the
anticholinergic tamsulosin,
terazosin). blood stream and raise
effects such as
dry eyes, dry Antihistamine: blood sugars
mouth and urinary Additive effects
retention. with other
Paradoxical anticholinergic
stimulatory effects drugs and CNS
may occur in depressants.
children and the
elderly.
Drug Class: Decongestants, topical
oxymetazoline Adults and Local burning and MAOI: Avoid Onset of action:
Claritin Allergy children stinging, sneezing, combination. Risk 5–10 min.
Decongestant, ≥12 y: 0.05% dryness of the persists for 2 wk Long duration of
Dristan Long solution: nasal mucosa. following action lasting up
Lasting Nasal 2–3 drops or Rhinitis discontinuation to 12 h.
Mist, Drixoral, sprays/nostril medicamentosa of nonselective Concurrent
generics Q12H when used for MAOI (e.g., therapy with
Maximum more than 3–5 phenelzine). MAOI may
$ duration: 3–5 days. cause
days Bradycardia, hypertensive
tachycardia, crisis.
hypertension and
hypotension have
been reported.
Interactions
phenylephrine Adults and Local burning and MAOI: Avoid Onset of action:
Dristan Nasal children stinging, sneezing, combination. Risk 5–10 min.
Mist, Soframycin ≥12 y: 0.25% dryness of the persists for 2 wk Short duration
Nasal Spray or 0.5% nasal mucosa. following of action lasting
solution: Rhinitis discontinuation up to 4 h.
$$ 2–3 drops or medicamentosa of nonselective Concurrent
sprays/nostril when used for MAOI (e.g., therapy with
Q4H more than 3–5 phenelzine). MAOI may
Maximum days. cause
duration: 3–5 Bradycardia, hypertensive
days tachycardia, crisis.
hypertension and
hypotension have
been reported.
xylometazoline Adults and Local burning and MAOI: Avoid Onset of action:
Balminil Nasal children stinging, sneezing, combination. Risk 5–10 min.
Decongestant, ≥12 y: 0.05% dryness of the persists for 2 wk Long duration of
Otrivin, generics or 0.1% nasal mucosa. following action lasting up
solution: Rhinitis discontinuation to 12 h.
$ 2–3 drops or medicamentosa of nonselective Concurrent
sprays/nostril when used for MAOI (e.g., therapy with
Q8–10H more than 3–5 phenelzine). MAOI may
Maximum days. cause
duration: 3–5 Bradycardia, hypertensive
days tachycardia, crisis.
hypertension and
hypotension have
been reported.
a Cost of 1 unit (spray pump, drops) or 100 mL of liquid or 12 tablets; includes drug cost only.

Legend: $ < $3 $$ $3–6
Table 6: Neuraminidase inhibitors

Drug Class: Antivirals, neuraminidase inhibitors

oseltamivir Treatment:24,85,86,87 Nausea, Avoid Take with food.

Adults: 75 mg BID vomiting. administration Safety in pregnancy not
Tamiflu po × 5 days 48 h prior to and established but currently
for 2 wk after recommended as first-
Children: influenza
$$ line agent in pregnant
≥1 y and ≤15 kg: 30 vaccine.
mg BID po × 5 days women.
>15–23 kg: 45 mg For dose adjustments,
BID po × 5 days consult the Compendium
>23–40 kg: 60 mg of Therapeutic Choices:
BID po × 5 days Influenza.
>40 kg: 75 mg BID
po × 5 days
Prophylaxis85,86,87:
Adults and children
≥13 y: 75 mg once
daily po
Children: ≥1 y and
≤15 kg: 30 mg once
daily po
>15–23 kg: 45 mg
once daily po
>23–40 kg: 60 mg
once daily po
>40 kg: 75 mg once
daily po
Duration of
prophylaxis is
variable; used for
the duration of the
outbreak
zanamivir Treatment for ≥7 y: Nausea, Avoid Safety in pregnancy not

Relenza 10 mg (2 vomiting. administration established.
inhalations) BID × 5 48 h prior to and
$$ days for 2 wk after
Prophylaxis for ≥7 y: influenza
10 mg (2 vaccine.
inhalations) daily ×
10 days
a Cost of a course of treatment; includes drug cost only.

Legend: $ < $25 $$ $25–50
Suggested Readings
Desrosiers M, Evans GA, Keith PK et al. Canadian clinical practice guidelines for acute and chronic
rhinosinusitis. Allergy Asthma Clin Immunol 2011;7:2.
Fashner J, Ericson K, Werner S. Treamtent of the common cold in children and adults. Am Fam Physician
2012;86:153-9.
74. Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database
Syst Rev 2013;1:CD000980.
75. Marshall S. Zinc gluconate and the common cold. Review of randomized controlled trials. Can Fam
Physician 1998;44:1037-42.
76. Mossad SB, Macknin ML, Medendorp SV et al. Zinc gluconate lozenges for treating the common
cold. A randomized, double-blind, placebo-controlled study. Ann Intern Med 1996;125:81-8.
77. Garland ML, Hagmeyer KO. The role of zinc lozenges in the treatment of the common cold. Ann
78. Macknin ML, Piedmonte M, Calendine C et al. Zinc gluconate lozenges for treating the common cold
in children: a randomized controlled trial. JAMA 1998;279:1962-7.
79. Turner RB, Cetnarowski WE. Effect of treatment with zinc gluconate or zinc acetate on experimental
and natural colds. Clin Infect Dis 2000;31:1202-8.
80. Caruso TJ, Prober CG, Gwaltney JM. Treatment of naturally acquired common colds with zinc: a
structured review. Clin Infect Dis 2007;45:569-74.
81. Jackson JL, Peterson C, Lesho E. A meta-analysis of zinc salts lozenges and the common cold. Arch
Intern Med 1997;157:2373-6.
82. Science M, Johnstone J, Roth DE et al. Zinc for the treatment of the common cold: a systematic
review and meta-analysis of randomized controlled trials. CMAJ 2012;184:E551-61.
83. Health Canada. Health Canada releases decision on the labelling of cough and cold products for
children. Available from: www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2008/13267a-
eng.php. Accessed December 4, 2014.
84. Smith MB, Feldman W. Over-the-counter cold medications. A critical review of clinical trials between
1950 and 1991. JAMA 1993;269:2258-63.
85. Stiver HG, Evans GA, Aoki FY et al. Guidance on the use of antiviral drugs for influenza in acute care
facilities in Canada, 2014-2015. Can J Infect Dis Med Microbiol 2015;26:e5-8.
86. Oo C, Barrett J, Hill G et al. Pharmacokinetics and dosage recommendations for an oseltamivir oral
suspension for the treatment of influenza in children. Paediatr Drugs 2001;3:229-36.
87. Oo C, Hill G, Dorr A et al. Pharmacokinetics of anti-influenza prodrug oseltamivir in children aged 1-5
years. Eur J Clin Pharmacol 2003;59:411-5.

Common Cold and Influenza
Common Cold and Influenza—What You Need to Know
The common cold and influenza (the flu) are viral infections. They usually go away in 7–10 days. Antibiotics for bacterial
infections will not help you get better from a cold or flu.
Hints to help you feel better if you have a cold or the flu:
Drink lots of fluids and get plenty of rest.

You can try a cool-mist humidifier. Be sure to clean it regularly to prevent bacteria or mould growth.
Soothe your irritated nose with a saline nose spray. Use saline drops in young children.
Medications for colds and the flu
Many medications for cold and flu symptoms are available without a prescription. Ask your pharmacist if medication can help
you or not.
Check with your doctor or pharmacist before giving cough or cold products to children. Cough, cold or flu
products should not be used in children less than 6 years old.
Use acetaminophen or ibuprofen if you have a fever, aches or pains. Do not give ASA (such as Aspirin) to a child
or teenager who has a cold or the flu.
Do not give medicine labelled for older children or adults to young children.
Do not use more than 1 cough and cold product at a time. Many products contain the same ingredients.
Measure the right dose with a measuring device. Do not use a regular spoon.
See a healthcare provider if any of these things happen:
You have trouble breathing

You make strange sounds when you breathe
Your throat is very sore
You have a lung disease such as asthma, emphysema or chronic bronchitis
You have a fever for more than 24 hours
Your cold or flu lasts for more than 7–10 days
Take a child to a healthcare provider if any of these things happen:
They seem to have an earache

They have a high fever (temperature above 39°C or 102°F)
They seem very sleepy most of the time
They seem very cranky or fussy most of the time
They have rapid breathing or trouble breathing
They have a cough that lasts more than 10 days
They have a skin rash
They seem to be dehydrated (dry mouth, no urine output over 6 hours, crying without tears)
How can you prevent colds and flu?
There is no sure way to prevent colds and flu. A yearly flu shot will help to cut your chance of getting the flu. You can also help
protect yourself by washing your hands often. Clean hands help to prevent colds and flu from spreading.
Always wash your hands:
Before cooking or eating

Before feeding a baby or child
Before giving someone medication
After wiping your nose
Follow these steps for proper hand-washing:
1. Wet your hands under running water.

2. Using soap, scrub your hands for 20 seconds (the time it takes to sing Twinkle Twinkle Little Star).
3. Rinse your hands under running water for 10 seconds.
4. Dry your hands with a clean towel.
Diabetes Care
Lori MacCallum, BScPhm, PharmD, CDE

Date of Revision: May 2017
CPhA acknowledges the contribution of Maryann Hopkins as a previous author of this chapter.
Introduction
It is estimated that more than 2 million Canadians have known diabetes plus an estimated 400 000 are
unaware they have diabetes, and these numbers are continuing to rise. By 2018–2019, the number
diagnosed with diabetes is expected to reach 3.7 million.1 Diabetes is the leading cause of adult-onset
blindness, kidney disease, and nontraumatic lower limb amputations. In addition, people with diabetes have
a much higher risk of cardiovascular disease, the leading cause of death in this population.2 People with
diabetes have higher mortality rates and decreased quality of life, primarily due to the complications of the
disease. There are tremendous fiscal implications. It is estimated that diabetes costs the Canadian
healthcare system $12.2 billion annually, mainly due to the costs of diabetic complications.3
Pathophysiology
Type 1 diabetes is primarily the result of the destruction of pancreatic β-cells. It includes those cases due to
an autoimmune process and those for which the etiology of β-cell destruction is unknown. It is thought to be
multifactorial (a genetic predisposition combined with environmental factors), but the exact cause remains
unknown. Type 1 diabetes can be diagnosed at any age but most commonly presents between 5 and 7
years of age or around puberty, and insulin replacement is needed for survival. Type 1 diabetes that
develops in adults may be difficult to distinguish from type 2 diabetes.4
β-cell failure and insulin resistance in muscle and liver are the primary defects in type 2 diabetes. Insulin
resistance in the liver leads to an overproduction of glucose in the fasting state and impaired suppression
following a meal. Insulin resistance in the muscle leads to impaired uptake of glucose following a meal,
leading to postprandial hyperglycemia. There are also abnormalities of the fat cell (increased lipolysis
leading to increased free fatty acids which impairs insulin secretion), gastrointestinal tract (deficiency or
resistance to the incretin gut hormones), α-cells of the pancreas (increased secretion of glucagon which
increases production of glucose by the liver), kidney (increased glucose reabsorption) and brain (insulin
resistance). All of these lead to the development of glucose intolerance, and have been described by
DeFronzo as the Ominous Octet.5 Heredity plays a major role in the development of insulin resistance. This
genetic predisposition to insulin resistance, combined with obesity and decreased physical activity, both
insulin resistant states, puts major stress on the β-cells to maintain normal glucose. Initially, β-cells
compensate for insulin resistance with increased insulin production. Eventually the β-cells fail, first leading
to a rise in postprandial glucose and then fasting plasma glucose, and eventually type 2 diabetes.5
Individuals with prediabetes have higher than normal blood glucose values but not high enough to meet the
diagnosis of diabetes. Prediabetes includes impaired fasting glucose, impaired glucose tolerance or an
HbA1c of 6–6.4%. Individuals with prediabetes are at risk of developing type 2 diabetes although not all will
progress. Once patients have impaired glucose tolerance, they already have insulin resistance and may have
lost up to 80% of their β-cell function.5 These patients should be carefully monitored and screened for the
development of diabetes as well as an assessment of cardiovascular risk factors as they are at higher risk
of cardiovascular disease, particularly those with impaired glucose tolerance.
7,8,9,10
Table 1: Examples of Drugs Known to Raise Blood Glucose
Alpha-interferon HMG CoA-reductase inhibitors
Antipsychotics, second-generation Nicotinic acid
Beta-adrenergic agonists Pentamidine
Beta-blockers Phenytoin
Calcineurin inhibitors Protease inhibitors
Diazoxide Thiazide diuretics
Gatifloxacin Thyroid hormone
Glucocorticoids
Diabetes in pregnancy includes pregestational diabetes (type 1 and type 2) or gestational diabetes.
Pregestational diabetes is diabetes that was present before pregnancy. Gestational diabetes refers to
diabetes diagnosed during pregnancy. Those with gestational diabetes are at high risk of developing type 2
diabetes in subsequent years and should be screened between 6 weeks and 6 months postpartum to detect
prediabetes and diabetes.6
For more information on gestational diabetes, consult the Compendium of Therapeutic Choices: Diabetes
Mellitus.
Diabetes may also be caused by other endocrine diseases (e.g., Cushing's disease, acromegaly), other
genetic defects, infections or toxins, or may be associated with drug therapy (Table 1). Patients with known
risk factors for diabetes (Table 2) should be screened.
11
Table 2: Known Risk Factors for Type 2 Diabetes
Member of a high-risk population e.g., Aboriginal, African, Asian, South Asian or Hispanic
descent
Acanthosis nigricans
Age ≥40 y
First-degree relative with type 2 diabetes
Giving birth to a macrosomic infant
History of prediabetes (impaired fasting glucose, impaired glucose tolerance or HbA1c 6–
6.4%)
History of gestational diabetes
Presence of vascular risk factors: abdominal obesity, HDL cholesterol <1 mmol/L in males or
<1.3 in females, hypertension, triglycerides ≥1.7 mmol/L, overweight
Presence of associated diseases: bipolar disorder, depression, HIV infection, obstructive sleep
apnea, polycystic ovary syndrome, schizophrenia
Presence of end-organ damage associated with diabetes:
microvascular: nephropathy, retinopathy, neuropathy
macrovascular: coronary, cerebrovascular or peripheral artery disease
Use of drugs associated with increased risk of diabetes e.g., glucocorticoids, protease
inhibitors, second-generation antipsychotics
Goals of Therapy
Adopt a healthy lifestyle
Prevent microvascular and macrovascular complications
Establish a regular follow-up schedule based on established recommendations
Avoid blood glucose values outside of established targets
Recognize, prevent and treat hypoglycemia
Patient Assessment
Though many people with type 2 diabetes are asymptomatic, signs and symptoms may be present (Table 3).
The diagnosis of diabetes is dependent upon laboratory testing following specific diagnostic criteria.
Table 3: Possible Signs and Symptoms of Diabetes
Blurred vision Frequent urination
Cuts and bruises that are slow to heal Tingling or numbness in hands or feet
Extreme fatigue Unusual thirst
Frequent or recurring infections Weight change (gain or loss)
Diagnostic Criteria for Diabetes
The diagnosis of diabetes requires blood glucose or HbA1c results obtained in the laboratory. Capillary
blood glucose readings suggesting the presence of diabetes should be confirmed with plasma glucose
(PG) levels:12
Fasting plasma glucose (FPG; no caloric intake for at least 8 hours) ≥7 mmol/L, or
An HbA1c ≥6.5% using a standardized, validated assay in the absence of factors that affect the
accuracy of the test (not for suspected type 1 diabetes, children, adolescents or pregnancy), or
A plasma glucose level 2 hours after a 75 g glucose load ≥11.1 mmol/L, or
Random plasma glucose ≥11.1 mmol/L
HbA1c may be misleading in people with hemoglobinopathy, iron deficiency, hemolytic anemia or severe
renal or hepatic disease.13 In addition, African Americans, Aboriginals, Hispanics and Asians have HbA1c
values that are 0.4% higher than those of Caucasians at similar levels of glycemia.14,15 HbA1c is also
affected by age, rising by up to 0.1% per decade of life. More studies are required in these populations to
determine whether age or ethnic-specific thresholds are required.16,17
In the absence of symptomatic hyperglycemia, if a single laboratory test result is in the diabetes range, a
confirmatory laboratory test (e.g., FPG, HbA1c) must be done on another day. It is preferable that the
same test be repeated for confirmation, but a random PG in the diabetes range in an asymptomatic
individual should be confirmed with an alternative test. In the case of symptomatic hyperglycemia, the
diagnosis has been made and a confirmatory test is not required before treatment is initiated. In
individuals in whom type 1 diabetes is likely (younger or lean or symptomatic hyperglycemia, especially
with ketonuria or ketonemia), confirmatory testing should not delay initiation of insulin, to avoid rapid
deterioration. If results of 2 different tests are available and both are above the diagnostic cutpoints, the
diagnosis of diabetes is confirmed. When the results of more than 1 test are available and the results are
discordant, the test whose result is above the diagnostic cutpoint should be repeated and the diagnosis
made on the basis of the repeat test.12
Optimal glycemic control is critical to both the management of diabetes and prevention of
complications. Both the Diabetes Control and Complications Trial (DCCT), a prospective randomized
control trial in type 1 diabetes, and the United Kingdom Prospective Diabetes Study (UKPDS), which was
conducted in patients with newly diagnosed type 2 diabetes, demonstrated a reduction in microvascular
complications with tighter glycemic control.18,19 In the UKPDS there was a 25% relative risk reduction in
microvascular complications.19 The DCCT showed a relative risk reduction of 76% in incident
retinopathy, a 54% reduction in progression of retinopathy, a 54% reduction in nephropathy and a 60%
reduction in clinical neuropathy.20,21 Ten-year observational follow up of the UKPDS participants
demonstrated that despite a loss of glycemic control, the reduction in microvascular complications
persisted, MI was reduced by 15% and death from any cause by 13% in the intensively treated group.22
Follow-up of the DCCT showed that intensive treatment reduced the risk of any cardiovascular event by
42% and the risk of nonfatal MI, stroke, or death from cardiovascular disease by 57%.23
Glycemic targets should be individualized based on age, duration of diabetes, risk of severe
hypoglycemia, presence of cardiovascular disease and life expectancy (Table 4).24 Both the fasting and
postprandial blood glucose contribute to the HbA1c value and correlate with the risk of complications.
For most individuals with diabetes, the target should be an HbA1c ≤7% to reduce the risk of
microvascular complications and if implemented early in the course of the disease, may also reduce the
risk of macrovascular complications. To achieve target HbA1c levels, individuals should aim for a
preprandial or fasting plasma glucose of 4–7 mmol/L and a 2-hour postprandial glucose of 5–10
mmol/L. If an HbA1c ≤7% cannot be achieved with a postprandial glucose target of 5–10 mmol/L, lower
the target to 5–8 mmol/L.24
24
Table 4: Targets for Adults with Type 1 or Type 2 Diabetes
Target Value Patient Group
HbA1c ≤6.5% Some patients with type 2 diabetes, to further lower risk of
nephropathy and retinopathy balanced against the increased risk
of hypoglycemia
HbA1c ≤7% Most patients with type 1 or type 2 diabetes
HbA1c 7.1–8.5% Patients with: limited life expectancy, high-level functional

dependency, extensive coronary artery disease at high risk of
ischemic events, multiple comorbidities, recurrent severe
hypoglycemia, hypoglycemia unawareness, long-standing diabetes
where lower HbA1c cannot be achieved despite effective doses of
multiple medications
Age alone is not an indicator for more or less stringent targets. In the frail elderly, prevention of
hypoglycemia is the priority as the risk of hypoglycemia increases markedly with age. While avoiding
symptomatic hyperglycemia, glycemic targets are an HbA1c ≤8.5% and fasting or preprandial glucose of
5–12 mmol/L.25
Intensive lifestyle interventions in people with type 2 diabetes can produce improvements in weight
management, fitness, glycemic control and cardiovascular risk factors. The Look AHEAD trial was a large
(n=5145) randomized control trial that examined whether intensive lifestyle intervention for weight loss
would decrease cardiovascular morbidity and mortality in overweight or obese individuals with type 2
diabetes. Although the intervention arm did achieve greater weight loss, greater reduction in HbA1c and
greater initial improvements in fitness and cardiovascular risk factors (with the exception of LDL), there was
no difference between the lifestyle intervention and the control arm in the primary composite endpoint of
cardiovascular morbidity and mortality after a median follow up of 9.6 years.26 However, because of the
many other benefits of adopting a healthy lifestyle including weight loss, lifestyle intervention remains the
mainstay of diabetes care.
The recommendation for people with diabetes is a minimum of 150 minutes per week of moderate- to
vigorous-intensity exercise. This should be spread over at least 3 days of the week with no more than 2
consecutive days without exercise. This should be combined with at least 2 sessions per week (3 sessions
preferable) of resistance exercise (i.e., exercise bands or weights).27 Patients are encouraged to follow
Canada’s Food Guide to Healthy Eating. A nutritionally balanced, calorie-reduced diet is further
recommended in overweight or obese patients to achieve a 5–10% weight loss.28 Finally, it is important to
determine the smoking status of all patients and to encourage patients who currently smoke to begin the
process of quitting by providing resources, support and medication if indicated.
Antihyperglycemic medications target different pathophysiologic abnormalities associated with type 2
diabetes, including insulin resistance, decreased insulin secretion, excessive glucose output by the liver and
increased glucose reabsorption by the kidneys. To achieve recommended glycemic targets, combinations of
different agents may be used.
The sulfonylureas and meglitinides are insulin secretagogues, and stimulate endogenous insulin release
from the β-cells of the pancreas. Metformin acts primarily by improving insulin action in the liver (reduces
glucose production) and enhances insulin activity in muscle and fat cells. The thiazolidinediones
(pioglitazone, rosiglitazone) decrease insulin resistance in peripheral tissues and the liver. Acarbose is an
alpha-glucosidase inhibitor that slows the breakdown of certain sugars and starches in the gut, thus slowing
glucose absorption. Dipeptidyl peptidase-4 inhibitors (alogliptin, linagliptin, saxagliptin, sitagliptin) prevent
the breakdown of the gut hormones, GLP-1 and GIP, thereby increasing the release of insulin from β-cells
and suppressing the release of glucagon from α-cells. Glucagon-like peptide agonists (dulaglutide,
exenatide, liraglutide) also increase insulin release and suppress glucagon. Sodium glucose co-transporter
2 (SGLT2) inhibitors (canaglifozin, dapaglifozin, empagliflozin) act on the kidney and lower glucose by
increasing urinary glucose excretion.
For more information on pharmacologic therapy for diabetes, consult the Compendium of Therapeutic
Choices: Diabetes Mellitus.
Insulin
Ailments—Diabetes Products: Insulin Products.
To achieve normal blood glucose levels, those with type 1 diabetes require exogenous insulin. Those
with type 2 diabetes may also require insulin therapy in certain circumstances: at diagnosis in those with
symptomatic hyperglycemia and metabolic decompensation, if blood glucose targets are not being
reached with lifestyle changes or other antihyperglycemics, temporarily during illness, pregnancy or
stress, or for a medical procedure or surgery.
The insulin dose, type of insulin required and the time of day the insulin needs to be administered
depend on individual circumstances. Table 5 describes some common insulin regimens used in the
management of diabetes.
Various insulin products are available in Canada; their characteristics are listed in Table 6.
Insulin Storage
Unopened insulin vials and cartridges should be stored in the refrigerator (2–8°C). Once in use,
insulin may be stored at room temperature. Insulin stored at room temperature causes less irritation
and burning when administered. Insulin should not be frozen or exposed to extreme heat (>30°C) for
prolonged periods as this will affect its action. Caps should be kept on insulin pens to protect insulin
from light, and insulin should not be stored in direct sunlight. Once insulin is opened, it may be used
for up to 28 days when stored at room temperature, with the exception of insulin detemir, which may
be used for up to 42 days.31
Insulin Absorption
Insulin is absorbed most rapidly and consistently from the abdomen. Moderate absorption rates
occur at the upper arm and the lateral side of the thigh. The slowest rate of absorption occurs from
the buttock. Massaging the injection site immediately before or after the injection increases the
absorption rate. Increased temperature of the injection site (e.g., from a hot bath, sauna, or exercise)
may increase the absorption rate. 31
Lipohypertrophy can develop from repeated use of the same injection site. Lesions vary in size and
may be detected visually or by palpation. Injecting into a lipohypertrophic site can result in a
decrease and variable rate of insulin absorption. Instruct patients not to inject into a lipohypertrophic
area. Injection sites should be inspected by a healthcare practitioner routinely to monitor for the
development of lipohypertrophy. To prevent lipohypertrophy and to ensure consistent absorption of
insulin, injection sites should be rotated within an anatomical area and a new needle should be used
for each injection. When changing from a lipohypertropic injection site to a healthy site, patients may
need to reduce their insulin dose. Blood glucose should be monitored more frequently.31
29,30
Table 5: Common Insulin Regimens
Regimen Advantages Disadvantages
Basal insulin once Convenient Lack of mealtime control

daily Causes less weight gain
One injection daily and hypoglycemia
(usually at bedtime). Easy method for starting
Analogues may be patients on insulin
given at bedtime or in
the morning. Can
continue oral agents
Premixed insulin Convenient—only 2 Less flexibility in dosing

twice daily injections per day as insulin is premixed
One injection of (must adhere to schedule)
premixed insulin Lack of flexibility in
before breakfast and activity levels, meal sizes
one injection before and times
supper. Continue Requires a bedtime snack
metformin. Insulin to avoid nocturnal
secretagogues are hypoglycemia
often stopped to avoid
Requires a consistent and
hypoglycemia
predictable lifestyle with
regard to meals and
activity
Basal plus bolus Flexibility for mealtimes Requires frequent blood

Bolus insulin with Useful for those with shift glucose monitoring
each meal and basal work or unpredictable More complex
insulin at bedtime. lifestyle Inconvenience of multiple
Continue metformin. injections
Insulin secretagogues
are stopped to avoid
hypoglycemia
Insulin pumps Better glycemic control Extensive training

Less severe hypoglycemia Rapid blood glucose
Greater flexibility deterioration if insulin
delivery fails (remind
patients to have insulin
for manual injection as
backup)
31
Best Practice Recommendations for Insulin Administration
Provide proper education and ensure regular assessment of injection sites and techniques.
Rotation of injection sites within all zones of an anatomical area is essential to avoid
lipohypertrophy.
Healthcare practitioners should know how to inspect and palpate injection sites and prevent
lipohypertrophy.
Shorter pen needles (4 mm, 5 mm and 6 mm) are suitable for all people with diabetes,
regardless of BMI; 6 mm needles are recommended for syringe use.
The abdomen is the preferred injection area for consistency of absorption.
Splitting of large insulin doses to reduce the volume of injection should be based on individual
need.
Glycemic variability and poor glycemic control may be related to injection techniques.
For cloudy insulin (e.g., NPH), the vial or cartridge should be rolled gently 10 times and then
tipped (not shaken) 10 times. The vial or cartridge should be inspected visually to ensure the
suspension has a consistent milky white appearance.
The lateral sides of the abdomen are the preferred injection sites for pregnant women.
29,30
Table 6: Characteristics of Insulin and Analogues
Class Type Onset (h)a Peak (h)a Duration (h)a
Rapid-acting aspart 10–15 min 1–1.5 3–5

insulin analogues glulisine 10–15 min 1–1.5 3–5
lispro 10–15 min 1–2 3.5–4.75
Short-acting human insulin 0.5 2–3 6.5

insulin regular, Toronto
pork insulin 0.5 2–4 5–7
Intermediate- human NPH 1–3 5–8 up to 18

acting insulin
pork NPH 1–3 6–12 24–28
Long-acting insulin glargine 1.5 No peak up to 24

analogues glargine U300 6 No peak 30
detemir 1.5 No peak 16–24
a
Onset, peak and duration may vary depending on product and patient characteristics.
A Canadian study found that 78% of people with diabetes reported taking a natural health product.32 It is
important for healthcare practitioners to ask patients about their use of natural health products, assess
for drug interactions and adverse events, and provide information on risks and benefits. Although some
natural health products have been shown to lower HbA1c in people with type 2 diabetes, the 2013
Diabetes Canada Clinical Practice Guidelines do not recommend their use at this time and further
research is needed.33
Microvascular Complications (Retinopathy, Nephropathy, Neuropathy)
Retinopathy
Diabetic retinopathy is the most common cause of new-onset blindness in the working age population.
Data showed a prevalence rate of 23% in people with type 1 diabetes, 14% in people with type 2 diabetes
on insulin therapy, and 3% in people receiving oral antihyperglycemic therapies.34 Risk factors for the
development or progression of diabetic retinopathy are longer duration of diabetes, elevated HbA1c,
increased blood pressure, dyslipidemia, low hemoglobin, pregnancy (in type 1 diabetes), proteinuria and
severe retinopathy itself.35,36 Because laser therapy can reduce the risk of blindness, it is imperative that
patients with diabetes be screened regularly for diabetic retinopathy to allow early diagnosis and
treatment. Landmark trials demonstrated that glycemic control (HbA1c ≤7%) reduced the development
and progression of retinopathy in patients with type 1 (DCCT18) and type 2 diabetes (UKPDS19). Blood
pressure control is also an important risk factor and the UKPDS trial demonstrated that tighter blood
pressure control reduced the progression of retinopathy.37 The target blood pressure for people with
diabetes is less than 130/80 mm Hg.38,39
34
Recommendations
Screen/evaluate for retinopathy annually beginning 5 years after the onset of diabetes in all
patients with type 1 diabetes (at or after age 15).
Screen for retinopathy in all patients at the time of diagnosis of type 2 diabetes. Follow up every
1–2 years unless severity dictates more frequent evaluation that is tailored to the severity of the
retinopathy.
Evaluate women with diabetes prior to pregnancy (when possible), in the first trimester,
throughout the pregnancy as needed and within the first year postpartum.
To prevent the onset and delay the progression of diabetic retinopathy, people with diabetes
should be treated to achieve optimal control of blood glucose and blood pressure. Fenofibrate,
in addition to statin therapy, may be used in patients with type 2 diabetes to slow the
progression of retinopathy.40
Changes in vision should be reported to a physician or optometrist.
Note: Individuals who start intensive diabetes management or pump therapy should have their
eyes checked pre- and post-intervention as there is a risk of worsening retinopathy (short-term)
due to intensification of diabetes therapy.
Nephropathy
Diabetes is the leading cause of kidney disease in Canada and kidney disease can decrease both life
expectancy and quality of life.41,42 People with diabetes can develop various forms of kidney disease
including diabetic nephropathy, ischemic damage and other renal diseases; up to half of patients with
diabetes will demonstrate signs of kidney damage over their lifetime.43,44,45 Diabetic nephropathy
involves the development or worsening of proteinuria. Patients with diabetes should be screened for
chronic kidney disease (CKD) by screening for albuminuria with a random urinary albumin-to- creatinine
ratio (ACR) and by assessing renal function with eGFR. Because all patients with CKD are considered at
high risk for cardiovascular disease, cardiovascular risk factors should also be assessed and optimized.
Optimal glycemic and blood pressure control have been shown to reduce the risk of development and
progression of diabetic nephropathy.19,46 The use of renin-angiotensin-aldosterone system (RAAS)
blockers (ACE inhibitors and ARBs) has been shown to reduce the risk of development47,48 and
progression49,50 of diabetic nephropathy, independent of blood pressure lowering in those with diabetes
and hypertension.
51
Recommendations
Screen with a random ACR and a serum creatinine converted to an eGFR in postpubertal
individuals with type 1 diabetes annually, beginning 5 years after diagnosis. Those with type 2
diabetes should be similarly screened at diagnosis and then annually. Recent fever, major
exercise, urinary tract infection, menstruation, decompensated heart failure or acute severe
elevation of blood pressure or blood glucose can elevate the ACR. Screening for albuminuria
should be delayed until these conditions are resolved.
Maintain optimal blood glucose to prevent or delay the progression of diabetic nephropathy.
Maintain optimal blood pressure control to prevent or delay the progression of diabetic
nephropathy.
The use of an ACE inhibitor or ARB can delay the progression of diabetic nephropathy.
Advise women of child-bearing potential about the importance of avoiding pregnancy if taking
an ACE inhibitor or an ARB because of the risk of congenital malformations.
Reduce or eliminate all modifiable risk factors for heart disease, e.g., smoking, excessive
alcohol intake, obesity, high cholesterol and blood pressure, physical inactivity.
All patients with diabetes, but especially those with CKD, should be aware of the “sick day”
medication list (Table 7). They should be instructed to hold these medications if they become ill
and are unable to maintain adequate fluid intake due to vomiting and/or diarrhea, because their
kidney function may worsen. Patients should be instructed to monitor blood glucose more
frequently and adjust their doses of insulin or other antihyperglycemic agents as necessary.
Regularly assess medications in patients with CKD to determine whether their renal function
warrants dosage adjustment or discontinuation of renally eliminated medications.
52
Table 7: Sick-day Medication List
Letter Drug/Class Reason for Caution with Inadequate Fluid Intake
S Sulfonylureas Renal clearance may be reduced, leading to increased

risk of adverse effects
A ACE inhibitors May impair renal function
D Diuretics, direct renin May impair renal function

inhibitors
M Metformin Renal clearance may be reduced leading to increased

risk of adverse effects
A Angiotensin receptor May impair renal function

blockers
N Nonsteroidal anti- May impair renal function

inflammatory drugs
S SGLT2 inhibitors May impair renal function
Neuropathy
Detectable sensorimotor polyneuropathy will develop within 10 years of the onset of diabetes in 40–50%
of individuals.53 Diabetic neuropathy can lead to foot ulceration and eventual amputation, and continues
to be the leading cause of lower extremity amputation. Optimal glycemic control has been shown to
prevent or reduce the progression of diabetic neuropathy and is the only disease-modifying treatment
available. Patients often experience neuropathic pain and anticonvulsants and antidepressants are
recommended for symptomatic relief. However, they do not affect the progression of the complication.
Opioids are also used for symptomatic relief but are considered a less favorable option because of risks
such as dependence, tolerance and diversion.54
54
Recommendations
Screen for peripheral neuropathy by assessing loss of sensitivity to the 10-g monofilament or to
vibration at the dorsum of the great toe, when type 2 diabetes is diagnosed and annually
thereafter. In those with type 1 diabetes, screening should begin 5 years after diagnosis in
postpubertal individuals and annually thereafter.
Optimal glycemic control is recommended for reducing onset and progression of neuropathy.
Antidepressants (amitriptyline, duloxetine and venlafaxine) and anticonvulsants (gabapentin,
pregabalin and valproate) may be used alone or in combination for symptomatic relief of
peripheral neuropathic pain.
Counsel all patients on the importance of foot care, to reduce the risk of ulceration and
amputation resulting from reduced foot sensitivity.
Cardiovascular Health and Hypertension in Patients with Diabetes

People with diabetes are at increased risk of cardiovascular disease, presenting as coronary heart disease,
stroke and peripheral vascular disease. People with diabetes have a cardiovascular age 10–15 years higher
than their chronological age.55 All patients with diabetes, regardless of age, require education on
implementing a healthy lifestyle (maintaining a healthy body weight, physical activity and smoking
cessation) as a way to reduce cardiovascular risk. The need for pharmacologic therapy for vascular
protection, including statins, ACE inhibitors/ARBs and acetylsalicylic acid, depends on the individual risk of
the patient.
Recommendations
To promote optimal cardiovascular health, the treatment of all patients with diabetes should include:56
Optimal blood glucose control

Blood pressure less than 130/80 mm Hg
Optimal lipid control
Healthy body weight
Regular physical activity
Smoking cessation
Healthy diet
The use of pharmacologic therapy for vascular protection is based on the patient’s cardiovascular risk.
The Diabetes Canada 2013 Clinical Practice Guidelines have established the following criteria:56
Statin therapy is recommended if:

Age ≥40 years, or irrespective of age in the following situations:
macrovascular disease
microvascular disease
diabetes present for >15 years and age >30 years
presence of other risk factors (male, smoker, family history of premature CVD, ECG
abnormalities, ACR >2 mg/mmol)
ACE inhibitor or ARB is recommended if:
Age ≥55 years, or irrespective of age in the following situations:
macrovascular disease
microvascular disease
Low-dose ASA (81–325 mg) once daily may be used for secondary prevention in those who already have
established CVD. Clopidogrel 75 mg once daily may be used in those unable to tolerate ASA. ASA should
not be routinely used for primary prevention in people with diabetes. In people with diabetes, ASA has
shown little or no benefit in the reduction of CAD events and stroke in primary prevention and there is an
increased risk of GI hemorrhage.56
Pneumonia and Influenza Vaccinations

Patients with diabetes are at high risk of morbidity and mortality from influenza and pneumococcal disease.
They should receive the influenza vaccine yearly. They should also receive a one-time pneumococcal
vaccine. For those >65 years, revaccination is recommended if the first vaccination was given >5 years ago
and before the age of 65.57
Alcohol Consumption
Alcohol may be incorporated into a diabetes meal plan, provided there are no other contraindications.
Alcohol consumption may mask symptoms of hypoglycemia, reduce hepatic glucose production and
increase ketones. However, when used in moderation it can be safe and even beneficial from a
cardiovascular perspective. Alcohol consumption should be limited to ≤2 standard drinks per day and <10
drinks per week in nonpregnant, nonlactating females with diabetes and ≤3 standard drinks per day and <15
drinks per week in men. One standard drink is defined as 10 g of alcohol which will be contained in 341 mL
of 5% alcohol beer, 43 mL of 40% alcohol spirits or 142 mL of 12 % alcohol wine.28
Increased physical activity and reduced or no food intake can increase the risk of hypoglycemia with
alcohol ingestion. In those with type 1 diabetes, moderate consumption of alcohol with or a few hours
after the evening meal can result in hypoglycemia the following morning or up to 24 hours later.28
Those using insulin or insulin secretagogues (e.g., meglitanides, sulfonylureas) should be informed of
the risk of delayed hypoglycemia resulting from alcohol consumption with or after the previous evening
meal and advised of measures to prevent hypoglycemia including: consuming alcohol with food, eating
a carbohydrate-containing snack before bed, adjusting insulin and monitoring blood glucose.
Inform patients who use metformin that consuming alcohol within the suggested limits is unlikely to
be problematic, but that acute or chronic ingestion of larger quantities of alcohol can contribute to the
development of lactic acidosis.
Alcohol contains 29 kJ or 7 cal/g, and can therefore contribute to weight gain. Alcohol-containing
medications are unlikely to contribute to poor blood glucose management or weight gain when used in
moderation.
Safe Use of Nonprescription Medications

It is important for individuals with diabetes to seek medical attention for more severe health problems
before they become problematic. However, many minor conditions may be safely treated with the same
nonprescription choices used by the general public.
Instruct patients with diabetes to use low-sugar/sugar-free products, as many liquid pharmaceuticals may
contain significant amounts of sugar. Also, the frequency of glucose monitoring needs to be increased
during illness to avoid loss of glucose control. Patients should have a sick-day management plan.
Occasional use of nonprescription analgesics has little or no effect on blood sugar. However, NSAIDs can
adversely affect blood pressure. Regular use of NSAIDs can also exacerbate renal impairment. Therefore,
refer patients with diabetes who require regular analgesia to their healthcare practitioner. Topical capsaicin
may be used for painful symptoms of diabetic neuropathy, but short-term burning and itching may limit its
use. Patients with peripheral neuropathic pain should be encouraged to optimize their blood glucose levels
in order to prevent progression of neuropathy.
Oral decongestants should be avoided in those with diabetes and hypertension. Another reason for cautious
use in patients with diabetes is the vasoconstriction caused by these agents, which can be more significant
in those with vascular complications such as poor circulation. Topical decongestants are less likely to raise
blood pressure than oral decongestants but should be avoided or used with caution in patients with
diabetes.
Patients experiencing heartburn, indigestion or reflux can be treated with nonprescription H2-receptor
antagonists or with low-sugar/sugar-free antacids. However, diabetes management may be complicated if
significant gastroparesis is present. Encourage patients to discuss use of these nonprescription
medications with the healthcare practitioner treating their diabetes.
Constipation or diarrhea can be treated with the usual nonprescription remedies (see Constipation and
Diarrhea). However, repeated constipation or diarrhea may signal gastroparesis that requires further
assessment.
Patients may travel to other countries where medication accessibility is different from Canada. Advise
patients to seek advice from a healthcare practitioner if they are choosing foreign nonprescription products.
Dental Care
Periodontitis is a chronic inflammatory disease characterized by destruction of the supporting structures of
the teeth. Epidemiological studies have shown that people with diabetes have a threefold higher prevalence
of periodontitis than those without diabetes.58 There is some evidence of improvement in glycemic control
after treating periodontal disease but additional large, well-conducted studies are required.59 People with
diabetes should be educated on the importance of good oral and periodontal health through regular dental
visits, brushing and flossing (see Oral Hygiene, Dental Plaque and Caries). Smoking is a major risk factor
and assistance with smoking cessation is recommended.
Skin Care
Hyperglycemia, poor circulation due to vascular abnormalities and peripheral neuropathy contribute to
impaired host defenses against infection. Nerve damage from diabetic neuropathy may also decrease
sweating, especially in the hands and feet, which normally helps to keep the skin moist. Patients with
diabetes are at increased risk of skin infections and delayed healing. Careful skin care is important, to
prevent serious skin problems. See Dry Skin and Minor Cuts and Wounds for discussion of these topics.
Foot Care
Foot problems are a major cause of morbidity and mortality, and individuals with diabetes are more prone to
developing serious foot problems than the general population. People with diabetes, peripheral neuropathy
and peripheral arterial disease are predisposed to foot ulceration and infection, and this can lead to lower
extremity amputation. Other risk factors include previous ulceration or amputation, structural deformity,
limited joint mobility, microvascular complications, high HbA1c and onychomycosis.60,61,62 Prevention of
ulceration and infection is critical and patients need to be educated on the importance of daily foot
examinations.63 Foot ulcers require early treatment using an interprofessional approach that addresses
glycemic control, infection, offloading of high-pressure areas, assessment of lower extremity vascular status
and wound care (see Foot Care for People with Diabetes—What You Need to Know).
For discussion of the management of foot infections, see Diabetic Foot Infections.
Managing Hypoglycemia
Hypoglycemia is defined as the development of autonomic or neuroglycopenic symptoms that respond to
the administration of carbohydrate (see Table 8), and a plasma glucose <4 mmol/L . Drug-induced
hypoglycemia is a complication of diabetes management and may limit the ability to achieve glycemic
targets. It is important that individuals receiving insulin or insulin secretagogues (sulfonylureas and
meglitinides) understand how to prevent, recognize and treat hypoglycemia. Severe hypoglycemia can lead
to confusion, seizure, coma and death.
Table 8: Symptoms of Hypoglycemia

Neurogenic (autonomic) Neuroglycopenic
Trembling Difficulty concentrating
Palpitations Confusion
Sweating Weakness
Anxiety Drowsiness/dizziness
Hunger Vision changes
Nausea Headache
To prevent hypoglycemia:
Review medication/insulin timing in relation to meals

Ensure each meal contains a source of carbohydrates
Snacks may be required before exercise
Review appropriate blood glucose monitoring including technique, frequency and interpretation of
results
Have the patient consume foods containing carbohydrates, if alcohol is consumed.
Some medications that may contribute to hypoglycemia are listed in Table 9.
9,64
Table 9: Examples of Drugs Known to Contribute to Hypoglycemia
Alcohol Pentamidine
Beta-blockers Quinine/Quinidine
Gatifloxacin Tramadol
Patients taking an alpha-glucosidase inhibitor (acarbose) must use glucose/dextrose tablets (or if
unavailable, milk or honey) to treat hypoglycemia.65
See also Low Blood Sugar (Hypoglycemia)—What You Need to Know.
Prevention of Diabetes
Type 1 Diabetes
Therapies to prevent the onset of type 1 diabetes are considered experimental and range from primary
prevention studies (in individuals with a genetic risk for type 1 diabetes but without pancreatic islet
autoantibodies) to secondary prevention (in individuals with multiple pancreatic islet autoantibodies but
without overt hyperglycemia).4
Type 2 Diabetes
Lifestyle intervention in individuals with prediabetes has been shown to reduce the progression to type 2
diabetes by as much as 58% through comprehensive programs that support dietary modification and
moderate physical activity (brisk walking) that results in a 5% weight loss.66,67,68 Long-term follow up of
individuals enrolled in these studies demonstrated sustained benefit up to 10–20 years.69,70
Pharmacologic therapy, including metformin, acarbose and thiazolidinediones, has also been shown to
reduce the progression from prediabetes to type 2 diabetes.66,71,72 However, in the Diabetes Prevention
Trial, the benefit of lifestyle intervention in preventing progression to diabetes was greater than with
metformin.66 The Diabetes Canada 2013 Clinical Practice Guidelines recommend that a structured
program of lifestyle intervention that includes moderate weight loss and regular physical activity be
implemented in those with impaired glucose tolerance or impaired fasting glucose to decrease the risk
of progression to type 2 diabetes. Those with prediabetes, particularly impaired glucose tolerance, are
also considered at higher risk of cardiovascular disease and therefore should be assessed for
cardiovascular risk factors as well.73
Resource Tips
Patients can find useful information from Diabetes Canada. Available from: www.diabetes.ca.
Suggested Readings
American Diabetes Association. Available from: www.diabetes.org.
American Diabetes Association. Standards of medical care in diabetes—2015. Diabetes Care 2015;38:S1-93.
Beaser RS, ed. Joslin's diabetes deskbook: a guide for primary care providers. 3rd ed. Philadelphia: Wolters
Kluwer Health/Lippincott Williams & Wilkins; 2014.
Diabetes Canada. Current guidelines for management of diabetes. Available from: www.diabetes.ca.
MacCallum L. Guidebook for pharmacists on diabetes management: helping patients reach treatment goals.
1st ed. Toronto: Banting & Best Diabetes Centre, University of Toronto; 2014.
References
1. Public Health Agency of Canada. Diabetes in Canada: Facts and figures from a public health
perspective. 2011. Available from: www.phac-aspc.gc.ca. Accessed August 28, 2015.
2. Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA
1979;241:2035-8.
3. Canadian Diabetes Association. An economic tsunami: the cost of diabetes in Canada . 2009.
Available from: www.diabetes.ca. Accessed August 28, 2015.
4. Atkinson M, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet 2014;383:69-82.
5. DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the
treatment of type 2 diabetes mellitus. Diabetes 2009;58:773-95.
6. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee, Thompson D, Berger
H et al. Diabetes and pregnancy. Can J Diabetes 2013;37:S168-83.
7. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Appendix 1. Etiologic
classification of diabetes mellitus. Can J Diabetes 2013;37:S197.
8. Park-Wyllie LY, Juurlink DN, Kopp A et al. Outpatient gatifloxacin therapy and dysglycemia in older
adults. N Engl J Med 2006;354:1352-61.
9. Luna B, Feringlos MN. Drug-induced hyperglycemia. JAMA 2001;286:1945-8.
10. Abdur R, Setter SM, Vue MH. Drug-induced glucose alterations part 2: drug-induced hyperglycemia
Diabetes Spectr 2011;24:234-8.
11. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee, Ekoé JM, Punthakee
Z et al. Screening for type 1 and 2 diabetes. Can J Diabetes 2013;37:S12-5.
12. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee, Goldenberg R,
Punthakee Z. Definition, classification, and diagnosis of diabetes, prediabetes and metabolic
syndrome. Can J Diabetes 2013;37:S8-11.
13. Gallagher EJ, Le Roith D, Bloomgarden Z. Review of hemoglobin A(1c) in the management of
diabetes. J Diabetes 2009;1:9-17.
14. Herman WH, MA Y, Uwaifo G et al. Differences in A1C by race and ethnicity among patients with
impaired glucose tolerance in the Diabetes Prevention Program. Diabetes Care 2007;30:2453-7.
Diabetes Care Devices
Ronald Silver, BSc, BScPharm

Diabetes Management
Technology has empowered patients with diabetes by giving them the tools to be more responsible for their
health management on a daily basis. The primary goals of therapy are to maintain health and avoid acute
and long-term complications. Diabetes care depends upon the daily commitment of those with diabetes to
self-management practices, with support from their healthcare practitioners. Effective diabetes self-
management improves HbA1c values and restores blood glucose (BG) levels to near-normal range.1 This
reduces the frequency of microvascular complications in patients with type 1 or type 2 diabetes, as well as
macrovascular risk in individuals with type 1 diabetes and some with type 2 diabetes.1,2,3,4
Blood Glucose Levels
Optimal BG levels are associated with a low risk of complications (Table 1). However, in some cases
these levels may be impossible to attain because of severe side effects (e.g., hypoglycemia),3
diminished quality of life, or cost.
4
Table 1: Recommended Targets for Glycemic Control
HbA1c (%) FPG or Preprandial PG 2-hour Postprandial PG
(mmol/L) (mmol/L)
Type 1 and type ≤7a 4–7 5–10

2 diabetes (5–8 if HbA1c targets not
being met)
a Higher or lower target values may be appropriate in specific individuals as discussed in the text.
Abbreviations: FPG = fasting plasma glucose; HbA1c = glycated hemoglobin; PG = plasma glucose
Fasting BG >5.6 mmol/L is associated with an increased risk of cardiovascular disease; however,
postprandial hyperglycemia appears to be a better predictor, with values >7.8 mmol/L associated with an
increase in all-cause mortality, and values >10 mmol/L with both microvascular complications and risk
of MI.4 Blood glucose levels correlate well with HbA1c levels. When HbA1c values are high, the major
influence is the fasting BG. When HbA1c levels approach 7%, postprandial plasma glucose becomes
more significant.4
Glycemic targets should be individualized based on the age, duration of diabetes, risk of severe
hypoglycemia, presence or absence of cardiovascular disease, and life expectancy.4 More intensive
control with an HbA1c <6.5% may be beneficial if it can be achieved without a significant increase in
hypoglycemia, and may be appropriate in patients with a shorter duration of diabetes, no evidence of
significant cardiovascular disease, and a longer life expectancy.4 An HbA1c target of <8.5% may be
considered in patients with a limited life expectancy, a higher level of functional dependency, a history of
severe hypoglycemia, or advanced comorbidities.4
Blood Glucose Monitoring

For comparative features of nonprescription products, consult the Compendium of Products for Minor
Ailments—Diabetes Products: Blood Glucose Meters.
Blood glucose monitoring can help inform adjustments in diabetes medications, particularly with insulin
treatment. If used appropriately it may help empower patients with diabetes to engage in self-care
behaviours such as diet selection, exercise and foot care.5
All available blood glucose meters test a capillary blood sample, which is whole blood. Meanwhile,
laboratories use venous plasma glucose as the benchmark (plasma is whole blood without the red blood
cells). Blood glucose meters are adjusted to give results which correlate with lab test results. At BG levels
>4.2 mmol/L, a difference of <20% is considered acceptable.6 Experts recommend comparing laboratory
and meter results at least annually, or when meter results do not appear to match HbA1c or other indicators.
Frequency of Testing
Healthcare practitioners care can assist patients in determining the frequency and timing of their blood
glucose measurements since the quality of evidence to support testing is variable.7 Factors to consider
are the potential benefits of monitoring vs. cost and pain associated with the procedure.8
Patients with type 1 diabetes should test at least 3 times daily; this has been associated with a 1%
reduction of HbA1c levels.6 Testing can be done on a twice-daily basis: before breakfast and after supper
one day, and after lunch and at bedtime the next day. Patients with type 2 diabetes using insulin more
than once a day should also test 3 times daily.6 Patients using multiple insulin injections or insulin pump
therapy should be testing 3 times daily or more.9
Patients with type 2 diabetes on oral medication should test periodically, testing once or twice weekly to
ensure that glycemic targets are being met between HbA1c tests. Tests should reflect pre-meal, after-
meal and bedtime levels. Diabetes Canada has a tool available on its website to help patients determine
how often to test, along with a recommended pattern of testing.10 Testing in these patients has
demonstrated a reduction in HbA1c levels of 0.2–0.6%.6 Testing may also be used to achieve
postprandial glucose targets.9 Additional testing (more than twice daily) may be suggested for patients
with pharmacotherapy changes, those starting a drug that may cause hyperglycemia, or those with an
acute illness.10
Daily blood glucose testing is not recommended for pre-diabetes and for patients diagnosed with
diabetes who are being treated only by diet and lifestyle if they are meeting their glycemic targets.10
Testing
Advise patients to track their results in a journal log, or use meters with memory and graphing options so
they can share this information with their physician and other healthcare practitioners. For optimal self-
monitoring of blood glucose, the patient is educated on the use of a meter, interprets the results and
modifies treatment based on current blood glucose levels according to individual guidelines provided by
healthcare practitioners.9
Encourage patients to adhere to storage directions for test strips, keeping them in their original
containers at room temperature or cooler. Expired and mishandled test strips can lead to errors in
testing. Once a vial of test strips is open, the strips keep longest in a refrigerator (35–50 days), but
deteriorate quickly in direct light and humidity (3–14 days).11
Lancing Devices
The first step in blood glucose monitoring is obtaining a blood sample. A capillary blood sample is
collected by puncturing the skin with a lancet, which is a small needle of varying gauge or size. When the
lancing device is triggered, the needle is projected into the skin and then retracts.
Since patients with diabetes are more susceptible to infection, the area must be well cleansed. Washing
hands with soap and water is acceptable. When travelling, patients can use alcohol swabs instead. Most
lancets are designed to be used 2–4 times.
Most lancing devices have a depth adjustment. The majority of models are pen-shaped and accept a
variety of lancets. However, some lancets can be used only by a specific lancing device. For example,
Softclix devices accept only Softclix lancets.
To use a lancet device, apply the device to the skin, exert gentle pressure and press the trigger. Site
rotation is also important. Frequent users will rotate between fingers; occasionally, right-handed users
might prefer lancing the left hand and vice versa. The target area is the side of the finger beside the
fingernail.
Health Canada recommends against the use of multi-patient lancing devices due to the risk of disease
transmission, even if a new lancet is used for every patient. Only auto-disabling lancet devices should be
used in multi-patient settings.
Alternate Site Testing
Meters are available that allow the use of blood samples from sites other than the fingertip, such as the
forearm, palm of the hand or thigh. During periods of rapid change in BG levels (e.g., after meals, after
exercise and during periods of hypoglycemia), fingertip testing is the most accurate.6 Blood samples
taken from the palm near the base of the thumb provide a closer correlation to fingertip samples than
the forearm or thigh.
Blood Glucose Meters
There are many meters available, and healthcare practitioners can assist patients in choosing an
appropriate device by considering the following factors:
The amount of blood required for the sample

The calibration method: for some models it is as simple as putting in a test strip; others require
pushing a button or inserting a code for calibration
The size of the test strips: patients with poor dexterity may prefer larger strips
The screen size and display size are important to visually impaired patients
The ability to provide an audible readout is important for those who are blind
The battery type and battery life
The ability to link to a computer for in-depth reports
The ability to add comments, such as meals and levels of activity, and access built-in graphs
The ability to communicate with insulin pumps.
Testing with a Blood Glucose Meter
Healthcare practitioners assisting patients with blood glucose meters must have a thorough knowledge
of available products. Demonstrations and detailed owner's manuals are available. As well, a quick
reference guide is available with each meter for rapid consultation. Canadian blood glucose meters are
set to measure glucose in mmol/L and this cannot be changed by the user. To avoid confusion, patients
should be made aware that information designed to the American standard will use units of mg/dL.
Troubleshooting Blood Glucose Meters
Although newer meters are easier to use, patients may still experience difficulties. Many meters provide
directions or error codes that patients or healthcare practitioners can verify in the owner's manual or
discuss with the manufacturer's technical support team.
Most problems are due to:
Errors in user technique

Improper meter calibration. It is important that the meter's calibration number corresponds with the
calibration number on the strip container
Outdated or poorly stored strips. Check manufacturer's specifications regarding temperature, light
and humidity
Inadequacy of blood samples, e.g., size, traces of alcohol used to clean puncture site
Change in patient's situation (e.g., illness, stress, pregnancy), which can produce unexpected but
accurate results
Changes in medications (including adding or discontinuing nonprescription drugs).
Diabetes Management Software
With the appropriate interface, data can be downloaded from a blood glucose meter to a computer. The
software will enable the patient to see the information in different formats, such as patient profiles,
logbooks, means, variations, deviations from pre-set goals, charts, standard day and insulin doses. This
information can also be printed. The software may be available through the manufacturer, or it may be
possible to download the file from the manufacturer's website. Cables to link meters to computers are
available from the manufacturer. Pharmacists may wish to set up their own computer so they are able to
download patients' data and provide interpretive counselling.
Blood glucose values can also be transferred directly to some smart phone apps. In addition to recording
blood glucose data, these apps may include food databases and allow the tracking of diet, exercise
routines and medications.12 Selecting which app to use should be done carefully since they are not
regulated, privacy is not guaranteed and the units of measure in the app may not be compatible with
Canadian standards.
Urine Glucose Monitoring

Ailments—Diabetes Products: Urine Glucose and Ketone Test Kits.
Urinary glucose measurement is not ideal, as it does not reflect current blood glucose levels and will not
detect hypoglycemia. However, there may be select circumstances under which urine glucose monitoring
may be used, such as when blood glucose monitoring is not available, too costly or too painful.
Ketone Monitoring
Ailments—Diabetes Products: Urine Glucose and Ketone Test Kits.
When insulin levels fall too low, the body shifts from carbohydrate to fat metabolism. Ketones are a by-
product of this process. Ketones are normally excreted by the kidneys, but under these circumstances,
elimination is not rapid enough and ketones accumulate in the bloodstream, causing the blood to become
acidic. The levels of blood glucose continue to rise, causing diabetic ketoacidosis (DKA), which is
accompanied by the following symptoms: thirst, dry mouth, frequent urination, nausea and vomiting, blurred
vision, abdominal pain and fruity-smelling breath.
Ketone testing is recommended for those with type 1 diabetes during periods of acute illness accompanied
by elevated BG, when preprandial BG levels are >14 mmol/L, or when symptoms of DKA are present. If all of
these conditions are present in individuals with type 2 diabetes, ketone testing should also be considered.6
During DKA, there is a shift in the equilibrium that is usually present among ketone bodies, favouring the
formation of betahydroxybutyric acid. Blood assays of this acid have been associated with an earlier
detection of DKA than urine testing for acetoacetate or acetone levels.6 Ketones can be detected in urine
using test strips such as Ketostix; to test for ketones in blood, ketone-measuring test strips are used with a
blood glucose meter such as Precision Xtra.
Continuous Glucose Monitoring Systems
Continuous glucose monitoring (CGM) systems have been shown to improve HbA1c levels and reduce
the duration of hypoglycemia, hyperglycemia and nocturnal hypoglycemia in patients treated with
insulin.6 CGM, used in conjunction with intensive insulin regimens, can be a useful tool to lower HbA1c in
selected adults (>25 years) with type 1 diabetes.13 CGM may also be helpful in children.6 CGM may be a
supplemental tool to BG monitoring in those patients with hypoglycemia unawareness and/or with
frequent hypoglycemic episodes.
CGM systems measure glucose levels in interstitial fluids. These levels relate well with BG values,
although there may be significant differences due to lag time, particularly when BG levels are rapidly
changing (such as a few hours after eating). BG tests are still required during these times, for the
purpose of calibrating the CGM system device and for making decisions regarding medication
changes.14
The glucose sensor is a tiny electrode inserted subcutaneously that continuously records glucose levels.
The sensor is worn for up to 3 days before it is discarded and replaced. Glucose readings are transmitted
to a meter or insulin pump where the readings are displayed. Trend reports and charts can be viewed
after the data are downloaded to a computer. Using a CGM system chart is like watching a movie—
anyone can follow the storyline and anticipate what is going to occur next. CGM systems allow patients
and their healthcare practitioners to discover how diet, exercise, medication and lifestyle affect their
glucose levels. CGM system devices that display real-time readings allow patients to see how fast, and
in what direction, their glucose levels are changing, allowing them to intervene earlier to reduce the
frequency and severity of high and low blood sugar episodes.14,15
Insulin Administration Devices

Ailments—Diabetes Products: Insulin Products.
When insulin is administered by injection it is important that patients receive appropriate training in the
device they are using. Consensus guidelines on good injection technique contain tips for optimal insulin
administration.16
Insulin pens look like large fountain pens. Instead of retrieving the insulin from vials, the pen either comes
prefilled with insulin, or uses insulin cartridges. Insulin pens are more convenient and easier to use than
insulin syringes. For the visually impaired, the audible clicks are a useful guide for selecting the correct
number of units to administer.
Once an insulin cartridge is installed into a refillable pen it can be stored between 2–30°C for up to 28 days.
Unused cartridges can be refrigerated and kept until their expiry date. Disposable pens should be
refrigerated until opened, then kept at room temperature (below 30°C) for up to 28–42 days depending on
the insulin brand. Ensure that patients understand the particular technique associated with the use of the
pen. Advise patients to keep a few syringes at home in case of pen malfunction.
There are a number of major companies in the pen/cartridge market and patients must be aware that
cartridges are not interchangeable.
Needles vary in length and diameter. Needle length ranges from 4–12.7 mm. The diameter will vary from
28–33 gauge, with higher numbers indicating a smaller diameter. Thinner and shorter needles cause less
resistance in skin penetration and usually less discomfort for the patient, and are therefore preferred. Some
patients, such as those who are obese, may find longer needles provide better penetration to the
subcutaneous tissue and reduce insulin leakage from the injection site. Waiting 3–5 seconds before taking
a needle out of the skin after injection will help prevent insulin leakage. If 5 seconds is not sufficient, this
interval should be prolonged. Reusing needles diminishes the point sharpness and removes the silicon
coating. This may lead to micro-traumas which are linked to nodule formation; manufacturers recommend
single use only.
Syringes can be used for the administration of insulin but their use has declined significantly with the
introduction of insulin pens. Various sizes and measurement increments are available. The 100-unit size has
2-unit increments for measuring larger doses, while the 50- and 30-unit syringes have 1-unit increments. The
choice of syringes should be based on the total amount of insulin to be administered, keeping in mind that
smaller-volume syringes will offer a more accurate measurement. Occasionally, patients require syringes to
be prefilled with measured insulin doses. Follow appropriate procedures for preparation and storage to
maintain insulin stability.17
Insulin Pumps
An insulin pump is a battery-operated device that is designed to be worn 24 hours a day. A small plunger
pushes insulin out of a reservoir or cartridge through tubing to a cannula that has been inserted in the
patient's subcutaneous tissue.
It can be easier to match insulin requirements with lifestyle (allowing for more flexibility with meals and
activity) using an insulin pump rather than multiple daily doses of insulin. Insulin pumps provide a
constant supply of insulin to the patient, adjustable to the time of day, with the option of providing extra
insulin for meals and snacks.
Advantages of pump therapy:14
Can be used for type 1 diabetes (most common use) or type 2 diabetes
May provide more consistent blood glucose control than daily and multiple daily injections
More convenient than multiple daily injections and allows the patient more flexibility in the timing
and size of meals
Less variation in the rate of insulin absorption (3% vs. 25%) due to fewer injection sites
May result in lower HbA1c values without increasing the risk of hypoglycemia.
Disadvantages of pump therapy:14
An insulin pump can cost between $6000 and $8000, and pump supplies can cost about
$250/month. Many provinces have programs to offset some of these costs
Malfunctions may occur, resulting in ketoacidosis within a few hours due to a disruption in insulin
delivery
Patients need to change their infusion sites every 2–3 days; other considerations include the
requirement for regular skin care and wearing a pump 24 hours a day
Patients must be trained by an experienced diabetes educator and be comfortable with the device
operation.
Pump Features
Insulin pumps are programmed to provide a basal rate of insulin, which can vary for each patient and
at different times of the day. More insulin is usually required at night for those who experience the
dawn phenomenon.
Patients can adjust the pump to provide a bolus amount of insulin according to what and when they
are eating. The insulin pump helps to calculate the dose required based on the number of grams of
carbohydrates eaten, but this can be overridden depending on planned activities or other factors.
Patients must learn the skill of carbohydrate counting. Some meters have a database of favourite
foods, which can make the calculations easier and faster. The pump can also be programmed to
provide the bolus all at once for a regular meal, or over a period of time (e.g., 1–2 hours) when a
patient wishes to nibble.14
Insulin pumps can be linked to a blood glucose meter through wireless technology, and adjustments
to insulin delivery can be made and monitored. The CGM device communicates with the insulin pump
every 5 minutes, showing the direction and rate of change in glucose levels. The advantage of this is
to foresee problems regarding hypo- or hyperglycemia before they arise. The disadvantage of CGM is
that the sensors must be calibrated 2–3 times daily with a blood glucose meter when blood glucose
values are stable. Also, the sensors are expensive and need to be replaced every 3 days.14
The insulin pump may be worn around the abdominal area, or at various other sites including the leg.
The pump contains a reservoir to hold fast-acting insulin. Insulin is withdrawn from a vial and moved
to the reservoir with a needle-attached adapter. The reservoir typically holds 170–300 units of insulin.
The pump can be programmed to set basal rates and bolus settings, along with connectivity to a
glucose meter and/or computer for reporting activity.
An infusion set consists of tubing with either a needle or a cannula to deliver insulin from the pump
to the body. Infusion sets are available with 2 lengths of tubing, ranging from 24 inches (60 cm) to 43
inches (110 cm). These lengths allow users to wear their pumps in a variety of locations. The tubing
needs to be replaced every 3 days. For sc administration, patients have a choice between steel
needles (which must be changed every 1–2 days) or soft Teflon cannula sets (which can be used for
2–3 days). These are available in 2 or 3 lengths and are designed to be inserted either at a 90-degree
angle or at a 30- to 45-degree angle. An autoinjector is available to assist insertions. The 90-degree
insertion provides better penetration for obese patients. Shorter needles can be used (an advantage
for those with needle phobias) but they are more prone to kinking, which may inhibit insulin flow.14
Pharmacists can assist patients who are using pumps by having consumable supplies available.
These include infusion sets, reservoirs, transparent dressings, batteries and adhesive removers.
For information on available insulin pumps, consult the Diabetes Canada website (see Resource
Tips).
Miscellaneous Supplies
Plastic syringe cases allow for the transportation of pre-filled syringes without accidentally applying
pressure to the plunger. They are available for 1 or 7 syringes. This tool is excellent for healthcare
practitioners who pre-fill and deliver insulin to patients with special needs.
Travel kits organize all diabetes needs in one place. Most travel kits contain ice packs, useful for patients
travelling to areas of extreme temperature.
Sharps containers (which are tamper-proof) should be used to dispose of used syringes, needles and
lancets. The containers should be taken to a needle disposal site for safe destruction. There are also
manual and electric needle cutters which retain the exposed needle in a compartment, which when full can
be safely destroyed.
Logbooks can be used by patients to record their blood glucose results, diet and activity level.
Specialized socks provide extra cushioning and warmth while wicking perspiration away from the feet. They
also have loose elastics and no rough seams, so as not to impair circulation or irritate the feet. The long-
term benefit of using these in foot care has not been established.
Callus and blister protectors are also useful for individuals with diabetes, to prevent damage to the skin on
the feet.
Dextrose gels or tablets are a useful means to treat hypoglycemia by providing an exact amount of sugar in
a convenient format. Tablets are recommended over gels because they are faster-acting.
Glucagon is a hormone that counteracts the action of insulin. Glucagon stimulates the release of glucose
from the liver into the bloodstream, thereby easing the symptoms of low blood glucose. Glucagon kits
contain a preloaded syringe, and are mainly for use by family or friends in treating a severe insulin reaction
in patients unable to take sugar by mouth. Seek medical attention for patients not recovering after a few
minutes.
Filling new and refill prescriptions for diabetes medications is a convenient opportunity to ask patients if
they are using and/or require diabetes supplies:9
Alcohol swabs
Blood glucose strips
Glucagon
Glucose tablets
Lancets
Needles/syringes
Needle disposal containers
Pump supplies
Urine ketone strips
Other aids
Resource Tips
American Diabetes Association. Available from: www.diabetes.org.
Diabetes Canada. Available from: www.diabetes.ca.
Diabetes in Control. News and information for medical professionals. Available from:
www.diabetesincontrol.com.
FIT Forum for Injection Technique Canada. Recommendations for best practice in injection technique.
Available from: www.bd.com/resource.aspx?IDX=25063.
Insulin Pumpers. Provides information and support for adults and children with diabetes and their families
interested in insulin pump therapy. Available from: www.insulin-pumpers.org.
Mayo Clinic. Health Information. Available from: www.mayoclinic.com.
Mendosa D. On-line diabetes resources. Part 14: Blood glucose meters. Available from:
www.mendosa.com/meters.htm.
Public Health Agency of Canada. Diabetes. Available from: www.phac-aspc.gc.ca/cd-mc/diabetes-

diabete/index-eng.php.
References
1. Jones H, Berard LD, MacNeill G et al. Canadian Diabetes Association 2013 Clinical Practice
Guidelines for the Prevention and Management of Diabetes in Canada: Self-management education.
Can J Diabetes 2013;37:S26-30. Available from: guidelines.diabetes.ca/Browse/Chapter7.
2. Holman RR, Paul SK, Bethel MA et al. 10-year follow-up of intensive glucose control in type 2
diabetes. N Engl J Med 2008;359:1577-89.
3. The effect of intensive treatment of diabetes on the development and progression of long-term
complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial
Research Group. N Engl J Med 1993;329:977-86.
4. Imran SA, Rabasa-Lhoret R, Ross S. Canadian Diabetes Association 2013 Clinical Practice
Guidelines for the Prevention and Management of Diabetes in Canada: Targets for glycemic control.
5. Tidy C. Self-monitoring in diabetes mellitus. Available from: patient.info/doctor/self-monitoring-in-
diabetes-mellitus.
6. Berard LD, Blumer I, Houlden R et al. Canadian Diabetes Association 2013 Clinical Practice
Guidelines for the Prevention and Management of Diabetes in Canada: Monitoring glycemic control.
7. Ahuja TK, Bai A, Belanger D et al. Systematic review of use of blood glucose test strips for the
management of diabetes mellitus. Ottawa: Canadian Optimal Medication Prescribing and Utilization
Service (COMPUS), Canadian Agency for Drugs and Technologies in Health (CADTH). COMPUS
Optimal Therapy Report 2009;3:1-157.
8. Goldstein DE, Little RR. Monitoring glycemia in diabetes. Short-term assessment. Endocrinol Metab
Clin North Am 1997;26:475-86.
9. American Diabetes Association. Standards of medical care in diabetes–2012. Diabetes Care
2012;35:S11-63.
10. Canadian Diabetes Association 2013 Clinical Practice Guidelines for the Prevention and
Management of Diabetes in Canada: Self-monitoring of blood glucose tool (SMBG) recommendation
tool for healthcare providers. Can J Diabetes 2013;37:S202-3. Available from:
guidelines.diabetes.ca/bloodglucoselowering/smbgtoolpwd.
11. Bamberg R, Schulman K, MacKenzie M et al. Effect of adverse storage conditions on performance of
glucometer test strips. Clin Lab Sci, 2005;18:203-9.
12. El-Gayar O, Timsina P, Nawar N et al. Mobile applications for diabetes self-management: status and
potential. J Diabetes Sci Technol 2013;7:247-62.
13. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Monitoring glycemic
control. Can J Diabetes 2008;32:S32-3.
14. Montopoli T. Pump it up, a pharmacist's guide to insulin pump therapy. Pharmacy Practice 2009
April/May:D6-D9.
15. Medtronic MiniMed. Distinctions between standard glucose meters and glucose sensors. 2006.
16. FIT Forum for Injection Technique Canada. Recommendations for best practice in injection technique.
Available from: www.bd.com/resource.aspx?IDX=25063.
17. Manitoba Pharmaceutical Association. Guidelines for the pre-filling of insulin syringes. Available from:
napra.ca/Content_Files/Files/Manitoba/PreFilling-of-Insulin-Syringes.pdf.
Lifestyle Management and Disease Prevention
L. Maria Gutschi, BScPharm, PharmD

Date of Revision: December 2016
Introduction
Using the knowledge, skills and ability of health professionals, including pharmacists, to improve lifestyle management is becoming
increasingly important. Many drugs are used to treat diseases for which disease prevention strategies and lifestyle management are
also recommended. Healthcare practitioners may have frequent contact with patients who could potentially benefit from lifestyle
modification, so knowledge of these issues helps in providing patients with information, guidance and counselling to prevent disease.
Risk Factors for Mortality in Canada

Developments in public health as well as increased affluence have changed the causes of death in Western countries such as Canada.
Infectious diseases are no longer the major causes of death; the leading causes of death in 20111 were primarily chronic conditions,
specifically:
cancer (29.9%)
cardiovascular diseases (19.7%) and stroke (5.5%)
chronic respiratory diseases (4.6%)
diabetes (3%)
Alzheimer's disease (2.6%)
Acute conditions that were the leading causes of death include:
influenza and pneumonia (2.4%)

accidental death and suicide (5.9%)
Genetic and environmental factors play a role in the risks of chronic diseases; however, much of the variation in the incidence of
chronic conditions may be due to modifiable causes. An analysis of the “actual causes of death” (from external, nongenetic causes),
found that many chronic conditions are often rooted in lifestyle, dietary and metabolic risk factors,2 in particular:
high blood glucose or LDL cholesterol

high blood pressure
overweight or obesity
physical inactivity
poor diet practices
tobacco use
In addition, alcohol use is an important risk factor for road traffic and other injuries, violence, cancers and hemorrhagic stroke.2 Both
excess and insufficient sun exposure are risk factors for preventable disease that is often associated with lifestyle behaviours.3
Since a small number of preventable behaviours and exposures may explain a large proportion of all deaths,2 interventions to increase
smoking cessation, avoid excess alcohol, control high blood pressure, improve diet and increase physical activity are high priorities in
health care.
Obesity
Obesity has reached epidemic proportions in Canada as well as globally; over 2 billion adults worldwide are considered
overweight.4 Epidemic rates of obesity are found in both developed and developing countries and it is a chronic condition with
serious social and psychological dimensions, affecting Canadians of all age and socioeconomic groups. Current surveys reveal
that approximately 62% of the Canadian population is overweight and 25.4% are obese.5 The obesity rate in children has also risen
significantly; the prevalence of obesity in children aged 6–17 years is 8.6% using International Obesity Task Force (IOTF)
definitions. This is important since complications, both physical and psychological, and comorbidities of obesity may begin during
childhood. Being overweight or obese increases the risk of chronic disease and health conditions such as hypertension,
dyslipidemia, insulin resistance, type 2 diabetes, coronary heart disease, stroke, gallbladder and liver disease, osteoarthritis and
sleep apnea.5,6 Less well known is that obesity is associated with cancers such as colon cancer and those that are hormonally
related, particularly prostate, endometrial and breast cancers.4,5,7 Furthermore, obesity is an independent risk factor for all-cause
mortality.5,7,8
Obesity is defined by the WHO as a body mass index (BMI) >30 measured as kg/(height in m)2. A BMI of 40–45 kg/m2 is
associated with a reduced median survival of 8–10 years, comparable to the effects of smoking.9 However, the use of BMI to
assess obesity does not apply to people over 65 or to conditioned athletes.10 Further discussion of obesity and treatment options
can be found in Weight Management.
Visceral adiposity may be a better indicator of increased risk for cardiovascular disease and all-cause mortality.11 Patients at high
risk have a waist measurement of >40 inches (102 cm) for males and >35 inches (88 cm) for females.5,7 Waist circumference cut-
offs for South Asian, Chinese and Japanese ethnic groups are lower.
Physical Inactivity
Seventy-five percent of adults are not active enough to meet Canada's physical activity recommendations, a figure much lower
than estimated using self-reported surveys.12 In addition, a large proportion of children are considered sedentary.
Evidence supporting a physically active lifestyle to improve health is robust. Regular exercise benefits health by increasing
longevity and reducing morbidity and mortality due to coronary heart disease (CHD), stroke, hypertension, obesity, diabetes and
osteoporosis.12,13,14 Exercise also may help with depression15 and improves mental outlook in patients with chronic illness.16
Exercise reduces the risk of colon, prostate and breast cancer.8,13,14 Exercise is beneficial even if the participant is older,17 in
persons with disabilities and significantly protects against cognitive decline.18 Being fit in midlife is associated with significantly
decreased risk of developing a chronic illness in later life.19 Furthermore, the reduction in CHD risk provided by moderate exercise
compares favourably with interventions for smoking, hypertension and high cholesterol levels. If an inactive person becomes
active at age 50, life gain is estimated to be 1.3–3.7 years while those who quit smoking at age 50 are expected to gain 2.3-2.5
years.14 Most importantly, the least fit individuals obtain the most benefit.14 Exercise has been called the miracle drug,20 since
regular physical activity prevents disease and promotes health. Improved physical fitness levels should be a priority for Canadians
of all ages.
Alcohol
The regular intake of alcohol is associated with both benefits and risks.21 Most studies have shown alcohol consumption
demonstrates a J-shaped curve: a lower risk of death in people who are light to moderate drinkers compared with lifetime
abstainers and heavy drinkers.22 Low to moderate doses of alcohol are beneficial for reducing the risk of CHD,21,22 stroke,23 and
diabetes24 compared with no alcohol use. Based on observational trials, health benefits from alcohol consumption are seen only
from middle age and onward and total caloric intake may increase with alcohol consumption without a commensurate increase in
nutritional benefit.22 Cardiovascular benefits can be obtained from as little as one standard drink (13.6 g alcohol or 45 mL spirits,
150 mL table wine, 360 mL beer) every 2 days.
Alcohol consumption is associated in a dose-dependent manner with cancers of the mouth, pharynx, larynx, esophagus and liver.22
Alcohol consumption in persons who smoke increases the rates of these cancers more than the independent effect of either
smoking or drinking alone.25 Doses greater than 50 g/day or 4 standard drinks were significantly associated with the risk of
developing cancer at various sites. Cardiovascular protection due to alcohol is lost at doses greater than 72 g/day (5 standard
drinks/day). Women are at increased risk of harms from both chronic and acute ingestion of alcohol for a given consumption
level.22 Differences in women's physiology (lower body weight, less volume of distribution and smaller livers) may be responsible
for this.
Risk of injury from motor and nonmotor vehicle accidents rises with increasing ingestion of alcohol.22 Sporadic drinking of 5 or
more drinks in a single day leads to worse long-term health outcomes than the same amount spread evenly over several days.22
Alcohol use during pregnancy is associated with fetal alcohol spectrum disorder (FASD).26
Smoking
Smoking is the greatest known cause of avoidable morbidity and mortality and contributes directly or indirectly to 17% of all
deaths in Canada.27
Second-hand smoke is associated with an increased risk of respiratory and heart disease with regular exposure and is estimated
to be responsible for the death of 831 Canadians in 2002.27 Although overall smoking rates in the decade prior to 2012 have
decreased to 16% in people aged 15 years and older, this represents a hard-to-reach group.27 Consumption of other tobacco
products such as cigarillos has increased, especially among youth.28
A recommendation from a healthcare practitioner is one of the most important ways of influencing a patient to consider
quitting.29,30,31 Since it is estimated that most smokers start smoking as teenagers,27 strategies to prevent smoking are as
important as getting patients to quit.
Influenza and Pneumonia

Influenza and pneumonia cause significant morbidity and mortality in patients with chronic medical conditions, particularly in the
elderly (see Viral Rhinitis, Influenza, Sinusitis and Pharyngitis).32,33,34 Vaccination is the most effective method for preventing or
attenuating influenza, yet only 35.8% of adults aged 18–64 years with a chronic medical condition received the influenza vaccine in
2008 in Canada.33 Vaccination rates of non-institutionalized seniors are greater at 66.5% but these rates fall short of the national
target of 80%.33 Emerging research suggests influenza vaccination may provide indirect protection to others in the household or
community.35
Invasive pneumococcal disease is a serious illness, which affects the very young, the elderly and individuals with
immunosuppression or other chronic conditions.36 Vaccination with pneumococcal conjugate vaccine is recommended for
patients undergoing stem cell transplantation, patients with HIV and immunocompromised adults (e.g., asplenia, long-term
immunosuppressive therapy, solid organ transplantation).37 Use of the conjugate pneumococcal vaccine in infants appears to
confer secondary protection in the elderly as a decline in invasive pneumococcal disease has been reported in this population.38
The pneumococcal polysaccharide vaccine is recommended for adults who required medical care for asthma within the last 12
months,39 all immunocompetent adults 65 years of age and older, those <65 years of age in long-term care facilities, persons with
alcoholism, smokers, persons who are homeless and individuals who use illicit drugs.36
Sun Exposure and Vitamin D
Skin cancer is the most frequently diagnosed cancer in Canada and the rate of diagnosis is increasing.40 The Canadian Cancer
Society recommends reduced exposure to the sun, particularly between 11 a.m. and 4 p.m. when the sun's rays are the strongest.
Intermittent, intense sun exposure during childhood or adolescence, along with a history of sunburn, shows the strongest
association with risk of melanoma.
A sunscreen with a sun protection factor (SPF) 15 or higher and SPF 30 for persons who work outdoors or will be outside for most
of the day is recommended. Protection from ultraviolet radiation with hats, sunglasses and clothing that covers most of the skin
should be used40 (see Prevention and Treatment of Sun-induced Skin Damage).
Most Canadians, including children and adolescents, may have insufficient vitamin D levels.41,42 Persons with little sun exposure
such as the elderly, individuals with dark skin and exclusively breastfed babies may be deficient in vitamin D. Sufficient vitamin D
intake through diet alone is impractical and skin exposure to ultraviolet light may be poor due to Canada's northern latitudes and
modern indoor lifestyle. Excessive exposure is associated with skin cancer. Therefore, oral supplementation may be required.
The effects of vitamin D on bone health (lowering risk of fracture) and improved muscle strength (lowering risk of falling) are well
established.43 In addition, epidemiologic evidence of vitamin D deficiency has been associated with a variety of
nonmusculoskeletal diseases including cancer (particularly colon and breast), cardiovascular disease, infectious diseases,
depression, dementia and other conditions.44 However, prospective trials with vitamin D supplements using primary end points of
other health risks, overall cancer rates, cardiovascular disease or mortality are lacking.3 The Institute of Medicine (IOM) concluded
there was insufficient high quality evidence to support supplementation above that required for bone health.45 Further controlled
and randomized trials are required to determine whether low vitamin D intake and stores is a marker of illness and which
Canadians have insufficient vitamin D levels and require supplementation.
Goals of Disease Prevention

Prevent or decrease risk of disease occurrence and minimize the need for future drug therapy
Lower risk of developing some cancers (e.g., breast, colon, prostate, oral, esophageal)
Lower risk of developing cardiovascular disease, diabetes, influenza and pneumonia
Prevent fetal alcohol spectrum disorder
Lower risk of cognitive decline
Patient Assessment
Gather information on lifestyle behaviours to quantify and document:
tobacco use status (never used, ex-user, current tobacco use)

diet and dietary patterns (fruit and vegetable intake, fibre intake, caloric intake)
physical activity (types, quantity, frequency and duration)
alcohol intake (e.g., number of standard drinks/day, occurrence of large amounts at one sitting)
influenza vaccination (e.g., never, sporadically, yearly) and pneumococcal vaccine if indicated
sun exposure habits
A risk assessment tool to determine the impact of lifestyle behaviours associated with increased longevity has been proposed by the
Project Big Life. This self-assessment tool provides patients with information regarding their highest risk behaviour and allows
persons to determine the amount of increased longevity if these behaviours were modified.
Figure 1: Ashwell Shape Chart
a If your shape is in this 'chili' region, you should Take Care. You will not need to decrease your waistline.
b If your shape is in this 'pear' region, you have a healthy OK shape.
c If your shape falls in this 'pearapple' region (particularly the upper end), you should Take Care. Adults over 18 years should consider action,
children over 5 years should take action. Make sure you don't increase your waistline any more.
d If your shape falls into this 'apple' region, your health is probably at risk. Find out what you can do to Take Action.
Adapted from The Ashwell Shape Chart: Are you an apple or a pear? Available from: www.ashwell.uk.com with permission from Ashwell Associates.
In addition to waist circumference cut-offs, the waist to height ratio (WHtR) is an easy-to-use tool for self-assessment of obesity-
related health risks (Figure 1). Although not well known, the WHtR can be used in both children and adolescents46 and as a screening
tool for cardiometabolic risk in both Asian and non-Asian populations.47
Who Can Benefit from Health Promotion and Disease Prevention?
Surveys from the Behavioral Risk Factor Surveillance System show that only 5.1% of people without cardiovascular disease and
7.2% of people with coronary heart disease adhere to the public health promotion recommendations for physical activity, fruit and
vegetable intake and smoking abstinence.48 As a result, most patients will likely benefit from lifestyle modification and disease
prevention behaviours. Examples of how patient presentation may suggest possible lifestyle interventions are shown in Table 1.
Techniques for presenting lifestyle change to patients are discussed later in the chapter.
Table 1: Patient Presentation and Possible Lifestyle Intervention

Patient Presentation Lifestyle Intervention Resource Tip
Chronic headache Regular physical activity Headache, exerciseismedicine.ca
Chronic insomnia Regular physical activity Insomnia, exerciseismedicine.ca
Cough/cold Smoking cessation, flu vaccination Smoking Cessation
Dyspepsia Weight loss and exercise Weight Management, exerciseismedicine.ca
Mild low back pain Regular physical activity Low Back Pain, exerciseismedicine.ca
Osteoarthritis Diet and exercise, and potentially weight loss Osteoarthritis, exerciseismedicine.ca
Patient Presentation Lifestyle Intervention Resource Tip
Osteoporosis Regular physical activity Osteoporosis, exerciseismedicine.ca
Strategies to Improve Lifestyle Management and Disease Prevention

The following strategies are addressed in Table 2.
Weight Control
A multimodal approach including dietary therapy, physical activity and behavioural therapy is essential for weight control.5,61 To
initiate weight loss, a caloric deficit is the goal, while during weight maintenance, caloric intake of food needs to be equivalent to
daily energy expenditure. A caloric deficit of 500 kcal/day should result in a weight loss of 0.5–1 kg per week. Professional help
may be required for continuous monitoring and support. Use of a commercial weight loss program that has been shown to
produce weight loss in trials (e.g., Jenny Craig, Weight Watchers) may be helpful.62 [Evidence: SORT A] Further discussion of
options for weight control can be found in Weight Management.
Unfortunately, dietary interventions for obesity have shown little long-term efficacy, and initial weight loss of 5–10% is often
reversed in 3–5 years regardless of the type of diet utilized.63 However, weight losses of 3–4 kg on average are obtained in dietary
interventions after 2 years;54 this is often a clinically relevant effect. Emphasize eating whole foods such as fruits, vegetables,
whole grains and reducing intake of processed, sugar-sweetened beverages56 and foods high in fat and salt. Both low-fat and low-
carbohydrate diets can produce significant weight loss; recommend a diet the patient can adhere to.58
Table 2: Disease Prevention and Health Promotion for Adults

Disease Prevention Expected Onset of
Strategy Recommendations Benefits Benefit Cautions Comments
Physical activity49,50,51 At least 2.5 h/wk of Reduction in all 3–4 wk for Patients should self- Emphasize the
moderate to vigorous mortality lipid values assess exercise harms of sedentary
aerobic activity in bursts causes 4–6 wk for risks based on their behaviours.
of 10 min or more: Reduced risk of mental health conditions Discourage vigorous
Moderate activity: development of outlook and using the PAR-Q+52 exercise in otherwise
Brisk walking (6 disease and mild (see Resource Tips). sedentary adults.
km/h), skating, bike type 2 DM, HTN, depression Suggest gardening,
riding. Person can CHD 10 y for all- walking, using stairs
talk but cannot sing Reduced risk of cause instead of an
Vigorous activity: stroke mortality elevator, cleaning
Running, basketball, house and
Reduced risk of Benefits lost if
soccer, cross- recreational
obesity exercise not
country skiing. activities.
Reduced risk of continued;
Person cannot
breast and cannot be Walking suggested
speak in full
colon cancer “stored up” for most, as costs
sentences without
are low and no
taking a breath Improved training required.
45–60 min of mental outlook
Indoor walking or
intentional physical Reduced stress treadmills are
activity is
Improved options if weather
preferable.
balance and poor.
Resistance or strength energy Encourage use of
training twice weekly: Improved sleep pedometer.
push-ups, sit-ups, 10-min sessions
Beneficial in
lifting weights, accumulated
some chronic
climbing stairs, throughout the day is
musculoskeletal
digging in the as effective as a
disorders
garden single 30-min
Prevents
bone strengthening session.
cognitive
(walking, running,
decline Additional health
yoga, dance).
benefits seen with
Slows
moderate to
Children and adolescents progression of
vigorous activity for
should engage in at least osteoporosis
>150 min/wk.
60 min per day of
Weight control
moderate to vigorous Total energy
physical activity at least 5 expenditure is most
times weekly. important.
Limit or avoid prolonged
sitting.
Nutrition53,54,55,56,57 Diet high in fruits, Reduced risk of 3–4 wk for Clinical nutritionist Healthy nutrition,
vegetables (6–10 cancers (colon, lipid values or other exercise and weight
servings), fibre, whole esophageal) 1–5 y for CHD, professional with control is key.
grains, rich in omega-3 Reduced risk of DM, stroke specialized Weight loss
fatty acids and protein developing CHD nutritional expertise indicated if BMI >30
sources that are low in for patients with and comorbidity
trans-fat, saturated fat Reduced risk of DM, dyslipidemia
developing type (DM, HTN, sleep
and cholesterol. and CHD, morbid apnea) or abdominal
2 DM obesity.
Sodium intake of ≤1500 obesity as measured
mg/day (approximately 1 Reduced risk of Patients with by waist
tsp of table salt) is also stroke unstable medical or circumference.
recommended. mental illnesses Self assessment of
Caloric intake matched to should be health risks may be
energy expenditure. temporarily accomplished using
excluded from the Ashwell Shape
Mediterranean diet weight loss
associated with Chart (Figure 1).
programs.
increased longevity, Encourage daily
independent of Unintentional weight breakfast, weekly
loss should be weighing and
weight.58,59 referred to a limiting fast food
Limit sugar sweetened physician. intake.
beverages. Evidence for weight
Increase intake of loss in those >60 y
vegetables. Other foods without obesity-
high in polyphenols (e.g., related factors is
green/black tea, lacking.
cocoa/dark chocolate) Weight stability is
may be beneficial. important.
Moderate coffee
consumption (3–4
cups/day) not associated
with health risks and may
be beneficial. Caution in
the elderly, persons with
hypertension and
children.
Tobacco cessation Abstinence Reduced risk of 6 months for None Address concern for
cancer, improvement increase in weight as
including breast in respiratory absolute risk of
cancer symptoms smoking is greater
Reduced risk of 3 y for risk than absolute risk of
CVD including reduction of obesity.
stroke CVD Discuss benefits and
Reduced risk of 10-y risks of smoking
osteoporosis abstinence cessation drugs.
Reduced risk of results in risk

lung diseases reduction of
cancer to
similar to that
of
nonsmokers
Alcohol22,25,26 Low to moderate alcohol Reduced risk of 5–10 y for Consumption Alcohol can
consumption.a CVD achieved benefit of CVD outside low-risk potentiate post-
with in patients >45 guidelines prandial
Abstinence if pregnant. consumption of y associated with: triglyceridemia;
Abstinence while driving approximately 1 Younger Increased risk excessive alcohol
a motor vehicle or boat. drink every patients of cancer intake combined
other day unlikely to (esophageal, with high
benefit liver, mouth, carbohydrate intake
pharynx, can induce
larynx) hypertriglyceridemia.
Increased risk
of
hypertension
impaired social
functioning.
Consult appropriate
healthcare
practitioner if
problem drinking
identified.
Influenza/pneumonia36 Influenza vaccination for: Reduced 2 wk; influenza Contraindications to Pneumococcal

>65 y of age mortality due to vaccination vaccination: vaccination usually
influenza or required yearly egg allergy for given only once.
adults <65 y at high pneumonia
risk of influenza- 2- to 3-wk influenza
related Reduced risk of onset for vaccination
complications, their hospitalization >10 y previous
household contacts, due to these protection pneumococcal
healthcare workers, diseases in with vaccination
and all those patients >65 y pneumococcal
vaccination Address concerns
wishing to be regarding common
protected against vaccination myths.
influenza
immunosuppression
HIV
Pneumococcal
vaccination:
adults ≥65 y
adults <65 at
increased risk of
pneumococcal
disease, i.e., those
with asplenia, sickle
cell disease,
cirrhosis,
alcoholism.
Sun exposure and 1000 IU of cholecalciferol Improved bone 3–5 y for Avoid excessive sun Vitamin D toxicity
vitamin D (vitamin D3) for adults health and cancer risk exposure, does not occur with
supplementation42,43,44 during the fall and winter muscle strength 1 y or longer particularly sun exposure but
months.60 Decreased risk for fracture sunburns. Vitamin D risk of skin cancer
of fracture risk reduction likely safe at total increased with
Children and infants intake of ≤2000 exposure.
should receive 400 Potential and bone
health IU/day. Patients with Sensible skin
IU/day with sensible skin reduced chronic
exposure. mortality from 3–4 wk for exposure of 5–30
granulomatous min, depending on
Patients with inadequate cancer correction of disorders (TB,
insufficiency skin type, of arms
skin exposure due to Potential sarcoidosis, some and legs at half
religious or cultural dress, reduced risk of lymphomas) should minimal erythemal
dark skin or lifestyle, respiratory be referred for
assessment by doseb can provide
malabsorption diseases
appropriate 400 IU of vitamin D.
syndromes, obesity,
chronic kidney disease healthcare Exposure to 1
are at higher risk. practitioner. minimal erythemal
Doses >50 000 IU dose in a swimsuit
per day are during the hours of
associated with 10:00 a.m. to 3:00
hypercalcemia and p.m. can provide the
hyperphosphatemia. equivalent of
10 000 IU of vitamin
D.
a Defined as ≤9 standard drinks per week for females or ≤14 standard drinks per week for males.
b Defined as amount of sunlight exposed before skin turns slightly red.
Abbreviations BMI = body mass index; CHD = coronary heart disease; CVD = cardiovascular disease; CSF = cerebrospinal fluid; DM = diabetes
mellitus; HTN = hypertension; HIV = human immunodeficiency virus; MI = myocardial infarction; PAR-Q = physical activity readiness
questionnaire; SBP = systolic blood pressure; TB = tuberculosis
Nutrition for Disease Prevention
Principles for nutrition include:
eating a balanced proportion of food from different food groups

eating a wide variety of foods from each food group
eating in moderation
Canada’s Food Guide recommends that carbohydrates comprise 45–55%, protein 10–35% and fat 20–35% of calories in the diet.
The diet should be low in saturated fat, sugar and salt. Vegetables, fruits and grains are emphasized.64
The Mediterranean diet pyramid has been shown to improve mortality and morbidity in the secondary prevention of coronary artery
disease, even if no weight loss occurs.58,65 This diet is high in legumes, minimally processed whole grain products, fruits,
vegetables, nuts and fish, and low in red and processed meat and dairy products. Olive oil is the major source of lipids. For
prevention of disease, higher adherence to all aspects of the Mediterranean diet is associated with a lower risk of mortality,
cardiovascular disease or mortality, cancer incidence or mortality and neurodegenerative diseases.59 Nut consumption was
associated with reduced CV risk as part of the Mediterranean diet59 and has not been associated with weight gain if used as a
replacement to other foods.66
The Dietary Approaches to Stop Hypertension (DASH) diet is a proven dietary pattern to treat hypertension. High fiber foods,
vegetables, fruits and low-fat dairy products are emphasized while sodium, sweets, red meats and sugar-sweetened beverages are
discouraged.67
The American Cancer Society also recommends a diet high in fruits and vegetables, a healthy weight and physical activity to
reduce cancer risk.8
Green tea and cocoa contain polyphenolic flavanoids; green tea consumption in particular is associated with decreased CV and
stroke risk.57
Physical Activity
Promote regular moderate physical activity to virtually all patients. Populations who may particularly benefit are cancer survivors,
the elderly and those with chronic medical conditions. To identify potential risks, individualized exercise recommendations must
be preceded by patients completing the revised PAR-Q+ which stratifies patients into low, intermediate (moderate) and high-risk
categories.
For general or low risk patients the questions are:52
Has your doctor ever said that you have a heart condition or high blood pressure?
Do you feel pain in your chest at rest, during your activities of daily living, or when you do physical activity?
Do you lose your balance because of dizziness, or have you lost consciousness in the last 12 months? (Please answer no if
your dizziness was associated with over-breathing, including during vigorous exercise).
Have you been diagnosed with another chronic medical condition? (other than heart disease or high blood pressure).
Are you currently taking prescribed medications for a chronic medical condition?
Do you have a bone or joint problem that could be made worse by a change in your physical activity? (Please answer no if you
had a joint problem in the past but it does not limit your current ability to be physically active).
Has your doctor ever said that you should only do medically supervised physical activity?
Patients who have answered no to all of the questions are cleared for physical activity and can exercise at moderate intensities
with minimum supervision. If any of these questions are answered in the positive, the patient should be referred to the electronic
Physical Activity Readiness Medical Examination (ePARmed-X+) available from eparmedx.com/. This online assessment tool
further stratifies patients into intermediate or high risk and provides specific recommendations for physical activity and need for
professional guidance and/or medical supervision. Most patients with relative contraindications can still exercise, but at lower
levels of intensity; the risk of an adverse event related to exercise is very low even in those living with a chronic condition.52
Patients should be clearly told to stop exercising and seek medical attention if they develop chest pain, light-headedness, or
palpitations.
Moderate to vigorous aerobic activity is recommended in adults, including older adults, in order to achieve health benefits.51
Moderate physical activity such as brisk walking (defined as 5–6 km/h or 3–4 mph), cycling, yoga or noncompetitive swimming is
sufficient to reduce the risk of cardiovascular mortality and confers many other benefits, but more activity produces more
benefits.13,14,51 Resistance training or muscle-strengthening exercises are also recommended at least twice weekly for
maintaining muscle mass and bone health and older adults should perform physical activity to maintain balance and prevent
falls.51 Combining aerobic activities of differing types and intensities, such as housekeeping, leisure and recreational activities is
appropriate. It is important to know that a large volume of physical activity is required for weight loss if there is no concomitant
caloric deficit. For weight maintenance, however, regular moderate amounts of intentional physical activity are required.
Success should be evaluated according to improvements in chronic disease factors or symptoms and by adopting healthy lifestyle
habits, not by weight loss alone.13,14 Despite little or no weight loss, increased exercise decreases visceral adiposity68 and
decreases mortality.13,14,19,51 More physical activity provides greater health benefits but even 15 minutes/day may increase
longevity compared to inactivity.49 Exercise is also beneficial for maintaining flexibility and decreasing health risks in those who
are sedentary or have significant limitations in their ability to exercise.13 However, activity of moderate intensity and duration is
required to achieve specific health outcomes such as reduction in the risk of type 2 diabetes.
Children are also encouraged to participate in moderate to intensite physical activity every day and to minimize sedentary
behaviours such as screen time and time spent in sedentary transport.51
Pedometers provide an accurate, objective measure of walking and other ambulatory activity (see Table 3); for an average person
2000 steps is the equivalent of a 1.6-km (1-mile) walk. Pedometer-measured activity has shown Canadian adults average
approximately 9000 steps/day,12 which is considered a somewhat active lifestyle. Although the use of pedometers can increase
physical activity over baseline and they are used to set and keep goals, current evidence suggests that pedometer use results in
only modest increase in walking behaviours and weight loss.69 However, this may be sufficient to limit weight re-gain.
Table 3: Pedometer-measured Activity

Number of Steps per Day Lifestyle Category
<5000 Sedentary
5000–7499 Low active (typical of daily activity excluding sports/exercise)
7500–9999 Somewhat active
≥10 000 Active
Primary care providers are using prescriptions for exercise, using validated tools. These tools may be accessed at
exerciseismedicine.ca and are safe for healthy adults and those with stable chronic conditions. The tool includes the frequency,
intensity, type and time format for exercise, and can include a referral to an exercise specialist. The addition of very accurate
piezoelectrical pedometers to an exercise prescription can be useful, especially for those who ambulate at slower speeds like the
elderly.70 The Piezo Step Rx Series pedometer is classified as a medical device and maybe included as an insurable benefit.
Pharmacists can initiate or support exercise prescriptions in their patients, display signage and provide appropriate pedometers to
support these initiatives.
Vitamin D Supplementation
The optimal dietary requirement for vitamin D in healthy adults is currently evolving. Vitamin D is naturally present in very few
foods, mainly fatty fish and egg yolks. The major sources of vitamin D in Canada are fortified foods such as cow's milk, soy
beverages and calcium-fortified orange juice.64 Endogenous vitamin D is produced in the skin with exposure to ultraviolet light but
virtually none is produced during the winter months in Canada. To improve bone health, the recommended Dietary Reference
Intakes (DRIs) for vitamin D are 600 IU (15 μg) for men and women aged 1–70 years and 800 IU (20 µg) for people older than 70
years.71 Although more data are required to define optimal blood and intake levels, based on emerging data the Canadian Cancer
Society recommends supplementation with 1000 IU of vitamin D (cholecalciferol) daily during the fall and winter to reduce the risk
of breast, colon and prostate cancer.60 In Canada, exclusively breastfed infants <1 year of age should receive 400 IU of vitamin D
per day. Without adequate sun exposure, children and adults may require approximately 800–1000 IU per day.71 Skin exposure of
arms and legs for 5–30 minutes between 10 a.m. and 3 p.m. twice weekly is sufficient for vitamin D synthesis. However, because
of the risks of ultraviolet radiation, a balanced diet, supplementation and limited skin exposure are the preferred methods of
obtaining vitamin D. See Nutritional Supplements for more information.
Immunization
Encourage pneumococcal vaccination in those at high risk. Refer to the Canadian Guidelines for Immunization by the National
Advisory Committee on Immunization (NACI)36 for further recommendations on pneumococcal vaccinations for infants and
children. Review whether the patient is a candidate for other recommended vaccines such as tetanus.
Tobacco Cessation
Ask for the smoking status of patients and document this in the patient's profile. Recommend and initiate smoking cessation
programs as appropriate (see Smoking Cessation). Recommend stopping other tobacco products.
Alcohol
Encourage low-risk drinking for patients who drink alcohol, and in particular those who are receiving drugs known to have
potentiating effects with alcohol. Patients who abstain from alcohol should not be encouraged to start drinking for its
cardiovascular benefits, as there are other options and they may have a reason for abstinence. Inform all pregnant women of the
risks of alcohol consumption and FASD. Emphasize abstinence in this population.21 Consult the Society of Obstetricians and
Gynaecologists of Canada website for more information.
Approaches to Health Behaviour Change

A high degree of awareness exists among the Canadian population regarding strategies for disease prevention and lifestyle
modifications, and patients are very interested in preventive care.72,73 However, long-term improvements in dietary changes and
physical activity levels have been hard to achieve5,14,54 although smoking rates have fallen over the last decade.27
Effective approaches to improve lifestyle among patients are not yet established despite evidence of specific targets for physical
activity, smoking and dietary behaviours known to improve longevity and decrease morbidity.74 According to several behavioural and
social theories, health promotion interventions that include interpersonal, intrapersonal, organizational and environmental factors may
be more effective than those that focus solely on individuals.74,75
Population-based
Public health agencies, workplace integration, recreation, planning and regional, national and international partnerships have been
suggested to increase physical activity levels at the population level.75 This approach was successful in decreasing smoking rates.
Population-based strategies include media and educational campaigns, labeling and consumer information, economic incentives,
school and workplace approaches, local environmental changes and direct restrictions and mandates.75 Decision prompts
encouraging the use of stairs versus elevators are one example of a successful public strategy.76
Individual-based
Strategies to assist clinicians in lifestyle management in the ambulatory setting have been proposed in 3 broad categories:77
appropriate ways to discuss lifestyle changes including body weight

multidisciplinary collaboration
information technology strategies.
Approaching the Patient

Discussions with patients should always include the medical consequences of unhealthy lifestyle behaviours and should be
delivered in a respectful and nonjudgemental manner. Emphasizing the harms of inactivity for example, instead of the benefits,
has been suggested as a strategy to increase physical activity.78
Brief, effective interventions are often successful.79,80,81 A new diagnosis of a chronic disease with a new prescription for drug
therapy or other important life events can be a catalyst, increasing the likelihood that patients themselves identify the need for
a lifestyle change.81
The model used for brief advice regarding smoking cessation has been adapted for health behaviours, including advice on
lifestyle:77
Ask (Do you perform physical activity regularly? Have you been told you have weight-related diseases?)
Assess readiness for change (Are you interested in increasing physical activity?)
Advise (Provide specific detailed information with an end point and time frame. Define small achievable goals)
Assist (Identify barriers, personalize lifestyle changes, provide information and goal setting)
Follow up (Include plans for self-monitoring, reinforcement and follow up).
Validated practical tools to assess diet and lifestyle that are quick to use may provide an efficient and accurate assessment of
eating and physical activity behaviours.82,83
Multidisciplinary Collaboration/Multi-component Program
Programs to deliver lifestyle interventions usually consist of a weight loss goal of >5% of body weight, an increase in
physical activity to at least 150 minutes/week, and a psychosocial intervention. A portion-controlled diet during the initial
phase, then behavioural techniques, diet modification, physical activity and social support are the usual components of a
lifestyle intervention. These programs do improve weight loss but effects wane over time.84 Since intense lifestyle
interventions require significant human resources, ongoing intervention and support are usually required, as is true with all
chronic diseases.
Internet and Other Technologies
Since lifestyle interventions are a large component of primary care, technologies that can affect human resource and time
constraints have generated much interest.
Most Internet-based lifestyle interventions include:77

education about diet, physical activity, weight loss and maintenance
self-monitoring
individual goal setting
motivation enhancement through online or electronically by a counsellor
peer social support.
Internet behavioural weight loss programs with email counselling, or on-line support have been found to be effective in weight
loss programs.85 Mobile or digital health interventions have been used to improve CVD outcomes86 including hypertension,
increase smoking cessation rates,87 and to improve physical activity and dietary recommendations.88
Online lifestyle interventions generally work as well as face-to-face interventions,85 even in those older than 50 years.89
However, long-term effects, potential risks and possible limitations to these approaches require further study.
Monitoring the Patient for Lifestyle Changes

Self-monitoring is important for lifestyle change as it is for any chronic condition.Table 4 provides a framework that requires
individualization. Provide reinforcement with written or technology based plans and logs for self-monitoring, as this has been found to
be useful especially for nutrition and exercise recommendations.13
Table 4: Monitoring of Disease Prevention and Health Promotion

Lifestyle Change Monitoring Endpoint Actions
Weight loss and nutrition Patient: Weight weekly Decrease in 5–10% of body If ineffective, consider referral to a
while on diet, monitor fit weight over 6 months. formal weight management
of clothing, increased program and/or dietitian.
mobility, reduced drug If effective, moderately vigorous
requirements exercise recommended to prevent
Healthcare practitioner: weight regain.
After 3–6 months
Lifestyle Change Monitoring Endpoint Actions
Exercise Patient: Daily using 2.5 h/wk moderate intensity: Start with 10 min per day, slowly
activity logs/electronic walking at 6 km/h or 4 mph increasing by 10 min, every 8–10
methods and pace spread out into wk in elderly or sedentary patients.
pedometers, increased sessions of 10 min or more. If walking, set goals, using a
stamina, flexibility and Muscle strengthening pedometer, of an increase of 2000–
energy exercise twice weekly such 3000 steps a day over baseline; aim
Healthcare practitioner: as climbing stairs, lifting for 8000–10 000 steps per day if
After 8–12 wk weights or yoga. no functional limitations, lower
amounts in the elderly or very
sedentary.
If ineffective, refer to other
community resources.
Smoking See Smoking Cessation
Alcohol Patient: Weekly intake Alcohol intake within low- If ineffective, counsel to stage of
Healthcare practitioner: risk guidelines. change (see Facilitating Behaviour
after 3–6 months Change).
If problem drinking (impaired social
functioning), refer for further
assessment and treatment.
Sun exposure and vitamin Patient: Daily intake; limit No sunburn or excessive Supplementation with vitamin D
D supplementation exposure to sun during exposure. during winter months is suggested
peak hours in summer for patients >50 y.
Healthcare practitioner:
after 3–6 months
Influenza/pneumococcal Patient: In the fall for Yearly immunization with If ineffective, record in patient
vaccines influenza via pharmacy influenza, once for profile for recommendation the
or clinic, at any time for pneumococcal vaccine. following year.
pneumococcal Assess and address reasons for
Healthcare practitioner: nonvaccination, counsel to stage of
In the fall for influenza, at change.
any time for
pneumococcal
Resource Tips
Smart Phone Applications:
Fitbit. Available from: www.fitbit.com/product/mobile/iphone.
Lose It. Available from: www.loseit.com.
MyFitnessPal. Available from: www.myfitnesspal.com/mobile.
SparkPeople. Available from: www.sparkpeople.com/mobile-apps.asp.
Web Sites:
Exercise is Medicine Canada. Available from: exerciseismedicine.ca
Mediterranean Diet Pyramid. Available from: oldwayspt.org/sites/default/files/images/Med_pyramid_flyer.jpg.
Pace Canada. Health provider’s guide to counseling for healthy active living. Available from:
www.idocc.ca/Guideline/References/23_PACE_Guide_for_Healthy_Active_Living.pdf.
PAR-Q+ and eParmed-X+ Online. Available from: eparmedx.com.
Physical Activity Line. Available from: www.physicalactivityline.com.
Project Big Life. Health calculators. Life expectancy. Available from: www.projectbiglife.ca/life/.
Simple Lifestyle Indicator Questionnaire and its scoring scheme. Available from: www.cfp.ca/content/54/1/76/F1.expansion.html
Suggested Reading
Suggested Reading
Canadian Society for Exercise Physiology. Canadian physical activity and sedentary behaviour guidelines handbook. Available from:
csep.ca/CMFiles/Guidelines/CSEP_Guidelines_Handbook.pdf.
Health Canada. Eating well with Canada's food guide. Available from: www.hc-sc.gc.ca/fn-an/food-guide-aliment/index-eng.php.
Lenz TL. Lifestyle modifications in pharmacotherapy. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2008.
References
1. Statistics Canada. The 10 leading causes of death, 2011. Available from: www.statcan.gc.ca/pub/82-625-
x/2014001/article/11896-eng.htm. Accessed April 21, 2015.
2. Danaie G, Ding EL, Mozaffarian D et al. The preventable causes of death in the United States: comparative risk assessment of
dietary lifestyle, and metabolic risk factors. PLoS Med 2009;6:e1000058.
3. Goodwin PJ. Vitamin D in cancer patients: above all, do no harm. J Clin Oncol 2009;27:2117-9.
4. World Health Organization. Obesity and overweight. Fact sheet no. 311. Geneva: WHO; 2015. Available from:
www.who.int/mediacentre/factsheets/fs311/en/. Accessed June 4, 2015.
5. Public Health Agency of Canada. Obesity in Canada. Available from: www.phac-aspc.gc.ca/hp-ps/hl-mvs/oic-oac/intro-
eng.php. Accessed April 21, 2015.
6. Roberts KC, Shields M, de Groh M et al. Overweight and obesity in children and adolescents: results from the 2009 to 2011
Canadian Health Measures Survey. Available from: www.statcan.gc.ca/pub/82-003-x/2012003/article/11706-eng.htm.
Accessed June 19, 2015.
7. Lau DC, Douketis JD, Morrison KM et al. 2006 Canadian clinical practice guidelines on the management and prevention of
obesity in adults and children [summary]. CMAJ 2007;176:S1-13.
8. Kushi LH, Doyle C, McCullough M et al. American Cancer Society Guidelines on nutrition and physical activity for cancer
prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 2012;62:30-67.
9. Prospective Studies Collaboration et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative
analyses of 57 prospective studies. Lancet 2009;373:1083-96.
10. Douketis JD. Body weight classification. CMAJ 2005;172:1274-5.
11. Staiano AE, Reeder BA, Elliott S et al. Body mass index versus waist circumference as predictors of mortality in Canadian
adults. Int J Obes 2012;36:1450-4.
12. Statistics Canada. Directly measured physical activity of adults, 2012 and 2013. Available from: www.statcan.gc.ca/pub/82-625-
x/2015001/article/14135-eng.htm. Accessed April 27, 2015.
13. Warburton DE, Charlesworth S, Ivey A et al. A systematic review of the evidence for Canada's Physical Activity Guidelines for
Adults. Int J Behav Nutr Phys Act 2010;7:39.
14. Lee IM, Shiroma EJ, Lobelo F et al. Effect of physical inactivity on major non-communicable disease worldwide: an analysis of
burden of disease and life expectancy. Lancet 2012;380:219-29.
15. Rimer J, Dwan K, Lawlor DA et al. Exercise for depression. Cochrane Database Syst Rev 2012;7:CD004366.
16. Herring MP, Puetz TW, O'Connor PJ et al. Effect of exercise training on depressive symptoms among patients with a chronic
illness: a systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 2012;172:101-11.
17. Chou CH, Hwang CL, Wu YT. Effect of exercise on physical function, daily living activities, and quality of life in the frail older
adults: a meta-analysis. Arch Phys Med Rehab 2012;93:237-44.
18. Sofi F, Valecchi D, Bacci D et al. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern
Med 2011;269:107-17.
19. Willis BL, Gao A, Leonard D et al. Midlife fitness and the development of chronic conditions in later life. Arch Intern Med
2012;172:1333-40.
20. Pimlott N. The miracle drug. Can Fam Physician 2010;56:407, 409.
21. Bondy SJ, Rehm J, Ashley MJ et al. Low-risk drinking guidelines: the scientific evidence. Can J Public Health 1999;90:264-70.
22. Butt P, Beirness D, Gliksman L et al. Alcohol and health in Canada: a summary of evidence and guidelines for low-risk drinking.
Ottawa: Canadian Centre on Substance Abuse. Available from: www.ccsa.ca/Resource%20Library/2011-Summary-of-
Evidence-and-Guidelines-for-Low-Risk%20Drinking-en.pdf. Accessed April 27, 2015.
23. Berger K, Ajani UA, Kase CS et al. Light-to-moderate alcohol consumption and the risk of stroke among U.S. male physicians. N
Engl J Med 1999;341:1557-64.
24. Howard AA, Amsten JH, Gourevitch MN. Effect of alcohol consumption in diabetes mellitus: a systematic review. Ann Intern
Med 2004;140:211-9.
25. Bagnardi V, Blangiardo M, La Vecchia C et al. Alcohol consumption and the risk of cancer: a meta-analysis. Alcohol Res Health
2001;25:263-70.
26. Cook JL, Green CR, Lilley CM et al. Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan. CMAJ
2016;188(3):191-7.
27. Health Canada. Canadian Tobacco Use Monitoring Survey (CTUMS), 2012. Available from: www.hc-sc.gc.ca/hc-ps/tobac-
tabac/research-recherche/stat/ctums-esutc_2012-eng.php. Accessed April 25, 2015.
28. Physicians for a Smoke-Free Canada. Cigarillo smoking in Canada: a review of results from CTUMS, Wave 1-2007. Ottawa:
Physicians for a Smoke-Free Canada; 2008. Available from: www.smoke-free.ca/pdf_1/cigarillos-2008.pdf. Accessed
November 26, 2009.
29. Stead LF, Bergson G, Lancaster T. Physician advice for smoking cessation. Cochrane Database Syst Rev 2008;(2):CD00165.
Assessment of Patients with Abdominal Pain
Peter Thomson, BSc(Pharm), PharmD

Introduction
Abdominal pain is a nonspecific symptom arising from a variety of sources both within and external to
the GI tract. Virtually everyone experiences abdominal symptoms on an intermittent basis, which can
have an impact on both personal and societal resources (e.g., dyspepsia alone can account for 5% of
family physician visits1). Fortunately, the vast majority of symptoms are benign in nature.
Pathophysiology
Excluding an acute abdomen, sites within the GI tract that contribute to the majority of GI complaints
include the esophagus (e.g., GERD), stomach (e.g., peptic ulcer disease), liver (e.g., hepatitis), gallbladder
(e.g., cholelithiasis), pancreas (e.g., pancreatitis) and intestines (e.g., abdominal hernia, cancer of the
colon, constipation, diverticulitis, inflammatory bowel disease, lactose intolerance).
Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders of the GI
tract; these are prevalent in both the adult and pediatric populations. Formal classification of functional
GI disorder subtypes can be found in the ROME III criteria.2
Although not a requirement, pain and abdominal discomfort due to IBS are more often localized below
the umbilicus in combination with alteration in the frequency of bowel movements and/or consistency of
the stool, whereas symptoms of dyspepsia usually arise from the epigastrium and include heartburn,
reflux, pain (or discomfort) and nausea. IBS and FD are not likely to increase the risk of pathologic GI
disorders yet they may significantly impair quality of life and increase utilization of healthcare resources.
Together they can account for roughly half of all referrals to outpatient gastroenterology clinics.3
There are a number of evidence-based guidelines for the assessment and management of dyspepsia in
adults.1,4,5,6 In general, the goal is to ensure that those with serious GI pathology seek prompt
investigation and treatment and to minimize overuse of diagnostic investigations unlikely to provide
useful information.5,7,8
Patient Assessment
Indications of Serious GI Pathology
Individuals presenting with common symptoms associated with serious GI pathology should seek
timely medical attention. In a study of over 150 patients who developed gastric or esophageal cancer
under the age of 55 years, over 97% had at least 1 the following serious signs and symptoms:
dysphagia, weight loss (>3 kg over 6 months), persistent vomiting, bleeding, anemia, hematemesis or
melena.9 Additional “red flags” include: age >50 years (especially if new onset dyspepsia or recent
change in symptoms), jaundice, cancer history (strong family history) and multiple treatment failures.
Fever and chills can represent an infectious source of abdominal pain requiring medical assessment
(see Figure 1).
Assessment of Patient Acuity
Obtain a detailed medical history from the person with abdominal pain, to narrow the possibilities to a
few key potential diagnoses. Key assessment issues include location, duration, severity and triggers
of pain, comorbid medical conditions and medication use. If no signs of serious GI pathology are
apparent, undertake a systematic assessment of abdominal pain. Acute (<24 hours), well-localized,
moderate or severe pain worsening over hours and tender to touch usually indicates a need for
medical attention. Triggers of pain such as medications and foods may suggest specific disorders
such as peptic ulcer disease (PUD), GERD, lactase deficiency or celiac disease. Intolerance to foods
can also give rise to abdominal pain. Spicy foods, citrus fruits and foods with a high fat content are
examples. Postprandial pain is often associated with overindulgence. High fat intake and certain
foods can produce indigestion and trigger symptoms of IBS. Review timing of pain with meals and
current medications (including herbals and vitamins). Evaluate alcohol and recreational drug use (if
appropriate). Certain disease states such as renal failure and heart failure may cause abdominal
pain. Frequently, pain is diffuse in nature in these conditions.
Medications are commonly associated with epigastric abdominal pain (Table 1) and the presence of
medication-induced dyspepsia is not necessarily indicative of GI pathology such as bleeding.
Comorbid diseases can produce or mimic abdominal pain and may warrant further assessment (e.g.,
ischemic heart disease, psychiatric disorders). Particular attention should be given to patients using
immunosuppressive medications such as systemic corticosteroids, in whom the symptoms of
clinically important GI disease may be attenuated. Extremes in age (very elderly, infants <1 month
old) are often at risk of rapid decompensation and require closer evaluation and monitoring.10
Table 1: Selected Medications Commonly Associated with Abdominal Pain

Amiodarone (especially Antiretrovirals Opioids
loading dose) Dabigatran Sildenafil (especially in the
Antibiotics Iron salts treatment of pulmonary
Antiepileptic drugs hypertension)
Metformin
Antineoplastics SSRIs
NSAIDs, ASA and other
Antipsychotics antiplatelet agents Sulfasalazine
Location of Abdominal Pain
Pain is often, but not always, localized to different areas of the abdomen. Localization often helps
determine the most likely causes of the pain. It may also assist in assessing when to refer a patient
for medical care. Pain commonly arises from the epigastric, periumbilical or pelvic regions as well as
from the right, left, upper and lower quadrants. More common causes of epigastric pain include
GERD, PUD, FD and pancreatitis (the latter also causes back pain). Right upper quadrant pain often
involves the liver or gallbladder but can also include pancreatitis. Acute onset of severe right upper
quadrant pain usually requires medical assessment, as this may be a sign of biliary colic,
cholecystitis or biliary obstruction. Left upper quadrant pain may involve the spleen but can also
include epigastric and musculoskeletal sources of abdominal pain. Periumbilical pain may be due to
gastroenteritis or inflammatory bowel disease (IBD) in addition to IBS. Causes of right lower quadrant
pain include appendicitis, IBD, IBS and pelvic organs. Small bowel obstruction, IBD, IBS and pelvic
inflammatory disease (or ectopic pregnancy) can appear as either right or left lower quadrant pain.10
Caveats to Abdominal Pain Assessment
In many cases, the cause of abdominal pain varies with patient age as well as comorbid medical
conditions. There is a considerable overlap in symptoms among many of the common disorders that
cause abdominal pain. For example, over 80% of patients with IBS will also exhibit symptoms of
dyspepsia.11 Moderate to intense pain is not a characteristic feature of dyspepsia. In biliary tract
disease and pancreatitis, the pain is usually acute and more intense in nature.11
Recurrent periumbilical abdominal pain occurs in various intensities in approximately 10% of school-
aged children. Nausea and vomiting may also occur but weight loss is uncommon. In over 90% of
cases there is no organic cause. Stress (e.g., school) may be a component. Drug therapy is generally
not recommended.12
Algorithms
Figure 1: Assessment of Patients with Chronic Abdominal Pain
dysphagia- difficulty in
swallowing
Abbreviations: AAA = abdominal aortic aneurysm; CRC = colorectal cancer; FD = functional dyspepsia; IBD
= inflammatory bowel disease; IBS = irritable bowel syndrome; IHD = ischemic heart disease; LLQ = left lower
quadrant; LUQ = left upper quadrant; MSK = musculoskeletal; PID = pelvic inflammatory disease; RLQ = right
lower quadrant; RUQ = right upper quadrant
Suggested Readings
Gans SL, Pols MA, Stoker J et al. Guideline for the diagnostic pathway in patients with acute abdominal
pain. Dig Surg 2015;32:23-31.
Marsicano E, Vuong GM, Prather CM. Gastrointestinal causes of abdominal pain. Obstet Gynecol Clin
North Am 2014;41:465-89.
References
1. National Institute for Health and Care Excellence (NICE). Gastro-oesophageal reflux disease and
dyspepsia in adults: investigation and management. NICE guidelines [CG184]; November 2014.
Available from: www.nice.org.uk/guidance/cg184. Accessed February 25, 2016.
2. Rome Foundation. Appendix A: Rome III diagnostic criteria for functional gastrointestinal disorders.
Available from: www.romecriteria.org/assets/pdf/19_RomeIII_apA_885-898.pdf. Accessed
February 25, 2016.
3. Jones J, Boorman J, Cann P et al. British Society of Gastroenterology guidelines for the
management of the irritable bowel syndrome. Gut 2000;47:ii1-19.
4. Talley NJ; American Gastroenterological Association. American Gastroenterological Association
medical position statement: evaluation of dyspepsia. Gastroenterology 2005;192:1753-5.
5. Veldhuyzen van Zanten SJ, Flook N, Chiba N et al. An evidence-based approach to the
management of uninvestigated dyspepsia in the era of Helicobacter pylori. Canadian Dyspepsia
Working Group. CMAJ 2000;162:S3-23.
6. Mason JM, Delaney B, Moayyedi P et al. Managing dyspepsia without alarm signs in primary
care: new national guidance for England and Wales. Aliment Pharmacol Ther 2005;21:1135-43.
7. Suzuki H, Nishizawa R, Hibi T. Therapeutic strategies for functional dyspepsia and the
introduction of the Rome III classification. J Gastroenterol 2006;41:513-23.
8. Veldhuyzen van Zanten SJ, Bradette M, Chiba N et al. Evidence-based recommendations for
short- and long-term management of uninvestigated dyspepsia in primary care: an update of the
Canadian Dyspepsia Working Group (CanDys) clinical management tool. Can J Gastroenterol
2005;19:285-303.
9. Gillen D, McColl KE. Does concern about missing malignancy justify endoscopy in uncomplicated
dyspepsia in patients aged less than 55? Am J Gastroenterol 1999;94:75-9.
10. Millham FH. Acute abdominal pain. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and
Fordtran’s gastrointestinal and liver disease: pathophysiology, diagnosis, management. 10th ed.
Philadelphia: Saunders/Elsevier; 2016. p 161-74.
11. Tack J. Dyspepsia. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's
gastrointestinal and liver disease: pathophysiology, diagnosis, management. 10th ed. Philadelphia:
Saunders/Elsevier; 2016. p. 183-96.
12. Hay WW. Recurrent abdominal pain. In: Hay WW, Hayward AR, Levin MJ et al., eds. Current
pediatric diagnosis and treatment. 14th ed. Old Tappan: Appleton & Lange; 1999. p. 550-2.
Constipation
Jane Bowles-Jordan, BScPhm, CDE

Peer Review Date: April 2016
Pathophysiology
Constipation is generally defined as defecation fewer than 3 times per week accompanied by other symptoms including hard
stools, feeling of incomplete evacuation, excessive straining, a sense of rectal blockage and abdominal discomfort, bloating
and distention.1 Some patients incorrectly believe that a daily bowel movement is necessary and that anything less means
they are constipated. In fact, the average number of bowel movements for adults and children 3 years of age or older in the
Western world varies from 3 daily to 1 every 3 days.2,3
Constipation can be a symptom secondary to a drug or disease (see Table 1).4,5,6,7 Chronic constipation that does not have
drug, anatomic or physiologic causes is termed functional or chronic idiopathic constipation and is defined by the ROME III
criteria (see Table 2).4,8
Table 1: Medications and Conditions Associated with Chronic Constipation

Medications
5-HT3 receptor antagonists Antiepileptics Antinauseants Antispasmodics

ondansetron gabapentin dimenhydrinate dicyclomine
Anticholinergics phenytoin prochlorperazine Cation-containing
Antidepressants pregabalin promethazine agents
bupropion Antihistamines scopolamine aluminum
mirtazapine diphenhydramine Antiparkinsonian agents barium
monoamine oxidase inhibitors hydroxyzine amantadine bismuth
trazodone Antihypertensives benztropine calcium
tricyclic antidepressants clonidine bromocriptine iron
venlafaxine nifedipine levodopa Diuretics
Antidiarrheal agents verapamil pramipexole NSAIDs
diphenoxylate ropinirole Opioids
loperamide Antipsychotics Resins

cholestyramine
sodium polystyrene
sulfonate
Vinca alkaloids
Conditions
Anatomic obstructions Endocrine/metabolic GI motor disorders Older age

Diverticulosis disorders Hirschsprung's disease Pain
Post surgical abnormalities Chronic renal Irritable bowel syndrome Secondary to anal
failure/uremia fissures, hemorrhoids
Stricture Megarectum and
Cystic fibrosis megacolon Pregnancy
Cancer
Diabetes Pelvic floor dysfunction Psychiatric disorders
Chemotherapy-induced
dehydration Hyper/hypocalcemia Rectoceles Abuse, anxiety, brain
Direct intestinal radiation Hyperparathyroidism Neurogenic disorders injury, depression, eating
Hypokalemia disorders
Hormonal changes Autonomic neuropathy
Hypercalcemia Hypomagnesemia Intestinal pseudo-
Tumor compression of large Hypothyroidism obstruction
intestine Panhypopituitarism Multiple sclerosis
Tumor interference with colonic Porphyria Parkinson's disease
innervations
Dementia Uremia Spinal cord injury
Stroke
Systemic sclerosis
8
Table 2: ROME III Diagnostic Criteria for Chronic Functional Constipation
The following must be present for at least 3 months with an onset of at least 6 months prior to diagnosis:
1. Loose stool rarely present without use of laxatives, and
2. Insufficient criteria to classify as irritable bowel syndrome, and
3. At least 2 of the following criteria:
Straininga
Lumpy or hard stoolsa
Sensation of incomplete evacuationa
Sensation of anorectal obstruction/blockagea
Manual manoeuvres to facilitate defecation (e.g., digital evacuation, support of the pelvic floor)a
Fewer than 3 defecations per week
a Must be present in at least a quarter of the defecations.
If left untreated, chronic constipation may lead to serious complications such as bowel perforation, obstruction, fecal
impaction, peritoneal infection, anal fissures, hemorrhoids, megacolon, pelvic organ prolapse in women and volvulus.9,10,11
Risk factors for chronic or acute constipation include:12,13,14,15
Female gender
Non-white
Living in rural, northern or mountainous areas in North America13
Age over 65 years
Fewer years of formal education
Low caloric intake
Greater number of medications used
Lower socioeconomic status
Physical and sexual abuse
Sedentary lifestyle
Travelling
Toilet training (in children)
Ignoring the urge to defecate (habituates the rectum to the stimulus of the fecal mass).
Goals of Therapy
Treat or correct the secondary cause of constipation
Return frequency of stool to previous normal or at minimum ≥3 defecations per week
Eliminate symptoms of straining, incomplete emptying, bloating, pain and obstruction
Improve stool consistency
Avoid complications of constipation
Use laxatives appropriately
Patient Assessment
Assessment of patients with constipation is necessary to delineate root causes (Figure 2).16,17 The Bristol Stool Scale is a
valuable medical communication aid designed to assist patients in describing bowel patterns in a way that is more useful for
diagnosis and evaluation of treatment (Figure 1).
Diagnostic colon motility tests (e.g., colonic transit studies, colon motility, colonic barostat testing) are usually reserved for
patients with chronic idiopathic constipation who are unresponsive to regular laxative therapy.6,8
Signs and symptoms of constipation include:
infrequent defecation
abdominal distention
nausea
vomiting
anorexia
early satiety
stools that are small, hard and/or difficult to evacuate
incomplete rectal emptying
rectal bleeding due to fissures or hemorrhoids
weight loss (in chronic constipation).
Fecal impaction is the inability to pass a hard collection of stool. Symptoms of impaction include rectal discomfort, anorexia,
nausea, vomiting, abdominal pain, urinary frequency and both fecal and urinary overflow incontinence. Physically or mentally
incapacitated persons and the elderly are at particular risk of impaction, as are those who require long-term use of
medications associated with constipation (Table 1).
In the initial patient assessment, review prescription and nonprescription medications to rule out drug-induced causes (Table
1). This review must also include natural health products since their overuse could cause gut dysfunction and paradoxical
constipation.17
Examine diet, exercise and relevant social or psychological problems. Patients often have self-medicated prior to asking for
assistance. Address the patient's most bothersome symptoms and inquire about past laxative use and failed therapies, to
help maximize adherence and reduce possible side effects.2
Further assessment is required if constipation is accompanied by the following red flags:

children <2 years old
constipation for more than 2 weeks (or no bowel movement for more than 7 days) despite use of laxatives, particularly in
the elderly and in those with chronic medical conditions such as diabetes or Parkinson's disease
blood or mucus in stool or rectal bleeding, fever
symptoms suggestive of anemia such as fatigue or lethargy
family history of colon cancer (particularly if patient is >50 years old)
persistent abdominal pain
vomiting
severe pain upon defecation
unremitting nocturnal symptoms
diarrhea alternating with constipation (could signify irritable bowel syndrome)
recent abdominal surgery
eating disorders such as bulimia nervosa
moderate to extreme thirst
unexplained weight loss of greater than 5%
chronic illness associated with constipation (Table 1)
rectal or abdominal mass.
After a thorough assessment, if the above red flag symptoms are absent and further investigation not required, then
nonpharmacologic and pharmacologic therapy can be recommended for mild-moderate acute cases.
a
Figure 1: Bristol Stool Chart
a
Types 1–2 indicate constipation, types 3–4 represent ideal stool consistencies as they are easier to pass and types 5–7 may indicate
diarrhea and urgency.
Reproduced with permission from Thompson WG, Heaton KW. Fast facts: irritable bowel syndrome. 2nd ed. Oxford (GB): Health Press Limited; 2003.
Prevention
The following strategies may be used to prevent constipation:18
High-fibre diet (should be complemented with a minimum fluid consumption of 1500 mL daily)
Regular, private toilet routine
Heed the urge to defecate
Use of a prophylactic laxative if using constipating medication or in presence of diseases associated with constipation
Moderate daily physical activity may be helpful in mild constipation, particularly in the elderly. Vigorous exercise does not
affect bowel habits in healthy subjects19
Increasing the amount of fluid intake has been controversial unless patient usually drinks very little or is dehydrated.9
Daily fibre intake of at least 25 g for adult females and 38 g for adult males younger than 50 years is currently recommended
for increased laxation and softening of stool.20 Few adults consume this level; 10 g per day of total dietary fibre is often
sufficient as a daily minimum goal. Stool weight increases and fecal transit time usually decreases with adequate fibre
supplementation but pain or stool frequency usually do not improve.9 Soluble fibre (e.g., psyllium) may improve symptoms of
straining and pain and may increase the number of bowel movements in patients with chronic idiopathic constipation. Data
for insoluble fibre (e.g., dark leafy vegetables, rye bread, wheat bran, whole grains) are conflicting.21 Patients with confirmed
slow-transit constipation or pelvic floor dyssynergia respond poorly to a high fibre diet. Table 3 lists the fibre content of some
common foods.
22
Table 3: Dietary Fibre in Selected Raw Foods
Food Source ≥5 g fibre/100 g 2–5 g fibre/100 g <2 g fibre/100 g
Vegetables Artichoke heart Asparagus Celery
Beans, pinto Beets Cucumber
Beans, red kidney Broccoli Iceberg lettuce
Chickpeas Brussels sprouts Mushrooms
Lentils Cabbage Onions
Peas, green Carrots Pepper, green
Cauliflower Radish
Eggplant Rhubarb
Garlic Tomato
Kale Turnip
Parsnips Winter squash
Potato with skin Zucchini
Snow peas
Spinach
Sweet corn
Fruits Avocado Apples with skin Cantaloupe

Blackberries Apricots Grapefruit
Plums Banana Grapes
Prunes Blueberries Honeydew melons
Raspberries Cherries, sweet Mango
Figs Papaya
Kiwi Peaches
Orange, navel Pineapple
Pears Watermelons
Raisins, seedless
Strawberries
Cereals All Bran Captain Crunch Rice Krispies

Bran Buds Corn Flakes
Bran Flakes Special K
Cheerios
Fiber1
Just Right
Life
Mini Wheats
Multigrain Cheerios
Oat Bran
Puffed Wheat
Raisin Bran
Shredded Wheat
Weetabix
Breads Pita bread, whole wheat Bagel, oat bran
Pumpernickel bread Bagel, plain
Rye bread English muffin
Whole-wheat bread Kaiser roll
Muffin, oat bran
Nutrigrain waffle
Pita bread, white
Taco shell
Nuts Almonds
Brazil nuts
Hazelnut
Macadamia
Peanuts
Pistachio
Walnuts
Miscellaneous Popcorn Brown rice

White rice
Wild rice
Adults
Increase calories in low calorie diets: This helps improve colonic transit.9
Have a regular bowel regimen: Patients should attempt to have a bowel movement at the same time each day
especially after breakfast since colonic activity is highest at that time. Encourage patients to heed the urge to
defecate and discourage them from spending prolonged periods of time at the toilet. Placing a footstool in front of
the toilet helps elevate the thighs, thus placing the pelvis in the optimum position for defecation.2,5
Consume a high-fibre diet: The target is 25–38 g of fibre daily or 10–20 g/1000 cal.20,23 Table 3 lists the fibre content
of some common foods. Patients with poor dentition can eat foods that are easy to chew such as bran muffins, bran
cereal, fibre biscuits, applesauce and baked beans. Fibre-enriched formulations of nutritional supplement drinks are
available for those patients unable to prepare meals, or as snacks between meals. Two to 6 tablespoonsful (30–90
mL) of wheat bran daily taken with a 250 mL glass of water or juice can be used to supplement dietary fibre. Gas
production from soluble fibre metabolism may limit acceptance.
Eat more fruits: Apples, pears and prunes contain the natural laxative sorbitol.
Exercise: Because inactivity is associated with constipation, exercise has been advocated as a treatment option.
Though not clearly shown to be effective, it is still worth recommending for many preventive health reasons.
Weight loss: Weight loss is suggested for the treatment of chronic constipation in overweight patients. Like exercise,
benefit has not been proven but is still worth recommending. The goal is to reach a weight compatible with a body
mass index (BMI) of 18.5–24.9 (see Weight Management).
Biofeedback and relaxation: Biofeedback and relaxation training has been used in the treatment of constipation
caused by pelvic floor dysfunction. This trains patients to relax their pelvic floor muscles and to coordinate relaxation
and pushing during defecation.12 Further well-designed trials are necessary to confirm effectiveness.
Children
Aim for a daily dietary fibre level ≥10 g for children 3–7 years old and ≥15 g for children 8–14 years.24
In infants, juices that contain sorbitol (e.g., prune, apple and pear) can increase the frequency of bowel movements
and water content of stools. Barley malt extract (2–10 mL in 250 mL milk or juice) or corn syrup can be used as stool
softeners.25
Children with functional constipation should be encouraged to attempt defecation 5–15 minutes after each meal
until they have a bowel movement that day.3,25,26
Biofeedback may be beneficial for the treatment of a small subgroup of children with intractable constipation.27
For further discussion of pharmacologic therapy for constipation, consult the Compendium of Therapeutic Choices:
Constipation in Adults.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—
Gastrointestinal Products: Colon Electrolyte Lavage, Laxatives.
Constipation should not be managed through medications in the presence of an obstruction or ileus.28
There are 4 basic groups of laxatives: bulk forming, emollient, osmotic and stimulant (see Table 6).29,30,31,32 Other drug
classes include µ-opioid receptor antagonists (e.g., methylnaltrexone, naloxegol), prokinetic agents (e.g., domperidone,
erythromycin, prucalopride) and guanylate cyclase C-agonists (e.g., linaclotide).
Detailed discussions regarding acute and chronic constipation as well as constipation in special populations can be found
under Acute Constipation, Chronic Constipation and Constipation in Special Populations.
Bulk-forming Laxatives
Bulk-forming laxatives increase stool volume and are considered the safest agents suitable for long-term use.8 Their
fermentation in the colon leads to gas formation, increased osmotic load, water retention and wall stress which stimulate
motility.8,33 Each dose of a bulk-forming laxative should be administered with at least 250 mL of water or juice to prevent
fecal impaction and/or esophageal obstruction.8 Do not use if patient is dehydrated or fluid restricted. Psyllium improves
stool frequency and consistency and bran reduces the use of laxatives in the elderly. Although there is insufficient
evidence regarding the efficacy of calcium polycarbophil and methylcellulose in the management of constipation, these
agents are still recommended if patients cannot use or tolerate other bulk-forming laxatives.8,21 Fibre shows consistent
beneficial effect for relieving overall symptoms and bleeding in the treatment of symptomatic hemorrhoids.8
Emollients/Stool Softeners
Stool softeners (e.g., docusate sodium or docusate calcium) act as surfactants to soften the stool by allowing the mixing
of aqueous and fatty substances.10 Although stool softeners have minimal if any effect on improving symptoms of
chronic constipation and supporting evidence for their effectiveness is lacking, these agents may be useful for some
patients who cannot tolerate more potent laxatives or when constipation is mild.34
Heavy mineral oil is not generally recommended due to risk of lipid aspiration and binding of fat-soluble medications.
Studies in pediatric patients have shown it is superior to senna-based laxatives for frequency and stool consistency and
inferior to osmotic agents which have fewer risks.3,25,35
Osmotic Laxatives
This class contains poorly absorbed ions or molecules that create an osmotic gradient and retain water within the
intestinal lumen; the increased pressure on the lumen wall induces gastric motility.7,36,37 Polyethylene glycol (PEG) and
lactulose are examples of osmotic laxatives.7,36,37
PEG is a safe, effective and well-tolerated agent and causes less flatulence and bloating in adults compared with other
osmotic laxatives.38 PEG is superior to lactulose in outcomes of stool frequency per week, stool form and consistency,
relief of abdominal pain and need for additional products.39,40 PEG is considered more palatable than lactulose. Daily use
of PEG (up to 6 months) is safe and effective41 and may facilitate the discontinuation of other laxatives. As many as 40%
of patients, however, could experience diarrhea with PEG or lactulose. Lower doses help prevent bloating, cramping,
flatulence and electrolyte abnormalities. PEG may also be effective in the management of opioid-induced constipation.42
Glycerin suppositories act osmotically and have a quicker onset of action (approximately 15–30 minutes). They are less
effective if the stool is dry and hard. Glycerin suppositories should be moistened with lukewarm water before insertion and
retained as long as possible.
There is some evidence that milk of magnesia can be used for chronic constipation in patients with normal renal
function.43 Limitations include frequent diarrhea, multiple electrolyte abnormalities (e.g., hypermagnesemia,
hyperphosphatemia, hypercalcemia, hyponatremia, hypokalemia) and hypovolemia.44 These side effects may occur even
in the absence of pre-existing renal failure. They should be administered with sufficient water to prevent dehydration.43
Oral sodium phosphate products should not be used as purgatives since they may cause serious electrolyte, kidney,
cardiovascular and neurologic problems, but they are still considered safe and effective for laxative use. Magnesium
citrate is generally reserved for bowel cleansing.
Osmotic laxatives alone or in combination with stimulants are most commonly used as cathartics before surgery or
intestinal procedures.
Stimulant Laxatives
This group of laxatives (e.g., bisacodyl, senna, sodium picosulfate) increase colonic peristalsis by producing rhythmic
muscle contractions in the intestines and may be recommended if osmotic laxatives fail or are not tolerated.43,45 All 3
medications are prodrugs. Senna is activated in the large bowel whereas bisacodyl and sodium picosulfate are activated
in the alkaline medium of the small intestine.46 Limiting their use helps minimize melanosis coli, abdominal discomfort,
electrolyte imbalances, allergic reactions and hepatotoxicity.
Stimulant laxatives are likely safe in the treatment of chronic constipation.43 Some evidence supports the short-term (4
weeks) efficacy and safety of bisacodyl47 and sodium picosulfate48 in chronic constipation.49 Continuous daily usage
may cause hyponatremia, hypokalemia and dehydration. Stimulant laxatives are usually administered at bedtime due to 6–
12 hour delay in onset and are the laxatives of choice for opioid-induced constipation.
Castor oil use as a laxative is no longer recommended and is contraindicated in pregnancy and the elderly. It produces
abdominal cramping and pain and stimulates uterine contractions during pregnancy and can be aspirated by the elderly.
Enemas
There is only anecdotal evidence for the value of enemas in the management of chronic constipation. However, many
clinicians and patients find them useful and effective for the treatment of acute constipation and as a means of preparing
or cleansing the distal colon for endoscopic or surgical procedures. Enemas generally have faster onset than
suppositories and produce cleansing within an hour of administration. They are, however, less “socially” accepted by North
Americans for chronic constipation and are mainly used for bowel cleansing prior to intestinal procedures. Caution is
warranted when using enemas in the elderly since they are associated with increased mortality.50
Instructions for Administering an Enema
The patient should:
Lubricate the enema nozzle if it is not pre-lubricated

Lie on left side with knees bent
Insert the enema nozzle into the rectum, with the nozzle pointing towards the navel
Gently squeeze the container until the dose is expelled; if discomfort is felt at this point, the flow is probably too fast
Retain the solution until definite abdominal cramping is felt.
Probiotics
Evidence is insufficient to support the use of probiotics in the treatment of chronic idiopathic constipation. There has been
no direct comparison of different probiotic regimens in the management of constipation and the most beneficial strains,
doses, dosing frequency and duration remain unclear.51,52,53
Only a few small randomized controlled trials and little other evidence supports the efficacy and/or safety of the following
herbal treatments: aloes, bitter orange, buckthorn, dandelion, elderberry, hemp seed, lavender, licorice, rhubarb and soy.
Yellow dock is an effective laxative but its safety has not been definitively established.54,55
Homeopathic Therapy
No clinical trials could be found investigating the use of homeopathy in constipation. Some commonly used remedies
include alumina, bryonia, calcarea carbonica, conium, lycopodium, natrum muriaticum, nux vomica, sepia and silicea.54,55
Long-term Use of Laxatives
Most patients suffering from constipation will self-medicate. They may overuse laxatives and anti-diarrheals resulting in a
pendulum effect between constipation and diarrhea. This type of abuse is present in about 4% of laxative users.2 Long-
term use of stimulant laxatives has traditionally been discouraged based on tests linking long-term use to damage of the
enteric nervous system in the mesenteric plexus and smooth muscles of the colon. However, the results of these tests
have not been confirmed by newer technologic methods. Many experts now believe that the risks of long-term stimulant
laxative use have been overemphasized, and that they are safe for daily use.56 However, due to the increased cost and side
effects such as cramping, reserve stimulants for third-line therapy when previous treatment has failed.
Melanosis coli is a melanotic hyperpigmentation of the colonic mucosa that occurs after long-term use of the
anthraquinones. It is benign and reverses 3–12 months after discontinuation of the laxative.16
Other side effects of laxative overuse include various electrolyte abnormalities; hypermagnesemia, hypernatremia and
hyperphosphatemia can occur due to accumulation of absorbed ions derived from the laxative.44 Hypernatremia can also
arise when large volumes of osmotic laxatives cause substantial water loss from the GI tract. Hypokalemia may result as
the body tries to regain fluid losses by activating the renin-aldosterone system.6
Acute Constipation
Acute and chronic constipation require different management. Acute constipation is a term without a clear definition and
its optimal management has not been well studied. Prevalence of acute constipation is not known, as the definition varies;
however, it is more common than chronic constipation as defined by the ROME III criteria.8
Therapy is often based on the patient's level of discomfort. In general, it is best to clear out hard stool in the distal bowel
before using a bulk agent or an aggressive oral regimen.57 A reasonable approach is to use an agent with a relatively quick
onset of action, e.g., glycerin or bisacodyl suppositories.5 As well, saline laxatives are used to treat acute constipation if
there is no indication of bowel obstruction, heart failure or renal impairment.5
If constipation is not relieved within 48 hours, add an agent with a quicker onset of action such as an enema. If fecal
impaction is present, it must be relieved before maintenance treatment can begin. Disimpaction may be initiated manually,
and then a tap water, phosphate, saline or mineral oil enema (with or without a local anesthetic lubricant) can be inserted
daily for up to 3 days. Avoid soapsuds enemas because of an irritant effect on the colonic mucosa that may result in
proctitis or colitis.16 If the stool blockage is higher up in the colon than can be reached with enemas and the patient has
no sign of bowel obstruction, use polyethylene glycol orally to disimpact the patient (2 litres for 1–2 days or 1 litre for 3
days).58 Patients should not self-disimpact unless trained to do so. Avoid bulk-forming laxatives if impacted.
Chronic Constipation
Chronic constipation may cause atonic bowels and dependency on laxatives to stimulate motility. Slowly weaning the
patient from a stimulant laxative to an osmotic laxative may improve long-term control particularly if the patient
experiences permanent loss of smooth muscle contractility. Stimulant laxatives may be necessary in patients with slow
motility secondary to diabetes or use of opioid medications. In most cases, the laxative should be tapered down to the
lowest effective dose in order to minimize side effects.
Chronic constipation is treated in a stepwise approach (Table 4).59
Table 4: Management of Chronic Constipation

Step I Unless a modifiable cause is identified, chronic constipation is initially managed by patient
education, lifestyle modification and dietary changes, including fibre supplementation (bran)
and/or bulk-forming laxatives. Fibre intake should be increased gradually every 7–10 days.
Saline laxatives, glycerin suppository and/or enemas may be used as rescue treatment if no
bowel movement has occurred for 2 consecutive days.
Step II After a 4- to 6-wk trial, if the problem persists, second-line agents such as an osmotic or
saline laxative may be added.
Step III Third-line agents such as emollients and stimulants should be limited to short-term use after
other agents have failed. This is due to the high incidence of side effects from these classes.
Constipation in Special Populations
Pediatrics
The overwhelming majority of children with chronic constipation suffer from functional constipation, involving a cycle
of pain on defecation, fecal retention and chronic rectal distention.25 Chronic constipation is estimated to occur in 1–
5% of children. A third of these children have chronic constipation beyond puberty.25 Management of constipation
specific to the treatment of infants and children is presented below.
Infants
The use of enemas is not recommended in infants.3,25,35

Rectal disimpaction of infants can be achieved with pediatric glycerin suppositories.3
Barley malt extract, corn syrup, lactulose or sorbitol can be used as stool softeners.25
Heavy mineral oil and stimulant laxatives are not recommended for infants.35
Constipation may be linked to milk intolerance in some children. A time limited trial of a cow's milk–free diet
may be useful to rule out this as a cause.
Children ≥1 Year
Increased consumption of dietary fibre may improve stool frequency and consistency in children with constipation
but does not reduce the need of laxatives.60 Aim for a daily dietary fibre intake ≥10 g for children 3–7 years and ≥15
g for children 8–14 years.24 There are no trials assessing the effectiveness of bulk-forming laxatives (e.g., psyllium)
in children. PEG,61 lactulose or sorbitol are considered first-line agents for the treatment of constipation whereas
magnesium hydroxide and heavy mineral oil are second-line.25,26 PEG may be superior to lactulose and
magnesium hydroxide in this population.61 Side effects include flatulence, abdominal pain, nausea, diarrhea and
headache. Of the different polyethylene glycols, the PEG 3350 is better tolerated and accepted by children than the
PEG with electrolytes.62 Young children are at increased risk of lipoid pneumonia due to aspiration of mineral oil.26
No evidence supports the use of stool softeners. Senna and bisacodyl can be used as rescue medication when
other agents have failed.25
Disimpaction with enemas is recommended after diagnosis of impaction via rectal examination or, in some cases,
abdominal radiography; higher doses of oral PEG 3350 1–1.5 g/kg/day may also be effective but may take up to 5
days of treatment.36 Biofeedback therapy can be an effective short-term treatment of intractable constipation.27
Constipation affects up to 25–30% of women in late pregnancy and up to 3 months postpartum.63,64 It is thought to be
secondary to elevated progesterone levels causing muscle relaxation in the intestine. It may also be due to the use of
calcium and iron supplements and the gravid uterus pushing on the colon.65 Dietary bran or wheat fibre is preferred as
initial treatment of constipation during pregnancy to increase the frequency of defecation and soften stools.66
Docusate has traditionally been added if fibre supplementation has failed during pregnancy but there is little evidence
to support this practice. Heavy mineral oil is not absorbed systemically but may impede vitamin or mineral absorption.
If stools remain hard, consider adding or switching to lactulose or PEG. Stimulant laxatives are more effective than
dietary or medicinal fibre therapy but cause more side effects of diarrhea and abdominal pain; they are reserved for
short-term use when other agents have failed.66 Use stimulant and osmotic laxatives short term to prevent possible
dehydration and electrolyte disturbances.67 Occasional use of glycerin or bisacodyl suppositories is also an option.
One study found no association between senna and higher risk of congenital abnormalities in pregnant women.68
Elderly
Treatment of the older adult is often complicated by comorbidities, cognitive impairment and polypharmacy.59 There is
a paucity of evidence-based recommendations in the management of constipation in the elderly.69 Management
should be tailored to each individual's needs and expectations regardless of age or place of residence.
Functional abilities related to mobility, following instructions, communicating needs, eating, drinking and cognitive
status must be assessed.14
Fluid intake should target 1500–2000 mL daily unless fluid restrictions are imposed as in those with heart failure. Low
fluid consumption with bulk forming laxatives can exacerbate constipation. Dietary fibre should be targeted at 25–30 g
daily which may allow discontinuation of laxatives and may increase the senior's well-being.69 Exercise may be
performed to patient's capacity; pelvic tilt, trunk rotation and leg lifts are recommended for bedridden patients.70
Medication review should rule out polypharmacy and drug-induced constipation.18
Renal impairment must be determined prior to using laxatives. The use of saline laxatives is contraindicated in renal
and heart failure. Limitations for use include possible multiple electrolyte abnormalities such as hypermagnesemia,
hyperphosphatemia, hypocalcemia and hypokalemia.71 When used, oral saline laxatives (e.g., sodium phosphate)
should be administered with sufficient water to prevent dehydration. Magnesium citrate is generally reserved for bowel
cleansing and should be used with caution in renal impairment. PEG is safe and effective for use in seniors suffering
from acute or chronic constipation.41 Stimulant laxatives (e.g., senna, bisacodyl) may cause severe cramping and
electrolyte losses when used long term.
Encourage institutions to establish an interdisciplinary team approach to prevent and manage constipation.18
Palliative Care and Cancer Patients
Constipation is prevalent in 50% of cancer patients and rises to 78% in the palliative patient due to the use of high-dose
opioids.45 Decreased GI motility, tumour compression of the large intestine or interference with colonic neural
innervation is the usual mechanism involved (Table 1).72
The best therapy to manage constipation in this population is uncertain. Traditionally, stimulant laxatives have been
the mainstay of therapy with rescue enemas or bisacodyl suppositories used when required for a period not exceeding
3 days. Higher doses of stimulant laxatives may be necessary in palliative patients (e.g., senna 34.4 mg TID, bisacodyl
20 mg TID or sodium picosulfate 30 mg at bedtime). Laxative dose may be increased every 24–48 hours until response
or a ceiling dose is reached. It is best to maximize doses of stimulant laxative prior to adding an osmotic agent.
Lactulose and PEG are alternatives but may cause nausea.37 Impaction should be ruled out if the patient has not
passed a stool in more than 3 days.45
There is significant evidence supporting the use of µ-opioid receptor antagonists (e.g., methylnaltrexone, naloxegol) in
treatment of opioid-induced constipation. These agents are considered second-line if traditional laxatives fail.
Avoid bulk-forming agents since they may cause impaction.45 Stool softeners are unlikely to have any benefit in this
population. In neutropenic or thrombocytopenic patients, avoid rectal manipulation to prevent infection or bleeding;
give oral laxatives and cathartics only.
The use of a daily bowel log may be helpful in patients with chronic constipation, including children. A sample log is included
in Constipation—What You Need to Know.
Table 5: Monitoring of Therapy for Constipation

Inability to have bowel Acute constipation: Full bowel movement. Add agent with a relatively
movement Patient: Daily quick onset of action (e.g.,
glycerin suppository). If
Healthcare practitioner: other laxative not effective,
After 1–3 days of therapy, or if patient has not had a
depending upon the agent bowel movement in 7 days,
chosen reassess.
Chronic constipation: As Chronic constipation: As Chronic constipation: If

above plus: above, plus patient should patient has not established
Patient: Keep daily bowel have established regular regular patterns after 1
log (see Daily Bowel Log bowel patterns after 1 month, reassess treatment
sample table below) month. plan.
Healthcare practitioner:
Check with patient weekly
for 4 wk
Bloating, cramping Acute constipation: Bloating and cramping If full bowel movement has
Patient: Daily should be relieved shortly occurred but bloating and
after full bowel movement cramping are not relieved,
Healthcare practitioner: Day occurs. reassess.
3

All patients should receive advice regarding:
Normal variation in frequency of bowel movements

Nonpharmacologic methods of treating and preventing constipation
Development of an individualized bowel routine
Evaluation of the signs and symptoms and when they should contact a healthcare practitioner.
In addition, all patients who require drug therapy should receive counselling regarding:
The expected onset of action of the laxative and what to do if constipation is not relieved (long-term constipation may
require weeks to months of therapy for bowel habits to adjust)
Usual side effects of the medication.
Algorithms
Figure 2: Assessment and Treatment of Patients with Constipation

Drug Table
Table 6: Pharmacologic Treatment and Prevention of Constipation
Interactions
Bulk- bran >12 y: 1–7 Diarrhea, bloating, May interfere Reduces total $
forming g/dose daily to flatulence. with cholesterol and
Agents BID po; absorption of risk of colon
maximum 14 iron, calcium cancer. Can be
g/day and fat-soluble added to yogurt,
6–12 y: 1–3.5 vitamins. cereals, soups or
g/dose daily to applesauce. If
BID po; patient has
maximum 7 celiac disease
g/day use rice bran.
Onset: 3–5 days

Interactions
Bulk- polycarbophil >12 y: 1 g daily to Generally well- If possible, do $

forming calcium QID po; tolerated, some not take within
Agents Prodiem maximum 4 flatulence, bloating. 2 h of other
Tablets g/day Other adverse medication or
6–12 y: 0.5 g reactions reported the effect of
daily to QID po; include esophageal the other
maximum 2 obstruction and medication
g/day fecal impaction. may be
reduced.
2–5 y: 0.5 g daily
to BID po;
maximum 1
g/day
Onset: 12–72 h
Bulk- psyllium >12 y: 2.5–7.5 Generally well If possible, do Contraindicated $

forming Metamucil g/dose daily to tolerated; some not take within if partial
Agents Preparations, TID po with 250 flatulence, bloating 2 h of other mechanical
generics mL of water or common at start of medication or obstruction of GI
juice; maximum therapy. This can be the effect of tract.
30 g/day minimized by the other Inappropriate for
6–12 y: 2.5–3.75 starting with a low medication fluid-restricted
g/dose dose and gradually may be patients or
1–3 times daily increasing. reduced. May patients with
po with 250 mL Anaphylaxis, cause calcium dysphagia,
of water or juice; asthma and other and iron esophageal
maximum 15 allergic reactions malabsorption. strictures or
g/day have been reported. partial
Allergic reactions obstructions of
<6 y: Safety and may occur in up to GI tract.
efficacy not 18% of healthcare Administration
established workers with of adequate
Onset: 12–72 h occupational amount of fluid
exposure to with each dose
psyllium. is important to
Esophageal prevent
obstruction and esophageal
fecal impaction obstruction
have been reported. and/or fecal
impaction. When
used to treat
chronic
functional
constipation
may take 2–3
months for
maximum
effect. Psyllium
powder and
capsules are
gluten-free.
Enemas mineral oil >12 y: 120 mL as Incontinence. Risk No known drug Softens and $$$
retention a single dose pr of mechanical interactions. lubricates stool.
enema 2–12 y: 60 mL as trauma to rectal
Fleet Enema a single dose pr wall.
Mineral Oil
<2 y: Not
recommended
Onset: 5–15 min
Interactions
Enemas phosphate >12 y: 120 mL as Abdominal No known drug Avoid in patients $$

enema a single dose pr distension, interactions. with potential for
Fleet Enema, 2–12 y: 60 mL as vomiting. prolonged
generics a single dose pr Hyperphosphatemia retention (e.g.,
Under a and hypocalcemia paralytic ileus,
physician's have occurred; congenital
supervision most common in megacolon) and
doses of 6 patients with renal those with
mL/kg (up to 135 dysfunction or cardiac disease,
mL) have been when enema is renal
used retained too long. dysfunction or
pre-existing
<2 y: Avoid electrolyte
Onset: 5–15 min abnormalities.
Risk of
mechanical
trauma to rectal
wall.
Enemas tap water Adults: 500 mL Water intoxication No known drug Evacuation $
enema pr and dilutional interactions. induced by
<2 y: Not hyponatremia have distended colon;
recommended occurred in children, mechanical
the elderly and lavage. May be
Onset: 5–15 min patients with uncomfortable
megacolon. Risk of for patient.
mechanical trauma Use warm, but
to rectal wall. not hot, tap
water.
Interactions
Lubricants mineral oil >12 y: 15–45 mL Lipoid pneumonia if May reduce Not generally $
(heavy) HS po while aspirated. absorption of recommended.
Lansoyl, sitting up Theoretical vitamins A, D, E Lubricates
others 6–12 y: 5–15 mL interference with and K. May contents of GI
HS po while fat-soluble drug and increase tract for the
sitting up vitamin absorption. anticoagulant relief of
Foreign body effect due to occasional
1–5 y: 1–3 reaction, decreased constipation.
mL/kg HS po dehydration. absorption of Can be mixed
while sitting up; Seepage from vitamin K. Do with fruit juice or
maximum 15 mL rectum may cause not use with carbonated
HS perianal pruritus. docusate, beverage. Not
<1 y: Not which recommended
recommended increases for periods >1
absorption of wk. Light
Onset: 6–8 h
mineral oil. mineral oil
should not be
used internally.
Young children
and elderly may
be at higher risk
of aspiration.
Due to
aspiration risk,
not
recommended
for those who
are bedridden or
have swallowing
difficulties,
gastric retention
or GERD.
Crosses
placenta.
Has caused
hemorrhagic
disease of the
newborn; not
recommended
for prolonged
periods in
pregnancy.
Minimally
absorbed but
not metabolized;
accumulates in
tissues with
repeated use.
Interactions
Osmotic glycerin Adults: 2.6 g Rectal irritation. No known drug May dissolve in $
Agents Glycerin suppository pr interactions. hands if not
Suppositories, daily or BID PRN. inserted soon
generics Insert high into after
rectum and unwrapping.
retain for 15 min
if possible
Children: 1.44 g
suppository pr
daily or BID PRN.
Insert high into
rectum and
retain for 15 min
if possible
Onset: 15–30
min
Osmotic lactulose >12 y: 15–30 mL Flatulence and Slower Many patients $

Agents generics daily or BID po abdominal cramps absorption of find sweet taste
6–12 y: 10 mL are common, medication intolerable.
BID po especially at the from the Avoid in patients
beginning of intestine due who require a
1–5 y: 5 mL BID therapy. Nausea is to galactose-free
po more common with acidification. diet. 667 mg
Onset: 24–48 h higher doses. Ideally, do not lactulose = 147
Diarrhea is a sign of take within 2 h mg galactose,
overdosage. of other <80 mg lactose.
medication. Not absorbed
systemically.
Can be used by
patients with
diabetes.
Osmotic magnesium Adults: 75–150 Risk of May reduce Caution with $$$
Agents citrate mL once daily po hypermagnesemia bioavailability dehydration. Not
Citro-Mag, as laxative. 300 increased with of digoxin and recommended
generics mL once po as overdose, in infants the with cardiac or
cathartic and those with renal tetracyclines. renal disease.
Drink 250 mL impairment. Chill solution
water before and before
after each dose administration
for greater
Children palatability.
(maintenance): Often used as a
>12 y: 150–300 cathartic prior to
mL once daily po surgery or GI
procedures.
6–12 y: 50–100
mL once daily po
<6 y: 1–3 mL/kg
once daily po
Do not exceed
adult dose
Onset: 0.5–3 h
Interactions
Osmotic magnesium Adults: 15–30 Risk of No known drug Caution with $

Agents hydroxide mL daily or BID hypermagnesemia interactions. dehydration. Not
Milk of po increased with recommended
Magnesia, Children: 80–240 overdose and in with cardiac or
generics mg/kg daily po infants and those renal disease.
with renal
Do not exceed impairment.
adult dose Hypokalemia may
Onset: 0.5–3 h also occur with
prolonged use or
overdose.
Dehydration,
abdominal cramps,
incontinence.
Osmotic polyethylene Adults: 17 g (1 Transient diarrhea, Slower Available with or $

Agents glycol heaping flatulence, nausea, absorption of without
Lax-A-Day, tablespoonful) in retching, abdominal medication electrolytes
Pegalax, 250 mL of liquid bloating, cramping, from the (both
RestoraLAX once daily po anal irritation. intestine due formulations are
Children 2–18 y: Pulmonary edema to equally effective
0.4–0.8 g/kg/day may occur if acidification. in the treatment
po in 240 mL powder is aspirated. Ideally, do not of constipation).
liquid (not to Mallory-Weiss tears take within 2 h Causes retention
exceed adult have occurred. of other of water in GI
dose) medication. lumen. Not
fermented into
Onset: 48–96 h hydrogen or
methane by the
GI microbiota
and has no
effect on the
absorption or
secretion of
glucose or
electrolytes. Do
not use if bowel
obstruction.
Space 2 h from
other
medication.
Avoid high
doses in the
elderly due to
increased risk of
diarrhea.
Interactions
Osmotic sodium All doses of Hypocalcemia, ACE inhibitors, Considered to be $$$

Agents phosphate concentrated hypokalemia and angiotensin safe as laxative
generics solution are hypernatremia have receptor but unsafe if
diluted in 125 mL also been reported. blockers, used as
water and Caution with renal diuretics and purgative due to
followed by 250 or cardiac disease. NSAIDs may association with
mL water enhance the electrolyte
≥13 y: nephrotoxic disturbances
effect of and kidney
20 mL of sodium injury. Best taken
concentrated phosphate. on an empty
solution (with stomach upon
water as above) rising, 30 min
once daily po before a meal, or
10–12 y: 10 mL at bedtime. Not
of concentrated recommended
solution (with for pregnant or
water as above) nursing women.
once daily po Not
recommended
6–9 y: 5 mL of
for sodium-
concentrated
restricted
solution (with
patients or for
water as above)
chronic use.
once daily po
Onset: 0.5–3 h
Each 5 mL of
concentrated
solution contains
2.4 g monobasic
sodium
phosphate
monohydrate
and 0.9 g dibasic
sodium
phosphate
heptahydrate
Osmotic sorbitol 70% Adults: 15–30 Flatulence, No known drug Cost-effective $

Agents solution mL daily or BID abdominal cramps, interactions. alternative to
po nausea, diarrhea. lactulose.
Rectal enema Caution in
120 mL pr as severe
25–30% solution cardiopulmonary
or renal
Children: 1–3 impairment.
mL/kg in divided
doses po (not to
exceed adult
dose)
Rectal enema
30–60 mL pr as
25–50% solution
Onset:
po: 24–48 h
pr: 5–15 min
Interactions
Stimulants bisacodyl >12 y: 5–10 mg Abdominal pain, Should not be Appears in $

Dulcolax, HS po or 10 mg cramps, diarrhea, taken with breast milk.
Carters Little suppository pr hypokalemia. milk, antacids Tablets should
Pills, generics 6–12 y: 5 mg HS Incontinence. or proton not be crushed,
po or 5 mg Rectal pump broken or
suppository pr administration may inhibitors chewed.
cause rectal because these
Onset: irritation or burning. products
po: 6–12 h increase the
pH of the
pr: 0.5–1 h
upper GI tract
causing the
premature
disintegration
of the enteric
coating in the
stomach
before the
product
reaches the
colon.
Stimulants cascara Adults: 2–5 mL Abdominal No known drug Avoid in $

sagrada or 0.3–1 g HS po discomfort, interactions. pregnancy.
Not for use in diarrhea, Aromatic
children hypokalemia, formulation
allergic reactions. contains 0.2%
Onset: 6–12 h alcohol.
Excreted into
breast milk. May
discolour urine
red to pink or
brown to black.
Stimulants senna >12 y: 10–15 mL Abdominal pain, No known drug Excreted into $
Senokot (1.7 mg/mL) or diarrhea, interactions. breast milk. May
Preparations, 2–4 tablets (8.6 hypokalemia, discolour urine
others mg/tablet) HS dehydration, allergic red to pink or
po; maximum 15 reactions and, brown to black.
mL or 4 tablets rarely, proctitis and Not first-line in
BID po idiosyncratic pregnancy.
Pregnancy and hepatitis, melanosis
children 6–12 y: coli.
5–10 mL or 1–2
tablets HS po;
maximum 10 mL
or 2 tablets BID
po
2–5 y: 3–5 mL
once daily po;
maximum 5 mL
BID po
Onset: 6–12 h
Stool docusate Adults: 240 mg Usually well Absorption of Evidence weak $

Softeners calcium daily or BID po tolerated. Mild, mineral oil may regarding
generics Onset: 12–72 h transient nausea or be increased. efficacy of stool
GI cramps may softeners.
occur. Occasional
rash.
Interactions
Stool docusate >12 y: 100 mg Usually well Absorption of Available as $

Softeners sodium BID po tolerated. Mild, mineral oil may capsules or
generics 6–12 y: 40–150 transient nausea or be increased. liquid.
mg once daily or GI cramps may
divided BID po occur. Occasional
rash.
3–5 y: 20–60 mg
once daily or
divided BID po
<3 y: 10–40 mg
once daily or
divided BID po
Onset: 12–72 h
a Cost per day; includes drug cost only.

Legend: $ <$1 $$ $1–3 $$$ $3–6
Suggested Readings
American Gastroenterological Association, Bharucha AE, Dorn SD et al. American Gastroenterological Association medical
position statement on constipation. Gastroenterology 2013;144:211-7.
Basilisco G, Coletta M. Chronic constipation: a critical review. Dig Liver Dis 2013;45:886-93.
Gandell D, Straus SE, Bundookwala M et al. Treatment of constipation in older people. CMAJ 2013;185:663-70.
Paré P, Fedorak RN. Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation.
Can J Gastroenterol Hepatol 2014;28:549-57.
Shah BJ, Rughwani N, Rose S. In the clinic. Constipation. Ann Intern Med 2015;162:ITC1.
References
1. American Gastroenterological Association, Bharucha AE, Dorn SD et al. American Gastroenterological Association
medical position statement on constipation. Gastroenterology 2013;144:211-7.
2. Bharucha AE, Pemberton JH, Locke GR. American Gastroenterological Association technical review on constipation.
Gastroenterology 2013;144:218-38.
3. Levy J, Volpert D. Know thy laxatives: a parent's guide to the successful management of chronic functional
constipation in infants and children. Digestive Health Matters Summer 2004.
4. Chang JY, Locke GR McNally MA et al. Impact of functional gastrointestinal disorders on survival in the community.
Am J Gastroenterol 2010;105:822-32.
5. Wong PW, Kadakia S. How to deal with chronic constipation. A stepwise method of establishing and treating the
source of the problem. Postgrad Med 1999;106:199-200, 203-4, 207-10.
6. Medscape. Constipation. Available from: www.emedicine.medscape.com/article/184704-overview. Registration
required.
7. Johanson JF. Review of the treatment options for chronic constipation. MedGenMed 2007:9:25.
8. Longstreth GF, Thompson WG, Chey WD et al. Functional bowel disorders. Gastroenterology 2006;130:1480-91.
9. Thompson WG. Constipation: a physiological approach. Can J Gastroenterol 2000;14:155D-162D.
10. Borum ML. Constipation: evaluation and management. Prim Care 2001;28:577-90.
11. Leung L, Riutta T, Kotecha J et al. Chronic constipation: an evidence-based review. J Am Board Fam Med 2011;24:436-
51.
12. Locke GR, Pemberton JH, Phillips SF. American Gastroenterological Association medical position statement:
guidelines on constipation. Gastroenterology 2000;119:1761-6.
13. Higgins PD, Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol
2004;99:750-9.
14. Towers AL, Burgio KL, Locher JL et al. Constipation in the elderly: influence of dietary, psychological and physiological
factors. J Am Geriatr Soc 1994;42:701-6.
Diarrhea
Antonietta Forrester, BScPhm

Introduction
Diarrhea is the unusually frequent excretion of watery stools. It is associated with loss of electrolytes and loss of fecal
matter at a rate of >200 g/24 hours.1 A more practical working definition is ≥3 loose or watery stools per day or a
definite decrease in consistency and increase in frequency based on an individual baseline.2 Decreased fluid
absorption or increased fluid secretion can lead to dehydration, which can ultimately lead to death, particularly in
children and the elderly. This chapter has 2 parts, (1) Acute and Chronic Diarrhea and (2) Travellers' Diarrhea which
could have an acute or chronic course.
Acute and Chronic Diarrhea
Introduction
Although temporal definitions vary, diarrhea can be classified as acute (<14 days in duration) or chronic (>14 days in
duration or repeated episodes of diarrhea lasting <14 days each).
Diarrhea is believed to be underreported.3 The incidence of acute diarrhea in industrialized countries is approximately
0.5–2 episodes per person yearly and considerably higher in developing and underdeveloped countries.4 In older
children, adolescents and adults, diarrhea accounts for about 2.8 billion episodes annually worldwide.5 Diarrhea is
common in the pediatric population; statistics indicate that children <5 years experience 1.3–2.7 episodes of diarrhea
yearly.6 Eighteen percent of all deaths in children under the age of 5 years are attributed to diarrhea and 78% of those
deaths occur in African and South East Asian regions. In this age group, diarrhea is the second leading cause of death
following pneumonia.7 As a result, the integrated Global Action Plan for the Prevention and Control of Pneumonia and
Diarrhea hopes to reduce death from diarrhea in children under 5 years to <1 in 1000 by 2025.8
Aside from dehydration, complications of diarrhea include electrolyte imbalances, hypotension, vascular collapse,
metabolic acidosis, hypokalemia, hypomagnesemia, hemorrhoids and rectal prolapse. Diarrhea often results in a
decreased ability to perform daily activities.
Pathophysiology
Chronic diarrhea is often indicative of a functional bowel disorder such as irritable bowel syndrome. Intestinal diseases
with underlying inflammation (e.g., inflammatory bowel disease) are also prevalent. Food intolerances and sensitivities,
ischemic colitis, microscopic colitis, GI infections, radiation or chemotherapy and maldigestion or malabsorption of fat
or carbohydrates (celiac disease, lactose intolerance) can also be responsible for chronic diarrhea. Foods that contain
large amounts of sorbitol or mannitol can cause osmotic diarrhea.9
The most common causes of acute diarrhea are bacterial and viral infections and food toxins. Acute childhood
diarrheal pathogens are transmitted by close contact and in particular the oral-fecal route. Childcare settings are a
common place for acquiring infectious diarrhea. Infectious viral agents include:9
Rotavirus—responsible for causing severe diarrhea in infants and children, and the most common cause of
gastroenteritis among children worldwide.10
Norwalk-like virus—responsible for a milder form of diarrhea affecting older children and adults
Adenovirus
Calicivirus
Drugs are also a common cause of diarrhea (Table 1). In particular, broad-spectrum antibiotics such as penicillins,
cephalosporins and erythromycins are implicated in altering the bacterial flora of the gut, resulting in diarrhea. This
usually occurs 2–3 days after starting the antibiotic and resolves when the antibiotic is discontinued. An uncommon
but potentially serious result of antibiotics use is Clostridium difficile-associated diarrhea. The agents most often
implicated as causes of C. difficile-associated diarrhea are clindamycin, ampicillin and the cephalosporins,13 although
any antimicrobial agent can cause it, including those used to treat it. The condition can occur in anyone who has
received an antibiotic within the previous 3 months and is characterized by significant loss of fluid, fever and abdominal
pain.
1,11,12
Table 1: Drugs Associated with Diarrhea
Acetylcholinesterase inhibitors Cholinergics Orlistat
Alcohol Dopamine antagonists Potassium supplements
Antacids—magnesium salts Histamine H2-receptor antagonists Prostaglandins
Antibiotics HIV medications Proton pump inhibitors
Anticoagulants Immunosuppressants Quinidine
Antidiabetics Lactose-containing pharmaceuticals (in SSRIs
Antihypertensives lactose intolerant patients) Sulfasalazine
Antimetabolites Laxatives Theophylline
Cardiovascular drugs Lithium Ticlopidine
Chemotherapeutic agents NSAIDs
Other causes of diarrhea include: nervousness or anxiety, gastrointestinal or pancreatic tumors, diabetes mellitus,
opiate withdrawal, rapid increase of fibre in the diet, enteral nutritional supplements, deficiencies of specific nutrients
such as vitamin A and zinc,14 excesses of specific nutrients such as vitamin C and magnesium,1,9 certain metals,
organic toxins and plant products (e.g., arsenic, insecticides, mushroom toxins, caffeine).15
Goals of Therapy
Determine the specific etiology where possible and treat appropriately
Decrease the symptoms and re-establish normal stools
Avoid and treat complications such as dehydration
Identify red flags (see Table 2) and cases requiring further diagnostic testing
Patient Assessment
For those with noninfectious diarrhea, conducting a thorough patient history may be helpful in elucidating the
underlying cause. This can include travel and animal exposure history, sources of water (e.g., well water), recent food
consumption, history of past diarrheal episodes and recent antibiotic use.
Aside from frequent loose stools, symptoms of infectious diarrhea may include nausea, vomiting, abdominal pain,
headache, fever, chills and malaise. Presence of “red flags” (Table 2) requires further detailed patient assessment.
Table 3 presents symptoms of dehydration in children and adults. Figure 1 depicts decreased skin turgor.
Question patients with repeated episodes of diarrhea about any relationship between symptoms and consumption of
dairy or grain products to rule out lactose or gluten intolerance (see Special Diets).
Table 2: Red Flags Associated with Diarrhea

Blood or abnormal mucus in stool Population- Frail elderly,
Extensive abdominal cramping or pain immunocompromised, pregnant,
Fever >38.5˚C less than 2 years
Frail elderly
Immunocompromised (e.g., HIV infection, immunosuppressants)
Persistent or chronic diarrhea >14 days
Persistent vomiting for >4 h
Pregnancy
Presence of chronic medical conditions (e.g., diabetes, heart failure, kidney dysfunction)
Recent use of antibiotics particularly those associated with C. difficile colitis (e.g., clindamycin, ampicillin,
cephalosporins)
Severe diarrhea (>6 unformed stools per day for >48 h)
Signs or symptoms of debilitating dehydration (Table 3 and Figure 1)
Weight loss due to diarrhea
Worsening diarrhea
Young age (<2 y)
16,17
Table 3: Signs and Symptoms of Dehydration in Children and Adults
Children Adults
Dry mouth, tongue and skin Increased thirst

Few or no tears when crying Decreased urination
Decreased urination (less than 4 wet diapers in 24 h) Feeling weak or lightheaded
Sunken eyes, cheeks or abdomen Dry mouth/tongue
Greyish skin
Sunken soft spot (fontanel) in infants
Decreased skin turgor (Figure 1)
Irritability or listlessness
Figure 1: Decreased Skin Turgor
An assessment and management plan for patients suffering from diarrhea not related to travel is illustrated in Figure 2.
Prevention
Nonpharmacologic Preventive Measures

Encourage handwashing after going to the toilet or changing a diaper and before preparing and eating food.
Transmission of GI infections in the childcare setting is reduced significantly if infection control procedures are
followed. High compliance with handwashing decreases episodes of diarrhea by 66%.18
Avoid lactose-containing products if lactose intolerance is suspected or diagnosed.
Avoid gluten-containing products if celiac disease is diagnosed.
Encourage maintenance of a diet diary to uncover food intolerances or sensitivities and consider an
elimination diet to see if improvement of symptoms occurs.
Prevent food poisoning:19
Avoid milk and fruit juices that are unpasteurized
Cook foods thoroughly, especially red meat, poultry and eggs
Eat foods soon after they have been cooked so that pathogens do not have time to grow
Rinse foods that are not cooked before they are eaten (fresh fruits and vegetables) under running water
Keep hot foods hot (60°C) and cold foods cold (4°C)
When preparing raw meats and poultry, keep them separated from cooked food, fresh fruits and
vegetables
Use separate cutting boards for raw meats and vegetables
Reheat foods completely when serving leftovers
Wash hands with hot, soapy water before and after preparing food
Use mild solution of hot water and soap to clean counters, cutting boards and utensils
Protect food from insects and animals.
Pharmacologic Preventive Measures
Two vaccines are available to protect against rotavirus infection (Table 10).20,21,22
Probiotics are live microorganisms (bacteria and yeast) that exert a beneficial effect by improving the balance of
the host's intestinal flora.23,24
There are few well-designed clinical trials of the use of probiotics to prevent or treat diarrhea. However, in children,
Lactobacillus rhamnosus strain GG (e.g., Culturelle) may reduce the duration of diarrhea due to rotavirus24 and
decrease the incidence of antibiotic-associated diarrhea.25,26
Saccharomyces boulardii (e.g., Florastor) has been effective for prevention of antibiotic-associated diarrhea in adults
and children as well as prevention of recurrence of C. difficile diarrhea in adults.27 This effectiveness does not
extend to elderly, hospitalized patients.28,29,30 It is generally well tolerated; however, it can cause fungaemia
particularly in immunocompromised patients.27,31,32,33,34,35
The combination of Lactobacillus bulgaricus, Streptococcus thermophilus and Lactobacillus casei Defensis
(DanActive) may be helpful in reducing severity of acute diarrhea in infants and young children.36,37,38 It may also
prevent antibiotic-associated diarrhea caused by C. difficile in hospitalized adults.36,37,38
Administering a daily dose of fermented milk combining L. acidophilus CL1285 and L. casei (e.g., Bio-K) is another
effective option for preventing antibiotic- and C. difficile-associated diarrhea.39,40 Daily administration of
Lactobacillus reuteri DSM 17938 (e.g., Bio-Gaia) or Lactobacillus plantarum 299v (e.g., Metagenics Ultra Flora
Intensive Care; TuZen) were also shown to be effective in preventing antibiotic-associated diarrhea.41,42 Enteral
administration of Lactobacillus plantarum 299v was also shown to decrease colonization by C. difficile in critically ill
patients.43
Most probiotics appear relatively safe.44 There have been isolated reports of serious adverse effects, including a
case report of liver abscess due to L. rhamnosus in a 74-year-old diabetic with Mirizzi syndrome.45 Probiotics
should be used cautiously in patients who are immunosuppressed or have a badly damaged GI tract.23
Dairy products and many commercially available probiotics may contain organisms that, unlike L. rhamnosus strain
GG, have not been shown to survive in the human GI tract.23 Yogurt and kefir, in particular, have not been shown to
prevent antibiotic-associated diarrhea.46,47 Product standardization can also be a problem. Despite this
heterogeneity, the overall evidence suggests a protective effect of probiotics in preventing antibiotic-associated
diarrhea.48 Products may contain microorganisms not listed on the label or contain quantities of microorganisms
other than that listed.49 As a result, the health benefits of one strain cannot be extrapolated to probiotics in general
particularly those of unknown strain composition.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Oral
Rehydration Products.
Rehydration and maintaining electrolyte balance are the cornerstones of therapy for diarrhea.50 Oral rehydration
therapy (ORT) can treat the majority of patients with diarrhea as well as prevent most diarrhea-related complications.6
Oral rehydration solution (ORS) utilizes the sodium/glucose-coupled absorption mechanism in the small intestine.51
ORS is composed of sodium and glucose in the concentration and osmolarity of the luminal fluid. It is recommended by
the World Health Organization (WHO) and should be used early, particularly when treating children and the elderly.
Diarrhea is the second leading cause of child deaths with 1.9 million children dying yearly mainly from dehydration.52
The WHO along with UNICEF currently advocate the use of a new ORS formulation which has a decreased osmolarity of
245 mOsm/L compared with an osmolarity of 311 mOsm/L in the previous formulation. This new formulation was
recommended in 2002 and has decreased concentrations of glucose and sodium chloride. Studies have shown that a
reduced-osmolarity solution decreases stool output by 20%, reduces vomiting by 30% and decreases the need for
intravenous therapy by about 30%.53,54 The WHO formula for ORS is presented in Table 4 as are those of the
commercially available Gastrolyte, Pedialyte and Hydralyte.55,56,57 It should be noted that liquid Hydralyte can be stored
in the refrigerator for 30 days once opened compared with 24 and 48 hours for Gastrolyte and Pedialyte respectively.
The use of fruit juices, pop or tea with sugar is unsuitable due to the high carbohydrate concentration of these drinks.
Homemade ORS can also be used although this is discouraged because mixing errors often occur. Examples of
homemade ORS recipes are described in Table 5.
Table 4: Composition of Oral Rehydration Solution Preparations

Component WHO Gastrolyte Pedialyte Hydralyte
Sodium (mmol/L) 75 60 45 45
Potassium (mmol/L) 20 20 20 20
Chloride (mmol/L) 65 60 35 45
Bicarbonate (mmol/L) 30 10
Citrate (mmol/L) 10 10
Glucose (mmol/L) 75 81
(as
monohydrate)
Dextrose (g/L) 17.8 25
58,59
Table 5: Recipes for Homemade Oral Rehydration Solution
Ingredients Amount
Recipe #1 Fruit juice 240 mL (1 cup)

Honey (pasteurized) 2.5 mL (one-half teaspoonful)
Salt 0.5 mL (one-eighth teaspoonful)
Baking soda 1 mL (one-quarter teaspoonful)
Recipe #2a Purified water 1 L (4 cups)

Salt 2.5 mL (one-half teaspoonful)
Sugar 30 mL (2 tablespoonfuls)
a Amount of sugar in original reference is reduced from 40 mL to 30 mL, to match the current WHO recommendations.
ORT is contraindicated in the following instances:60
Protracted vomiting despite small frequent feedings

Worsening diarrhea and an inability to keep up with losses
Stupor or coma
Intestinal ileus.
Rapid refeeding with age-appropriate foods should immediately follow rehydration.50 Withholding food for bowel rest,
formula dilution and systematic elimination of lactose are no longer standard recommendations.
Children
In most cases, diarrhea in children is self-limiting and non-life-threatening. However, this population can be more
susceptible to the adverse consequences of dehydration and should be monitored closely.
The treatment of childhood diarrhea focuses on correcting dehydration with ORT. Although oral rehydration
solutions are readily available, effective, safe and economical, they are often underutilized.50 Underutilization may
be due to the inconvenience of ORT administration and a preference for intravenous versus oral rehydration.
Breastfeeding should be continued during episodes of diarrhea50 and ORS should be offered. If a child is not being
breastfed, age appropriate foods should be given as well as ORS as described in Table 6. ORT should start as soon
as diarrhea begins and continue until diarrhea is less frequent.
16
Table 6: Administration of Oral Rehydration Solution to Non-breastfed Infants
Age of Child Amount of Oral Rehydration Solution to Give
0–6 months 30–90 mL every hour
6–24 months 90–125 mL every hour
>2 y 125–250 mL every hour
Even if a child refuses ORS by the cup or bottle, the solution is to be given by a medicine dropper or small teaspoon.
If vomiting occurs, ORS should be continued with a spoon, giving 15 mL every 10–15 minutes until vomiting stops,
then resuming with the regular amount (Table 6). If vomiting does not stop after 4–6 hours, the child should
undergo further assessment.
Early refeeding should begin within 6 hours of beginning ORS. For infants who are formula-fed, start with small,
frequent feedings of the child's usual formula. If the diarrhea persists for 2 days, switch to a soy-based or lactose-
free formula as lactose intolerance may be suspected.60
For older children, early refeeding with age-appropriate, previously tolerated foods is recommended.50,60 After 24–
48 hours, the child's normal diet can resume. It may take 7–10 days for stools to become completely formed.
Restricting a child to a complex carbohydrate diet (e.g., BRATT diet: bananas, rice, applesauce, tea and toast) is
inappropriate.61
For dehydrating, persistent diarrhea the use of hypo-osmolar ORS (e.g., the new WHO ORS, Gastrolyte, Pedialyte,
Hydralyte) is beneficial and superior to the older iso-osmolar WHO ORS (see Table 4).62 Hypo-osmolar ORS results
in a shorter period of diarrhea, less stool output and less need for maintenance therapy.
Antidiarrheal medications are indicated for relief of debilitating symptoms that accompany diarrheal illness. Select
agents useful in the management of diarrhea are described in Table 11.
For further discussion of pharmacologic therapy for diarrhea, consult the Compendium of Therapeutic Choices:
Diarrhea.
Gastrointestinal Products: Antidiarrheals.
The World Health Organization and UNICEF now recommend supplementation with zinc 20 mg daily for 10–14 days for
infants >6 months and 10 mg per day for infants <6 months of age. Zinc supplementation decreases both the severity
and the duration of acute or persistent diarrhea in children.52,63,64 Supplementing with a combination of micronutrients
and vitamins is not superior to zinc alone.65 The addition of zinc and prebiotics to ORS limits the duration of diarrhea in
children.66
Other pharmacologic therapies for diarrhea include:
Cholestyramine: useful in treatment of bile acid-induced diarrhea1

Fidaxomicin, metronidazole and oral vancomycin: useful in treating diarrhea due to C. difficile67,68
Codeine: doses necessary for antidiarrheal effect may not be safely attainable with nonprescription products and
may result in acetaminophen toxicity
Clonidine: effective against diarrhea associated with opioid withdrawal and diabetic autonomic neuropathy1
Diphenoxylate with atropine: less effective than loperamide69
Octreotide: useful in diarrhea due to chemotherapy, short bowel syndrome, neuroendocrine tumors, AIDS-
associated diarrhea and other chronic diarrhea not responding to standard treatment.70,71

Natural health products that have been used for the treatment of diarrhea include German chamomile, carob,
marshmallow, slippery elm, bayberry, blackberry leaf, raspberry leaf, bilberry, agrimony, quercetin and berberine.72
None have been found to be effective.
Pregnancy
Acute diarrhea in pregnancy is mainly due to viral or bacterial causes and is usually self-limiting. Maintenance of
fluid intake is important. Bulking agents may be of use and systemic agents such as loperamide should be reserved
for severe cases when the risk of dehydration outweighs the risk of the drug used.73
Elderly
The elderly are particularly susceptible to dehydration due to diarrhea. Nursing homes are similar to childcare
settings where pathogens are spread by the oral-fecal route. Prompt rehydration is essential to avoid damage to
vital organs.
Table 7: Monitoring of Therapy for Diarrhea

Symptoms Monitoring Endpoint Actions
Loose, watery stools Patient: Regularly as long Resolution of Antidiarrheal medications

as symptoms persist. symptoms. Return to may be necessary within
Healthcare practitioner: usual bowel evacuation first 2 days to alleviate
Ask for symptom report; pattern. symptoms.
call patient within 48 h to If symptoms persist
see if symptoms have beyond 48 h, seek medical
resolved. attention.
Signs and symptoms Patient: Continually. No signs of If signs of dehydration

of dehydration dehydration. (Table 3 and Figure 1)
(Table 3) occur despite oral
rehydration therapy,
reassess.
Fever or blood in stools Patient: Regularly as long No fever; no blood in Reassess if this occurs.
as symptoms persist. stools.
.....
Travellers' Diarrhea
Introduction
Travellers' diarrhea (TD) is known by many colloquial names including Montezuma's revenge, GI trots, Turkey trots,
turista and Delhi belly. It is defined by 3 or more loose, unformed stools per day along with at least 1 symptom of
enteric infection such as fever, abdominal cramps, nausea, fecal urgency or dysentery.74 TD is a generally self-limiting
illness which usually resolves within 3–4 days even without treatment. However, infants, the elderly, patients with
severe chronic diseases (e.g., chronic renal failure, heart failure, insulin-dependent diabetes mellitus, inflammatory
bowel disease) and immunocompromised hosts may experience significant complications. It is estimated that TD
could affect up to 50% of persons travelling from industrialized countries to developing countries like Latin America,
Asia and Africa.75 In many cases symptoms develop during the first week of travel and more than 90% of cases occur
within the first 2 weeks of travel.76 An episode of TD does not protect against future attacks and more than 1 episode
could be experienced in a single trip.77,78
Pathophysiology
TD is associated with food or water that is contaminated by bacteria, viruses or parasites (Table 8). However, up to 50%
of TD cases may have no identifiable cause.79 The microorganisms are primarily spread by the fecal-oral route and vary
depending on the geographical area visited as well as the time of year (more in summer months and rainy seasons.)
Low-risk areas include Canada, the United States, Australia, New Zealand, Japan, and Northern and Western Europe.
Intermediate-risk areas include Southern Europe, South Africa, Israel, Russia and some Caribbean Islands (e.g., Haiti
and Dominican Republic). High-risk areas include large areas of Asia, Africa and Latin America.76,80,81 Factors
associated with an increased likelihood of acquiring TD include travel from an industrialized country to a developing
tropical or semitropical region, contraction of TD on a previous trip, low-budget or adventure travel, adventurous eating
habits, daily use of proton pump inhibitors and a relative lack of gut immunity seen in younger individuals.58,80,82
Table 8: Common Causes of Travellers' Diarrhea

Bacterial (up to 80% of cases) Viral (5–25% of cases) Parasitic (up to 10% of cases)
Aeromonas spp.—common in Norwalk virus Cryptosporidium spp.—common in

Thailand Rotavirus Russia
Campylobacter jejuni—common in Astrovirus Cyclospora cayetanensis—
Mexico, Thailand, Morocco (dry common in Guatemala, Haiti,
winter) Enteric adenoviruses Nepal and Peru
Enterotoxigenic Escherichia coli Cystoisospora belli
(ETEC)—common in Latin America, Dientamoeba fragilis
Africa
Entamoeba histolytica
Plesiomonas spp.
Giardia lamblia—common in Nepal
Salmonella spp. and Russia
Shigella spp.
Vibrio cholerae—common in Bali,
Ecuador, India and Indonesia
Yersinia spp.
Goals of Therapy
Assess/reduce the risk of experiencing TD at the travel destination
Assess patient's existing medical conditions that may contribute to experiencing TD
Educate travellers about food hygiene and safe drinking water to reduce the risk of TD
Educate travellers about effective treatment regimens in case they experience symptoms
Educate travellers about when to be evaluated by a healthcare practitioner
Minimize suffering/interruption of vacation or business plans and associated costs
Prevent complications such as dehydration
Reduce symptoms in the period immediately following travel
Patient Assessment
Assess travellers to determine their risk of experiencing TD before travel. This assessment allows patients at increased
risk to seek appropriate medications before travelling.
Risk factors for developing TD or its complications include:

Children or young adults (particularly those with adventurous eating habits)
Destination has poor standards of hygiene, accommodation or sanitation amenities (e.g., Africa, most of Asia,
Central and South America and Middle East)
Elderly or frail
Immunocompromised
Inflammatory bowel disease
Reduced stomach acidity
Diabetes
Travelling to remote areas with few or no medical amenities.
The assessment and management of TD is illustrated in Figure 3. Any red flags would require further detailed
assessment (Table 2).83
Prevention
The incidence of TD can be minimized by choosing appropriate foods and avoiding those associated with the illness
(Table 9).
Table 9: Food and Travellers' Diarrhea

Safe Foods/Beverages Unsafe Foods/Beverages
Beer or wine Buffet food at room temperature

Boiled or bottled water Cold salads
Carbonated beverages (with no Condiments in open bottles
ice cubes) Custards, mousses, mayonnaise, hollandaise sauce
Cooked vegetables Food from street vendors
Dry food (e.g., bread) Fresh soft cheese
Hot beverages (e.g., tea, coffee) Ice cubes/chips
Pasteurized milk (if properly Large reef fish from the Caribbean and South Pacific (e.g., snapper,
stored) barracuda, grouper, jack, moray eel)
Peeled fruit (preferably done by Leafy and/or raw vegetables
self)
Leftovers
Piping hot food
Raspberries/strawberries/watermelon
Thoroughly and recently cooked
meats and fish Shellfish
Uncooked, cold sauces
Undercooked hamburger/meat/fish
Unpeeled fruit
Other measures that travellers should follow include:
Follow the adage “Boil it, cook it, peel it or forget it”
Use purified water or water from the hot tap to brush teeth
Wash hands frequently while travelling, particularly before handling or consuming food (if soap and water are
unavailable, consider using commercially available waterless hand sanitizing agents)58
Avoid drinking the water while swimming
Avoid drinking local water
Drink bottled beverages in their original containers and ensure the cap is sealed
Bismuth subsalicylate is 60–65% effective as a prophylactic agent58 (Table 12) and may be used to prevent TD.
Consider antibiotic prophylaxis only in selected cases:
People who cannot tolerate even a brief illness (e.g., elite athletes, business or political travellers)
People at high risk of TD due to achlorhydria, gastrectomy or history of repeated episodes of severe TD
Those who are immunosuppressed
Those with chronic illness at increased risk of experiencing complications due to TD.
Routine antibiotic prophylaxis is not recommended for a number of reasons which include antibiotic resistance,
photosensitivity reactions, severe allergic reactions (e.g., Stevens-Johnson syndrome), C. difficile-associated diarrhea
and candidal vaginitis.77
A number of studies have shown the effectiveness of probiotics such as Lactobacillus GG (e.g., Culturelle) and
Saccharomyces boulardii (e.g., Florastor) to prevent TD. These regimens typically involve starting the probiotic 2–3 days
before travel and continuing until the end of travel or until 2 days after returning from travel. While routine
recommendations are not yet advised, studies continue to show promise. However, these data should not be
extrapolated to all strains of probiotics since variation can be present.87,88
Methods for purifying untreated water are discussed in Information for the Traveller.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Oral
Rehydration Products.
Travellers are advised to maintain and possibly increase their fluid intake during bouts of diarrhea, though dehydration
is not a major concern. Health Canada suggests that children and the elderly use ORS, while healthy adults maintain
hydration with canned juices, purified water, carbonated soft drinks or clear salty soups to maintain light-coloured urine
and relieve thirst.58 Dairy products, alcohol, caffeine, prune juice, orange juice and apple juice should be avoided.
Select agents for the prevention of TD are described in Table 12. Table 13 lists some medications used in the treatment
of TD. For further discussion of pharmacologic therapy for travellers' diarrhea, consult the Compendium of Therapeutic
Choices: Travellers' Diarrhea.
Gastrointestinal Products: Antidiarrheals.
Antibiotics useful in treating TD include the fluoroquinolones (ciprofloxacin, levofloxacin, norfloxacin or ofloxacin) and
azithromycin.88 Azithromycin is particularly useful in pregnant patients or children since fluoroquinolones are
contraindicated in these populations. Azithromycin may be preferred over the fluoroquinolones where ciprofloxacin-
resistant Campylobacter is a growing concern (e.g., Asia).88
Sulfamethoxazole/trimethoprim and doxycycline are of limited use due to widespread resistance.58 Prior to departure,
travellers should have antibiotics on hand for use in case of diarrhea while travelling in order to reduce duration and
severity of the illness.89
Goldenseal (Hydrastis canadensis) has been used to treat TD. The primary active constituent is thought to be berberine.
There are insufficient human data to support the efficacy of goldenseal or berberine in the treatment of infectious
diarrhea. The dose of berberine sulfate used in clinical studies was 400 mg per day given in 1–4 divided doses. The
adult dose of dried herb is 0.5–1 g, 3 times daily. Safety in children or during breastfeeding has not been established.
Goldenseal is contraindicated during pregnancy. The use of goldenseal extracts as outlined appears safe. However,
administration of high doses of berberine may result in serious adverse effects (e.g., hypertension, seizures, respiratory
failure).90,91
Patients can monitor their condition based on the frequency and severity of symptoms. They can expect a fairly brief
illness if they take medication and in some cases even without medication.58 Monitoring includes reduction of loose,
watery stools to ≤1 per day within 2–3 days.58,83 Medical attention should be sought if the patient develops signs of
dehydration, or if a child <2 years develops bloody stools, a rectal temperature >38.5°C or persistent vomiting.58,83 If
symptoms persist longer than 14 days without pharmacologic treatment or longer than 2 days despite optimum
pharmacologic treatment a healthcare practitioner should be consulted.
.....
Algorithms
9,16
Figure 2: Assessment and Management of Patients with Diarrhea Not Related to Travel
58,83
Figure 3: Assessment and Self-management of Travellers' Diarrhea
Abbreviations: BSS = bismuth subsalicylate; ORT = oral rehydration therapy; TD = travellers' diarrhea
Drug Tables
Table 10: Vaccines for Rotavirus Prevention
Vaccines rotavirus 3 total doses Mild fever Immunosuppressive Contains 5 $60
pentavalent, First dose (20%), diarrhea therapies (e.g., anti- rotavirus
live oral usually given (24.1%), TNF-α agents) strains
vaccine between 6 and vomiting passed from the responsible for
RotaTeq 12 weeks of (15.2%), otitis mother to the fetus about 95% of
age; media (14.5%), may remain in the rotavirus
subsequent bronchospasm newborn’s blood for disease in
doses should (1.1%). up to 6 months Canada. 85–
have 4–10 wk postdelivery; avoid 98% effective
between them. administering any against severe
Can be given live vaccines to the rotavirus
with other newborn until at disease. Can
routine least 6 months of decrease
immunizations age. hospitalizations
by up to 96%.
Vaccines rotavirus 2 total doses Rarely Immunosuppressive 85–98% $90

monovalent, First dose intussusception therapies (e.g., anti- effective
live oral usually given (type of bowel TNF-α agents) against severe
vaccine after 6 weeks blockage). passed from the rotavirus
Rotarix of age; mother to the fetus disease.
subsequent may remain in the
dose given at newborn’s blood for
least 4 wk up to 6 months
later but no postdelivery; avoid
later than 24 administering any
weeks of age. live vaccines to the
Can be given newborn until at
with other least 6 months of
routine age.
immunizations
a Cost per dose; includes drug cost only.
Table 11: Nonprescription Drug Therapy for Diarrheaa

Class Drug Dosage Adverse Drug Comments Costb
Adsorbent attapulgite >12 y: Well No known drug May be useful $
Agents Kaopectate 1200–1500 tolerated. interactions. for treatment of
mg po mild to
initially, then moderate acute
1200–1500 diarrhea.
mg after
each BM
Maximum:
8400
mg/day
6–12 y:
600–750
mg po
initially, then
600–750
mg after
each BM
Maximum:
4200 mg per
day
3–5 y: 300
mg po
initially, then
300 mg
after each
BM
Maximum:
2100 mg per
day
Antimotility loperamide >12 y: 4 mg Abdominal Concomitant Do not use in $
Agents Imodium, po initially, cramps or administration children <3 y or
generics then 2 mg discomfort, of loperamide in those who
after each drowsiness, with quinidine are
loose BM dizziness, or ritonavir malnourished,
Maximum: dry mouth, may increase moderately or
16 mg per skin rash. loperamide's severely
day plasma levels. dehydrated or
9–12 y: 2 systemically ill
mg TID po or in those with
for 1 day bloody
then 0.1 diarrhea. Use
mg/kg/dose with caution in
after each children <12 y.
loose BM Discontinue if
(not to symptoms
exceed 2 persist longer
mg/dose) than 48 h.
Opiate-like CNS
6–8 y: 2 mg effects have
BID po for 1 been observed
day then 0.1 in children <3 y.
mg/kg/dose Monitor
after each patients with
loose BM hepatic
(not to dysfunction for
exceed 2 signs of CNS
mg/dose) toxicity.
2–5 y: 1 mg
TID po for 1
day then 0.1
mg/kg/dose
after each
loose BM
(not to
exceed 1
mg/dose)
Antisecretory bismuth >14 y: 524 Black Avoid in Used to treat $

Agents subsalicylate mg every tongue and patients taking chronic
Pepto- 30–60 min stools, anticoagulants, idiopathic
Bismol, PRN po tinnitus. methotrexate, diarrhea with a
generics (maximum probenecid, reduction in
4.2 g/day) salicylates. stool weight
10–14 y: and frequency.
262 mg Bismuth
every 30–60 subsalicylate is
min PRN po available as a
(maximum 17.6 mg/mL
2.1 g/day) liquid or 262
mg tablets.
5–9 y: 131
mg every
30–60 min
PRN po
(maximum 1
g/day)
2–4 y: 88
mg every
30–60 min
PRN po
(maximum
0.7 g/day)
Hydrophilic psyllium Adults: up Cramping, Concomitant Separate $
Bulking Metamucil to 40 g/day flatulence. administration administration
Agents Preparations, po in 2–4 may interfere of other
generics divided with the medications by
doses absorption of 2 h.
Children >6 carbamazepine Contraindicated
y: 5 g up to and lithium. in patients with
2–4 times dysphagia.
daily po Allergic
reactions have
occurred.
Esophageal
obstruction has
occurred when
insufficient
liquid was
administered
with the dose.
a For more information on pharmacologic therapy for diarrhea, consult the Compendium of Therapeutic Choices: Diarrhea.
b Cost per day; includes drug cost only.
Legend: $ <$1
Table 12: Drug Therapy for Prevention of Travellers' Diarrheaa

Antisecretory bismuth >14 y: 524 Black Avoid in Avoid in $

Agents subsalicylate mg QID po tongue/stool, patients taking patients with
Pepto- 10–14 y: 262 tinnitus. anticoagulants, history of ASA
Bismol, mg QID po methotrexate, allergy, renal
generics probenecid, insufficiency
5–9 y: 131 salicylates. and gout. Limit
mg QID po Can interfere prophylaxis to
2–4 y: 88 mg with 3 wk. Not for
QID po absorption of children <2 y.
doxycycline Can decrease
Start 1 day
(which may be incidence of
before travel
used for travellers'
and continue
malaria diarrhea from
until 2 days
prevention). 40% to 14%.
after leaving
destination
Vaccines cholera >2 y: 2 doses No Separate About 43% $40/dose

vaccine, po significant or administration short-term
inactivated First dose at common of protection
oral least 2 wk adverse encapsulated against
Dukoral before effects. oral typhoid diarrhea
departure vaccine by at caused by
Second dose least 8 h. enterotoxigenic
1 wk after the Oral E. coli.84,85
first dose and administration A booster dose
at least 1 wk of other is required
before vaccines and every 3 months
departure medicinal if the risk is
If more than products ongoing. Food
6 wk elapse should be should be
between the avoided 1 h avoided 1 h
first and before and 1 h before and
second dose, after after
the primary vaccination. administration.
immunization
should be Not
restarted recommended
for routine use
since it may
not be effective
for prevention
of TD;86 can be
considered
when risk is
high.
a
For more information on pharmacologic prevention of travellers' diarrhea, consult the Compendium of Therapeutic Choices:
Travellers' Diarrhea.
b
Cost per day unless otherwise specified; includes drug cost only.
Legend: $ <$1
Table 13: Drug Therapy for Treatment of Travellers' Diarrheaa

Antimotility loperamide Prevention: Abdominal Concomitant Do not use in $
Agents Imodium, Not cramps or administration children <3 y
generics recommended discomfort, of loperamide or in those
Treatment: drowsiness, with quinidine who are
>12 y: 4 mg dizziness, or ritonavir malnourished,
stat then 2 mg dry mouth, may increase moderately or
after each skin rash. loperamide's severely
loose BM po plasma levels. dehydrated or
Maximum: 16 systemically
mg per day ill or in those
9–12 y: 2 mg with bloody
TID po for 1 diarrhea. Use
day then 0.1 with caution
mg/kg/dose in children
after each <12 y.
loose BM (not Discontinue if
to exceed 2 symptoms
mg/dose) persist longer
than 48 h.
6–8 y: 2 mg Opiate-like
BID po for 1 CNS effects
day then 0.1 have been
mg/kg/dose observed in
after each children <3 y.
loose BM (not Monitor
to exceed 2 patients with
mg/dose) hepatic
2–5 y: 1 mg dysfunction
TID po for 1 for signs of
day then 0.1 CNS toxicity.
mg/kg/dose
after each
loose BM (not
to exceed 1
mg/dose)
Antisecretory bismuth 2 × 262 mg Black Avoid in Bismuth $

Agents subsalicylate tablets or tongue and patients taking subsalicylate
Pepto- equivalent stools, anticoagulants, is also
Bismol, suspension tinnitus. methotrexate, available as a
generics every 30 min × probenecid, 17.6 mg/mL
8 doses salicylates. suspension.
a For more information on pharmacologic therapy for travellers' diarrhea, consult the Compendium of Therapeutic Choices:
Travellers' Diarrhea.
Legend: $ <$1
Suggested Readings
Diarrhea
Guarino A, Dupont C, Gorelov AV et al. The management of acute diarrhea in children in developed and developing
areas: from evidence base to clinical practice. Expert Opin Pharmacother 2012;13:17-26.
Hempel S, Newberry SJ, Maher AR et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a
systematic review and meta-analysis. JAMA 2012;307:1959-69.
McClarren RL, Lynch B, Nyayapati N. Acute infectious diarrhea. Prim Care 2011;38:539-64.
Parashar UD, Gibson CJ, Bresse JS et al. Rotavirus and severe childhood diarrhea. Emerg Infect Dis 2006;12:304-6.
Pilotto A, Franceschi M, Vitale D et al. The prevalence of diarrhea and its association with drug use in elderly
outpatients: a multicenter study. Am J Gastroenterol 2008;103:2816-23.
Venugopal AA, Johnson S. Current state of Clostridium difficile treatment options. Clin Infect Dis 2012;55:S71-6.
Travellers' Diarrhea
Kollaritsch H, Paulke-Korinek M, Wiedermann U. Traveler's diarrhea. Infect Dis Clin North Am 2012;26:691-706.
Paredes-Paredes M, Flores-Figueroa J, Dupont HL. Advances in the treatment of travelers' diarrhea. Curr Gastroenterol
Rep 2011;13:402-7.
Shah N, DuPont HL, Ramsey DJ. Global etiology of travelers' diarrhea: systematic review from 1973 to the present. Am J
Trop Med Hyg 2009;80:609-14.
Singh E, Redfield D. Prophylaxis for travelers' diarrhea. Curr Gastroenterol Rep 2009;11:297-300.
References
1. Deepak P, Ehrenpreis ED. Diarrhea. Dis Mon 2011;57:490-510.

2. Wanke C. Epidemiology and causes of acute diarrhea in resource rich countries. Available from:
www.uptodate.com. Accessed May 4, 2015. Subscription required.
3. Sandler RS, Stewart WF, Liberman JN et al. Abdominal pain, bloating and diarrhea in the United States:
prevalence and impact. Dig Dis Sci 2000;45:1166-71.
4. Manatsathit, S, Dupont HL, Farthing M et al. Guideline for the management of acute diarrhea in adults. J
Gastroenterol Hepatol 2002;17:S54-71.
5. Lamberti L, Fischer Walker CL et al. Systematic review of diarrhea duration and severity in children and adults in
low-middle income countries. BMC Public Health 2012;12:276.
6. Ladinsky M, Duggan A, Santosham M et al. The World Health Organization oral rehydration solution in US
pediatric practice: a randomized trial to evaluate parent satisfaction. Arch Pediatr Adolesc Med 2000;154:700-5.
7. World Gastroenterology Organisation Global Guidelines. Acute diarrhea in adults and children: a global
perspective. February 2012 p. 3. Available from: www.worldgastroenterology.org/guidelines/global-
guidelines/acute-diarrhea/acute-diarrhea-english. Accessed May 4, 2015.
8. World Health Organization. Ending preventable deaths from pneumonia and diarrhea by 2025. Available from:
www.who.int/maternal_child_adolescent/news_events/news/2013/gappd_launch/en. Accessed May 4, 2015.
9. Grimwood K, Forbes DA. Acute and persistent diarrhea. Pediatr Clin North Am 2009;56:1343-61.
10. Dennehy PH. Rotavirus infection: an update on management and prevention. Adv Pediatr 2012;59:47-74.
11. Thomas RE, Wyer M. Nausea, vomiting, diarrhea and constipation. In: Herfindal ET, Gourley DR, Hart LL, eds.
Clinical pharmacy and therapeutics. 4th ed. Baltimore: Williams & Wilkins; 1998. p. 306-7.
12. U.S. National Library of Medicine. MedlinePlus. Eisner T. Drug-induced diarrhea. Updated November 2, 2014.
Available from: www.nlm.nih.gov/medlineplus/ency/article/000293.htm. Accessed May 4, 2015.
13. Owens RC, Donskey CJ, Gaynes RP et al. Antimicrobial-associated risk factors for Clostridium difficile infection.
Clin Infect Dis 2008;46:S19-31.
14. Mehta DI, Blecker U. Chronic diarrhea in infancy and childhood. J La State Med Soc 1998;150:419-29.
15. Bowen R. Pathophysiology of diarrhea. Updated July 27, 2006. Available from:
www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/diarrhea.html. Accessed May 4, 2015.
16. Canadian Paediatric Society. Caring for Kids. Dehydration and diarrhea in children: prevention and treatment.
Updated June 2013. Available from: www.caringforkids.cps.ca/handouts/dehydration_and_diarrhea. Accessed
February 8, 2016.
17. Thomas DR, Cote TR, Lawhorne L et al. Understanding clinical dehydration and its treatment. J Am Med Dir
Assoc 2008;9:292-301.
18. Roberts L, Jorm L, Patel M et al. Effect of infection control measures on the frequency of diarrheal episodes in
child care: a randomized, controlled trial. Pediatrics 2000;105:743-6.
19. Canadian Paediatric Society. Caring for Kids. Food safety at home. Updated October 2014. Available from:
www.caringforkids.cps.ca/handouts/food_safety_at_home. Accessed February 8, 2016.
20. Kollaritsch H, Wiedermann U. [Examples for vaccines against diarrheal diseases—rotavirus and traveller's
diarrhea]. Wien Med Wochenschr 2007;157:102-6. [German].
21. CPS online. Ottawa: Canadian Pharmacists Association; 2015. Rotarix [product monograph]. Available from:
www.e-therapeutics.ca. Subscription required.
22. CPS online. Ottawa: Canadian Pharmacists Association; 2013. RotaTeq [product monograph]. Available from:
www.e-therapeutics.ca. Subscription required.
Dyspepsia and GERD
Co Q. D. Pham, BSc, BA, BScPharm, ACPR, PharmD

Introduction
Dyspepsia is defined as a chronic or recurrent epigastric (upper abdomen) pain or burning, postprandial fullness or early satiety with
no evidence of structural disease to explain the symptoms.1 Other symptoms may also include bloating, nausea or vomiting.1 In
contrast, the predominant symptom in gastroesophageal reflux disease (GERD) is troublesome or frequent acid regurgitation or
heartburn (a burning feeling in the stomach or lower chest rising up to the neck).2 GERD is also associated with epigastric pain,
nausea, dysphagia (difficulty swallowing) and odynophagia (pain with swallowing).2 Extraesophageal or atypical manifestations of
GERD are also possible and include cough, sore throat, chest pain, hoarseness, shortness of breath and wheezing.2,3,4,5,6,7,8,9 It is
important to recognize that there is considerable symptom overlap between dyspepsia and GERD, and it may be difficult to
differentiate between them in a patient who has not been investigated.3
Although the incidence of dyspepsia is poorly documented, the prevalence rate in western countries approximates 25%; if heartburn
symptoms are also considered then the prevalence rate increases to 40%.1,4 GERD has a prevalence of approximately 40%, and up
to half of the sufferers may show erosive esophagitis upon endoscopic investigation.3,5,10 GERD with a normal esophagus at
endoscopy is referred to as nonerosive reflux disease (NERD) or as endoscopy-negative reflux disease (ENRD). Dyspepsia and GERD
remain costly chronic conditions where a significant proportion of patients self-manage without seeking medical attention.5,11
Pathophysiology
Dyspepsia
Dyspepsia can be caused by identifiable abnormalities such as chronic peptic ulcer disease (PUD), GERD and gastric or
esophageal cancer (Table 1).1,3,4 Dyspepsia is referred to as functional, idiopathic or nonulcer dyspepsia (NUD) when no
identifiable structural or biochemical abnormalities are found (Table 1). The pathophysiology of functional dyspepsia is
considered an overlap of psychosocial factors, upper GI motor abnormalities (delayed gastric emptying, impaired gastric
accommodation to meals) and altered organ sensory function (gastric or duodenal hypersensitivity to mechanical distention or
nerve-related mechano-sensory dysfunction).1,3,4 In general, the symptoms of dyspepsia are minor and infrequent, although with
a relapsing course.1,3,4
Table 1: Causes of Dyspepsia

Structural abnormalities/identifiable causes (40%):
Peptic ulcer disease (15–25%)
Reflux esophagitis (5–15%)
Gastric or esophageal cancer (<2%)
Other diseases: e.g., cholecystitis, pancreatitis, celiac disease, Crohn's disease, sarcoidosis, hypothyroidism,
hypercalcemia, hepatoma, intestinal angina, renal failure, diabetic gastroparesis
Food intolerance: e.g., lactase deficiency
Medications: e.g., acarbose, amiodarone, antibiotics (e.g., erythromycin), bisphosphonates, digitalis, iron
supplements, NSAIDs, potassium supplements, theophylline
Natural health products: e.g., garlic, feverfew, chaste tree berry, white willow
Infections: e.g., cytomegalovirus, Giardia lamblia, Strongyloides stercoralis
No identifiable structural abnormalities or causes (60%)
Functional or idiopathic (nonulcer) dyspepsia

Gastroesophageal Reflux Disease (GERD)
The pathogenesis of GERD is multifactorial and includes:
Defective lower esophageal sphincter (LES); in the normal state, the LES prevents reflux of gastric contents into the
esophagus
Hiatal hernia
Impaired esophageal peristalsis
Delayed gastric emptying
Excessive gastric acid production
Bile reflux.
The pathophysiology of GERD is multifactorial and determining the primary etiology can be challenging. The abnormalities that
contribute to GERD can result from various components in the system, including the esophagus, LES and the stomach. Poor
esophageal motility may decrease the clearance of acidic material. A dysfunctional LES valve can permit reflux of gastric
content. As well, delayed gastric emptying can increase both the volume and pressure in the stomach, overwhelming the LES
valve and leading to GERD. A hiatal hernia (herniation of the stomach above the diaphragm) can also be viewed as part of the
GERD continuum, presenting in patients with severe erosive esophagitis. Therefore, therapy should consider the components
that may be deficient, to apply effective treatment.12,13
GERD symptoms may be exacerbated when a patient bends over, lies down, smokes, is obese, eats certain foods (fatty meals) or
takes certain medications (Table 2).4,5,6 GERD may also result in structural damage to the esophagus, and the resulting
esophagitis can lead to complications such as ulcers, erosions, hemorrhage, strictures, Barrett's esophagus and esophageal
adenocarcinoma. Barrett's esophagus involves the replacement of the normal esophageal squamous epithelium with columnar
intestinal-like epithelium. Studies estimate the annual incidence of esophageal adenocarcinoma among patients with Barrett’s
esophagus to be 0.1–2.9%.14,15 Severity of GERD symptoms is not always related to the severity of structural esophageal
damage. In healthy individuals a certain amount of normal acid-reflux does occur. However, with further refluxate exposure, the
esophagus becomes more vulnerable to damage.7,8,9
Table 2: GERD: Triggers or Exacerbating Factors

Disease states Asthma (possibly)
Sjögren's syndrome
Drugs (reduce lower esophageal sphincter pressure) Alpha-blockers

Anticholinergics
Benzodiazepines
Beta-agonists
Calcium channel blockers
Nicotine
Nitrates
Opioids
Theophylline
Lifestyle Obesity
Smokinga
Diet
fatty foods delay gastric emptying
chocolate,a coffeea and alcohola may reduce LES
tone
carbonated drinks may cause gastric distention and
increased transient lower esophageal sphincter
relaxations
Other Factors Age >65 y

Hiatus hernia
Pregnancy
Stress and anxiety
a
Association with GERD is weak but some patients may experience worsening symptoms.
Goals of Therapy
Reduce or eliminate symptoms
Reduce or prevent recurrence of symptoms (frequency or duration)
Induce healing of any damaged mucosa
Prevent complications such as Barrett's esophagus or esophageal adenocarcinoma
Educate patients to recognize worsening symptoms of GERD
Patient Assessment
For uninvestigated dyspepsia, patient assessment should start with a review of alarm features (Table 3), symptoms and history.
Patients would require prompt investigation and assessment if alarm features are present or if age is >50 years with new onset or
worsening of symptom severity or frequency (Figure 1).
In patients with GERD, a similar initial assessment should review the presence of alarm features (Table 3) and symptoms (Figure
1).5,6 If GERD is not evaluated and treated in a timely manner, complications may arise. These complications include esophageal
inflammation, ulcers, hemorrhage, strictures and cancer as well as anemia, aspiration pneumonia, gingivitis, halitosis and tooth
decay.
1,5
Table 3: Assessment of Dyspepsia and GERD: Alarm Symptoms
Further evaluation is required immediately if the patient experiences any of the following symptoms:
Symptom Description
Chest pain Resembling cardiac pain
Choking Sensation of acid refluxed into the windpipe causing shortness of breath,
coughing or hoarseness
Dysphagia Difficulty swallowing
GI bleeding Vomiting blood or having tarry or black bowel movements
Odynophagia Pain upon swallowing
Unintentional weight loss
Vomiting
Evidence for lifestyle modifications has been inconclusive. Still many patients derive symptomatic benefit from inexpensive and
usually simple measures. Some recommendations are provided in Table 4 and Table 5. These likely have their greatest impact in
patients with mild symptoms.1,16,17
1,17
Table 4: Preventive and Nonpharmacologic Treatments for Dyspepsia
Lifestyle modifications Avoid foods that precipitate events
Avoid lying down right after meals
Achieve ideal body weight
Quit smoking
Reduce alcohol intake
Reduce caffeine intake
Smaller, more frequent meals
Psychological Reassure patients regarding the benign nature of functional dyspepsia

Stress reduction
5,18,19
Table 5: Lifestyle Modifications in the Treatment of GERD
Avoid exercising or bending on a full stomach Avoid tight-fitting
clothes around the waist
Avoid foods that delay gastric emptying or increase acid exposure: chocolate, onions, Elevate head of bed
carminatives (spearmint, peppermint), high-fat meals about 10 cm
Avoid large meals Avoid excessive alcohol

consumption
Limit use of drugs that may cause or worsen dyspepsia (e.g., antibiotics, bisphosphonates, Stop smoking if a
corticosteroids, iron, metformin, NSAIDs, opioids, potassium salts) smoker
Avoid lying down following meals, or eating before bedtime Achieve ideal body
weight if obese
Products: Antacid, Antiflatulent and Antireflux.
For further discussion of pharmacologic therapy for GERD, consult the Compendium of Therapeutic Choices: Gastroesophageal
Reflux Disease.
In the absence of alarm features the initial management of mild or intermittent GERD should consist of diet and lifestyle
modifications. Consider alginates, antacids or histamine type 2 receptor antagonists (H2RAs) for mild and infrequent GERD
symptoms (Figure 1). H2RAs decrease the frequency of nighttime awakenings for GERD. Overall, symptom relief appears similar to
antacids but the duration of effect is longer.23 All H2RAs appear to have similar efficacy. H2RAs may become less effective with
time and may not suppress meal-related acid secretion as well as proton pump inhibitors (PPIs).
PPIs decrease stomach acid production. Studies have demonstrated that PPIs decrease the overall days of symptoms of GERD and
dyspepsia, as well as nighttime symptoms.8 Patients with moderate to severe or frequent symptoms of GERD occurring >2 times
per week can be treated with PPIs. Prokinetic agents or H2RAs may also be useful. Antacids or sodium alginate can be used for
breakthrough symptom control in these patients.3,17
Patients with dyspepsia should be followed up for H. pylori test-and-treat strategy (Figure 1).1 The test-and-treat strategy works on
the principle that 1) some patients with dyspepsia not yet investigated with an endoscope will test positive for H. pylori infection, 2)
patients who are H. pylori positive are more likely to have definite ulcers and 3) treatment of H. pylori in patients with ulcers is likely
to lead to remission of dyspeptic symptoms.
Patients who have ongoing symptoms despite a test-and-treat strategy and a trial of PPIs likely have functional dyspepsia. The
majority of trials have demonstrated that most of the available pharmacologic agents for functional dyspepsia are of no proven
benefit. The natural history of functional dyspepsia is such that the majority of patients improve without therapy.1 Despite this,
almost all patients with functional dyspepsia who seek medical help will be prescribed a drug. However, only a minority of patients
require continuous chronic therapy with medications (PPIs, prokinetic agents, H2RAs) and a significant portion will have difficulty
achieving complete symptom relief.1,3 Step-up therapy (starting with antacids) has similar efficacy to step-down therapy (starting
with PPIs) but treatment cost may be lower for the former.16
Patients with minor or intermittent dyspeptic/GERD symptoms may use an antacid, sodium alginate or H2RAs for symptomatic
therapy (Table 6).
Antacids
Little evidence supports the efficacy of antacids in functional dyspepsia despite their widespread use.20 In GERD, relief of
heartburn occurs in approximately 20% of patients and the esophagus is protected from gastric contents for roughly 1.5
hours.21 Antacids do provide therapeutic benefits in PUD but their inconvenience (frequent dosing, volume) and taste of
suspensions makes other acid suppression therapy more attractive. Four basic types of antacids are available: sodium
bicarbonate, and salts of aluminum, calcium and magnesium. The order of acid-neutralizing potency is aluminum hydroxide
(least potent), followed by magnesium hydroxide, sodium bicarbonate and calcium carbonate (most potent). Some products
contain a combination of salts, especially aluminum and magnesium. The rationale for the aluminum-magnesium combination
is to offset the tendency of the respective agents to cause constipation and diarrhea. Table 6 provides an overview of the
different products and precautions with each agent.
Dosing equivalency amongst antacids is based upon their ability to neutralize a molar amount of acid, which is called the acid
neutralizing capacity (ANC). Doses of 10–40 mEq ANC are commonly recommended for functional dyspepsia in adults. GERD
usually requires doses ranging from 80–160 mEq ANC. ANCs are dependent on the formulation and quantity of each antacid.
Doses are therefore individual to each preparation. Because ANCs are not provided in Canadian labelling information or product
monographs, antacid doses are often based on manufacturers' recommendations. The most common dose is 10–20 mL or 2–4
tablets after meals and at bedtime, as needed. Doses used in GERD are higher, e.g., 30 mL 1 hour after meals and at bedtime.
Antacids are available in a variety of formulations. If the patient can tolerate the taste, suspensions are preferred over solid
dosage forms since suspensions have a greater ANC (owing to their smaller particle size).22 Some tablet formulations
overcome this by incorporating more active ingredient per dose. Other factors to consider in product selection include
concomitant clinical conditions and cost. Sodium content is important in salt-sensitive patients. Fortunately most products have
a low sodium content.
Although antacids appear to be of limited to no benefit in NUD,23,24 adequate doses (based on ANC of agent) can raise the
gastric pH sufficiently to prevent pepsin activation. Pepsin is an enzyme that begins the digestion of proteins in the stomach,
and contributes to the stomach acid that regurgitates into the esophagus.18 Antacids maintain an increased stomach pH only
while they are in the stomach, so the duration of effect is dependent on the gastric emptying time. After a large meal, the
duration of effect may be 1–3 hours. On an empty stomach it may be less than 1 hour.18 If the dose of antacid neutralizes 90%
of stomach acid the pH rises only one full point, e.g., pH 1.3–2.3.22 Despite the lack of evidence, many clinicians feel that
antacids may resolve some dyspeptic symptoms (e.g., heartburn) related to the presence of acid in the stomach.22 The LES
pressure may also increase with the use of antacids, likely due to increased gastric pH.18 Placebo-controlled trials provide
limited data to support the role of antacids.18
Sodium bicarbonate is suitable only for occasional use because of its high sodium content. It should be avoided in hypertension,
heart failure, renal dysfunction, edema, cirrhosis, pregnancy and other situations where excess sodium intake may be harmful.
Adverse effects include flatulence, belching and abdominal distention. Sodium bicarbonate can also cause metabolic alkalosis,
which may become significant in patients with renal dysfunction or with high doses or prolonged use.
Calcium carbonate is generally the preferred agent in patients with compromised renal function as these patients often have
hypocalcemia and hyperphosphatemia. Patients with compromised renal function are predisposed to developing the milk-alkali
syndrome. This rare syndrome refers to the development of hypercalcemia, metabolic alkalosis and renal insufficiency with oral
intake of more than 2–2.5 g/day of elemental calcium with absorbable alkali. This can result from ingesting calcium as an
antacid (e.g., calcium carbonate) or from the combination of other antacids with calcium from another source such as milk.
Symptoms include nausea, vomiting, weakness and altered mental status. Chronic ingestion of calcium carbonate may cause
hypophosphatemia in predisposed patients; e.g., those with poor dietary intake of phosphates, such as malnourished alcoholics.
Characteristic features of hypophosphatemia include muscle weakness, tiredness and, in its most severe form, breathing
difficulties and heart failure.
Magnesium-based antacids should be avoided in renal failure and limited in the elderly due to the risk of hypermagnesemia.
Signs of magnesium toxicity include nausea and vomiting, flushing, drowsiness and muscle weakness.
Alginic acid acts by physical means and tends to form a layer on top of the gastric contents. The rationale for its action is to be
preferentially refluxed into the esophagus over other gastric contents, thereby decreasing esophageal exposure to acid and bile.
Evidence of this agent's ability to prevent or reverse esophageal injury is lacking. In short-term trials, the combination of alginic
acid with an antacid has not produced a therapeutic advantage over antacid alone.25
See Prenatal and Postpartum Care and Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions.
Further investigation is required for patients with symptoms that persist for >2 weeks, in those with worsening symptoms, when
symptoms are incompletely relieved by antacids, H2RAs and PPIs, and when symptoms recur a number of times per year. Due to the
variability of GERD and dyspeptic symptomologies, clinical judgment is required in conducting follow-up care. This should be based
on the individual patient's symptoms and response to treatments. Follow up on days 2 and 7 of therapy would be reasonable to
ensure that the medication is effective and that the patient is experiencing no adverse side effects. Patients should monitor their
symptoms and response to treatments on regular basis, and keep track of factors that may exacerbate their symptoms.

Advise patients on:
Nonpharmacologic interventions
Expected side effects and their management
Seeing a healthcare practitioner if the condition lasts >2 weeks or if alarm features appear.
Algorithms
1
Figure 1: Assessment and Management of Patients with Dyspepsia and GERD
Abbreviations: GERD = gastroesophageal reflux disease; H2RA = histamine type 2 receptor antagonist; PPI = proton pump inhibitor
Drug Table
Table 6: Drug Therapy for GERD and Dyspepsiaa
Class Drug Dosage Adverse Effects Drug Comments Costb
Interactions
Antacids alginic acid/antacid Alginates Constipation All antacids are Available in $

combinations (sodium common with liquid expected to combination
Gaviscon, generics salt)/aluminum formulation. decrease the with
hydroxide liquid: Hypophosphatemia absorption of aluminum,
Adults: 10–20 has occurred with fluoroquinolone magnesium
mL PC and HS prolonged use or and and calcium
PRN po, followed high doses. Long- tetracycline antacids.
by a glass of term use in antibiotics, Aluminum-
water endstage renal digoxin, iron containing
Alginic disease can cause and isoniazid. antacids
acid/magnesium dementia and They may also should not be
carbonate osteomalacia. decrease used in
tablets: serum infants.
Adults: 2–4 concentrations
tablets (chewed) of ASA but only
PC and HS PRN, when large
followed by a doses of ASA
glass of water are used.
Interactions
Antacids aluminum hydroxide Adults: 500– Constipation All antacids are Avoid use in $$
Alugel, Amphogel, 1800 mg, 2–6 common with liquid expected to patients prone
others times daily po, formulation. decrease the to
between meals Hypophosphatemia absorption of constipation
and HS PRN has occurred with fluoroquinolone or bowel
prolonged use or and obstruction.
high doses. Long- tetracycline Avoid long-
term use in antibiotics, term use in
endstage renal digoxin, iron those with
disease can cause and isoniazid. renal disease.
dementia and They may also Aluminum-
osteomalacia. decrease containing
serum antacids
concentrations should not be
of ASA but only used in
when large infants.
doses of ASA
are used.
Antacids aluminum Adults: 30 mL 1 Diarrhea. Long- All antacids are Avoid high $$
hydroxide/magnesium h PC and HS term use in end- expected to doses or
hydroxide PRN po stage renal disease decrease the prolonged use
combinations may cause absorption of in those with
Diovol, others osteomalacia and fluoroquinolone renal
dementia. May and dysfunction.
cause tetracycline Constipating
hypermagnesemia antibiotics, effect of
in those with renal digoxin, iron aluminum is
dysfunction. and isoniazid. meant to
They may also offset the
decrease diarrhea-
serum producing
concentrations action of
of ASA but only magnesium,
when large but in most
doses of ASA patients
are used. diarrhea
predominates.
Aluminum-
containing
antacids
should not be
used in
infants.
Antacids calcium carbonate Adults: 500– Constipation, All antacids are Stimulates $
Tums, others 1500 mg per day belching, expected to gastrin
in divided doses flatulence. In high decrease the release,
PRN po doses can cause absorption of thereby
milk-alkali fluoroquinolone increasing
syndrome or and acid
hypercalcemia. tetracycline production.
antibiotics, Up to 10%
digoxin, iron systemic
and isoniazid. absorption.
They may also Calcium
decrease carbonate 500
serum mg =
concentrations elemental
of ASA but only calcium 200
when large mg.
doses of ASA
are used.
Interactions
Antacids magnesium salts Adults and Diarrhea common. All antacids are Available as $
Milk of Magnesia, children >12 y: May cause expected to hydroxide,
generics 650–1300 mg hypermagnesemia decrease the carbonate and
per day, in 4 in those with renal absorption of trisilicate
divided doses dysfunction. Renal fluoroquinolone salts. Avoid
PRN po stones have been and use in renal
reported with the tetracycline failure.
trisilicate salt. antibiotics,
digoxin, iron
and isoniazid.
They may also
decrease
serum
concentrations
of ASA but only
when large
doses of ASA
are used.
H2-receptor famotidine Adults and Headache and Concurrent Patients $$$

Antagonists Pepcid AC, Pepcid AC children >12 y: dizziness. administration should be
Maximum Strength, 10–20 mg BID of antacid of investigated
generics PRN po medium to high further if
Maximum: 40 potency (75 symptoms get
mg per day mEq) is not worse or
For prevention of recommended. continue after
acid-related Do not take 2 wk of
symptoms antacids within treatment.
associated with 0.5–1 h of H2-
the consumption receptor
of food and/or antagonist
beverage, take ingestion.
10–15 min AC May decrease
bioavailability
of
ketoconazole.
H2-receptor ranitidine Adults and Headache, nausea, Concurrent Patients $$$

Antagonists Zantac, Zantac children >16 y: vomiting and administration should be
Maximun Strength 75–150 mg BID diarrhea. of antacid of investigated
Non-Prescription, PRN po medium to high further if
Ranitidine, other Maximum: 300 potency (75 symptoms get
generics mg per day mEq) is not worse or
For prevention of recommended. continue after
acid-related Do not take 2 wk of
symptoms antacids within treatment.
associated with 0.5–1 h of H2-
the consumption receptor
of food and/or antagonist
beverage, take ingestion.
30–60 min AC May decrease
bioavailability
of
ketoconazole.
a For more information on pharmacologic therapy for GERD, consult the Compendium of Therapeutic Choices: Gastroesophageal Reflux
Disease.
b
Cost of 30-day supply, includes drug cost only.
Legend: $ <$5 $$ $5–10 $$$ $10–15
Suggested Readings
Armstrong D, Marshall JK, Chiba N et al. Canadian Consensus Conference on the management of gastroesophageal reflux disease
in adults–update 2004. Can J Gastroenterol 2005;19:15-35.
Kahrilas PJ. Clinical practice. Gastroesophageal reflux disease. N Engl J Med 2008;359:1700-7.
Lacy BE, Talley NJ, Locke GR et al. Review article: current treatment options and management of functional dyspepsia. Aliment
Pharmacol Ther 2012;36:3-15.
Vakil N, van Zanten SV, Kahrilas P et al. The Montreal definition and classification of gastroesophageal reflux disease: a global
evidence-based consensus. Am J Gastroenterol 2006;101:1900-20.
References
1. Talley NJ, Ford AC. Functional dyspepsia. N Engl J Med 2015;373:1853-63.

2. Vakil N, van Zanten SV, Kahrilas P et al. The Montreal definition and classification of gastroesophageal reflux disease: a
global evidence-based consensus. Am J Gastroenterol 2006;101:1900-20.
3. Thomson AB, Barkun AN, Armstrong D et al. The prevalence of clinically significant endoscopic findings in primary care
patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment-Prompt Endoscopy (CADET-PE)
study. Aliment Pharmacol Ther 2003;17:1481-91.
4. El-Serag HB, Talley NJ. Systematic review: the prevalence and clinical course of functional dyspepsia. Aliment Pharmacol
Ther 2004;19:643-54.
5. Kahrilas PJ, Shaheen NJ, Vaezi MF et al. American Gastroenterological Association Institute technical review on the
management of gastroesophageal reflux disease. Gastroenterology 2008;135:1392-413.
6. Storr M, Meining A, Allescher HD. Pathophysiology and pharmacological treatment of gastroesophageal reflux disease. Dig
Dis 2000;18:93-102.
7. Orlando RC. The pathogenesis of gastroesophageal reflux disease: the relationship between epithelial defense, dysmotility,
and acid exposure. Am J Gastroenterol 1997;92:3S-5S.
8. Kahrilas PJ. Clinical practice. Gastroesophageal reflux disease. N Engl J Med 2008;359:1700-7.
9. Spechler SJ. GERD and its complications. Mt Sinai J Med 2000;67:106-11.
10. Devault KR. Review article: the role of acid suppression in patients with non-erosive reflux disease or functional heartburn.
Aliment Pharmacol Ther 2006;23:33-9.
11. Piessevaux H, De Winter B, Louis E et al. Dyspeptic symptoms in the general population: a factor and cluster analysis of
symptom groupings. Neurogastroenterol Motil 2009;21:378-88.
12. de Vries DR, van Herwaarden MA, Smout AJ et al. Gastroesophageal pressure gradients in gastroesophageal reflux disease:
relations with hiatal hernia, body mass index, and esophageal acid exposure. Am J Gastroenterol 2008;103:1349-54.
13. Pandolfino JE, Shi G, Trueworthy B et al. Esophagogastric junction opening during relaxation distinguishes nonhernia reflux
patients, hernia patients and normal subjects. Gastroenterology 2003;125:1018-24.
14. Shaheen NJ, Crosby MA, Bozymski EM et al. Is there publication bias in the reporting of cancer risk in Barrett's esophagus?
15. Hvid-Jensen F, Pedersen L, Drewes AM et al. Incidence of adenocarcinoma among patients with Barrett's esophagus. N Engl
J Med 2011;365:1375-83.
16. van Marrewijk CJ, Mujakovic S, Fransen GA et al. Effect and cost-effectiveness of step-up versus step-down treatment with
antacids, H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a
primary-care-based randomised controlled trial. Lancet 2009;373:215-25.
17. Veldhuyzen van Zanten SJ, Flook N, Chiba N et al. An evidence-based approach to the management of uninvestigated
dyspepsia in the era of Helicobacter pylori. Canadian Dyspepsia Working Group. CMAJ 2000;162:S3-23.
18. Kitchen LI, Castell DO. Rationale and efficacy of conservative therapy for gastroesophageal reflux disease. Arch Intern Med
1991;151:448-54.
19. Bazaldua OV, Schneider FD. Evaluation and management of dyspepsia. Am Fam Physician 1999;60:1773-84.
20. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs
1999;57:855-70.
21. DeVault KR. Overview of medical therapy for gastroesophageal reflux disease. Gastroenterol Clin North Am 1999;28:831-45.
22. McEvoy GK, American Society of Health-System Pharmacists. AHFS drug information 2010. Bethesda: American Society of
Health-System Pharmacists; 2010.
23. Fisher RS, Parkman HP. Management of nonulcer dyspepsia. N Engl J Med 1998;339:1376-81.
24. Holtmann G, Talley NJ. Functional dyspepsia. Current treatment recommendations. Drugs 1993;45:918-30.
25. Lanza FL, Sibley CM. Role of antacids in the management of disorders of the upper gastrointestinal tract. Review of clinical
experience 1975-1985. Am J Gastroenterol 1987;82:1223-41.

Dyspepsia
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients. Once printed there is no
quarantee the information is up-to-date. [Printed on: 08-02-2017 12:11 PM]
Gastrointestinal Gas
Co Q. D. Pham, BSc, BA, BScPharm, ACPR, Pharm D

Introduction
Intestinal gas represents a normal and common biological process in healthy adults. Excess gas in the
digestive tract can be found in the esophagus, stomach, small intestine and large intestine. These gases are
removed via flatulence or eructation.1,2 Common terms used to refer to gastrointestinal (GI) gas or its
expulsion to the outside world include abdominal gas, gas, intestinal gas, flatus, farting, passing wind,
bloating, belching, burping, abdominal pain, cramping, abdominal distention and abdominal discomfort.
Pathophysiology
The passage of gas is a normal daily process.1 The gut typically contains <200 mL of gas, while daily gas
expulsion averages 500–700 mL.2,3 The main complaints about intestinal gas include excessive eructation,
distention (bloating) and excessive flatus (Table 1).1,2,4 There is poor correlation between the volume of gas
in the digestive tract and actual symptoms.5
Eructation: Eructation (belching) results from swallowed air into the GI tract (aerophagia) or the ingestion of
carbonated beverages. Aerophagia is a normal process occurring while people eat and drink. However,
many individuals will swallow air unconsciously while smoking, when anxious or when trying to induce
belching. Other causes of aerophagia include excessive salivation, respiratory disorders, not chewing food
thoroughly, GI disorders (dyspepsia, acid-reflux), some medications, gum chewing, ill-fitted dental apparatus
and sensations of nausea. Eructation may also be a sign of more serious underlying GI disorders such as
peptic ulcer disease, gastroparesis or gastroesophageal reflux disease (GERD).6,7,8 Normally, most of the air
swallowed is eructated to prevent excess accumulation of gas in the GI tract.2,6,8
Abdominal Discomfort: Abdominal discomfort (bloating, cramping or pain) is often attributed to excess
intestinal gas, although evidence does not always link it to these complaints. Abdominal discomfort may
present in isolation or may occur as a result of underlying GI disorders: functional GI disorders (e.g., irritable
bowel syndrome, dyspepsia), inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), GERD,
altered GI motility or colon cancer. Other conditions such as eating disorders (e.g., bulimia, anorexia) may
also be associated with symptoms of abdominal discomfort. Some individuals have hypersensitive
intestinal tracts, where minor changes in gas volume may result in abdominal discomfort. Thus, the causes
of abdominal discomfort vary and should be assessed thoroughly.2,4
Abdominal pain deserves a careful note, because the region of pain may be confused in many cases with
other medical conditions. Right-sided colonic pain may resemble gallstones or appendicitis, and left-sided
colonic pain may be misdiagnosed in heart disease. Severe abdominal pain should be investigated promptly
(see alarm symptoms in Patient Assessment).4,6
Flatulence: Gas is always present in the GI tract. The average person passes gas 10–25 times daily. The
elderly may pass gas more frequently, but this is not well defined. Although there is considerable variability
in the frequency and quantity of flatulence, passing gas more than 25 times a day may be considered
excessive. Flatus results from the normal metabolic by-products of nonabsorbable foods digested and
fermented by intestinal bacteria. Very little is due to aerophagia. The small intestine is unable to digest and
absorb certain carbohydrates (e.g., fibre and nonabsorbable carbohydrates such as raffinose, stachyose and
verbascose) found in foods. As a result the undigested food passes to the large intestine, where normal
bacterial flora break down the food. The primary components of flatus are 5 gases: nitrogen, hydrogen,
carbon dioxide, methane and oxygen. The odour of flatus stems from trace gases: skatoles, indoles and
sulfur compounds. The frequency and quantity of flatus are related to an individual's diet and intestinal
flora.1,2,4
Common dietary sources of intestinal gas include lactose, fibre and other nonabsorbable carbohydrates. A
deficiency of lactase in the GI tract permits lactose to reach the colon where it is metabolized into fatty
acids and 2 gases: hydrogen and carbon dioxide.1,2 Lactase deficiency can be congenital or secondarily
acquired. The acquired disorder is more commonly seen in older children and adults, and may be due to
celiac disease, infectious gastroenteritis or giardiasis. Congenital causes of lactase deficiency are due to a
mutation in the gene that is responsible for producing lactase (absent from birth) and are more prevalent in
Asians than Caucasians.
Table 1: Causes of Gastrointestinal Gas

Symptoms Causes
Eructation (belching) Aerophagia (air swallowing): eating quickly, excessive salivation, gum
chewing, mal-fitted dental apparatus, nausea, respiratory disorders,
smoking
Consumption of carbonated beverages
Abdominal discomfort Aerophagia

(bloating, cramping, Cancer
pain)
Eating disorders (anorexia, binge eating, bulimia, compulsive eating)
GI disorders: functional GI disorders (irritable bowel syndrome,
dyspepsia), inflammatory bowel disease (Crohn's disease, ulcerative
colitis), GI motility disorders
Flatus Celiac disease/tropical sprue

Dietary consumption: beans, complex carbohydrates, dairy, vegetables
Disaccharidase deficiency
Pancreatic insufficiency
Goals of Therapy
Educate patients about the normal aspects of GI gas
Relieve symptoms (belching, pain, bloating, flatulence)
Educate patients regarding preventive measures
Patient Assessment
The symptoms of gas are variable and subjective.2,3,4,6 An important first step is to review the patient
history. Patients with eructation should have a history of aerophagia, whereas flatus or abdominal
discomfort may be associated with timing, quantity and type of foods consumed, bowel habits or other
underlying medical conditions. The history should also elicit any relevant medical conditions (respiratory
disorders, GI disorders such as celiac disease, lactose intolerance or gastroparesis).
Patients with recurrent symptoms of abdominal fullness, distention or bloating relieved by defecation may
have features of underlying irritable bowel syndrome (see Irritable Bowel Syndrome). Weight loss associated
with GI gas may suggest a malabsorption syndrome.
Be vigilant for alarm symptoms in the history, which may include weight loss, blood in stool or vomit,
moderate to severe abdominal pain or swelling, sudden changes in bowel habits, nausea or vomiting, or
fever and chills. Investigate patients promptly if they present with any alarm symptoms.4
In general, testing for GI gas is not required. However, in some severe cases testing for carbohydrate
intolerance, bacterial overgrowth, bacterial cultures or endoscopic examinations may be warranted. Figure 1
outlines a general approach to assessing patients with GI gas.
The majority of patients have symptoms that do not require any treatment, but many may seek advice in
selecting treatments for more excessive or intolerable symptoms. Typically, changes in diet and lifestyle
allow for quick corrections in the symptoms of gas.4
Eructation: Recognize the history and activities of aerophagia. Some patients gulp air with each belch. This
is often associated with multiple small belches over seconds. Educating the patient to stop gulping air with
each belch or instructing a forced cessation of belching should relieve this.3 Adjusting poorly fitting dental
apparatus or decreasing excess salivation by reducing gum chewing, cigar chomping or cigarette smoking
can help improve eructation. Also, reducing ingestion of gas-producing or gas-releasing substances (e.g.,
carbonated beverages, sodium bicarbonate) may be helpful. Encourage patients to eat meals slowly to
decrease the likelihood of gulping air when swallowing.2,6,7 Abdominal breathing exercises may also be
considered.8
GI Discomfort: The feeling of bloating with the desire to belch can simply be due to overeating. Very large
meals ingested in the late evening may induce symptoms; eating less and earlier in the day may reduce
them. Abdominal cramping may arise from a number of dietary and pharmaceutical sources, such as
osmotic laxatives.2,4
Flatulence: Eating smaller more frequent meals throughout the day may help decrease symptoms. A proper
exercise program may also help improve and maintain the function of the GI system and reduce gas
production.1,2,4
Dietary therapy with foods low in fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) may
be an option in the management of patients with functional gut symptoms.9 FODMAPs include fructans,
fructose, galacto-oligosaccharides, lactose, mannitol and sorbitol. Foods rich in FODMAPs include apples,
artichokes, cauliflower, garlic, honey, legumes, mango, milk, mushrooms, onions, pears, rye, stone fruits,
sugar-free mints/gums, watermelon and wheat.10,11
Ailments—Gastrointestinal Products: Antacid, Antiflatulent and Antireflux; Nutrition Products: Lactose
Digestants.
Evidence-based pharmacotherapy for GI gas is limited and no consensus guidelines for the management of
this condition exist. Currently there is no evidence-based therapy for aerophagia; the proper approach and
treatment for eructation is unclear. It is important to identify the underlying causes of eructation and correct
them whenever possible. Otherwise, further medical evaluation for GI disorders such as GERD should be
considered.
Information on selected therapies for GI gas can be found in Table 2.
Activated charcoal tablets have not demonstrated efficacy in reducing symptoms of intestinal gas and
should not be recommended.4,12 External charcoal devices for reducing odour can be effective in binding
sulfur gases.13 These devices exist as pads, cushions or briefs and may be useful depending on patient
preference.
Alpha-D-galactosidase is effective in reducing symptoms of flatus and abdominal discomfort associated

with the consumption of nonabsorbable carbohydrates.14 Enzyme products should not be put on hot foods
(too hot to eat or during cooking) as heat renders the enzyme inactive. Instruct patients to place the liquid
enzyme on the first spoonful of food.
The use of antibiotics in the general treatment of gas is not required. However, if bacterial overgrowth is
suspected, antibiotics may be required.15
Baclofen is a muscle relaxant that has been studied in the reduction of eructation. It may reduce reflux, air
swallowing and belching.16 More research is needed to confirm these findings. Baclofen has CNS side-
effects that may limit longer term use in eructation.
Bismuth subsalicylate is capable of binding a considerable amount of sulfide gas. Therefore, it may be very
effective in the short-term relief of intestinal gas. However, to avoid salicylate toxicity, do not recommend
bismuth for long-term use (>3–4 weeks) or at high doses (>150 mg/kg).17,18
Lactase supplementation taken with or prior to ingestion of lactose products can prevent flatulence in
patients with lactase deficiency. The amount of supplementation required is dependent on the amount of
lactose ingested. Dairy products with lactose should still be consumed in moderation as large doses of
lactose will not be completely broken down by the lactase supplement. Patients with suspected lactose
malabsorption require further investigation for proper diagnosis.
Laxatives may have an important role in reducing symptoms of intestinal gas, notably those associated with
constipation (see Constipation).
Probiotics are live microorganisms that confer a health benefit. Although not all commonly used probiotics
have been adequately studied in randomized-controlled trials, some data have demonstrated a reduction in
both short- and long-term symptoms of abdominal distention, bloating, and gas. Commercially available
products are not always consistent in the quantity and type of bacterial species combined.19,20,21,22,23
Simethicone acts by preventing bubbling of liquids in the stomach and does not appear to be absorbed from
the GI tract. However, data do not show a clear benefit in the reduction of symptoms from intestinal gas.
Despite this fact, it is generally used for treatment of flatulence and abdominal bloating. Simethicone in
combination with loperamide may be effective in reducing abdominal bloating and flatus associated with
acute diarrhea.24
Information on selected therapies for GI gas can be found in Table 2. Other specific pharmacotherapy
options might be indicated if there is underlying pathology affecting GI motility, functional GI disorders
(irritable bowel disease, inflammatory bowel disease) or infection.
Peppermint probably acts by reducing lower esophageal sphincter pressure, theoretically making it
easier to pass gas from the stomach into the esophagus.25 This pressure reduction potentially increases
the likelihood of GERD.
Garlic and ginger are other alternative products promoted for treatment of intestinal gas. However, there
is insufficient evidence to recommend their use.
Investigate patients further if they experience alarm symptoms or if their symptoms persist for more than
1–2 weeks despite pharmacotherapy.
Exclusion diets (e.g., diets free of lactose or nonabsorbable carbohydrates) should be monitored for
effective resolution of symptoms. If symptoms persist, both diet and other sources of the triggers (e.g.,
lactose in medications and herbals) should be more rigorously evaluated.
Functional GI conditions presenting with symptoms of abdominal distention (bloating), pain and flatus may
be chronic or intermittent and may only be partially managed with pharmacotherapy. It is important to be
positive and reassure patients with functional GI disorders that these symptoms are not detrimental to their
health.
Algorithms
Figure 1: Assessment of Patients with Gastrointestinal Gas
Drug Table
Table 2: Drug Therapy for Intestinal Gas and Cramps
Class Drug Dosage Adverse Effects Costa
Adsorbents bismuth 524 mg QID po Constipation, diarrhea, $

subsalicylate (maximum 8 nausea, tongue
Pepto- doses/day) discolouration, grayish-
Bismol, black stool, vomiting
generics
Antiflatulents simethicone 80–160 mg per None reported $

Ovol, Gas X, meal po
others
Enzymes alpha-D- 150–450 GaIU po Rare allergic reactions $

galactosidase with the first bite (rash, pruritus)
Beano of food (300–1200
GaIU/day)
Legend: $ <$1
Suggested Readings
Bailey J, Carter NJ, Neher JO. FPIN's Clinical Inquiries: Effective management of flatulence. Am Fam
Physician 2009;79:1098-100.
Kessing BF, Bredenoord AJ, Smout AJ. The pathophysiology, diagnosis and treatment of excessive belching
symptoms. Am J Gastroenterol 2014;109:1196-203.
Lacy BE, Gabbard SL, Crowell MD. Pathophysiology, evaluation, and treatment of bloating: hope, hype, or hot
air? Gastroenterol Hepatol (N Y) 2011;7:729-39.
References
1. Serra J, Azpiroz F, Malagelada JR. Intestinal gas dynamics and tolerance in humans.
2. Azpiroz F. Intestinal gas dynamics: mechanisms and clinical relevance. Gut 2005;54:893-5.
3. Bharucha AE. Gas-related complaints. In: The Merck manual of diagnosis and therapy. Rahway: Merck
Sharp and Dohme; 2007.
4. Bailey J, Carter NJ, Neher JO. FPIN's Clinical Inquiries: Effective management of flatulence. Am Fam
Physician 2009;79:1098-100.
5. Morken MH, Berstad AE, Nysaeter G et al. Intestinal gas in plain abdominal radiographs does not
correlate with symptoms after lactulose challenge. Eur J Gastroenterol Hepatol 2007;19:589-93.
6. Bredenoord AJ, Smout AJ. Physiologic and pathologic belching. Clin Gastroenterol Hepatol
2007;5:772-5.
7. Lin M, Triadafilopoulos G. Belching: dyspepsia or gastroesophageal reflux disease? Am J
Gastroenterol 2003;98:2139-45.
8. Kessing BF, Bredenoord AJ, Smout AJ. The pathophysiology, diagnosis and treatment of excessive
belching symptoms. Am J Gastroenterol 2014;109:1196-203.
9. Gibson PR, Shepherd SJ. Evidence-based dietary management of functional gastrointestinal
symptoms: The FODMAP approach. J Gastroenterol Hepatol 2010;25:252-8.
10. Barrett JS, Gibson PR. Fermentable oligosaccharides, disaccharides, monosaccharides and polyols
(FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals? Therap Adv
11. Azpiroz F, Hernandez C, Guyonnet D et al. Effect of a low-flatulogenic diet in patients with flatulence
and functional digestive symptoms. Neurogastroenterol Motil 2014;26:779-85.
12. Suarez FL, Furne J, Springfield J et al. Failure of activated charcoal to reduce the release of gases
produced by the colonic flora. Am J Gastroenterol 1999;94:208-12.
13. Ohge H, Furne JK, Springfield J et al. Effectiveness of devices purported to reduce flatus odor. Am J
14. Di Stefano M, Miceli E, Gotti S et al. The effect of oral alpha-galactosidase on intestinal gas
production and gas-related symptoms. Dig Dis Sci 2007;52:78-83.
15. Sharara AI, Aoun E, Abdul-Baki H et al. A randomized double-blind placebo-controlled trial of
rifaximin in patients with abdominal bloating and flatulence. Am J Gastroenterol 2006;101:326-33.
16. Blondeau K, Boecxstaens V, Rommel N et al. Baclofen improves symptoms and reduces
postprandial flow events in patients with rumination and supragastric belching. Clin Gastroenterol
Hepatol 2012;10:379-84.
17. Suarez FL, Furne JK, Springfield J et al. Bismuth subsalicylate markedly decreases hydrogen sulfide
release in the human colon. Gastroenterology 1998;114:923-9.
18. Chyka PA, Erdman AR, Christianson G et al. Salicylate poisoning: an evidence-based consensus
guideline for out-of-hospital management. Clin Toxicol (Phila) 2007;45:95-131.
19. Kim HJ, Vazquez Roque MI, Camilleri M et al. A randomized controlled trial of a probiotic
combination VSL#3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil
2005;17:687-96.
20. Bittner AC, Croffut RM, Stranahan MC et al. Prescript-assist probiotic-prebiotic treatment for irritable
bowel syndrome: an open-label, partially controlled, 1-year extension of a previously published
controlled clinical trial. Clin Ther 2007;29:1153-60.
21. Di Stefano M, Miceli E, Armellini E et al. Probiotics and functional abdominal bloating. J Clin
Gastroenterol 2004;38:S102-3.
22. Kajander K, Hatakka K, Poussa T et al. A probiotic mixture alleviates symptoms in irritable bowel
syndrome patients: a controlled 6-month intervention. Aliment Pharmacol Ther 2005;22:387-94.
23. Lacy BE, Gabbard SL, Crowell MD. Pathophysiology, evaluation, and treatment of bloating: hope,
hype, or hot air? Gastroenterol Hepatol (N Y) 2011;7:729-39.
24. Hanauer SB, DuPont HL, Cooper KM et al. Randomized, double-blind, placebo-controlled clinical trial
of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of
acute diarrhea with gas-related abdominal discomfort. Curr Med Res Opin 2007;23:1033-43.
25. Suarez FL, Springfield J, Levitt MD. Identification of gases responsible for the odour of human flatus
and evaluation of a device purported to reduce this odour. Gut 1998;43:100-4.

Gastrointestinal Gas
Gastrointestinal Gas—What You Need to Know
What causes GI gas symptoms?
Excess eructation (belching) is often caused by swallowing air or eating things that release gas. If you have gas in your
abdomen, it can cause cramps. Here are some hints to help prevent gas and reduce belching:
Do not chew gum, chomp on cigars or smoke cigarettes.

Do not drink carbonated beverages such as colas.
Eat your meals slowly.
If you often feel abdominal discomfort (bloating or pain), avoid eating large meals, especially late in the day.
If your gas and abdominal discomfort seem to be related to certain foods, consider changing your diet or avoiding foods that
cause these symptoms. Alternatively, there may be a medication that could help you.
When should you see a health-care provider?
See a health-care provider if:
Your symptoms last for more than 1–2 weeks.

Your symptoms are very painful and come on suddenly.
You lose weight without trying.
Your stools (bowel movements) contain blood or dramatically change in colour, e.g., pale whitish or black, tar-
like stools.
You develop fever or chills.
Your stomach or intestines feel unwell.
What can you do?
It may help to change what you eat—you may need to avoid some foods or modify your diet. Exercise can improve and
maintain the stomach and intestinal function. Check with a health-care provider before you make changes to your diet and
exercise routines.
Itching
Irritation
Hemorrhoids Burning
Swelling
Joyce Chan, BScPhm, MSc, PharmD Small amount of bright red blood
CPhA acknowledges the contribution of Patricia Carruthers-Czyzewski as a previous author of this chapter.
Pathophysiology
Hemorrhoids are a normal anatomic feature of the anal canal and contribute to continence. Commonly
referred to as cushions, they consist of connective tissue, an arteriovenous plexus and suspensory smooth
muscle. The existence of hemorrhoidal cushions alone does not constitute disease. Once symptoms appear
(typically bleeding, itch, protrusion or pain) due to swelling and/or prolapse, then hemorrhoids are diseased.1
Hemorrhoids can be classified as internal, external or mixed hemorrhoids (Figure 1). Internal hemorrhoids
originate above the dentate/pectinate/anorectal line and may be further classified into 4 stages (see below).
Internal hemorrhoids should not cause pain unless complications develop, since this area has no nerve fibres.
External hemorrhoids originate below the dentate line and can cause pain, since this area is well innervated by
pain fibres. The term “mixed hemorrhoids” is used when internal and external hemorrhoids coexist.2,3
Figure 1: Classification of Hemorrhoids
Internal hemorrhoids can be classified symptomatically according to their degree of formation. First-degree
hemorrhoids swell in the anal cushion due to straining and are usually painless. During the second stage, a
small part of the anal mucosa or cushion may protrude at the anus during defecation. After the bowel
movement, the hemorrhoid spontaneously returns to its normal position. Third-degree hemorrhoids remain in
the prolapsed position after defecation, but may be re-placed manually within the anus. Fourth-degree
hemorrhoids cannot be re-placed after a bowel movement, and thus create a permanent bulge at the anus.
This condition is quite painful, and it is usually at this stage that individuals should consult their physician.
Fourth-degree hemorrhoids are at risk of thrombosis and gangrene.4
Hemorrhoids are common. Fifty-eight to 86% of individuals will have symptomatic hemorrhoids at some point
in their lives.5,6 A US survey showed a prevalence of 4.4% in the general population. Hemorrhoids occur
equally in both sexes, peaking between the ages of 45 and 65, and declining thereafter.7 The incidence of
hemorrhoids may be overestimated. Some studies have indicated that when patients complain of
hemorrhoids, only 50% actually have simple hemorrhoids; other problems include thrombosed hemorrhoids in
approximately 18.5% of patients with anal complaints, fissures in 8% and miscellaneous problems in 23%.8
Many factors may be associated with the development of hemorrhoids: constipation, diarrhea, pregnancy,
advancing age and possibly type of work and physical exertion.8,9,10 When the individual tries to pass small,
firm stools, the intrarectal pressure rises, blocking the venous return from the anal canal and leading to more
straining. The shearing action of the fecal mass passing over the area causes a loosening of the underlying
connective tissue. Diarrhea, either acute or chronic, can also cause hemorrhoids due to futile and protracted
straining. Heredity is not an important factor. The only connection between heredity and hemorrhoids is the
similarity of diet and personal habits in members of the same family.9
Pregnancy is believed to precipitate the onset of hemorrhoids in susceptible women. The woman who
experiences hemorrhoids in the last few months of pregnancy may have become symptomatic due to
increased abdominal pressure, allowing already existing hemorrhoids to present themselves. Other
possibilities are that during pregnancy there may be a softening of the elastic tissue that supports anal
cushions or that the woman may be more constipated. In many cases, these hemorrhoids resolve after
parturition.11
Other possible causes of hemorrhoids include increased abdominal pressure due to heavy lifting and
prolonged standing or sitting. Prolonged periods of time on the toilet and chronic straining can increase the
risk of hemorrhoids; in this position, the perineum is relaxed and the anal cushions are unsupported.9
Evidence of any of these risk factors as primary causes of hemorrhoids is nonexistent. Rather, it is probable
that each can worsen asymptomatic hemorrhoids that are already present.9
Hemorrhoids are found primarily in populations consuming a diet high in white flour, sugar and fibre-depleted
carbohydrate foods. However, there is no association between fibre intake and the prevalence of hemorrhoids.
There is no evidence that spicy foods worsen the irritation and pruritus of hemorrhoids.12
Goals of Therapy
Relieve symptoms
Promote good bowel habits and anal hygiene
Patient Assessment
For some patients, the first symptom is a painful mass at the anus lasting several days to weeks (thrombosed
hemorrhoid), sometimes accompanied by the sudden relief of pain following rupture of the skin overlying the
thrombus and bleeding. Other symptoms include itching, swelling and burning. Swelling is probably the main
cause of pruritus. Fecal soiling of underwear often occurs. Prolapse often coincides with the beginning of a
troublesome amount of discharge as a result of increased mucus production. The degree of discomfort
experienced by the patient is dependent on the type of hemorrhoids and their severity. Internal hemorrhoids
lack nerves and are painless. When hemorrhoids bleed, the blood is usually bright red and seen on the outer
part of stools after defecation. The patient does not usually bleed at other times.
Healthcare practitioners should base the diagnosis of hemorrhoids on the patient's history and results of a
physical exam. If bleeding exists, its source would often require confirmation by endoscopy.13 Since many
patients delay seeking help for hemorrhoids until symptoms have become unbearable, referral to a qualified
healthcare practitioner is often required.13
Prevention
The most important preventive measure is to avoid constipation (see Constipation). Advise patients not to
remain on the toilet more than 1–2 minutes and to avoid straining.
Fibre supplementation may help improve constipation, pruritus due to fecal soilage and bleeding.14 The
benefit of fibre for irritation and pruritus is less well established than for bleeding.14 Adding fibre to the diet is
usually adequate to relieve symptoms of hemorrhoids in individuals with first- and second-degree
hemorrhoids. When recommending fibre supplementation suggest starting at a low dose and slowly
increasing (up to a total of 20–30 g per day) to minimize problems with bloating and abdominal discomfort.13
Patients should also ensure adequate fluid intake with fibre supplementation.
If these general measures do not relieve hemorrhoidal symptoms, recommend the use of a Sitz bath 3–4
times daily. Sitz baths help relieve irritation and pruritus. Their effectiveness may in part be related to
relaxation of the internal anal sphincter.15 A Sitz bath consists of a tub of warm water (about 46°C) in which
the individual sits for 15 minutes at a time. Plastic Sitz baths may be fitted over the toilet seat rim for greater
convenience.
Any prolapsed hemorrhoids must be replaced using a moistened tissue. After each bowel movement, the
anorectal area should be cleaned with mild soap and water and gently wiped with a wet toilet tissue.
Nonsurgical therapies (e.g., rubber-banding or infrared coagulation) are widely used although there have been
no placebo-controlled trials to establish their efficacy.16 In-office rubber band ligation may result in a lower
need for repeated treatment compared with injection sclerotherapy and infrared coagulation in the
management of first- to third-degree hemorrhoids.17 Surgical hemorrhoidectomy is the most effective
treatment but is associated with the highest complication rates and most postoperative disability. It is
recommended in only a minority of patients (e.g., for treatment failures, for third- and fourth-degree
hemorrhoids and for acute thrombosed hemorrhoids).18 More than 80% of people respond to medical
treatment, rubber-banding placed endoscopically or infrared coagulation; these methods cause less
discomfort and entail less time off work compared with hemorrhoidectomy.2,3
Ailments—Gastrointestinal Products: Hemorrhoids.
Pharmacologic treatments are directed towards relief of symptoms; none are curative. A variety of
hemorrhoidal products are available (see Table 1). There is no good evidence that commercially available
hemorrhoidal products reduce bleeding or prolapse.10 However, they can provide short-term relief of pain,
burning, itch, discomfort and irritation while swelling subsides and healing occurs. Many commercially
available hemorrhoidal products are formulated in a lubricating or emollient base with combinations of 2 or
more active ingredients, including anti-inflammatory agents, astringents, local anesthetics, protectants and
vasoconstrictors.
Local anesthetics are included in some topical hemorrhoidal preparations to relieve pain. If used for less than
7 days, local anesthetics are relatively safe and may relieve pain. Longer duration of use increases the risk of
contact dermatitis. Good evidence of their efficacy is lacking.10 Penetration of intact skin by local anesthetics
is generally poor, but with excessive application to the rectal mucosa, absorption can occur.10 Adverse effects
associated with systemic use of local anesthetics include CNS effects (restlessness, excitement,
nervousness, paresthesias, dizziness, tinnitus, blurred vision, nausea and vomiting, muscle twitching and
tremors, convulsions) and cardiovascular effects (hypotension, bradycardia).10 Products containing local
anesthetics should be used only in the perianal region or the lower anal canal to reduce systemic absorption.
Hydrocortisone is used for temporary relief of anal itch and as an anti-inflammatory agent in the treatment of
hemorrhoids.19 The maximum recommended duration of treatment is 1 week, but up to 14 days may be
appropriate if significant improvement is occurring.20 Hydrocortisone 1% is available in various combinations
with zinc sulfate and/or local anesthetics. Ointments are recommended for external hemorrhoids. For internal
hemorrhoids, the ointment (applied manually using a finger cot) is preferred to using rectal tubes or
suppositories.20
Astringents cause coagulation (clumping) of proteins in the cells of the perianal skin or the lining of the anal
canal. This action promotes dryness of the skin, which in turn helps relieve burning, itching and pain. These
are effective for mild symptoms but if there is significant itching and discharge, a preparation that includes
hydrocortisone can be recommended.
Protectants prevent irritation of the perianal area by forming a physical barrier on the skin. This barrier
reduces irritation, itch, pain and burning by preventing contact of the irritated skin with liquid or stool from the
rectum. Their lubricating effect further protects the skin from irritation. For example, when included in
hemorrhoidal products, petrolatum allows the stool to pass through the rectum more easily and freely,
potentially minimizing further tissue damage.
Hemorrhoidal preparations are available in a variety of dosage forms (e.g., creams, ointments, suppositories
and cleaning pads). Ultimately, the choice of delivery form lies with the consumer. Many people prefer
suppositories, but these products may not be effective because they tend to slip into the rectum and melt,
thus bypassing the anal canal where the medication is needed. To prevent a suppository from slipping into the
rectum, advise patients to avoid inserting it too far up, and to lie down for a few minutes on their side after
insertion. In general, creams and ointments are preferable to suppositories. They are easy to apply and usually
contain the same or similar ingredients.
Hemorrhoidal products for external use should be applied sparingly and not inserted into the rectum. Before
any hemorrhoidal product is applied, the anorectal area should be washed with mild soap and warm water,
rinsed thoroughly and dried gently by patting or blotting with toilet tissue or a soft cloth.
Hemorrhoidal products are not recommended for children under the age of 12 years, unless the child has
been examined.21
Oral analgesics such as acetaminophen may provide relief of mild discomfort or pain. Opioids should not be
recommended as they may cause constipation and worsen the hemorrhoids. Management of constipation
also decreases discomfort during defecation.
Phlebotonic agents such as the bioflavonoids diosmin and hesperidin have demonstrated efficacy in the
treatment of hemorrhoids.6,22 Though the precise mechanism is not known, phlebotonics are associated
with strengthening of vessel walls and increased venous tone. These preparations are considered safe.
Another therapy that is described as helping to reduce hemorrhoids is topical bovine cartilage; the 5%
cream relieves itching and the 2% suppository works as a stool softener.23
Horse chestnut has also been used for symptomatic relief of hemorrhoids. The active ingredients in horse
chestnut appear to be saponins, of which aescin is considered the most important. Aescin appears to
reduce swelling and inflammation.24 Adverse effects include pruritus, nausea, stomach complaints,
bleeding, nephropathy and allergic reactions. There is little evidence to support the topical use of horse
chestnut for hemorrhoids. Horse chestnut and aescin are contraindicated during pregnancy and
breastfeeding or in patients who have bleeding disorders. In addition, it may interact with ASA and other
antithrombotics leading to an increased bleeding risk.23,25
Pregnancy
At present, there are no reproductive safety data available for any of the compounds commonly used for
hemorrhoids. Hemorrhoids in pregnancy should be treated by increasing fibre content in the diet,
administering stool softeners, increasing liquid intake, and training in toilet habits.11 Correcting
constipation and taking Sitz baths are usually helpful in reducing the discomfort from hemorrhoids.
External medications are preferred over those inserted into the rectum because the drugs can be well
absorbed from the rectal mucosa. Products containing local anesthetics and corticosteroids, in the
recommended dosages, can be used during pregnancy with medical supervision.26 Systemic absorption
after excessive use of a topical corticosteroid has been associated with intrauterine growth
retardation.26,27
Assess relief of symptoms such as itching, pain or burning. Check with the patient in 1 week. If there is no
relief within 7 days, if symptoms worsen, or if bleeding, protrusion or seepage occur, reassess and consider
referral to specialist care as symptoms associated with rectal cancer, anal fissure, anal abscess, anal fistula,
perianal hematoma and other diseases may be similar to those produced by hemorrhoids.28

Nonpharmacologic therapy, such as increasing fibre in diet

Management of constipation, if applicable (see Constipation)
Proper use and side effects of chosen medication
When to see a healthcare practitioner.
Drug Table
Table 1: Drug Therapy for Hemorrhoids
Class Drug Dosage Adverse Effects Comments Costa
Anesthetics, dibucaine 0.5–1% Allergic Amide type $$

Local Proctosedyl, ointment/cream; reactions, locally Common
generics 5 mg and systemically; ingredient in
suppository local reactions hemorrhoidal
Use each (burning and products.
morning and itching). Also referred to
evening and as cinchocaine.
after each bowel
movement
Anesthetics, pramoxine 1% ointment; 20 Allergic Exhibits less $

Local Anusol Plus, mg suppository reactions, locally cross-sensitivity
Anugesic HC, Use each and systemically; because it does
generics morning and local reactions not have the
evening and (burning and usual amide or
after each bowel itching). ester structure.
movement Lower incidence
of sensitization.
Generally used
in combination
with
hydrocortisone
and/or zinc.
Anti-infectives framycetin 1% ointment; Local irritation, Used to reduce $$

Proctosedyl, suppositories itching, superimposed
generics Use every sensistivity. bacterial
morning and infection to
evening and alleviate edema,
after each bowel inflammation
movement PRN and pruritus.
Anti- hydrocortisone 0.5% and 1% Mucosal atrophy Should not be $$

inflammatory acetate ointment; 5–10 (more common used for longer
Agents Anusol HC, mg with prolonged than 7 days, but
Anugesic HC, suppositories use). up to 14 days
Proctosedyl, Use every may be
generics morning and appropriate if
evening and significant
after each bowel improvement is
movement PRN occurring.
Astringents hamamelis 50% gel; No significant Generally used $$

Preparation H- available as adverse effects. in combination
PE Gel pads or wipes with
Use up to 6 phenylephrine.
times daily after
each bowel
movement PRN
Astringents zinc sulfate 0.5% No significant Common $

Anusol, ointment/cream; adverse effects. ingredient in
Anusol Plus, 10 mg hemorrhoidal
Anusol HC, suppository products.
Anugesic HC, Use up to 6
generics times daily after
each bowel
movement PRN
Phlebotonics diosmin 600 mg TID po × Abdominal pain, May help reduce $$$
Hemovel 4 days then 600 diarrhea, pain, edema and
mg BID po × 3 headache, bleeding and
days nausea. overall
symptom
duration.
Protectants glycerin 10% ointment No significant $

Apply up to QID adverse effects.
Protectants petrolatum, Apply up to QID No significant $

white adverse effects.
Vasoconstrictors phenylephrine 0.25% gel Possible Onset of action $$

Preparation H- Apply every systemic ranges from a
PE Gel morning and absorption if few seconds to
evening and applied to 1 min. Duration
after each bowel abraded skin of action is 2–3
movement PRN (increased blood h. Theoretically
pressure, CNS may interact
disturbances, with MAOIs,
cardiac including RIMAs
arrhythmia, (increased
aggravation of systemic
symptoms of adverse effects
hyperthyroidism). of
vasoconstrictor)
but no
published
reports. Caution
if heart disease,
hypertension,
thyroid disease,
diabetes,
prostatic
hypertrophy.
Yeast yeast 1% No significant Insufficient $$

Derivatives Preparation H ointment/cream; adverse effects. evidence to
22 mg confirm
suppository efficacy.
Use every
morning and
evening and
after each bowel
movement PRN
to improve
wound healing
a
Cost of duration of treatment or smallest available pack size; includes drug cost only.
Abbreviations: CNS = central nervous system; MAOI = monoamine oxidase inhibitor; RIMA = reversible inhibitor of
monoamine oxidase type A
Legend: $ <$5 $$ $5–10 $$$ $10–15
Suggested Readings
Lohsiriwat V. Hemorrhoids: from basic pathophysiology to clinical management. World J Gastroenterol
2012;18:2009-17.
Ross NP, Hildebrand DR, Tiernan JP et al. Haemorrhoids: 21st-century management. Colorectal Dis
2012;14:917-9.
Wald A, Bharucha AE, Cosman BC et al. ACG clinical guideline: management of benign anorectal disorders.
Am J Gastroenterol 2014;109:1141-57.
References
1. Haas PA. The prevalence of confusion in the definition of hemorrhoids. Dis Colon Rectum 1992;35:290-
1.
2. Pfenninger JL, Zainea GG. Common anorectal conditions: Part I. Symptoms and complaints. Am Fam
Physician 2001;63:2391-8.
3. Pfenninger JL, Zainea GG. Common anorectal conditions: Part II. Lesions. Am Fam Physician
2001;64:77-88.
4. Brisinda G. How to treat haemorrhoids. Prevention is best; haemorrhoidectomy needs skilled
operators. BMJ 2000;321:582-3.
5. Hulme-Moir M, Bartolo DC. Hemorrhoids. Gastroenterol Clin North Am 2001;30:183-97.
6. MacKay D. Hemorrhoids and varicose veins: a review of treatment options. Altern Med Rev 2001;6:126-
40.
7. Johanson JF, Sonnenberg A. The prevalence of hemorrhoids and chronic constipation. An
epidemiological study. Gastroenterology 1990;98:380-6.
8. Mazier WP. Hemorrhoids, fissures and pruritus ani. Surg Clin North Am 1994;74:1277-92.
9. Johannsson HO, Graf W, Pahlman L. Bowel habits in hemorrhoid patients and normal subjects. Am J
10. Madoff RD, Fleshman JW; Clinical Practice Committee, American Gastroenterological Association.
American Gastroenterological Association technical review on the diagnosis and treatment of
hemorrhoids. Gastroenterology 2004;126:1463-73.
11. Staroselsky A, Nava-Ocampo AA, Vohra S et al. Hemorrhoids in pregnancy. Can Family Physician
2008;54:189-90.
12. Altomare DF, Rinaldi M, La Torre F et al. Red hot chili pepper and hemorrhoids: the explosion of a myth:
results of a prospective, randomized, placebo-controlled, crossover trial. Dis Colon Rectum
2006;49:1018-23.
13. Wald A, Bharucha AE, Cosman BC et al. ACG clinical guideline: management of benign anorectal
disorders. Am J Gastroenterol 2014;109(8):1141-57.
14. Alonso-Coello P, Guyatt G, Heels-Ansdell D et al. Laxatives for the treatment of hemorrhoids. Cochrane
Database Syst Rev 2005;(4):CD004649.
15. Shafik A. Role of warm-water bath in the anorectal conditions. The “thermosphincteric reflex”. J Clin
16. Johanson JF. Nonsurgical treatment of hemorrhoids. J Gastrointest Surg 2002;6:290-4.
17. MacRae HM, McLeod RS. Comparison of hemorrhoidal treatment modalities. A meta-analysis. Dis
Colon Rectum 1995;38:687-94.
18. Clinical Practice Committee, American Gastroenterological Association. American Gastroenterological
Association medical position statement: Diagnosis and treatment of hemorrhoids. Gastroenterology
2004;126:1461-2.
19. American Society of Health-System Pharmacists. AHFS drug information. Bethesda: Board of the
American Society of Health-System Pharmacists; 2015.
20. Univeristy of Saskatchewan. medSask. Hemorrhoids: guidelines for prescribing rectal hydrocortisone
combination products. Available from: medsask.usask.ca/professional/guidelines/hemorrhoids.php.
Accessed February 16, 2016.
21. Health Canada. Anorectal drug products. Labelling standard. Available from: www.hc-sc.gc.ca/dhp-
mps/prodpharma/applic-demande/guide-ld/label-etiquet-pharm/anorecta-eng.php. Accessed
February 16, 2016.
22. Perera N, Liolitsa D, Iype S et al. Phlebotonics for haemorrhoids. Cochrane Database Syst Rev
2012;8:CD004322.
23. Natural Medicines Comprehensive Database. Jellin JM, ed. Stockton: Therapeutic Research Faculty.
Available from: naturaldatabase.therapeuticresearch.com. Subscription required.
24. Sirtori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res
2001;44:183-93.
25. Ernst E, ed. The desktop guide to complementary and alternative medicine. London: Harcourt
Publishers; 2001.
26. Zip C. A practical guide to dermatological drug use in pregnancy. Skin Therapy Lett 2006;11:1-4.
27. Ward KE, O”Brien BM. Pregnancy and lactation: therapeutic considerations. In: DiPiro JT, Talbert RL,
Yee GC et al., eds. Pharmacotherapy: a pathophysiologic approach. 9th ed. New York: McGraw-Hill
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28. Kaidar-Person O, Person B, Wexner SD. Hemorrhoidal disease: a comprehensive review. J Am Coll Surg
2007;204:102-17.

Hemorrhoids
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients.
Once printed there is no quarantee the information is up-to-date. [Printed on: 08-02-2017 12:12 PM]
Infant Colic
Shelita Dattani, BSc(Pharm), PharmD

Date of Revision: January 2018
Peer Review Date: February 2016
Introduction
Colic is reported in approximately 10–20% of healthy infants.1,2 The most accepted definition of colic is
the Wessel rule of three, which defines colic as unexplained paroxysmal bouts of fussing and crying that
last more than 3 hours a day, for more than 3 days a week, and for greater than 3 weeks.1,3,4,5
The term colic is imprecise and frequently overused. Although crying is an integral component of colic, a
behavioural definition includes increased motor activity and altered patterns of sleeping and eating.1,5,6
It is often associated with clenched fists, reddening of the face, drawing up of the legs, abdominal
distention and flatus.1 Occasionally, excessive regurgitation and vomiting can occur.1,5,7,8
Pathophysiology
Infantile colic is a diagnosis of exclusion and is considered when an otherwise thriving infant presents
with crying that is often inconsolable and when other causes such as infections, trauma, metabolic
disorders, foreign bodies, gastrointestinal, central nervous system or cardiovascular issues are ruled out.
It usually starts around the 2nd week of life and is most common in infants 4–6 weeks of age. It
gradually improves, becomes uncommon at 3–4 months of age and beyond, and is not associated with
any long-term consequences.9 A normal diurnal variation has been noted, with crying more often in the
late afternoon or evening.5,10,11 Males and females are affected with equal frequency.1,3,10 Limited data
suggest that colic may be more likely in babies whose mothers smoke.12 Colic occurs in both breastfed
and formula-fed babies. There is no evidence of a genetic predisposition to colic.1,10,11
Although the exact etiology of colic is unknown, proposed causes include organic, behavioural and
psychological components (see Table 1).13 A combination of these factors may be implicated in any
given infant. Some experts believe that colic may be best viewed as a clinical manifestation of normal
emotional development, in which an infant has diminished capacity to regulate crying duration.6,8,9
Parents will become frustrated if they try to pinpoint the exact cause of the baby’s colic.
14
Table 1: Proposed Causes of Infant Colic
Proposed Cause Possible Rationale
Organic Carbohydrate intolerance, intestinal gas, motility disorder,
gastroesophageal reflux, immature central and autonomic nervous
system, milk or food allergy, altered intestinal microflora.
Behavioural Improper feeding or feeding technique, smoking in the home.
Psychological Difficulties with parent-child interaction.
Goals of Therapy
Decrease frequency or duration of crying episodes to less than 3 hours per day, less than 3 days per
week6,8,10
Infant eating well and thriving
Infant has less or minimal fussiness after eating
Avoid dehydration of infant
Infant is able to fall asleep
Minimize adverse effects of recommended therapies
Minimize parental stress and frustration and help strengthen coping skills
Patient Assessment
An assessment algorithm for infants with suspected colic is illustrated in Figure 3. A complete history
and physical examination should be performed to rule out any organic causes of crying or underlying
medical conditions.
Nonpharmacologic therapy is the mainstay of treatment of colic. Since the cause of colic is unknown,
there are as many nonpharmacologic treatments as there are proposed etiologies. Furthermore, there is
a lack of evidence to support the efficacy of these interventions.1,6,11 Take a holistic approach when
advising parents of treatment strategies, and provide information on community support to give parents
the opportunity to share and consult with other parents. Parents should be reassured that any given
strategy may or may not work and that flexibility is essential to success.
Physical Methods
Methods that have been attempted include gentle pressure to the abdomen, carrying, rocking,
swaddling, skin-to-skin contact, use of infant carriers or massage. There are several forms of
massage, including whole-body massage and belly massage (infant facing downward in one hand;
parent starts from the navel and massages abdomen in clockwise motion).15 Figure 1 illustrates how
to hold the baby and Figure 2 illustrates the correct method of belly massage.
Babies who demonstrate possible gastric distress by pulling their legs up and arching their backs
may derive some relief if their legs are gently pushed back and forth, in an alternating or “bicycle”
motion. Repetitive motion relaxes infants and physical contact from the parent or caregiver may have
a calming effect.1,6
Warm baths may relieve gastrointestinal spasm. Heating pads should not be used due to the risk of
burning the infant. Evidence for the efficacy of chiropractic spinal manipulation is inconclusive—
parents should be discouraged from trying this approach.7
Figure 1: How to Hold the Baby

Figure 2: How to Massage the Baby
Behavioural Management
Table 2 lists some common causes of crying and provides basic management strategies. Crying is
one of the few ways a baby can communicate, and the parental response reassures the infant that
someone is listening. The strategies below can be attempted in any order. If the baby continues to
cry, parents should move on to another strategy and not persist with any one measure.6
1,5,6
Table 2: Behavioural Management Strategies for Parents of Crying Babies
Problem Symptoms Potential Strategies
Hunger Crying between feedings. Hunger periods often do not follow a

Inadequate weight gain regular pattern.
Increase feeding frequency as needed.
Poor feeding Refusing bottle or breast Poor feeding may be indicative of a serious
health problem and may lead to
dehydration. Consult with a health-care
practitioner.
Problem Symptoms Potential Strategies
Overheated Crying when tightly Loosen covers, reduce clothing, reduce

swaddled or layered room temperature.
Need for Crying or fussiness when Hold, rock or cuddle baby. Do not worry
attention or left alone about spoiling the infant or contributing to
physical contact a bad habit.
Insomnia Crying, inability to sleep Avoid excessive stimulation or arousal

at bedtime before bedtime.
Tiredness Crying or fussiness when Put the baby down in a dark, quiet room.
handled Unless crying excessively, babies can be
left alone for short intervals to see if they
will fall asleep on their own. Babies who
are crying loudly should be picked up and
held or rocked quietly until they fall asleep.
Lack of Crying or fussiness when Play with the baby, provide a visual or
stimulation left alone auditory distraction or place baby in an
infant seat or swing where there is a lot of
activity, e.g., kitchen.
Ear infection Crying or irritability; infant Requires further assessment and possibly
may be fingering or treatment, particularly if temperature
pulling on ear. Infant may >38°C and <3 months of age (even if other
not be sleeping or eating symptoms of ear infection are absent).
well. May be
accompanied by or
preceded by a cold.
Occasionally, fluid may be
draining out of the ear
canal. Fever may be
present
Teething Crying, excessive Rub the baby’s gums with a clean finger or
salivation, inflamed offer a rubber teething ring. Refrain from
gums. Typically begins using teething biscuits.
after 5 months of age
A colic diary that documents crying and fussing spells can assist parents and health-care
practitioners in creating a management strategy by helping to establish some patterns in the infant’s
day. Parents can log their behaviours, look for patterns and then try to modify these behaviours to see
if the situation improves. A routine schedule for feeding, holding, playtime and general care can be
developed once patterns are established. At the very least, keeping a diary gives a parent a better
sense of control and a clearer perspective of a frustrating situation.1,16
It is imperative that the caregiver has sufficient rest breaks when symptoms can no longer be
tolerated. Parental tension will make everyone’s distress worse.
Even though colic is usually self-limiting for the infant, it can take some time to repair the parent-
infant attachment relationship. If families continue to have difficulty coping with their usual sources
of support and despite reassurance by their health-care practitioner, they may be referred to a mental
health professional (e.g., counsellors, psychologists).1,6
Environmental Manipulation
Although white noise has anecdotally been comforting to some infants, evidence of the efficacy of
strategies using vibration or sound comes from uncontrolled studies and is inconclusive.17
Additionally, available evidence suggests that increased carrying, car rides or car-ride simulators and
baby swings are not effective in the management of colic symptoms.1,7,8,17
If parents try a series of calming techniques without using any one consistently for at least a day, the
infant may get overstimulated, which can make the colicky situation worse. Other parents give up
trying and withdraw from their infants, which can lead to spiralling parent and infant stress.1,6
Dietary Manipulation
The majority of the dietary manipulations recommended below require specialized follow-up.
Breastfeeding
Breastfeeding should be continued since the incidence of colic in breastfed and bottle-fed infants
is similar, and weaning a colicky infant to formula can result in symptoms worsening.1,8
Limited data suggest that prolonged emptying of 1 breast at each feed (vs. equal drainage of both
breasts at each feed) is associated with a lower incidence of colic.18
The link between food allergies and infant colic in children without other symptoms of atopy is
controversial.19 However, if there is suspicion of food allergies in a colicky baby, health-care
practitioners may advise that bottle-fed babies receive extensively hydrolyzed cow’s proteins. If
the baby is breastfeeding, the mother could be advised to eliminate certain foods from her diet,
e.g., cow’s milk protein and dairy products, soy, wheat, eggs, peanuts, tree nuts and fish for 1–2
weeks; recommend that the mother takes calcium supplementation if milk and its products are
eliminated from her diet.1,5,19,20,21
Foods noted to aggravate colic in breastfed infants include cabbage, broccoli, caffeine, citrus fruit
and chocolate. Limited data suggest that eliminating these foods from the mother’s diet for a
period of time may help with colicky symptoms.1,19 Removing too many foods, however, may have
an adverse effect on the mother’s nutrition and generate additional stress. Consider referral to a
dietitian before significant modifications occur.1,5
Formula Feeding
Substituting traditional formulas with hypoallergenic (casein hydrolysate, whey hydrolysate)

formula may reduce duration of crying but may be associated with an increased cost to families
and may be less palatable than traditional infant formulas.5,17,19,22 Hypoallergenic formulas
should be reserved for infants with confirmed allergies to cow’s milk protein.7 The use of soy
protein–based formulas in the treatment of colic is not supported by adequate data.11,22
Evidence for the use of lactose-reduced formula or lactase enzyme supplementation is not
sufficient to draw conclusions about efficacy of these treatments for colic.6,10,19,22 The addition
of fibre to formula is not effective.8,10,19
If formula changes are made, they should not be pursued if symptoms do not improve after 1
week.6,8 Frequent formula changes are not recommended.6,8
Feeding Techniques
The following simple techniques can be helpful in feeding a colicky bottle-fed infant:
To prevent regurgitation and promote the exit of swallowed air, infants should be held in a
vertical position during feeding, with the head higher than the feet1,6
It is important to use the correct bottle and nipple size for the infant’s age. Curved bottles allow
the infant to be fed while sitting up, and bottles with a collapsible bag may decrease air
swallowing. Changing the nipple of the bottle to one with a smaller hole or anticolic design may
prevent frequent colic attacks, although the effects of these measures have not been formally
studied.1
Infants should be burped in an upright position, with the baby held over the shoulder or in a
gentle chin grasp. Burping should be encouraged after every 30–60 mL of formula ingested or
after every 5–10 minutes of breastfeeding.1,6
Ailments—Baby Care Products: Gastrointestinal.
Over the years, different medications have been recommended for the management of colic. The
efficacy of pharmacologic agents in the treatment of colic is difficult to assess due to the highly
subjective nature of the problem, undetermined etiology, poorly designed trials, conflicting results and
high placebo effect noted in clinical trials.9,17,19 Furthermore, the age of the patient group and fear of
possible harm to the infant makes it difficult to conduct research aimed at developing more effective
medications. Before pharmacologic agents are tried, ensure that nonpharmacologic measures have been
used to their fullest potential. Table 4 describes various pharmacologic therapies for colic.
If pharmacologic therapy is attempted:
Start with the lowest dose and increase incrementally only when necessary based on symptoms
Use only intermittent dosing when necessary based on symptoms
NOTE: most of the pharmacologic agents available provide questionable benefit and are not
routinely recommended in the treatment of colic
Natural Health Products and Probiotic Remedies
Preparations containing fennel oil or the probiotic Lactobacillus reuteri appear to be effective in
reducing crying times in colicky infants.26,27,28 No clinically meaningful adverse effects have been
reported but long-term safety has not been established. Probiotics require at least 2–4 weeks of
continuous treatment at appropriate doses to show effect and treatment with probiotics requires
more study before being widely adopted.
Table 3 provides a framework for a monitoring plan that should be individualized for each patient.
16
Table 3: Monitoring of Therapy for Infant Colic
Excessive Parent: daily—log Decrease in frequency If current treatment
crying in behaviour in a colic diary or duration of crying strategy is not effective,
infant to assess patterns and episodes to <3 h per try another strategy
document associated day, <3 days per wk. based on patterns
symptoms noted in diary. If still
Health-care practitioner: ineffective after 3 days,
after 3 days or at next further investigation is
visit. Review diary with required to rule out
parent organic etiology for
crying.
If crying is associated
with poor feeding, fever,
vomiting, dehydration or
significant change in
stool or urination
pattern, or if infant cries
for ≥3 h without
stopping, an immediate
and thorough
assessment is required.
Parental Parent: daily Decrease in parental Reassure parents and

anxiety Health-care practitioner: anxiety and frustration. re-emphasize coping
after 3 days or at next Improved parental strategies. Remind
visit coping skills. them to take “time out”
rest periods away from
the infant. If they
continue to seem
frustrated or
overwhelmed, refer to
an appropriate health-
care practitioner for
counselling.
Infant Parent: daily—log Infant able to fall Health-care practitioner

agitated or behaviour in diary and asleep. should perform a
unable to fall document associated Infant calm before complete history and
asleep symptoms bedtime or naptime. physical examination. If
Health-care practitioner: serious issues are ruled
after 3 days or at next out, environmental
visit. Review diary with manipulation or other
parent soothing techniques
can be tried.
Infant Parent: daily—log Less or minimal A thorough physical
refuses to behaviour in diary and fussiness after eating. assessment for weight
eat or has indicate whether related No weight loss or signs loss or signs of
excessive to other symptoms such of dehydration. dehydration is required.
fussiness as gas, fever, Suggest that caregiver
after eating constipation. If signs of discuss with an
dehydration are noted appropriate health-care
(e.g., tearless crying, practitioner alterations
reduced urination to <4 in maternal diet or
diapers/day, sunken eyes, formula to rule out
dry skin and mouth, allergenic component
sunken fontanelle), the to colic.
child should be assessed
by a health-care
practitioner immediately
Health-care practitioner:
look for signs of
dehydration and monitor
infant’s body weight as
required. Infants <3
months of age may
require hospital
admissions to rule out
sepsis
Advice for the Caregiver

Advise caregivers of colicky babies regarding:
When to seek medical advice (see Table 3)

Nonpharmacologic management strategies
Proper use of any drug therapy chosen
Expected results of any drug therapy and management of adverse effects
Resources
Parents can call their regional health department’s parent-child information line or their local childrens’
hospital hotline for more information on community support for parents of colicky babies. The Internet
can be an extensive source of information but is also inundated with endorsements or advertisements
for products that have not been proven effective or safe in the treatment of colic. Parents should be
cautioned about this and encouraged to look for legitimate websites such as the site maintained by the
Canadian Paediatric Society.8
Internet-based Information on Colicky Infants:
Canadian Paediatric Society. www.cps.ca.
Keyword search: colic.
WebMD. www.webmd.com.
Keyword search: colic.
Algorithms
Figure 3: Assessment of Infants with Suspected Colic
a Recommend that caregiver maintain a colic diary for 48–72 hours that documents crying and fussing spells
and associated symptoms. Parents should also log infant’s sleeping, feeding, playtime and bowel movements
in this diary.
Drug Table
Table 4: Pharmacologic Therapy for Infant Colic
Dosage Mechanism of Adverse Comments
Agents/Costa Action Effects
Drug Class: Carbohydrates
sucrose Dissolve 5 g of Proposed None Limited data show

sucrose (table or analgesic effect reported. 63% of infants
$ granulated in infants. Short- respond with
sugar) in 40 mL acting response; decrease in
water (12% lasts <30 min. symptoms but
solution) and short duration of
give 2 mL to action of sucrose
infant via may limit its
dropper. Increase practical use.23
concentration to More well-
25–50% if controlled research
necessary (7.5– is needed before
15 g sucrose in this treatment can
30 mL water, be widely
respectively) recommended. If
solution is not
administered right
away, store in
refrigerator and
inspect for changes
in appearance
before
administration.
Do not substitute
with honey because
of risk of botulism
in infants.
Drug Class: Carminatives
simethicone 0.25–0.5 mL Based on the No Ineffective but

Infacol, Ovol, (10–20 mg) with possible etiology clinically safe.22 May be
generics or after each of gas in colic. meaningful useful because of
feeding as Antiflatulent; adverse potential placebo
$ necessary. May effects due effect.
alters surface
be added to tension of mucus to lack of
formula or given and allows systemic
directly from entrapped gas absorption.
dropper bubbles to
Maximum: 6 mL coalesce and be
per 24 h more easily
released by the
mouth or anus.
Drug Class: Probiotic Agents

Dosage Mechanism of Adverse Comments
Agents/Costa Action Effects
Lactobacillus 108 colony- Based on data No Data demonstrate

reuteri forming units per demonstrating clinically meaningful and
BioGaia, day 30 min after lower counts of meaningful significant
others feeding intestinal adverse reduction in crying
lactobacilli in effects. times in as early as
$ colicky infants. 7 days of
Probiotic treatment.13,14,24,25
supplementation Additional studies
can favourably are needed to
alter the balance determine whether
of intestinal other probiotic
lactobacilli in strains may be
infants with beneficial.
colic. Refrigerate when
not in use.
a Cost of 1 dose; includes drug cost only.
Legend: $ <$2
Suggested Readings
Canadian Paediatric Society. Infantile colic: is there a role for dietary interventions? Available from:
www.cps.ca/documents/position/infantile-colic-dietary-interventions.
Cohen-Silver J, Ratnapalan S. Management of infantile colic: a review. Clin Pediatr (Phila) 2009;48:14-7.
Dobson D, Lucassen PL, Miller JJ et al. Manipulative therapies for infantile colic. Cochrane Database Syst
Rev 2012;12:CD004796.
Gupta SK. Update on infantile colic and management options. Curr Opin Investig Drugs 2007;8:921-6.
References
1. Berkowitz CD. Management of the colicky infant. Compr Ther 1997;23:277-80.

2. Sferra TJ, Heitlinger LA. Gastrointestinal gas formation and infantile colic. Pediatr Clin North Am
1996;43:489-510.
3. Reust CE, Blake RL. Diagnostic workup before diagnosing colic. Arch Fam Med 2000;9:282-3.
4. Wessel MA, Cobb JC, Jackson EB et al. Paroxysmal fussing in infancy, sometimes called colic.
Pediatrics 1954;14:421-35.
5. Gupta SK. Update on infantile colic and management options. Curr Opin Investig Drugs
2007;8:921-6.
6. Balon AJ. Management of infantile colic. Am Fam Physician 1997:55:235-42, 245-6.
7. Cohen-Silver J, Ratnapalan S. Management of infantile colic: a review. Clin Pediatr (Phila)
2009;48:14-7.
8. Roberts DM, Ostapchuk M, O'Brien JG. Infantile colic. Am Fam Physician 2004;70:735-40.
9. Kanabar D. Infantile colic. J Fam Health Care 2004;14:1-2.
10. Clemons RM. Issues in newborn care. Prim Care 2000;27:251-67.
11. Savino F. Focus on infantile colic. Acta Paediatr 2007;96:1259-64.
12. Reijneveld SA, Lanting CI, Crone MR et al. Exposure to tobacco smoke and infant crying. Acta
Paediatr 2005;94:217-21.
13. Savino F, Cordisco L, Tarasco V et al. Lactobacillus reuteri DSM 17938 in infantile colic: a
randomized, double-blind, placebo-controlled trial. Pediatrics 2010;126:e526-33.
14. Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of
infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial. J Pediatr
2013;162:257-62.
15. Larsen JH. Infants' colic and belly massage. Practitioner 1990;234:396-7.
16. Personal communication. Barry Lester, PhD, Director of Infant Development Center, Professor in
Departments of Psychiatry and Pediatrics, Brown University.
17. Lucassen PL, Assendelft WJ, Gubbels JW et al. Effectiveness of treatments for infantile colic:
systematic review. BMJ 1998;316:1563-9.
18. Evans K, Evans R, Simmer K. Effect of the method of breast feeding on breast engorgement,
mastitis and infantile colic. Acta Paediatr 1995;84:849-52.
19. Nocerino R, Pezzella V, Cosenza L et al. The controversial role of food allergy in infantile colic:
evidence and clinical management. Nutrients 2015;7:2015-25.
20. Lucassen PL, Assendelft WJ, Gubbels JW et al. Infantile colic: crying time reduction with a whey
hydrolysate: a double-blind, randomized, placebo-controlled trial. Pediatrics 2000;106:1349-54.
21. Hill DJ, Roy N, Heine RG et al. Effect of a low-allergen maternal diet on colic among breastfed
infants: a randomized, controlled trial. Pediatrics 2005;116:e709-15.
22. Wade S, Kilgour T. Extracts from “clinical evidence”: Infantile colic. BMJ 2001;323:437-40.
23. Markestad T. Use of sucrose as a treatment for infant colic. Arch Dis Child 1997;76:356-7.
24. Savino F, Pelle E, Palumeri E et al. Lactobacillus reuteri (American Type Culture Collection Strain
55730) versus simethicone in the treatment of infantile colic: a prospective randomized study.
Pediatrics 2007;119:e124-30.
25. Savino F, Cordisco L, Tarasco V et al. Lactobacillus reuteri DSM 17938 in infantile colic: a
randomized, double-blind, placebo-controlled trial. Pediatrics 2010;126:e526-33.
26. Harb T, Matsuyama M, David M et al. Infant colic—what works: a systematic review of
interventions for breastfed infants. J Pediatr Gastroenterol Nutr 2016;62:668-86.
27. Xu M, Wang J, Wang N et al. The efficacy and safety of the probiotic Bacterium Lactobacillus
reuteri DSM 17938 for infantile colic: a meta-analysis of randomized controlled trials. PLoS One
2015;10:e0141445.
28. Fatheree NY, Liu Y, Taylor CM et al. Lactobacillus reuteri for infants with colic: a double-blind,
placebo-controlled, randomized clinical trial. J Pediatr 2017;191:170-8.

Infant Colic
Irritable Bowel Syndrome
Lynette Kosar, BSP, MSc (Pharm)

Introduction
Irritable bowel syndrome (IBS), also referred to as spastic colon or irritable colon, is a common functional bowel disorder with
no identifiable structural or biochemical abnormalities. Generalizations about IBS are difficult as patient presentation varies. The
condition encompasses abdominal pain or discomfort with altered bowel habits.1,2 Other symptoms that characterize the
disorder include abdominal bloating, cramping and/or passage of mucus in the stool. IBS can be divided into 3 subtypes:
constipation-predominate (IBS-C), diarrhea-predominate (IBS-D), and mixed (IBS-M), a combination of both diarrhea and
constipation.1 Symptoms cycle through phases of exacerbations and remissions, and subtypes may change over time. Patients
will often seek medical care when they are concerned their symptoms may represent a life-threatening disorder.
Canada has one of the highest rates of IBS in the world with approximately 5 million Canadians living with this condition.3
Women are 1.5–2 times more likely to be diagnosed with IBS than men, and it is more common in lower socioeconomic groups
and those younger than 50 years.1,4 Patients often endure a significantly impaired quality of life, an impact similar to that of
diabetes, renal disease or hypertension. Mental health may be negatively affected and clinicians should be vigilant for signs of
depression. IBS patients use >50% more healthcare resources than those without IBS.1
Pathophysiology
A variety of pathophysiologic changes occur in patients with IBS. These include altered neurologic function and sensitivity to
stimuli, altered GI motility and abnormal psychosocial features.
Nociceptive stimuli in the GI tract provide input to pain centres that are augmented by psychosocial factors leading to the
patient's sensation and interpretation of pain.5 Patients with IBS are often found to have increased sensitivity to distension in
the rectum, ileum and esophagus.6,7 Pain may be associated with altered motility in the small intestine. An altered balance of
neurotransmitters in the GI tract may also be involved. Emotional stress is known to cause changes in GI motility in both the
small and large intestine.5
Within IBS referral clinics, reports of psychological features can be high, with over half of patients meeting the clinical criteria for
depression.8 In addition, anxiety and somatization (the tendency to overinterpret physiological symptoms) disorders also
appear more frequently in patients with IBS. Abuse (physical, sexual) may be reported in one-third of subjects. In patients with
IBS who do not seek physician assessment, it is not certain whether these psychological features are present.
Between 60% and 70% of patients with IBS believe certain foods trigger their symptoms.1 The prevalence of lactose intolerance
in the IBS population is estimated to be 38% compared with 26% in the general population.1 The odds of having celiac disease
are 5 times higher in patients with IBS compared with the general population.1,9
After an acute illness with a GI pathogen (e.g., Campylobacter, Shigella, Salmonella), some previously healthy individuals may
develop persistent IBS symptoms. Likely less than one-third of IBS can be related to an infectious precipitant.10
Goals of Therapy
Improve quality of life by minimizing (or eliminating, if possible) diarrhea, constipation, abdominal pain, bloating, or
intestinal spasms
Treat any existing psychiatric disorders
Reassure and educate patient regarding the benign nature of IBS
Patient Assessment
IBS is diagnosed when the patient has experienced recurrent abdominal pain or discomfort at least 3 days per month in the past
3 months with symptom onset at least 6 months prior to the diagnosis, and is associated with at least 2 of the following:
improvement with defecation
onset associated with a change in frequency of stool
onset associated with a change in form (appearance) of stool.
The accuracy of IBS diagnosis is further strengthened by the absence of alarm signs and symptoms (e.g., rectal bleeding, iron
deficiency anemia, fever, weight loss, onset of symptoms in patients >50 years old, family history of colorectal cancer, nocturnal
symptoms, recent progressive symptoms). Patients with alarm features, mental health impacted by IBS symptoms or IBS-D or
IBS-M subtypes should undergo further diagnostic evaluation.
When assessing GI symptoms, consider their duration, severity and course. Recurrent symptoms over months to years are
suggestive of a functional GI disorder such as IBS. Symptoms of recent onset or becoming steadily more severe, especially over
a short time period, are suggestive of an organic GI disorder. Patients with symptoms of IBS should initially undergo a basic
diagnostic workup to confirm the diagnosis of IBS and to rule out organic GI disorders such as infections, when applicable.
Patients with IBS-D or IBS-M should be tested for celiac disease.
The Bristol Stool Scale can help patients communicate their stool consistency to healthcare practitioners, especially when the
patient is hesitant to discuss his/her bowel patterns in a public setting (e.g., community pharmacy). The Bristol Stool Scale
distinguishes diarrhea from constipation, and is useful for monitoring response to therapy (see Figure 1).11
Acute flares of IBS may be altered by removing triggers and dealing with psychological issues. Perform a careful medication
history on all patients. Medications and natural health products can be potential sources of GI adverse effects. Constipation, for
example, could be caused by opioids, minerals (iron, calcium, aluminum), anticholinergic agents, loperamide and the calcium
channel blockers verapamil and diltiazem. Diarrhea, on the other hand, could be caused by antibiotics, magnesium and
laxatives. NSAIDs may cause either constipation or diarrhea.
Important complications of IBS are the loss of productivity and consumption of healthcare resources related to the disorder.
Many patients see a number of different healthcare practitioners. Unrealistic expectations can arise, especially with regard to
drug therapy. The patient's goals can be unrealistic; goal planning with the patient and other healthcare providers is an important
part of the treatment plan. Prevention of IBS is difficult to achieve on a consistent basis.
a
Figure 1: Bristol Stool Chart
a Types 1–2 indicate constipation, types 3–4 represent ideal stool consistencies as they are easier to pass and types 5–7 may indicate
diarrhea and urgency.
Reproduced with permission from Thompson WG, Heaton KW. Fast facts: irritable bowel syndrome. 2nd ed. Oxford (GB): Health Press Limited; 2003.
Patient symptoms should guide the therapeutic plans (e.g., pain, bloating, gas, diarrhea, constipation). A key component of the
therapeutic plan is patient reassurance. The likelihood of a serious organic GI disease such as cancer is likely no different in IBS
than the general population.1 In general, therapies are likely to offer only limited relief over the long term. Counselling patients
on the high likelihood for recurrence is important.
Nondrug therapies for IBS include establishing a nonjudgmental therapeutic relationship with the patient, exercise,12 stress
management13 and counselling for psychological issues.14 Consider lactose intolerance; consumption of dairy products may be
decreased, at least on a trial basis. Patients with IBS-D or IBS-M may benefit from serologic testing for celiac sprue.
Avoidance of lifestyle triggers such as excessive caffeine or fruit intake is a usual component of the treatment plan. Gluten-free
and low-FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) diets may improve IBS
symptoms; however, there is insufficient evidence to recommend food allergy testing or exclusion diets.2 If patients insist on
dietary restrictions, instruct them to keep a food diary and monitor to avoid nutritional deficiencies. The diary is particularly
helpful in determining whether lactose is a trigger. This may be accomplished with guidance from a dietitian.
Foods that are most often reported to contribute to IBS symptoms include:
dairy products
cereals (e.g., wheat, oats and corn)
citrus fruit
potatoes
caffeinated drinks
fat
alcohol
simple sugar alternatives (e.g., fructose, lactose, sorbitol)
an excess or insufficient intake of dietary fibre.
For further discussion of pharmacologic therapy for IBS, consult the Compendium of Therapeutic Choices: Irritable Bowel
Syndrome.
Gastrointestinal Products: Antidiarrheals, Laxatives.
Selected agents used in the management of IBS are described in Table 1.
In general, drug therapies for IBS are only marginally more effective than placebo over the long term. Short-term benefits over a
few weeks may be dramatic as there is a high placebo response (about 50%) to therapy in IBS.15 To date, only psychological and
dietary treatments have been found to provide sustained benefits.6 With any therapy, 4 weeks is generally considered the
minimum duration needed to determine efficacy.
Constipation
If lifestyle modifications (diet, exercise, increased fluids) fail, patients suffering from constipation can try fibre
supplementation.16,17 Soluble fibre (e.g., psyllium, calcium polycarbophil) is more effective than placebo in relieving
constipation and global IBS symptoms.2 Insoluble fibre (e.g., wheat or corn bran) is no different from placebo and may
actually worsen abdominal pain or bloating.16
Laxatives (e.g., bisacodyl, lactulose, magnesium salts, polyethylene glycol, senna) may be tried if fibre supplementation is
unsuccessful.17 Stimulant laxatives may cause abdominal cramps and lactulose may result in bloating.
Diarrhea
Loperamide is helpful in the management of diarrhea due to IBS (by decreasing stool frequency and urgency). Some patients
may experience nighttime abdominal pain when using loperamide.18 Fibre supplementation has been studied for IBS-related
diarrhea, but there is insufficient evidence to recommend its use.19
Abdominal Pain
Antidepressants
Expert recommendations are conflicting regarding the use and effectiveness of tricyclic antidepressants (TCAs) and
SSRIs in the management of IBS.2,20,21 SSRIs may improve global assessment and TCAs may improve abdominal pain
and symptom score in all IBS subtypes.22 Comorbid depression does not predict response. Since TCAs exhibit
anticholinergic properties and tend to increase GI transit time,23 they may be most appropriate for use in patients with
IBS-D. Conversely, SSRIs may decrease GI transit time and may be a more suitable choice in patients with IBS-C.23,24
St. John's wort is ineffective in the treatment of IBS.25

Antispasmodics
Low-quality evidence suggests that antispasmodics may provide short-term relief from abdominal pain and may improve
global assessment and symptom score.16 Available antispasmodics include dicyclomine, hyoscine, peppermint oil,
pinaverium and trimebutine.16,22 If recommending peppermint oil, ensure the formulation has a Natural Product Number
to reduce the risk of exposure to contaminated or inappropriately labelled products. Monitor IBS-C patients for worsening
of constipation as this is a potential side effect of these agents. For acute attacks, recommend dosing on as-needed
basis. In patients suffering from postprandial symptoms, scheduling an antispasmodic before meals may be warranted.
Bloating and Gas
Bloating and gas associated with IBS are usually managed with dietary changes (limitation of fibre intake and avoidance of
gas-producing vegetables). Treating constipation, if present, may alleviate bloating and gas. Fibre supplementation should
be used cautiously as it may worsen gas and bloating symptoms. Weak evidence suggests that fluoxetine may help relieve
constipation, abdominal pain and bloating in patients with IBS-C suffering from abdominal pain.24
Other Therapies
Probiotics have been investigated in the management of IBS symptoms. In general, probiotics may improve IBS symptoms,
disease severity score and quality of life but the magnitude of benefit and the most effective species and strain are
uncertain.26,27,28,29,30 Lactobacilli alone offers little if any improvements in IBS symptoms.1 Bifidobacteria shows promise;
however, additional evidence is required. Combinations of probiotics may be more effective than single entities.1
There are insufficient data to support the use of other alternative therapies in IBS.1 Acupuncture provides no benefit when
compared with sham acupuncture in IBS patients.31
Monitor diets as they often become more restrictive over time since many patients with IBS associate their symptoms with
particular foods. Ensure that patients who withhold dairy products maintain supplemental intake of calcium and vitamin D.
Advise patients of the alarm features of serious GI pathology (see Patient Assessment).
Symptoms often recur or present differently over the course of time. In more difficult cases, patient dissatisfaction with care
increases. A long-term care plan is important as patients frequently seek new alternative sources of heath care to deal with
persisting or recurrent symptoms. Good communication with other healthcare practitioners is especially important in this
difficult-to-manage group of patients with functional GI disorders.
Most therapeutic trials should be at least 1 month in length. Antidepressants often require 6 weeks or more to assess their
effectiveness. More than 1 antidepressant is often tried as there is interpatient variability in response to individual agents.
Drug Table
Table 1: Pharmacologic Therapy for Irritable Bowel Syndromea
Class Drug Dosage Adverse Effects Drug Interactions Comments Costb
Antispasmodics dicyclomine 10–20 mg Dry mouth, Contraindicated Used to relieve $

TID–QID drowsiness, in patients taking abdominal pain.
Bentylol, PRN or constipation, aclidinium, Avoid in patients
generics scheduled confusion, blurred glucagon and with
before vision. glycopyrrolate. tachyarrythmias,
meals angle-closure
glaucoma,
urinary retention,
hyperthyroidism.
The elderly are
more
susceptible to
adverse effects.
Has been used
in doses of up to
40 mg QID.
Antispasmodics peppermint 0.2–0.4 Heartburn, nausea, May increase Used to relieve $

oil mL in vomiting, flushing, cyclosporine abdominal pain.
enteric- headache, diarrhea, serum levels. Enteric-coated
coated anal burning. May be Contraindicated capsules reduce
capsules hepatotoxic in high in patients taking risk of
TID po doses. pimozide. heartburn.
taken Separate
between administration
meals of antacids, H2-
antagonists and
proton pump
inhibitors by 2 h.
Antidiarrheals loperamide 2–4 mg Abdominal cramps, No significant Used to relieve $

Imodium, up to QID drowsiness, dry drug interactions. diarrhea.
generics mouth, nausea and Individual dose
vomiting, skin rash. varies; can
cause
constipation.
Highest dose in
IBS trials was 12
mg/day. No
significant drug
interactions.
Bulk-forming polycarbophil 1000 mg Abdominal May impair May cause less $

Laxatives calcium daily po pain/bloating, absorption of oral gas or bloating
Prodiem Gradually epigastric fullness, bisphosphonates, than psyllium.
Tablets titrate to flatulence. fluoroquinolones,
QID as tetracylcines and
tolerated; thyroid
drink 240 hormones.
mL of
fluid with
each dose
Bulk-forming psyllium 3.4 g BID Abdominal No significant If palatability an $

Laxatives Metamucil po with pain/bloating, drug interactions. issue, try
Preparations, meals flatulence, cramps. another
generics Gradually Risk of intestinal formulation or
titrate to impaction/obstruction mix in beverage
12–20 if inadequate fluid to mask taste.
g/day as intake.
tolerated;
drink 240
mL of
fluid with
each dose
Osmotic lactulose 15–60 mL Flatulence, abdominal No significant Used to relieve $

Laxatives generics per day in cramps, diarrhea. May drug interactions. constipation.
1 or 2 cause bloating. Palatability may
divided Nausea more be an issue (very
doses common with higher sweet); may mix
doses. in beverage. No
significant drug
interactions.
Osmotic magnesium 15–30 mL Diarrhea. Risk of Contraindicated Used to relieve $

Laxatives hydroxide daily or hypermagnesemia in patients taking constipation.
Milk of BID po increased in patients misoprostol, Avoid in patients
Magnesia, with renal polystyrene with renal
generics dysfunction. sulfonate, dysfunction. Do
quinine. Oral not recommend
magnesium salts maximum dose
may decrease for more than 2
bioavailability of weeks unless
allopurinol, monitored by an
bisphosphonates, appropriate
cefuroxime, healthcare
chloroquine, practitioner.
corticosteroids,
dabigatran,
fluoroquinolones,
fosinopril, iron
salts,
itraconazole,
ketoconazole,
levothyroxine,
mycophenolate,
sotalol and
tetracyclines.
Magnesium salts
may decrease
effectiveness of
bisacodyl,
mesalamine and
methenamine.
Osmotic polyethylene 17 g daily Nausea, abdominal No significant Used to relieve $

Laxatives glycol po bloating, cramping, drug interactions. constipation.
Lax-A-Day, flatulence, diarrhea, May require 2–4
Pegalax, urticaria. days of therapy
RestoraLAX to produce a
bowel
movement.
Treatment
duration should
be limited to 1
wk unless
monitored by an
appropriate
healthcare
practitioner.
a
For more information on pharmacologic therapy for IBS, consult the Compendium of Therapeutic Choices: Irritable Bowel Syndrome.
b
Legend: $ <$1
Suggested Readings
Chang L, Lembo A, Sultan S. American Gastroenterological Association Institute Technical Review on the pharmacological
management of irritable bowel syndrome. Gastroenterology 2014;147:1149-72.e2.
Ford AC, Moayyedi P, Lacy BE et al. American College of Gastroenterology monograph on the management of irritable bowel
syndrome and chronic idiopathic constipation. Am J Gastroenterol 2014;109:S2-26.
Kosar L, Schuster B, Regier L et al. Irritable bowel syndrome–drugs for symptom management. RxFiles drug comparison charts.
10th ed. Saskatoon: Saskatoon Health Region; 2014. p. 66.
References
References
1. Brandt LJ, Chey WD, Foxx-Orenstein AE et al. An evidence-based position statement on the management of irritable
bowel syndrome. Am J Gastroenterol 2009;104:S1-35.
2. Ford AC, Moayyedi P, Lacy BE et al. American College of Gastroenterology monograph on the management of irritable
bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol 2014;109:S2-26.
3. Canadian Digestive Health Foundation. Digestive disorders. Available from: www.cdhf.ca/en/statistics#Irritable Bowel
Syndrome. Accessed February 16, 2016.
4. Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome: a clinical review. JAMA 2015;313:949-58.
5. Drossman DA. Diagnosing and treating patients with refractory functional gastrointestinal disorders. Ann Intern Med
1995;123:688-97.
6. Jones J, Boorman J, Cann P et al. British Society of Gastroenterology guidelines for the management of the irritable
bowel syndrome. Gut 2000;47:ii1-19.
7. Horwitz BJ, Fisher RS. The irritable bowel syndrome. N Engl J Med 2001;344:1846-50.
8. Clouse RE. Antidepressants for functional gastrointestinal syndromes. Dig Dis Sci 1994;39:2352-63.
9. Wong BS, Camilleri M, Carlson P et al. Increased bile acid biosynthesis is associated with irritable bowel syndrome with
diarrhea. Clin Gastroenterol Hepatol 2012;10:1009-15.e3.
10. Camilleri M. Management of the irritable bowel syndrome. Gastroenterology 2001;120:652-68.
11. Wilkins T, Pepitone C, Alex B et al. Diagnosis and management of IBS in adults. Am Fam Physician 2012;86:419-26.
12. Johannesson E, Simrén M, Strid H et al. Physical activity improves symptoms in irritable bowel syndrome: a randomized
controlled trial. Am J Gastroenterol 2011;106:915-22.
13. Fjorback LO, Arendt M, Ornbøl E et al. Mindfulness therapy for somatization disorder and functional somatic syndromes:
randomized trial with one-year follow-up. J Psychosom Res 2013;74:31-40.
14. Labus J, Gupta A, Gill HK et al. Randomised clinical trial: symptoms of the irritable bowel syndrome are improved by a
psycho-education group intervention. Aliment Pharmacol Ther 2013;37:304-15.
15. Patel SM, Stason WB, Legedza A et al. The placebo effect in irritable bowel syndrome trials: a meta-analysis.
Neurogastroenterol Motil 2005;17:332-40.
16. Ford AC, Talley NJ, Spiegel BM et al. Effect of fibre, antispasmodics and peppermint oil in the treatment of irritable
bowel syndrome: a systematic review and meta-analysis. BMJ 2008;337:a2313.
17. Drugs for irritable bowel syndrome. Treat Guidel Med Lett 2006;4:11-6.
18. Efskind PS, Bernklev T, Vatn MH. A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome.
Scand J Gastroenterol 1996;31:463-8.
19. Chouinard LE. The role of psyllium fibre supplementation in treating irritable bowel syndrome. Can J Diet Pract Res
2011;72:e107-14.
20. Weinberg DS, Smalley W, Heidelbaugh JJ et al. American Gastroenterological Association Institute Guideline on the
pharmacological management of irritable bowel syndrome. Gastroenterology 2014;147:1146-8.
21. National Institute for Health and Care Excellence (NICE). Irritable bowel syndrome in adults: diagnosis and management.
NICE guidelines [CG61]; Modified February 2015. Available from: /www.nice.org.uk/guidance/cg61. Accessed February
16, 2016.
22. Ruepert L, Quartero AO, de Wit NJ et al. Bulking agents, antispasmodics and antidepressants for the treatment of
irritable bowel syndrome. Cochrane Database Syst Rev 2011;(8):CD003460.
23. Gorard DA, Libby GW, Farthing MJ. Influence of antidepressants on whole gut and orocaecal transit times in health and
irritable bowel syndrome. Aliment Pharmacol Ther 1994;8:159-66.
24. Vahedi H, Merat S, Rashidioon A et al. The effect of fluoxetine in patients with pain and constipation-predominant
irritable bowel syndrome: a double-blind randomized-controlled study. Aliment Pharmacol Ther 2005;22:381-5.
25. Saito YA, Rey E, Almazar-Elder AE et al. A randomized, double-blind, placebo-controlled trial of St John's wort for treating
irritable bowel syndrome. Am J Gastroenterol 2010;105:170-7.
26. Williams EA, Stimpson J, Wang D et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms
of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther 2009;29:97-103.
27. Brenner DM, Moeller MJ, Chey WD et al. The utility of probiotics in the treatment of irritable bowel syndrome: a
systematic review. Am J Gastroenterol 2009;104:1033-49.
28. Ritchie ML, Romanuk TN. A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One 2012;7:e34938.
29. Kruis W, Chrubasik S, Boehm S et al. A double-blind placebo-controlled trial to study therapeutic effects of probiotic
Escherichia coli Nissle 1917 in subgroups of patients with irritable bowel syndrome. Int J Colorectal Dis 2012;27:467-74.
30. Whelan K. Probiotics and prebiotics in the management of irritable bowel syndrome: a review of recent clinical trials and
systematic reviews. Curr Opin Clin Nutr Metab Care 2011;14:581-7.
31. Manheimer E, Cheng K, Wieland LS et al. Acupuncture for treatment of irritable bowel syndrome. Cochrane Database Syst
Rev 2012;5:CD005111.

Irritable Bowel Syndrome
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients. Once printed there is
no quarantee the information is up-to-date. [Printed on: 08-02-2017 12:13 PM]
Nausea and Vomiting
Christine Hughes, BScPharm, PharmD

Pathophysiology
Nausea is the unpleasant sensation of the imminent need to vomit and may or may not lead to vomiting. Vomiting is the
forceful expulsion of gastric contents with contraction of the abdominal and chest wall musculature.1 Retching or “dry
heaves” is the same physiologic process as vomiting but without expulsion of gastric contents.
Nausea and vomiting can be associated with disorders of the gastrointestinal, endocrine or central nervous systems or
may be due to infections, medications, toxins or aberrant metabolic processes.1 Some causes of nausea and vomiting
are listed in Table 1.2 This chapter addresses the most commonly encountered causes of nausea and vomiting.
Syndromes that have a high incidence of nausea and vomiting, such as migraine headaches, are addressed in other
chapters (see Headache).
The pathophysiology of nausea and vomiting is complicated by the involvement of numerous neurotransmitters and
nerve systems arising from different organs and activated by a variety of stimuli (Figure 1).3,4 Because of this, it is often
difficult to determine which stimulus is most responsible for a patient's symptoms and to design a therapeutic plan.
Complications of prolonged or severe nausea and vomiting include esophageal rupture, Mallory-Weiss tears, dehydration,
hypokalemia, hypomagnesemia, hypo- or hypernatremia, metabolic alkalosis, malnutrition and dental caries.
Table 1: Selected Causes of Nausea and Vomiting

CNS Gastrointestinal
Head trauma Appendicitis
Increased intracranial pressure Cholecystitis/cholangitis
Migrainea Gastric outlet obstruction

Gastroparesis
Vestibular disorders (including motion sickness)a
Hepatitis (acute)
Endocrine/Metabolic
Intestinal obstruction
Diabetic ketoacidosis
Nonulcer dyspepsiaa
Pregnancya
Pancreatitis
Renal disease (uremia)
Peptic ulcer disease
Infectious
Miscellaneous
Acute otitis media
Postoperative nausea and vomitinga
Gastroenteritisa
Pyelonephritis Noxious odoursa
Medication/toxin-induceda
a Common causes of nausea and vomiting.
Figure 1: Pathways Involved in Nausea and Vomiting

Motion Sickness
Motion sickness refers to the normal physiologic response to unusual perception of motion.5 It can be precipitated by
abrupt changes in movement, such as during bumpy rides, turbulent flights and rough seas, and is also referred to as
airsickness, seasickness or carsickness. The development of motion sickness depends on a number of factors
including the characteristics of the stimulus (frequency, intensity, direction and duration) as well as individual
susceptibilities including age and gender.5,6,7 Women are more prone to developing motion sickness than men.
Susceptibility to motion sickness is highest between the ages of 3 and 12 years, and gradually decreases thereafter.
Children under the age of 2 years are typically immune to motion sickness. Motion sickness begins with a feeling of
“stomach awareness,” followed by nausea, increasing malaise, pallor and sweating. As symptoms worsen, patients
may also experience increased salivation, a feeling of body warmth, dizziness and vomiting or retching.5,6,7 The
severity of symptoms varies with the intensity of the stimulus and the susceptibility of the individual.
Theories of the cause of motion sickness centre around a mismatch between the motion one expects to occur (either
through visual cues or previous experiences) and the actual motion sensed by the vestibular apparatus in the ear.5,7
The vertical component of the motion is believed to be most important in causing motion sickness, and the
movement must be repetitive, relatively slow, and prolonged.5 This may explain why ship travel, characterized by low-
frequency continuous heaving, is such a potent cause of motion sickness while travelling in a speedboat is not.
Neurotransmitters thought to be most responsible for motion sickness include histamine and acetylcholine. Drugs
used for treatment are aimed at modulating receptors for these chemicals.
Postchemotherapy Nausea and Vomiting (PCNV)
Nausea and vomiting associated with chemotherapy are divided into 3 types: acute, delayed and anticipatory.
Whether acute or delayed nausea and vomiting is experienced depends most strongly on the actual chemotherapy
drug(s) administered and their dosage and infusion rate.4,8,9,10
Acute PCNV:
Starts within a few hours after chemotherapy administration and usually does not persist beyond 24 hours
Occurs in >90% of patients receiving highly emetogenic chemotherapy regimens (e.g., cisplatin,
cyclophosphamide)9,10
Patient-related risk factors include younger age, female sex, past history of low alcohol intake, poor control of
symptoms in prior cycles and history of motion sickness or nausea in pregnancy9,10
The neurotransmitter most responsible is serotonin (5-HT3 receptors) while type 2 dopamine and neurokinin-1
receptors also play a role9,10
Chemotherapy and radiation therapy cause enterochromaffin cells lining the GI tract to release serotonin in large
amounts, activating 5-HT3 receptors in the GI tract, which stimulate the vomiting centre in the medulla oblongata
(Figure 1).9,10
Delayed PCNV:
Begins at least 24 hours after administration of chemotherapy and may last up to 6 or 7 days9
Cisplatin and cyclophosphamide are the most commonly used drugs that cause acute as well as delayed
nausea and vomiting, often with a nausea and vomiting–free period in between. With cisplatin, the incidence of
delayed nausea and/or vomiting may be as high as 80%4,9,10
Serotonin is less important in delayed nausea and vomiting, while substance P-dependent mechanisms appear
to play a significant role.11
Anticipatory vomiting:
Is a conditioned or learned response to previously poorly managed nausea and vomiting in chemotherapy
patients
Occurs in approximately 25% of patients by the fourth course of chemotherapy12
Occurs before, during or immediately after chemotherapy administration but before acute nausea and vomiting
would be expected to occur.
Nausea and Vomiting of Pregnancy (NVP)
Also known as “morning sickness,” nausea and vomiting of pregnancy occurs in 70–80% of pregnancies.13 These
symptoms are normal in pregnancy. While the underlying pathophysiology is not well understood, a combination of
processes is likely involved including genetic, endocrine, environmental, gastrointestinal and psychosocial
factors.13,14 Other theories suggest evolutionary adaptation where NVP serves to protect mother and fetus from
ingestion of foods that might potentially be dangerous.15 Meat, fish, poultry and eggs (all of which carry the risk of
infectious diseases) produce the most aversion in North America. Morning sickness is less common in societies that
do not eat such foods.15 Experiencing NVP is associated with better pregnancy outcomes, including a lower risk of
miscarriages and preterm deliveries.13,16,17
Virtually all women who develop NVP have some symptoms by 9 weeks' gestation, and more than half have
symptoms by 6 weeks.18 For the vast majority of women, the symptoms subside by 16 weeks; however,
approximately 10% of women have NVP that persists beyond 20 weeks' gestation. Nausea and vomiting may occur at
any time of day and be constant throughout the day.
Hyperemesis gravidarum is a serious condition occurring in up to 2% of pregnant women.18 It is characterized by

intractable vomiting, beginning in the first trimester and possibly continuing throughout the pregnancy. Vomiting may
lead to dehydration, electrolyte disturbances, nutritional deficiency and weight loss. This condition can threaten the
survival of the fetus and the mother, and requires early identification and treatment. Such symptoms must also
prompt investigation for specific diseases such as urinary tract infections, diabetic ketoacidosis, thyrotoxicosis and
hepatitis.18 Hyperemesis gravidarum is typically diagnosed when other possible causes of nausea and vomiting have
been ruled out.
Postoperative Nausea and Vomiting (PONV)
Postoperative nausea and vomiting, defined as nausea and/or vomiting occurring within 24 hours following surgery,
occurs in up to 70–80% of patients at high risk (e.g., female sex, nonsmoker, history of PONV or motion sickness, use
of nitrous oxide, use of intraoperative and postoperative opioids, high doses of neostigmine, longer duration of
surgery).19,20 Nausea and/or vomiting may be present in the recovery room immediately following surgery or may
begin several hours later. The cause of PONV is thought to be multifactorial, with individual, surgical and anesthetic
risk factors. Four primary risk factors are well recognized: female sex, nonsmokers, history of PONV/motion sickness
and opioid use.19 In one study, the incidence of PONV in the presence of none, 1, 2, 3 and all 4 risk factors was 10%,
20%, 40%, 60% and 80%, respectively.21 Longer duration of surgery and the type of surgery also influence the
incidence of PONV. Intra-abdominal surgery, ophthalmic surgery (particularly strabismus), gynecologic surgery and
ear-nose-throat surgery are associated with higher rates of PONV.1,19 Furthermore, even if the absolute risk of PONV
is low with a particular surgery, aggressive prevention of nausea and vomiting might be preferred if the effects of
PONV have a high likelihood of causing undesirable surgical complications as seen in some cosmetic procedures
with tight suture lines. In terms of anesthesia, nitrous oxide has been associated with an increased risk of PONV, and
volatile anesthetics are strongly associated with nausea and vomiting in the early postoperative period (within 0–2
hours). Besides the obvious unpleasantness for the patient, PONV can sometimes result in overnight hospital stays
when day surgery was planned, interfere with pain management efforts, lead to wound dehiscence if vomiting or
retching occurs following abdominal procedures, or result in fluid and electrolyte imbalances.
Almost all of the known mechanisms for nausea and vomiting (dopaminergic, serotonergic, cholinergic,
histaminergic, cortical) may be active to varying degrees in patients who experience PONV.1,19,22
Medication-induced Nausea and Vomiting
Almost all medications are capable of producing nausea and, to a lesser degree, vomiting. Some of the most
commonly used and/or emetogenic nonchemotherapy drugs are listed in Table 2.
The mechanisms by which some drugs cause nausea and vomiting are unknown but likely involve extensions of their
pharmacologic action. Drugs that cause vomiting by acting on the area postrema include dopaminergic agonists
(e.g., levodopa), nicotine, digoxin and opioid analgesics. Agents such as NSAIDs and erythromycin activate peripheral
afferent pathways, most likely vagal, which then stimulate the brainstem nuclei to coordinate the act of vomiting. This
chapter specifically addresses opioid analgesics.
Opioid-induced nausea and vomiting:1,23,24
Approximately 25–30% of patients started on opioids experience nausea

Nausea and vomiting are most common during the first few days of therapy and tolerance develops rapidly
thereafter
There is little evidence of differences between opioids in their propensity to cause nausea and vomiting. Rather,
the increase in the dose of opioid raises the risk of nausea and vomiting
Opioids may cause nausea and vomiting by stimulating afferent input into the vomiting centre, via the vestibular
apparatus, the cerebral cortex or the chemoreceptor trigger zone.
Table 2: Commonly Used Drugs that Frequently Cause Nausea and/or Vomiting
Antibiotics: Antidiabetics:
Antituberculous agents Metformin
Erythromycin Sulfonylureas
Sulfonamides Cardiovascular:
Tetracycline Amiodarone
Anticonvulsants: Beta-blockers
Carbamazepine Calcium channel blockers
Phenobarbital Digoxin
Phenytoin Procainamide
Valproic acid Others:
Anti-inflammatories: Acyclovir
ASA Levodopa
Auranofin Nicotine
Colchicine Opioids
NSAIDs Oral contraceptives
Theophylline
Goals of Therapy
Eliminate nausea and vomiting
If not possible, then reduce severity, frequency and duration as much as possible
Prevent complications of nausea and vomiting
Prevent recurrence of nausea and vomiting
Decrease time off work and lifestyle disruptions caused by nausea and vomiting
Reduce or prevent side effects of medications used to treat nausea and vomiting
Patient Assessment
Figure 4 presents an approach to patient assessment for nausea and vomiting.25 Table 3 presents symptoms of
dehydration.26,27 Figure 2 depicts decreased skin turgor.
General nonpharmacologic measures for managing nausea and vomiting include eating small meals, avoiding spicy
foods and noxious odours and reducing physical activity. If pain and nausea coexist, successful treatment of the pain
often reduces the nausea.
Maintaining fluid intake helps prevent dehydration and electrolyte disturbances. The amount of fluid required depends on
the amount lost through vomiting and/or diarrhea. Normally, 2.5 L of fluid intake is required to maintain water balance.26
In patients who are vomiting several times daily, 3–5 L of water per day may be needed. For mild dehydration, drinking
adequate amounts of water may be all that is required. To treat moderate to severe dehydration, it is necessary to replace
electrolytes (especially sodium and potassium). Oral rehydration solutions with appropriate amounts of electrolytes are
recommended under these circumstances.27
Motion Sickness
To prevent motion sickness, counsel patients to:
Avoid eating a large meal within 3 hours of travel

Avoid dairy products and foods high in protein, calories or sodium before travel
Avoid alcohol, smoking and disagreeable odours
Avoid visual stimuli that commonly precipitate motion sickness, such as reading and watching videos during
travel
While travelling, focus on a stable external object or the horizon
While on a boat, stay in a central location least susceptible to motion
While in a vehicle, sit in a front seat with a clear forward view, and, if possible, drive the vehicle rather than be a
passenger
Increase ventilation and exposure to cool fresh air
Minimize head movement by pressing head into headrest.
Acupressure wristbands (Sea-Bands) have not been shown to be beneficial for preventing motion sickness.28,29 In a
controlled study of experimental motion sickness, neither acupressure nor acustimulation were of benefit.30
Although potent antiemetic medications are usually required in patients receiving highly emetogenic chemotherapy,
hypnosis reduces anticipatory nausea and reduces the amount of antiemetic medication required in both children and
adults.31,32
Other behavioural manoeuvres aimed at producing relaxation, diverting attention and enhancing feelings of control
may be effective, particularly for anticipatory nausea and vomiting.
Although not well studied, the following measures may be recommended to reduce NVP:
Eat small, bland, frequent meals and avoid fatty, fried or spicy foods13,14
Eat at times of the day when nausea is less severe18,33
Eat before getting out of bed in the morning to help early morning nausea
Try cold food if the smell of hot food is bothersome
Avoid cooking if possible
Drink small amounts of fluid regularly between meals.
Prenatal vitamins may worsen nausea, primarily due to the iron content as well as large size of tablets. In the first
trimester, women can take folic acid alone or a multivitamin that does not contain iron.34
In patients with frequent vomiting, maintenance of fluid and electrolyte status orally or intravenously is essential.
Acupuncture and P6 acupressure have been the subject of numerous trials for NVP. P6 is also known as Nei Guan
(“inner guard”) and is the sixth point along the pericardial meridian. P6 is anatomically located about 5 cm proximal to
the distal crease of the wrist, between the tendons of palmaris longus and flexor carpi radialis of either forearm
(Figure 3). The point can be stimulated with the tip of a finger, with or without moderate-pressure massaging. There is
no consensus regarding how long or how often to apply the pressure, but some practitioners recommend 5 minutes
of pressure every 4 hours.33 Patients may be taught to do this themselves. Wearing Sea-Bands continuously is an
alternative, but some studies (in motion sickness) have shown less efficacy than manual pressure because the Sea-
Bands tend to slip out of position. Some patients find them too conspicuous. Studies evaluating the effectiveness of
acupuncture or acupressure at P6 have shown equivocal results.35,36,37 While acupressure has not been clearly
shown to be better than dietary or lifestyle advice or “dummy” acupressure, the manual application of acupressure is
harmless and without cost.
Reassure patients that most mild to moderate forms of nausea and vomiting are normal, not harmful to the fetus and
usually subside as the pregnancy progresses.
Table 3: Symptoms of Dehydration in Children and Adults

Children Adults
Decreased urination (less than 4 wet diapers in 24 Feeling weak or light-headed

h)
Sunken eyes Dry mouth/tongue
Greyish skin
Decreased skin turgor (Figure 2)
Figure 2: Decreased Skin Turgor
When pinched and released, the skin flattens slowly.

Figure 3: P6 Acupressure Point
General measures that may be useful in preventing PONV include avoiding significant intake of food for 48 hours
postoperatively, slow and gradual increase in physical activity postoperatively, avoiding noxious odours and stimuli
and maintaining adequate hydration. Smooth transportation of the patient from the postanesthetic recovery room to
the ward is also important. Comfort measures such as cool cloths and sucking on ice chips may be beneficial.
Low quality evidence suggests that P6 acupressure may be as effective as antiemetics in preventing and treating
PONV.38,39,40,41
Gastrointestinal Products: Antiemetics; Vitamin and Mineral Products: Single Entity.
Selected agents used in the management of nausea and vomiting are described in Table 5.42,43,44 For further discussion
of pharmacologic therapy for nausea and vomiting, consult the Compendium of Therapeutic Choices: Nausea in Adults.
For treatment of nausea and vomiting associated with viral gastroenteritis there is no evidence that one antiemetic is
superior to another. The initial choice should be made on the basis of previous response, available routes of
administration, cost, adverse effects and patient preference. These criteria often result in dimenhydrinate being tried
first.
If symptoms are worsened by movement, it may be surmised that acetylcholine is a significant contributor and
anticholinergic agents such as dimenhydrinate may be tried first. If symptoms are associated with a feeling of fullness in
the stomach, a prokinetic agent such as metoclopramide or domperidone may be a logical starting point. Caution is
warranted with these agents since domperidone is associated with a small increased risk of serious ventricular
arrhythmias or sudden cardiac death and metoclopramide is associated with extrapyramidal symptoms (even in children)
and tardive dyskinesia (involuntary movements of the tongue, face, mouth or jaw). If patients fail to respond to these
initial measures, selection of other antiemetics is based on adverse effects, available routes of administration, patient
preference and cost. Consider trying agents with different mechanisms of action if combinations of antiemetics are to be
used.
Motion Sickness
Since acetylcholine and histamine are thought to be the most important neurotransmitters causing motion sickness,
it follows that anticholinergic and antihistaminergic drugs are fairly effective in controlling it. Prevention is more
effective than treatment in established nausea and vomiting.
For short duration of exposure, dimenhydrinate is effective for most patients. Diphenhydramine is an
alternative. Because motion sickness induces gut stasis, it is important to take oral medications at least 60
minutes in advance6,7
Scopolamine transdermal patch applied at least 4 hours before exposure is effective and superior to placebo,
and has the advantage of a longer duration of action45
Promethazine has a longer duration of action as compared to dimenhydrinate and may be an alternative in
patients with refractory nausea or when dimenhydrinate is ineffective
If alertness is required, transdermal scopolamine or oral promethazine have been combined with
dextroamphetamine or ephedrine.45,46 These combinations have been used in extreme situations (e.g., by airline
pilots) after the patient has become thoroughly accustomed to their CNS effects, as these may be
unpredictable47
The most appropriate agent for children older than 2 years is dimenhydrinate given 1 hour before exposure, then
every 6 hours as needed. Diphenhydramine may also be used as an alternative and may help children sleep
better while travelling. Some children experience paradoxical excitability with these agents, so a test dose
should be administered well before travelling
Controlled clinical trials have not consistently demonstrated the benefit of ginger root for motion
sickness,48,49,50 although it is widely promoted for its antinausea effects.
Since dimenhydrinate is recommended by Canada's Motherisk program for augmenting doxylamine/pyridoxine

(Diclectin) therapy in pregnancy34 and it is considered generally safe in pregnancy, it can be considered for
intermittent therapy of motion sickness in pregnant patients. Promethazine may also be used.34
Effective agents are available for the treatment and prevention of PCNV (e.g., 5-HT3 receptor antagonists, neurokinin-
1 antagonists, dexamethasone). For further discussion of pharmacologic therapy for postchemotherapy nausea and
vomiting, consult the Compendium of Therapeutic Choices: Chemotherapy-induced Nausea and Vomiting.
When nonpharmacologic methods fail to control nausea and vomiting, medication can play a role in relieving
symptoms and preventing weight loss, dehydration and hospitalization. In patients with hyperemesis gravidarum, the
combination of intravenous fluids and antiemetic drugs is often necessary. For further discussion of pharmacologic
therapy for nausea and vomiting of pregnancy, consult the Compendium of Therapeutic Choices: Nausea in Adults.
Treatment of nausea and vomiting of pregnancy:
Diclectin, containing 10 mg each of pyridoxine (vitamin B6) and doxylamine, is the drug of choice for NVP in
Canada34,35,51
Pyridoxine alone may safely reduce NVP and may be used in place of Diclectin in women who prefer a “natural”
remedy or in whom doxylamine is not tolerated14,35
Dimenhydrinate is both safe and effective for NVP. Typically, this agent is second-line therapy after Diclectin has
been tried. Other agents that appear to be safe in pregnancy and can be used in women who do not respond to
Diclectin or dimenhydrinate include chlorpromazine, prochlorperazine, promethazine, metoclopramide and
ondansetron14,34,35
Evidence suggests that ginger is effective in reducing NVP in divided doses of 500–1500 mg/day.35,52,53 In a
systematic review of randomized controlled trials, 4 of the 6 trials showed ginger was superior to placebo, and in
the other 2 trials it was as effective as vitamin B6.52 Safety concerns have been raised regarding the presence of
natural cytotoxic chemicals in ginger. However, based on available data there appear to be no significant adverse
effects on pregnancy outcomes if the daily dose is limited to 1 g.
Treatment of postoperative nausea and vomiting:
The most effective strategy to manage PONV is to reduce risk factors when appropriate.19,22,23 Whenever
possible, regional anesthesia should be used in place of general anesthesia, intravenous propofol should be
used in place of nitrous oxide and volatile inhaled anesthetics, and nonopioid analgesics (e.g., NSAIDs) should
be used in place of opioids. Prophylaxis of PONV should be reserved for patients who are at moderate to high
risk (≥2 risk factors or a history of PONV)
Appropriate preventive therapies include 5-HT3 receptor antagonists, dexamethasone, droperidol and, to a lesser
extent, prochlorperazine. In a meta-analysis of 18 trials, dimenhydrinate was found to be an effective antiemetic
for prophylaxis of PONV when compared with placebo.54 Transdermal scopolamine also may be effective,55 but
should be applied the evening before surgery or 4 hours before the end of anesthetic action. Limitations of
transdermal scopolamine include its slow onset of action and adverse effect profile. Because numerous
neurotransmitters are involved in the pathogenesis of PONV, combination therapy is more effective than
monotherapy.19 Drugs with different mechanisms of action may be used when necessary. Combination therapy
with 5-HT3 receptor antagonists and droperidol or dexamethasone is equally efficacious56,57
Treatment of established PONV has not been thoroughly studied, but available evidence and experience support
the use of the following agents as needed postoperatively: 5-HT3 receptor antagonists, promethazine,
prochlorperazine, droperidol and dexamethasone. When prophylaxis with one drug has failed, a repeat dose of
this drug should not be initiated as rescue therapy and a drug from a different class of antiemetics should be
used19,58
Although data are limited, treatments such as peppermint oil or isopropyl alcohol aromatherapy have reduced
PONV.59,60
Opioid-induced Nausea and Vomiting
Therapeutic options for opioid-induced nausea and vomiting include:
Alter the administration schedule so that nausea does not interfere with meals
Reduce the dose of the opioid as low as possible or avoid large increases in the opioid dose since this may lead
to comparatively large increases in the opioid's serum concentrations, which may in turn induce or worsen
nausea and vomiting
If pain is not controlled, attempt an increase in dosage since nausea is sometimes caused by pain
Consider switching to another opioid at 75% of the equivalent daily dose. No solid evidence for differences
between opioids exists in terms of emetogenicity, but patient responses are highly variable24
Addition of an antiemetic drug is often helpful, although the possibility of additive CNS side effects must be
carefully weighed. Appropriate antiemetic agents include metoclopramide, diphenhydramine, dimenhydrinate,
prochlorperazine, promethazine, haloperidol and the 5-HT3 receptor antagonists23,24
When managing refractory opioid-induced nausea and vomiting, instead of replacing one antiemetic agent with
another, adding additional therapies with different mechanisms of action may result in a synergistic effect
Tolerance to nausea and vomiting frequently develops in patients receiving opioids for chronic pain. However,
changes to the opioid drug therapy regimen should be made as part of a team approach, closely involving the
patient's other healthcare practitioners.
Efficacy
For all of the conditions discussed in this chapter, monitoring therapy involves paying close attention to the patient's
description of the nausea response, changes in frequency of vomiting and vigilant monitoring for emergence of
serious complications such as weight loss, dehydration, changes in mental status (which may signal electrolyte
disturbances) and blood loss from any source. Assess adherence to nonpharmacologic measures when response to
therapy is suboptimal (see Table 4).
Table 4: Monitoring of Therapy for Nausea and Vomiting

Pregnancy-associated Patient: Continuously Minimal/no nausea. Diclectin might be
nausea Healthcare practitioner: helpful if
Day 3 dimenhydrinate or
pyridoxine do not
provide adequate
relief after 3 days of
therapy.
Pregnancy-associated Patient: Continuously Vomiting does not interfere Diclectin might be

vomiting Healthcare practitioner: with daily activities and helpful if
Day 3 does not result in other dimenhydrinate or
morbidity (dehydration, pyridoxine do not
weight loss, electrolyte provide adequate
disturbances). relief after 3 days of
therapy.
Motion sickness Patient: Whenever Minimal/no nausea. Depending on the

exposed to stimulus No vomiting. drug being used,
Healthcare practitioner: increase dosage or
After next visit switch to another
agent; ensure dose
given approximately
60 min before
stimulus.
Postoperative nausea Patient: Continuously for Minimal or no nausea, no If dimenhydrinate

and vomiting 72 h after surgery vomiting during 48 h ineffective, other
Healthcare practitioner: postoperative period. agents may be tried.
For 72 h after surgery
Opioid-induced nausea Patient: Continuously Minimal or no nausea. If dimenhydrinate

and vomiting Healthcare practitioner: No vomiting. ineffective,
Daily or as often as is alternative agents
practical may be tried and/or
opioid dosage may
be adjusted.
Symptoms of Patient: Continuously No symptoms of If symptoms of

dehydration (Table 3) Healthcare practitioner: dehydration. dehydration occur,
Daily or as often as is further evaluation
practical would be required
immediately.
Safety
Table 5 shows the most common adverse effects encountered with the antiemetic agents discussed. If a patient
experiences an intolerable adverse effect, consider dosage reduction, switching to another agent or relying on
nondrug measures alone. Reassess patient if PONV persists beyond 48 hours postoperatively. The most common
cause of nausea and vomiting >48 hours postoperatively is opioid analgesics.

Advise all patients with nausea and vomiting regarding:
When medical attention should be sought (warning signs include symptoms of dehydration such as dizziness and
sunken eyes, severe abdominal pain, blood in vomitus, repeated vomiting and inability to keep liquids down for >8
hours)
Nonpharmacologic measures to improve nausea and vomiting, tailored to the specific cause in their case
Possible adverse effects of drug therapy, especially sedation, which may preclude performing activities requiring
mental alertness such as driving or operating dangerous machinery
The risk of combining antiemetic medications with alcohol
The importance of handwashing after handling the scopolamine patch, as severe eye irritation or mydriasis can
occur if the eyes are touched.
Resource Tips
Motherisk web site: www.motherisk.org.
Motherisk Morning Sickness Helpline: 1-800-436-8477.
Algorithms
Figure 4: Assessment of Patients with Nausea and Vomiting
Abbreviations: N&V = nausea and vomiting
Drug Table
Table 5: Nonprescription Pharmacologic Therapies for Nausea and Vomitinga
Class Drug Dosage Adverse Effects Drug Costb
Uses/Onset Interactions
Anticholinergics scopolamine Adults: 1 Motion Sedation, Sedatives, $$

Transderm V patch sickness constipation, anticholinergics
applied to Onset: 4 h dry mouth, (additive
skin every 72 blurred vision, effects).
h if required. rash, allergic
Should not contact
be used in dermatitis, eye
children. irritation if
Caution in hands touch
elderly. eyes after
handling patch.
Disorientation,
delirium. The
elderly are at
increased risk
of CNS effects.
Antihistamines dimenhydrinate Adults: 50– Motion Sedation, dry Alcohol and any $
Gravol 100 mg Q4- sickness, mouth, other
Preparations, 6H PRN po NVP, PONV constipation, medication that
generics (maximum Onset: 30 urinary causes
400 mg/day) min retention, drowsiness
Children 6– blurred vision, may enhance
12 y: 25–50 paradoxical sedative
mg Q6–8H excitation in effects of the
PRN po children. antihistamine,
increase
Children 2–5 confusion,
y: 15–25 mg ataxia and
Q6–8H PRN paradoxical
po excitation.
Antihistamines diphenhydramine Adults: 25– Motion Sedation, dry Alcohol and any $
Benadryl, 50 mg Q4– sickness, mouth, other
generics 6H PRN po NVP, PONV constipation, medication that
(maximum Onset: 30 urinary causes
200 mg/day) min retention, drowsiness
Children 6– blurred vision, may enhance
12 y: 12.5– paradoxical sedative
25 mg Q4– excitation in effects of the
6H PRN po children. antihistamine,
increase
confusion,
ataxia and
paradoxical
excitation.
Class Drug Dosage Adverse Effects Drug Costb
Uses/Onset Interactions
Phenothiazines promethazine Adults: All types Sedation, Alcohol and $

Histantil Motion Onset: 30 somnolence, other CNS
sickness: 25 min extrapyramidal depressants
mg BID po symptoms, dry (additive
with first mouth, effects).
dose 30–60 constipation,
min before blurred vision.
departure
and repeat
dose in 8–12
h PRN
PONV: 12.5–
25 mg Q4–
6H PRN po
Children ≥2
y: Motion
sickness: 0.5
mg/kg
(maximum
25 mg/dose)
po with first
dose 30–60
min before
departure
and repeat
12 h later
PRN
Vitamins pyridoxine Adults: 10– NVP Abdominal pain, No significant $

(vitamin B6) 25 mg po Onset: 1–2 headache, loss drug
TID h of appetite, interactions.
paresthesia,
photosensitivity,
skin irritation,
somnolence.
a
For more information on pharmacologic management of nausea and vomiting, consult the Compendium of Therapeutic Choices:
Nausea in Adults.
Abbreviations: NVP = nausea and vomiting of pregnancy; PCNV = postchemotherapy nausea and vomiting; PONV = postoperative
nausea and vomiting
Legend: $ <$1 $$ $1–2
Suggested Readings
Einarson A, Maltepe C, Boskovic R et al. Treatment of nausea and vomiting in pregnancy: an updated algorithm. Can Fam
Physician 2007;53:2109-11.
Gan TJ, Diemunsch P, Habib AS et al. Consensus guidelines for the management of postoperative nausea and vomiting.
Anesth Analg 2014;118:85-113.
Jordan K, Gralla R, Jahn F, Molassiotis A. International antiemetic guidelines on chemotherapy induced nausea and
vomiting (CINV): content and implementation in daily routine practice. Eur J Pharmacol 2014;722:197-202.
Murdin L, Golding J, Bronstein A. Managing motion sickness. BMJ 2011;343:d7430.
Swegle JM, Logemann C. Management of common opioid-induced adverse effects. Am Fam Physician 2006;74:1347-54.
References
Ostomy Care
Marie Berry, BScPharm, BA, LLB

Types of Ostomies
An ostomy is an artificial opening made surgically in the body. The opening itself is called a stoma, derived
from the Greek word stoma, meaning mouth. A colostomy involves the colon, an ileostomy the ileum or
small intestine and a urostomy the urinary tract. Ostomies may be permanent or temporary, and the type of
ostomy used depends upon the condition being treated.
Half a million North Americans have ostomies and over 90 000 ostomy operations are performed each year
in the United States and Canada.1 No particular age or ethnic group has more ostomies, but in general more
women than men have ostomies. Birth defects account for the majority of ostomies in children.
The older the adult the more likely the ostomy surgery will be a colostomy because of cancer or obstruction
related to disease. Ileostomies are more common in young women, especially those resulting from
inflammatory bowel disease.
Ileostomy
To construct an ileostomy, the entire colon and possibly part of the ileum are removed or bypassed.
Usually the ileum end is brought to the skin surface.
For some persons, instead of an ileostomy the surgeon creates a continent fecal diversion, such as an
ileoanal reservoir (“S” or “J” pouch). In this procedure, a permanent external ostomy bag is not needed.
The entire colon and rectum are removed and the ileum is refashioned into an internal pouch with the
end of the ileum joined to the anal canal. The internal pouch serves as a reservoir which is able to store
waste material that then can be eliminated in the normal way.
Crohn's disease and ulcerative colitis are the most common reasons for an ileostomy. An ileostomy may
also be required because of trauma, cancer, familial polyp disease or necrotizing enterocolitis.
Colostomy
To construct a colostomy, part of the colon is removed and the GI tract ends with a portion of the colon.
The different types of colostomy are illustrated in Figure 1. A colostomy may be required due to
obstruction of the colon or rectum, genetic malformation, trauma, radiation colitis, loss of anal muscle
control, diverticulitis, or cancer of the colon or rectum. Colorectal cancer is the most common indication
for this procedure.
Temporary ileostomies and colostomies are sometimes performed to allow a diseased or surgically
repaired bowel to heal, and once the bowel has healed it is reversed.
Colostomies and ileostomies show a characteristic output or effluent, as described in Table 1.
Table 1: Description of Output from Different Colostomies and Ileostomies

Ileostomy Initially the output is liquid. With time, as the ileum
becomes more absorptive, the output becomes
semi-soft. The output is continuous and contains
enzymes that may cause skin irritation but is less
odourous than output from a colostomy. An
appliance must be worn at all times.
Ascending colostomy (uncommon) The output is liquid or semi-solid, malodourous

and irritating. An appliance must be worn at all
times.
Transverse colostomy (commonly used The output is semi-solid, malodourous and

for temporary colostomies) irritating; an appliance must be worn at all times.
Descending and sigmoid colostomies Output is pasty. Irrigation may be an option and an
(more common) appliance may not be needed.
Figure 1: Types of Colostomies

Urostomies
Urostomies (urinary diversions) are most common in infants and the elderly. They are performed to
correct bladder loss or dysfunction resulting from genetic malformation, cancer or neurogenic bladder.
These allow the elimination of urine through an opening in the abdominal wall. Because urine always
remains liquid and is discharged continuously, urostomy surgery usually requires an appliance. There are
many types of urostomies (see Figure 2):
Ileal and colonic conduits (more common): The colon or (more commonly) ileum is used to fashion
the conduit into which the ureters are implanted. Mucus shreds may be seen in urine because the
bowel has been used. Urine output from the stoma is continuous and an appliance is required at all
times.
Ureterostomy (uncommon): The ureters are brought to the skin surface; with time the ureters tend
to narrow.
Nephrostomy: A tube is placed into the renal pelvis of kidney to divert urine from the kidneys. It may
be temporary in the case of reversible ureteral obstruction.
Cystotomy: A suprapubic cystostomy is a surgically created passage from the abdominal wall
directly into the urinary bladder. A catheter tube is then inserted into the bladder to continuously
drain urine.
Continent urinary diversion: A pouch is created using the small or large bowel and is emptied by
intermittently inserting a catheter in the stoma. Some examples are the Kock, Indiana, Florida or
Miami pouches. In the Mitrofanoff procedure, the appendix is used to create the conduit and a
stoma is constructed that can be intermittently catheterized. A passage is created with a reservoir
valve to channel from the urinary bladder to the abdominal skin. No external collection pouch is
required.
Orthotopic neobladder, i.e., Studer pouch, is a new or neobladder constructed from intestine to
replace a diseased or dysfunctional urinary bladder. The detubularized bowel segment is surgically
attached to the urethra. No stoma is present and it is possible to void normally through the urethra
but some persons may require urethral catheterization.
Figure 2: Types of Urostomies

Patient Assessment
A healthy stoma is shiny, moist and either dark pink or red (see Photo, Healthy Stoma). It has no pain
sensation because it does not contain nerve fibres. The stoma size in adults usually ranges from 2–5 cm
depending upon the portion of the bowel or urinary tract used. After surgery, it shrinks gradually over several
months to its permanent size.
A careful history and inspection of the ostomy site can help determine whether the patient is experiencing a
problem. See Common Problems section for more information.
Photo 1: Healthy Stoma

Convatec
Goals of Ostomy Care

Contain output or effluent
Prevent common problems such as skin irritation
Minimize impact of ostomy on activities of daily living and optimize quality of life
Appliances and Accessories

Ailments—Ostomy Products: Adult Appliances; Pediatric Appliances; Protectants, Adhesives and Cleansers.
Appliances
An appliance is used to collect output from the stoma but not all stomas require appliances. The ideal
ostomy appliance permits effective containment with no leakage, does not damage skin and is odour-
free.
An ostomy appliance includes the pouch, which collects output, and the skin barrier with a flange (plastic
ring on the skin barrier that attaches to the pouch) or adhesive coupling system. The skin barrier
attaches to the skin on the person's abdomen (Figure 3). Appliances are available in both pediatric and
adult sizes.
Figure 3: Placement of a Two-piece Ostomy Appliance

Pouch
Pouches (see Figure 4) are available in different lengths and capacities to contain the varying
amounts of output. Pouches may be open-ended (drainable) or close-ended (not drainable). Whether
a drainable or non-drainable pouch is selected depends upon the site of the stoma, the consistency
of the output and whether the task or cost of emptying and cleaning the pouch is acceptable to the
individual. Open-ended appliances afford frequent emptying and are more often used for ileostomies
and when a colostomy is not regulated. It is usually recommended that pouches are emptied when
they are half to a third full. If a drainable pouch is used, the drainage end needs to be kept clean.
Pouches are selected based on the individual's choice and their ability to care for the ostomy.
Pouches come in various lengths, can be clear or opaque and some may have a fabric backing for
comfort or discretion. Most pouches are odour proof and some have an embedded charcoal filter to
minimize odour while allowing gas to escape.2
Flange
The flange is the plastic ring on the skin barrier that attaches to the pouch. The selection of the
flange size depends upon the size of the stoma. Skin barriers with flanges are also available in
different sizes, shapes (e.g., round, oval) and convexities, and in rigid or flexible formats to
accommodate different body contours and stoma sizes, shapes and locations.
One-piece vs. Two-piece Appliances
Appliances are available as both one- and two-piece units (Figure 4).
One-piece appliances combine a pouch/skin barrier and attach directly to the skin. Closed-ended
appliances are discarded after one use while open-ended versions can be emptied and reused until the
skin barrier requires changing. Two-piece appliances consist of a skin barrier with a flange, which is
attached directly to the skin and separate pouches. The benefits of using a two-piece appliance include:
pouch can be cleaned for reuse, and less frequent removal/replacement which can irritate the skin.
While this ability to interchange appliance components exists within a manufacturer's line of products, it
does not usually extend between various manufacturers. Of note, two-piece appliances can be difficult to
use if a person has diminished manual dexterity or eyesight.
Figure 4: Ostomy Appliances

Accessories
Skin Barriers
Skin barriers help keep the skin surrounding a stoma intact, protecting it and keeping it dry. Skin
barrier wafers are usually composed of pectin, gelatin and cellulose. The skin barrier wafer can be
flat, convex, rigid or flexible to accommodate different body contours and stoma sizes, shapes and
locations. Stomas that drain urine or loose/liquid stool require special barriers commonly labelled for
“extended wear”. Flanges are incorporated in skin barrier wafers and are an essential component of
the ostomy appliance. If the person has a confirmed allergy to any of the components of the product
it would be best to test the skin barrier before using it. Applying the product to an inconspicuous area
of skin for 48 hours is usually sufficient to determine whether there is any reaction.
Skin barrier powders are formulated of pectin, gelatin and cellulose and used to absorb moisture
from the skin. Skin barrier pastes are also formulated of pectin, gelatin and cellulose and contain
alcohol and preservatives. They are used like caulking, to improve the seal between the skin barrier
wafer and the skin on the abdomen. Skin barrier paste is also available in strip format that is alcohol-
free.
Adhesives
Although no longer in common use, adhesives are applied either as cement, which must be allowed
to dry before the appliance is attached, or as a pad. Some adhesives include skin barriers in their
formulations. Some ostomy pouches have adhesive integrated into the flange and/or skin barrier,
making application simple.
Adhesives are the most common cause of allergies. A patch test should be performed prior to use as
described in Skin Barriers.
Other Accessories
Sometimes adhesive tape is used to secure an appliance. If so, it should be hypoallergenic.

Belts are often used by urostomy patients to reduce the strain on the skin barrier wafer from the
weight of the urine in the pouch. However, any ostomy patient can use a belt to assist with
improved wear and to decrease the risk of leakage.
Solvents are available to remove adhesive residue, but they are drying and should be used
sparingly and washed off thoroughly.
Ostomy pouch covers prevent rustling, provide discretion during intimacy, and may prevent skin
irritation due to rubbing or perspiration.
Appliance Fit
Note: Measurement of the stoma and fitting an appliance are beyond the scope of this chapter and should
be performed only by individuals with specialized training in this area.
The correct appliance fit is paramount. A fitting guide is usually included with each box of appliances to help
determine the correct size based on the stoma. An appliance with an opening smaller than the stoma may
cause abrasion of the stoma and poor wearing time. If the opening is larger than the stoma, skin excoriation
can result. Other considerations in choosing an appliance include body contour, stoma location, presence of
skin creases and scars, and type of ostomy.3 Obesity can be a problem in fitting and maintaining an
appliance.
The type of appliance may change postsurgically as the stoma heals, and as body contour changes due to
weight changes, aging, pregnancy or concurrent medical conditions.
Changing the Appliance

Routine emptying of the pouch is required, usually when it is about one-third full. This would help prevent the
weight of the pouch from compromising the seal on the skin.
The directions for changing the appliance vary somewhat from model to model and the directions
accompanying the particular pouch should be consulted. However, some general principles do apply:
Hands should be washed before beginning.

The appliance should be carefully peeled off to avoid damaging the skin.
The stoma and peristomal skin should be gently washed with warm water and soap, then thoroughly
dried.
Soap must be completely washed off.
Alcohol should not be used to clean the peristomal skin.
All adhesive areas should be in contact with skin.
All skin folds should be smoothed out.
Once applied, the appliance should be pressed gently into place.
Irrigation
For some persons with colostomies, irrigation is sometimes an alternative to wearing an appliance. It is less
expensive and affords some control of fecal outflow. In irrigation, squirting water through the stoma into the
intestine stimulates peristalsis which forces waste out. It is usually performed in the bathroom with an
irrigation bag, which is much like an enema bag.
In addition to an irrigation bag, irrigation systems include an irrigation sleeve, skin barrier and stoma cone.
The stoma cone is used with its pointed end inserted into the stoma to act like tubing, but to prevent bowel
perforation, which could accompany the use of tubing alone. The irrigation sleeve, attached to the skin
barrier, carries the waste material to the toilet.
When not being irrigated, a stoma cap or even a pad is all that is required to cover the stoma. Irrigation is
performed regularly, the interval ranging from every one to four days. A convenient time may be after the
largest meal of the day, because of the peristalsis stimulated by the meal.
Common Problems
Common problems usually involve the stoma or peristomal skin. The actual incidence of skin problems is
difficult to determine; however, peristomal skin problems seem to occur frequently involving anywhere from
18–55% of persons living with an ostomy.4,5 Functional, psychological and social factors may contribute to
ostomy problems. Poor manual dexterity, visual problems, clothing incompatibilities and dietary issues can
lead to appliance leakage and odour. Other concerns, such as depression, anxiety, sexual or body image
concerns, lack of education about the stoma and inability to return to work, can exacerbate any problem.
Peristomal Skin Problems
Allergies
Skin barrier adhesives and pastes are the most common cause of allergies, and allergic contact
dermatitis is the most common manifestation (itching, burning or stinging, redness and areas of
moist, denuded skin).6 A switch to another adhesive or appliance may be necessary. A skin barrier
may help, but it needs to extend beyond the damaged area. The majority of modern appliances are
latex-free, reducing the risk of a latex allergy.
Infections
Infections can occur under the skin barrier and/or flange. These may be bacterial or fungal; culture
and sensitivity testing may be needed to identify the pathogen responsible and ensure appropriate
treatment. Proper maintenance is important in preventing infections.
Ostomy sites are susceptible to fungal infections with Candida species because they provide a warm,
moist environment conducive to fungal growth. The primary symptom of Candida infection is itching,
accompanied by a red rash with satellite lesions.7 With an unchecked infection, skin excoriation and
additional skin irritation can occur. Use of broad spectrum antibiotics can contribute to Candida
infections by changing the normal flora; thus, knowing a patient's medication history is important.
Nystatin powder may be used to treat Candida infections. The appliance is applied directly over the
powder, with any excess powder brushed off. Another antifungal option is the silver based Arglaes
powder. Usually antifungal powder is continued for 1 week after the Candida infection clears.
Treatment may be extended further if the individual is also undergoing treatment with antibiotics.
Greasy topical products should be avoided since they may interfere with the adherence of skin
barriers.
Refer any person living with an ostomy to an appropriate healthcare practitioner (e.g., wound ostomy
and continence nurse, enterostomal therapy nurse, physician) if experiencing symptoms of infection,
fever, chills, foul odour or purulent output from the stoma.
Skin Damage
The most common peristomal skin problem is sore skin, usually the result of frequent removal of the
appliance. The skin around the stoma becomes damaged—red, swollen, burning, itchy. Skin damage
may be also related to mechanical irritation caused by a poor-fitting appliance, a stoma that is
difficult to access or clothing that is too tight.
Skin Excoriation
Skin excoriation or irritant dermatitis is abrasion of the skin by digestive enzymes, which may result
in bleeding, painful skin (see Photo, Peristomal Skin Excoriation). The most common cause is an
appliance that is too big for the stoma and allows leakage. Delayed replacement or maintenance may
also result in waste material containing digestive enzymes coming into contact with skin. Choosing
the proper size of appliance, routine maintenance of the appliance, and use of a skin barrier will avoid
the problem.
Photo 2: Peristomal Skin Excoriation

Convatec
Folliculitis
Folliculitis is an inflammation of hair follicles around the stoma and is characterised by redness at
the base of hair follicles. Aggressive removal of an appliance may also pull hair from follicles,
resulting in inflammation and infection. Shaving the area surrounding the stoma will prevent
folliculitis. An electric razor is preferred because it will leave the skin intact. Clipping the hair is an
alternative if shaving with an electric razor does cause skin damage.
Leakage
Ill-fitting or badly applied appliances result in leakage around the seal. Proper fit and maintenance of the
appliance are the solution to this issue.
Bleeding
Bleeding of the stoma is usually due to aggressive cleaning. Proper cleaning technique is required—
gentle yet thorough. If bleeding persists, it may be an indication that the original disease has recurred, or
that a new condition is developing. Referral to an appropriate healthcare professional is necessary.
Odour
Diet is the most common source of odour. Identifying what food is causing the odour and changing the
diet usually solves the problem (Table 2). Pouches usually have an odour barrier and thus are considered
odour-free, provided they are changed regularly, emptied as needed, cleaned properly, are without flaws
or pinholes and are reliably sealed. Emptying a pouch is often accompanied by odour.
Deodorants are available to help control odour. These are placed into the pouch after each emptying.
Oral deodorants, such as activated charcoal, chlorophyllin copper complex and bismuth subgallate, act
on the digestive system to eliminate odours from digested foods.
8
Table 2: Foods with Implications for Ostomy Patients
Bulk-forming foods Celery, coconut, coleslaw, foods with seeds or kernels (e.g., corn),
dried fruits, nuts, meats in casings, popcorn, whole grains, whole
vegetables, wild rice
Gas-forming foods Beer, broccoli, brussels sprouts, cabbage, carbonated drinks,

cauliflower, corn, cucumbers, dairy products, dried beans,
mushrooms, onions, peas, radishes, spinach, string beans or
chewing gum with an open mouth
Diarrhea-causing foods Broccoli, beer (other alcoholic beverages are not common
offenders), green beans, highly seasoned food, raw fruit, spinach
Odour-forming foods Asparagus, beans, broccoli, cabbage, eggs, fish, garlic, onions, peas,
some spices, turnips
Gas
Foods that caused gas prior to surgery usually cause gas after surgery. Travel in pressurized aircraft
cabins can cause distention of an appliance. Careful dietary choices and relaxation techniques to reduce
stress due to travel can reduce this distention. Some appliances have charcoal filters—the gas is
released and the charcoal absorbs odours.
Strategies for decreasing gas include:

Using an antacid
Eating yogurt7
Eating slowly and chewing food well (with a closed mouth)
Avoiding drinking from a straw
Avoiding chewing gum
Limiting intake of gas-producing foods, especially prior to social occasions (Table 2).
Crystalline Phosphate Deposits
Crystalline phosphate deposits may build up on urostomies, making the stoma fragile and cutting into
the mucosa. These deposits are the major cause of blood in a urostomy pouch. To dissolve the crystals,
vinegar mixed with one-third to two-thirds water can be dabbed on the stoma when the appliance is
cleaned. Acidifying the urine by consuming foods such as cranberry juice or even ascorbic acid will
reduce the formation of these deposits. An ammonia odour may be the first sign of this problem and
some individuals monitor the urine pH with urine dip sticks.
Fluid and Electrolyte Depletion
Persons living with an ileostomy lack normal reserve capacity for absorption of water, sodium and
potassium, and should be advised to take extra fluid and electrolytes after exercise and in hot weather.
Specialized fluid and electrolyte replacement drinks used by athletes are ideal but beverages with high
sugar content should be avoided because they can precipitate diarrhea. Some individuals need routine
potassium supplementation and particular attention should be paid to plasma potassium levels if a
diuretic is used.
To avoid dehydration, fluid intake must be sufficient. This is especially important during illness and for
infants. Signs and symptoms of dehydration and common electrolyte abnormalities are summarized in
Table 3 and Table 4.
9,10
Table 3: Symptoms of Dehydration in Children and Adults
Children Adults

Children Adults
Decreased urination (less than 4 wet diapers in 24 h) Feeling weak or light-headed
Sunken eyes Dry mouth/tongue
Grayish skin
Decreased skin turgor
11,12
Table 4: Symptoms of Hyponatremia and Hypokalemia
Hyponatremia Hypokalemia
Nausea, malaise, headache, Muscle weakness, fatigue, shortness of breath, decreased

lethargy, confusion, sensation in arms and legs, abdominal bloating (secondary to
obtundation paralytic ileus)
Constipation
Individuals with colostomies are prone to constipation; fluid, fibre and exercise are recommended to
avoid this problem. The causes of constipation are diverse, but it is often related to medications or diet
(see Constipation). Laxatives should be used only on the advice of an individual's healthcare practitioner.
Diarrhea
Persons with ostomies who are experiencing diarrhea may be at increased risk of fluid and/or electrolyte
imbalances (Table 3 and Table 4). Fluid intake should be increased; oral rehydration solutions may be
used to replenish electrolytes. Foods like bananas, potatoes, pasta, applesauce, yogurt, cheese and
creamy peanut butter can help thicken the stoma output. Refer ostomy patients with diarrhea to an
appropriate healthcare practitioner for further assessment.
Urinary Tract Infections
Individuals with urostomies have an increased risk of urinary tract infections which may require further
assessment and treatment. They should be aware of the symptoms of these infections: chills, fever,
bloody or cloudy urine, foul-smelling urine, back pain in the kidney area, abdominal pain.
Structural Problems
Fistula Formation, Prolapse and Retraction
Fistula formation appears as leakage around the base of the stoma, causing skin erosion. All fistula
formation should be investigated as it may indicate an underlying disease or condition (e.g.,
inflammatory bowel disease, cancer, abscess formation, trauma, foreign body retention). The
underlying problem should be addressed and sometimes surgical refashioning of the stoma is
required.
Inward retraction of the stoma or outward prolapse of the stoma and/or bowel may occur. Either may
be due to the way the stoma was originally fashioned or to major changes in the individual's weight.
Anything that increases abdominal pressure (e.g., coughing, pregnancy) increases the risk of
prolapse. If the bowel is prolapsed, strangulation can occur. A prolapse should be reduced, and
sometimes surgery is required.
Retraction may be controlled by the use of a convex appliance, but as with a prolapse, surgery may be
needed.13
Stenosis
Stenosis is a narrowing of the stoma, usually caused by formation of scar tissue due to the surgical
construction, ischemia, active bowel disease or dermatitis. Dilation and/or surgery may be required
for correction.
Diet
Unless there are medical contraindications, individuals can eat a normal, varied diet, making their own
adjustments to omit foods that change the consistency of the feces or cause odour or gas (Table 2).14 A
food diary may aid in determining foods that are well tolerated and those that cause problems. Fluid intake
is important, especially for individuals with an ileostomy or urostomy. Eight to 10 glasses of fluid each day is
recommended. The foods most often cited as causing odour, gas or frequent watery discharge are brans,
fish, onions, carbonated beverages and beer.
People with an ileostomy will notice that high-fibre foods remain undigested. Sometimes this undigested
food can cause a blockage or obstruction of the stoma. These foods should be introduced into the diet one
at a time. Eating them in small quantities, chewing well and drinking fluids with them will help avoid
problems. Symptoms of obstruction (e.g., no output from stoma, cramping, abdominal pain, vomiting, stoma
swelling and watery, foul-smelling waste material) should be investigated further by an appropriate
healthcare practitioner.
Medication Use
With an ostomy, GI transit times for medications are altered, which may in turn affect the medication's
pharmacokinetics. Extended-release formulations may be unsuitable, and some medications are implicated
in specific complications seen with ostomies, e.g., broad-spectrum antibiotics increase the risk of diarrhea
and fungal infections. Table 5 summarizes some medication concerns.
Table 5: Medication Concerns for Persons with Ostomies

Drugs that may affect ostomy function
Antacids Aluminum-containing antacids can cause constipation in persons with

colostomies; calcium-containing antacids can cause calcium stone
formation in persons with urostomies and ileostomies; magnesium-
containing antacids can cause diarrhea in persons with ileostomies
Antibiotics Broad-spectrum antibiotics may alter the normal flora of the intestinal
tract resulting in diarrhea or fungal infections of the skin surrounding
the stoma. For persons with urostomies, the use of sulfa-containing
antibiotics can lead to crystallization in the urine when high
concentrations are obtained or when the urine is acidic. Persons with a
urostomy that use urinary acidifiers to prevent urinary tract infection or
encrustations are at high risk of sulfa crystal development in the
kidneys or ureters. Persons with urostomies often stop taking urinary
acidifiers while being treated with sulfa-containing antibiotics
Antidiarrheals May cause constipation and possible obstruction in persons with

colostomies
Antimotility drugs May cause constipation in persons with colostomies and in some with
ileostomies
Corticosteroids Immunosuppressants can delay healing and increase risk of infections
Diuretics May cause excess fluid loss and dehydration; with ileostomies monitor
fluid balance and electrolytes
Laxatives May result in perforations of colostomies; stool softeners are preferred;

enemas should not be used with colostomies or ileostomies; avoid
laxatives. Laxatives are also to be avoided in persons with ileostomies
because of the high risk of dehydration and electrolyte imbalance
Opioids May cause constipation
Salt substitutes May cause hyponatremia in persons with ileostomies
Stool softeners May cause diarrhea in persons with ileostomies
Sulfa drugs Crystallization in the kidney may be more prominent if the individual is
having difficulty with fluid and electrolyte balance; more common with
urostomies. Good fluid intake is required
Drugs that may be ineffective because they are poorly absorbed
Vitamins A, D, E, K, B12 Variable absorption can occur with extensive resection of the ileum5
Oral contraceptives May not be adequately absorbed in some persons with ileostomies
Digoxin Variable bioavailability depending on length of bowel
Warfarin Hypoprothrombinemia has occurred in some persons with short bowel

syndrome
Drug formulations that may be problematic
Enteric-coated or timed- Enteric-coated formulations that require the alkaline environment of the
release formulations small intestine to dissolve may pass through the intestinal tract intact.
They are often ineffective in persons with ileostomies and only partially
effective for persons with a colostomy. Checking in the pouch for
undissolved tablets will identify the problem; alternatives include
chewable tablets and liquids. Avoid timed-release preparations,
especially with an ileostomy
Drugs that discolour the Examples: Iron (black), bismuth (greenish black), amitriptyline (blue or
feces green), phenothiazines (pink-red), vitamin B12 (yellow), salicylates (pink
to red or black), senna (yellow), aluminum-containing antacids (whitish
or speckled)
Lifestyle Considerations
Lifestyle Considerations
Persons living with an ostomy can be assured that they can wear their usual clothing and that if the pouch is
changed and emptied as necessary it will not be visible. Women can continue to wear control-top panty
hose, but an elastic girdle may need to be adapted with an opening to prevent pressure on the stoma and
pouch.
Having an ostomy does not necessarily interfere with exercise, sports, occupational work or sexual activity.
However, because of the potential for injury to the stoma, avoiding very heavy lifting and extremely rough
contact sports is recommended. Specialized stomal caps and pouches are available for wear when
swimming. A smaller sized pouch or even emptying the regular sized pouch, along with bathing suits of
patterned fabric or boxer trunks for men, may help an ostomy patient feel more comfortable on the beach.15
Bathing and showering is possible with or without the appliance in place. Soap and water will not injure a
stoma, but bath oils and soaps may leave a greasy film that can prevent the appliance from adhering. If a
long soak in the bathtub is contemplated and the stoma will be below the water line, a cap can be used to
prevent water from seeping into the stoma and the bowel. A person with a urinary stoma who wishes to
attach a night drainage system to their appliance will require a free-standing holder or one that slides
between the box spring and mattress.
Hot weather or physical activity can cause sweating between the appliance and skin which can be
uncomfortable and may lead to skin problems. Some antiperspirants may be used on the skin; however,
check with the individual's nurse or physician. An adhesive change or the use of a breathable skin barrier are
other options. With education, persons living with an ostomy will continue to enjoy their previous quality of
life.
Ensure that persons with ostomies know about:
The surgical technique, resulting stoma position/characteristics and type of output or effluent
The postoperative care with an emphasis on stoma and skin care
What is considered normal and when to contact a healthcare practitioner
Appliance fit, techniques and options
The amount of time an appliance should be worn—scheduling changes may help prevent problems
The available cleansers and deodorants
Recognizing and treating common skin problems
What to do if abdominal changes occur, e.g., weight changes, pregnancy.
Travelling with an Ostomy
It is usually recommended to travel with more supplies than needed and to empty the pouch immediately
before boarding an airplane. Supplies should be protected from the extremes of hot and cold
temperature. For example, ostomy supplies should not be left in the glove compartment of a very hot car.
The changes in temperature, diet and activities that occur during travelling usually decrease the usual
wear times for appliances. Compliance with vehicle seat belt legislation is essential. However, placement
of a seat belt across the appliance or directly on the stoma may cause pressure or friction. To prevent
potential injury place a soft foam padding or a small pillow between the stoma location and the seat
belt. When travelling by airplane, persons with ostomies should carry their ostomy supplies in their carry-
on luggage and ensure they have sufficient supplies.
It is recommended to carry a physician's letter stating that ostomy supplies are required and mentioning
that a private area may be necessary for a search. Currently, for security reasons, most airports prohibit
scissors in carry-on luggage. Scissors, if required, will need to be packed in checked luggage.
Resource Tips
Canadian Association for Enterostomal Therapy. 66 Leopolds Drive, Ottawa, Ontario K1V 7E3. Telephone: 1-
888-739-5072. Available from: www.caet.ca.
Canadian Cancer Society. National Office, 55 St. Clair Avenue West, Suite 300, Toronto, Ontario, M4V 2Y7.
Telephone: 416-961-7223. Available from: www.cancer.ca.
Crohn's and Colitis Canada. 600-60 St. Clair Avenue East, Toronto, Ontario, M4T 1N5. Telephone: 1-800-387-
1479. E-mail: [email protected]. Available from: www.crohnsandcolitis.ca.
International Ostomy Association. P.O. Box 512, Northfield, Minnesota, 55057. Telephone: 1-800-826-0826.
Available from: www.ostomyinternational.org.
Ostomy Canada Society. 5800 Ambler Drive, Suite 210, Mississauga, Ontario, L4W 4J4. Telephone: 1-888-
969-9698. Available from: www.ostomycanada.ca.
Wound, Ostomy and Continence Nurses Society. 1120 Rt. 73, Suite 200, Mount Laurel, New Jersey, 08054.
Available from: www.wocn.org (more suitable for health care professionals).
Suggested Readings
Basic ostomy skin care: a guide for patients and healthcare providers. Mount Laurel: WOCN; 2006.
Dorman C. Ostomy basics. RN 2009;72:22-7.
Floruta CV. Dietary choices of people with ostomies. J Wound Ostomy Continence Nurs 2001;28:28-31.
Hampton BG, Bryant RA. Ostomies and continent diversions: nursing management. St Louis: Mosby Year
Book; 1992.
Patient Education Series. Managing your ostomy. Libertyville: Hollister Inc.; 2003.
A professional's guide for counselling ostomy patients. Princeton: ConvaTec; 1998.
Zanni GR, Wick JY. Ostomy care and the consultant pharmacist. Consult Pharm 2006;21:262-4, 267-70, 272-
4.
References
1. Wound, Ostomy and Continence Nurses Society. Available from: www.wocn.org. Accessed August
31, 2009.
2. Mitchel JV. A clinical pathway for ostomy care in the home: process and development. J Wound
Ostomy Continence Nurs 1998;25:200-5.
3. Rozen BL. The value of a well-placed stoma. Cancer Pract 1997;5:347-52.
4. Colwell JC, Goldberg M, Carmel J. The state of the standard diversion. J Wound Ostomy Continence
Nurs 2001;28:6-17.
5. Rarliff CR, Donovan AM. Frequency of peristomal complications. Ostomy Wound Manage 2001;47:26-
9.
6. ConvaTec Inc. Maintaining healthy peristomal skin. Available from:
www.convatec.com/ostomy/living-with-an-ostomy/skin-care-tips/maintaining-healthy-peristomal-
skin. Accessed February 2, 2016.
7. Bradley M, Pupiales M. Essential elements of ostomy care. Am J Nurs 1997;97:38-45.
8. Chicago Dietetic Association; South Suburban Dietetic Association; Dietitians of Canada. Manual of
clinical dietetics. 6th ed. Chicago: American Dietetic Association; 2000.
9. Canadian Paediatric Society. Caring for Kids. Dehydration and diarrhea in children: prevention and
treatment. Available from: www.caringforkids.cps.ca/handouts/dehydration_and_diarrhea.
Accessed October 25, 2010.
10. JAMA patient page. Preventing dehydration from diarrhea. JAMA 2001;285:362.
Perianal Symptom Assessment
Joyce Chan, BScPhm, MSc, PharmD

Assessment Algorithm
Patients may erroneously attribute any perianal symptom to hemorrhoids. In fact, these symptoms may be due to a
number of conditions, ranging in severity from poor hygiene to colorectal cancer (Table 1).1 An assessment plan for
patients reporting perianal symptoms is illustrated in Figure 1.2,3,4,5,6 All too often, patients seeking relief with
nonprescription agents have delayed consulting a healthcare practitioner until the symptoms have become
unbearable and the condition has advanced to the point where medical referral is necessary.
1
Table 1: Risk Factors for Colorectal Cancer
Age >50 y
History of colorectal cancer or adenomatous polyposis
Family history of familial adenomatous polyposis or hereditary nonpolyposis colon cancer (Lynch
syndrome)
Inflammatory bowel disease
Strong family history (either cancer or polyps in a first-degree relative <60 y or 2 first-degree relatives
of any age)
Figure 1: Assessment of Patients with Perianal Symptoms

a
See Pinworms.
b See Hemorrhoids.
References
1. American Cancer Society. American Cancer Society recommendations for colorectal cancer early detection.
Available from:
www.cancer.org/cancer/colonandrectumcancer/moreinformation/colonandrectumcancerearlydetection/colorectal-
cancer-early-detection-acs-recommendations. Accessed February 18, 2016.
2. Turnbull GK, Vanner SJ, Burnstein M et al. The colon. In: Thomson AB, Shaffer EA, eds. First principles of
gastroenterology: the basis of disease and an approach to management. 5th ed. Toronto: Janssen-Ortho;
2005.
3. Zuber TJ. Diseases of the rectum and anus. In: Taylor RB, ed. Family medicine: principles and practice. 6th
ed. New York: Springer; 2003. p. 776-83.
4. Pfenniger JL, Zainea GG. Common anorectal conditions: Part I. Symptoms and complaints. Am Fam
Physician 2001;63:2391-8.
5. Pfenniger JL, Zainea GG. Common anorectal conditions: Part II. Lesions. Am Fam Physician 2001;64:77-88.
6. Schubert MC, Sridhar S, Schade RR et al. What every gastroenterologist needs to know about common
anorectal disorders. World J Gastroenterol 2009;15:3201-9.
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients. Once
printed there is no quarantee the information is up-to-date. [Printed on: 08-02-2017 12:15 PM]
Pinworms
Joyce Chan, BScPhm, MSc, PharmD

Pathophysiology
Enterobiasis is an intestinal infection caused by the nematode Enterobius vermicularis (commonly
referred to as pinworm, seatworm, roundworm or threadworm).1 Although the adult worms resemble
white cotton threads about 1 cm in length, the name threadworm is best reserved for Strongyloides
stercoralis.
Humans are the only natural host of E. vermicularis. Cats and dogs have been shown to hold eggs on
their fur, probably as a result of dust contamination (e.g., shaking bedclothes in their presence) but there
is no evidence they can act as carriers of the infection.2,3
Transmission of E. vermicularis follows ingestion of mature eggs. The larvae mature in the gut in
approximately 1–2 months. The eggs are not released into the gut contents but the mature female
migrates to the anus at night and lays its eggs on the perianal or perineal skin. The eggs become
infective within 6 hours and are transferred from the perianal region to night clothes, bedding, dust and
air. The most common mode of transmission is on hands and under fingernails, either through
scratching or handling infected clothes and linen.4,5,6 Eggs can remain infective for up to 20 days.5
Pinworms are particularly common in young children 5–10 years of age and uncommon in children
younger than 2 years. An estimated one-third of Canadian children will be infested during their childhood.
It is the most common intestinal parasite seen in the primary care setting, regardless of race,
socioeconomic or cultural circumstances.4,7
Enterobiasis is more prevalent in temperate and cold climates because of less frequent bathing and
infrequent changing of underclothing.3 It is facilitated by factors such as overcrowding in schools and
family groupings as well as inadequate personal and community hygiene. The infestation is more
common in homosexual men, institutionalized patients, residents of native reserves, travellers to areas
of high incidence such as India and Iran, families with school-aged children and primary caregivers of
infected children.2
Despite the high prevalence of pinworms, it is a rather innocuous parasite. The usual consequences of
infection include loss of sleep, discomfort due to anal itching and embarrassment due to the social
connotations of having “worms.” Often an entire family is affected. Only rarely have infections been
associated with significant pathology, including appendicitis, chronic salpingitis and ulcerative lesions of
the small and large intestine.4
Goals of Therapy
Relieve symptoms such as itchiness
Eliminate the infection
Promote good hygiene
Prevent transmission
Prevent reinfection
Patient Assessment
Though many infections are asymptomatic, enterobiasis is often associated with perianal or perineal
itching.4 The itching is worse at night, when the females lay eggs that are attached to the perianal area
by a sticky substance that causes pruritus. The itching may contribute to insomnia and restlessness.
Scratching may cause skin irritation. If severe scratching occurs, the skin may break down and allow
development of a secondary bacterial infection, eczematous dermatitis or bleeding.8 If the worm
migrates to the genital area in females, vulvovaginitis, vaginal discharge and irritation may be seen.9
Enuresis has also been attributed to pinworms.3 Although symptoms may alert the parent or patient to a
potential problem, studies have shown no difference in the incidence of “classic” symptoms between
infected and noninfected children.4 This reinforces the need for actual viewing of the pinworm or its ova
for definite diagnosis (see Diagnosis of Pinworm).
Conditions such as diaper dermatitis, constipation, psoriasis of the anogenital region, and perianal
eczema may mimic symptoms of pinworms and should be considered in patients presenting with
perianal itching.
An uncomplicated pinworm infection does not usually cause abdominal pain, severe diarrhea, bloody
bowel movements, dysuria, fever or extreme poor appetite. If the patient has any of these signs or
symptoms, or if neurotic excoriation (self-inflicted lesions produced by repetitive scratching) or sexual
abuse is suspected, further assessment and medical attention are required.8
Refer all those with suspected pinworm infestation to a physician so the diagnosis can be confirmed.
This is especially important in pregnant women, children under 12 and those with renal or hepatic
impairment.
Diagnosis of Pinworm
Pinworm diagnosis is contingent on visual identification of either the ova or the worm itself.1,4,7 The
3 most common diagnostic methods are:
Inspection of the perianal area:1 parents may observe the worms during ovipositing by putting
the child to bed without underpants and using a flashlight to examine the anus after the child
has been sleeping for 1 hour. Worms obtained by the parents should be placed in alcohol or
vinegar and brought to the clinic for confirmation of the diagnosis.
Scotch-tape test (cellulose-tape slide test):1 this test is performed at home in the morning
before defecation or washing. A piece of transparent adhesive tape is pressed on the perianal
skin, then stuck to a slide to be examined under a microscope. Diagnosis is confirmed by
identification of pinworm ova. The test may have to be repeated several times. A single
examination will confirm the diagnosis in 50%, 3 exams in 90% and 5 exams in 99% of cases.
Microscopic analysis of subungual samples:6 ova may be found under the fingernails of
infected patients since anal itching is a common symptom of pinworm infection.
Prevention
Prevention is difficult. However, proper hygiene is helpful and includes careful handwashing after going
to the toilet, after scratching the perianal area and before and after eating or preparing food.2
As with prevention, proper hygiene is an important component of nonpharmacologic management of
pinworm infestations. If ingestion of eggs can be avoided, the infection is usually self-limiting. In
practice, however, this is difficult to achieve and pharmacologic therapy is usually necessary for
eradication.
Nonpharmacologic measures should always be used as adjunctive therapy in combination with any drug
treatment. These include:
Showering each morning

Regular cleaning of bedding (every 3–7 days for 3 weeks)8
Washing night clothes, underwear and hand towels daily for 2 weeks8
Changing night clothes and sheets frequently and at the start of each treatment course
Handwashing and fingernail cleaning, especially prior to meals and after using the bathroom or
scratching the perianal area
Keeping fingernails short and clean8
During the week following treatment, all family members should wear cotton underpants that have
been washed in hot soapy water. These should be worn day and night and changed twice daily
Cleansing of the floors of sleeping quarters as thoroughly as possible with household cleaner and
water or by airing and vacuuming around beds, curtains and other articles in the bedroom where the
highest concentrations of eggs are likely to occur
Frequent washing of the toilet seat
Avoiding shaking linens or clothing prior to washing
Discouraging thumb sucking.
Cleaning or vacuuming the entire house or washing the sheets every day is probably not effective in
preventing reinfection.
Ailments—Anthelmintic Products.
A confirmed diagnosis by an appropriate healthcare practitioner is recommended before pharmacologic

treatment is initiated to minimize unnecessary exposure to potential adverse effects of the
anthelmintics. Pinworm infections respond readily to drug therapy but reinfection is common.7
Treatment failure is usually due to reinfection.
Treatment with the anthelmintics mebendazole or pyrantel pamoate results in a high cure rate with
minimal side effects (see Table 2).5 Since these anthelmintics do not reliably kill pinworm eggs it is
prudent to retreat 2 weeks later.2,8,10 Since reinfection occurs easily, prevention (e.g., handwashing)
should always be discussed at the time of treatment. Since pinworms can be passed from one person to
another, some experts suggest treating all close contacts of a person with pinworms even if they are
asymptomatic. Treating contacts can help prevent reinfection and the spread of pinworms. This is
especially important in households where more than one member is infected or where repeated,
symptomatic infections occur. However, medical treatment may not be always appropriate for infants or
pregnant or breastfeeding women (see Pregnancy and Breastfeeding). The use of laxatives to facilitate
removal of pinworms after anthelmintic therapy is not necessary.
To relieve the intense itching that often accompanies pinworm infection, a soothing ointment or cream
(e.g., a zinc oxide preparation) can be recommended.
If possible, asymptomatic pregnant women should be treated after delivery since there are no
harmful effects to mother or fetus from the pinworm infection. When a pregnant woman is
symptomatic and natural cure by scrupulous attention to personal hygiene is unlikely, treatment with
mebendazole or pyrantel pamoate may be used after the first trimester (preferably in the third
trimester) on a case-by-case basis.2,11,12,13,14,15
Mebendazole and pyrantel pamoate are considered compatible with breastfeeding.16,17

Table 1 provides a monitoring plan framework, which should be individualized.
Table 1: Monitoring of Therapy for Pinworms

Endpoint of
Symptoms Monitoring Therapy Actions
Perianal itching Parent/patient: Daily Resolution of If itching has not
Healthcare itching resolved within 7–14
practitioner: Day 7 days of starting
medication, repeat
treatment. If itching has
not resolved within 7
days of beginning
second course, or if
signs of bacterial
superinfection occur,
refer to an appropriate
healthcare practitioner
for further assessment.
Adverse effects: Parent/patient: Daily Minimal GI effects If adverse GI effects

nausea, vomiting, Healthcare interfere with
diarrhea, abdominal practitioner: Day 1 functioning or persist
cramps after treatment more than 3 days after
treatment ends, consult
with an appropriate
Adverse effects: Parent/patient: Daily Minimal Caution patient not to

dizziness, drowsiness Healthcare drowsiness or drive or use hazardous
practitioner: Day 1 dizziness machinery until effect of
after treatment drug is known. If
symptoms interfere with
function or persist more
than 24 h after
treatment, consult with
an appropriate

Advise patient regarding:
Proper use of the drug and need for any repeat doses
The need to treat infected family members or close household contacts at the same time (unless
there is a contraindication)
Adjunctive nonpharmacologic measures and proper hygiene
Expected results of drug therapy and management of side effects
The mostly innocuous nature of a pinworm infection
Visiting a healthcare practitioner if symptoms recur.
Drug Table
Table 2: Pharmacologic Therapy for Pinworm Infection
Drug/Costa Dosage Adverse Effects Drug Interactions Comments
Drug Class: Anthelmintics
mebendazole Adults Abdominal pain, Mebendazole may raise No special

Vermox and anemia, diarrhea, risk of Stevens- procedures
children dizziness, Johnson syndrome or such as fasting
$12 ≥2 y: 100 drowsiness, toxic epidermal or bowel
mg single eosinophilia, necrolysis when evacuation are
dose po; flatulence, coadministered with required when
repeat in 2 headache, metronidazole; avoid treating with
wk hematuria, combination. mebendazole.
itching, Mebendazole plasma
neutropenia, levels may be
vomiting. decreased by
carbamazepine or
phenytoin and
increased by
cimetidine.
pyrantel Adults Anorexia, nausea, Pyrantel pamoate and 11 mg/kg base

pamoate and vomiting, piperazine have equals 31.9
Combantrin, children abdominal antagonistic effects; mg/kg pyrantel
generics >1 y: 11 cramps, diarrhea, avoid combination. pamoate.
mg/kg headache, Liquid form (50
$14 (base) dizziness, mg/mL base)
single drowsiness; should be
dose po; transient shaken well
repeat in 2 elevation of before use.
wk aspartate Tablets
Maximum: aminotransferase available as
1 g (base) has been 125 mg
reported. pyrantel base.
Avoid in the
first trimester
of pregnancy.
Caution in
hepatic
impairment.
a Cost of 2 doses based on 70 kg body weight; includes drug cost only.
Suggested Readings
eMedicineHealth by WebMD. Mersch J. Pinworms. Available from: www.emedicinehealth.com.
Kucik CJ, Martin GL, Sortor BV. Common intestinal parasites. Am Fam Physician 2004;69:1161-8.
References
1. Health Canada. Drugs and Health Products. Anthelmintics: labelling standard. Available from:
www.hc-sc.gc.ca/dhp-mps/prodpharma/applic-demande/guide-ld/label-etiquet-pharm/anthelmi-
eng.php. Accessed May 3, 2016.
2. Cook GC. Enterobius vermicularis infection. Gut 1994;35:1159-62.
3. Russell LJ. The pinworm, Enterobius vermicularis. Prim Care 1991;18:13-24.
4. Maguire JH. Intestinal nematodes (roundworms). In: Mandell GL, Bennett JE, Dolin R et al., eds.
Mandell, Douglas and Bennett's principles and practice of infectious diseases. 7th ed. Philadelphia:
Elsevier Churchill Livingstone; 2009. p. 3577-86.
5. Grencis RK, Cooper ES. Enterobius, trichuris, capillaria, and hookworm including ancylostoma
caninum. Gastroenterol Clin North Am 1996;25:579-97.
6. Centers for Disease Control and Prevention. Parasites—Enterobiasis (also known as pinworm
infection). Available from: www.cdc.gov/parasites/pinworm/. Accessed April 1, 2016.
7. Juckett G. Common intestinal helminths. Am Fam Physician 1995;52:2039-48, 2051-2.
8. eMedicineHealth by WebMD. Mersch J. Pinworms. Available from: www.emedicinehealth.com.
9. Centers for Disease Control and Prevention. Laboratory Identification of Public Health Concern.
Division of Parasitic Diseases (DPDx). Parasites and health: enterobiasis. Available from:
www.dpd.cdc.gov/dpdx/HTML/Enterobiasis.htm. Accessed May 3, 2016.
10. Drugs for parasitic infections. Med Lett Drugs Ther 2007;(Suppl):1-15.
11. Tietze PE, Jones JE. Parasites during pregnancy. Prim Care 1991;18:75-99.
12. Van Riper G. Pyrantel pamoate for pinworm infestation. Am Pharm 1993;NS33:43-5.
13. Leach FN. Treatment of threadworm infestation during pregnancy. Arch Dis Child 1990;65:399-
400.
14. de Silva NR, Sirisena JL, Gunaskera DP et al. Effect of mebendazole therapy during pregnancy on
birth outcome. Lancet 1999;353:1145-9.
15. Diav-Citrin O, Shechtman S, Arnon J et al. Pregnancy outcome after gestational exposure to
mebendazole: a prospective controlled cohort study. Am J Obstet Gynecol 2003;188:282-5.
16. World Health Organization. Breastfeeding and maternal medication: recommendations for drugs in
the eleventh WHO model list of essential drugs. Available from:
apps.who.int/iris/bitstream/10665/62435/1/55732.pdf.
17. Centers for Disease Control and Prevention. Parasites—Enterobiasis (also known as pinworm
infection): resources for health professionals. Available from:
www.cdc.gov/parasites/pinworm/health_professionals/.

Pinworms
Pinworms—What You Need to Know
Pinworms are an infection of the intestine caused by a tiny worm. The infection is very common, especially in children.
Pinworms do not usually cause serious problems.
How do you get pinworms?
Pinworms spread easily from one person to another. If one person in a family has pinworms, there is a good chance that
everyone in the family will have them. You may become infected with pinworms if you get pinworm eggs on your hands and
transfer them to your mouth or food.
You cannot see pinworm eggs because they are very small. The eggs can live on sheets, clothing, toys, bathroom walls or
toilets. They also live on an infected person's hands.
What are the signs of pinworms?
A person with pinworms may have a very itchy bottom (anus) or belly pain. They may have trouble sleeping or be irritable.
Many people with pinworms show no signs at all.
How do you treat pinworms?
See your doctor if you think that you or someone you live with may have pinworms. Do not use any medicine until you have an
accurate diagnosis.
If you need medicine, it is important to take the right amount and to follow the directions exactly. Talk to the pharmacist to
make sure you understand the directions. Most people need to take a second dose of the medicine after about 2 weeks to be
sure the infection is gone.
How can you prevent pinworms from coming back?
Everyone in the house should keep their nails cut short.

Everyone should wash their hands and scrub their nails after using the toilet and before eating or preparing
meals.
Wash underwear and sleepwear in hot water every day for 2 weeks to destroy the eggs.
Wear pajamas or pants at night to prevent yourself from scratching while you are asleep.
To stop the spread of eggs, do not shake sleepwear, sheets or blankets before washing them. Fold them up and
wash them right away (in hot water).
Do not use disinfectants to kill the eggs. They do not work.
Infant Nutrition
Joan Brennan-Donnan, BASc, RD

CPhA acknowledges the contribution of Sandra Bjelajac Mejia as a previous author of this chapter.
Breastfeeding
Introduction
Exclusive breastfeeding of infants (defined by the World Health Organization as only breast milk—no solids
and no other liquids, not even water, with the exception of drops or syrups consisting of vitamins, mineral
supplements or medicines) is considered the gold standard for feeding infants for the first 6 months of
life.1,2,3,4 However, the consensus is that breastfeeding continues to benefit the nutritional, emotional and
immunologic health of the child until up to 2 years of age.1,2
Statistics Canada reported that a majority (90%) of mothers in Canada attempt to breastfeed their babies.5
This is higher than the rate of breastfeeding in the United States (77%), but lower than the rates in both
Norway and Australia (95% and 92% respectively).6 However, only 27% of Canadian mothers breastfeed
exclusively for at least 6 months.5 With breastfeeding initiation rates low in some provinces and duration
rates below ideal levels across Canada, healthcare practitioners have a role to play in promotion of this
important preventive health measure.
Peer support groups provide information, practical assistance and emotional support for breastfeeding
mothers using a mother-to-mother approach. These include local La Leche League Canada groups or
breastfeeding classes. Many hospitals offer women breastfeeding support and/or a breastfeeding clinic.
Healthcare professionals can augment this support by ensuring that therapeutic or other interventions, if
possible, allow a mother to maintain the breastfeeding relationship with her baby.7 Problems encountered by
women that may compromise continuation of breastfeeding should be addressed by breastfeeding experts,
who may be public health nurses, dietitians, the mother's physician, La Leche League Canada leaders or
International Board Certified Lactation Consultants (IBCLCs).
Benefits of Breastfeeding
Human milk feeding has acknowledged short-term and long-term benefits including improvement in health
(specifically GI function, host defense and neurodevelopment) as well as social, psychological and
economic advantages.3,7,8 All alternative feeding products are measured against the known benefits of
human milk with regard to growth and development. Research shows that human milk feeding reduces the
incidence and in many cases the severity of a number of illnesses, such as asthma, atopic dermatitis,
childhood leukemia, type 1 and type 2 diabetes, necrotizing enterocolitis, nonspecific gastroenteritis, otitis
media, severe lower respiratory tract infections and sudden infant death syndrome.9 Preterm infants fed
human milk show improved developmental outcomes when compared with formula-fed infants.10,11,12
Although the evidence is not as compelling as for preterm infant data, studies have shown improved
neurodevelopmental outcomes in full-term breastfed infants.13 Further research is needed to clarify any
potential effect on cardiovascular disease, infant mortality, obesity14,15,16,17 and childhood cancers.9,18
For mothers, breastfeeding contributes to a number of health benefits.9 These include decreased
postpartum bleeding and more rapid return to pre-pregnancy uterine size,19 reduced risk of type 2 diabetes,
reduced risk of postpartum depression and a decreased risk of some cancers (breast and ovarian).9,20 The
relationship between breastfeeding and improved bone health21 and more rapid return to pre-pregnancy
weight22 requires further study.9
Contraindications to Breastfeeding
Contraindications to breastfeeding in the mother are few and occur rarely. Breastfeeding might be
contraindicated when the mother:3,23
is HIV antibody–positive
is acutely infected with H1N1 influenza (may resume once afebrile)
has cancer and is undergoing chemotherapy (or tamoxifen treatment for breast cancer24)
has untreated, active tuberculosis (a mother being treated for active tuberculosis can breastfeed if she
is considered noninfectious, i.e., has been treated for at least 2 weeks)
has untreated brucellosis25
has active herpes simplex virus outbreak on her breast
has human T-cell lymphotropic virus (HTLV) type I or II
is taking a drug not compatible with breastfeeding.
Breastfeeding is also contraindicated when the baby has galactosemia, an inborn error of metabolism where
the ability to break down galactose is absent and the baby cannot tolerate breast milk.
Establishing Breastfeeding
Breastfed babies nurse for both food and comfort. Direct skin-to-skin contact between mother and baby
soon after birth can help to establish breastfeeding.26 Pacifiers and artificial nipples may be detrimental to
establishing breastfeeding, and should be avoided if possible.1 Mothers should be encouraged to breastfeed
every 2–3 hours (8–12 feedings in a 24-hour period) during the first weeks postpartum. Educate mothers
about the signs of hunger, satiety and a good latch and letdown. Breastfed babies may seem to be more
wakeful and to feed more frequently, because the components in human milk are easily and readily digested.
Colostrum, the yellowish milk produced in the first day or two is high in nutrients and immunoglobulins.
Because this substance is present in small amounts, the baby is stimulated to nurse frequently, which
establishes an appropriate milk supply. On day 3 or 4 postpartum the milk comes in as the colostrum
changes to mature milk. Milk supply then increases to the individualized quantity required by the baby or
babies in the case of twins or triplets. Removal of milk, through breastfeeding or expressing, acts to increase
production of milk.
Infants who do not readily arouse for feeding should be wakened to feed if more than 4 hours have elapsed
since the start of the last feeding. Signs of adequate intake include 3–5 wet diapers daily by day 3–5, and
4–6 wet diapers daily by day 5–7. After breastfeeding is established, the number of feedings usually
declines to 6–8 every 24 hours.3
Once the mother's milk supply comes in, a well-hydrated, healthy baby will have 3–5 wet diapers and pale,
odourless urine. Brick-coloured crystals in the baby's diaper indicate the infant is not receiving appropriate
amounts of fluid and necessitates referral, especially if the child is under 6 weeks of age. Once the baby's
first stool, called meconium, has passed in the first several days, the breastfed baby will have 2–5 loose,
unformed yellow/green/tan bowel movements per day. After 6 weeks of age the number of bowel
movements and wet diapers may become less frequent. Healthy breastfed infants require no extra water,
even in hot weather, as long as breastfeeding is readily available to the infant.
At ages 3 weeks, 6 weeks and 3 months, it is normal for babies to nurse more frequently for a few days to
increase milk supply to meet their growing needs. By reviewing the signs of adequate milk supply (above),
healthcare professionals can help a mother differentiate a growth spurt from a change in milk supply.
Some mothers may not produce enough milk to maintain their baby's needs. A breastfeeding expert should
assess the problem and initiate counseling, relaxation techniques or mechanical expression. If
nonpharmacologic therapy is unsuccessful, treatment with domperidone 30 mg/day is an option. By
blocking D2 and D3 dopamine receptors in the pituitary gland, domperidone increases prolactin levels and
breast milk production. Potential QT prolongation, ventricular arrhythmias and sudden cardiac death have
been reported when doses of domperidone >30 mg/day are used in patients at risk of sudden cardiac
death.27 Prior to initiation, screen mothers for comorbid medical conditions, the use of QT-prolonging
medications and drugs that may interact with domperidone. Regularly monitor for efficacy and adverse
reactions.27
Fenugreek is a commonly recommended natural health product to increase breast milk supply, although
evidence of its efficacy is minimal.28 The standard dose of fenugreek capsules is 580–610 mg 3–4 times
daily. Fenugreek seeds (one-quarter teaspoonful) may also be steeped in 8 oz (250 mL) of water for 10
minutes to produce a tea, of which the standard dose is 1 cup 3 times daily.
Products that Support Breastfeeding

Ailments—Breastfeeding Products: Collection Accessories, Nipple Accessories, Pumps.
Breast Pumps
A breast pump (Figure 1) may be used to express and store milk when breastfeeding is not possible.
With practice, hand expression is learned. Many types of electric or manual breast pumps are available;
funnels (flanges) are available in various sizes as one size will not suit all mothers.
Figure 1: Breast Pump
Several companies offer a range of electric breast pumps for purchase or rent. Advise mothers to speak
with their local hospital's breastfeeding support clinic for information. Electric breast pumps are most
effective and are recommended when a mother is separated from a hospitalized baby, when the mother
must remove milk quickly and efficiently, or when the baby is unable to nurse (when the mother's breasts
are engorged). Most electric pumps have adapter kits that allow mothers to pump both breasts at the
same time. This increases stimulation, which in turn increases her milk supply and facilitates removal of
milk. The kits can often be turned into manual cylinder or handle-squeeze pumps with the purchase of
adapter parts.
Usually a good quality, manual (hand-operated) pump will suffice for the occasional feed when
breastfeeding is not possible. Bicycle horn–type pumps are not recommended as lack of control on
suction may bruise the breast, and milk can collect in and contaminate the bulb.
Report any instances of breast pumps causing damage or injuring a mother during use to Health
Canada's Medical Device Problem Reporting program. Information may be found at www.hc-
sc.gc.ca/dhp-mps/compli-conform/prob-report-rapport/md_prob_rep-rap_incident_im-eng.php.
Breast Pads
Reusable, washable, cotton breast pads are recommended, as disposable pads with plastic or occlusive
liners promote dampness and increase the risk of a yeast (Candida) infection on the breast. Breast pads
should be changed with each feeding. Mothers should not use cut-up disposable baby diapers, as the
water-retaining beads in the diapers can be harmful to the baby if accidentally ingested. Once
breastfeeding is established, after 6–8 weeks, leaking is not usually a problem.
Nipple Shields
Silicone nipple shields are worn over sore or abraded nipples while the baby nurses, to overcome latch
problems or to help infants with physical challenges or impaired suck mechanisms. Over time, the use of
a nipple shield may lower a mother's milk supply and should be used only on the recommendation of a
breastfeeding expert.
Breast Shells
Breast shells are firm, plastic, cup-shaped devices that can be worn inside the bra between feeds to
provide air flow during healing of an abraded nipple, or to shape the nipple between feeds for easier latch
of the baby. Wearing the shells inside the bra for several hours per day for 6–12 weeks before delivery
may draw out flat or inverted nipples. An estimated 10% of women have nipples that retract rather than
protrude when the areola is compressed. However, proper latch of the baby after birth may overcome this
problem.29 Breast shells are not to be used to collect milk or in place of breast pads. Constant pressure
on the ducts interferes with natural control mechanisms for leaking.
Mother Care
While breastfeeding, a mother should drink to satisfy her thirst and eat according to Canada's Food Guide,
which also recommends supplementation with a multivitamin that includes folic acid.30 For information
regarding galactogogues, see Establishing Breastfeeding.
Nipple Trauma
Nipple trauma is a cutaneous lesion in the area of the nipple and areola manifesting as fissures,
ulceration, erythema, edema, blisters, pain or bruising. Nipple trauma is common among newly
breastfeeding mothers with an incidence ranging from 29–76%.31 The most common cause of nipple
trauma is improper latch of the baby to the breast. Proper latch is attachment that causes no overt pain
and maximizes transfer of milk to baby. Advise a mother with nipple pain to contact a breastfeeding
expert to check the baby's position on the breast. Lanolin, alone or with breast shells, and breast milk
expressed and applied before and after each feeding have demonstrated efficacy in reducing nipple
trauma.31 Applying olive oil before suckling was effective for sore nipples in a preliminary study.32
Irrespective of which treatment is used (including no treatment), most nipple pain subsides to low levels
at 7–10 days postpartum (see Photo, Establishing Successful Latch).33
Photo 1: Establishing Successful Latch

iStockphoto
Thrush (due to the yeast-like fungus Candida albicans) is another common cause of nipple and breast
pain, usually occurring later in the course of breastfeeding. Burning or stabbing pain as well as red, shiny
skin on the nipple and areola are characteristic signs. Prior treatment with antibiotics predisposes
mothers to yeast infections on the breast. If the mother is diagnosed with thrush on the breast, it is
important that both the mother and baby are treated. The mother may use a topical antifungal cream,
e.g., nystatin or clotrimazole (see Fungal Skin Infections). The baby may be prescribed an oral antifungal
medication such as nystatin. Mothers should practise good hygiene to prevent infecting or reinfecting
the baby, or developing a vaginal yeast infection.
Any product applied to the breast or nipple area should be wiped off by the mother before she nurses her
baby.
Sore Breasts
A common cause of pain and swelling of the breasts during the establishment of breastfeeding is
engorgement, typically caused by the arrival of new milk.34 Mild engorgement is normal and reassures
the mother that an adequate milk supply exists. However, if the engorgement is severely symptomatic
and painful, it should be treated. Nonpharmacologic options include applying gentle pressure to the
areola to move the swelling upward into the breast; this helps with the infant's latch. If this does not
enable the infant to latch, manual expression should be tried. Acetaminophen and ibuprofen are also
safe treatment options for the management of breast engorgement.
Mastitis is a painful inflammatory condition of the breast usually resulting from a plugged duct or a
breast infection. A plugged duct occurs when a milk duct does not drain properly and becomes inflamed,
causing soreness, redness and sometimes a lump. Fever and flu-like symptoms may be present as a
result of the inflammation, but may also indicate the presence of an infection. When a plugged duct is
not resolved within 24 hours by increased breastfeeding on the affected side, locally applied heat,
massage and rest, and an infection ensues, an antibiotic must be prescribed.35 Most antibiotics are safe
to use during breastfeeding. Mothers with recurrent mastitis should be referred to a breastfeeding
expert.
Principles of Drug and Natural Health Product Use during Breastfeeding

A mother may continue to breastfeed her baby while on medication depending on whether the benefit to the
mother outweighs the risk of the baby's exposure to the medication. Most drugs are excreted to some extent
in breast milk; however, drugs considered compatible with breastfeeding far outnumber those that are
not.36,37,38,39
The texts Drugs in Pregnancy and Lactation (Briggs and Freeman)40 and Medications and Mothers' Milk (Hale
and Rowe)41 are comprehensive sources of information on drugs and breastfeeding. Knowledge about
safety of medications transferred from mother's milk to baby is evolving. For a selection of reliable and
authoritative web-based resources see Table 1.
Table 1: Online Sources of Information about Compatibility of Drugs and Natural Health Products with
Breastfeeding
Database Web Address (URL)
Drug Use during Breastfeeding www.myrxtx.ca (formerly www.e-therapeutics.ca)
Requires subscription
LactMed—Drugs and Lactation www.toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT

Database housed within the TOXNET Free of charge
web site
Motherisk—provides evidence-based www.motherisk.org

information and guidance about the Free of charge
safety or risk to the developing fetus or
infant arising from maternal exposure
to drugs, chemicals, diseases,
radiation and environmental agents
For more information on pharmacotherapies during breastfeeding, see Prenatal and Postpartum Care and
Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions.
.....
Infant Formula
Introduction
Ailments—Nutrition Products: Infant Formulas.
In both Canada and the United States, regulatory bodies are responsible for ensuring the safety and
nutritional adequacy of infant formulas. In Canada, this responsibility lies with Health Canada under
provision of the Canadian Food and Drug Regulations.
If the mother chooses not to breastfeed exclusively, commercial iron-fortified infant formulas are an
acceptable alternative until 9–12 months of age.
Most infant formulas are available as powder concentrate, liquid concentrate and/or ready-to-use varieties.
Not all products are available in all forms. Powdered formulas tend to be more appealing as they are less
expensive than both liquid concentrate and ready-to-use forms. They are more portable than the liquid
options and the unreconstituted powder does not require refrigeration. Powder formulas are a convenient
option if a mother wishes to supplement breastfeeding.
Once the can is opened, powdered formula can be used for up to 1 month as long as it is stored in a cool,
dry place. It is usually reconstituted with 1 scoop (provided with each product) of powder to 60 mL of boiled
or commercially prepared, sterilized water. Cold tap water should be boiled for at least 2–5 minutes.42 If the
formula will be fed immediately after preparation, it is safe to mix with cooled water that was previously
boiled. However, if the formula is prepared in advance, it should be prepared with boiled water that is still
very hot.1 Once formula made from powder has been reconstituted, it should be covered, refrigerated and
used within 24 hours. Once a feeding has been started, the formula should be used within 2 hours or
discarded.
Concerns have been raised regarding powdered infant formula and its relationship to a number of diseases
including necrotizing enterocolitis and meningitis.43,44,45 Enterobacter sakazakii outbreaks in infants have
been linked to powdered infant formula and the equipment used to prepare it. As a result, regulatory bodies
have issued warnings about the use of powdered infant formula, especially in immunocompromised infants
as well as those born prematurely. It is important to emphasize that proper hygiene, preparation, use and
storage of powdered infant formula minimizes the risks of acquiring E. sakazakii. Bottles, nipples, caps and
any other mixing equipment should be boiled for at least 2 minutes, and allowed to air dry and cool.
Liquid concentrate formulas are sterile and require reconstitution with boiled or commercially prepared,
sterilized water in a 1:1 ratio. Once a can of liquid concentrate is opened, it must be refrigerated and used
within 48 hours. Once mixed with water, the reconstituted formula must be used within 24 hours.
Ready-to-use infant formula is sterile and does not require mixing or the availability of a clean water supply.
Although convenient for the occasional bottle, it is expensive for daily routine feeding.
Infant formulas can be used as a sole source of nutrition or as a supplement to human milk feeding. In
general, commercial infant formulas contain 0.67 kcal/mL with 40–45% of calories from carbohydrate, 8–
12% of calories from protein and approximately 45–50% of calories from fat. Both micro- and macronutrient
content differ slightly between products but all are designed to mimic human milk as closely as possible.
Cow's Milk–Based Formulas

Cow's milk–based formulas are the most commonly used substitution or supplement to breast milk.
The protein content of these formulas is higher than that of breast milk and can vary in the proportion of the
common protein components, whey and casein. Most formula manufacturers try to have the ratio of whey to
casein resemble that of human milk as much as possible. When acidified, whey proteins remain in solution
whereas casein proteins precipitate into curds. Whey-based formulas may accelerate gastric emptying
faster than casein-predominant formulas and may be associated with fewer episodes of emesis or
gastroesophageal reflux.46 The carbohydrate source of standard cow's milk–based formula is either lactose,
the carbohydrate found in human milk, or a combination of lactose and maltodextrin. Maltodextrins are
easily digestible polysaccharides produced from the hydrolysis of starch.
Standard term formulas (for healthy term infants) usually contain a combination of vegetable oils, including
palm, coconut, soy, sunflower and safflower oils. Approximately 50% of the energy contained in a standard
term formula is derived from fat. Although these formulas do contain the essential fatty acids linoleic acid
and alpha-linolenic acid, the fat blends used in commercially available formulas are different from those
found in human milk. Arachidonic acid (ARA) and docosahexaenoic acid (DHA) have been added to some
infant formulas as a few studies suggest that they may improve short-term visual and cognitive function,
although the body of evidence is inconclusive.7,47 Other variations of cow's milk–based formulas include
products with lower iron or with probiotics.
Lactose-free Cow's Milk–Based Formulas

As the name suggests, in these formulas the milk sugar lactose is replaced with either corn syrup solids or
maltodextrin and sucrose. The protein source remains as cow's milk-based protein. Parents may purchase a
lactose-free formula if they suspect that symptoms of gassiness or fussiness in infancy are related to the
lactose content of the formula. Some parents may select this feeding after a bout of infant diarrhea where
there may be a temporary, secondary disaccharidase deficiency. Lactose-free formulas may contain residual
amounts of lactose and galactose, which makes them an inappropriate formula choice for infants with
galactosemia.1 For infants with this condition, see Soy Protein Isolate–Based Formulas.
Lactose has an important role in mineral absorption and nonpathogenic bacterial colonization of the GI
tract. Therefore, a decision to switch to a lactose-free formula should be made with careful consideration of
the risks and benefits.
Soy Protein Isolate–Based Formulas

Soy-based formulas are free of cow's milk protein and lactose. They are iron-fortified and are designed to
meet the nutritional needs of term-born infants. The protein fraction of these formulas is composed of soy
protein isolate. Starch, corn syrup solids, corn maltodextrin and sucrose form the carbohydrate fraction. The
fat blend is the same as the cow's milk–based product of that particular brand. Minerals are added in
greater concentration than in cow's milk–based formula as mineral bioavailability is reduced by the
presence of phytates in the soy protein isolate.
Soy protein formulas are recommended for term infants with galactosemia or congenital lactase deficiency.
They can be used as a supplement to breastfeeding for infants of mothers who follow a vegetarian diet or
for infants whose mothers wish to feed them nonanimal protein-based formula. They are not recommended
for infants with cow's milk protein–induced enteropathy or enterocolitis as 30–60% will also be sensitive to
soy. However, infants who have an immunoglobulin E–associated reaction to cow's milk protein may tolerate
soy formulas.48
Soy formulas contain soy isoflavones, which are phytoestrogens that had been linked to reduced
reproductive function. However, an expert panel did not support this link conclusively.49
The cost of soy protein formulas is comparable to that of milk-based formulas.
Hydrolyzed Protein Formulas

Hydrolyzed formulas available in Canada can be either partially or extensively hydrolyzed. The 2 types
cannot be used interchangeably.
Partially hydrolyzed whey formula contains lactose and is less expensive and more palatable than
extensively hydrolyzed protein–containing formula. Partially hydrolyzed formulas are used commonly as a
substitute for or supplement to breast milk. The perceived benefits of a partially hydrolyzed whey formula,
such as fewer spitting-up episodes and softer stools, are likely related to the β-lactoglobulin (which remains
soluble in the stomach) moving faster to the upper jejunum.50 These benefits may be more pronounced in
children with underlying gastroesophaeal reflux disease.
Extensively hydrolyzed protein-containing formulas contain casein proteins that have been heat-treated and
enzymatically hydrolyzed into peptide chains and free amino acids. They are recommended for infants with
intolerance to intact cow's milk protein and soy protein.51 They contain either long-chain triglycerides or a
mixture of both long-chain and medium-chain triglycerides. The advantages of medium-chain triglycerides
(MCT) in these formulas are their ability to bypass the lymphatic system and their requirement for less
pancreatic enzymes and bile salts for digestion and absorption. Extensively hydrolyzed formulations benefit
infants with malabsorptive diseases such as short bowel syndrome, liver disease, cystic fibrosis and
intractable diarrhea.7 Infants with cholestasis and lymphangiectasia also benefit from extensively
hydrolyzed formulations, especially those containing a higher percentage of medium-chain triglycerides.
Extensively hydrolyzed protein-containing formulas are lactose-free, and the carbohydrate is usually corn
syrup solids, cornstarch and occasionally sucrose. These formulas are more expensive and less palatable
than milk-based formulas.
Infants who cannot exclusively breastfeed and are at high risk of allergy and atopic disease, should be given
extensively hydrolyzed protein formula, which may delay or prevent occurrence.1,51,52
Amino Acid–Based Formulas
Amino acid-based formulas, also known as “elemental” formulas, contain 100% free amino acids. They are
designed for infants with severe milk protein hypersensitivity and are also used for infants with
malabsorption-associated diseases who have persistent symptoms when receiving a partially hydrolyzed
formula. These formulas are lactose-free and usually contain a combination of long-chain and medium-
chain triglycerides. Amino acid–based formulas are more expensive than hydrolyzed formulas and are
equally unpalatable.
Pre-thickened Formulas
Commercially available pre-thickened formulas for the treatment of regurgitation and vomiting offer
advantages over standard formulas thickened with cornstarch or rice cereal. When standard formulas are
thickened with infant cereal or cornstarch, nutrients and fluids are displaced; this practice is not
recommended. The nutrient composition of pre-thickened formulas more closely resembles that of standard
formula. Although symptoms of regurgitation and vomiting have been reduced in infants fed commercially
prepared pre-thickened formula,53 these formulas may not be as effective for reducing reflux symptoms.54
Follow-up Formulas
Follow-up formulas are designed for infants between 6 and 24 months who are consuming some
complementary foods. They are usually less expensive than starter formulas and contain higher amounts of
protein, vitamins and minerals. Although there does not appear to be superior health benefits to using a
follow-up formula compared with a starter formula, they may deter parents from the early introduction of
unmodified cow's milk.
Formulas for Premature Infants

These formulas are designed to meet the accelerated growth needs of infants born prematurely. They are
available in sterile, ready-to-use form and are available only in a hospital setting. These formulations are
available as standard and higher energy (0.67 kcal/mL and 0.8 kcal/mL). The protein, vitamins and minerals
are also present in higher amounts than term formula in order to support third trimester growth. Premature
formulas contain fat blends of 40–50% MCT to improve digestion and absorption in immature GI tracts. The
fatty acids DHA and ARA have been added to all premature formulas in North America based on research
suggesting that there are visual, cognitive and other developmental advantages to supplementing premature
formulas.55,56 Because of the immaturity of the GI tract and lower amount of lactase enzyme, glucose
polymers replace some of the lactose in the carbohydrate portion of these formulas.
Postdischarge Formulas for Preterm Infants

The unique nutritional needs of preterm infants do not end when they reach term age. Many preterm infants
remain undergrown compared with their term-born counterparts. Postdischarge formulas for preterm
infants are designed to provide the additional energy, protein and other nutrients necessary for catch-up
growth. Preterm infants fed a postdischarge formula up to 9 months post-term have higher weights and
lengths compared with preterm infants fed standard-term formula.57 However, little evidence supports using
these formulas beyond 9 months post-term. At standard dilution, these formulas provide 0.74 kcal/mL.
.....
Other Considerations
Alternative Milks and Beverages

Unmodified cow's milk (whole/3.25%, 2%, 1% or skim) and evaporated cow's milk are not recommended
during the first 9–12 months of life. Once introduced, only whole cow's milk should be used until the age of 2
years.58 Cow's milk contains much higher protein content than human milk and limited amounts of the
essential fatty acids linoleic and alpha-linolenic acid. In addition, the renal solute load is higher than that of
human milk due to significantly higher mineral and protein concentrations. This puts a greater stress on the
kidneys especially if the infant has any illness that will increase insensible water loss. Unmodified cow's milk
is also associated with increased blood loss through the GI tract. This blood loss, in addition to the low
concentration and bioavailability of iron in unmodified cow's milk, may predispose the infant to iron
deficiency anemia.7 For more information regarding iron supplementation, see Vitamins and Minerals.
Pasteurized and unpasteurized goat milk, soy beverages, rice beverages or other vegetarian beverages are
not considered complete nutritional alternatives to breast milk or commercial infant formula.
Water and juice are not necessary for breastfed infants during the first 6 months of life and may displace
nutrient-rich human milk and introduce contaminants and potential allergens. Infants older than 6 months
should be offered water if they are thirsty. Sweetened beverages are not encouraged; if consumed, they
should be limited to 125–175 mL per day.58 Carbonated beverages are not recommended for infants
because they contain few nutrients and may contain caffeine and excess sugar, exposing infants to an
unnecessary stimulant and predisposing them to dental caries. As well, carbonated beverages may interfere
with the intake of more nutrient-rich foods. Sports drinks are not recommended for infants because of their
high sugar content and lack of other nutrients. There is a lack of evidence to support the safe use of herbal
teas and drinks in infants and therefore they are not recommended.1
Complementary Foods for Babies Older than 6 Months

Exclusive breastfeeding or an iron-enriched commercial term formula is sufficient to support growth and
development during the first 6 months of life.3 The introduction of complementary foods before 6 months of
age provides no advantage to energy intake, rate of growth or the duration of sleep during the night, and may
displace the intake of human milk or result in less milk production in the mother. Usually around 6 months of
age, when an infant has good head and neck control and shows signs of readiness such as an interest in
food when others are eating, iron-rich foods can be introduced gradually.
In Canada, the most common “first food” is iron-fortified infant cereal. However, other iron-containing foods
(e.g., meats, eggs, tofu and legumes) can be introduced first at this stage and will vary depending on family
and culture.1 Once iron-rich foods are introduced, there is no specific order in which to introduce the infant
to fruits, vegetables and dairy products.58 Initially, foods are introduced in a pureed consistency, but as the
child becomes more mature and confident with new foods, different safe textures should be progressively
introduced until the child is eating a varied diet by the age of 1 year (Table 2).
Delaying common food allergens (egg, fish, peanut, wheat, soy) beyond is not recommended for prevention
of food allergy; it may even increase the risk of developing such allergies.59 Once a potential allergen has
been introduced, it should be regularly fed to the infant several times per week.59 Parents should avoid
introducing more than one common allergen per day, and should separate the introduction of different
allergens by at least 2 days.58 For more information regarding food allergy in infants, see Food Allergy.
Consider the safety of infants when offering complementary foods. While finger foods are encouraged to
promote self-feeding, they should have a low choking risk (e.g., soft fruits and vegetables, grated cheese,
ground meat and toast).58 Avoid hard, small, round and sticky solid foods, raw and undercooked meats and
eggs, and unpasteurized dairy products and juices. Also avoid honey in children under 1 year due to risk of
botulism. Infant consumption of rice products, including infant cereals and toddler snacks, has been
associated with arsenic exposure that exceeds standard recommendations.60 Although the health
implications of increased arsenic exposure are unknown, strategies to limit infants' exposure may be
appropriate; these include feeding with other iron-rich foods, and supplementing the diet with a variety of
grains.
Table 2: Infant Feeding Guide

Age of Infant Breast Milk Iron-fortified Vegetables Meat and Milk Products
or Iron- Infant Cereal and Fruit Alternatives
fortified and Other
Formula Grain Products
Birth–6 Breast milk None None None Breast milk or
months feeding on iron-fortified
demand formula only
every 2–3 h
(8–12
feedings
every 24 h)
Exclusively
and partially
breastfed
infants
should
receive
vitamin D
400 IU/day,
not to exceed
1000 IU/day
Formula
feeding on
demand
every
3–4 h (6–8
feedings
every 24 h)
Exclusive
breastfeeding
or iron-
fortified
infant
formula is
sufficient to
achieve
optimal
growth,
development
and health
until 6
months of
age
6–9 months Breast milk Introduce iron- Offer pureed Introduce Offer plain
Introduce meat, feeding on containing cooked iron-fortified yogurt, cottage
meat demand single food, e.g., vegetables single food, cheese, grated
alternatives Exclusively iron-fortified and/or fruit e.g., meat, hard cheese,
and iron- and partially infant cereal after iron- meat 15–30 mL daily
fortified cereals breastfed Begin with fortified alternative, Breast milk or
as first infants 5–10 mL cereal egg or iron-fortified
complementary should increasing to and/or meat cereal. Iron formula only
foods receive 30–60 mL BID introduced, from meat
vitamin D 120–200 mL sources is
Transition from Introduce other total per day better
runny purees to 400 IU/day, grain products
not to exceed Offer ripe absorbed
thick or finely as than iron
mashed soft 1000 IU/day developmentally mashed fruit
such as from non-
foods Formula appropriate, meat
feeding on e.g., dry toast, banana,
mango, sources
demand, unsalted
usually 3–5 crackers, rice peach, Offer more
feedings and pasta avocado variety of
every 24 h meat and
meat
Ensure alternatives,
introduction e.g., pureed
of solids fish, chicken,
does not tofu, mashed
interfere with beans and
adequate legumes,
volume of 15–50 mL
breast milk or daily
formula
being
consumed
9–12 months Breast milk Offer bread, rice Offer Offer Pasteurized
Transition from feeding on and pasta, mashed or minced, whole cow's
thick or finely demand 120–150 mL diced diced, milk may be
mashed foods Exclusively daily cooked cooked introduced
to minced or and partially Choose whole vegetables, meat, fish, Continue with
diced finger breastfed grain options 100–150 mL chicken, tofu, yogurt, cottage
and table infants daily; soft beans, cheese, grated
foods; should ripe peeled, legumes, hard cheese,
encourage self- receive seeded, egg, 30–60 mL daily
feeding vitamin D diced fresh 50–60 mL
400 IU/day, or canned daily
not to exceed fruits
1000 IU/day packed in
water or
Formula juice, 100–
feeding on 150 mL per
demand, day
usually 3–4
feedings
every 24 h
Transition
from
breast/bottle
to some cup
feeding
Vitamins and Minerals

Ailments—Vitamin and Mineral Products: Single Entity.
Human milk contains small amounts of vitamin D, but not enough to prevent rickets. With decreased sun
exposure, either through the use of sunscreen or coverage of the skin with hats and clothing, the usual
mechanism of vitamin D production is hindered. Dark-skinned infants born to dark-skinned mothers and
infants living in northern climates are at greater risk of vitamin D deficiency.61 All fully and partially breastfed
babies require a vitamin D supplement of 400 IU/day, not to exceed 1000 IU/day.62,63 Vitamin D
supplementation should continue until 1 year of age. Exclusively formula-fed babies do not require
additional vitamin D.1 If direct infant supplementation is not possible, an alternative would be for the
breastfeeding mother to take 6400 IU/day to adequately supply the infant with the appropriate amount of
vitamin D.64
According to the Canadian Dental Association (CDA), fluoride supplements are not recommended before the
eruption of the first permanent tooth.65 Fluoride supplements may be appropriate in communities that do
not have access to fluoride in any other form, such as toothpaste. The CDA Position on Fluorides in Caries
Prevention states “When, on an individual basis, the benefit of supplemental fluoride outweighs the risk of
dental fluorosis, practitioners may elect to use these supplements at appropriate dosages in younger
children. In doing so, the total daily fluoride intake from all sources should not exceed 0.05–0.07 mg
fluoride/kg body weight, to minimize risk of dental fluorosis.”
Healthy, full-term, breastfed infants do not need extra iron until 6 months of age, at which time the iron in
complementary foods provides appropriate intake.1,66,67 Healthy, full-term infants who are not breastfed will
receive adequate iron through iron-fortified infant formula. Infants at risk of iron deficiency include those
with a low birth weight, premature infants, those born to iron-deficient mothers, and infants older than 6
months who drink breast milk or an excessive amount of cow's milk without an adequate supply of iron-rich
foods.1 Symptoms of iron deficiency include pallor, irritability, poor appetite and delayed growth and
development. If iron-deficiency is suspected, the infant should be screened and given supplementation
accordingly.
For more information about Dietary Reference Intakes (DRI) of vitamins and minerals for infants and young
children, see Nutritional Supplements.
Infant Colic
Ailments—Baby Care Products: Gastrointestinal.
Infant colic is defined as periods of fussiness or crying without apparent cause or failure to thrive.1 Possible
causes include immaturity of gut function, altered visceral perception, or, rarely, cow's milk allergy. Although
foods the mother eats may appear in her milk, colic in the baby is seldom the result of the mother's diet.
Therefore, feeding changes (e.g., interrupting breastfeeding, supplementing with formula, restricting the diet
of the breastfeeding mother) are not an effective means to manage infant colic.
Breastfed babies may be fussy for a number of other reasons, such as hunger, the need to be near the
mother, an oversupply of breast milk or an overactive milk ejection reflex. Oversupply or overactive ejection
reflex occur when the mother has a generous milk supply and the baby gets an overabundance of foremilk
(higher in lactose) that overwhelms the intestinal lactase. Consider this condition if a thriving infant presents
with excessive crying, gas and explosive, loose, watery stools. A breastfeeding expert can provide
management techniques. This is not an indication for use of lactose-free infant formula.
For more information regarding infant colic, see Infant Colic.
Gastroesophageal Reflux in Healthy Infants

Gastroesophageal reflux (GER) in healthy infants is a normal physiologic occurrence. Most GER episodes
cause few symptoms and infants gain weight and grow out of their symptoms, without the need for
treatment. However, a subset of infants with gastroesophageal reflux disease (GERD) requires more
aggressive treatment, often as a combination of nonpharmacologic and pharmacologic therapies. Rarely are
the symptoms of reflux so severe that breastfeeding should be discontinued.68 However, if regurgitation and
vomiting persist for more than 1 month in formula-fed infants, the switch to an extensively hydrolyzed
formula or an amino acid–based formula may be warranted.68
Constipation
Stool patterns in childhood vary, ranging from several times per day to once every 3–4 days.1 True
constipation during infancy is rare. When introducing complementary foods such as rice cereal, stool
patterns may change temporarily. Careful attention should be paid to fluid intake to reduce the incidence of
hard, painful bowel movements. For infants older than 6 months, the use of prune juice and the addition of
whole grain cereal, cooked legumes, fruits and vegetables into the diet may be helpful. There are no dietary
fibre recommendations for children under 2 years. Recommendations do exist for children over 2 years69
but are not based on evidence of disease prevention.1 For more information, see Constipation.
Food Allergy
Food allergy is an adverse reaction that develops after an offending food or ingredient is eaten. A true food
allergy is an immunologically mediated adverse reaction which is different from a “food intolerance” (a
reaction not mediated by the immune system).70 Milk, egg and peanut are the most common food allergies
in infancy followed by soy, nuts and wheat. Many food allergies resolve spontaneously with age but peanut,
tree nuts and seafood allergies are less likely to do so. In the majority of children, allergies to milk, egg, soy
and wheat resolve by school age.
Early introduction of peanut-containing foods (4–11 months) may lower risk of developing peanut allergy.71
In infants at high risk of developing peanut allergy (i.e., infants with severe eczema and/or egg allergy),
introduction of peanut-containing food (6–7 g peanut protein per week, equivalent to 2 teaspoons of peanut
butter three times a week) significantly reduced the risk of developing peanut allergy.72 Consider measuring
serum peanut-specific IgE in high-risk infants and based on test results, introduce peanut-containing foods
at 4–6 months [Evidence: SORT B].72 In infants at moderate risk of peanut allergy (i.e., infants with mild to
moderate eczema), consider introducing peanut-containing foods around 6 months [Evidence: SORT C].73
Peanut-containing foods can be introduced in accordance with family and cultural preferences in infants at
low risk of developing peanut allergy [Evidence: SORT C].73 Once peanut-containing foods have been
introduced to the infant’s diet, it should be regularly fed to the infant several times per week. Whole peanuts
and peanut butter directly from a spoon present a choking hazard. Alternatively, peanut butter can be
thinned with warm water or mixed with pureed tolerated fruits or vegetables.
Early introduction of egg-containing food (4–6 months) is also associated with a lower risk of developing
egg allergy.71 It is yet unclear whether a similar association exists between timing of introduction and
subsequent risk of allergy development to milk, fish or wheat.74
The most effective way to manage food allergy is avoidance of the offending food.70 In exclusively
breastfed infants, elimination of the offending protein from the mother's diet is no longer considered a first-
line measure to reduce the likelihood of sensitization, except if the allergen is peanut.51 If allergy is
suspected a mother may continue to breastfeed unless the symptoms are bothersome to her or the baby,
e.g., skin rash, runny nose, diarrhea. If allergies persist, the recommended treatment is to use a formula
containing hydrolyzed proteins. In infants who continue to be symptomatic, an elemental amino acid-based
formula is the only alternative.75 For more information on these types of formulas see Hydrolyzed Protein
Formulas and Amino Acid–Based Formulas. For more information regarding the introduction of solid foods
and food allergy prevention, see Complementary Foods for Babies Older than 6 Months.
.....
Resource Tips
Canadian Lactation Consultant Association. Available from: www.clca-accl.ca
Friedman J, Saunders N. Canada's baby care book: a complete guide from birth to 12 months old. Toronto: The
Hospital for Sick Children; 2007.
International Lactation Consultant Association search tool to find an International Board Certified Lactation
Consultant (IBCLC) from: www.ilca.org/why-ibclc/falc.
Koren G. The complete guide to everyday risks in pregnancy and breastfeeding: answers to all your questions
about medications, morning sickness, herbs, diseases, chemical exposures and more. Toronto: The Hospital
for Sick Children; 2004.
La Leche League Canada. Available from: www.lllc.ca.
La Leche League International. Center for Breastfeeding Information. Available from:

www.llli.org/cbi/CBI.html.
Saunders N, Friedman J, eds. Caring for kids: the complete Canadian health guide for children. Toronto: The
Suggested Readings
Kalnins D, Stone D, Touw J. Better breastfeeding: a mother's guide to feeding and nutrition. Toronto: The
Special Diets
Shirley Heschuk, BScPharm, MSc

Introduction
Some patients require diets that are either restricted or enhanced in certain nutrients for health reasons.1 An appropriate assessment
is necessary to determine whether a special diet would benefit a specific patient.
Sodium-restricted Diet
The purpose of a sodium-restricted diet is to prevent accumulation of fluid and/or promote a net loss of excess body water. The diet
is indicated in:
Essential hypertension: Blood pressure reduction is correlated with a moderately reduced sodium intake.2,3 To decrease blood
pressure, the Canadian Hypertension Education Program recommends reducing sodium intake toward 2 g (5 g of salt or 87
mmol of sodium) per day4 (see also Diets for Cardiovascular Diseases—Diet for Hypertension)
Heart failure: Sodium restriction is the primary diet therapy in treating heart failure. A sodium intake of ≤2–3 g/day is
recommended for all patients with symptomatic heart failure with a further reduction to ≤1–2 g/day for patients with more
advanced heart failure or fluid retention5
Renal disease: Sodium intake should be modified to facilitate blood pressure control, to maintain normal hydration status and to
help prevent heart failure and pulmonary edema. Fluid status and appropriateness of sodium intake can be monitored through
measuring blood pressure, interdialytic weight gains, signs of edema and thirst. In people with chronic kidney disease (CKD),
sodium reduction lowered blood pressure considerably and reduced proteinuria consistently.6 However, long-term studies are
required to determine the effect on mortality and progression to end-stage kidney disease.6 Generally, the recommended intake
of sodium is 2–3 g per day (87–130 mmol)1
Liver disease: In patients with liver disease, fluid and electrolyte status must be monitored and sodium restriction may be
required.
Although sodium reduction is recommended, an aggressive sodium limit of ≤1.5 g/day has not demonstrated a mortality benefit and
may even increase risk of adverse health effects in some populations.7
Choose fresh or frozen food and reduce intake of high-sodium processed food, beverages and condiments, e.g., fast foods, smoked
and/or salted meats, canned or prepackaged foods, snack foods, salad dressings. Limit use of salt in cooking and at the table: use
salt substitutes (KCl) or other seasoning such as herbs, spices, seasoning blends (e.g., Mrs. Dash), lemon juice and garlic during food
preparation. Most salt substitutes contain less than 1 mmol of sodium per teaspoon but large amounts of potassium (30–50 mmol
per teaspoon). Patients with renal disease should not use salt substitutes, as ingestion of additional potassium could result in
hyperkalemia. Note: 2.4 g elemental sodium = 6 g NaCl = 1 teaspoon of table salt.
Advise patients to read the Nutrition Facts table on food packages for sodium content. Sources of sodium include sodium chloride
(table salt), celery salt, garlic salt or onion salt, sea salt, baking soda, baking powder, brine for pickling, soy sauce, substances with
Na (abbreviation for sodium), monosodium glutamate (Accent or MSG), sodium benzoate, sodium citrate, sodium nitrate, disodium
phosphate and sodium gluconate.
Health Canada allows the following sodium-related label claims on food products:
Sodium-free/salt-free = <5 mg sodium per serving

Very low sodium = ≤35 mg sodium per serving
Low sodium = ≤140 mg sodium per serving
Reduced sodium/less sodium = at least 25% less than the regular product
Potassium-modified Diets
The purpose of both high-potassium and low-potassium diets is to maintain normal potassium levels (3.5–5 mmol/L) in hypo- and
hyperkalemic patients.
High-potassium diets may be indicated during use of certain medications such as potassium-wasting thiazide-type diuretics or
antibiotics (e.g., gentamicin). Evidence suggests that a diet with increased potassium may reduce blood pressure and risk of stroke8
and is associated with lower risk of death and cardiovascular events.9
Low-potassium diets may be indicated in patients with impaired renal function or those taking medications that increase potassium
levels, such as potassium supplements, potassium-sparing diuretics and ACE inhibitors. To decrease dietary potassium intake,
restrict fruits and vegetables high in potassium content, such as potatoes, bananas, melons, juices (orange, prune, tomato), spinach,
fresh meat, milk and salt substitutes containing potassium chloride (KCl). Patients who follow a very low potassium diet may
become deficient in calcium, iron, vitamin C, folate and B vitamins.
Fat-restricted Diet
Fat-restricted diets prevent symptoms of intolerance (diarrhea, flatulence, abdominal pain) due to high intakes of dietary fat, and
control nutrient losses caused by malabsorption disorders. Fat-restricted diets are not intended for weight reduction (see Weight
Management) or for lowering serum lipids (see Diets for Cardiovascular Diseases, Diet for Dyslipidemia).
Fat-restricted diets may be used in the treatment of diseases of the hepatobiliary tract (gall bladder disease, chronic cholecystitis),
pancreas (chronic pancreatitis), intestinal mucosa (GERD, Crohn's disease, small bowel resection) and lymphatic system (intestinal
lymphangiectasia).
Those with malabsorption syndromes may be deficient in fat-soluble vitamins and other micronutrients; supplement with vitamins A,
D, E and K. Water-miscible forms of the fat-soluble vitamins are available.
In severe fat restriction, patients may need to supplement protein.
Fibre-modified Diets
Fibre is a substance found in plants that cannot be hydrolyzed by the digestive system. It is classified as soluble or insoluble based
on physiochemical properties. Soluble fibre occurs as pectins (e.g., bananas, apples), mucilage (e.g., psyllium) and gum (e.g.,
oatmeal, legumes). Insoluble fibre includes cellulose (e.g., wheat bran, apples), hemicellulose (e.g., whole wheat) and lignin (e.g.,
potatoes). For a table of fibre content of common foods, see Constipation.
A fibre-restricted diet reduces the frequency and volume of fecal output while prolonging intestinal transit time and prevents
blockage of stenosed gastrointestinal tract. A fibre-restricted diet is indicated in diverticulitis, stenosis of the intestine and acute
inflammatory bowel disease (ulcerative colitis, Crohn's disease) to limit the pain and frequency of stools and to prevent obstruction
when the lumen of the colon is narrowed or stenosed.10
Patients can reduce indigestible carbohydrate intake by limiting amounts of well-cooked or canned vegetables and canned, cooked
or very ripe fruit products, replacing whole-grain breads and cereals with refined products and avoiding nuts, seeds and legumes.
High-fibre diets increase fecal bulk and promote regularity, normalize serum lipid levels and blunt postprandial blood glucose
response.
High-fibre diets are indicated in:
Inflammatory bowel disease: When the disease is in remission or under control, a high-fibre diet (as tolerated) is recommended
to stimulate peristalsis and improve the tone of the muscular wall of the GI tract, especially the colon10
Irritable bowel syndrome (IBS): Research has shown that soluble fibre, but not bran, is effective in treating IBS
11
Colon cancer: A systematic review of dietary fibre intake and the incidence of colorectal cancer concluded a high intake of
dietary fibre, cereal fibre and whole grains in particular, was associated with a reduced risk of colon cancer12
Hypercholesterolemia: Small but significant decreases in total and LDL cholesterol are seen with various soluble fibres13,14
Diabetes: Soluble fibre has a small effect on inhibiting blood glucose absorption from the small intestine15
Cardiovascular disease: Increased fibre intake is associated with a lower risk of coronary heart disease and cardiovascular
disease16
All-cause mortality: For each 10 g/day increase in fibre intake, a 10% reduction in risk of death has been shown.17 Increasing
fibre in patients who survived MI is significantly associated with lower all-cause and cardiovascular mortality.18
Fibre content should be increased gradually to minimize abdominal distress, bloating, flatulence, cramps and diarrhea, and adequate
amounts of noncaffeinated fluid (2 L/day) should be consumed.
Iron-rich Diet
The purpose of an iron-rich diet is to promote adequate intake, especially for individuals with increased iron requirements. It is used
to prevent and/or treat low iron stores and iron deficiency anemia:
For individuals who are at risk for suboptimal iron intake, such as young children and older adults
For individuals with increased iron requirements, such as pregnant women, premenopausal women, endurance athletes or those
consuming a vegetarian or vegan diet.
Iron-rich diets include foods high in iron as well as foods that enhance iron absorption. There are 2 types of iron in the diet:
heme iron, found in meats, fish and poultry, is highly bioavailable (15–35%). Sources include liver (pork, beef and chicken),
venison, beef, clams, oysters, mussels and shrimp
nonheme iron, found in vegetables, is less bioavailable (2–20%). Sources include cooked beans, lentils, chickpeas and
soybeans, pumpkin seeds, tofu, tempeh, blackstrap molasses, enriched breakfast cereals and enriched pasta.
Iron absorption can be increased by consuming iron-absorbing enhancers together with iron-rich foods and by not eating the iron-rich
foods together with foods that inhibit absorption (see Table 1). Cooking with iron skillets, steel woks and stainless steel cookware (to
a lesser extent) may add extra iron to the food.
Table 1: Foods that Affect Iron Absorption

Iron Absorption Enhancers Iron Absorption Inhibitorsa
Meats, fish, poultry Calcium (milk, yogurt, cheese, sardines)

Vitamin C–containing fruits (oranges, orange juice, Eggs
cantaloupe, strawberries, grapefruit) and vegetables Oxalates (spinach, chard, beet greens, rhubarb, sweet
(broccoli, brussel sprouts, tomatoes, tomato juice, potatoes, potatoes)
red and green peppers)
Phytates (whole grains, bran)
Tannins and polyphenols (red wine, coffee, tea)
a Bind to iron and prevent absorption.
Gluten-restricted Diet
Gluten is a protein contained in wheat, rye, barley and triticale (a cross between wheat and rye). In patients with gluten sensitivity,
ingestion causes damage to the mucosa of the small intestine, leading to a variety of GI symptoms (cramps, bloating, diarrhea) and
nutritional deficiencies.
Patients with celiac disease and those who cannot tolerate gluten must follow a restricted diet to eliminate virtually all gluten intake.
Patients must avoid all gluten products (see Table 2); any product entering the digestive system must be gluten-free. It is important
to carefully review ingredient lists on food and drug labels to determine whether gluten-containing ingredients are present. Canadian
regulations permit fortification of gluten-free flours to match the enrichment requirements of white flour for B vitamins, folic acid and
iron, but there is no requirement to do so; additional sources of these nutrients may be required. For gluten content of specific
pharmaceutical products, the manufacturer should be contacted.
Screening tests for celiac disease include either or both of the following blood tests: IgA human tissue transglutaminase (TTG) or IgA
endomysial antibody (EMA). If the symptoms suggest celiac disease and the TTG and/or EMA are negative, the physician should
consider upper endoscopy and intestinal biopsy.
a
Table 2: Selected Gluten-containing Food Ingredients and Substitutions
Ingredients to Avoid Gluten-free Substitutes
(contain gluten)
Barley Amaranth Potato
Beer, aleb Arrowroot Quinoa

Beans Rice
Buckwheat (kasha)c
Corn Sago
Graham
Distilled alcoholic beveragesb Sorghum
Rye
Flax seed Soy
Seminola
Millet Tapioca
Triticale
Nut Vinegar
Vinegar (malt)
(cider or wine)
Wheat (spelt, durum, kamut, semolina, farina) Oatd
a
Includes ingredient and products made from it (e.g., flours); not an exhaustive list.
b
Beer and ale are generally made from barley and contain prolamines, a subfraction of gluten. Alcohol made from fermented grains (e.g., vodka,
whiskeys) is distilled, removing the prolamines; these products are allowed unless otherwise contraindicated.
c
Although buckwheat itself does not contain gluten, some celiac patients cannot tolerate it; also, commercial buckwheat products (e.g., some
buckwheat flours, pancake mixes, pasta) may be mixed with or contain wheat flour.
d
Pure and uncontaminated oats are safe in limited amounts: 50–70 g/day (one-half to three-quarters cup dry rolled oats) for adults and
20–25 g/day (one-quarter cup dry rolled oats) for children with celiac disease.19
Lactose-restricted Diet
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Nutrition
Products: Lactose Digestants.
Lactose is a disaccharide sugar (glucose and galactose) found in dairy products and is digested by the enzyme lactase. A deficiency
of lactase results in lactose intolerance which manifests as intestinal symptoms (bloating, flatulence, cramping, nausea and
diarrhea). The purpose of a lactose-restricted diet is to reduce lactose intake in intolerant patients to a level that will prevent or
reduce these symptoms while providing adequate nutrient intake.
The 3 main types of lactase deficiency are:
Primary: The most prevalent type; presents with a late onset. It usually occurs with increasing age and individuals exhibit
tolerance to various levels of lactose
Secondary: Transient in nature and develops secondary to illness or disease involving mucosal injury
Congenital: Extremely rare and requires a lifelong lactose-free or very-low-lactose diet.
Lactose-intolerant individuals vary in their ability to digest lactose and the amount of lactase in their systems. Total lactose
avoidance is usually not necessary except in galactosemia. True lactase deficiency can be clinically diagnosed with a breath
hydrogen test, which measures hydrogen produced by colonic bacteria in the presence of unabsorbed sugars.
Enzymatic lactase products break down lactose into digestible sugars—glucose and galactose. They are available in various forms:
tablets, chewable tablets and drops.
Lactase-treated food products (e.g., milk, cheeses) and yogurts contain negligible amounts of lactose. Lactose-intolerant individuals
may meet their calcium and vitamin D requirements from other food sources, but supplementation may be required depending upon
their dietary intake and age. For more information on calcium and vitamin D, see Osteoporosis.
Note: It is important to read ingredient lists on food and drug labels, as many fillers contain lactose. For lactose content of specific
pharmaceutical products, contact the manufacturer.
Phenylalanine-restricted Diet
Phenylalanine is an amino acid found in protein which is metabolized to tyrosine by the enzyme phenylalanine hydroxylase. The
absence of this enzyme is the result of a rare genetic disorder called phenylketonuria (PKU). In patients with PKU, phenylalanine can
build up in the blood and brain to toxic levels and affect brain development and function. PKU is detected by a simple blood test
which is part of the newborn screening panel in Canada and the United States and it is treated by strictly following a diet that is
extremely low in phenylalanine, particularly during the years of growth and development.
Phenylalanine is present in significant amounts in high protein foods such as dairy products, meat, fish, chicken, eggs, beans and
nuts. The artificial sweetener aspartame also contains phenylalanine and should be avoided. Special diets devoid of phenylalanine
but containing protein, vitamins, minerals and energy (calories) can be used for life. Foods allowed include: fruit, vegetables, juices,
low-protein breads and pastas. A consult with a dietician is highly recommended.
It is important for patients' progress to be monitored through food diaries, monthly blood tests and regular follow-up care.
Purine-restricted Diet
Purines include the nucleotides adenine and guanine. They are found in virtually all food, but are more concentrated in some (see
Table 3). Purines are metabolized to uric acid, so a purine-restricted diet decreases blood and urine uric acid levels. A purine-
restricted diet is beneficial to patients with hyperuricemia, gouty arthritis and urinary uric acid lithiasis (in conjunction with
medication).
In a 12-year study of men with no gout at baseline, moderate intake of purine-rich vegetables (peas, beans, mushrooms, cauliflower,
spinach) and total protein intake were not associated with increased risk of gout. Higher meat and seafood consumption increased
the risk of gout, whereas consumption of low-fat dairy products reduced the risk.20
Patients with gout should consume meat, seafood and alcoholic beverages in moderation, meet protein needs with purine-rich
vegetables rather than animal products and use low-fat dairy products. Monounsaturated fats and complex carbohydrates are
preferred and portion sizes and the content of noncomplex carbohydrates should be monitored to prevent the development of insulin
resistance.21 For more information regarding dietary recommendations in gout, see Table 3.
Several studies have shown that obese patients are at an increased risk of developing gout.22,23,24 Weight reduction diets that are
high in fat and purine-rich foods such as meat and seafood (e.g., Atkins Diet) can induce ketosis and hyperuricemia. Research is
required to determine the most effective weight loss diet for people with gout.
Table 3: General Dietary Measures for Patients with Gout

Avoid Limit Encourage
Organ meats high in purine content Serving sizes of: beef, lamb, pork, seafood with high purine Low-fat or
(e.g., sweetbreads, liver, kidney) content (e.g., sardines, shellfish) nonfat dairy
products
Avoid Limit Encourage
High-fructose corn syrup–sweetened Servings of naturally sweet fruit juices, table sugar, sweetened Vegetables
sodas, other beverages or food beverages and desserts, table salt (including sauces and
gravies)
Alcohol overuse (>2 servings/day for Alcohol (particularly beer but also wine and spirits) —
males and >1 serving/day for
females)
Adapted with permission from Khanna D, Fitzgerald JD, Khanna P et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1:
systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care and Research 64:(10);1431-46.
Tyramine-controlled Diet
Tyramine is an indirect sympathomimetic amine found naturally in some foods and created when food is cured, aged, fermented or
spoiled. It is metabolized by the monoamine oxidase enzyme and prolongs the action of adrenergic transmitters also metabolized by
this enzyme. Tyramine also stimulates transmitter release from adrenergic terminals which can lead to an adrenergic crisis (sudden
increase in blood pressure and tachycardia), particularly in the presence of monoamine oxidize inhibitors (MAOIs) such as
phenelzine or tranylcypromine.
A tyramine-controlled diet aims to minimize consumption of foods containing tyramine. Patients taking MAOIs follow this diet to
prevent hypertensive crisis and other adverse reactions associated with ingesting MAOIs in combination with tyramine.
Patients limiting their intake of tyramine-containing foods should avoid aged, mature cheeses, dry fermented sausages (salami),
smoked or pickled fish, nonfresh meat or poultry, leftovers containing meat, fish, or poultry, red wine, and overripe, spoiled, moldy or
fermented fruit or vegetables. Cottage cheese and processed cheese are allowed. Cooking food does not reduce the amount of
tyramine it contains.
High-calorie, High-protein Diet

High-calorie, high-protein diets provide energy and nutrients in excess of usual requirements to prevent malnutrition, promote weight
gain, meet the need for increased nutrients and optimize an individual's ability to respond to medical treatment. This type of diet is
indicated for patients with poor intake, e.g., cancer, HIV/AIDS, chronic GI problems, burns, wounds, trauma, renal dialysis, failure to
thrive, preparation for planned surgery.
Calorie-dense and protein-dense foods are suggested, e.g., whole milk, peanut butter, nuts, seeds, beef, chicken, fish, pork and eggs.
Modified Consistency Diets

Table 4 compares modified consistency diets and Table 5 provides a detailed list of foods permitted on a clear liquid diet.
1
Table 4: Comparison of Modified Consistency Diets
Consistency Purpose Indications Description
Clear liquid Supply fluid, electrolytes and For short-term use or transition: Provides adequate water, 500–1000
diet energy in a form that requires In preparation for bowel kcal as simple sugar and some
minimal digestion and surgery or prior to electrolytes. It is fibre-free and
stimulation of the GI tract. colonoscopic examination requires minimal digestion or
intestinal motility. Because of the
After a period of intravenous low calorie and minimal protein
feeding (as a transition diet) content, it is used only for short
In acute GI disturbances periods.
(such as gastroenteritis or For detailed list of foods permitted
pancreatitis). on a clear liquid diet, see Table 5.
Consistency Purpose Indications Description
Full liquid Provide food in a liquid form For patients: Fluids and foods are liquefied using
diet for patients who are unable to Following oral or facial a blender or food processor. The
chew, swallow or tolerate solid surgery. appropriate thickness and
foods. The diet can be temperature will depend on patient
designed to provide adequate With esophageal condition and tolerance. Dairy
calories and protein. abnormalities, e.g., products, soups, eggs and soft
strictures, anatomical cereals are used to supplement
irregularities. clear liquids. Commercial oral
In preparation for some supplements (e.g., Boost, Ensure)
diagnostic procedures. can be used.
Who have been on clear Use of broth, gravy, vegetable juices,
liquid diets for a long time cream soups, cheese and tomato
(to advance the diet). sauces, milk and fruit juices, rather
than water, is recommended to
increase nutritional value, colour
and flavour.
Liquefied foods should be used
immediately, but can be refrigerated
up to 48 h or frozen to prevent
growth of harmful bacteria.
Vitamins and minerals may have to
be supplemented.
Soft diet Provide texture-modified foods To assist in progression Food modified in texture to promote
that require minimal chewing. from full liquid diets to ease of mastication, e.g., chopped,
regular diets in ground, mashed and pureed foods.
postoperative patients. A food processor is recommended
After head and neck surgery. as blenders tend to liquefy foods.
In patients with esophageal Individual patient assessment is
strictures. important to determine the
In patients whose dentition appropriate consistency of food
is too poor to handle a provided. The patient's acceptance
general diet. and tolerance of the diet also dictate
the extent of texture modification.
In other patients who have
The soft diet can be designed to
difficulty chewing or
meet all nutritional requirements.
swallowing.
Most raw fruits and vegetables are
excluded, as are any foods
containing seeds, nuts and dried
fruits. However, soft ripened fruits,
e.g., peaches, pears and bananas
can be mashed to an appropriate
consistency. Vegetables, e.g.,
broccoli, peas, carrots and yams can
be cooked and mashed.
The diet can be modified to comply
with medical nutrition therapy for
specific conditions.
Table 5: Clear Liquid Diet

Type of Food Allowed Not Allowed
Beverages Clear fruit juices, e.g., apple, grape, cranberry All others including nectars, milk, fruit juices
Low-pulp or pulp-free juices, e.g., orange, with pulp, cocoa, prune juice, tomato and
lemonade, grapefruit vegetable juices
Soups Bouillon, consommé or clear broth All others
Sweets/desserts Clear fruit-flavoured or unflavoured gelatin All others and any not tolerated or
Fruit ice made from clear fruit juice contraindicated by medical condition
Plain hard candy, sugar, honey, sugar

substitutes, frozen pops
Type of Food Allowed Not Allowed
Miscellaneous Commercially prepared low-residue, lactose- Regular formulations of nutritional supplements

free nutritional supplements Pepper and spices, all others
Herbs, mild seasonings, salt and flavour
extracts
Meal Replacements and Oral Supplements
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Nutrition
Products: Adult Nutrition Products.
While some meal replacement products are nutritionally complete (e.g., Ensure), others require at least 1 regular meal daily to
meet nutrient requirements (e.g., Boost, Carnation Instant Breakfast).
Oral supplements: Formulated liquid diets are nutritionally complete for oral or feeding-tube use. Some are modified for specific
disease states. A multitude of nutritionally complete formulated liquid diets are available for oral use (e.g., Isocal) or tube feeding
(e.g., Jevity). Elemental liquid formulas (e.g., Vital HN) are useful for patients with difficulties in digestion and absorption as they
are readily absorbed. More specialized formulated liquid diets have been designed to fulfill the nutrition requirements of patients
suffering from certain diseases (e.g., Pulmocare for COPD, Oxepa for ventilated patients).
Diets for Cardiovascular Diseases

For other general principles of healthy living for disease risk reduction, see Lifestyle Management and Disease Prevention. For a
summary of the effects of dietary interventions on surrogate markers of cardiovascular disease, see Table 6.
Table 6: Effect of Dietary Interventions on Metabolic Parameters

Dietary Interventions Advantages Disadvantages
High-carbohydrate (low-glycemic Decreases HbA1c, CRP, hypoglycemia, Non known
index) need for diabetes medications
High-fibre Decreases HbA1c, TC, LDL-C, need for Decreases HDL-C

diabetes medications GI side effects
Low-carbohydrate Decreases TG Decreases micronutrients

Increases renal load
High-protein Decreases HbA1c, BP, TG Decreases micronutrients

Increases renal load
High–omega-3 fatty acids Decreases TG Mercury exposure, environmental

impact
Vegetarian Decreases HbA1c, LDL-C, BMI, TC, Decreases vitamin B12

BP25
Increases HDL-C
Mediterranean Decreases HbA1c, BP, CRP, TC, TG, None known

major CV events, diabetes26, metabolic
syndrome27, mortality28,29
Increases HDL-C
DASH Decreases HbA1c, weight, BP, CRP, LDL- None known

C
Increases HDL-C
Portfolio Decreases LDL30,31

Abbreviations: BMI = body mass index; BP = blood pressure; CV = cardiovascular; CRP = C-reactive protein; HbA1c = glycosylated
hemoglobin; HLD-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; TG = triglycerides; TC = total cholesterol
Diet for Hypertension
Dietary modifications can help to prevent or control primary (essential) and secondary hypertension, alone or in conjunction with
antihypertensive drug therapy.
Reductions in dietary sodium intake can reduce blood pressure.32,33,34,35,36 However, long-term effect on cardiovascular events
and mortality is unclear (see also Sodium-restricted Diet).37 About 50–60% of the population is “sodium sensitive”, with blood
pressure that responds to alterations in dietary sodium intake.38 Sodium-sensitive persons are predisposed to hypertension
because of inherited susceptibility and can benefit most from sodium-restricted diets. African Americans, older adults and
persons with hypertension or diabetes are more sensitive to changes in sodium chloride.39
The Canadian Hypertension Education Program (CHEP) recommendations advise reducing sodium intake toward 2000 mg (5 g of
salt or 87 mmol of sodium) per day to decrease blood pressure.4 CHEP also recommends consuming a diet that emphasizes
fruits, vegetables, low-fat dairy products, dietary and soluble fibre, whole grains and protein from plant sources that is low in
saturated fat and cholesterol.
The Institute of Medicine (IOM) does not recommend an aggressive sodium limit in hypertension; their systematic review
indicates that ≤1.5 g/day of sodium does not confer a mortality benefit and may even increase risk of adverse health effects in
some patient populations.7 The IOM does recommend a moderate reduction in sodium with a limit of ≤2.3 g/day.
The US National Institutes of Health's DASH diet (Dietary Approaches to Stop Hypertension) and Canada's Food Guide are 2
examples of recommendations for healthy eating encouraged by the Heart and Stroke Foundation of Canada. The DASH diet is
promoted to control hypertension; it limits sodium intake, encourages consumption of nuts, whole grains, fish, poultry, fruits and
vegetables, and suggests lower consumption of red meats, sweets and sugar.40 It is also rich in calcium, magnesium, potassium,
protein and fibre. DASH and Canada's Food Guide are similar; Canada's Food Guide has a greater range in the number of servings,
whereas DASH recommends a higher level of vegetable and fruit intake.
Diet for Dyslipidemia
Dyslipidemia refers to high blood levels of low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs) or both, or low blood
levels of high-density lipoprotein cholesterol (HDL-C), all of which contribute to the development of atherosclerosis. Causes may
be primary (genetic) or secondary, which includes excessive dietary intake of saturated fat, cholesterol and trans fat. A modified
diet can improve the lipoprotein and lipid levels of individuals with dyslipidemia and can help prevent and/or slow the progression
of coronary heart disease (CHD).
Lowering total cholesterol and LDL-C decreases risk for fatal and nonfatal coronary events.41 The 2012 Update of the Canadian
Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in
the Adult has established target lipid values based on degree of risk of CHD.
The guidelines recommend the following dietary measures to help achieve these target values:42
moderate energy (caloric) intake to achieve and maintain a healthy body weight
emphasize a diet rich in vegetables, fruit, whole-grain cereals, and polyunsaturated and monosaturated oils, such as omega-
3 fatty acids, particularly from fish
avoid trans fats; limit saturated fats to <7% and total fats to <30% of daily total energy intake
increase daily fibre intake to >30 g
limit cholesterol intake to 200 mg daily for individuals with dyslipidemia or at increased risk of cardiovascular disease
increase consumption of cholesterol-lowering foods such as phytosterols, soluble fibre, soy and nuts
follow any of the following diets: Mediterranean43 (see also Weight Management), DASH (see also Diets for Cardiovascular
Diseases—Diet for Hypertension), or Portfolio (emphasizing cholesterol lowering foods such as soluble fibre, soy protein,
plant sterols and nuts).30,31 See Resource Tips.
Trans fats are formed from the partial hydrogenation of vegetable oils, which turns the oils into solids. Trans fats have been
shown to raise LDL-C levels and decrease HDL-C levels. These fats are often listed as ‘partially hydrogenated oil’ on food labels
and are often found in vegetable oil shortening, hard margarines, commercially prepared baked goods, potato and corn chips,
crackers, microwave popcorn and deep-fried foods. The Heart and Stroke Foundation of Canada states that trans fats are at least
5 times more harmful than saturated fats and has appealed to Health Canada to introduce regulations to severely limit the trans
fat content of foods.44,45
Cholesterol is primarily produced by the liver, but dietary cholesterol found in animal foods may contribute to elevated blood
cholesterol levels. Foods that have high levels of dietary cholesterol include egg yolks and organ meats, but all animal products
contribute to the cholesterol level of the diet. Every ounce of beef, lamb, pork, poultry and fish contains approximately 25 mg of
dietary cholesterol and 1 cup of milk contains 4–33 mg, depending on the fat content. Restricting dietary cholesterol intake can
achieve a 1–3% reduction in LDL-C.46
Saturated fats are the strongest contributor to elevated LDL-C levels. They are found primarily in animal foods (beef, chicken,
pork, whole-fat dairy products, eggs and lard) and in some plant-based foods (coconut, palm and palm kernel oils and cocoa
butter). Restricting saturated fat intake can achieve a 5–10% reduction in LDL-C.46,47 A large, prospective cohort study found that
replacing 5% of energy intake from saturated fats with equivalent energy intake from polyunsaturated fats, monounsaturated fats
or carbohydrates from whole grains was associated with a 25%, 15%, and 9% lower risk of CHD, respectively. However,
carbohydrates from refined starches or added sugars (e.g., sugar sweetened beverages or foods) have been positively associated
with a risk of CHD and should not be used to replaced saturated fat.48,49
Unsaturated fats include monounsaturated and polyunsaturated fats.47
Monounsaturated fats (MUFAs) include omega-7 (palmitoleic) and omega-9 (oleic).

They have been shown to improve blood cholesterol levels and are found in avocados, nuts, and vegetable oils (canola,
olive, peanut, safflower, sesame and sunflower oil).
Polyunsaturated fats (PUFAs) include both omega-3 and omega-6 fatty acids.
Omega-3 fatty acids can lower triglycerides and help prevent clotting of blood. They are found in cold-water fish
(mackerel, herring, sardines, salmon and trout), canola and soybean oils, nuts (walnuts, pecans, pine nuts) and seeds
(flaxseed, sunflower seed).
Omega-6 fatty acids lower LDL-C. They are found in vegetable oils (soybean, safflower, sunflower, corn oil), non-
hydrogenated margarine, nuts (almonds, pecans, brazil nuts) and seeds (sunflower).
Health Canada requires food products to state fat content (saturated fats, unsaturated fats, cholesterol and trans fats) on the
labels. Some guidelines to permitted food claims include:50
Fat-free: <0.5 g fat per serving of stated size

Low-fat: ≤3 g fat per serving of stated size
Reduced fat: modified to contain at least 25% less fat than a similar reference food
Light in fat: modified to contain at least 25% less fat than a similar reference food.
Beware of potentially misleading labels, such as:
“cholesterol-free” as only animal products contain cholesterol

“partially hydrogenated fat” as trans fats are formed in the processing
“low-fat” as fat may be replaced with refined carbohydrates (sugars) and the resulting product may be higher in calories.
Diet for Diabetes

Diet control is the first step in the treatment of diabetes. Proper diet can help control blood sugar levels. In many cases of type 2
diabetes, proper diet, along with exercise, can control the disease without the need for oral medications.
An appropriate diet helps achieve and maintain optimal blood glucose and lipid levels through appropriate food choices. It is
recommended for individuals diagnosed with type 1 diabetes, type 2 diabetes, gestational diabetes, impaired fasting glucose and
impaired glucose tolerance.
Meal planning is crucial. A typical meal plan includes breakfast, lunch, dinner and a night time snack. Some people also need to plan
other between-meal snacks. Being consistent in a diet is the most important part of meal planning. It is advisable to eat the same
number of calories, the same amounts of food and the same types of food at the same times each day. Regular scheduling of meals
helps to avoid sharp ups and downs in blood sugar. Individuals using insulin therapy should adjust their insulin based on the
carbohydrate content of their meals. This involves carbohydrate counting where dietary fibre is subtracted from the total
carbohydrates.
Dietitians with expertise in diabetes management can help individualize nutrition recommendations and also provide information on
carbohydrate counting and timing of insulin.
The Canadian Diabetes Association's 2013 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada
makes the following nutrition therapy recommendations:51
1. People with diabetes should receive nutrition counselling by a registered dietitian to lower HbA1c levels and to reduce
hospitalization rates.
2. Nutrition education is effective when delivered in either a small group or a one-on-one setting. Group education should
incorporate adult education principles, such as hands-on activities, problem solving, role playing and group discussions.
3. Individuals with diabetes should be encouraged to follow Canada's Food Guide to meet their nutritional needs.
4. In overweight or obese people with diabetes, a nutritionally balanced, calorie-reduced diet should be followed to achieve and
maintain a lower, healthier body weight.
5. In adults with diabetes, the macronutrient distribution as a percentage of total energy can range from 45–60% carbohydrate,
15–20% protein and 20–35% fat to allow for individualization of nutrition therapy based on preferences and treatment goals.
6. Adults with diabetes should consume no more than 7% of total daily energy from saturated fats and should limit intake of trans
fats to a minimum.
7. Added sucrose or added fructose can be substituted for other carbohydrates as part of mixed meals up to a maximum of 10%
of total daily energy intake, provided adequate control of blood glucose and lipids is maintained.
8. People with type 2 diabetes should maintain regularity in timing and spacing of meals to optimize glycemic control.
9. Dietary advice may emphasize choosing carbohydrate food sources with a low glycemic index to help optimize glycemic
control.
10. Alternative dietary patterns may be used in people with type 2 diabetes to improve glycemic control:
a. Mediterranean-style dietary pattern
b. Vegan or vegetarian dietary pattern
c. Incorporation of dietary pulses (e.g. beans, peas, chick peas, lentils)
d. Dietary Approaches to Stop Hypertension (DASH) dietary pattern.
11. An intensive lifestyle intervention program combining dietary modification and increased physical activity may be used to
achieve weight loss and improvements in glycemic control and cardiovascular risk factors.
12. People with type 1 diabetes should be taught how to match insulin to carbohydrate quantity and quality or should maintain
consistency in carbohydrate quantity and quality.
13. People using insulin or insulin secretagogues should be informed of the risk of delayed hypoglycemia resulting from alcohol
consumed with or after the previous evening’s meal and should be advised on preventive actions such as carbohydrate intake
and/or insulin dosage adjustments and increased blood glucose monitoring.
Resource Tips
Canadian Diabetes Association. Available from: www.diabetes.ca.
Health Canada. Eating well with Canada's food guide. Available from: www.hc-sc.gc.ca/fn-an/food-guide-aliment/index-eng.php.
DASH Diet (hypertension)
National Institutes of Health. National Heart, Lung, and Blood Institute. Your guide to lowering your blood pressure with DASH.
Available from: www.nhlbi.nih.gov/files/docs/public/heart/new_dash.pdf.
Gluten Intolerance
Canadian Celiac Association. Available from: www.celiac.ca.
Gluten Intolerance Group. Available from: www.gluten.net.
Mediterranean Diet
Mayo Clinic. Mediterranean diet: a heart-healthy eating plan. Available from: www.mayoclinic.org/healthy-lifestyle/nutrition-and-
healthy-eating/in-depth/mediterranean-diet/art-20047801.
Portfolio Diet
Harvard Health Publications. Harvard Medical School. What foods are included in the portfolio diet? Available from:
www.health.harvard.edu/diet-and-weight-loss/what-foods-are-included-in-the-portfolio-diet.
Suggested Readings
Adopting healthful lifestyle habits to lower LDL cholesterol and reduce CHD risk; and diet Appendices A, B and C. In: National
Institutes of Health. National Heart Lung and Blood Institute. Third report of the National Cholesterol Education Program (NCEP) Expert
Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III): final report. Available from:
www.nhlbi.nih.gov/sites/www.nhlbi.nih.gov/files/Circulation-2002-ATP-III-Final-Report-PDF-3143.pdf.
Anderson TJ, Gregoire J, Hegele RA et al. 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and
treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol 2013;29:151-67.
Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Canadian Diabetes Association 2013 Clinical Practice
Guidelines for the Prevention and Management of Diabetes in Canada. Can J Diabetes 2013;37:S1-S212. Available from:
guidelines.diabetes.ca/fullguidelines.
Khanna D, Fitzgerald JD, Khanna PP et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1:
systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken)
2012;64:1431-46.
References
Sports Nutrition
Shirley Heschuk, BScPharm, MSc

This chapter discusses the macronutrient, micronutrient and hydration requirements of athletes, as well as
nutritional supplements used as ergogenic aids (performance enhancers).
Macronutrients
Nutrition and Athletic Performance, the 2016 joint position statement of the Academy of Nutrition and
Dietetics, Dietitians of Canada and the American College of Sports Medicine, provides guidelines for energy,
nutrient and fluid intakes for active adults and competitive athletes.1 The position statement expresses
macronutrient (carbohydrate and protein) recommendations based on body weight to allow amounts to be
scaled to the range in body sizes of athletes (Table 1).
1
Table 1: Macronutrient Goals for Athletes
Nutrient Recommended Daily Intake
Carbohydrate 3–10 g/kg body weight

Up to 12 g/kg body weight for extreme and prolonged activities
Protein 1.2–2 g/kg body weight
Fat Individualize based upon training level and body composition goals.
20–35% total energy intake from fat is common in athletes.
Canada's Food Guide2 recommends consuming 30–45 mL (2–3
tbsp) of unsaturated fat and limiting total energy to <10% saturated
fat.
For optimal performance, energy consumed must be sufficient to match energy expended. The energy
intake required depends on the basal metabolic rate (BMR), the energy expended in physical activity and the
thermic effect of food (energy required to digest, absorb, transport, metabolize and store food). Adequate
energy needs to be consumed during periods of high-intensity and/or long-duration training to maintain body
weight and health and to maximize training effects. Loss of muscle mass, menstrual dysfunction, increased
risk of fatigue, injury and illness and a prolonged recovery process may occur if energy intakes are low.
Competitive athletes need an adequate energy intake for athletic performance, to maintain or increase lean
body mass and to repair tissue. They must consume enough calories to meet this energy demand. Some
athletes require >5000 calories per day.3 In addition, timing of nutrient intake and nutritional support should
be individualized to the athlete and his/her particular sport. It is best to consult a sports dietitian listed with
the Coaching Association of Canada (CAC) for specific meal plans for athletes (see Resource Tips).
Carbohydrate
Carbohydrate-rich diets can help maximize muscle and liver glycogen stores before exercise and
promote faster recovery of stores after exercise. Complex carbohydrates (e.g., starch, dextrin) are
preferred because they are digested slowly compared with simple sugars and supply a sustained release
of energy. They also provide fibre, iron (if enriched) and many of the B vitamins necessary for energy
metabolism. A summary of guidelines for carbohydrate intake by athletes can be found in Table 2.
Table 2: Guidelines for Carbohydrate Intake by Athletes

Situation Carbohydrate Targets Comments on Type and
Timing of Carbohydrate
Intake
Daily needs for fuel and recovery
1. The following targets are intended to provide high carbohydrate availability (to meet the
carbohydrate needs of muscle and CNS) for different exercise loads for scenarios where it
is important to exercise with high quality and/or at high intensity. These general
recommendations should be fine-tuned with individual consideration of total energy needs,
specific training needs, and feedback from training performance.
2. On other occasions, when exercise quality or intensity is less important, it may be less
crucial to achieve these carbohydrate targets or to arrange carbohydrate intake over the
day to optimize availability for specific sessions. In these cases, carbohydrate intake may
be chosen to suit energy goals, food preferences or food availability.
3. In some scenarios, when the focus is on enhancing the training stimulus or adaptive
response, low carbohydrate availability may be deliberately achieved by reducing total
carbohydrate intake, or by manipulating carbohydrate intake related to training sessions
(e.g., training in a fasted state or undertaking a second session of exercise without
adequate opportunity for refuelling after the first session).
Light: Low intensity or skill- 3–5 g/kg body weight per Timing of intake of
based activities day carbohydrate over the day
may be manipulated to
promote high carbohydrate
Moderate: Moderate exercise 5–7 g/kg body weight per availability for a specific
program (e.g., 1 h/day) day session by consuming
carbohydrate before or during
the session, or during
recovery from a previous
High: Endurance program 6–10 g/kg body weight per session.
(e.g., 1–3 h/day moderate- to day
high-intensity exercise) Otherwise, as long as total
fuel needs are provided, the
pattern of intake may simply
be guided by convenience and
Very high: Extreme 8–12 g/kg body weight per individual choice.
commitment (e.g., >4–5 day
Athletes should choose
h/day moderate- to high-
nutrient-rich carbohydrate
intensity exercise)
sources to allow overall
nutrient needs to be met.
Acute fueling strategiesa
General fueling up: 7–12 g/kg body weight per Athletes may choose
Preparation for events 24 h as for daily fuel needs carbohydrate-rich sources
involving <90 min exercise that are low in fiber/residue
and easily consumed to
ensure that fuel targets are
Carbohydrate loading: 10–12 g/kg body weight per
met, and to meet goals for gut
Preparation for events 24 h ˣ 36–48 h
comfort or lighter “racing
involving >90 min of
weight”.
sustained/intermittent
exercise
Speedy refueling: <8 h 1–1.2 g/kg body weight per h There may be benefit in
recovery between 2 fuel- for first 4 h then resume daily consuming small, regular
demanding sessions fuel needs snacks.
Carbohydrate-rich foods and
drinks may help to ensure that
fuel targets are met.
Pre-event fueling: Before 1–4 g/kg body weight Timing, amount and type of
exercise >60 min duration consumed 1–4 h before carbohydrate foods and
exercise drinks should be chosen to
suit the practical needs of the
event and individual
preferences/experiences.
Choices high in
fat/protein/fiber may need to
be avoided to reduce risk of GI
issues during the event.
Low-glycemic-index choices
may provide a more sustained
source of fuel for situations
where carbohydrate cannot be
consumed during exercise.
During brief exercise: <45 min Not needed
During sustained high- Small amounts, including A range of drinks and sports
intensity exercise: 45–75 min mouth rinse products can provide easily
consumed carbohydrate.
The frequent contact of
carbohydrate with the mouth
and oral cavity can stimulate
parts of the brain and CNS to
enhance perceptions of well-
being and increase self-
chosen work outputs.
During endurance exercise, 30–60 g/h Carbohydrate intake provides

including “stop and start” a source of fuel for the
sports: 1–2.5 h muscles to supplement
endogenous stores.
Opportunities to consume
foods and drinks vary
according to the rules and
nature of each sport.
A range of everyday dietary
choices and specialized
sports products ranging in
form from liquid to solid may
be useful.
The athlete should practice to
find a refuelling plan that suits
his or her individual goals,
including hydration needs and
gut comfort.
During ultra-endurance Up to 90 g/h As per endurance exercise.

exercise: >2.5–3 h Higher intakes of
carbohydrate are associated
with better performance.
Products providing multiple
transportable carbohydrates
(glucose/fructose mixtures)
achieve high rates of
oxidation of carbohydrate
consumed during exercise.
a These guidelines promote high carbohydrate availability to promote optimal performance during competition or
key training sessions.
Adapted from Burke LM, Hawley JA, Wong SH et al. Carbohydrates for training and competition. J Sports Sci 2011;29:S17–27. With
permission of Taylor & Francis Ltd, www.tandfonline.com.
Carbohydrate loading is recommended for athletes who compete in events that last 90 minutes or longer,
such as marathons, triathlons and cross-country skiing. The athlete consumes 60–70% of calories from
carbohydrate, while simultaneously decreasing the intensity and duration of exercise prior to
competition.3 The type of carbohydrate consumed is less important than the amount ingested.4 Athletes
who follow this regimen for up to a week before competition can significantly increase the glycogen
content of exercised muscles; this elevation can persist for 5 days with limited physical exercise and
taking in 60% of calories from carbohydrate.4,5 This strategy has been shown to enhance performance,
presumably by delaying fatigue.4 The type and duration of dietary manipulation and the exercise/training
activities varies and is flexible enough to personalize the athlete's pre-event preparation.4
Carbohydrate loading in women has not been well studied. Research has shown that up to 93% of total
energy as carbohydrate is required, and this could disrupt daily energy requirements.6 The menstrual
cycle may play a role as there is a greater capacity for storage of glycogen during the luteal phase than
during the follicular phase.7
The downside of carbohydrate loading is that for every 1 g of glycogen stored in muscle tissue, the body
also stores 2.7 g of water. This causes weight gain and a feeling of sluggishness.3
Fat
Fat is a necessary component of a healthy diet; it provides energy, helps maintain cell membranes and
aids absorption of fat-soluble vitamins. Fat intake should comprise 20–35% of total energy intake. Intake
of fat by athletes should be in accordance with public health guidelines and should be individualized
based on training level and body composition goals.1 Canada's Food Guide recommends consuming 30–
45 mL (2–3 tbsp) of unsaturated fat daily and limiting total daily energy to <10% saturated fat.2 Extreme
fat restriction limits food choices and sources of protein, fat-soluble vitamins (A, D, E and K), iron, zinc
and essential fatty acids. Reducing fat intake to less than 15% of total calories (e.g., weight restriction to
lose weight for an event) compromises fat stores and therefore endurance performance.8 Athletes
requiring a high caloric intake (>5000 calories per day) are recommended to consume ≤35% of calories
from fat.3,9 A high-fat diet is associated with impairment in exercise capacity10 and an increased risk of
cardiovascular disease.11 For more information on dietary fat, see Special Diets.
Protein
For adults >18 years of age, Canada's Food Guide recommends protein intake of 10–35% of total calories
or an intake of 0.8 g protein/kg body weight per day for the sedentary person. For athletes, Nutrition and
Athletic Performance recommends protein intake from 1.2–2 g/kg body weight per day to support
metabolic adaptation, repair, remodeling and protein turnover.1 Intensive training for short periods,
reduction of energy intake or sudden inactivity (e.g., as result of injury) may require even higher protein
intake.12,13
Athletes do not usually have difficulty consuming enough protein unless they are on a restricted diet.
Meeting this increased amount of protein does not require the use of protein or amino acid supplements.
The best way is to consume foods that contain high-quality protein, including low-fat dairy products, soy
products (e.g., tofu, tempeh), legumes, nuts, seeds, lean meats and fish. Intact, high-quality sources of
protein such as whey, casein or soy have been shown to be effective for maintenance, repair and
synthesis of skeletal muscle protein in response to training.14 When inconvenient to consume such
protein sources, more portable protein sources (bars, drinks, powders) offer a practical alternative. The
content should be closely scrutinized for quality. A dose of 20–25 g of high-quality protein appears to
maximally stimulate protein synthesis; above this point protein synthesis is not additionally stimulated,
but increases in amino acid oxidation and urea synthesis may result.15 Protein consumption as soon as
possible after exercise promotes recovery and possibly enhances the rate of adaptation of muscle to
improve function.12
Contrary to what many athletes believe, excess dietary protein does not have an anabolic effect and any
excess will be oxidized for energy production or stored as fat. In adult athletes, increased training rather
than excess protein intake builds muscle. There are few side effects from daily protein intakes under 2
g/kg in healthy people.
Some concerns regarding high protein intake include:
Diets high in protein are often high in fat

Excessive protein intake enhances diuresis, thus increasing the risk of dehydration as the body
attempts to excrete excess nitrogen
Acceleration of the progression of pre-existing renal disease16
Increased urinary calcium excretion, resulting in adverse effects on bone (osteoporosis).17
Amino Acids
High intake of single amino acids may impair absorption of other amino acids. The safety and quality
of amino acid supplements are questionable. They are expensive and their efficacy has not been
established.18,19,20 Amino acids are commonly taken by athletes as growth hormone-releasing
agents.21 Arginine, lysine and ornithine used in high doses may cause transient increases in human
growth hormone levels, but their effect is not sustained enough to increase muscle mass or decrease
body fat.22 Large doses may cause diarrhea and nausea while inhibiting the absorption of other
amino acids. Supplementation with protein or amino acids has not been shown to positively impact
athletic performance.23,24,25,26
Micronutrients
Ailments—Vitamin and Mineral Products: Liquid Combinations, Single Entity, Solid Combinations.
Restriction of energy intake, severe weight-loss practices, elimination of one or more food groups from the
diet or consumption of high- or low-carbohydrate diets of low micronutrient density can increase the risk of
micronutrient deficiencies. Athletes should consume the Recommended Dietary Allowance (RDA)27 of all
micronutrients.
B vitamins are essential for energy metabolism and are adequately supplied if sufficient calories and plenty
of complex carbohydrates, fruits and vegetables are part of an athlete's diet. Those following a gluten-free
diet may have difficulty meeting their vitamin B requirements as many gluten-free products are not fortified.
Vegans and some vegetarians require a vitamin B12 supplement.
Calcium helps to protect against stress fractures and, coupled with exercise, delays the onset of
osteoporosis (for more information, see Osteoporosis). The RDA of elemental calcium is 1300 mg for
children and adolescents 9–18 y, 1000 mg for adults 19–50 y, 1000 mg for men 51–70 y, 1200 mg for
women 51–70 y and 1200 mg for all adults >70 y. The RDA should ideally be met from food sources rather
than supplements. Some good dietary sources of calcium include dairy products, fortified dairy alternatives
(nut, rice or soy-based products), fortified orange juice, tofu, dried figs, cooked beans, collards and broccoli.
Vitamin D is required for adequate calcium absorption and regulation of serum calcium and phosphorus
levels. It also regulates the development and homeostasis of the nervous system and skeletal muscle. While
the current RDA for persons 1–70 years of age is 600 IU/day, growing evidence shows that this level might
be too low.28,29 Those who live in northern climates or train primarily indoors year-round are at risk of
vitamin D deficiency, especially if they do not consume foods fortified with vitamin D.
The female athlete triad includes the three interrelated conditions of amenorrhea, disordered eating and low
bone mineral density. For more information, see Resource Tips. Female athletes with inadequate diets
and/or amenorrhea or menstrual disturbances are at higher risk of early osteoporosis, and may have higher
calcium and vitamin D requirements.30
The International Olympic Committee (IOC) recommends 1500 mg/day of calcium and 1500–2000 IU/day of
vitamin D to optimize bone health in athletes with low energy intake or menstrual dysfunction.31
Magnesium plays a role in regulating metabolism, including energy utilization and work performance.
Engaging in intensive exercise may decrease tissue magnesium levels, partly due to magnesium losses in
perspiration. Persons with a low magnesium status exhibit reduced physiological strain during exercise
when their magnesium intake is increased.32 According to several studies, magnesium supplementation
produces benefits such as improved aerobic performance, greater strength and fewer exercise-induced
muscle injuries.33,34 In another clinical trial, magnesium supplementation did not improve exercise
performance.35 Supplementation or increased dietary intake of magnesium has a beneficial effect on
exercise performance in magnesium-deficient individuals but has questionable effects in individuals with
adequate magnesium status.36 Counsel athletes on good food sources of magnesium (e.g., halibut,
cashews, artichoke, peanut butter, pinto beans, banana, potato, broccoli).
Iron is needed to carry oxygen to active muscle cells. Female athletes are at higher risk of iron deficiency
(depletion) as a result of menstrual losses. Iron depletion is more common in endurance athletes, regular
blood donors and in those who consume a vegetarian or vegan diet (see Micronutrient Requirements of the
Vegetarian/Vegan Athlete). Lack of iron leads to fatigue; however, mild iron deficiency has little effect on
performance.37 Any concern about iron deficiency should be discussed with a healthcare practitioner.
Strenuous exercise can lower the body's reserve of other trace minerals such as copper (essential for red
blood cell synthesis) and zinc (important in many enzymes related to energy production). This may cause
marginal deficiencies, but does not necessarily require supplementation. High-dose supplements of iron,
copper or zinc can interfere with the normal absorption of these and other minerals, such that an excess of
one can cause a deficiency in another.9
Antioxidants: Vitamin C, vitamin E, beta-carotene and selenium help protect the body's cells from free-
radical damage. Exercise produces free radicals which are capable of damaging muscle fibres; however, the
body synthesizes a variety of endogenous antioxidants to counteract this effect. Also, physical training may
enhance the antioxidant defense system to offset the reactive oxygen species generated during exercise.38
Exogenous antioxidants (i.e., dietary antioxidants) interact with endogenous antioxidants to protect against
radical-mediated cellular damage. Antioxidant supplementation in sports is controversial. Vitamin C and
vitamin E supplementation was shown to hamper cellular adaptations in exercised muscles and therefore
caution is advised when considering supplementation.39 A review of the impact of antioxidant
supplementation on performance found that acute dietary intake of antioxidants is likely to be beneficial on
sport performance but chronic intake has a harmful effect.40 Until research confirms that the use of
antioxidant supplementation is safe and effective, the recommendation for physically active individuals is to
ingest a diet rich in antioxidants. Nutrient-rich foods include: fruits, vegetables, nuts, whole grains and
legumes.
A sports dietitian listed with the CAC can suggest a training diet to meet an athlete's needs for vitamins and
minerals through food, which is preferable to taking supplements; if the diet is nutritionally complete, using
supplements has not been shown to enhance performance.41
Micronutrient Requirements of the Vegetarian/Vegan Athlete
Vegetarian or vegan athletes may, with a well-planned diet, meet all of their micronutrient (vitamin and
mineral) needs. Nutrients that may be of concern are presented in Table 3.3,9,42
Table 3: Micronutrient Needs of the Vegetarian/Vegan Athlete

Micronutrient Comment Plant Sources
Calcium May need fortified foods and Calcium-fortified beverages (soy milk,
supplements to meet calcium orange juice), firm tofu, cooked beans,
needs. greens (kale, broccoli, bok choy), almonds,
figs, oranges.
Iron Vegetarians should consume Legumes, enriched cereals/breads, dark

1.8 times the iron of non- green leafy vegetables, nuts, dried fruit,
vegetarians since the blackstrap molasses, tofu.
nonheme iron in plant sources Spinach and beets have a high iron content
has lower bioavailability than but they contain phytates, which bind the
heme iron from animal iron and prevent absorption.
sources.
Absorption of iron from plant foods can be
increased if eaten together with a vitamin C
source, e.g., citrus fruits, tomatoes,
strawberries, red peppers (see Special
Diets).
Cooking, sprouting and fermenting
vegetables will release iron from phytates.
Riboflavin Important for the release of Bean sprouts, green peas, seaweed,
energy from food. nutritional yeast, almonds, mushrooms,
cooked soybeans, fortified soy beverages.
Vitamin B12 Found only in animal products Fortified soy beverages, fortified breakfast
or fortified plant products. cereal, nutritional yeast; if fortified foods are
not eaten, 5–10 µg daily as a supplement.
Vitamin D Levels may be low if vitamin Vitamin D–fortified soy beverages, fortified
D–fortified foods are not rice beverages, fortified margarine.
consumed (in addition to
other risk factors for
deficiency).
Zinc Better absorbed from animal Whole grains, seeds: soaking, sprouting and
sources than plant sources. grinding removes the phytates and improves
absorption.
Hydration
Exercise generates body heat, which is lost through evaporation of fluid (sweat) from the skin. Some elite
athletes lose as much as 1–2 L of fluid per hour and dehydration can occur quickly without fluid
replacement.3,9
Common signs of dehydration include:
thirst
dizziness
tiredness
nausea
chills
headache
muscle cramps.
Adequate fluid intake before, during and after exercise is necessary to prevent dehydration, which can
decrease exercise performance and increase risk of potentially life-threatening heat injury such as heat
stroke. Athletes are encouraged to consume a fluid volume of 5–10 mL/kg body weight in the 2–4 hours
before exercise (until urine is pale yellow in colour), sufficient fluid to replace sweat losses during exercise
and sufficient fluid to restore any deficit after exercise. Hydration strategies must be customized as sweat
rates vary during exercise from 0.3–2.4 L/h depending on exercise duration and intensity, climate, altitude
and the athlete's level of fitness. Acute changes in body weight reflect change in body water and allow
athletes to track their hydration status. Pre- and post-exercise body weight measurements aid in estimation
of fluid loss; a loss of 1 kg body weight correlates to 1 L sweat loss. While the sensation of thirst is a good
indication of the need for fluid, it is not a sign of dehydration. Older athletes should be advised there is an
age-related decrease in thirst sensation.1
Water can replace fluid lost in sweat but may not be adequate for rehydration because it does not contain
energy or electrolytes. Sodium helps to retain ingested fluids and should be included in fluid replacement
during and after exercise when large sweat losses occur.1
Sports drinks provide energy (from glucose, glucose polymers, sucrose) and electrolytes. Beverages
containing 6–8% glucose or sucrose are absorbed as rapidly as water and provide energy needed for
prolonged exercise.43 Electrolytes replace lost sodium, chloride and potassium, and enhance the palatability
of the beverage. Sodium and chloride help ensure an adequate intake of fluid and stimulate greater
rehydration or thirst after exercise.
Dietitians of Canada suggests that sports drinks contain:44

Carbohydrates: 30–60 g/L from different sources such as glucose, sucrose, fructose and/or
maltodextrin
Sodium: 460–690 mg/L (or at least 70 mg/250 mL)
Potassium: 78–195 mg/L
Fruit juices and soft drinks are concentrated sources of carbohydrate (>10% carbohydrate concentration),
which may deter fluid replacement and cause GI discomfort.43 A homemade sports drink can be made by
diluting unsweetened fruit juice with water and adding iodized table salt, e.g., 500 mL unsweetened orange
juice, 500 mL water and 1–2 mL (one-quarter to one-half teaspoonful) iodized table salt (one-quarter
teaspoonful table salt = 500 mg Na+);45 the resulting 1 L mixture contains 54 g (5.4%) carbohydrate.
Most people exercising for <1 hour should drink water only. Sports drinks may be appropriate when
participating for <1 hour in intense sports, when doing endurance sports (>1 hour) or when exercising in hot
weather.3,9,43,45,46
Hyperhydration
Excessive drinking of water during exercise can cause hyponatremia (blood sodium <135 mmol/L).
Signs of hyponatremia include:
weight/fluid gain
mental confusion
general weakness.
Hyponatremia can lead to seizures, coma and even death. Recreational athletes have been identified as
being at risk of over-hydration and hyponatremia as their work output and sweat rates are lower, and their
belief in the need to drink and opportunities to drink are often greater, compared with competitive athletes.1
To prevent over-hydrating during an event, recreational athletes are encouraged to drink only enough water
to quench thirst.
Nutritional Supplements as Ergogenic Aids

Most sports nutritional supplements are marketed as ergogenic aids and lack rigorous clinical trials to
evaluate efficacy. They are unnecessary when athletes select the right variety of foods to meet their energy
needs.
The safety of some of these products may be questionable, largely due to possible contamination with
extraneous substances. These substances may be dangerous, prohibited during sports competitions or
illegal, e.g., androstenedione, dehydroepiandrosterone (DHEA) and other anabolic androgenic steroids,
Tribulus terrestris, ephedra, strychnine or human growth hormone. Ingestion of prohibited substances may
jeopardize the athlete's eligibility to compete (see Drug Use and Abuse in Sports).
Vitamins, minerals and amino acids have been added to many food products and have been regulated as
Natural Health Products (NHPs). Health Canada is in the process of moving these products to the food
regulatory framework to resolve confusion while maintaining safety. Examples of these products include
energy drinks, waters and juices with added vitamins and minerals, and yogurts and bars with specific health
claims. Maximum allowable levels of vitamins, minerals and amino acids are defined.
Since December 2013, caffeinated drinks that contain 200–400 ppm (mg/L) of caffeine from all sources and
are prepackaged, ready-to-consume and predominately water-based have been classified as food products
(formerly NHPs). “Energy shots” containing ≤90 mL liquid and intended as a single dose are classified as
NHPs. A list of permitted and prohibited ingredients and monographs for NHPs can be found on Health
Canada's website (see Resource Tips).
Liquid supplements and sports bars that contain carbohydrate, protein and fat provide an easy way to
increase energy intake. Athletes should read labels in order to incorporate these into their daily diet. Sports
drinks can contribute needed fluids and carbohydrates before, during and after exercise. Some of these
products may contain other components promoted as ergogenic (e.g., chromium, amino acids, ginseng)
which make them more expensive.
Supplements with Evidence to Support Claims
Table 4 summarizes sports food and supplements that have evidence to support the claimed benefits.
For more information on sports supplements, see Drug Use and Abuse in Sports.
Table 4: Supplements with Evidence-based Uses in Sports Nutrition

Category Examples Uses Concerns
Sports food47 sports drinks Practical choice More expensive than

sports bars to meet sports whole foods
nutrition goals May be used
sports confectionery especially when unnecessarily or in
sports gels access to food, inappropriate
opportunities to protocols
electrolyte supplements
consume
protein supplements nutrients, or GI
liquid meal supplements concerns make
it difficult to
consume
traditional food
and beverages
Medical iron supplements Prevention or May be self-

supplements47 calcium supplements treatment of prescribed
vitamin D supplements nutrient unnecessarily without
multivitamin/mineral deficiency under appropriate
the supervision supervision or
omega-3 fatty acids of appropriate monitoring
medical/
nutrition expert
Specific Performance Ergogenic Effects Physiological Concerns Regarding

Supplements Effects/ Usea
Mechanism of
Ergogenic Effect
Creatine48 Improves performance of Increases Associated with

repeated bouts of high- creatine and acute weight gain
intensity exercise with phosphocreatine (0.6–1 kg), which
short recovery periods concentrations may be problematic
Direct effect on May also have in weight-sensitive
competition other effects sports
performance such as May cause GI
Enhanced capacity enhancement of discomfort
for training glycogen Some products may
storage and not contain
direct effect on appropriate amounts
muscle protein or forms of creatine
synthesis
Caffeine48,49,50 Reduces perception of Adenosine Causes side effects

fatigue antagonist with (e.g., tremor, anxiety,
Allows exercise to be effects on many increased heart rate)
sustained at optimal body targets, when consumed in
intensity/output for including CNS high doses
longer Promotes Ca2+ Toxic when
release from consumed in very
sarcoplasmic large doses
reticulum Rules of National
Collegiate Athletic
Association
competition prohibit
the intake of large
doses that produce
urinary caffeine levels
exceeding 15 µg/mL
Some products do
not disclose caffeine
dose or may contain
other stimulants
Sodium bicarbonate51 Improves performance of When taken as May cause GI side

events that would an acute dose effects that cause
otherwise be limited by pre-exercise, performance
acid-base disturbances increases impairment rather
associated with high extracellular than benefit
rates of anaerobic buffering
glycolysis capacity
High-intensity
events of 1–7 min
Repeated high-
intensity sprints
Capacity for high-
intensity “sprint”
during endurance
exercise
Beta-alanine52 Improves performance of When taken in a Some products with

events that would chronic protocol, rapid absorption may
otherwise be limited by achieves cause paresthesia
acid-base disturbances increase in (i.e., tingling
associated with high muscle sensation)
rates of anaerobic carnosine
glycolysis (intracellular
Mostly targeted at buffer)
high-intensity
exercise lasting 60–
240 s
May enhance
training capacity
Nitrate53 Improves exercise Increases Consumption in

tolerance and economy plasma nitrite concentrated food
Improves performance in concentrations sources (eg, beetroot
endurance exercise at to increase juice) may cause gut
least in nonelite athletes production of discomfort and
nitric oxide with discoloration of urine
various vascular Efficacy seems less
and metabolic clear cut in high-
effects that caliber athletes
reduces O2 cost
of exercise
a Athletes should be assisted to undertake a cost-to-benefit analysis47 before using any sports food and
supplements with consideration of potential nutritional, physiological, and psychological benefits for their specific
event weighed against potential disadvantages. Specific protocols of use should be tailored to the individual
scenario (see references for further information) and specific products should be chosen with consideration of
the risk of contamination with unsafe or illegal chemicals.
Adapted with permission from Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of
Sports Medicine: Nutrition and athletic performance. Can J Diet Pract Res 2016;77:54. Available from Dietitians of Canada at
www.dietitians.ca/sports.
Resource Tips
Coaching Association of Canada. Find a dietitian. Available from: www.coach.ca/find-a-dietitian-p140496.
Coaching Association of Canada. Sport nutrition. Available from: www.coach.ca/sport-nutrition-tips-s13426.
Dietitians of Canada. Nutrition A-Z (alphabetical listing of materials). Available from: www.dietitians.ca/Your-
Health/Nutrition-A-Z.aspx.
Female Athlete Triad Coalition. An International Consortium. Available from: www.femaleathletetriad.org/.
Health Canada. Natural and non-prescription health products. Available from: www.hc-sc.gc.ca/dhp-
mps/prodnatur/index-eng.php.
43. Marriage B, Schnurr H, Carter-Erdman KA et al. Sports nutrition: resource manual. 2nd ed. Edmonton:
Sport Medicine Council of Alberta; 1999.
44. Dietitians of Canada. Sports nutrition (adult). Sports hydration. Available from:
www.dietitians.ca/Your-Health/Nutrition-A-Z/Sports-Nutrition-%28Adult%29/Sports-Hydration.aspx.
Accessed April 26, 2016.
45. Coaching Association of Canada. Sport Nutrition Advisory Committee. Fluids and foods during
training/competition. Available from: coach.ca/fluids-and-foods-during-training-competition-
p154683. Accessed April 26, 2016.
46. von Duvillard SP, Arciero PJ, Tietjen-Smith T et al. Sports drinks, exercise training, and competition.
Curr Sports Med Rep 2008;7:202-8.
47. Burke LM, Cato L. Supplements and sports foods. In: Burke LM, Deakin V, eds. Clinical sports
nutrition. 5th ed. North Ryde: McGraw- Hill; 2015. p. 493-591.
48. Tarnopolsky MA. Caffeine and creatine use in sport. Ann Nutr Metab 2010;57:1-8.
49. Astorino TA, Roberson DW. Efficacy of acute caffeine ingestion for short-term high-intensity exercise
performance: a systematic review. J Strength Cond Res 2010;24:257-65.
50. Burke L, Desbrow B, Spriet L. Caffeine for sports performance. Champagne: Human Kinetics; 2013.
51. Carr AJ, Hopkins WG, Gore CJ. Effects of acute alkalosis and acidosis on performance: a meta-
analysis. Sports Med 2011;41:801-14.
52. Quesnele JJ, Laframboise MA, Wong JJ et al. The effects of beta-alanine supplementation on
performance: a systematic review of the literature. Int J Sport Nutr Exerc Metab 2014;24:14-27.
53. Jones AM. Influence of dietary nitrate on the physiological determinants of exercise performance: a
critical review. Appl Physiol Nutr Metab 2014;39:1019-28.

Nutrition for Athletes
Nutrition for Athletes—What You Need to Know
Athletes can improve their health and athletic performance by eating well. A good diet is important whether you play
recreational or competitive sports. Here’s what you need to know about eating well for sports.
A high-carbohydrate diet enables your body to store energy.

Recreational athletes should get 45–65% of their energy from carbohydrates.
Endurance (competitive) athletes should get 60–70% of their energy from carbohydrates.
To increase your carbohydrate intake, eat more whole-grain products, vegetables and fruit.
You should keep your fat intake low and avoid saturated fats. Aim to get 20–35% of your energy from fats, but
less than 10% from saturated fats. To reduce saturated fat:
Reduce your intake of animal products.
Choose lower-fat dairy products (skim milk, 1% milk, cheese with less than 20% milk fat, yogourt with less
than 2% milk fat).
Choose lean cuts of meat (lean ground beef, sirloin and flank steaks).
Bake or broil foods, rather than frying.
Your body needs protein to keep your muscles strong and to produce antibodies to fight infection. However,
you do not need a large amount of protein. The amount varies with your body size and your level of activity.
People who are not active or only occasionally participate in physical activity (e.g., recreational sports) should
consume 0.8 g of protein for every kilogram of body weight per day. Athletes who train regularly require 1.2–2 g
of protein for every kilogram of body weight per day, depending upon the intensity of their training. Daily protein
requirements can easily be met if protein makes up 10–35% of the diet.
You do not need vitamin and mineral supplements if you eat the right variety of foods every day.
It is important to be well hydrated during sports. Follow these guidelines to get the right amount of fluid:
During exercise, drink enough to replace water lost through sweat.
Drinking after the activity to satisfy thirst is also important to replace lost fluids.
For exercise lasting less than 1 hour, water is best.
For exercise lasting >1 hour, for intense exercise lasting <1 hour or if exercising in hot weather, use diluted
glucose and electrolyte solutions (sports drinks with 6–8% carbohydrate).
Weight Management
Shirley Heschuk, BSc Pharm, MSc

Overweight/Obesity
Introduction
Overweight/obesity is a chronic condition characterized by an accumulation of body fat in adipose tissue
resulting from excessive caloric intake and inadequate caloric loss. Various methods are used for objective
measurement of overweight/obesity. The body mass index (BMI) is the most commonly used clinical
measurement and is calculated by dividing the person's weight in kilograms by the person's height in metres
squared (kg/m2). See Resource Tips for suggested sources of BMI calculators.
The internationally recognized cut-off BMI values for adults are shown in Table 1.1,2
Table 1: Definition of Adult Overweight and Obesity
Normal
Parameter Underweight Weight Overweight Obesity
Moderate Severe
Mild or or or
Class I Class II Class III
BMI (kg/m2) <18.5 18.5–24.9 25–29.9 30–34.9 35–39.9 ≥40
The lower end of the BMI ranges is for the small-framed person with less muscle and the higher end of the
range is for a large-framed person or one who carries more muscle. BMI measurements are useful for ages
20–65.3 The definitions do not apply to infants, children, adolescents, pregnant or breastfeeding women, or
adults over 65 years of age.4
For infants, children and adolescents ages 2–19 years, Canadian dietitians adapted World Health
Organization (WHO) growth charts to assess obesity.5 The weight-for-length or BMI-for-age percentile
determines the cut-offs for obesity (see Table 2). More cautious cut-offs are recommended for younger
children (birth to 2 years) to avoid the risk of putting young children on diets.
Table 2: Definition of Pediatric Overweight and Obesity

Category (cut-off percentile)
Age Group Risk of Overweight Obesity Severe Obesity

Overweight
Birth to 2 ya >85th >97th >99.9th Not applicable
2–5 yb, >85th >97th >99.9th Not available
5–19 yb Not available >85th >97th >99.9th
a Weight-for-length
b BMI-for-age
In the elderly (>65 years), the ideal BMI may be in a higher range, as research has shown that overweight and
obese BMI does not appear to confer increased risk of mortality,6 and underweight BMI can pose a greater
threat than being overweight or obese.7,8 More research is needed to determine optimal BMI in the elderly.
Physically active people who regularly perform muscle-resistance exercise may have an overweight or obese
BMI even though they have normal or even low body fat content. BMI measurement does not provide
information about the distribution of body fat. Central body fat distribution, or abdominal fatness, can be
determined indirectly by measuring waist circumference.
To measure waist circumference:9
Patient should be in the standing position

Place measuring tape horizontally around waist at the level of the iliac crest (top of the hip bones)
Measurement is made at the end of a normal expiration.
Cut-off values have been proposed for healthy waist circumference. Measurements higher than these show
an increased prevalence of comorbidities. These values can vary with gender, age and ethnicity (Table 3).
Waist circumference has been incorporated with the measurement of BMI to determine obesity-related
health risk and morbidity (Table 4).
10
Table 3: Ethnicity-specific Values for Waist Circumference as a Measure of Central Obesity
Country or Ethnic Group Waist Circumference (cm)
Men Women
North American (NCEP-ATP III) >102 >88
Caucasian ≥94 ≥80
South Asian, Chinese, Japanese ≥90 ≥80
South and Central American Use South Asian values until more specific data are
available
Sub-Saharan African Use Caucasian values until more specific data are
available
Eastern Mediterranean and Middle East Use Caucasian values until more specific data are
(Arab) available
Abbreviations: NCEP-ATP III = National Cholesterol Education Program—Adult Treatment Panel III
Adapted with the permission from International Diabetes Federation. The IDF consensus worldwide definition of the metabolic
syndrome. Available from: www.idf.org/webdata/docs/MetS_def_update2006.pdf.
Table 4: Classification of Overweight and Obesity by Body Mass Index (BMI), Waist Circumference and
1
Associated Disease Risk
Weight BMI Obesity Class Disease Riska
Category (kg/m2)
Weight BMI Obesity Class Waist Disease Waist
Riska
Category (kg/m2) Circumference: Circumference:
Men ≤40 in (≤102 Men >40 in (>102
cm) cm)
Women ≤35 in (≤88 Women >35 in (>88
cm) cm)
Underweight <18.5
Normalb 18.5–24.9 Waist

Least Waist
Increased
Circumference: Circumference:
Men ≤40 in (≤102 Men >40 in (>102
Overweight 25–29.9 Increased
cm) High
cm)
Women ≤35 in (≤88 Women >35 in (>88
Obesity 30–34.9 I cm)
High cm)
Very high
35–39.9 II Very high Very high
Extreme ≥40 III Extremely high Extremely high

obesity
a Disease risk of increased waist circumference (increased abdominal fat) added to disease risk of BMI for type 2
diabetes, hypertension and cardiovascular disease. Indicates relative risk; relative to risk at normal weight and waist
circumference.
b Increased waist circumference can also be a marker for increased risk, even in persons of normal weight.
Adapted with permission from National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight
and obesity in adults—the evidence report. Obes Res 1998;6(Suppl 2):51-209S.
Prevalence
The rates of overweight and obesity in Canada classified by age group and gender are presented in Table
5.11,12
Table 5: Rates of Overweight and Obesity in Canada by Age and Gender

Weight Age 5–11 y Age 12–17 y Age 18–79 y
Category
Females Males Females Males Females Males
Overweight 19% 14% 18% 23% 28% 43%
Obese 9% 8% 12% 21% 26% 27%
The prevalence of overweight and obesity has increased in Canada over the last several years in both
adults and children. Obesity rates have tripled, from 6.1% to 18.3%, between 1985 and 2011, with a
disproportionate increase within obesity classes II and III (correlating with a BMI ≥35). If the current trend
continues, it is predicted that 21% of the Canadian adult population will be obese by 2019.13
Data from the Canadian health surveys administered between 2001 and 2011 show significant provincial
variations in the prevalence and rate of change of adult obesity levels over time. Compared with the
national average of 18.3% obese adults in 2011, rates were lower in Quebec and British Columbia, similar
in Ontario and Alberta, and higher in the remaining 6 provinces. The Atlantic provinces reported the
highest levels of obesity in the country and Newfoundland and Labrador showed a much higher rate of
increase (73.3%) compared with other provinces. It is predicted that half of Canadian provinces will have
more overweight or obese adults than normal weight adults by 2019.13
The prevalence of obesity, in both men and women, increases with age. Prevalence is also affected by
socioeconomic status, education level and ethnic or cultural differences. Poverty and lower educational
attainment are associated with higher than average rates of obesity.14 In Canada, those at highest risk of
overweight and obesity are Canada’s aboriginal peoples, followed by individuals of Latin American and
African ancestry.15
Level of physical activity is inversely related to development of obesity. Obesity is more prevalent in
persons with sedentary lifestyles or a disability that restricts activity.16
Health Risks of Obesity

Cardiovascular:
Obesity is a major modifiable cardiovascular disease risk factor.17 It is associated with an
increase in hypertension, heart failure, dyslipidemia, atrial fibrillation, stroke, arrhythmias and
venous disease.18 Obesity is associated with premature acute MI19 and causes a 3.3-fold
increase in cardiovascular disease in American women with a BMI >29 compared with a BMI
<211,20
Incidence of hypertension is 3 times higher in obese patients. In the Framingham study,
hypertension developed 10 times more often in persons who were overweight by 20% or more
than in those of normal weight21
A 14-year follow up of Framingham Heart Study participants showed that every 1 kg/m2
increase in BMI increased the risk of heart failure 5% in men and 7% in women18
Obesity is associated with low high-density lipoprotein cholesterol (HDL-C), high triglycerides
and high low-density lipoprotein cholesterol (LDL-C). In the Framingham study, every 10%
increase in relative weight was associated with an increase in plasma cholesterol of 0.3
mmol/L21,22
Varicose veins, venous stasis and pulmonary embolism are more common in obese patients.
Cancer: A population-based cohort study of 5.24 million United Kingdom adults found that BMI was
associated with 17 of 22 cancers investigated.23 A linear association was found with leukemia and
cancers of the uterus, gallbladder, kidney, cervix and thyroid for each 5 kg/m2 increase in BMI. A
positive association was also observed in several cancer types (e.g., liver, colon, ovarian and
postmenopausal breast cancers). Similarly, a systematic review and meta-analysis assessed the
association between BMI and incidence of cancer by cancer site, gender and ethnic group.24 A 5
kg/m2 increase in BMI in men was strongly associated with esophageal adenocarcinoma, thyroid,
colon and renal cancers. In women, a strong association between increased BMI and endometrial,
gallbladder, esophageal adenocarcinoma and renal cancers was observed. Associations were
similar in North American, European, Australian and Asia-Pacific populations, but there was
stronger association in Asia-Pacific populations between increased BMI and pre- and
postmenopausal breast cancers.24
Endocrine and metabolic:
Mildly obese persons have a twofold risk, moderately obese a fivefold risk, and severely obese
a tenfold risk of developing type 2 diabetes.25 Seventy-five percent of Canadians with type 2
diabetes are overweight or obese26
The enlarged fat cell is less sensitive to the antilipolytic and lipogenic actions of insulin
Obese patients have a slightly higher risk of hypothalamic, pituitary, thyroid, adrenal, ovarian
and pancreatic syndromes as well as irregular menses, reduction of fertility and toxemia.
Gastrointestinal:
Gallstones occur 3–4 times more often in obese than nonobese persons
Gastroesophageal reflux disease (GERD): Overweight and obese patients have a high
prevalence of GERD symptoms (37%). A prospective intervention trial showed that a structured
weight-loss program reduced and resolved GERD symptoms in 81% and 65% of subjects,
respectively.27
Gout: The Canadian Health Survey found that the percentage of men with uric acid levels >416
μmol/L increased from 7% to 31% as the BMI increased from 21 to 31. Women were not affected
until they reached a BMI >31, when the percentage prevalence was 7%.28 Among participants (age
≥20 years) of the US National Health and Nutrition Examination Surveys in 1988–1994 and 2007–
2010, a 1-unit higher BMI was associated with a 5% greater prevalence of gout.29
Infection: Obesity increases the risk of nosocomial infections,30 surgical site infections,
periodontitis and skin infections.31 Fungal and yeast infections are more common in the obese
population.
Liver: Obesity is a main risk factor for NAFLD (nonalcoholic fatty liver disease) and NASH (non-
alcoholic steatohepatitis). A prospective study confirmed NAFLD in 63% and NASH in 26% of obese
patients undergoing gastric bypass.32
Mortality: Incidence of mortality in subjects with a BMI >26 is 1.67 times higher than those with a
BMI <22.5.1,33 However, in adults ≥65 y of age the risk of mortality increased with a BMI <23 and
being overweight was not found to be associated with an increase in mortality.8
Osteoarthritis: Obesity is associated with increased risk of both development and progression of
osteoarthritis of the knee.34,35
Pregnancy: Obesity may complicate pregnancy and negatively affect pregnancy outcomes. Obese
women have an increased risk of Cesarean delivery and post-Cesarean wound complications,
gestational diabetes, gestational hypertension, preeclampsia, preterm delivery and postpartum
anemia.36,37,38 Additionally, neonates born to obese mothers are at higher risk of negative
outcomes (e.g., bacterial sepsis, hypoglycemia or respiratory distress syndrome).39,40 Studies
looking at neonates through childhood and into adult life have also found that maternal pre-
pregnancy obesity has a negative impact on several outcomes (e.g., hypertension, childhood
obesity and infertility).39
Psychological: Poor self-image and impaired social relationships, depression and anxiety are all
worsened by obesity.
Respiratory: Obstruction by local accumulation of fat leads to hypoventilation and hypoxia, resulting
in sleep apnea. Obstructive sleep apnea (OSA) can lead to cardiac arrhythmias, nocturnal hypoxia,
heart failure and pulmonary hypertension.1 OSA is very common in bariatric surgery patients (71%)
with a higher prevalence in males (90%) than females (60%).41
Other: Stretch marks (striae) are more common in the obese population.
Economic Burden of Obesity

The combined annual economic burden of overweight and obesity in Canada was estimated at $19
billion in 2012, with $7.5 billion attributed to overweight and $11.5 billion to obesity. This comprises both
direct costs to the healthcare system (hospital care, pharmaceuticals, physician care and institutional
care) and indirect costs to productivity (the value of economic output lost as a result of premature death
and short- and long-term disability) and the total is expected to increase as the population grows. A 1%
relative reduction in the incidence of overweight and obesity could have substantial positive economic
impact over time.42
Pathophysiology
Obesity is a chronic disease developed from interactive influences of numerous factors: organic, hereditary
(genetic), physiologic, metabolic (set-point theory), medications, psychological and environmental.
An identifiable organic cause can only be found in a small percentage of people. Weight gain in excess of 1
kg per day invariably implies fluid retention and is frequently a sign of a cardiovascular, renal or hepatic
disorder. Other causes may be endocrinopathies such as insulinoma, Cushing's disease or thyroid
dysfunction.
Although obesity is associated with several genetic syndromes (e.g., Prader-Willi, Bardet-Biedl and Cohen),43
in the absence of a genetic syndrome the role of heredity is not easily assessed as environmental factors
pertaining to food intake greatly confound this issue. If both parents are of normal weight, the incidence of
having an obese child is approximately 9%. If one parent is obese, the rate increases to 50% and if both
parents are obese, the rate is 80%.44
Adipose tissue grows through an increase in both size and number of cells. Fat infants have a higher chance
of being obese in adulthood than do lean infants but obesity is not inevitable for those in the high percentiles
of weight for height, age and gender in the early years.45 Childhood obesity accounts for only a minority of
cases of obesity in adults.46,47
Many physiologic factors may affect obesity, such as neurotransmitters, neuropeptides and hormones. The
hypothalamus receives input from peripheral satiety sites, leptin (a hormone produced by fat cells to signal
satiety), ghrelin (a hormone produced from the stomach to increase appetite) and the indoleamine
neurotransmitter system in the brain, all of which are thought to play a role in obesity.
Sleep deprivation may be associated with overweight and obese status, as demonstrated in several
studies.48 Reduced sleep decreases the secretion of leptin and increases the secretion of ghrelin, resulting
in increased hunger and appetite.49 Individuals who are awake longer are more exposed to food stimuli,
leading to a greater propensity to overeat.50
Concerning metabolic influences, the set-point theory proposes that the body has an internal control
mechanism, a set-point, probably located in the hypothalamus, which drives the body to maintain a
particular level of body fat. Exercise can lower the particular setting, whereas dieting has no effect. Each
time we manage to reduce our fat level below our “natural” set-point, the body makes internal adjustments to
resist this change and conserve or replenish body fat, making it difficult to lose weight. There is little
evidence to support adaptive metabolic changes as an explanation for the tendency of weight-reduced
persons to regain weight.51
Weight gain is also a common side effect of certain medications (see Table 6).52,53,54
Psychiatric disorders may be associated with obesity.55 Depression and obesity may contribute to each
other in a cyclical manner; more study is warranted to determine the mechanism of this relationship.56
Integrating treatment for psychiatric disorders with weight loss measures may be beneficial.55
Environmental factors such as social and cultural background, an increase in sedentary behavior, and
economic forces (food prices, agricultural subsidies, wages, availability of low-cost, high-energy-dense
foods, portion sizes) have caused waist girth and weight to rise dramatically in modernized societies.57
Table 6: Medications Associated with Weight Gain

Class Drugs Mechanism Typical Possible
Weight Gain Alternatives
Antidepressants tricyclic Unclear; may Appears to be bupropion
antidepressants attenuate related to the fluoxetine
(e.g., amitriptyline) serotonin- particular
mediated signal drug and the sertraline
mirtazapine
transduction, dose and
can produce a duration of
reduction in therapy, e.g.,
BMR. amitriptyline
(1.8 kg),
mirtazapine
(1.5 kg).
Continued
weight gain
can be
predicted to
occur with
continued
treatment, but
at a slower
rate than the
initial 3
months of
therapy.
monoamine oxidase Unclear; Less

inhibitors increases profound than
hunger and with TCAs.
craving for
sweets.
Antiepileptic valproic acid Unclear; 15–20 kg Topiramate

drugs enhances GABA over variable lamotrigine
functions which lengths of
stimulate treatment.
carbohydrate
intake and
reduce BMR.
carbamazepine Water retention; Up to 15 kg

mechanism during a 3-
unclear. month
Possible treatment
antidiuretic course.
hormone
involvement.
Possible
norepinephrine
or serotonin
effect.
Antihyperglycemic insulin Elimination of Up to 8 kg acarbose
agents glycosuria during an metformin
results in intensive 3-
increase in fat month course DPP-4
mass. of therapy. inhibitors
GLP-1 receptor
agonists
SGLT2
inhibitors
meglitinides, Unclear Up to 5 kg
sulfonylureas, during 3–12
thiazolidinediones months of
treatment.
Antimanic agents lithium Produces 10 kg or more

polydipsia, in 6–10 y; up
causes sodium to 28 kg has
and water been
retention, reported.
inhibits
synthesis of
thyroid hormone,
blocks dopamine
receptors
inducing feeding,
increases GABA
functions (see
above).
Antineoplastic tamoxifen Unclear Average 2.5–

agents 6 kg, up to 10
kg or more.
Antipsychotic first-generation Blocks Clozapine: aripiprazole

agents antipsychotics dopamine D2 average 12 kg ziprasidone
and serotonin over 16 wk of
receptors to therapy.
cause increased
appetite.
second-generation Loxapine: 9
(atypical) kg in 36 wk.
antipsychotics
Corticosteroids e.g., Stimulates food Prednisone;

dexamethasone, intake, causes average of 2
prednisone hyperinsulinemia kg during a 6-
which promotes month daily
fat deposition. course of
therapy.
Hormones estrogen, Unclear; possible Variable For
progesterone, increased contraception:
testosterone or appetite or body barrier
other fat. methods or
anabolic/androgenic copper IUD
steroids
Migraine flunarizine Possible 4 kg at dose

prophylaxis increased of 10 mg per
agents appetite; day for 60
dopamine effect. days of
treatment.
pizotifen Unclear; possible 2–10.5 kg in

serotonin effect. 8 wk of
treatment.
Abbreviations: BMR = basal metabolic rate; GABA = gamma-aminobutyric acid; TCA = tricyclic antidepressant; IUD
= intrauterine device
Goals of Therapy
Refocus from weight change alone, which is aimed at appearance, to weight management, achieving
the best weight possible in the context of overall health
Reduce body weight or at least prevent further gain—for initial weight loss, a realistic goal of 10%
weight reduction should be set (approximately 1 kg weight loss per week over 6 months)
Abate the complications associated with obesity
Achieve and maintain a healthy weight range (BMI between 18.5 and 24.9) long term
Patient Assessment
The Canadian Task Force on Preventive Health Care strongly recommends primary care providers measure
weight and height to calculate BMI and measure waist circumference to assess obesity-related health risks
at all appropriate visits, to identify underweight, overweight and obese patients.2 If this is done on a regular
basis, early intervention can address any unwanted change in BMI and health risk factors.
The 5As intervention, which was developed for smoking cessation, has been modified by the College of
Family Physicians of Canada for use in obesity management. The 5As (ask, assess, advise, agree and
assist) comprises a manageable, evidence-based, behavioural intervention strategy that has the potential to
improve the success of weight management within primary care (see Table 7).58
Approaches to use in the treatment of obesity include nutrition therapy, physical activity, cognitive
behavioural therapy, pharmacotherapy and surgery.1 An assessment tool for stepwise management of the
overweight or obese adult is presented in Figure 1.
58
Table 7: The 5As of Obesity Management and Counselling
A Definition Rationale Counseling
Ask Ask permission to Weight is a sensitive Ask permission to

discuss weight; be issue; avoid verbal discuss weight:
nonjudgmental; cues that imply “May I talk to you
explore readiness for judgment; indication about your weight?”
change of readiness might
predict outcomes “Are you concerned
about the effects of
your weight on your
health or quality of
life?”
“Would it be alright if
we discussed your
weight?”
Be sure to affirm that
you hear what the
patient says
Explore readiness to
change:
“Are you ready to work
on your weight? Would
it be okay if I helped?”
“How important is it
for you to work on your
weight?”
“How confident are
you that you can take
action on your goal?”
Assess Assess BMI, WC, BMI alone should Assess health status,
obesity stage; explore never serve as an BMI, WC, waist-hip
drivers and indicator for obesity ratio, root causes of
complications of interventions; obesity weight gain, and
excess weight is a complex and effects of weight on
heterogeneous psychosocial
disorder with multiple functioning
causes; drivers and Use the Edmonton
complications of Obesity Staging
obesity will vary
among individuals System59,60
Advise Advise on health risks Health risks of excess Advise about the risks
of obesity, benefits of weight can vary; of obesity; explain the
modest weight loss, avoidance of weight benefits of modest
the need for a long- gain or modest weight weight loss and the
term strategy, and loss can have health need for long-term
treatment options benefits; strategies
considerations of “Now that we have a
treatment options better understanding
should account for of your situation, can
risks we explore and come
up with a plan of
action to improve
things?”
Explore all treatment
options
Agree Agree on realistic Most patients and The agree step is

weightloss many physicians have about respectful
expectations and unrealistic negotiation to achieve
targets, behavioural expectations; “best weight” focused
changes using the interventions should on SMART goals and
SMART framework,61 focus on changing health outcomes
behaviour; providers
and specific details of should seek patients’ Any treatment plan
the treatment options “buy-in” to proposed should use effective
treatment behaviour modification
principles such as goal
setting and behaviour
shaping
Assist Assist in identifying Most patients have Address facilitators

and addressing substantial barriers to (motivation, support)
barriers; provide weight management; and barriers (social,
resources and assist patients are confused medical, emotional
in identifying and and cannot and economic) that
consulting with distinguish credible make weight
appropriate providers; and noncredible management
arrange regular follow sources of challenging
up information; follow up The clinician’s role is to
is an essential identify, educate,
principle of chronic recommend and
disease management support
Arrange follow up to
keep the conversation
going
Abbreviations: BMI = body mass index; SMART = specific, measurable, achievable, rewarding, timely; WC = waist
circumference
Adapted with permission from Vallis M, Piccinini-Vallis H, Sharma AM et al. Clinical review: modified 5 As: minimal intervention for obesity
counseling in primary care. Can Fam Physician 2013;59:27-31.
Diet Therapy
Calorie Restriction
There is strong evidence that low-calorie diets consisting of approximately 1000–1200 kcal per day
can reduce body weight by an average of 8% over 3–12 months.62 If caloric intake is reduced by 500
kcal per day, it will result in weight loss of approximately 0.5 kg per week. The diet must be
nutritionally adequate (diets under 1100 kcal per day may not contain adequate amounts of vitamins
and minerals; supplementation may be recommended). Eating less than 1000 kcal per day long term
is not recommended as compliance is difficult. It may cause a reduction in resting metabolic rate,
promoting weight regain upon cessation of energy restriction.25
Reduced-calorie diets result in clinically meaningful weight loss regardless of whether they
emphasize protein, fat or carbohydrates.63,64 Even in overweight or obese children and adolescents,
the dietary macronutrient distribution of a reduced-energy diet is not important, as improved weight
status can be achieved regardless.65 Since weight loss among diets is similar, the best option is to
recommend any diet that a patient will adhere to.
See Table 8 for a comparison of macronutrient and calorie content of various diets.
Table 8: Nutrient Content of Canada's Food Guide Compared with Other Diets
Diet Kilocalories/Day Total Saturated Protein CHO Fibre
Fat Fat (%) (%) (g)
(%) (%)
Canada's Food 1800 30 10 15 55 30
Guide
Typical American 2200 35 16 15 50 9

Diet66
Weight 1462 25 6 20 56 26
Watchers66
Dr. Atkins 1800 60a 18 30b 10 10

(New Diet
Revolution)66,67,68
The Zone69 1000 30 8 30b 40 10
Carbohydrate 1476 54a 24 23b 24 8

Addict's
Sugar Busters70 1521 28 7 33b 39 25
Dr. Ornish66,71 1273 9 2 15 81c 38
Mediterranean 2000 37 9 15 43 31
Diet72
a High-fat diet.
b High-protein diet.
c High-carbohydrate diet.
Abbreviations: CHO = carbohydrate
Diet Types
Very-low-calorie Diets
Very-low-calorie diets are usually liquid diets that supply about 400–800 kcal per day and produce
rapid weight loss while minimizing the protein losses of starvation.73 They are recommended only
for obese patients (BMI ≥30) and must only be administered under close medical supervision.
When rapid weight loss (achieved with very-low-calorie diet) was compared with slower weight
loss (achieved with low-energy diets), there was no significant difference with respect to weight
loss at the end of long-term follow up.74 Evidence from randomized trials shows a greater initial
weight loss may result in improved sustained weight maintenance.75 Examples include the
Cambridge, Optifast, Dr. Bernstein's and hCG (human chorionic gonadotropin) diets.
High-protein, Low-carbohydrate Diets
High-protein, low-carbohydrate diets are based on the idea that by limiting the amount of
carbohydrate, the body is forced to burn stored fat. There is no scientific evidence for this and
high-protein diets may increase bone calcium loss.66 These diets can also trigger ketosis, which
could lead to dehydration, gout, orthostatic hypotension and electrolyte imbalance, and possibly
result in kidney and liver damage.25 Weight loss induced by high-protein, low-carbohydrate diets is
largely attributable to loss of water, glycogen and lean tissue. Adverse effects include headache,
bad breath and constipation.
At 3 and 6 months, there is greater weight loss than with low-fat diets but the difference is no
longer significant after 1 year. Low-carbohydrate diets are associated with unfavourable changes
in total cholesterol and LDL-C but favourable changes in TG (triglycerides) and HDL-C. The long-
term benefit is not known as diets high in protein are generally higher in fat, and therefore effects
on heart disease, colorectal conditions and cancer are yet to be determined. A systematic review
could not recommend use for or against a low-carbohydrate diet.76 Examples include the
Montignac Diet, the Carbohydrate Addict's Lifespan Program, Dr. Atkins New Diet Revolution and
Protein Power.67,68
Low-fat Diets
Low-fat diets produce significant weight loss for up to 3 years. A 2012 review concluded that low-
fat and energy-reduced diets are comparable in terms of weight loss. Low-fat diets are most
successful in maintaining weight loss. A diet high in vegetables, fruits, complex carbohydrates
(whole grains and legumes) and low-fat dairy is a moderate-fat, low-calorie diet that prevents
weight gain and results in weight loss and weight maintenance. Fewer patients drop out from a
low-fat diet than a low-carbohydrate diet, suggesting that energy from carbohydrate is more
satiating than from fat.77,78 Weight Watchers is an example of this type of diet.
High-fibre, Low-glycemic-index Diets
These diets promote weight loss through consumption of large amounts of fibre. Increasing
dietary fibre may facilitate weight loss.79 Both soluble fibre (e.g., pectins, gums, psyllium, oat
bran) and insoluble fibre (e.g., cellulose, lignins) promote satiety by delaying gastric emptying and
causing a feeling of fullness.80 Insoluble fibre adds bulk and increases water in the stool, which
speeds the passage of food through the intestinal tract, allowing less time for absorption of
nutrients.81 Examples include Dr. Ornish's Eat More, Weigh Less and Dr. Bob Arnot's Revolutionary
Weight Control Program.
Glycemic index is a term used to compare the blood glucose response to ingestion of 50 g of
available carbohydrate from a test food with that of a reference food (either glucose or white
bread). When foods with a higher glycemic index are eaten, they produce more of an insulin spike
than foods with a lower glycemic index. This may be followed by reactive hypoglycemia and
eventually insulin resistance. An index greater than 50 denotes a high-index food. Examples are:
white bread (73), baked potato (85), corn flakes (85), bananas (52). Low-glycemic-index foods
(<50) include: All-Bran (42), apples (38), lentils (29), carrots (47).82
Glycemic load may be more important than glycemic index.83 Glycemic load takes into account
the amount of carbohydrate in the food portion. For example, watermelon has a high glycemic
index (72); however, since only 5% of watermelon is carbohydrate it actually has a low glycemic
load (3.6). A glycemic load of less than 10 is considered low.
A systematic review on the effects of high-glycemic-index and low-glycemic-index foods on

appetite and energy balance did not show a difference.84 When a high-glycemic-load diet was
compared with a low-glycemic-load diet, the long-term weight loss was similar.85 Use of glycemic
index is not endorsed by the American Diabetic Association. However, consumption of lower-
glycemic-index foods (whole grains) is encouraged. Examples of low-glycemic-index diets for
weight management include the GI Diet; Good Carbs, Bad Carbs; and the South Beach Diet.
Mediterranean Diet
While there are variations in the definition of a Mediterranean diet, it is generally characterized by
high intake of extra virgin (cold pressed) olive oil and plant foods (vegetables including leafy
greens, fruits, cereals, nuts and pulses/legumes), moderate intake of fish, poultry, dairy and red
wine, and low intake of red meat, eggs and sweets.72 Adherence to a Mediterranean-type diet has
been associated with longer survival, reduced risk of cardiovascular or cancer mortality and
reduced risk of neurodegenerative disease.86 Compared with low-carbohydrate diets, the
Mediterranean diet showed similar effect on weight and more favorable effect on glycemic
control.87 A subgroup analysis of the PREDIMED trial that looked at the potential health benefits
of a Mediterranean diet supplemented with either extra-virgin olive oil or nuts compared with a
control diet (advice on a low-fat diet) showed that a Mediterranean diet supplemented with extra-
virgin olive oil reduced diabetes risk among persons with high cardiovascular risk.88 Similarly, a
Mediterranean diet enriched with extra-virgin olive oil or nuts resulted in a decrease in diastolic
blood pressure compared with the control diet89 and was more likely to cause reversion of the
metabolic syndrome.90
Food-specific Diets
These diets make the unfounded claim that some foods have special properties that can cause
weight loss. Eventually boredom sets in and one stops eating the allowed food, or at least enough
of the allowed food to maintain weight. Examples include the Blood Type Diet, GenoType Diet,
Dukan Diet, Paleo Diet, Abs Diet and Wheat Belly Diet.
The Blood Type Diet and GenoType Diet advise tailoring diet and lifestyle to correspond to blood
type or genetic make up; e.g., those with blood type A are advised to follow a vegetarian diet.91
The Dukan Diet is a high-protein diet in which one eats specific food in phases, e.g., in the first
phase, one consumes only high protein for a week; in the second phase, vegetables are allowed.92
The Paleo Diet suggests eating only natural foods that our ancestors have hunted, fished and
gathered (no processed food, modern grains or dairy) and eating until full.93 The Abs Diet
promotes building muscle to increase the metabolism of fat. It limits the diet to 12 “power foods”
including nuts, fruits, beans, low-fat dairy, whole-grain bread, eggs, turkey and whey protein.94
Strength training and cardiovascular and abdominal exercises are essential. The Wheat Belly Diet
suggests that consuming genetically modified wheat is the cause of being overweight and calls
for the elimination of all wheat products.95
Fasting
Fasting to cleanse the body and jump-start weight loss has traditionally been used. But fasting
deprives the body of nutrients and results in low energy, weakness and light-headedness. Any
weight loss is water and muscle, not fat, and weight will be regained when eating is started again.
It does not clear toxins from the body; rather, ketones can build up when carbohydrates are not
available for energy.25
Canadian Guidelines for Diet Therapy
The 2006 Canadian guidelines on the management and prevention of obesity recommend that a
nutritionally balanced diet (designed to reduce energy intake) be combined with other supportive
interventions. They suggest a high-protein or a low-fat diet (within acceptable macronutrient
distribution ranges indicated in the Dietary Reference Intakes—see Table 9) as a reasonable short-
term (6–12 months) treatment option for obese adults as part of their weight-loss program.1
a
Table 9: Dietary Reference Intakes for Macronutrients
Age Total Total Total Omega-6 Omega-3
Group Carbohydrate Protein Fat Polyunsaturated Polyunsaturated
(males (% Energy) (% (% Fatty Acids Fatty Acids
and Energy) Energy) (linoleic acid) (α-linolenic
females)b (% Energy) acid)
(% Energyc)
1–3 y 45–65 5–20 30–40 5–10 0.6–1.2
4–18 y 45–65 10–30 25–35 5–10 0.6–1.2
≥19 y 45–65 10–35 20–35 5–10 0.6–1.2
a These are reference values for normal, apparently healthy individuals eating a typical mixed North American
diet. An individual may have physiological, health or lifestyle characteristics that may require tailoring of
specific nutrient values.
b Includes pregnant and breastfeeding women.
c Up to 10% of the allowed macronutrient dietary reference can be consumed as eicosapentaenoic acid (EPA)
and/or docosahexaenoic acid (DHA).
© All rights reserved. Dietary Reference Intake Tables. Health Canada, 2006. Reproduced with permission from the Minister of
Health, 2016. Available from: www.hc-sc.gc.ca/fn-an/nutrition/reference/table/ref_macronutr_tbl-eng.php.
For successful weight loss, consume a diet that is:
Energy-reduced (500 kcal less per day)

High-protein (within dietary reference value: 10–35%), emphasizing lean protein
Low-fat (within dietary reference values: 20–35%); decrease saturated fat (<10%), emphasize
mono- and poly-unsaturated fats
Low-glycemic-index (carbohydrate within dietary reference values: 45–65%)
High-fibre (30 g/day), whole grains.
Other Lifestyle Therapies
Physical Activity/Exercise
Physical activity plus diet produces more weight loss than either diet or physical activity alone.1 The
Canadian Society for Exercise Physiology and Health Canada established an overall goal for
individual Canadians to accumulate at least 60 minutes of physical activity every day (in periods of at
least 10 minutes each) to stay healthy or to improve health.25 Exercise reduces obesity and related
glucose tolerance and while aerobic exercise (e.g., walking, running) is the most effective for burning
fat, it was found that similar reductions in abdominal obesity occur with fixed amounts of exercise,
whether of high or low intensity.96 While walking is safe for most ambulatory people, the Physical
Activity Readiness Questionnaire for Everyone (PAR-Q+) can be used to determine whether medical
evaluation is required before becoming more physically active (see Resource Tips).
Behavioural Modification
The goal of behavioural modification is to reduce, change or eradicate lifestyle habits that have
caused or contributed to weight gain. Through maintenance of a diary, patients become aware of
what and how much they eat as a background for changing that behaviour. The aim is to break
learned associations between environmental cues and food intake. Strategies include self-
monitoring, eating “mindfully” (slower meals, with increased attention to the food and greater
awareness of hunger and satiety cues), physical activity, stress management, stimulus control,
problem solving, contingency management, cognitive restructuring and social support.97,98,99
Interventions that incorporate these strategies produce gradual and moderate weight loss.100 With
systematic manipulation of all factors associated with eating and exercise patterns, there is evidence
that with an average length of 18 weeks of treatment, an average weight loss of 9.9 kg is obtained.101
Patients are able to maintain, on average, about two-thirds of their initial weight loss 9–10 months
after behavioural counselling ends.102 Additionally, interventions that initiate behavioural
modification before implementing a weight-loss program result in improved weight maintenance.103
Size Acceptance
It is important to help people realize that there is no ideal body size, shape or weight for an individual
and that people of all sizes and shapes can reduce their risk of poor health by adopting a healthy
lifestyle.25
Weight Maintenance and Prevention of Weight Regain
The maintenance of a reduced body weight is difficult. After 6 months, the rate of weight loss usually
declines and plateaus.1 Successful weight maintenance is defined as a weight regain of <3 kg in 2
years and a sustained reduction in waist circumference of at least 4 cm. Patients on a calorie-
reduced diet experience a 15–20% drop in metabolic rate.104 This reduced metabolic rate may also
make it easier to regain weight upon returning to a less restrictive diet. To combat this, the American
College of Sports Medicine (ACSM) recommends >250 minutes/week of moderate-intensity physical
activity to prevent weight regain.105 Ultimately, dietary therapy, physical activity and behaviour therapy
must be continued indefinitely after weight loss; otherwise weight will likely be regained.1
Weight Loss Programs
A number of self-help programs such as Weight Watchers, NutriSystem, Overeaters Anonymous and
Take Off Pounds Sensibly (TOPS) offer support and motivation (see Resource Tips).
Technology-based weight loss programs offer patients convenient tools (e.g., personal digital
assistants (PDAs), mobile phones, tablets or computers) to self-monitor their diet106 and physical
activity107 and technology engages the younger population, who are comfortable with and often
prefer electronic media.108 Additionally, connective mobile technology allows patients to transmit
diet and physical activity information to a healthcare practitioner or coach, who can provide feedback
and support. The addition of a PDA and telephone coaching to an intensive group weight loss
program demonstrated that the PDA-based group achieved significantly greater weight loss than the
standard-care group.109 Mobile telephone interventions have also been proven to be an effective
strategy for promoting weight loss. The interventions studied included contact by text messages
(text, pictures or other multimedia) that delivered frequent reminders of nutrition and physical activity
goals and recommendations.110
Health and fitness apps on smartphones are able to collect data on diet, exercise and sleep habits
from user entry and from the phones' built-in tools, such as the Global Positioning System (GPS),
accelerometer, microphone, speaker and camera. The apps can analyze the data, develop
personalized programs, track effort and results, provide feedback, coaching and motivation, and even
share results on social media, which may facilitate behaviour change through social support,
camaraderie, competition and accountability.111 A randomized controlled trial that examined the
effect of mobile phone technology on weight loss and diabetes prevention showed that a combined
smartphone app and pedometer intervention resulted in significant weight loss vs. control.112
Another trial examined acceptability and feasibility of a self-monitoring weight management
intervention delivered by a smartphone app compared with a website or paper diary and found both
adherence and weight loss were greater with the smartphone app.113 Popular weight management
apps include MyFitnessPal, Fitocracy, Fooducate, FitBit, Noom Coach: Weight Loss, Lose It!,
MapMyFitness, Nike+ Running, RunKeeper, and Runtastic.111
While technology-based weight loss warrants further study to determine effectiveness in changing
patients' behaviours and improving their well-being, and to identify which specific aspects (e.g.,
convenience, personalization, interactivity or cost-effectiveness) make it successful for weight loss, it
has potential for a wide range of uses in weight management and health improvement.111,114
Surgery
Bariatric or weight-reduction surgery is considered for people with a BMI >40, or BMI 35–40
combined with high-risk comorbid conditions, and whose obesity is refractory to other approaches.1
Surgical treatment of obesity is based on 1 of 2 principles:
A short bowel is created to produce malabsorption of ingested calories (gastric bypass), or

A small stomach is created to prevent large caloric intake at any one time (banded gastroplasty
and vertical sleeve gastrectomy).
Bariatric surgery for obesity, such as gastric bypass, gastric banding and sleeve gastrectomy, results
in greater improvement in weight loss outcomes and weight-associated comorbidities compared with
nonsurgical interventions, regardless of the type of procedures used.115,116 Bariatric surgery
demonstrates more efficient prevention of type 2 diabetes than usual care (lifestyle interventions
combined with antiobesity medications), particularly in patients with impaired fasting glucose.117 It
is also associated with a significant reduction of cardiovascular deaths and lower incidence of
cardiovascular events in obese adults when compared with usual care.118
When comparing different types of bariatric surgeries, long-term outcomes (weight loss, type 2
diabetes control and remission, hypertension and hyperlipidemia) are better with gastric bypass than
with gastric band procedures in severely obese adults.119 Adolescents with severe obesity obtained
substantial weight loss and improvement of comorbidities with an acceptable complication rate with
all three bariatric procedures120 and improvements in weight, cardiometabolic health and weight-
related quality of life have been maintained for 3 years after gastric bypass or sleeve gastrectomy.121
Patients who undergo bariatric surgery are likely to need lifelong medical supervision.122
Complications of bariatric surgery include wound healing, metabolic disturbances, severe diarrhea,
bloating and anorectal pain. Drug-related complications arise postoperatively; the most common are
listed below.
Drug-related management after bariatric surgery:123
Potential malabsorption of bisphosphonates, calcium, iron, thiamine, vitamin B12 and vitamin D.
Other nutrients may be involved, depending on the type of surgery.
Immediate-release formulations may be more effective than extended-release.
Monitor for changes in the dose requirements of digoxin, levothyroxine, erythromycin (do not
use base formulations), warfarin.
Hypertension, dyslipidemia and diabetes may improve and require less treatment.
Diuretics should be discontinued or reduced in dosage for the first 1–2 months postoperatively
to avoid dehydration and electrolyte abnormalities.
Antihyperglycemic therapies should be reduced in dosage postoperatively to avoid
hypoglycemia.
Liposuction, a cosmetic surgical procedure, removes fat to reshape the body. It removes some fat
cells, but a compensatory hypertrophy of remaining adipose tissue after lipectomy has been
demonstrated.122 There are risks such as blood clots, perforation injuries and skin and nerve
damage. Liposuction has no impact on eating habits.
For further discussion of pharmacologic therapy for weight-loss, consult the Compendium of Therapeutic
Choices: Obesity.
Dietary Products
Meal Replacements
Minor Ailments—Nutrition Products: Adult Nutrition Products.
One or 2 meals per day are replaced with a portion-controlled food item such as a shake or bar, e.g.,
Slim-Fast, Ensure, Boost. As a result, dieters have to make fewer choices. Compared with a
conventional reduced-calorie diet, where the weight loss was 3–7% of initial body weight over 3
months to 1 year, patients using meal replacements lost 7–8%.124
Fat Substitutes
Fat substitutes are carbohydrate-, protein- or lipid-based. The carbohydrate- and protein-based
products provide less than the usual 9 kcal per gram of fat. They allow incorporation of extra water
into foods by binding to it, which decreases the calories per serving. They have a moist, thick texture
which mimics the richness of fat. Carbohydrate-based fat substitutes include dextrans,
maltodextrans, gums, pectin, cellulose and β-glucan. Protein-based products use whey protein
combined with egg white (Simpless, available in the United States). The fatty acids in lipid-based fat
substitutes are arranged on the glycerol molecule in order to inhibit absorption. Olestra is a lipid-
based product available in the United States. Long-term benefits and safety are unknown.
“Low-fat foods” should not be confused with “low-calorie foods”; the calories saved by eating low-fat
foods are often negligible, especially if more is eaten in compensation.25,125 In addition, low-fat
foods (dessert/snacks) may be high-calorie due to the addition of extra sugars to compensate for the
loss of texture and flavour from fat.
Artificial Sweeteners
Nutritive sweeteners include sorbitol, mannitol and xylitol, which are sugar alcohols. They contain
about half the calories of sugar because the body absorbs them more slowly and incompletely. The
side effect of this slow absorption is diarrhea. Natural sweeteners are nutritive sweeteners which
contain the same number of calories as table sugar. Natural sweeteners include date sugar, grape
juice concentrate, honey, maple sugar, maple syrup, molasses and agave nectar. They are promoted
as healthier options than processed table sugar or other sugar substitutes, even though many
undergo processing and refining. Be aware that honey may contain small amounts of bacterial spores
that can produce botulism toxin and should not be given to babies under 1 year old. Choose a natural
sweetener based on its taste and uses rather than on its health claims, as glucose and fructose are
the end-products of both natural sweeteners and table sugar.
Non-nutritive sweeteners include saccharin, aspartame, acesulfame potassium (acesulfame K),

sucralose, cyclamate, neotame and the herb stevia. They are so intensely sweet that tiny amounts
can be used, so the calories they provide are undetectable (Table 10). If used as substitutes for
higher energy yielding sweeteners, there is a potential to aid in weight management,128 but if there is
no energy restriction (no reduction of calories), the addition of non-nutritive sweeteners to the diet
poses no benefit for weight loss or reduced weight gain. Use of non-nutritive sweeteners may also
promote a preference for foods and beverages that have a sweeter taste. Some research suggests
that artificial sweeteners may actually contribute to weight gain,129,130 and in the MESA study (Multi-
Ethnic Study of Atherosclerosis), daily diet soda consumption was associated with a significantly
greater risk of incident metabolic syndrome (high waist circumference and fasting glucose) and type
2 diabetes than nonconsumption.131 A 2014 study published in Nature showed that artificial
sweeteners (saccharin, sucralose, aspartame) induced glucose intolerance by altering the intestinal
microbiota. This resulted in a metabolic disorder in both mice and humans.132 A 2016 systematic
review concluded artificial sweeteners do not increase energy intake or body weight.133 Given the
conflicting evidence on their effect on weight management and the lack of evidence on long-term
health consequences, more research on artificial sweeteners is required.
126,127
Table 10: Artificial Sweeteners
Product Kilocalories/g Sweetness Acceptable Comments
Compared Daily Intakea
with Sugar (mg/kg body
weight)
Acesulfame 0 200× 15 Caution if sulfa
K allergy.
Contains potassium
—caution in
potassium-restricted
diets.
Aspartame 4 160–220× 40 Contraindicated in

(so sweet that patients with
very little is phenylketonuria.
used) Allergy possible.
No adverse effects
normally associated
with ingestion of less
than 50 mg/kg/day.
Cyclamate 0 30× 11 Acceptable daily

intake is up to 4 mg.
Large doses cause
diarrhea.
Photosensitivity has
been reported.
Neotame 7 7000–13 18 Chemically related to

000× aspartame.
Does not contain
phenylalanine; not
contraindicated in
phenylketonuria.
Product Kilocalories/g Sweetness Acceptable Comments
Compared Daily Intakea
with Sugar (mg/kg body
weight)
Saccharin 0 300–500× 5 Schedule III—
permitted only as a
tabletop sweetener
due to risk of
carcinogenesis in
rats (not shown in
humans). Health
Canada is
reconsidering
allowance in foods.
Sucralose 0 600× 15 Used to replace

sugar 1:1 in baking.
Passes through the
body intact.
Splenda contains
sucralose, dextrose
and maltodextrin and
may substitute for
sugar in baking (1:1).
It contains some
calories due to the
added sugars; may
alter drug
absorption.
Xylitol, Approximately 0.5× Not available Not readily absorbed

sorbitol, 2 but very little and can cause
mannitol is absorbed, osmotic diarrhea.
therefore
virtually no
calories
Stevia 0 300× 0–4 (as steviol) In Canada, stevia leaf

(Stevia and its crude
rebaudiana) extracts are available
as food ingredients
and NHPs; purified
stevia extract is
available as a food
additive.
a Acceptable Daily Intake from the Joint Commission of Experts on Food Additives of the World Health
Organization.
Selected Weight-loss Products

Ailments—Gastrointestinal Products: Laxatives; Herbal and Natural Health Products: Combinations,
Single Entity; Nutrition Products: Weight Control; Vitamin and Mineral Products: Single Entity.
Several weight-loss products have been used to assist patients in achieving weight loss with varying
levels of evidence for clinical efficacy (see Table 11).
25,127
Table 11: Weight-loss Products with Limited Evidence of Efficacy
Class Product Mechanism Dose Adverse Comments
of Action Effects
Fibre psyllium Delayed 10 Cramping, Clinical trials
(Plantago gastric g/day bloating, needed to
psyllium) emptying in flatulence, evaluate efficacy.
creates a divided blockage of Similar effect
feeling of doses esophagus, may be obtained
fullness and po intestine or by eating high-
satiety fecal impaction fibre vegetables
if not taken and fruits.
with sufficient
fluid.
Allergy to
psyllium.
glucomannan Soluble fibre 1.2–3 General Glucomannan

(Amorphophallus promotes g/day gastrointestinal use results in
konjac) satiety, po discomfort. weight and fat
increases fat Esophageal loss in adults
metabolism obstruction and children in
possible. most
studies.134,135
Safety not
established.
Natural hydroxycitric Prevents 500 mg Upper Weight loss in

Health acid (Garcinia storage of TID po respiratory trials only slightly
Products cambogia) excess tract higher than
calories as symptoms, placebo or no
fat, may nausea, GI difference.136,137
suppress discomfort, Safety not
appetite headache. established.
green tea Thermogenic 100– Sympathetic Cochrane

750 stimulation due systematic
mg/day to caffeine review showed
po content (see small,
caffeine statistically
below). nonsignificant,
Tannins cause positive effect on
constipation. weight loss.
More
pronounced
effect in
Japanese
population.138
Catechin content
may be more
important than
caffeine content.
of Action Effects
Hoodia gordonii Appetite 400– None reported. Anecdotal
suppressant 800 evidence.139
mg/day
po
Stimulants caffeine Anorectic, 200 mg Sympathetic All studies done

thermogenic, TID po stimulation, in combination
diuretic insomnia, with ephedra
nervousness, (banned in
tachycardia, Canada).140,141
headache, Herbal products
anxiety, etc. containing
caffeine include
tea, guarana and
yerba mate.
Minerals calcium Unknown 1000– Belching, Studies have

mechanism; 1500 flatulence. shown:
may increase mg/day Constipation - 1500 mg/day
metabolism po possible with failed to show
of fat or CaCO3. efficacy in weight
decrease
desire to eat loss142
- 800 mg dairy
calcium did not
affect energy
expenditure or
fat burning143
- weight loss only
in people who
are calcium
deficient144
- more research
needed.
chromium Increases 100– Nausea, A Cochrane

picolinate basal 500 µg vomiting, systematic
metabolic BID po stomach review found no
rate (BMR) discomfort. reliable evidence
of the efficacy
and safety of
chromium
picolinate in
overweight or
obese adults.145
of Action Effects
Topical benzocaine Local 3–4 mg Numbs oral Clinical trials
Anesthetics anesthetic in gum, cavity and needed to
numbs the lozenge gastric assess efficacy.
oral cavity to or mucosa.
decrease tablets; Topical
taste chew anesthesia
sensation gum or may impair
suck swallowing and
tablets increase risk of
30 min aspiration.
before Numbness of
meals tongue may
po increase risk of
biting trauma.
Various apple cider Unknown 1 oz Long-term risk No available

vinegar (30 mL) of studies. Safety
cider hypokalemia, not established.
+ 1 tsp decreased
(5 mL) bone density,
honey may destroy
tooth enamel.
in 1–4 If undiluted,
oz (30– may harm the
120 esophagus and
mL) stomach.
water
before
each
meal
po
chitosan Decreases 1.35 g Constipation A Cochrane

absorption TID po and flatulence. review concluded
of fat Derived from minimal effect
shellfish on body
(watch weight.146
allergies).
conjugated Suggested to 0.7–4.5 Diarrhea, Affects body

linoleic acid reduce body g/day nausea and composition
(CLA) fat po dyspepsia. rather than body
weight.147
Warrants further
research.
pyruvate Unknown; 3–5 Stomach upset Small weight

purported to g/day and diarrhea. loss of 0.8–1.6
increase po kg compared
metabolism with placebo.148
and fat Safety not
utilization established.
Orlistat inhibits fat absorption in the intestine by blocking pancreatic lipase. As a result, about 30% of
ingested fat is passed in the stool. Side effects include loose and oily stools (especially if a low-fat diet is
not consumed), fecal incontinence, abdominal cramping and nausea. Weight loss on average is 2.9%
greater than placebo over 6–12 months and continued therapy can maintain the lower weight for up to 2
years. It can reduce the absorption of fat-soluble vitamins (A, D, E and K), and therefore supplementation
is recommended.149
Liraglutide stimulates insulin secretion, reduces postprandial glucagon levels, slows gastric emptying
and reduces appetite. The most common side effects include nausea, vomiting, diarrhea and
constipation. In conjunction with diet and lifestyle interventions, patients on liraglutide achieved and
maintained an average weight loss of 8 kg through 2 years of therapy. Adjustment of concomitant
diabetes medications may be required to prevent potentially severe hypoglycemia.150,151,152,153
Inappropriate Medications for Weight Loss

Syrup of ipecac: People with eating disorders sometimes misuse syrup of ipecac to induce vomiting.
Repeated use can cause cardiotoxicity and dental erosion due to acidic stomach contents.
Laxatives: Laxatives are used to speed up the passage of food through the GI tract to decrease the
absorption of calories. However, they have little or no effect on reducing weight, as the ingested calories
have already been absorbed by the time the laxative takes effect. Prolonged use of laxatives causes
electrolyte imbalances and suppresses the natural urge to defecate, leading to constipation.
Diuretics: An initial weight loss is due to dehydration but continued use causes electrolyte imbalances.
Ephedra (Ma Huang): The US Food and Drug Administration and Health Canada have issued warnings about
the use of ephedra for weight loss, bodybuilding or increasing energy.154,155 Ephedrine increases the release
of norepinephrine, which suppresses appetite, enhances thermogenesis and speeds up metabolism. Side
effects include insomnia, nervousness, seizures, stroke, heart attack and even death. Ephedra is authorized
by Health Canada for use only as a nasal decongestant in cold products. These products have smaller
dosages and are less likely to be abused.155 Watch for hidden sources of ephedrine in bitter orange (Citrus
aurantium), country mallow or heartleaf (Sida cordifolia).
Thermogenic agents: Thyroid hormone is touted as a treatment for obesity because of its thermogenic
properties. However, there are serious and potentially life-threatening consequences of elevating thyroid
hormone levels beyond the normal range. Thyroid hormones should be avoided unless there is a confirmed
thyroid deficiency.127
Evaluate at 6 months to determine success and assess further need for additional weight loss. If
necessary, refer to a dietitian, exercise physiologist, psychologist and/or other healthcare practitioner if
there is no success in weight reduction.
Assess whether patient has been able to reach and maintain a healthy weight range (BMI of 18.5–
24.9).
If patient is on medication for obesity, assess medication tolerance and maintenance of improved diet
and activity.
.....
Underweight
Introduction
Underweight is defined as:4
Adults >19 years: BMI <18.5
Children and adolescents 2–19 years: BMI-for-age <5th percentile
Children <2 years: weight-for-length <5th percentile
Prevalence
In 2008, the prevalence of underweight in Canada was 2.6% for females and 1.4% for males aged 18 and
older.156 In the United States, the prevalence decreased from an estimated 4% in the early 1960s to
approximately 2% in 2003–2006 among all age groups.157 The WHO focuses on underweight
(malnourished) children in underdeveloped countries and states that the prevalence is dropping.158
Health Risks
Malnourishment; in children, slowed growth, delayed development and a high rate of illness can
occur
Osteoporosis
Infertility, amenorrhea
Impaired immunocompetence—increased infections
Pathophysiology
The most common reason for being underweight is malnutrition caused by the unavailability of adequate
food. The elderly are particularly prone to being malnourished as are infants and adolescents, who are in
rapid periods of growth. Those suffering from eating disorders (anorexia nervosa, bulimia nervosa, binge
eating—see Eating Disorders), chronic diseases such as HIV/AIDS and those with poor eating habits are
likely to be malnourished. Physical, physiological and psychological factors play a role.159
Causes of malnutrition include:
Poverty
Diseases that reduce appetite, decrease absorption or utilization of nutrients (e.g., cancer) or increase
requirements for nutrients
Drugs that cause nausea and vomiting (see Nausea and Vomiting) and/or affect absorption, utilization
or excretion of nutrients
Ignorance about good nutrition or food preparation
Dental problems
Depression or mental health issues
Decreased physical ability to buy food or prepare a meal
Alcoholism
Eating disorders.
Goals of Therapy
Achieve and maintain a healthy weight (BMI between 18.5 and 24.9)
Treat the underlying cause
Provide adequate nutrient intake
Prevent complications associated with being underweight
Patient Assessment
Assess the individual's weight status (BMI) and risk factors above
Determine any underlying cause
Assess diet
Assess physical activity history
Patients who are underweight can increase nutrient intake by eating at mealtime, increasing the number and
size of servings, increasing nutrient density by adding extra protein, carbohydrate and fat and by eating more
frequently. Restricting physical exercise so there is a positive energy balance can be beneficial, as can
behaviour modification. It is best to increase body weight gradually (approximately 0.5 kg weekly). Referral
to a dietitian for an in-depth diet assessment would be appropriate.
Appetite Stimulants
Oxandrolone, corticosteroids, cyproheptadine, megesterol acetate and dronabinol are appetite stimulants
used largely in cancer-associated anorexia (cachexia).
Assess whether patient has been able to reach and maintain a healthy weight (BMI 18.5–24.9)
If patient is on medication for being underweight, assess tolerance as well as whether patient is
sustaining improved diet and activity patterns.
.....
Eating Disorders
Overview
For further discussion of management of eating disorders, consult the Compendium of Therapeutic Choices:
Eating Disorders.
Anorexia nervosa (see Table 12) is characterized by 3 essential features: persistent restriction of energy
intake that leads to significantly low body weight; intense fear of gaining weight or of becoming fat, or
persistent behavior that interferes with weight gain despite being at a significantly low weight; and a
disturbance in self-perceived weight or shape. Individuals maintain a body weight that is below a minimally
normal level for age, sex, development and physical health and do not recognize the seriousness of the low
body weight.160
Bulimia nervosa (see Table 12) is characterized by recurrent episodes of binge eating, inappropriate
compensatory behaviors to prevent weight gain (purging) and self-evaluation that is unduly influenced by
body shape and weight. Binge eating involves eating an amount of food within a set time period (e.g., 2
hours) which is larger than what most individuals would eat under similar circumstances and is
accompanied by a sense of lack of control over eating. Purging includes self-induced vomiting; misuse of
laxatives, diuretics or other medications; fasting; or excessive exercise. A diagnosis of bulimia is made when
the binge eating and purging occurs at least once per week for 3 months. Unlike individuals with anorexia,
who are excessively thin, individuals with bulimia are typically normal weight or overweight.160
Binge-eating disorder is also characterized by episodes of binge eating that occur at least once per week for
3 months; however, it is not associated with the use of compensatory behaviors to prevent weight gain. In
binge-eating disorder, there is a marked distress regarding the binge eating and the binge eating episodes
are associated with eating more rapidly than normal, eating until feeling uncomfortably full, eating large
amounts of food when not physically hungry, eating alone due to feeling embarrassed by the amount of food
being consumed and feeling disgusted with oneself, depressed or very guilty afterwards.160
Health practitioners should lead efforts to prevent eating disorders by learning to promote self-esteem in
their patients and teaching patients to focus on health vs. size. Warn patients of the potential dangers of
inappropriate methods of weight loss, including medications (see Inappropriate Medications for Weight
Loss).
161
Table 12: Warning Signs of Anorexia and Bulimia Nervosa
Anorexia Bulimia
Loss of significant amount of weight Bingeing, or eating uncontrollably

Continuing to diet (although thin) Purging by strict dieting, fasting, vigorous exercise,
Feeling fat, even after losing weight vomiting or abusing laxatives or diuretics in an
attempt to lose weight
Fear of weight gain
Using the bathroom frequently after meals
Cessation of monthly menstrual periods
Preoccupation with body weight
Preoccupation with food, calories, nutrition
and/or cooking Depression or mood swings
Preferring to eat in isolation Irregular menstrual periods
Exercising compulsively Dental problems, swollen cheeks or glands,

heartburn or bloating
Bingeing and purging
.....
Algorithms
Figure 1: Algorithm for the Assessment and Stepwise Management of the Overweight or Obese Adult
a Body mass index (BMI) and waist circumference cut-off points are different for some ethnic groups; see Table 3
for ethnicity-specific waist circumference cut-off points.
Abbreviations: HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol

Adapted with permission from Lau DC, Douketis JD, Morrison KM et al. 2006 Canadian clinical practice guidelines on the management
and prevention of obesity in adults and children. CMAJ 2007;176:SS1-117.
Resource Tips
Calculation of Body Mass Index (BMI)
Canadian Diabetes Association. Body Mass Index (BMI) calculator. Available from:
www.diabetes.ca/diabetes-and-you/healthy-living-resources/weight-management/body-mass-index-bmi-
calculator.
Health Canada. Body Mass Index (BMI) nomogram. Available from: www.hc-sc.gc.ca/fn-
an/nutrition/weights-poids/guide-ld-adult/bmi_chart_java-graph_imc_java-eng.php.
Eating Disorders
National Eating Disorder Information Centre (NEDIC). Available from: www.nedic.ca. Telephone: 416-340-
4156.
National Eating Disorders Association. (NEDA). Available from: www.nationaleatingdisorders.org.
Obesity
Canadian Obesity Network. Available from: www.obesitynetwork.ca.
Health Canada. Eating well with Canada's food guide. Available from: www.hc-sc.gc.ca/fn-an/food-guide-
aliment/index-eng.php.
Healthy Weight Network. Available from: www.healthyweightnetwork.com.
National Center for Overcoming Overeating. Available from: www.overcomingovereating.com.
Obesity Society. Available from: www.obesity.org.
Public Health Agency of Canada. Physical activity: Tips to get active. Available from: www.phac-
aspc.gc.ca/hp-ps/hl-mvs/pa-ap/04paap-eng.php.
Physical Activity
Warburton DE, Jamnik VK, Bredin SS et al. The Physical Activity Readiness Questionnaire for everyone (2015
PAR-Q+) and electronic Physical Activity Readiness medical examination (ePARmed-X+). Health & Fitness
Journal of Canada 2011;4:3-23. Available from: www.eparmedx.com/wp-
content/uploads/2013/03/PARQplusJan2015.pdf.
Suggested Readings
Brauer P, Connor Gorber S, Shaw E et al. Recommendations for prevention of weight gain and use of
behavioural and pharmacologic interventions to manage overweight and obesity in adults in primary care.
CMAJ 2015;187:184-95.
Casazza K, Fontaine KR, Astrup A et al. Myths, presumptions, and facts about obesity. N Engl J Med
2013;368:446-54.
Freedman HR, King J, Kennedy E. Popular diets: a scientific review. Obes Res 2001;9:1S-40S.
Jensen MD, Ryan DH, Apovian CM et al. 2013 AHA/ACC/TOS guideline for the management of overweight
and obesity in adults: a report of the American College of Cardiology/American Heart Association Task
Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol 2014;63:2985-3023.
Lau DC, Douketis JD, Morrison KM et al. 2006 Canadian clinical practice guidelines on the management and
prevention of obesity in adults and children. CMAJ 2007;176:S1-117. Available from:
www.cmaj.ca/content/suppl/2007/09/04/176.8.S1.DC1/obesity-lau-onlineNEW.pdf.
National Institutes of Health; National Heart, Lung, and Blood Institute; North American Association for the
Study of Obesity. The practical guide: identification, evaluation, and treatment of overweight and obesity in
adults. October 2000. Available from: www.nhlbi.nih.gov/guidelines/obesity/prctgd_c.pdf.
Sharma AM. Obesity. In: Jovaisas B, ed. Compendium of therapeutic choices: (CTC 7). 7th ed. Ottawa:
Canadian Pharmacists Association; 2014. p. 398-410.
Strychar I. Diet in the management of weight loss. CMAJ 2006;174:56-63.
References
Drug Use and Abuse in Sports
Lily Lum, BScPharm, CSPI

Introduction
Olympic athletes of ancient Greece are believed to have used herbs and mushrooms to improve athletic
performance.1,2 Now, in the age of the modern Olympic games, athletes continue to take substances that
are not officially permitted (prohibited substances) to boost their performance and give them an advantage
to win.3
Ergogenic (performance-enhancing) drug use or doping is defined as “the administration of or use by a

competing athlete of any substance foreign to the body or of any physiological substance taken in abnormal
quantity or taken by an abnormal route of entry into the body with the sole intention of increasing in an
artificial manner his/her performance in competition.”1 Sports organizations have developed antidoping
policies and drug testing programs in order to protect the health of the athletes and to keep competition fair
and drug free.4 Although drugs carry potential adverse effects, most athletes who use them view the risk-
benefit ratio as favourable.5 Ergogenic aids come from many sources and the list often appears endless as
access to such products is easy, especially with use of the Internet. Ergogenic aids may be prescription or
nonprescription drugs, recreational drugs such as alcohol and marijuana, nutritional supplements or natural
health products.
Nonprescription Drugs
A number of agents found in nonprescription products are used as ergogenic aids (see Table 1).1,2,4,5,6,7
Table 1: Common Ergogenic Aids Found in Nonprescription Products

Evidence for
Performance
Drug/Drug Class Reason for Use Adverse Effects Enhancement
Caffeine Increased Nervousness, Inconclusive or conflicting
alertness; reduced insomnia, tremors, evidence; found in
perception of diuresis stimulants, combination
fatigue; increased analgesic products.
endurance
Codeine Treatment of pain Dizziness, Inconclusive or conflicting

allows athlete to lightheadedness, evidence; found in
participate while drowsiness, nausea or combination analgesic
injured but has vomiting, constipation products and cold
potential to further preparations.
aggravate injury
Creatine Muscle- Dizziness, diarrhea; Evidence to support in

performance liver and renal toxicity power sports but not
enhancer at high doses endurance sports.8,9,10
Cyproheptadine Promotes appetite Drowsiness No evidence to support;

and weight gain theoretical benefit based on
pharmacologic actions.
Evidence for
Performance
Drug/Drug Class Reason for Use Adverse Effects Enhancement
Sympathomimetics Increased Restlessness, No evidence to support;
(e.g., subjective energy nervousness, theoretical benefit based on
phenylephrine, (“energizing” tachycardia, pharmacologic actions.
pseudoephedrine) effect), decreased arrhythmias, Found in many cold
appetite and hypertension preparations.
increased
metabolism
Prescription Drugs
Many prescription drugs are also used as ergogenic aids (Table 2).1,2,4,5,6,7 Anabolic steroids are the best
known. They are synthetic derivatives of the male sex hormone testosterone.1 Individuals use anabolic
steroids primarily to increase muscle mass and strength. Athletes who take anabolic steroids employ
unusual dosing regimens in an attempt to increase the effects of the drugs, prevent detection or decrease
the occurrence of drug-related adverse effects. Stacking is a technique where several different anabolic
agents (oral and injectable) are used concomitantly in order to produce a synergistic effect. Cycling is a
dosing technique with on and off periods of drug use. Pyramiding is another dosing technique where low
doses are initiated, increased to a plateau 10–100 times the recommended therapeutic dose and then
tapered to the original level.1,5,11 Much of what is known about the side effects of anabolic steroids involves
patients receiving therapeutic doses for treatment of disease. The adverse effects of the high doses used in
some doping regimens are not fully understood.
Table 2: Common Ergogenic Aids Found in Prescription Products

Evidence for
Drug/Drug Performance
Class Reason for Abuse Adverse Effects Enhancement
Anabolic Increase muscle Hepatotoxicity; acne; Evidence to support.9
steroids11 mass and strength gynecomastia in males;
masculinization in
females; premature
closure of the growth
centres of long bones
(adolescents);
psychiatric effects such
as psychosis,
aggression, mood
disorders12
Beta1- Reduce anxiety, hand Dizziness or No evidence to support;

adrenergic tremor and heart rate lightheadedness; theoretical benefit based
antagonists unusual tiredness or on pharmacologic
weakness; sexual actions.
dysfunction
Beta2-agonists Anabolic effects Dizziness, Inconclusive or

lightheadedness, conflicting evidence (no
nervousness, tremor, evidence with inhaled
nausea, increased heart formulations).
rate
Evidence for
Drug/Drug Performance
Class Reason for Abuse Adverse Effects Enhancement
Diuretics Promote excretion of Dizziness or No evidence to support;
prohibited lightheadedness; theoretical benefit based
substances; decrease photosensitivity (with on pharmacologic
weight before official thiazides) actions.
weigh-ins in sports
with weight classes
(e.g., boxing, martial
arts)
Peptide Increase red blood Chest pain; shortness of Conflicting

hormones and cell production, breath; increased blood evidence.7,13,14,15
analogues: increasing aerobic pressure12
epoetin alfa capacity
(erythropoietin),
darbepoetin
Peptide Anabolic effects If growth hormone is Inconclusive or

hormones and given to children or conflicting evidence.
analogues: adults with normal
human growth growth who do not need
hormone growth hormone, serious
unwanted effects may
occur including:
development of diabetes,
abnormal growth of
bones and internal
organs such as the heart,
kidneys and liver,
atherosclerosis, and
hypertension12
Probenecid Promote urinary Headache; joint pain, No evidence to support;

excretion of a redness, or swelling; loss theoretical benefit based
prohibited substance of appetite; nausea on pharmacologic
actions.
Sildenafil, Increase oxygen Prolonged erection Inconclusive or

tadalafil supply by causing conflicting evidence.16,17
vasodilation in the
lungs
Tamoxifen Reverse Hot flushes, weight gain No evidence to support;

gynecomastia caused in females; sexual theoretical benefit based
by steroids dysfunction in males on pharmacologic
actions.
Recreational Drugs
Alcohol and marijuana may be abused by athletes with the misconception that these recreational drugs can
reduce anxiety. However, alcohol and marijuana can actually impair athletic performance.1,4 In sports
requiring precision, such as riflery events, alcohol in low doses may reduce essential tremor and is
prohibited in competition. In-competition use of Δ9-tetrahydrocannabinol (THC) and all cannabimimetics is
prohibited (see Prohibited Substances/Therapeutic Use Exemptions).
Nutritional Supplements and Natural Health Products

There are countless products (e.g., chromium picolinate, creatine) described as nutritional supplements,
herbals or natural health products with claims of possessing anabolic properties or other ergogenic
effects.7,18 Because of the known toxicity associated with anabolic steroids, natural health products are
perceived as less or not harmful, and they are also more accessible to the public. Natural health products
are often promoted in a misleading fashion and usually have no scientific evidence to support their claims of
anabolic or performance-enhancing effects.18 The Canadian Centre for Ethics in Sport (CCES) believes the
use of most supplements poses an unacceptable risk for athletes and their athletic careers.19 Supplements
may intentionally contain prohibited substances or may be inadvertently contaminated with prohibited
substances.
CCES states that athletes have a personal responsibility to consider all the risks associated with
supplements they plan to take.20 If athletes choose to use supplements, they should take the following
precautions to reduce their risk of ingesting a prohibited substance:
Get a written guarantee through a direct enquiry to the manufacturer that the product is free of any
substances on the WADA Prohibited List
Ask whether the manufacturer is prepared to stand behind its product
Ask the manufacturer whether any products containing prohibited substances are manufactured at the
same plant as the supplement.
The NSF Certified for Sport program (see Resource Tips) can help athletes identify products that have been
tested to confirm their content and purity.
Creatine is widely used as an ergogenic aid. It is a naturally occurring compound produced by the liver,
kidneys and pancreas from the amino acids glycine, arginine and methionine. Most individuals also
consume 1–2 g exogenous creatine daily, primarily from meat and fish.8
Creatine is promoted as improving muscle strength and outcomes in short-duration anaerobic events.
Studies of its effectiveness are conflicting. It may improve performance in power sports (e.g., weight lifting,
sprinting) but has not demonstrated any benefit in endurance sports (e.g., cycling, cross-country running).8,9
Creatine is taken as a loading dose of 5 g 4 times a day for the first 4–6 days followed by the standard dose
of 2 g daily for the next 3 months.9 Because of the theoretical concerns of dehydration and heat illness
during sporting events, it is recommended that athletes taking creatine drink 6–8 glasses of water per day.9
Side effects of creatine are usually minimal and include nausea, vomiting, diarrhea, muscle cramps and
weight gain (the latter is thought to be due to water retention). The greatest safety concern with long-term
use of creatine is its potential effect on renal function.8,9,21 Several case reports describe compromised
renal function with the use of creatine.9
Androstenedione is a precursor of testosterone and estrone. There is some evidence that it may elevate
testosterone levels and increase strength and muscle mass during resistance training.8 Information on the
side effects of long-term use is not available but these are expected to be similar to those of anabolic
steroids.8 Though it is illegal in Canada, some athletes may obtain supplies from sources in the United
States or online.
Prohibited Substances/Therapeutic Use Exemptions

Athletes are not permitted to use prohibited substances because they are believed to enhance performance.
If a prohibited substance or method is used by the athlete for a specified, legitimate medical condition, they
must apply for a Therapeutic Use Exemption. Some substances are not prohibited but the athlete must
submit a Declaration of Use when taking them for medical reasons. Table 3 lists categories of drugs that
may be considered prohibited substances in amateur sports.
The list of prohibited substances may vary among different sport organizations and is subject to change.
The World Anti-Doping Agency (WADA) annually publishes the WADA Prohibited List which is the
international standard that designates what substance and method is prohibited in and out of competition. It
also indicates whether a substance is prohibited only in a particular sport. Other substances are included in
the WADA Monitoring Program; these are not prohibited but WADA monitors their use to detect potential
patterns of misuse by athletes. These lists can be accessed through the CCES website (see Resource Tips).
19
Table 3: Substances Prohibited in Amateur Sports
Prohibited Examples Comments
Anabolic androgenic androstenedione Prohibited at all times
steroids and other anabolic dehydroepiandrosterone Clenbuterol (a beta2-agonist) is included
agents
fluoxymesterone as an anabolic agent.
nandrolone
stanozolol
testosterone
Beta1-adrenergic acebutolol Prohibited during competition in certain

antagonists atenolol sports, e.g., billiards, darts, golf. Archery
and shooting prohibit beta-blocker use
metoprolol both during and outside competition.
propranolol
Beta2-agonists formoterol When given orally or by injection, beta2-

salbutamol agonists may have anabolic effects.
salmeterol Therapeutic doses of formoterol,

salbutamol and salmeterol by inhalation
terbutaline are not prohibited.
Terbutaline by inhalation requires a
Therapeutic Use Exemption.
Caffeine Not on the Prohibited List but included

in the Monitoring Program since 2004.
Diuretics and masking acetazolamide Prohibited because they are used to

agents desmopressin promote urinary excretion of a
prohibited substance.
furosemide
Exception: pamabrom and topical
hydrochlorothiazide dorzolamide and brinzolamide.
probenecid
spironolactone
triamterene
Glucocorticoids fluticasone Prohibited when administered by oral, iv,

hydrocortisone im or rectal routes. Glucocorticoids
administered by iv injection, im injection,
methylprednisolone oral or rectal routes require a
prednisone Therapeutic Use Exemption.
Prohibited Examples Comments
Hormone and metabolic anastrozole Prohibited at all times. Insulin is
modulators clomiphene permitted only to treat athletes with
certified insulin-dependent diabetes. A
exemestane Therapeutic Use Exemption form must
fulvestrant be completed.
insulin
letrozole
raloxifene
tamoxifen
Opioids fentanyl Some opioids and derivatives such as

hydromorphone codeine, dextromethorphan,
diphenoxylate and propoxyphene are
meperidine permitted. Hydrocodone and tramadol
morphine are included in the Monitoring Program
(2012).
oxycodone
Peptide hormones, growth chorionic gonadotropin

factors and related (HCG)
substances luteinizing hormone (LH)
in males
erythropoietin
growth hormone and
other growth factors
Stimulants ephedrinea Oral decongestants containing

phenylephrine are included in the
fenfluramine Monitoring Program. Use of
methylhexaneamine decongestant nasal sprays is permitted.
(dimethylamylamine,
DMAA)
methylphenidate
modafinil
phentermine
pseudoephedrinea
a Ephedrine (>10 µg/mL urinary level) and pseudoephedrine (>150 µg/mL urinary level) are prohibited in competition;
lesser amounts are permitted but are included in the World Anti-Doping Agency (WADA) 2015 Monitoring Program.
Although the urinary threshold should not be attained with therapeutic use of pseudoephedrine, WADA suggests
discontinuing the drug 24 hours before competition.22
Resource Tips
Canadian Centre for Ethics in Sport (CCES). Available from: www.cces.ca. By phone: 613-521-3340 or 1-800-
672-7775. By email: [email protected].
Global Drug Reference Online (Global DRO). Available from: www.globaldro.com/Home.
NSF International Certified for Sport. Available from: www.nsfsport.com.
World Anti-Doping Agency (WADA). Available from: wada-ama.org. By phone: 514-904-9232.

Low Back Pain
Kelly Grindrod, BSc(Pharm), PharmD, MSc

Jason Kielly, BSc(Pharm), PharmD
Carlo Marra, BSc(Pharm), PharmD, PhD, FCSHP
Pathophysiology
Low back pain is defined as spinal and paraspinal symptoms in the lumbosacral region that can extend to the gluteal muscles,
hips and lower extremities.1,2 With an estimated prevalence of 15–30%, between 50% and 80% of people will experience an
episode of low back pain during their lifetime.3 Globally, low back pain causes more disability than any other disease.4 This
results in significant direct and indirect costs to the healthcare system including direct medical care, disability, decreased
productivity while at work and time lost from work.5
Despite the high prevalence of disease, the incidence and prognosis of low back pain are difficult to characterize because of the
variety of ways low back pain has been defined in studies.6 Historically, there has been a widely held belief that up to 90% of
cases of low back pain will resolve within 2 months. Newer data indicate rapid improvement occurs within 6 weeks of
presentation, after which the rate of improvement is slower.7 Up to 75% of people with low back pain will continue to have some
degree of pain after 1 year.6,7 Most will experience relapses in symptoms, and up to 10% of individuals experience chronic
symptoms resulting in significant time away from work.6,8,9,10
Factors that increase the risk of low back pain include age (most common between 45 and 64 years), greater height, climbing
stairs often and stress.11 In addition, individuals who develop low back pain have a poorer prognosis if they have a higher level
of disability, have sciatica, are older or are in poor general health, have more stress in their lives, have poor relationships with
work colleagues or have a heavy physical demand at work.8,9,10 Other factors that may be associated with low back pain
include obesity12 and smoking.13 Usual daily activities that include frequent walking, standing, lifting or carrying have been
associated with low back pain; however, evidence indicates these activities are not causative on their own.14,15,16
Low back pain can be acute (<4 weeks' duration), subacute (4–12 weeks' duration) or chronic (>12 weeks' duration). Low back
pain can be categorized as: 1) nonspecific low back pain; 2) low back pain associated with radiculopathy or spinal stenosis; or
3) low back pain associated with other specific spinal causes.2
In over 85% of people, the cause of low back pain cannot be reliably identified, though muscular-ligamentous injuries of the low
back such as strains and sprains are often suspected.17 The symptoms, similar to those experienced with other muscle,
ligament and tendon disorders, include localized pain of varying severity, spasm, inflammation and immobility.
Radiculopathy results from the dysfunction of the nerve root.18 Symptoms include pain, sensory impairment, weakness and
impaired tendon reflexes. Sciatica, which is the most common type of radiculopathy, is characterized by pain that radiates to
the buttocks and down the posterior-lateral aspect of the leg. It may be described as a “shooting pain” originating in the lumbar
region (location of the sciatic nerve).
Other specific spinal causes can include cancer, vertebral compression fractures, spinal infections (e.g., herpes zoster), disc
herniation, inflammatory arthritis (e.g., ankylosing spondylitis) and referred visceral pain (e.g., prostatitis, endometriosis,
abdominal aortic aneurysm).2
Goals of Therapy
Relieve symptoms
Maintain or improve mobility and quality of life
Prevent or minimize re-injury
Healthcare practitioners can support the goals of therapy by educating patients and caregivers to help them understand the
condition and make informed therapy decisions. Evidence suggests that patient education by primary care providers may
reduce the number of primary care visits related to low back pain and provide long-term reassurance for patients with low back
pain.19
Patient Assessment
An algorithm for assessing patients with low back pain is presented in Figure 1.
The most important aspect of assessing low back pain is ruling out potential serious etiologies that require immediate
evaluation by an appropriate healthcare practitioner, including those patients who have experienced a recent trauma, rapid
weight loss or fever or those with increasing motor weakness (see Figure 1 for a more complete list). Patients with chronic pain
(lasting >12 weeks), sciatic conditions or specific causes for their pain also require further evaluation.
Principles of Therapy
Current pharmacologic therapies for low back pain provide symptomatic relief but are not curative. Therefore, the choice of
agent is based on a combination of risk vs. benefit, cost and patient preference. Pharmacologic therapy should always be
initiated in combination with nonpharmacologic modalities. If tolerated, pharmacologic therapies should be tried for at least 2–
4 weeks to allow the patient to fully assess effectiveness.
Numerous treatment approaches are supported by various levels of evidence of efficacy in the management of low back pain
(see Table 1). Much of the available evidence lacks rigor with respect to study methodologies including sample size,
randomization, use of placebo, blinding, controlling for confounding variables and population variances (acute, chronic,
±sciatica). Many guidelines are not developed in a systematic, scientifically rigorous manner, do not consider patient
preferences, have no established process for updating, and lack overall transparency.20,21 Nonetheless, systematic reviews,
including several by the Cochrane Back Pain group, (see Suggested Readings) and improved evidence-based guidelines are now
available to guide the treatment of low back pain.2,21,22,23,24,25
a
Table 1: Conservative Treatments for Low Back Pain
Subacute or
Chronic (>4
Category Treatment Acute (<4 wk) wk)
Pharmacologic Therapy Acetaminophen ■ ■
NSAIDs ■ ■
Benzodiazepines, muscle relaxants ■
Antidepressants (tricyclic) ■
Opioids, tramadol ■ ■
Nonpharmacologic Therapy Self-care: Advice to remain active ■ ■
Self-care: Books, handouts ■ ■
Self-care: Application of superficial heat ■
Exercise ■
Massage ■
Acupuncture ■
Yoga ■
Cognitive-behavioural therapy ■
Progressive relaxation ■
Intensive interdisciplinary rehabilitation ■
a
Interventions supported by fair-quality evidence of moderate benefit, or small benefit but no significant harms, costs or burdens.
Adapted with permission from Chou R, Qaseem A, Snow V et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American
College of Physicians and the American Pain Society. Ann Intern Med 2007;147:478-91. Copyright © 2007 American College of Physicians. All Rights Reserved.
Reprinted with the permission of American College of Physicians, Inc.
In nonspecific low back pain, the primary recommendation is to provide patients with information on treatment options and the
expected course of disease, and to advise them to maintain usual activity. Advise individuals with low back pain to stay active
and only avoid activities that may worsen pain or injury (e.g., heavy lifting, twisting, high impact exercise). Although bed rest
was historically recommended, staying active may offer patients better pain relief and function.26 If possible, patients should be
assessed by a physiotherapist to identify appropriate exercise intensity.27
Other nonpharmacologic therapies such as back exercises and spinal manipulation have not been shown to improve pain or
function in acute nonspecific low back pain but may provide some relief in patients with chronic symptoms.23,28 Consistent
evidence shows that acupuncture and massage are both safe and effective in alleviating some of the symptoms of chronic low
back pain.29 Yoga, pilates and stretching may improve both pain and function in chronic low back pain.30,31,32,33,34,35 In chronic
nonspecific low back pain, exercise programs are at least as effective as other conservative treatments such as the provision of
self-care education books, massage, spinal manipulation and back schools (structured programs where individuals are taught
how to maximize recovery and minimize recurrences of low back pain).36,37,38 Certain post-treatment exercise programs may
prevent the recurrence of low back pain.39
The application of heat may provide short-term relief in acute pain but there is insufficient evidence to recommend the use of
cold packs.40 Other modalities such as therapeutic ultrasound,41 lumbar supports, corsets, shoe lifts, insoles and orthoses42
have shown little benefit.
Surgical therapy is considered in individuals with persistent and disabling symptoms from common degenerative spinal
changes or spinal stenosis, or in individuals with disabling radiculopathy from a herniated disk.43
Behavioural therapy may provide some short-term pain relief in chronic low back pain but does not offer long-term
improvements compared with usual care.44 There is no demonstrated benefit of behavioural therapy when compared to other
forms of therapy; however, the combination of behavioural therapy and exercise may decrease disability and pain and improve
quality of life compared with exercise alone.45 A Cochrane systematic review suggests that a multidisciplinary biopsychosocial
treatment approach may result in larger improvements in pain and daily function compared with usual care or interventions
aimed only at physical factors.46 Due to the need for stronger evidence, behavioural therapy for chronic low back pain should be
incorporated on an individual basis and under the care of a qualified professional.
Encourage patients to remain active; physical therapy exercises and spinal manipulation should be reserved for individuals who
fail to improve after an acute episode (>4 weeks).2
For further discussion of pharmacologic therapy for low back pain, consult the Compendium of Therapeutic Choices: Low Back
Pain.
Products: Internal Analgesics and Antipyretics; Herbal and Natural Health Products: Single Entity.
Medication is commonly prescribed for nonspecific low back pain but is primarily intended to relieve pain and discomfort in the
short term and to facilitate activity. Long-term therapy may be required in individuals who experience chronic back pain.
Common treatments for nonspecific low back pain include acetaminophen, NSAIDs, opioid analgesics, skeletal muscle
relaxants and antidepressants. Evidence of efficacy for all agents is generally weak.24 Table 3 presents selected pharmacologic
options for the treatment of low back pain.
Acetaminophen has long been the first-line agent to treat low back pain, but its efficacy is in question.50,51 Small trials have
suggested that acetaminophen does not provide superior pain relief compared with NSAIDs.52,53 A small randomized
controlled trial found that continuous heat wrap therapy may provide better pain relief than regular doses of acetaminophen or
ibuprofen.54 However, acetaminophen has a better safety profile than NSAIDs, so it continues to be recommended as the first-
line pharmacologic option for alleviating symptoms associated with back pain.2
NSAIDs may provide small improvements in low back pain in patients without sciatica compared with placebo. There is no
demonstrated superiority of one NSAID over another.52
Combination products containing acetaminophen, caffeine and codeine (8 mg) are options for nonresponsive individuals in the
short-term but they have not demonstrated benefit in the management of acute or chronic nonspecific low back pain.
In low back pain, as with other muscular strain disorders, the complexity of spasm physiology makes it difficult to determine the
extent to which spasm is contributing to the injury or symptoms. Muscle relaxants such as methocarbamol are really sedatives
with very little direct muscle-relaxing properties. Despite their popularity, these agents have not been shown to provide relief in
low back pain.55
Small trials comparing opioid analgesics with NSAIDs report conflicting results; opioids may be reserved for individuals who do
not respond to acetaminophen or NSAIDs.24,52 A systematic review suggests there is insufficient evidence to determine the
effectiveness of long-term opioid therapy in improving chronic pain and function.56 There is evidence of short-term efficacy
(moderate for pain and small for function) of opioids to treat chronic low back pain compared with placebo. However, the
effectiveness and safety of long-term opioid therapy for treatment of chronic low back pain remains unproven.57 A systematic
review of opioids in chronic low back pain showed tramadol had a small effect on pain but was also associated with significant
side effects such as headache, nausea, somnolence and constipation.58 Tramadol is not routinely used to treat low back pain
as adverse effects limit its use in many patients.
If patients have contraindications to analgesics, have failed all other treatments or have been diagnosed with a spastic
component to their disease, direct-acting muscle relaxants (baclofen, benzodiazepines, cyclobenzaprine and tizanidine) may
be used. While these agents are generally not recommended for the management of acute or chronic low back pain, evidence
suggests that they are more effective than placebo and may result in additive benefit when used in combination with other
agents.55 However, the side effect profile and potential for long-term abuse render these agents undesirable.
There have been numerous claims that agents such as D-phenylalanine, devil's claw, capsicum, ginger, turmeric and white
willow bark are effective in managing symptoms of low back pain. A Cochrane review of natural health products for
nonspecific low back pain found that low to moderate quality evidence suggests that four herbal medicines (i.e., devil’s claw,
white willow bark, cayenne and comfrey root extract) may reduce pain in acute and chronic lower back pain.59 For devil's
claw, standardized daily doses of 50–100 mg of the active ingredient harpagoside improved pain compared with placebo.
White willow bark, in standardized daily doses of 120–240 mg of the active ingredient salicin has provided similar benefit.
Topically applied cayenne and comfrey appear to reduce pain more than placebo. These topical agents could be considered
as a treatment option for acute (comfrey) and for chronic (cayenne) low back pain. There is no evidence that any of these
substances are safe or efficacious for long-term use.59
Note that the quantity of active ingredient was standardized for these studies and this cannot be expected with all products
currently available in Canada.
Table 2 provides a monitoring plan for patients with low back pain.
Table 2: Monitoring of Therapy for Low Back Pain

Parameter Degree Timeframe Action/Comments
Pain relief Elimination of Patient or caregiver: Patient requires further assessment by
pain or Assess daily appropriate healthcare practitioner if symptoms
progression Healthcare practitioner: not relieved after adequate trial of at least 2
toward Call on day 3, 7, 14 and 28 analgesics or if new or worsening pain symptoms
predefined goals develop during therapy.
as set by patient Use visual analog scale or other individual
at the beginning measure (e.g., ability to perform ADLs—
of therapy walking, gardening) to quantify and
characterize pain.
Trial of each analgesic for 2–4 wk at optimal
dose to fully assess impact on daily
activities/functioning.
Considerations in timing of medications:
Around-the-clock vs. PRN
Take dose of analgesic at least 1 h prior
to activities that may exacerbate pain.
Nausea, Minimal or none Patient or caregiver: Change therapy if symptoms severe or intolerable.
dyspepsia, during therapy Monitor daily Minimize development by taking medication with
abdominal Healthcare practitioner: food or milk.
discomfort Call on day 3 and 7 Consider antacids or H2RAs to treat dyspepsia.
(NSAIDs)
Hematemesis, None during Patient or caregiver: Assess risk of GI complications (see
melena, therapy Monitor daily on an Osteoarthritis, Table 3 for risk factors of serious
hematochezia ongoing basis adverse effects with NSAID therapy). If high risk,
(NSAIDs) Healthcare practitioner: patient requires further assessment by appropriate
Call on days 3, 7 and 28, healthcare practitioner. Patient should discontinue
then ask when medication therapy immediately and seek medical attention if
is refilled these signs or symptoms develop.
Hypertension Stable during Healthcare practitioner: Monitor patients with pre-existing hypertension; if
(NSAIDs) therapy Measure BP within 1 wk of BP increases, adjust the dose of the NSAID or that
starting NSAIDs of the antihypertensive.
Renal function No significant Patient or caregiver: Look Assess risk of renal complications (see
and signs of change in renal for decreased urine Osteoarthritis, Table 3 for risk factors of serious
fluid retention function production; watch for adverse effects with NSAID therapy). Hold NSAID
(weight gain signs of fluid retention on that day if patient cannot eat or drink.
or edema) in an ongoing basis, (e.g., Discontinue NSAID if significant changes in serum
high-risk edema). Patients with creatinine, electrolytes or signs of fluid retention
patients severe heart failure should occur.
(NSAIDs) weigh themselves daily.
Healthcare practitioner: In
patients >65 y or with
other risk factors, consider
baseline serum creatinine,
repeat at 1 wk and then
periodically afterwards.
Recurrent low Avoid or Patient: Ongoing Patient to seek medical attention if recurrent
back injury minimize episodes occur, to identify and implement
potential nonpharmacologic strategies for
management and prevention.
Functional Avoid Patient: Daily Further assessment by appropriate healthcare

ability after immobilization. Healthcare practitioner: practitioner required if unable to perform ADL.
acute injury Patient able to Call on day 3 and 7
perform ADLs,
usual activity to
tolerable pain
level
Abbreviations: ADL = activities of daily living; BP = blood pressure; H2RA = H2-receptor antagonist

Advise patients on:
The importance of using nonpharmacologic measures concurrently with medication

The importance of maintaining ordinary activities and increasing level of activity based on pain tolerance
Expected benefits of treatment
Possible side effects (Table 3) and their management
When to contact a healthcare practitioner.
Resource Tips
For more information on low back pain, contact: Chronic Pain Association of Canada, P.O. Box 66017 Heritage Postal Station,
Edmonton, AB, T6J 6T4. Available from: www.chronicpaincanada.com.
Algorithms
1,2
Figure 1: Assessment of Patients with Low Back Pain
a
Cauda equina syndrome: a rare clinical syndrome characterized by dull pain in the lower back and upper buttock region, analgesia in
the buttocks, genitalia or thigh, accompanied by a disturbance of bowel and bladder function.
b History of depression, psychological distress or substance abuse can increase likelihood of persistent back pain.
c Sharp/burning pain radiating down posterior-lateral aspect of one or both legs. Symptoms worsen with change of position.
Drug Table
Table 3: Drug Therapy for Low Back Pain2,47

Interactions
Drug Class: Analgesics, oral

Interactions
acetaminophen 325–1000 mg Q4–6H po Hepatotoxicity: Acetaminophen Maximal onset

Atasol Preparations, Tylenol, SR: 650 mg Q8H po (maximum Increased risk in has been of pain relief
generics 4 g/day) malnourished reported to within 24–48 h.
patients, those increase INR in Lower doses
$ with excessive warfarin-treated may be required
alcohol intake patients.48 Check in patients with
(e.g., >3 drinks INR if severe hepatic
per day) or pre- acetaminophen and renal
existing hepatic ≥2 g/day is used disease.
disease; perform for ≥3
baseline LFTs in Caution with
consecutive days.
high-risk concurrent use
Adjust warfarin
patients. of other
dosage as
products
required.
containing
Phenytoin, acetaminophen
barbiturates, (do not exceed
carbamazepine 4 g/day).
may increase
Consider regular
acetaminophen
schedule in
metabolism and
individuals with
formation of toxic
pain persisting
metabolite, thus
throughout the
increased risk of
day. PRN dosing
hepatotoxicity;
is acceptable
risk may be
for episodic
increased in
pain of short
patients taking
duration.
high therapeutic
doses of
acetaminophen
and antiepileptic
drugs chronically.
Interactions
acetaminophen/caffeine/codeine 1–2 tablets Q4–6H po Hepatotoxicity: Acetaminophen Maximal onset

8 mg (maximum 4 g/day Increased risk in has been of pain relief
Atasol with Codeine, generics acetaminophen) malnourished reported to within 24–48 h.
patients, those increase INR in Lower doses
$ with excessive warfarin-treated may be required
alcohol intake patients.48 Check in patients with
(e.g., >3 drinks INR if severe hepatic
per day) or pre- acetaminophen and renal
existing hepatic ≥2 g/day is used disease.
disease; perform for ≥3
baseline LFTs in Caution with
consecutive days.
high-risk concurrent use
Adjust warfarin
patients. of other
dosage as
Sedation, products
required.
nausea, vomiting, containing
constipation. Phenytoin, acetaminophen
may increase
Consider regular
acetaminophen
schedule in
metabolism and
individuals with
formation of toxic
pain persisting
metabolite, thus
throughout the
increased risk of
day. PRN dosing
hepatotoxicity;
is acceptable
risk may be
for episodic
increased in
pain of short
patients taking
duration.
high therapeutic
doses of Recommended
acetaminophen for short-term
and antiepileptic use, e.g., 2–3
drugs chronically. days.
Increased Elderly are at
adverse effects higher risk for
with concurrent adverse effects.
use of other
sedating or
constipating
medications.
Drug Class: NSAIDs, oral

Interactions
ibuprofen 200–400 mg Q6–8H po; GI: Dyspepsia, Warfarin: Caution when

Advil, Advil Liqui-Gels, Motrin, maximum dose for self-care epigastric pain, Increased used in elderly
Motrin IB, generics 1200 mg/day nausea/vomiting, bleeding risk via or patients with
diarrhea, gastric antiplatelet pre-existing
$ and duodenal effects and GI renal disease or
ulcers, GI complications; comorbid
bleeding. monitor INR more conditions that
Cardiovascular: frequently during may affect renal
MI, stroke, heart initial period after function (e.g.,
failure, fluid NSAID started HF, diabetes,
retention, and monitor for hypertension).
hypertension. signs of bleeding. Advise patients
Increased lithium to stop taking
Nephrotoxicity levels—monitor.
may occur; avoid NSAID that day
NSAIDs in NSAIDs inhibit if unable to eat
patients with the renal or drink.
severe renal elimination of NSAIDs are not
impairment (ClCr methotrexate. a substitute for
<30 mL/min). Avoid NSAIDs in ASA being taken
people using for MI or stroke
CNS: Dizziness, high-dose
drowsiness, prophylaxis.
methotrexate
headache, (e.g., cancer Avoid in patients
tinnitus, treatment). For with ASA or
confusion people using ibuprofen
(especially in the intermittent, low- hypersensitivity.
elderly); CNS dose Avoid
effects may be methotrexate for concurrent use
dose related and arthritis, risk is of other NSAID-
respond to minimal. containing
decreased Antihypertensives products
dosage. Minor or (e.g., beta- (increased risk
serious skin blockers, of GI-related
rashes, pruritus. diuretics, ACEIs): side effects).
May decrease
PRN dosing is
antihypertensive
acceptable for
effects; measure
episodic pain of
baseline BP,
short duration;
remeasure 1–2
consider regular
wk after starting
schedule if pain
NSAID and adjust
persists
antihypertensive
throughout the
therapy as
day.
required.
Consider
Increased risk of
gastroprotection
GI bleeding with
with
SSRIs.
misoprostol or
Increased risk of PPI in high-risk
GI adverse patients.
effects with
Increased risk of
alcohol.
stroke or
Give 30 min after serious CV
or 8 h before low- events at doses
dose ASA. ≥2400 mg/day.
Doses ≥2400
mg/day should
not be used in
patients with a
history of CV
events or with
risk factors for
CV disease.49
Interactions
naproxen sodium 220–440 mg/day po in 1 or 2 GI: Dyspepsia, Warfarin: Caution when

Aleve, generics divided doses; maximum dose epigastric pain, Increased used in elderly
for self-care 440 mg/day nausea/vomiting, bleeding risk via or patients with
$$ diarrhea, gastric antiplatelet pre-existing
and duodenal effects and GI renal disease or
ulcers, GI complications; comorbid
bleeding. monitor INR more conditions that
Cardiovascular: frequently during may affect renal
MI, stroke, heart initial period after function (e.g.,
failure, fluid NSAID started HF, diabetes,
retention, and monitor for hypertension).
hypertension. signs of bleeding. Advise patients
Increased lithium to stop taking
Nephrotoxicity levels—monitor.
may occur; avoid NSAID that day
NSAIDs in NSAIDs inhibit if unable to eat
patients with the renal or drink.
severe renal elimination of NSAIDs are not
impairment (ClCr methotrexate. a substitute for
<30 mL/min). Avoid NSAIDs in ASA being taken
people using for MI or stroke
CNS: Dizziness, high-dose
drowsiness, prophylaxis.
methotrexate
headache, (e.g., cancer Avoid in patients
tinnitus, treatment). For with ASA or
confusion people using ibuprofen
(especially in the intermittent, low- hypersensitivity.
elderly); CNS dose Avoid
effects may be methotrexate for concurrent use
dose related and arthritis, risk is of other NSAID-
respond to minimal. containing
decreased Antihypertensives products
dosage. Minor or (e.g., beta- (increased risk
serious skin blockers, of GI-related
rashes, pruritus. diuretics, ACEIs): side effects).
May decrease
PRN dosing is
antihypertensive
acceptable for
effects; measure
episodic pain of
baseline BP,
short duration;
remeasure 1–2
consider regular
wk after starting
schedule if pain
NSAID and adjust
persists
antihypertensive
throughout the
therapy as
day.
required.
Consider
Increased risk of
gastroprotection
GI bleeding with
with
SSRIs.
misoprostol or
Increased risk of PPI in high-risk
GI adverse patients.
effects with
alcohol.
Give 30 min after
or 8 h before low-
dose ASA.
Drug Class: Skeletal Muscle Relaxants

Interactions
chlorzoxazone 250–750 mg (chlorzoxazone) Sedation, Increased effects Onset of action

Acetazone Forte TID–QID po dizziness, light- with other CNS within 12–24 h.
Consult and follow directions on headedness, sedating No muscle
$$$ nausea. medications,
combination product labels relaxant has
Hepatotoxicity anticholinergics. demonstrated
has been superior
reported. efficacy.
Use is generally
not
recommended
due to side
effect profile.
Should be used
only in the short
term (2–3
days). Elderly
are at increased
risk of adverse
effects.
Available only in
combination
with
acetaminophen
(with or without
codeine).
methocarbamol 400–1500 mg (methocarbamol) Sedation, Increased effects Onset of action

Robaxin, generics Combination QID po dizziness, light- with other CNS within 12–24 h.
Products: Robax Platinum, Consult and follow directions on headedness, sedating No muscle
Robaxacet, Robaxisal, generics combination product labels nausea. medications, relaxant has
anticholinergics. demonstrated
$$$
superior
efficacy.
Use is generally
not
recommended
due to side
effect profile.
Should be used
only in the short
term (2–3
days). Elderly
are at increased
risk of adverse
effects.
Available as
single entity or
in combination
with ASA or
acetaminophen
(with or without
codeine) or
ibuprofen.
Interactions
orphenadrine 50–100 mg BID–TID po Sedation, Increased effects Onset of action

Orfenace, generics dizziness, light- with other CNS >24 h.
headedness, sedating No muscle
$$$$ nausea. medications, relaxant has
Anticholinergic anticholinergics. demonstrated
effects: superior
Agitation, dry efficacy.
mouth,
constipation, Use is generally
hallucinations, not
urinary retention, recommended
blurred vision. due to side
Contraindicated effect profile.
with BPH, angle Should be used
closure only in the short
glaucoma, term (2–3
bladder days). Elderly
obstruction, are at increased
stenosing peptic risk of adverse
ulcer, myasthenia effects.
gravis.
devil's claw (harpagophytum 50–100 mg (harpagoside) per Diarrhea, GI Theoretical Lack of product
procumbens) day po upset. interaction with standardization
many drugs due may result in
$$ to possible inter- and intra-
inhibition of product
CYP2C9, 2C19 or variability.
3A4. May
enhance
anticoagulant
effect of warfarin
(bruising reported
with
combination).
Interactions
white willow bark (salix alba) 120–240 mg (salicin) per day po Minimal adverse Theoretical drug Onset of action
effects reported interaction with 1–3 wk.
$$ with oral use. tannin-containing Has been
One case of herbs. studied in
hypersensitivity Significance of chronic low
reported. other interactions back pain only.
Theoretical (but unknown due to Exact
unproven) risks lack of mechanism of
associated with information action unknown,
tannins include pertaining to the but may
kidney and liver exact salicylate possess anti-
damage, GI content. inflammatory
intolerance. activity. Long-
term efficacy
and toxicity are
unknown.
Lack of product
standardization
may result in
inter- and intra-
product
variability.
Constituents
include tannins,
flavonoids and
salicylates
(metabolite).
Avoid in patients
with history of
salicylate
hypersensitivity.
a
Cost of 30-day supply, includes drug cost only.
Abbreviations: ACEI = angiotensin converting enzyme inhibitor; BP = blood pressure; BPH = benign prostatic hyperplasia; CV
= cardiovascular; HF = heart failure; INR = international normalized ratio; LFT = liver function tests; PPI = proton pump inhibitor
Legend: $ <$5 $$ $5–10 $$$ $10–20 $$$$ $20–30
Suggested Readings
Chou R. In the clinic. Low back pain. Ann Intern Med 2014;160:ITC6-1.
Chou R, Qaseem A, Snow V et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American
College of Physicians and the American Pain Society. Ann Intern Med 2007;147:478-91.
Cochrane Library. Cochrane Back Group. Available from:

onlinelibrary.wiley.com/book/10.1002/14651858/homepage/crg_BACK.html#BACK.
Cohen SP, Argoff CE, Carragee EJ. Management of low back pain. BMJ 2008;337:a2718.
References
1. Cohen SP, Argoff CE, Carragee EJ. Management of low back pain. BMJ 2008;337:a2718.
2. Chou R, Qaseem A, Snow V et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the
American College of Physicians and the American Pain Society. Ann Intern Med 2007;147:478-91.
3. Andersson GB. Epidemiological features of chronic low-back pain. Lancet 1999;354:581-5.
4. Hoy D, March L, Brooks P et al. The global burden of low back pain: estimates from the Global Burden of Disease 2010
study. Ann Rheum Dis 2014;73:968-74.
37. Rubinstein SM, Terwee CB, Assendelft WJ et al. Spinal manipulative therapy for acute low-back pain. Cochrane Database
Syst Rev 2012;9:CD008880.
38. Heymans MW, van Tulder MW, Esmail R et al. Back schools for non-specific low-back pain. Cochrane Database Syst Rev
2004;4:CD000261.
39. Choi BK, Verbeek JH, Tam WW et al. Exercises for prevention of recurrences of low-back pain. Cochrane Database Syst
Rev 2010;1:CD006555.
40. French SD, Cameron M, Walker BF et al. Superficial heat or cold for low back pain. Cochrane Database Syst Rev
2006;1:CD004750.
41. Ebadi S, Henschke N, Nakhostin Ansari N et al. Therapeutic ultrasound for chronic low-back pain. Cochrane Database
Syst Rev 2014;3:CD009169.
42. Chuter V, Spink M, Searle A et al. The effectiveness of shoe insoles for the prevention and treatment of low back pain: a
systematic review and meta-analysis of randomised controlled trials. BMC Musculoskelet Disord 2014;15:140.
43. Chou R, Loeser JD, Owens DK et al. Interventional therapies, surgery and interdisciplinary rehabilitation for low back
pain: an evidence-based clinical practice guideline from the American Pain Society. Spine (Phila Pa 1976) 2009;34:1066-
77.
44. Henschke N, Ostelo RW, van Tulder MW et al. Behavioural treatment for chronic low-back pain. Cochrane Database Syst
Rev 2010;7:CD002014.
45. Monticone M, Ferrante S, Rocca B et al. Effect of a long-lasting multidisciplinary program on disability and fear-
avoidance behaviors in patients with chronic low back pain: results of a randomized controlled trial. Clin J Pain
2013;29:929-38.
46. Kamper SJ, Apeldoorn AT, Chiarotto A et al. Multidisciplinary biopsychosocial rehabilitation for chronic low back pain.
47. McEvoy GK, Snow EK, Miller J et al., eds. AHFS drug information. Bethesda: American Society of Health-System
Pharmacists; 2016.
48. Lopes RD, Horowitz JD, Garcia DA et al. Warfarin and acetaminophen interaction: a summary of the evidence and
biologic plausibility. Blood 2011;118:6269-73.
49. Government of Canada. Healthy Canadians. New safety information for prescription-strength ibuprofen: Risk of heart
attack and stroke at high doses. Available from: www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-
sc/2015/53055a-eng.php.
50. Machado GC, Maher CG, Ferreira PH et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis:
systematic review and meta-analysis of randomised placebo controlled trials. BMJ 2015;350:h1225.
51. Williams CM, Maher CG, Latimer J et al. Efficacy of paracetamol for acute low-back pain: a double-blind, randomised
controlled trial. Lancet 2014;384:1586-96.
52. Roelofs PD, Deyo RA, Koes BW et al. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst
Rev 2008;1:CD000396.
53. Davies RA, Maher CG, Hancock MJ. A systematic review of paracetamol for non-specific low back pain. Eur Spine J
2008;17:1423-30.
54. Nadler SF, Steiner DJ, Erasala GN et al. Continuous low-level heat wrap therapy provides more efficacy than ibuprofen
and acetaminophen for acute low back pain. Spine (Phila Pa 1976) 2002;27:1012-7.
55. van Tulder MW, Touray T, Furlan AD et al. Muscle relaxants for non-specific low back pain. Cochrane Database Syst Rev
2003;4:CD004252.
56. Chou R, Turner JA, Devine EB et al. The effectiveness and risks of long-term opioid therapy for chronic pain: a
systematic review for a National Institutes of Health Pathways to Prevention Workshop. Ann Intern Med 2015;162:276-
86.
57. Chaparro LE, Furlan AD, Deshpande A et al. Opioids compared with placebo or other treatments for chronic low back
pain: an update of the Cochrane Review. Spine (Phila Pa 1976) 2014;39:556-63.
58. Deshpande A, Furlan A, Mailis-Gagnon A et al. Opioids for chronic low-back pain. Cochrane Database Syst Rev
2007;3:CD004959.
59. Oltean H, Robbins C, van Tulder MW et al. Herbal medicine for low-back pain. Cochrane Database Syst Rev
2014;12:CD004504.

Low Back Pain
CPhA assumes no responsibility for or liability in connection with the use of this information. For clinical use only and not intended for for use by patients. Once printed there is
no quarantee the information is up-to-date. [Printed on: 09-08-2017 09:49 AM]
Osteoarthritis
Kelly Grindrod, BSc(Pharm), PharmD, MSc

Jason Kielly, BSc(Pharm), PharmD
Carlo Marra, BSc(Pharm), PharmD, PhD, FCSHP
Pathophysiology
Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 1 in 10 Canadians.1 The
Global Burden of Disease 2010 study found that knee and hip OA ranked as the eleventh highest contributors to
global disability.2 OA is a progressive disease of the synovial joints. In the past, OA was thought to be due to
daily “wear and tear” that resulted from excessive and repetitive force on the cartilage in joints. While this is
partially true, OA is now thought to be a systemic disorder due to an imbalance between joint destruction and
repair.3,4,5 This ultimately results in a breakdown of cartilage and bone, leading to symptoms of pain, stiffness
and functional disability.5 OA is more prevalent as we age, affecting nearly half the population over age 70.6
Synovial joints are structures in which the opposing bony surfaces are covered with a layer of cartilage. There
is also a joint cavity that contains synovial fluid and is lined with synovial membrane.3 Cartilage acts as a shock
absorber and, with synovial fluid, provides a smooth, low-friction surface for movement. Surrounding the joints
are the articular capsule, ligaments, muscles and tendons, all of which act to stabilize and protect the joint.
In early disease, the joint maintains function by thickening the cartilage. As the disease progresses, the
cartilage softens, becoming pitted and frayed, and pieces may break off into the synovial fluid. This causes
further damage and interferes with joint function. The joint may also lose its shape, and the surrounding
ligaments, muscles and tendons may start to weaken.
As the cartilage deteriorates, the joint space narrows and the bones start to rub against one another. At this
point, the bones may start to remodel, leading to a thickening of the bone ends and the formation of bony
outgrowths (osteophytes) and subchondral cysts. These changes may lead to joint deformities. Generally, OA is
not associated with inflammation but symptomatic inflammation of the synovial lining and/or joint may occur
in severe OA.
The most significant risk factors for OA are advancing age and female gender.6,7 Other risk factors include
obesity,8 quadriceps muscle weakness,9 family history,10,11 joint injury,12,13,14 and joint overuse or injury
associated with certain sports (e.g., soccer)15 and occupations (e.g., farming).16
Goals of Therapy
Relieve symptoms such as pain and inflammation
Maintain or improve mobility and quality of life
Minimize functional disability and improve physical functioning
Healthcare practitioners can educate patients and caregivers to help them understand the condition and make
informed decisions about which therapies to choose.
Patient Assessment
Typically, OA occurs in the hands, knees, hips, feet, neck and back (from most to least common).17
Asymmetrical joint pain is the most common symptom of OA.18,19 The synovial joints are generally insensitive
to pain but can become sensitized in OA as a result of physiologic stress and damage to tissue and nerves.
Pain does not arise from the damaged cartilage itself but is caused by the various stresses placed on the
muscles, ligaments and tendons in the areas surrounding the cartilage as a result of the damage. The pain is
usually felt near the joint during use but it may be referred elsewhere and may be felt at night or during rest with
more severe disease.20,21 Stiffness after inactivity and limited range of motion are other common symptoms.
Inflammation may or may not be present. Crepitus may be present with joint movement. Table 1 lists the signs
and symptoms of OA.
19
Table 1: Clinical Features of Osteoarthritis vs. Rheumatoid Arthritis
Clinical
Parameter Feature Osteoarthritis Rheumatoid Arthritis
Symptoms Stiffness Morning or after periods of Significant, prolonged

inactivity; usually lasts (>60 min) in the morning
<30 min
Symptoms Yes—limited to affected No

localized joints
Pain Worsens with activity or Worsens after prolonged

after prolonged use inactivity; usually
(especially with weight- improves with activity
bearing activity)
Signs Symmetry Occasional Common
Tenderness Unusual Over entire exposed joint

spaces
Inflammation Unusual Common
Instability Occasional; buckling or Uncommon

joint instability can result
in decreased range of
movement and falls
Multisystem No Often feel systemically

disease unwell (e.g., can have one
or more of fatigue, fever,
chills, weight loss, hair
loss, dry mouth or dry
eyes)
Rheumatoid arthritis is a systemic inflammatory disease that often presents with joint pain as one of many
symptoms. The scope of this chapter does not include the management of rheumatoid arthritis; however,
symptom recognition (Table 1) is important so that patients with suspected rheumatoid arthritis can be
appropriately evaluated and treated to control inflammation and delay disease progression.
For more information on the management of rheumatoid arthritis, consult the Compendium of Therapeutic
Choices: Rheumatoid Arthritis.
Since joint pain can have a number of causes, it is important to rule out more serious conditions requiring
medical intervention. In particular, recent history of significant trauma, hot, swollen joints, rapidly worsening
pain, joint locking and signs and symptoms of infection should be promptly investigated.19 Reports of
arthralgia have occurred with numerous drugs; however, the numbers are small and often a cause and effect
relationship cannot be clearly established.22
Figure 1 is an algorithm for assessing patients with joint pain.
Principles of Therapy
Current nonpharmacologic and pharmacologic therapies for OA provide symptomatic relief but are not curative
and do not slow disease progression. Several evidence-based guidelines are available for the management of
OA.23,24,25 Choice of treatment is based on a combination of risk vs. benefit assessment, cost and patient
preference. Pharmacologic therapy should always be initiated in combination with nonpharmacologic
modalities. If tolerated, pharmacologic therapies (except localized therapy) should be tried for at least 1–2
weeks to allow the patient to fully assess their effectiveness. An algorithm for treatment of osteoarthritis can
be found in Figure 2.
Nonpharmacologic therapy for OA (Table 2) should always be initiated first or started concurrently with drug
therapy. The quality of published evidence supporting these modalities is varied.27 There is reasonably good
evidence that self-management education programs can improve mobility and reduce discomfort.28,29 In
addition, evidence suggests that aerobic exercise and strength training,30,31,32,33,34 weight loss through a
combination of diet and exercise,35 and supports and braces36,37,38,39,40 may effectively reduce symptoms
and improve function. Therapies that actively engage the patient (e.g., aerobic, aquatic and strength exercises)
may be more effective than passive therapies (e.g., diathermy, orthotics, magnetic stimulation).51 Consider
referring patients who wish to evaluate these options to a physiotherapist or occupational therapist.52
Surgery is usually reserved as a last resort for patients with severe, painful and activity-limiting OA who have
tried other pharmacologic and nonpharmacologic modalities.23,24,25
27
Table 2: Nonpharmacologic Therapy for Osteoarthritis
Modalities Supported by Evidence Purpose/Benefits
Patient education for self- Educate about treatment options and coping skills
management28,29 Reduce pain and disability
Strength training and aerobic Reduce pain and disability in knee, hip osteoarthritis (OA)
exercise30,31,32,33,34 (includes land and Intensity not important
aquatic exercise)
Weight loss if overweight/obese, Decrease load on weight-bearing joints

through diet and exercise (weight loss Improve pain and function in knee OA
of at least 5%)35
Joint protection, e.g., splints, taping, Ensure joint properly positioned during activity and at rest
braces36,37,38 Improve pain and joint function in knee OA
Supportive footwear, e.g., no raised heel; Absorbs shock and controls foot pronation
thick, shock-absorbing sole; arch Improve pain and physical function
support; adequately sized36,38,39,40
Use of ambulation aids and assistive May improve functional status, ambulation
devices, e.g., canes, walkers24 Facilitate activities of daily living (ADL)
Social support, e.g., telephone follow Improve pain and psychological status
up,28,41,42 education of family members
and caregivers43
Transcutaneous electrical nerve Improve pain and stiffness in knee OA

stimulation (TENS)44
Modalities Supported by Evidence Purpose/Benefits
Acupuncture25,45,46 Improve pain, stiffness, function in knee OA
Heat47 Increase blood flow to affected areas

Apply for 10 min prior to strength training exercises for
knee OA
Cold48 Reduce blood flow to affected area, block nerve impulses

to joints, reduce swelling
Improve range of motion, function and knee strength
Massage ice around affected joint for 20 min, 5 times per
wk
Massage49 Small trial suggests may improve pain, stiffness and

function in knee OA
Massage produces counterirritation
Surgery24,25,50 Indicated in patients with severe symptomatic OA who

have failed nonsurgical strategies and continue to have
significant limitations in ADL
Table 5 lists selected oral and topical medications used to treat osteoarthritis.24,25,50
For more information on pharmacologic therapy, consult the Compendium of Therapeutic Choices:
Osteoarthritis.
Ailments—Analgesic Products: External Analgesics, Internal Analgesics and Antipyretics.
Acetaminophen
Acetaminophen continues to be the initial drug of choice for symptomatic relief of osteoarthritis.24,25 The
rationale for using acetaminophen has been the fact that it is effective, relatively safe, well tolerated and
easily accessible. Most studies of acetaminophen in OA used the maximum daily dose of 1 g QID for a
short period (median 6 weeks) and show that it provides moderate pain relief and improvements in
function.55,56 However, 2 meta-analyses showed that acetaminophen likely has a small effect on OA pain
and may not be sufficient to treat OA of the knee or hip.57,58 Maximum therapeutic doses should be tried for
an adequate period (1–2 weeks) to assess efficacy. Following this trial, the lowest effective dose should be
used.
Acetaminophen overdose is the leading cause of acute liver failure, which led the US Food and Drug
Administration to recommend that all products containing acetaminophen be limited to 325 mg of
acetaminophen per dosage unit;59 Health Canada continues to review the data to assess whether similar
changes will be made in Canada.60 Patients taking acetaminophen must be counselled to not exceed the
recommended daily dose and to be informed of nonprescription and prescription products that contain
acetaminophen.61 Conditions such as chronic alcohol abuse and liver disease preclude the long-term use
of maximum therapeutic doses and should be investigated prior to beginning therapy; however, they are not
contraindications to acetaminophen therapy.62,63,64
Topical Agents
Topical diclofenac and topical capsaicin are reasonable options for patients with OA of the knee who have
suboptimal relief with acetaminophen, or who cannot tolerate or are reluctant to use systemic agents.24,25
Initial NSAID therapy should be topical rather than oral in persons ≥75 years old.25 Both agents are effective
in those who have OA in only 1 or 2 joints, such as the knee or hand.65,66,67,68,69 Several systematic reviews
have shown that topical NSAIDs are better tolerated than oral NSAIDs and have similar effects on pain and
function.65,66,67 In a Cochrane review, the proportion of patients with osteoarthritis who experienced a 50%
reduction in pain over 8–12 weeks compared with placebo was 48% vs. 32% (NNT=6) for topical diclofenac
solution and 60% vs. 51% (NNT=11) for topical diclofenac gel.70 Systematic reviews have also shown
topical capsaicin to be efficacious for the treatment of chronic pain. The proportion of patients who
experienced a 50% reduction in pain after 4 weeks compared with placebo was 38% vs. 25% (NNT=8) for
capsaicin 0.025% and 57% vs. 42% (NNT=6) for capsaicin 0.075%.68,69
Zucapsaicin, a synthetic form of capsaicin, is indicated for the management of severe pain from knee
osteoarthritis not managed by NSAIDs alone. A 3-month phase III clinical trial showed that in patients with
severe pain despite NSAID or COX-2 inhibitor therapy, adding topical zucapsaicin 0.075% cream improved
both pain and function compared to zucapsaicin 0.01% (used as the control).71
Topical therapies may also be tried as an adjunct to systemic agents where pain relief is not adequate. Both
agents should be applied 3–4 times daily. Maximal effect can take up to 2 weeks for topical NSAIDs and 4
weeks for topical capsaicin. Unfortunately, the tingling and burning sensation caused by capsaicin often
prevents an adequate trial of this medication.
A systematic review found little evidence to support the use of topical counterirritants such as salicylates in
chronic musculoskeletal pain.72 Since they are readily available without a prescription, the potential exists
for overuse of these products leading to bleeding from salicylate toxicity or drug interactions with oral
anticoagulants.73
Early randomized trials of topical herbal preparations suggest that Arnica or comfrey may also provide
symptom relief but further research is needed to understand the clinical significance of these findings.74
If patients experience pain, swelling or burning from topical analgesics, advise them to stop using the
product and seek immediate medical attention.75
NSAIDs
Due to their risk of serious adverse effects, nonsteroidal anti-inflammatory drugs (NSAIDs) are considered
second-line therapy after failure of acetaminophen in the management of OA pain.24,25 Although
acetaminophen is superior in terms of safety, NSAIDs are often preferred by OA patients due to better pain
relief.76,77 Not surprisingly, patients who discontinue NSAID use due to toxicity are less willing to resume
therapy with another NSAID.76
Celecoxib is as effective as nonselective NSAIDs for pain control in OA of the hip and knee and is
associated with a lower incidence of gastroduodenal ulcers compared with nonselective NSAIDs.78 Like
nonselective NSAIDs, celecoxib can exacerbate pre-existing renal disease. Baseline and periodic monitoring
of serum creatinine and electrolytes is recommended for high-risk patients.
Prior to starting long-term NSAID therapy, assess patients for their risk of cardiovascular, GI and renal
complications (see Table 3).78,79,80,81 If a patient has no risk factors, a low-dose of a nonselective NSAID
can be started (e.g., ibuprofen 200–400 mg Q8H or naproxen sodium 220 mg Q12H). Over a 1- to 2-week
trial, the dose can be titrated until adequate pain relief is achieved or the maximum dose is reached. Avoid
long-term therapy if possible, but if continued therapy is needed, use the lowest effective dose. Patients
who require chronic NSAID therapy should discuss their use with a healthcare practitioner. Due to the
serious adverse effects associated with ASA it is not generally recommended for the self-management of
OA.
Avoid most NSAIDs (including COX-2 inhibitors) in patients at increased risk of cardiovascular events. If
treatment with an NSAID is essential, patients at high risk of cardiovascular complications should receive
naproxen (with low-dose ASA, if indicated). Nonselective NSAIDs may inhibit the antithrombotic effect of
ASA by competitively binding to the COX-1 receptor.82 This theoretical interaction has not been documented
with enteric-coated ASA or COX-2 inhibitors. Advise patients to take nonselective NSAIDs at least 30
minutes after or 8 hours before ASA.83
There are no definitive data to indicate the superiority or safety of one NSAID over another but both the
Canadian Cardiovascular Society78 and the American Heart Association79 have released position
statements to guide the use of NSAIDs.
Table 3: Risk Factors for the Development of Serious Adverse Events with NSAID Therapy
Cardiovascular GI Complications Renal Complications
Complications
Age >65 y >65 y >65 y
Medical History Heart failure Alcoholic liver disease Heart failure

CV disease H. pylori infection Dehydration
Diabetes Peptic ulcer disease Hypertension
Hypertension Rheumatoid arthritis Pre-existing renal disease
Myocardial Upper GI bleeding
infarction
Stroke
Rheumatoid
arthritis
Concomitant Regular use of multiple ACE inhibitors

Medications NSAIDs ARBs
Antithrombotic, e.g., daily Direct renin inhibitors
low-dose ASA, warfarin
Diuretics
Oral glucocorticoids
Abbreviations: ARB = angiotensin receptor blocker; CV = cardiovascular
NSAID Risks
While dyspepsia has been reported in up to 60% of patients taking NSAIDs, the actual incidence is likely
closer to 5–10%.84 If dyspepsia occurs for more than 7 days in a month, consider discontinuing NSAID
therapy.85 Minor heartburn can be managed symptomatically with antacids or histamine-2 receptor
antagonists (see Dyspepsia and GERD).
Serious GI complications such as perforated ulcers, hemorrhage and obstruction are estimated to occur
at an incidence of less than 1% per year.86 Prior to starting NSAID therapy, identify patients at risk of
serious NSAID-related GI complications and take preventive measures (see Figure 2). Histamine-2
receptor antagonists and antacids provide relief from dyspeptic symptoms, but not against more
serious GI complications. Misoprostol and proton pump inhibitors (PPIs) such as omeprazole are
appropriate options for preventing serious GI complications, though PPIs are much better
tolerated.87,88,89,90,91
NSAIDs can increase blood pressure in patients with normal or high blood pressure.92,93 When starting
NSAIDs in patients on antihypertensive therapy, measure blood pressure within 1 week of starting
treatment to assess whether changes to either NSAID or antihypertensive therapy are warranted. In
addition to affecting blood pressure, NSAIDs can cause acute kidney injury, especially when added to
antihypertensive therapies like diuretics, ACE inhibitors or angiotensin receptor blockers.94
Meta-analyses of both randomized controlled trials and observational studies have shown that NSAIDs
increase the risk of thromboembolic cardiovascular events such as MI.95,96,97 With the exception of
naproxen, this risk has been shown with most NSAIDs, including several COX-2 inhibitors and
nonselective agents such as ibuprofen and diclofenac. It is still unclear whether the use of low-dose
acetylsalicylic acid (ASA) in high-risk patients mitigates this risk.96,98
Ailments—Herbal and Natural Health Products: Combinations, Single Entity.
Endogenous glucosamine and chondroitin maintain the integrity of cartilage within a joint. Exogenous
formulations (glucosamine sulfate, glucosamine hydrochloride, chondroitin sulfate) have been evaluated in
the treatment of OA. Their pharmacologic effect is believed to mimic their physiologic effect on cartilage
tissue. The proposed mechanisms of action are to stimulate the production of cartilage, prevent cartilage
destruction by inhibiting inflammatory mediators and/or enzymes and maintain viscosity of the joint.99,100
The majority of available evidence suggests that glucosamine hydrochloride is ineffective for pain reduction
in patients with OA. One study of glucosamine hydrochloride plus chondroitin compared with celecoxib in
patients with knee OA suggested comparable efficacy in reducing pain scores after 6 months.101 The study
lacked a placebo arm, which is concerning as up to 75% of the effect of analgesics in OA may be due to
placebo effect.102 Glucosamine sulfate may have function-modifying effects in patients with knee OA when
administered for more than 6 months, but no pain-reduction benefits were demonstrated after 6 months of
therapy.103 A systematic review evaluating the benefit and harm of chondroitin for OA found that
chondroitin, alone or in combination with glucosamine, was better than placebo in improving pain and had
lower risk of serious adverse events compared to control.104 A large-scale randomized controlled trial in
knee OA compared the combination of glucosamine HCl (500 mg TID) and chondroitin sulfate (400 mg TID)
to either placebo or celecoxib (200 mg daily). Celecoxib was the only intervention that proved efficacious. A
small subset of patients with moderate to severe pain experienced some pain relief with the combination of
glucosamine and chondroitin.105 In another randomized controlled trial, glucosamine sulfate (1500 mg
once daily) failed to improve pain, function or the number of medications taken in patients with hip OA.106
As large-scale randomized controlled trials have not shown glucosamine and chondroitin to have
substantial effect, treatment guidelines for OA do not recommend these agents.25,107,108,109 However,
given the great interest that many patients have in “natural” alternatives, it is worthwhile having a discussion
with patients about the most recent evidence.
S-adenosyl-L-methionine (SAMe) is a naturally occurring substance that is produced by the body. It may
promote the production of cartilage building blocks. A systematic review suggests that SAMe is well
tolerated and may improve both pain and function in osteoarthritis.110 However, a 2009 Cochrane review
noted that many of the trials were small, not placebo-controlled and of questionable quality. Reviewers
cautioned against using SAMe until adequately sized, randomized, parallel-group trials have been done.111
Other complementary and alternative products such as methylsulphonylmethane (MSM), Indian

frankincense, avocado–soybean unsaponifiables (ASU) and rose hip may also be effective but high quality
evidence is lacking.110,112
Localized Therapy
The use of intra-articular corticosteroids in OA is limited to acute knee pain and patients who have local
signs of inflammation and joint effusion. If joints are painful and swollen, aspiration of fluid followed by
intra-articular injection of a corticosteroid (e.g., triamcinolone acetonide or methylprednisolone acetate) is
effective in temporarily (4–6 weeks) decreasing pain.113 It is often used in combination with other
therapies, although it can be used as monotherapy. Repeated injections may damage cartilage. The
injection should be provided by a qualified healthcare practitioner and the same site should not be injected
more than 3–4 times per year.23
The efficacy of intra-articular corticosteroids for hand and hip OA has not been studied and use is not
routine due to the risk of cartilage damage through repeated injections. Rheumatologists, using
radiographic guidance, may provide injections to these joints for certain patients.
Hyaluronan is a linear polysaccharide found in synovial fluid. Meta-analyses investigating the efficacy and
safety of hyaluronan injections have found conflicting results.57,114,115 The effect of repeated courses of
hyaluronan injections is unknown. These products are usually reserved for patients who have failed other
therapies. Costs are high ($200–400 per treatment course) and they are not routinely covered by insurance
plans. The injections can be purchased without a prescription but they must be administered by a qualified
Opioid Analgesics
An opioid analgesic alone or in combination with acetaminophen or NSAIDs may be useful in patients who
do not respond to other analgesics, experience acute exacerbations of OA pain, or are not willing or able to
receive surgical treatments.24 Side effects such as sedation, constipation, tolerance and dependence may
limit the long-term use of these agents in many patients. However, the high risk of serious adverse effects
from NSAIDs in the elderly limits their use in this population and opioids provide an alternative. The
American Geriatrics Society recommends a trial of opioids in carefully selected and monitored elderly
patients with moderate to severe persistent pain, pain-related functional impairment or diminished quality of
life due to pain.116
Evidence about the efficacy and safety of opioids in treating osteoarthritis pain has been contradictory. A
systematic review of long-term opioid therapy for chronic pain concluded that there is insufficient evidence
for improving chronic pain and function, and there is a dose-dependent risk of serious harms including
overdose, abuse and fractures.117 A Cochrane review of the effect of oral or transdermal opioids in knee or
hip OA similarly concluded that there is small mean benefit of non-tramadol opioids in OA, but it is
associated with a significant risk of adverse events.118
Numerous combination analgesic products containing codeine 8 mg are available. The effectiveness of
low-dose combination codeine products compared with single ingredient products (e.g., NSAIDs,
acetaminophen) for OA has not been adequately studied, but they may be reasonable options for individuals
at risk of serious adverse events from NSAIDs.24,25
Tramadol is a partial opioid agonist used for acute pain. It may be used as monotherapy or in combination
with acetaminophen or NSAIDs for OA of the hip and knee if treatment with these agents has not provided
adequate pain relief. Tramadol may have a small effect on pain and function, and the risk of abuse appears
to be low.119
Antidepressants
Duloxetine is an antidepressant approved for use in osteoarthritis of the knee. A pooled analysis of 2
randomized placebo-controlled trials showed the proportion of patients who experienced ≥ 50% reduction in
pain after 13 weeks with duloxetine compared with placebo was 47% vs. 31% (NNT=7). Duloxetine may be
used as monotherapy or in combination with acetaminophen or NSAIDs for OA of the hip and knee if
treatment with these agents has not provided adequate pain relief. Common side effects include nausea,
fatigue and constipation.120
Table 4 provides a monitoring plan for patients with osteoarthritis.
Table 4: Monitoring of Therapy for Osteoarthritis

Pain relief Elimination or Patient: Assess daily Patient may require further
improvement Healthcare practitioner: assessment if no symptom relief
toward Call on days 3, 7, 14 and after adequate trial of at least 2
predefined, 28 analgesics or on development of
realistic goals new or worsening pain during
as set by therapy.
patient Considerations:
Use visual analog scale or
other individual measure to
quantify and characterize pain
(e.g., ADL—walking, gardening)
Establish acceptable level of
pain control and functioning
with the patient at the
beginning of therapy
Timing of medications:
Around-the-clock vs. PRN
Take analgesic at least 1
h prior to activities that
may exacerbate pain.
Nausea, Minimal or Patient: Monitor daily Change therapy if symptoms severe

dyspepsia, none during Healthcare practitioner: or intolerable. Minimize
abdominal therapy Call on days 3 and 7 development by advising to take
discomfort with food or milk.
Consider antacids or H2RAs to treat
dyspepsia.
Hematemesis, None during Patient: Monitor daily on Assess risk of GI complications

melena, therapy an ongoing basis (Table 3). If high risk, patient
hematochezia Healthcare practitioner: requires further assessment and
Call on days 3, 7, 28 then workup.
ask when medication is Patient should discontinue therapy
refilled immediately and seek medical
attention if these signs or
symptoms develop.
Hypertension Stable during Healthcare practitioner: Monitor patients with pre-existing

therapy Measure BP within 1 wk of hypertension; if BP increases, adjust
starting NSAIDs the dose of the NSAID or
antihypertensive.
Renal function No significant Patient: Look for Assess risk of renal complications
and signs of change in decreased urine (Table 3).
fluid retention renal function production; watch for Hold NSAID that day if patient
(e.g., weight signs of fluid retention, cannot eat or drink.
gain or e.g., edema. Patients with
edema) in severe heart failure should Discontinue NSAID if significant
high-risk weigh themselves daily changes in serum creatinine or
patients electrolytes or if signs of fluid
Healthcare practitioner: retention occur.
Call on day 3 to ask about
urine production
In patients >65 y or with
other risk factors, consider
taking a baseline serum
creatinine, repeat at 1 wk
and then periodically
Abbreviations: ADL = activities of daily living; BP = blood pressure; H2RA = H2-receptor antagonist

Advise patients on:
The importance of using nonpharmacologic measures concurrently with medication therapy

Expected benefits of therapy
Possible side effects and their management
When to contact a healthcare practitioner.
Resource Tips
The Arthritis Society (National Office), 393 University Avenue, Suite 1700, Toronto, Ontario M5G 1E6. Tel.: 416-
979-7228. Available from: www.arthritis.ca.
Algorithms
Figure 1: Assessment of Patients with Joint Pain

a See Sports Injuries.
Figure 2: Treatment of Osteoarthritis

a 26
See Guidelines for prevention of NSAID-related ulcer complications.
Drug Table
Table 5: Selected Pharmacologic Therapy for Osteoarthritis


acetaminophen 325–1000 mg Hepatotoxicity: Acetaminophen Maximal onset

Atasol Preparations, Tylenol, Q4–6H po increased risk in has been of pain relief
generics SR: 650 mg Q8H patients with reported to within 24–48 h.
po excessive increase INR in Lower doses
$ alcohol intake warfarin-treated
Maximum: may be required
(>3 drinks/day), patients.53 Check in patients with
4 g/day malnourishment INR if severe hepatic
or pre-existing acetaminophen and renal
hepatic disease. ≥2 g/day is used disease.
Baseline LFTs for ≥3
should be Caution with
consecutive days.
measured in concurrent use
Adjust warfarin
high-risk of other
dosage as
patients. products
required.
containing
Phenytoin, acetaminophen
may increase
Consider
acetaminophen
continuous
metabolism and
therapy in
formation of toxic
individuals with
metabolite
pain persisting
(increased risk of
throughout the
hepatotoxicity);
day. PRN dosing
risk may be
is acceptable
increased in
for episodic
patients taking
pain of short
high therapeutic
duration.
doses of
acetaminophen
and antiepileptic
drugs chronically.
acetaminophen/caffeine/codeine 1–2 tablets Q4– Hepatotoxicity: Acetaminophen Recommended

8 mg 6H po increased risk in has been for short-term
generics Maximum: patients with reported to use only, e.g., 2–
4 g/day of excessive increase INR in 3 days.
$ acetaminophen alcohol intake warfarin-treated Elderly are at
from all sources (>3 drinks/day), patients.53 Check increased risk
malnourishment INR if for adverse
or pre-existing acetaminophen effects.
hepatic disease. ≥2 g/day is used
Baseline LFTs Caution with
for ≥3
should be concurrent use
consecutive days.
measured in of other
Adjust warfarin
high-risk products
dosage as
patients. containing
required.
acetaminophen
Sedation, Phenytoin, (do not exceed
nausea, barbiturates, 4 g/day).
vomiting, carbamazepine
constipation. may increase
acetaminophen
metabolism and
formation of toxic
metabolite
(increased risk of
hepatotoxicity);
risk may be
increased in
patients taking
high therapeutic
doses of
acetaminophen
and antiepileptic
drugs chronically.
Concurrent use of
medications that
cause CNS
depression (e.g.,
sedatives,
tranquilizers,
alcohol) or
constipation may
increase these
effects.
Drug Class: Analgesics, topical

capsaicin Apply sparingly Tingling, burning None known. Pain relief may
Zostrix, Zostrix HP, generics TID–QID for 3–4 or redness Concurrent use of take up to 2 wk
wk to achieve (majority of other topical with daily use.
$$ maximum patients). Maximum effect
medications on
therapeutic areas treated with can take up to 4
effect capsaicin should wk.
be avoided. Apply with
gloves and
wash hands
thoroughly after
application to
avoid irritation
of other areas.
Tingling/burning
usually
decreases
within 72 h with
repeated use; if
effect is
bothersome,
use lower
concentration or
pretreat with
topical lidocaine
or EMLA cream.
Do not apply
near mucous
membranes or
on broken skin.
Do not cover
with tight or
occlusive
dressing. Do not
place heating
devices (e.g.,
hot water bottle,
heating pad) on
skin after
applying
product.
zucapsaicin Apply TID Transient None known. Approved in

Zuacta burning on Concurrent use of adults for
application. other topical adjunctive use
$$$$$ with oral
medications on
areas treated with NSAIDs for
zucapsaicin severe pain in
should be OA of knee for
avoided. maximum of 3
months.
Avoid contact
with eyes or
open lesions.

ibuprofen 200–400 mg More common: Warfarin Renal effects
Drug/ CostaLiqui-Gels, Motrin,
Advil, Advil
Dosage
Q6–8H po
Adverse
Dyspepsia,
Drug
(increased
Comments
are more likely
Motrin IB, Motrin Liquid Gels, Maximum dose Effects
diarrhea. Interactions
bleeding risk); in the elderly or
generics for self-care: More serious: monitor INR more patients with
1200 mg/day for Ulceration/upper frequently during pre-existing
$ up to 5 days initial period after renal disease or
GI bleed,
Usual maximum exacerbation of starting drug and comorbid
dose: heart failure, MI, watch for signs conditions that
2400 mg/day stroke, acute of bleeding. may affect renal
renal failure, Increased lithium function (e.g.,
transient levels; monitor. diabetes, heart
elevated liver failure,
Increased hypertension).
enzymes, rare methotrexate
hepatotoxicity. levels (rare, with Advise patients
high doses MTX); to stop taking
monitor for NSAID if unable
toxicity. to eat or drink
that day.
Antihypertensives
(e.g., beta- Hepatotoxicity
blockers, ACEI, is more likely to
diuretics): may occur in
decrease patients with
antihypertensive pre-existing
effects. Measure hepatic disease
baseline BP, then or those with
remeasure in 1–2 excessive
wk and adjust alcohol intake
antihypertensive (>3 drinks/day).
therapy as Consider
required. continuous
Increased risk of therapy in
GI bleed with individuals with
SSRIs. pain persisting
throughout the
Increased risk of day; PRN dosing
GI adverse is acceptable
effects with for episodic
alcohol. pain of short
Give 30 min after duration.
or 8 h before low- Consider
dose ASA. gastroprotection
in high-risk
patients (see
Table 3).
Avoid in patients
with ASA or
ibuprofen
hypersensitivity.
NSAIDs are not
a substitute for
low-dose ASA
therapy for MI or
stroke
prophylaxis.
Avoid
concurrent use
of more than
one NSAID-
containing
product due to
increased risk of
Effects Interactions GI side effects—
the only
exception is
low-dose ASA
for
cardiovascular
protection.
Increased risk of
stroke or
serious CV
events at doses
≥2400 mg/day.
Doses ≥2400
mg/day should
not be used in
patients with a
history of CV
events or with
risk factors for
CV disease.54
naproxen 250–500 mg More common: Warfarin Renal effects

Naprosyn, generics BID po Dyspepsia, (increased are more likely
diarrhea. bleeding risk); in the elderly or
$$ monitor INR more patients with
More serious:
Ulceration/upper frequently during pre-existing
GI bleed, initial period after renal disease or
exacerbation of starting drug and comorbid
heart failure, MI, watch for signs conditions that
stroke, acute of bleeding. may affect renal
that day.
Antihypertensives
wk and adjust alcohol intake
antihypertensive (>3 drinks/day).
therapy as Consider
required. continuous
Increased risk of therapy in
GI bleed with individuals with
SSRIs. pain persisting
throughout the
Increased risk of day; PRN dosing
GI adverse is acceptable
for episodic
effects with pain of short
Drug/Costa Dosage Adverse Drug
alcohol.
Comments
duration.
Give 30 min after Consider
or 8 h before low- gastroprotection
dose ASA. in high-risk
patients (see
Table 3).
Avoid in patients
with ASA or
ibuprofen
hypersensitivity.
NSAIDs are not
a substitute for
low-dose ASA
therapy for MI or
stroke
prophylaxis.
Avoid
concurrent use
of more than
one NSAID-
containing
product due to
increased risk of
GI-related side
effects—the only
exception is
low-dose ASA
for
cardiovascular
protection.
naproxen sodium Immediate- More common: Warfarin Renal effects

Aleve, Anaprox, generics release: 220– Dyspepsia, (increased are more likely
550 mg BID po diarrhea. bleeding risk); in the elderly or
$ Maximum dose monitor INR more patients with
More serious:
for self-care: Ulceration/upper frequently during pre-existing
440 mg daily GI bleed, initial period after renal disease or
exacerbation of starting drug and comorbid
heart failure, MI, watch for signs conditions that
stroke, acute of bleeding. may affect renal
that day.
Antihypertensives
wk and adjust
antihypertensive alcohol intake
Drug/Costa Dosage Adverse Drug
therapy as
Comments
(>3 drinks/day).
required. Consider
Increased risk of continuous
GI bleed with therapy in
SSRIs. individuals with
Increased risk of pain persisting
GI adverse throughout the
effects with day; PRN dosing
alcohol. is acceptable
for episodic
Give 30 min after pain of short
or 8 h before low- duration.
dose ASA.
Consider
gastroprotection
in high-risk
patients (see
Table 3).
Avoid in patients
with ASA or
ibuprofen
hypersensitivity.
NSAIDs are not
a substitute for
low-dose ASA
therapy for MI or
stroke
prophylaxis.
Avoid
concurrent use
of more than
one NSAID-
containing
product due to
increased risk of
GI-related side
effects—the only
exception is
low-dose ASA
for
cardiovascular
protection.
Drug Class: NSAIDs, topical

diclofenac diethylamine Apply TID–QID Skin dryness or With significantly Available as

Voltaren Emulgel, Voltaren Recommended irritation, lower amounts of 1.16% and
Emulgel Extra Strength treatment hypersensitivity. medication in 2.32% gel.
duration of 7 Serious GI circulation Do not apply
$ toxicity has not following topical
days. If pain near mucous
does not been seen to application membranes or
improve or date in clinical (approximately on broken skin.
becomes worse trials. 6% absorbed) vs. Do not cover
within the oral with tight or
recommended administration, occlusive
duration of use, drug interactions dressing. Do not
re-evaluate are unlikely with place heating
therapy use of topical devices (e.g.,
diclofenac. See hot water bottle,
ibuprofen for heating pad) on
potential skin after
interactions. applying
product.
diclofenac sodium Apply TID–QID Skin dryness or With significantly Available as

Pennsaid, generics Recommended irritation, lower amounts of 1.5% lotion.
treatment hypersensitivity. medication in Do not apply
$$$$ Serious GI circulation
duration ≤3 near mucous
months. If pain toxicity has not following topical membranes or
does not been seen to application on broken skin.
improve or date in clinical (approximately Do not cover
becomes worse trials. 6% absorbed) vs. with tight or
within the oral occlusive
recommended administration, dressing. Do not
duration of use, drug interactions place heating
re-evaluate are unlikely with devices (e.g.,
therapy use of topical hot water bottle,
diclofenac. See heating pad) on
ibuprofen for skin after
potential applying
interactions. product.
methyl salicylate Apply TID–QID Skin irritation. Warfarin: may Avoid in ASA-
Rub A-535, others increase allergic patients.
anticoagulant Avoid contact
$ effect. with eyes and
mucous
membranes.
a
Cost of 1 week of therapy or smallest available pack size; includes drug cost only.
Abbreviations: ACEI = angiotensin converting enzyme inhibitor; BP = blood pressure; EMLA = lidocaine-prilocaine topical
anesthetic; INR = international normalized ratio; LFT = liver function tests; SR = sustained release
Legend: $ <$10 $$ $10–20 $$$ $20–30 $$$$ $30–40 $$$$$ $40–50
Suggested Readings
Osteoporosis
Lalitha Raman-Wilms, PharmD, FCSHP

Anne Marie Whelan, PharmD, FCSHP
Introduction
Osteoporosis is a common skeletal disorder that results in more than 8.9 million fractures annually worldwide.1 It is
characterized by compromised bone strength, resulting in a fragile skeleton vulnerable to fractures. Bone strength is determined
by both bone quantity, measured by bone mineral density (BMD) and quality.2
Osteoporosis affects about 1 in 4 women and 1 in 8 men in Canada over 50 years of age.3 Individuals with osteoporosis can
suffer from chronic disabling pain and loss of height from vertebral fractures. In severe cases, kyphosis (curvature of the spine
or hunching) can cause shortness of breath and dysphagia. In individuals who have sustained a hip fracture, mortality in the first
year has been reported to be as high as 28% in women and 37% in men.4
The relationship between fractures and mortality was studied in a subgroup from the Canadian Multicentre Osteoporosis Study.
The results demonstrated that men and women ≥50 years with hip or vertebral fractures were more likely to die during the 5
years of follow up, compared with those without these fractures.5 However, possibly due to better availability of diagnostic and
treatment modalities, analysis of Canadian data in those hospitalized for hip fracture between 1985 and 2005 indicate that hip
fracture rates show a steady decline, with the greatest decrease seen between 1996 and 2005.6
Hip fracture is one of the leading causes of institutionalization in the elderly. A fear of falling and decreased functioning can lead
to social isolation, anxiety and depression. Osteoporosis also results in complications such as loss of independence and
nursing home admissions, secondary to fractures. The economic implication of hip fractures alone in Canada was an estimated
$650 million in 2001, and the annual cost of acute care management associated with osteoporosis is expected to rise to $2.4
billion dollars by 2041.7
Pathophysiology
Bone is constantly renewed. The bone-remodelling unit consists of osteoblasts (cells that lay down new bone) and osteoclasts
(cells that resorb bone). The coupling of this process ensures that early in life, more bone is laid down as the child grows.
Although up to 90% of bone mass is attained in girls at age 18 and in boys at age 20, the coupling process continues and
reaches a plateau whereby the amount of bone broken down is balanced by the amount of new bone formed. At this point,
usually around the age of 30, individuals attain their peak bone mass or their highest BMD.8 After the third decade, age-related
changes favour resorption, resulting in a gradual loss of 0.3–0.5% of bone mass per year. In women, a decrease in estrogen at
menopause leads to accelerated bone loss of 2–3% per year; this loss continues for the first 5–10 years after menopause.
Women have a lower peak bone mass compared with men, further increasing their risk of osteoporosis.8,9
Most of the body's calcium is stored in bone. Calcium is essential for functions such as muscle contraction and nerve
conduction. With insufficient calcium intake, parathyroid hormone (PTH) is released, leading to reduced excretion of calcium
from the kidney, increased calcium resorption from bone and vitamin D activation by the kidneys. An increase in vitamin D
activation results in increased calcium absorption from the GI tract. This feedback normally helps maintain an adequate serum
calcium level. Deficiency in vitamin D can result in secondary hyperparathyroidism and increased calcium resorption from
bone.10
The World Health Organization has established guidelines for the diagnosis of osteoporosis based on BMD readings at the
lumbar spine and femoral neck. Osteoporosis is defined as a BMD of 2.5 standard deviations (SD) or more below the average
for young, healthy women (T-score of ≤ −2.5 SD).1,11 A BMD between −1 and −2.5 signifies osteopenia.1,11 Diagnosis is usually
confirmed by measuring the individual's BMD using dual energy x-ray absorptiometry (DXA), which is considered best practice.
In those who have sustained fractures, an x-ray is usually used to confirm the fracture.
Clinically, osteoporosis may present with fractures ± pain associated with fractures. Common sites for fracture include the wrist,
spine and hip. Wrist and spinal compression fractures are seen earlier in the disease, while hip fractures usually occur in the
seventh or eighth decade of life. Many patients may go undiagnosed, as often the only symptom is nonspecific chronic back
pain. The lifetime risk of fracture is about 30–40% for individuals in developed countries.9
Goals of Therapy
Prevent fractures by addressing clinical risk factors that increase fracture risk
Prevent development or progression of osteoporosis by maximizing and/or maintaining existing BMD
Minimize the risk of falls
Patient Assessment
Though the main indicator of osteoporosis is low BMD, bone strength is determined by both quantity and quality of bone, and
some individuals with normal BMD may sustain osteoporotic fractures. Hence, identification of risk factors for this disease is
important in assessing an individual's risk of fracture. In assessing a patient's risk factors for osteoporosis (Figure 1), consider
age, family history, medical conditions, diet, smoking, alcohol use and lifestyle. Use Table 1 and Table 2 to identify risk factors
for osteoporosis and fractures that would indicate the need to measure BMD.
Table 1: Osteoporosis Risk Factors: Indications for Bone Mineral Density Measurement
Older Adults (≥50 y) Younger Adults (<50 y)
Age ≥65 y (men and women) Fragility fracture
Clinical risk factors for fracture (men 50–64 y and Glucocorticoid use (prednisone-equivalent dose ≥7.5
menopausal women): mg/day for at least 3 months in the previous year)
fragility fracture after age 40 Use of other high-risk medications, e.g., aromatase
vertebral compression fracture inhibitors, androgen deprivation therapy
glucocorticoid use (prednisone-equivalent Hypogonadism or premature menopause (<45 y)

dose ≥7.5 mg/day for at least 3 months Malabsorption syndrome
(cumulative) in the previous year) Primary hyperparathyroidism
use of other high-risk medications, e.g., Other disorders strongly associated with rapid bone
aromatase inhibitors, androgen deprivation loss or fracture (Table 2)
therapy
parent with hip fracture
osteopenia identified on x-ray
current smoking
high alcohol intake
low body weight (<60 kg) or major weight
loss (>10% of weight at age 25)
rheumatoid arthritis
other disorders strongly associated with
osteoporosis (Table 2)
Adapted with permission from: Papaioannou A, Morin S, Cheung AM et al. 2010 clinical practice guidelines for the diagnosis and management of
osteoporosis in Canada: summary. CMAJ 2010;182:1864-73.
Some medical conditions and drug therapies are associated with an increased risk of osteoporosis (Table 2). Monitor patients
on medications associated with the development of osteoporosis closely. A thorough medication history may identify drugs that
increase the risk of osteoporosis in patients with other risk factors (Table 2). Minimization of drug-related risk is a component of
the overall management strategy.
A propensity to fall increases the patient's risk of a fracture. Factors that can increase the risk of falls (and fractures) should
therefore be assessed. In the elderly, this may include poor eyesight, poor lighting in hallways and loose rugs. Ensuring that
nonslip mats are placed in bathtubs and avoiding the use of bath oils in the tub can prevent falls. Drugs such as
benzodiazepines, tricyclic antidepressants and antipsychotic agents have been associated with an increased risk of falls.29,30
Individuals who have sustained a fracture, have one or more risk factors, or who are at moderate to high risk of fractures based
on the 10-year fracture risk assessment (see Assessment of Fracture Risk) require further assessment and consideration of
drug therapy.12
Table 2: Medical Conditions and Drugs Commonly Associated with an Increased Risk of Osteoporosis
Conditions9,13 Drugs
Anorexia nervosa Antiepileptic drugs, e.g., phenytoin14,15

Bulimia
Antiretrovirals, e.g., protease inhibitors16,17,18
Chronic inflammatory conditions, e.g., inflammatory bowel
Chemotherapeutic agents, e.g., aromatase inhibitors,
disease
androgen deprivation therapy12,19,20
Chronic kidney disease
Cushing's syndrome Corticosteroids, e.g., prednisone21
Diabetes, type 1 Cyclosporine22

Gastrectomy Heparin (long-term therapy)23
Hyperparathyroidism, primary
Hyperthyroidism (untreated) Levothyroxine (in doses that suppress serum TSH in
Hypogonadism (untreated) postmenopausal women)24
Liver disease Loop diuretics22
Malabsorption syndromes including celiac disease Medroxyprogesterone acetate25
Menopause, prior to age 45 (untreated)
Proton pump inhibitors26,27,28
Neoplasia
SSRIs22
Osteogenesis imperfecta in adults
Thyrotoxicosis Thiazolidinediones22
Vitamin A22
Assessment of Fracture Risk
Patient assessment for osteoporosis should include the individual's risk factors for osteoporosis, fracture and falls. Two
related tools are available for assessing a patient's risk of fractures: the World Health Organization (WHO) FRAX Risk
Assessment Tool31 and the Canadian Association of Radiologists and Osteoporosis Canada (CAROC) risk assessment
tool.32
FRAX is an algorithm developed to predict an individual's 10-year fracture risk. It incorporates assessment of clinical risk
factors (sex, age, body mass index, prior fracture, parental hip fracture, prolonged glucocorticoid use, rheumatoid arthritis,
current smoking, alcohol intake) and (optionally) the femoral neck BMD. This tool is appropriate to use for both men and
women and is specific for use in Canadians. It is available from www.shef.ac.uk/FRAX/tool.jsp.12
The CAROC guidelines for fracture risk assessment assign an initial risk category based on sex, age and femoral neck BMD.
Certain risk factors, i.e., a prior fragility fracture or glucocorticoid use, raise the initial risk category to the next level; having
both of these risk factors places the individual in the highest risk category.12
The 10-year fracture risk is classified as low (<10%), moderate (10–20%) or high (>20%); this classification can better guide
management of osteoporosis. An individual's risk can vary over time, and should be re-evaluated every 5–10 years in those
with low risk, and every 1–5 years in those with moderate risk.12 This tool is available from
www.osteoporosis.ca/multimedia/pdf/CAROC.pdf.
Management of Patients Based on Risk-factor Assessment
The 2010 Canadian guidelines recommend:12

All patients at risk of osteoporosis should participate in lifestyle measures such as performing regular weight-bearing
exercise, ensuring adequate calcium and Vitamin D intake, initiating fall prevention strategies and stopping smoking
Patients who are categorized as being at low risk of fracture after their assessment should undertake, as appropriate,
the lifestyle measures previously mentioned
Management strategies for patients at moderate risk should be individualized
Pharmacologic therapy is recommended for those at high risk of fracture.
Prevention
Strategies for preventing osteoporosis should be considered at a young age. In children, adolescents and young adults, ensuring
sufficient exercise and adequate calcium, vitamin D and protein intake will help maximize peak bone mass.9 In middle-aged and
older adults, these same strategies can help maintain bone mass. The diet is the best source of calcium and vitamin D. Calcium
and/or vitamin D supplementation is recommended for those whose diet is inadequate to meet daily requirements.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Vitamin and
Mineral Products: Single Entity, Solid Combinations.
Adequate dietary calcium, vitamin D and protein intake, in addition to regular exercise and lifestyle changes, such as minimizing
caffeine and alcohol intake, are all important in maintaining bone mass.9 For those with osteoporosis, implement strategies to
prevent falls. Referral to an occupational therapist for a home safety assessment may be beneficial in the elderly.
For those in nursing homes, the use of hip protectors and exercise help minimize the risk of fractures.33 Multiple strategies to
prevent falls should be individualized based on the resident’s level of risk and lifestyle choices.
Direct exposure of the arms and legs to sunlight (ultraviolet B radiation) for 5–10 minutes allows the skin to synthesize vitamin
D; however, the amount is dependent on the time of day (best between 10 a.m. and 3 p.m.), season, latitude (exposure to UVB is
greater at latitudes <37°, i.e., closer to the equator), length of exposure and skin sensitivity.34 The elderly and individuals with
increased skin melanin pigmentation require longer periods of sun exposure to make the same amount of vitamin D3 as a
younger individual or one with less skin pigmentation. While it was thought that the application of sunblock decreased the
natural production of vitamin D by the skin,10,34 studies have determined that normal usage of sunscreen does not generally
result in vitamin D deficiency but does decrease the incidence of skin cancers.35 Most Canadians do not get sufficient vitamin D
based on sun exposure only and must obtain vitamin D via diet and supplements to prevent deficiency.
Dietary Measures
Adequate intake of calcium and vitamin D are essential, to help increase peak bone mass in the early years and to help
maintain bone mass later in life. Daily calcium needs are best met through dietary sources. A baseline calcium intake of
about 300 mg daily can be assumed, since many foods contain small amounts of calcium.36 Table 3 lists some calcium-rich
foods and their calcium content. Food sources of vitamin D include fatty fish (salmon, mackerel), fish liver oils and fortified
foods such as milk, bread, breakfast cereals, juices and margarine. Calcium and vitamin D requirements vary by age and
gender37,38 (see Table 6).
37
Table 3: Selected Dietary Sources of Calcium
Food Portion Size Calciuma
Beans, baked 125 mL 75 mg
Bread, whole wheat 2 slices 40 mg
Broccoli, cooked 185 mL 50 mg
Cheese (cheddar, edam, gouda) 3 cm cube 245 mg
Cheese, mozzarella 3 cm cube 200 mg
Cottage cheese (2%, 1%) 125 mL 75 mg
Figs, dried 10 150 mg
Ice cream 125 mL 80 mg
Milk (2%, 1%, skim, chocolate) 250mL 300 mg
Orange juice, fortified 250 mL 335 mg
Rice or soy beverage, fortified 250 mL 300 mg
Salmon, with bones, canned 105 g 240 mg
Sardines, with bones 55 g 200 mg
Tofu, with calcium sulfate 84 g 130 mg
Yogurt, plain 185 mL 295 mg
a
Approximate values.
Exercise
Like muscle, bone is living tissue that responds to exercise by becoming stronger. Weight-bearing exercise in the young can
help increase peak bone mass; a 2014 meta-analysis found that weight-bearing exercise was most beneficial for improving
bone mineral content in prepubertal children.3,42 In older individuals (including postmenopausal women) regular weight-
bearing exercise such as walking or jogging can help maintain bone mass. A Cochrane systematic review demonstrated that
weight-bearing and/or non-weight-bearing exercises may prevent bone loss in postmenopausal women.43 Exercises that
strengthen core muscles and improve balance may also be beneficial.12 Additional benefits of exercising regularly include
increased muscle strength and flexibility, which can improve balance and minimize the risk of falls. Exercise, including
strength, balance, weight-bearing and agility training, was shown to reduce injurious falls (those requiring medical attention)
in a trial of 409 home-dwelling women aged 70–80 years.44
Lifestyle Changes
Recommend smoking cessation and minimizing alcohol and caffeine intake when identifying strategies to decrease the risk
of osteoporosis.2 Limiting the amount of caffeine-containing beverages (cola, hot chocolate, coffee, tea) to no more than 3
servings daily can help minimize calcium loss. Excessive alcohol consumption can affect calcium absorption and bone
formation, and increase the risk of falls. For general good health, limit alcohol consumption to no more than 2 drinks per
day.45
For further discussion of pharmacologic therapy for osteoporosis, consult the Compendium of Therapeutic Choices:
Osteoporosis.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Vitamin and
Mineral Products: Single Entity, Solid Combinations.
Calcium and vitamin D are important considerations in preventing bone loss and are recommended in addition to any
antiresorptive or anabolic (or any additional pharmacological) therapy that may be used (see Table 6).46
Calcium Supplements
To determine whether individuals are receiving sufficient calcium from their diet, the following calcium calculator may be
helpful: www.osteoporosis.ca/osteoporosis-and-you/nutrition/calculate-my-calcuim. If diet is not sufficient to meet the daily
calcium requirements, consider supplementation. Calcium supplements are available in various salt forms (Table 4); the
carbonate and citrate salts are commonly used. Calcium carbonate is most often recommended as it is inexpensive and is
available in many dosage forms. Both natural (e.g., from oyster shells) and synthetically produced sources are equally
effective. Individuals who may have decreased acid secretion, such as those on H2-receptor antagonists (e.g., ranitidine) or
proton pump inhibitors (e.g., pantoprazole), should consider supplementation with calcium citrate, as its absorption is not
affected by these agents. Patients should be aware of the differences in absorption in order to choose the appropriate
calcium salt for their needs.
Table 4: Elemental Calcium Content of Calcium Salts

Calcium Salt Elemental Calcium
Calcium carbonate 40%
Calcium citrate 21%
Calcium gluconate 9%
Calcium lactate 13%
Lead content of natural calcium supplements has been a concern. Although the amount of lead was variable among 17
different calcium carbonate products at doses used in osteoporosis, the lead content did not pose a risk to the patient.47 In
individuals taking calcium at much higher doses (e.g., as a phosphate binder in renal disease), lead content may be a more
important concern.47
Supplemental calcium can significantly slow the rate of bone loss in postmenopausal women.48,49 Calcium
supplementation, without the addition of Vitamin D or antiresorptive agents, has not been shown to decrease fracture risk.2
In the Women's Health Initiative trial, older postmenopausal women aged 50–79 who were randomized to calcium 1000
mg/day plus vitamin D 400 IU/day showed greater preservation of hip BMD, seen up to 9 years of follow up, and a
nonsignificant decrease in hip fractures.50 Limitations of this study include the age of women (young to sustain hip
fractures) and the fact that all women, including those in the control group, had a baseline daily intake of 1200 mg of
calcium.
A meta-analysis of randomised controlled trials evaluating the effects of calcium in those >50 years showed small increases
in BMD with both dietary and supplemental calcium. The authors concluded that this small increase in BMD may not
significantly decrease fracture risk on its own.51 A systematic review evaluating the effects of calcium in those >50 years
showed no association of dietary calcium with risk of fracture and small inconsistent benefits on fracture prevention with
calcium supplementation.52
Increased cardiovascular events have been reported in patients taking calcium supplements53,54,55,56 while other studies
have indicated no increase.57,58 The effect of daily calcium supplementation on cardiovascular events is still unclear. Those
who have inadequate intake should first consider increasing their dietary calcium, and when appropriate, adding calcium
supplements.
In a randomized, double-blind, placebo-controlled study of 3270 elderly institutionalized women, combined use of calcium
1200 mg daily and vitamin D 800 IU daily decreased the risk of nonvertebral fractures.59 Compared with placebo,
supplementation resulted in a relative reduction in incidence of hip fractures after 36 months of 23% (4.19% vs. 5.44%) and
of all nonvertebral fractures of 17.2% (7.8% vs. 9.42%).60 Benefit from supplementation was seen within 12 months of
treatment. All women had inadequate calcium intake at baseline (<800 mg/day) and 44% were vitamin D deficient (serum
25-hydroxyvitamin D level of <30 nmol/L). Based on available evidence, Osteoporosis Canada and the Society of
Obstetricians and Gynaecologists of Canada (SOGC) recommend optimizing calcium intake in all individuals, for preventing
and treating osteoporosis.12,46
Vitamin D Analogues
Vitamin D is essential for normal calcium absorption and good bone health. If vitamin D is deficient, less than 10% of
calcium is absorbed. As discussed previously (see Nonpharmacologic Therapy), vitamin D is produced in the body usually
through exposure to sunlight and is also absorbed from the diet. However, for adults over 50 years of age, and for those who
are homebound or institutionalized, a daily vitamin D supplement is recommended.3
Vitamin D 800 IU daily, when given with adequate calcium supplementation, has resulted in moderately increased bone
mass61 and decreased fracture risk in elderly men and women.59 A meta-analysis of randomized, controlled trials in
postmenopausal women (mean age 71–85 years) showed that vitamin D 700–800 IU/day was associated with a significant
reduction in the risk of hip and nonvertebral fractures.62 At lower doses of 400 IU/day, a decrease in nonvertebral fracture
was observed, but not a decrease in hip fractures. A Cochrane review also suggests that vitamin D alone appears unlikely to
prevent fractures; however, vitamin D with calcium may prevent hip fractures in older individuals.63,64 Vitamin D supplements
may increase muscle strength in adults with vitamin D deficiency,65 and supplements of 800–1000 IU daily reduced the risk
of falls in persons >60 years of age.66
The Osteoporosis Canada recommendation for those ≥50 years at moderate risk of deficiency is 800–1000 IU of vitamin D
daily. Daily supplementation with more than 1000 IU may be required to achieve optimal vitamin D status, and doses up to
2000 IU are considered safe.12,40 Ensure adequate calcium intake (Table 6) when supplementing with vitamin D.
Measuring serum 25-hydroxyvitamin D is unnecessary in adults at low risk of vitamin D deficiency. Measuring is appropriate
prior to initiation of pharmacologic therapy for osteoporosis, in those who have sustained recurrent fractures and in those
who continue to lose bone mass with treatment.12 Levels should be measured after 3–4 months of supplementation and not
repeated if serum concentrations >75 nmol/L are achieved.
Vitamin D is available as cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2). Calcitriol, an active form of vitamin D, is
recommended only in those who may have renal or hepatic impairment and are not able to activate vitamin D.
Bisphosphonates
Antiresorptive or anabolic pharmacologic therapy is recommended if the 10-year absolute fracture risk is greater than 20%
(high risk). In those with a moderate risk, management decisions should be individualized.12,46
Bisphosphonates increase bone density and decrease fractures and are usually considered first choice. Large RCTs have
demonstrated that both alendronate and risedronate decrease the risk of vertebral and hip fractures.67 Etidronate appears
to reduce vertebral fractures; however, clinical trials were not well designed.68 Injectable zoledronic acid also decreases
vertebral and hip fractures.69 Concern raised in one zoledronic acid trial69 over a possible association with increased risk of
atrial fibrillation was not supported by subsequent reviews.70,71
Side effects of bisphosphonates may include GI effects such as abdominal pain, dyspepsia and nausea. Rarely, they may
cause esophagitis or esophageal ulceration. Osteonecrosis of the jaw (ONJ) has been reported, more commonly in patients
with cancer and/or those who have received high doses of iv bisphosphonates; however, case reports and retrospective data
have identified ONJ in those taking oral bisphosphonates. The true incidence of bisphosphonate-associated ONJ,
particularly in those without cancer or those taking oral bisphosphonates, remains unclear.72 Atypical fractures of the femur
have also been reported, mainly when bisphosphonates were used long term.73,74,75,76 These adverse effects must be
considered when assessing the benefits of treatment for each patient.
Bisphosphonates are an appropriate option for both men and women with osteoporosis.12,77
Hormone Therapy
Hormone therapy (HT) reduces fracture risk in postmenopausal women; however, due to potential adverse effects of HT it is
usually recommended only for short-term treatment (<5 years) of menopausal symptoms.46,78 Evidence from RCTs with
standard doses of HT (0.625 mg conjugated equine estrogens) supports decreased clinical fractures at all sites in
postmenopausal women. The Women's Health Initiative study demonstrated that HT (conjugated equine estrogens with or
without a progestogen) decreased clinical fractures at the hip, vertebrae and other sites in postmenopausal women.46,78
Other Pharmacologic Choices
Raloxifene decreased vertebral fractures in RCTs.79,80,81 Reported side effects include leg cramps and vasomotor
symptoms. It is also associated with an increase in risk of venous thromboembolism.
Denosumab is a human monoclonal antibody (IgG2) that binds to receptor activator of nuclear factor-kappa B (RANK) ligand
and inhibits osteoclast formation, function and survival. It is a first-line option for the treatment of osteoporosis12 but cost
may limit its use to postmenopausal women at high risk of fracture who have failed or are unable to tolerate other
therapies.82,83
In those with severe osteoporosis or those at high risk of glucocorticoid-induced osteoporosis, teriparatide may be
considered.12,46 Teriparatide, a parathyroid hormone (PTH) analogue, is an anabolic agent that causes a steady gain in bone
density and reduces the risk of vertebral and nonvertebral (but not hip) fractures.84 It may also decrease the pain of vertebral
fractures.
Calcitonin demonstrated a moderate increase in BMD and decrease in vertebral fractures,67,85,86 and a nasal formulation
was previously available. Since 2013, Health Canada has withdrawn all nasal calcitonin spray following a review of the
benefits and safety of this formulation; a small increase in cancer risk has been noted with long-term use.87
Sodium fluoride increases bone formation by stimulating osteoblasts. A meta-analysis of 11 RCTs found that fluoride
increased spinal BMD, had little effect on hip BMD, and decreased forearm BMD.88 The relative risk of vertebral fractures
was unchanged, but the risk of nonvertebral fractures increased, possibly due to the production of bone of inferior quality.
These equivocal results, along with adverse effects such as GI distress and lower extremity pain syndrome, led to the disuse
of fluoride as a treatment for osteoporosis.
However, a meta-analysis of 25 studies re-examined the data and found that use of sodium fluoride resulted in increased
BMD of the spine and hip, with no reduction in overall fracture risk.89 In a subgroup analysis, doses of ≤20 mg fluoride
equivalents resulted in a statistically significant reduction in vertebral and nonvertebral fractures with a trend toward a
greater risk of pain syndrome with the lower dose. Additional controlled trials are needed to clarify efficacy and safety in
osteoporosis, especially using lower doses.
Many consumers are interested in using alternative therapies, such as natural health products (NHPs), to manage their
osteoporosis. A systematic review identified 45 NHPs that claimed to be of benefit for osteoporosis.90 Calcium and vitamin
D are the only NHPs recommended in the 2010 Canadian practice guidelines for the diagnosis and management of
osteoporosis.12
For the following NHPs, randomized controlled trials (RCTs) investigating bone mineral density and/or fracture rate were
identified. Results from these preliminary studies should be confirmed using larger studies conducted over several years,
using fracture rates as an outcome and considering such factors as calcium and vitamin D intake.
Dehydroepiandrosterone (DHEA) is a steroid hormone that is produced in the adrenal glands.91 While not available in
Canada, it is widely available on the Internet.
Declining DHEA levels after the mid-twenties have been linked with diseases such as obesity, cardiovascular disease and
osteoporosis; therefore, it has been proposed that DHEA may be useful in the management of these diseases.92 A
systematic review identified 2 trials of DHEA conducted in healthy adults over the age of 50,90 and 2 additional trials were
published subsequently.93,94 Results of the studies were conflicting.94,95,96 DHEA did increase BMD in the spine in a study
of men with osteoporosis.93 A dose of 50–100 mg/day was used in the studies showing beneficial effect on BMD. Adverse
effects included hair loss, deepening of the voice, insulin resistance, menstrual pattern changes and abdominal pain.97
Phytoestrogens, found in sources such as soy and red clover, are nonsteroidal plant compounds that include isoflavones,
lignans and coumestans.98 Of these, isoflavones are the most commonly used for osteoporosis. Isoflavones such as
genistein and daidzein are structurally similar to estrogens and thus can bind to estrogen receptors to produce weak
estrogenic activity. A 2006 systematic review concluded that evidence for the use of phytoestrogens in women with
osteoporosis was equivocal, with some trials demonstrating a positive effect on BMD and others showing no effect.90 Other
RCTs99,100,101,102,103,104,105,106 and a 2013 review107 also produced conflicting results. Interpretation and comparison of
these studies is complicated by different phytoestrogen formulations, content and doses used, varying study lengths and
concomitant use of calcium and vitamin D.
Studies reporting a positive effect on BMD have used products containing 54–126 mg of isoflavones.90,99,100,101,104,105
Adverse effects reported included gastrointestinal irritation, constipation, diarrhea, malaise, sleep disturbances, shortness of
breath and joint pain.90
Ipriflavone is a synthetic isoflavone derivative that may have a similar effect to that of estrogens on bone mineralization,
without having direct estrogen-like activity.108 At least 15 RCTs have examined the use of ipriflavone for the prevention of
postmenopausal bone loss. In postmenopausal women with low BMD or osteoporosis, ipriflavone maintained or increased
BMD in the distal radius109,110,111,112,113,114,115 and in the spine.114,116,117,118,119,120,121,122,123 However, a study of over
450 women reported no significant changes in BMD in the spine, hip or forearm.124 Limited data are available regarding
fracture outcome. One study115 reported a reduction in vertebral fractures in the ipriflavone group compared with placebo,
while another study124 found that the number of fractures in the treatment and control groups was not different.
Ipriflavone 200 mg TID has been used, with concomitant calcium 500–1000 mg/day. Ipriflavone was generally well tolerated;
adverse effects most commonly reported were abdominal pain, nausea, diarrhea and constipation.113,115
Vitamin K refers to several fat-soluble vitamins known as quinones. Vitamin K1 (phytonadione) is found in leafy green
vegetables, broccoli and brussels sprouts while Vitamin K2 (menaquinone) is found in meats and cheeses.125,126 Vitamin K2
is also synthesized by bacteria in the gut. Low vitamin K intake and/or serum levels have been associated with lower BMD
and fractures in people with osteoporosis.127 Two systematic reviews reported that phytonadione and menaquinone
maintained or improved BMD;90,128 one of these reviews reported that menaquinone administration reduced vertebral and
nonvertebral fracture rates.128 A 2015 systematic review of menaquinone in postmenopausal women found similar results
in that there was an improvement in vertebral BMD and possibly a reduction in fractures.129 However, there is concern about
the quality of the studies in all of these reviews and many were conducted in Asian populations, making it difficult to
generalize the results. Three studies report no effect on bone loss rates in postmenopausal women from Europe or Canada
with and without low BMD.130,131,132 One of these trials found that women taking vitamin K1 had fewer clinical fractures
compared with the placebo group.131
Vitamin K2 15 mg TID was most commonly used in the studies. It was well tolerated; GI adverse effects such as nausea and
vomiting were reported in some studies.130,131,133,134
Black cohosh has been shown to increase levels of markers of bone formation,135 but a 12-month RCT in menopausal
women found no significant effect on BMD compared with placebo.106
Table 5 lists some measures to reduce modifiable risks and how to monitor their success. In patients at risk of osteoporosis, the
expected outcome is to maintain baseline BMD. In those with demonstrated osteoporosis, the goal is to remain free of fractures
and prevent further loss of BMD.
Table 5: Monitoring Outcome of Modifiable Risk Reduction Measures

Risk Factor Recommendation Considerations
Low calcium intake Ensure diet is adequate (may refer to If supplements recommended, educate
dietitian). Add supplements to meet total patient on proper administration and
daily requirements (Table 6). prevention of constipation and drug
interactions.
Suggest appropriate dose based on salt
form of supplement (Table 4).
Risk Factor Recommendation Considerations
Sedentary lifestyle If osteoporosis is not diagnosed, Exercise should be started gradually and
recommend weight-bearing exercises tailored to the individual's health status
such as walking. If patient has significant (e.g., consider conditions such as
cardiovascular disease or osteoporosis, cardiovascular or respiratory disease).
refer to an appropriate healthcare
practitioner.
Inadequate vitamin D intake Recommend 800–1000 IU/day of vitamin If patient is taking a multivitamin, check
or >50 years of age D. for amount of vitamin D.
>1000 IU/day may be required to achieve
optimal vitamin D status; doses up to
2000 IU/day are safe.12,40
Resource Tips
Osteoporosis Canada. 1200 Eglinton Ave East, Suite 500, Toronto, Ontario M3C 1H9. Telephone: 416-696-2663, Toll-free (in
Canada only): 1-800-463-6842 (English) or 1-800-977-1778 (French). Available from: www.osteoporosis.ca.
Algorithms
12
Figure 1: Assessment of Risk for Osteoporosis
a
For further detail, refer to Papaioannou A, Morin S, Cheung AM et al. 2010 clinical practice guidelines for the diagnosis and
management of osteoporosis in Canada: summary.12
Abbreviations: BMD = bone mineral density; CAROC = Canadian Association of Radiologists and Osteoporosis Canada
Drug Table
Table 6: Calcium and Vitamin D Recommendations for Prevention and Treatment of Osteoporosisa
Drug/Costb Dosagec Adverse Effects Drug Interactions Comments
Drug Class: Nutritional Supplements

Drug/Costb Dosagec Adverse Effects Drug Interactions Comments
calcium Elemental calcium/day: When taken as a Calcium supplements Encourage

Caltrate, Men and women 19–50 y supplement: may decrease fulfillment of
generics (includes pregnant or constipation, absorption of calcium needs
breastfeeding women): flatulence, nausea; bisphosphonates, through dietary
$ rarely, hypercalcemia, ciprofloxacin, iron, intake first.
1000 mg po
hypercalciuria, renal levothyroxine, Select product
Men and women >50 y: calcification, renal tetracycline. Separate
1200 mg po based on salt
stones (at high administration by 2 h. type and amount
doses). of elemental
calcium per
tablet.
Supplement
doses
>500 mg/day
should be taken
in divided doses.
Calcium
carbonate
requires acidic
medium for best
absorption (take
with or after
meals); calcium
citrate does not.
vitamin D Adults <50 y (healthy, at low Vitamin D intoxication Mineral oil can impair Most
generics risk of deficiency):e (>50 000 IU/day)10 absorption of vitamin multivitamins
400–1000 IU/day (10–25 may result in D. and many
$ µg/day) po hypercalcemia, calcium
Increases calcium
hypercalciuria, renal absorption. supplements
Adults ≥50 y (at moderate contain vitamin
risk of vitamin D calcification, renal
stones. D. Also present in
deficiency):e fish oils (with
800–1000 IU/day (20–25 vitamin A).
µg/day) po; doses up to
2000 IU/day (50 µg/day)
may be required and are
considered safe.12,40,41
a
For further discussion of pharmacologic therapy for osteoporosis, consult the Compendium of Therapeutic Choices: Osteoporosis.
b
Cost of 30-day supply; includes drug cost only.
c
Dosage represents total daily recommended intake, from diet and supplements.
d
For comparison of elemental calcium content of various salts, see Table 4.
e
Osteoporosis Canada recommendations differ from the Health Canada Recommended Daily Allowances for vitamin D (600 IU/day for
ages 1–70 y and 800 IU/day for those >70 y).39
Legend: $ <$5
Suggested Readings
Khan A, Fortier M, Reid R et al. Osteoporosis in menopause. J Obstet Gynaecol Can 2014;36:S1-15. Available from: sogc.org/wp-
content/uploads/2014/09/JOGC-Sept2014-CPG-312_Eng_Online-Complete.pdf.
Management of osteoporosis in postmenopausal women: 2010 position statement of The North American Menopause Society.
Menopause 2010;17:25-54.
Papaioannou A, Morin S, Cheung AM et al. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis
in Canada: summary. CMAJ 2010;182:1864-73.
Whelan AM, Jurgens TM, Bowles SK. Natural health products in the prevention and treatment of osteoporosis: systematic
review of randomized controlled trials. Ann Pharmacother 2006;40:836-49.
References
Sports Injuries
Lily Lum, BScPharm, CSPI

Pathophysiology
Participation in sports activities and exercise programs is increasing as people become more health conscious.
Although associated with health benefits, sports and exercise can also cause injuries.1,2
Individuals in all age groups benefit from regular exercise when it is properly performed. In people over 45 years,
the benefits of exercise (e.g., prevention of coronary heart disease and osteoporosis) outweigh the risk of sports-
related injuries.
Based on the increasing rate of obesity, Health Canada recommends that children and teenagers participate in at
least 60 minutes of moderate- to vigorous-intensity physical activity daily.3 Participation in sports is also
encouraged. However, children and adolescents may be particularly at risk for sports injuries for several reasons.
Their bones, muscles, tendons and ligaments are still growing, making them more prone to injury. Young athletes
of similar age vary greatly in size and physical maturity; they may try to perform at levels beyond their ability to
keep up with peers. Other factors contributing to an increased risk of sports injury include improper technique,
poorly fitting protective equipment and training errors.4,5,6
Sports-related injuries are varied and can be caused by trauma, overuse of specific parts of the body such as
muscles or joints, and environmental factors.5 Acute injuries such as ligament sprains and muscle strains are
usually caused by sudden trauma and are more likely to occur in contact sports. Overuse or chronic injuries are
more subtle and are most commonly associated with sports that involve repetitive movements. The 3Fs or
“terrible toos” acronym—too fast, too far and too frequent—is often used to describe the cause of overuse
injuries.1 Some of the more common sports-related injuries such as strains and sprains, overuse injuries (e.g.,
Achilles tendinitis, bursitis, plantar fasciitis, shin splints and tennis elbow) and stress fractures are defined below.
Sports injuries can also be caused by environmental factors; e.g., heat stroke can occur during participation in
outdoor sports activities during hot temperatures.1 For further information, see Heat-Related Disorders.
Common Sports Injuries
Bursitis is the inflammation of a bursa. Bursae are tiny, fluid-containing, sac-like structures that are located
wherever there might be friction, such as between bones and the muscles and tendons near joints (Figure 1).
When they become inflamed, movement or pressure is painful. Sports-related bursitis occurs most commonly
in the elbow, knee and shoulder.
Figure 1: Knee Joint—Sagital Section

A sprain is an injury to a ligament caused by overstretching or twisting. In the ankle, a common area for
sprains, it is mainly the lateral ligaments of the joint that are involved. Symptoms include pain, swelling and
tenderness, with subsequent bruising around the injury. Symptomatically, severe sprains may be difficult to
differentiate from fractures, and an x-ray may be needed to make a firm diagnosis.1,5
A strain is an injury to a muscle and is also referred to as a torn or pulled muscle. It is usually caused by
overstretching and is characterized by pain and swelling. Muscle strains vary in severity, from damage to the
fibres with the muscle sheath left intact, to complete rupture of the muscle.1,7
Plantar fasciitis is a common condition causing heel pain; it involves inflammation of the plantar fascia, the
tough, fibrous band of tissue that runs along the sole of the foot. Inflammation usually occurs following
increased or repetitive activity such as jogging.7,8
Shin splints, also known as medial tibial stress syndrome, are inflammation of the muscles, tendons and
periosteum (bone tissue) around the tibia or shinbone. Pain occurs along the inner edge of the tibia where the
muscles attach to the bone. Shin splints are the result of repetitive activity and often occur following sudden
changes in frequency, duration or intensity of physical activity. Having flat feet or exercising with inappropriate
footwear can contribute to the development of shin splints.9
Stress fractures are tiny cracks in bones that often result from repeated, excessive impact. Athletes required
to jump repetitively (e.g., gymnasts, basketball players) often get stress fractures.7,9 They usually occur in the
feet, ankles and legs although any bone can suffer a stress fracture. An individual may not even notice when a
stress fracture initially occurs. The pain decreases with rest and increases over time, getting worse when
pressure is applied during activity. It starts progressively earlier in the workout, becoming so severe that it
prohibits exercise and persists even during rest. The area may or may not show signs of tenderness and
swelling. Stress fractures can be mistaken for shin splints because both can cause mid-calf discomfort.
However, stress fractures are more serious than shin splints, the pain lasts longer and the injury takes longer
to heal.
Tendinitis refers to acute inflammation of a tendon, the thick fibrous cord that attaches muscle to bone. Two
common examples of tendinitis are Achilles tendinitis and tennis elbow. Achilles tendinitis is inflammation of
the Achilles tendon which connects the heel to the calf muscle.9 A patient with Achilles tendinitis experiences
pain and tenderness just above the heel.
Tennis elbow, also known as lateral epicondylitis, is inflammation of the tendons attached to the
outside/lateral side of the elbow at the bony prominence of the arm bone.7 It commonly occurs during racquet
sports (such as tennis) and activities that require repetitive, one-sided movements. The patient experiences
pain and tenderness outside of the affected area, at and below the elbow joint. With repeated overuse,
degenerative micro-tears occur in the tendon, resulting in chronic epicondylosis.
While inflammation may be present with acute tendon injuries such as tendinitis, chronic injuries are more
correctly referred to as tendinosis or tendinopathy. The pathology of chronic tendinopathies is related not to
inflammation but to degenerative changes occurring in the tendon over time due to microscopic tears that fail
to heal properly.
Goals of Therapy
Provide relief of symptoms
Promote healing of the injury
Prevent re-injury or aggravation of the injury
Patient Assessment
An assessment plan for patients suffering from musculoskeletal sports injuries is illustrated in Figure 2.
Symptoms of selected non-soft tissue injuries that require immediate medical attention are described in Table 1.
7
Table 1: Selected Injuries Requiring Immediate Medical Attention
Symptoms that Warrant Immediate Medical
Injury Attention
Eye injury10 Blurred vision, loss of vision, moderate to severe eye

discomfort or pain
Head injury, e.g., concussion11 Confusion, amnesia, headache, loss of consciousness

after injury, tinnitus, drowsiness, dizziness, nausea,
vomiting, seizures, unusual eye movements or slurred
speech
Nosebleed12 Bleeding lasting longer than 20 min
Tympanic membrane perforation (ruptured Earache, partial hearing loss, slight bleeding or
eardrum)13 discharge from ear
Prevention
Proper conditioning and training prevent many sports-related injuries. Muscle pain and stiffness commonly occur
24 hours after unaccustomed intense physical activity.7 Appropriate warm-up exercises, stretching and cooling
down (gradually slowing down before stopping the exercise) should be routinely performed. Warmed-up muscles
are more pliable and less likely to tear. Stretching allows the muscles to lengthen so that they can contract and
perform more effectively. Cooling down can prevent dizziness and fainting. In a person who exercises vigorously
and suddenly stops, blood can pool in the dilated leg veins, causing dizziness and fainting. Cooling down
maintains increased circulation and helps clear the build up of lactic acid in the bloodstream.9 A gradual increase
in the intensity and duration of workouts and adequate fluid replacement are also important preventive measures.
For more information on hydration in the athlete, see Sports Nutrition.
Warning signs of impending injury include extreme fatigue, pain and lack of enthusiasm for training.1 Protective
equipment (e.g., helmet, eye protection, mouth guard, knee and wrist pads) and proper footwear are essential for
those participating in sports with a high risk of falls (e.g., in-line skating) or those requiring direct contact with
playing equipment or other players (e.g., boxing, football).5,14 Note that eyeglasses or sunglasses do not provide
adequate eye protection unless they are specifically designed for use in sporting activities.
The 4 essentials of early management of soft-tissue injuries can be remembered using the acronym RICE: Rest,
Ice, Compression, Elevation (Table 2).1,5,9
After 48 hours have passed and the initial swelling has subsided, the RICE regimen can be replaced by heat, early
mobilization, massage and/or rehabilitation with physical therapy if necessary.9
Table 2: RICE Regimen

Rest Immobilization is recommended for at least the first 24 hours to
avoid aggravation of the injury. If long-term rest is indicated, the
unaffected joint(s) should be exercised to prevent tissue atrophy
and loss of coordination. Rest for a prolonged period of time is
usually discouraged for muscle injuries.
Ice The application of cold to an injury reduces local blood flow by

constricting blood vessels, limiting the swelling. Apply cold
therapy at regular intervals, allowing a few hours between
treatments.
Compression An elasticized bandage applied to an injured area for at least the

first 24 hours can reduce swelling, support a weak joint or provide
a protective layer for wounds.
Elevation The injured area should be raised above the level of the heart to
help drain fluid and reduce swelling.
Heat vs. Cold Therapy
Should patients apply heat or cold therapy to a sports injury? As a general rule, the application of cold is the
preferred immediate treatment (first 24–48 hours) for most acute musculoskeletal injuries.15 Sources of cold
therapy include ice bags (putting crushed ice in a thick plastic bag), commercial cold gel packs or bags of
frozen peas or corn.16 Recommendations for duration and frequency of cold therapy application vary
considerably.17 The application time varies depending on the body part and comfort but usually ranges from
10–30 minutes. Apply cold at regular intervals throughout the waking hours of the day, allowing a few hours
between treatments. Areas with little body fat (bony areas such as the knee, ankle and elbow) do not tolerate
cold as well as fatty areas (such as thighs and buttocks). For bony areas, keep application time to the lower
end of the range (10 minutes); double the time when applying to fatty areas. Applying ice directly to the skin or
for too long can cause frostbite and tissue damage. A thin towel can be placed between the ice bag and skin
to prevent frostbite. Use cold therapy with caution in patients with poor circulation, such as those with
diabetes or Raynaud's disease, since these patients already have reduced local blood flow.16
Heat therapy (thermotherapy) is recommended after the first 48 hours when the swelling has subsided, and
during the chronic rehabilitative phases of the injury.18 Local heat produces analgesia by affecting free nerve
endings, decreases the incidence of painful muscle spasms by relaxing muscles, and reduces joint stiffness
by decreasing synovial fluid viscosity. Heat causes vasodilation, producing increased blood flow, which in turn
helps provide a greater local supply of nutrients, oxygen, antibodies, leukocytes and enzymes to the injured
area. Waste products from the inflammatory process are transported away with the increased blood
circulation.15 Heat may be applied for 20–30 minutes, every 2–4 hours as needed. Contraindications to the
use of local heat therapy include patients who are unconscious and those with impaired skin sensitivity, poor
circulation or open wounds.15,18 Sources of local heat therapy include hot water bottles, electric heating pads,
commercial heat packs and infrared heat lamps.15 Patients must take care to avoid burns from the use of
heat therapy products. Hot water bottles and heat packs should be wrapped with a towel or cloth for comfort
and safety. Heating pads and heat lamps should be kept on low to moderate settings.18
Therapies used to treat minor sports injuries are listed in Table 4.
For more information on pharmacologic therapy for sports injuries, consult the Compendium of Therapeutic
Choices: Sports Injuries.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments
—Analgesic Products: External Analgesics, Internal Analgesics and Antipyretics.
Oral Analgesics
Oral analgesics such as acetaminophen and NSAIDs can provide effective relief of musculoskeletal
pain.1,5,9,20 They may be useful for acute as well as chronic injuries. Advise patients to take the lowest
effective dose to relieve their pain and inflammation. Acetaminophen or NSAIDs can be given concurrently
with opioids for an additive analgesic effect. Codeine can be found in combination products for the treatment
of moderate or moderately severe pain. When taken alone in usual doses, e.g., 15–30 mg, codeine is no more
effective than ASA or acetaminophen.21 Codeine is regarded as second-line therapy for management of
sports injuries. Opioids are often drugs of choice in severe acute pain or cancer pain but have limited use for
most sports injuries. For injuries such as bone fractures, which are often extremely painful, short-term use of
acetaminophen plus codeine combinations may be warranted.20 In patients with concussion, avoid opioids so
that clouding of the patient's mental status on neurologic exam does not occur.22
Muscle Relaxants
Muscle relaxants (e.g., methocarbamol, chlorzoxazone) are generally intended to provide pain relief when
muscle spasm is a component of an acute injury. However, muscle relaxants are not routinely recommended
and are not considered first-line therapy in acute musculoskeletal injuries because of their limited
effectiveness in providing pain relief.23 Fatal hepatotoxicity has been reported with chlorzoxazone use.24
External Analgesics
External analgesics (e.g., methyl salicylate, menthol, camphor, capsaicin) are traditional remedies for the
treatment of general aches and pains. Their value is limited but they may be useful during rehabilitation as
cooling or heating rubs or as accompaniments to massage therapy.1,25 Although not often prescribed,
patients frequently purchase these products for self-treatment.20
The use of external analgesics may cause skin reactions such as a rash or blisters or rarely, serious
burns.26,27 [Evidence: SORT C] Post-marketing reports have identified some cases of severe burns that
occurred within 24–48 hours of application of products containing menthol either alone or in combination
with methyl salicylate. While there are no reports of severe burns with the use of products containing
capsaicin or methyl salicylate alone, caution is still warranted.26,27 External analgesics should not be applied
to acute injuries if there is bleeding or if the wounds are open or covered by dressings, since this can further
irritate the wound area.1 They should not be used more than 3 or 4 times a day. External analgesics should not
be used concurrently with thermotherapy devices as burns may result.28 Advise patients to stop using the
product and seek immediate medical attention if they experience pain, swelling or burning after applying an
external analgesic.27
Topical NSAIDs
Although oral NSAIDs play a well-established role in reducing pain, swelling and inflammation resulting from
sports injuries, the use of topical NSAIDs is less well entrenched.29,30,31 It is theorized that topical application
minimizes the risk of side effects associated with systemic therapy (e.g., gastrointestinal toxicity).
A meta-analysis of 86 randomized, placebo-controlled trials of transdermal NSAIDs involving 10 160 patients

concluded that topical NSAIDs are effective in relieving pain in acute and chronic conditions.32 Another meta-
analysis of 47 randomised, double-blind, active or placebo-controlled trials involving 3455 patients concluded
that topical NSAIDs were effective and safe in treating acute pain in musculoskeletal conditions.33
Topical diclofenac is available as a 1.5% solution which is indicated for osteoarthritis of the knee, and as a
1.16% or 2.32% gel indicated for the treatment of acute pain caused by injury to joints or muscles.34
Pharmacists can also extemporaneously compound topical NSAID products. Special commercial bases (e.g.,
Phlojel, Diffusimax) are available for compounding of topical NSAIDs. NSAIDs commonly incorporated into
topical formulations include diclofenac, ibuprofen and ketoprofen.35,36,37,38,39
Corticosteroid Injections
Local corticosteroid injection therapy has been used to treat painful conditions involving tendinitis despite
limited evidence of effectiveness. The number of local corticosteroid injections is usually limited to 3 per year
due to risk of atrophy, tendon rupture and osteoporosis. Corticosteroid injections should be avoided in Achilles
tendonitis, where risk of rupture is highest. Other complications of local corticosteroid injections include
temporary flare of pain and inflammation, joint infection, nerve damage and loss of skin pigmentation around
the injection site.40,41,42
Vapocoolants
Some topical anesthetic preparations, known as vapocoolants or refrigerants (e.g., ethyl chloride, Spray and
Stretch), may be useful when applied topically to control the pain associated with injuries such as sprained
ankles and bursitis. Side effects appear to be minimal although cutaneous sensitization may occur. Spray and
Stretch (pentafluoropropane 95%/tetrafluoroethane 5%) is used with the “spray and stretch” technique: the
product is sprayed onto the injured area, blocking pain impulses so the muscle can be stretched to its normal
length in a pain-free state.43,44
Table 3 provides a monitoring plan framework for soft tissue sports injuries, which should be individualized.
Table 3: Monitoring of Therapy for Soft Tissue Sports Injuries

Pain and swelling Patient: Daily Decrease in pain and If pain symptoms have not
from muscle sprain Healthcare swelling over a 14-day improved after 14 days of
or strain and overuse practitioner: After period. The injured area self-care, patient requires
injuries 14 days of therapy can gradually be used with referral to an appropriate
minimal discomfort, and healthcare practitioner for
daily activities can further assessment. If pain
eventually be performed is worsening despite drug
without pain. therapy, patient requires
immediate referral to an
appropriate healthcare
practitioner.
Resource Tips
Johns Hopkins Medicine. Health Library. Overview of sports injuries. Available from:
www.hopkinsmedicine.org/healthlibrary/conditions/adult/mens_health/overview_of_sports_injuries_85,P09509/.
U.S. National Institutes of Health. Department of Health and Human Services. National Institute of Arthritis and
Musculoskeletal and Skin Diseases (NIAMS). Handout on health: Sports injuries. November 2013. Available from:
www.niams.nih.gov/Health_Info/Sports_Injuries/default.asp.
Algorithms
Figure 2: Assessment of Patients with Musculoskeletal Sports Injuries

Abbreviations: RICE = Rest, Ice, Compression, Elevation
Drug Table
Table 4: Selected Drug Therapies for Sports Injuries

Interactions
acetaminophen 325–500 mg Q3H Hepatotoxicity Isoniazid, Increased risk

Atasol Preparations, Tylenol, PRN po associated with phenytoin may of
generics or chronic use, decrease hepatotoxicity
325–650 mg Q4H especially at high acetaminophen with chronic
$ doses. effect and alcohol intake.
PRN po
increase
or hepatotoxicity;
650–1000 mg Q6H decreased effect
PRN po of zidovudine.
Maximum dose: Acetaminophen
4 g/day has been reported
to increase INR in
warfarin-treated
patients.19 Check
INR if
acetaminophen
≥2 g/day is used
for ≥3
consecutive days.
Adjust warfarin
dosage as
required.
Interactions
acetaminophen/caffeine/codeine 1–2 tablets Q4H Hepatotoxicity Isoniazid, Use of opioids

8 mg PRN po associated with phenytoin may for a long time
Atasol with Codeine, generics Maximum: 4 g/day chronic use, decrease or in high
of acetaminophen especially at high acetaminophen doses may
$ from all sources doses. effect and cause
Dizziness, increase dependency;
drowsiness, hepatotoxicity; stopping the
nausea, vomiting, decreased effect drug abruptly
constipation. of zidovudine. may lead to
Acetaminophen withdrawal
has been reported symptoms.
to increase INR in
warfarin-treated
patients.19 Check
INR if
acetaminophen
≥2 g/day is used
for ≥3
consecutive days.
Adjust warfarin
dosage as
required.
Alcohol, CNS
depressants
(increased CNS
effects of
codeine).

Interactions
ASA 325–500 mg Q3H GI: Dyspepsia, Increased risk of Avoid use in

Aspirin, Coated Aspirin, PRN po epigastric pain, bleeding with third trimester
Entrophen, generics nausea/vomiting, anticoagulants of pregnancy.
or diarrhea, gastric (e.g., warfarin) or Avoid in
$ 325–650 mg Q4H and duodenal antiplatelet drugs children,
PRN po ulcers, GI (e.g., clopidogrel); particularly
bleeding. monitor INR more those <16 y
or
Cardiovascular: frequently and with
650–1000 mg Q6H watch for signs of
MI, stroke, heart chickenpox or
PRN po bleeding; consider
failure, fluid flu-like
retention, alternative symptoms
hypertension. therapy. because of
Nephrotoxicity May decrease possible
may occur; avoid effect of association
NSAIDs in antihypertensives. with Reye's
patients with May decrease syndrome.
severe renal renal clearance of May require
impairment (ClCr lithium; monitor discontinuation
<30 mL/min). lithium levels prior to surgery
CNS: Dizziness, when NSAID to avoid
drowsiness, added. bleeding.
headache, Increased risk of Avoid in
tinnitus, GI bleeding when patients with
confusion used with SSRIs. asthma or at
(especially in the risk of peptic
elderly); CNS ulcer.
effects may be
dose related and
respond to
decreased
dosage.
Minor or serious
skin rashes,
pruritus.
Interactions
ibuprofen 200–400 mg Abdominal Enhanced effect Caution in ASA-

Advil, Advil Liqui-Gels, Motrin, Q4–6H PRN po discomfort, of anticoagulants; sensitive
Motrin IB, generics epigastric pain, diminished effect patients.
Maximum dose for nausea, diarrhea, of diuretics,
self-care: Avoid use in
$ dizziness, antihypertensives;
1200 mg/day third trimester
drowsiness. increased serum of pregnancy.
Maximum dose: levels of digoxin,
2400 mg/day lithium. Avoid in
patients with
asthma or at
risk of peptic
ulcer.
Increased risk
of stroke or
serious CV
events at
doses ≥2400
mg/day. Doses
≥2400 mg/day
should not be
used in
patients with a
history of CV
events or with
risk factors for
CV disease.45
naproxen 250–500 mg BID Abdominal Enhanced effect Caution in ASA-

Naprosyn, generics po discomfort, of anticoagulants; sensitive
epigastric pain, diminished effect patients.
$$ nausea, diarrhea, of diuretics, Avoid use in
dizziness, antihypertensives; third trimester
drowsiness. increased serum of pregnancy.
levels of digoxin,
lithium. Avoid in
patients with
asthma or at
risk of peptic
ulcer.
naproxen sodium 220–440 mg Abdominal Enhanced effect Caution in ASA-

Aleve, generics Q8–12H PRN po discomfort, of anticoagulants; sensitive
epigastric pain, diminished effect patients.
$ Maximum dose for nausea, diarrhea, of diuretics,
self-care: Avoid use in
dizziness, antihypertensives; third trimester
440 mg/day drowsiness. increased serum of pregnancy.
levels of digoxin,
lithium. Avoid in
patients with
asthma or at
risk of peptic
ulcer.
Drug Class: NSAIDs, topical

Interactions
diclofenac diethylamine Apply TID-QID to Local irritation, Not Available as

Voltaren Emulgel, Voltaren affected area rarely, systemic recommended in 1.16% and
Emulgel Extra Strength Patient may effects combination with 2.32% gel.
require further (headache, GI other NSAIDs due Wash hands
$ irritation, to potential of
assessment if no after
improvement after bronchospasm), additive side application.
7 days hepatotoxicity. effects.
Do not apply
Plasma levels of near mucous
diclofenac are not membranes or
significant after on broken skin.
topical Do not cover
application with tight or
resulting in occlusive
decreased risk of dressing. Do
drug interactions; not place
caution with heating
medications that devices (e.g.,
may interact with hot water
oral diclofenac. bottle, heating
pad) on skin
after applying
product.
diclofenac sodium Apply TID–QID Skin dryness or Not Available as

Pennsaid, generics irritation, recommended in 1.5% lotion.
hypersensitivity. combination with Do not apply
$$$$ Serious GI other NSAIDs due near mucous
toxicity has not to potential of membranes or
been seen to additive side on broken skin.
date in clinical effects. Do not cover
trials. Plasma levels of with tight or
diclofenac are not occlusive
significant after dressing. Do
topical not place
application heating
resulting in devices (e.g.,
decreased risk of hot water
drug interactions; bottle, heating
caution with pad) on skin
medications that after applying
may interact with product.
oral diclofenac.
a
Cost of 1 week of therapy or smallest available pack size; includes drug cost only.
Abbreviations: ASA = acetylsalicylic acid; CNS = central nervous system; GI = gastrointestinal
Legend: $ <$10 $$ $10–20 $$$ $20–30 $$$$ $30–40
Suggested Readings
Harries M et al., eds. Oxford textbook of sports medicine. 2nd ed. Oxford: Oxford University Press; 1998.
Mellion MB, Putukian M, Madden CC, eds. Sports medicine secrets. 3rd ed. Philadelphia: Hanley & Belfus; 2003.
Schwellnus M, ed. The Olympic textbook of medicine in sport. Chichester, West Sussex: Wiley-Blackwell; 2008.
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2016.
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conditions/concussion/basics/symptoms/con-20019272.
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18. Pray WS. Use of local heat for minor injuries. US Pharm 1993;18:39-45.
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musculoskeletal pain in adults. Cochrane Database Syst Rev 2014;11:CD007403.
26. Health Canada. Summary Safety Review - Over-the-Counter Topical Pain Relievers Containing Menthol,
Methyl Salicylate or Capsaicin - Assessing the Risk of Serious Skin BurnsAvailable from: www.hc-
sc.gc.ca/dhp-mps/medeff/reviews-examens/topical-pain-relievers-analgesiques-topiques-eng.php.
Accessed Feb 17, 2017.
27. U.S. Food and Drug Administration. FDA Drug Safety Communication: Rare cases of serious burns with the
use of over-the-counter topical muscle and joint pain relievers. Available from:
fda.gov/Drugs/DrugSafety/ucm318858.htm. Accessed April 26, 2016.
28. Injuries to muscles, ligaments and tendons. In: Pray WS. Nonprescription product therapeutics. 1st ed.
Philadelphia: Lippincott Williams & Wilkins; 1999. p. 295-309.
Assessment of Foot Symptoms
Anne Mallin, RPh, BScPhm, PharmD, CDE

Algorithms
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15
Figure 1: Assessment of Patients with Foot Symptoms
a See Corns, Calluses, Bunions and Ingrown Toenails.

b See Fungal Nail Infections (Onychomycosis).
c See Plantar Warts.
d See Athlete's Foot.
References
1. Government of Saskatchewan. Ministry of Health. Learning package. Learning to perform a diabetes
foot screen. Available from: www.health.gov.sk.ca. Accessed July 19, 2012.
2. National Diabetes Education Program. Feet can last a lifetime: a health care provider's guide to
preventing diabetes foot problems. Available from: www.ndep.nih.gov/media/feet_kit_eng.pdf.
Accessed July 19, 2012.
3. Ford-Martin P, Blumer I. Monofilament test. Available from: www.netplaces.com/diabetes/the-
diabetic-foot/monofilament-test.htm. Accessed July 19, 2012.
4. Diabetes Centre, Royal Prince Alfred Hospital. Diabetic foot disease: an interactive guide. Foot
examination. Available from: www.sydney.edu.au/medicine/diabetes/foot/Fexam1.html. Accessed
July 19, 2012.
5. Edwards C, Stillman P. Minor illness or major disease?: responding to symptoms in the pharmacy. 3rd
ed. London: Pharmaceutical Press; 2000.
6. American Podiatric Medical Association. Warts. What are warts? Available from:
www.apma.org/Learn/FootHealth.cfm?ItemNumber=989. Accessed August 30, 2009.
7. Baxter J. Feet not just there to keep your socks on. New Zealand Pharmacy 1996 Dec:10-12.
8. Nork SE, Couglin RR. How to examine a foot and what to do with a bunion. Prim Care 1996;23:281-
97.
9. Singh D, Bentley G, Trevino SG. Callosities, corns, and calluses. BMJ 1996;312:1403-6.
10. Ontario Podiatric Medical Association. Naftolin N. Foot surgery the minimal incision approach.
Available from: www.opma.ca/press/press_details.asp?pID=18. Accessed August 30, 2009.
11. Diabetes Québec. Chapter 23. Foot care and general hygiene. In: Benhamron C, ed. Understand your
diabetes...and live a healthy life. Montreal: Rogers Media; 2008. p. 205-14.
12. eMedicineHealth. Barton ED, Chatlin BE. Corns and calluses. Available from:
www.emedicinehealth.com. Accessed September 2, 2009. Registration required.
13. American Podiatric Medical Association. Nail problems. Barometers of health. Available from:
www.apma.org. Accessed August 30, 2009.
14. American Podiatric Medical Association. Bunions. What is a bunion? Available from:
www.apma.org/Learn/FootHealth.cfm?ItemNumber=979. Accessed August 30, 2009.
15. Canadian Diabetes Association. Clinical practice guidelines. Available from: guidelines.diabetes.ca/.
Accessed July 20, 2013.
Athlete's Foot

Pathophysiology
Athlete's foot (tinea pedis) is a superficial fungal infection of the feet.1 The fungal species most
commonly involved are Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton
floccosum.2,3 Up to 70% of the population will acquire this infection at some point in their lives.4 It occurs
most commonly in teenage and adult males and is uncommon in children.1,3 Not all infected individuals
will be aware of or have symptoms of tinea pedis infection.5
Tinea pedis is transmitted either directly via contact with an infected person or indirectly through contact
with contaminated surfaces (e.g., swimming pool decks, gym change rooms).5 The infection can be
spread to other parts of the body, usually the groin or underarms, by autoinoculation (e.g., touching the
infected feet then touching other parts of the body).6
Hyperhidrosis may contribute to the presence of tinea pedis. Warm, dark, poorly ventilated, moist
environments between the toes promote fungal growth and may contribute to the presence of this
condition.7 Wearing shoes, with or without socks or hosiery, can create such environments. Other risk
factors for tinea pedis may include diabetes, immunosuppression, peripheral vascular disease, occluded
skin, poor hygiene, obesity and trauma.8 Susceptibility to the fungus varies among individuals.5
Tinea pedis may progress to ulceration if the infection extends into the dermis. Complications may
include secondary bacterial infections that may be localized or spreading, e.g., cellulitis, lymphangitis.8
Patients with diabetes or those who have had saphenous vein grafts for coronary artery bypass are
especially prone to secondary bacterial infections.1
Goals of Therapy
Resolve symptoms
Cure infection
Prevent recurrence
Prevent transmission to others
Patient Assessment
Tinea pedis may present in several ways (see Table 1). The most common presentation is chronic
interdigital infection.9,10,11,12,13
Table 1: Morphologic Variants of Tinea Pedis

Variant Lesion Typical Location Special Considerations
Morphology
Variant Lesion Typical Location Special Considerations
Morphology
Chronic Fissures, scaling Most commonly found Humidity and warmth worsen
interdigital or maceration in on the lateral toe webs, this condition. Therefore,
infection the interdigital usually between the 4th patients whose feet are prone
spaces to excessive sweating should
and 5th or 3rd and 4th
be encouraged to treat their
toes. From this area, the
hyperhidrosis along with the
infection often spreads
fungal infection.
to the instep or sole of
the foot.
Moccasin- Chronic, Generally found on both Involvement of the toenails

type papulosquamous feet, it is characterized perpetuates the infection such
infection pattern by a mild inflammation that the toenail infection must
and diffuse scaling on be treated by oral antifungal
the soles of the feet. therapy for up to 3–4 months
Often the toenails are or by surgery.5
affected.
Vesicular Small vesicles Near the instep and on Often caused by Trichophyton
the midanterior plantar mentagrophytes.
surface. Skin scaling is More prevalent in the summer.
also observed in this
area and on the toe
webs.
Acute Macerated, Sole of the foot. Hyperkeratosis and a pungent

ulcerative denuded, odour are usually present. May
disease weeping lesions be complicated by an
overgrowth of opportunistic,
gram-negative bacteria such
as Proteus or Pseudomonas
and for this reason is often
referred to as gram-negative
athlete's foot or
dermatophytosis complex.
Evidence of blisters, pruritic lesions, burning sensations, redness and inflammation in the favoured
locations or in a characteristic pattern on the feet may indicate the presence of tinea pedis. The skin may
appear macerated and an odour may be present. Severe cases may present with pain, peeling, cracking
and/or bleeding.5 See Photo, Athlete's Foot.
Photo 1: Athlete's Foot

Science Photo Library
Tinea pedis may be confused with the following conditions: disturbances of the sweat mechanism;
contact dermatitis, often due to dyes or adhesives in footwear; eczema; psoriasis or bacterial infections
(including erythrasma).9
Figure 1 depicts an approach to assessing and managing tinea pedis.
Prevention
Give patients the following instructions:5,7,9,14,15,16,17
Wash feet with soap and water every day.

Dry feet thoroughly, paying special attention to areas between the toes.
Change socks daily (more frequently if feet sweat).
Wear socks made of natural, absorbent materials or synthetic blends, e.g., acrylic, cotton,
polypropylene, wool. Individuals with hyperhidrosis should avoid socks that are made of nylon.
Avoid tight-fitting footwear.
Allow shoes to dry completely before being worn again. This may take 2–3 days and it may be
necessary to alternate pairs of shoes on different days.
Do not go barefoot in public places (e.g., swimming pool decks or gym change rooms)—wear foot
protection (e.g., sandals, pool shoes).
Do not share personal items such as towels.
Antiperspirants or absorbent powders (e.g., talcum or aluminum chloride) can be applied to the feet to
decrease sweating.
In addition to the above measures, individuals with a history of tinea pedis may regularly apply a dusting
of antifungal powder such as tolnaftate once or twice daily on their feet to prevent further recurrences.18
To prevent coagulation of powder and moisture buildup, antifungal powder should not be placed in
shoes.18,19
Individuals with tinea pedis should follow the guidelines described under Prevention as adjuncts to
pharmacologic treatment. Follow these measures to eliminate moisture and reduce recurrence.14
Absorption of moisture and decreasing moisture buildup can be achieved by separating the toes using
cotton balls.
Ailments—Foot Care Products: Athlete's Foot.
Treatment of the skin with a topical antifungal agent (e.g., ciclopirox 1%, clotrimazole 1%, ketoconazole
2%, miconazole 2%, terbinafine 1%) twice daily is the mainstay of therapy (see Table 2). Treatment
typically continues for up to 4 weeks, including 1–2 weeks after the lesions have disappeared, to prevent
recurrences.20
Topical terbinafine 1% may have a slightly higher cure rate compared with other topical antifungals.21
Inflamed infections may benefit from adding a topical anti-inflammatory such as betamethasone or
hydrocortisone; some antifungal and topical corticosteroid combinations exist commercially (e.g.,
clioquinol 3%/hydrocortisone 1%, clioquinol 3%/flumethasone pivalate 0.02%, clotrimazole
1%/betamethasone dipropionate 0.05%). If signs and symptoms persist beyond 6 weeks, consider
referral to a foot care specialist. The main causes of treatment failure are incorrect diagnosis and
inadequate treatment.
Oral fluconazole, itraconazole or terbinafine may be indicated for tinea pedis infections that are resistant
to topical treatment.22 Toenail involvement requires oral treatment.
There is no evidence that tea tree oil is effective in the treatment of tinea pedis, and if used it should not
be applied to open lesions.21
The selection of dosage form is based on individual preference. Generally, ointments remain in contact
with the affected area for a longer period of time than creams; however, there is the danger of creating an
occlusive barrier, which promotes skin maceration and retards wound healing. Powders may be either
nonmedicated or medicated and are also absorbent. Solutions, sprays or foams applied directly to the
skin should be allowed to air dry.
Rash during therapy may indicate an allergic reaction to the product. The patient should discontinue use
of the product and consult with an appropriate health-care practitioner.
If no improvement is seen within 2 weeks, or if symptoms have not completely disappeared within 6
weeks of treatment, refer the patient to a foot care specialist.

Advise patient to:
Finish the recommended course of treatment to prevent recurrence, even though symptoms may
improve before the treatment course is complete.5
Dry the feet last after showering or bathing and use a clean towel every day, to prevent
autoinoculation.
Prevent transmission to others by not going barefoot around the home or in public areas until the
infection is cured.
Resources
Mayo Clinic. Patient Care & Health Information. Diseases and Conditions. Athlete's foot. Available from:
www.mayoclinic.org/diseases-conditions/athletes-foot/symptoms-causes/syc-20353841.
U.S. National Library of Medicine; National Institutes of Health. MedlinePlus. Athlete's foot. Available
from: www.nlm.nih.gov/medlineplus/ency/article/000875.htm.
Algorithms
Figure 1: Assessment and Treatment of Patients with Athlete's Foot
Abbreviations: PVD = peripheral vascular disease.
Drug Table
Table 2: Pharmacologic Therapy for Athlete's Foot
Drug/Costa Dosage Adverse Effects Comments
Drug Class: Antifungal/Corticosteroid Combinations
clioquinol Apply to Local skin irritation or Also exhibits antibacterial and

3%/flumethasone affected hypersensitivity anti-inflammatory properties.
pivalate 0.02% areas (burning, erythema, Particularly useful when
Locacorten BID × 4 pruritus, rash, stinging). inflammation is a prominent
Vioform wk feature. Available as cream.
$$$$
clioquinol Apply to Local skin irritation or Also exhibits antibacterial and

3%/hydrocortisone affected hypersensitivity anti-inflammatory properties.
1% areas (burning, erythema, Particularly useful when
Vioform HC BID × 4 pruritus, rash, stinging). inflammation is a prominent
wk feature. Available as cream.
$$$
clotrimazole Apply to Local skin irritation or Particularly useful when

1%/betamethasone affected hypersensitivity inflammation is a prominent
dipropionate 0.05% areas (burning, erythema, feature. Available as cream.
Lotriderm BID × 4 pruritus, rash, stinging).
wk
$$
Drug Class: Antifungals, Allylamine
terbinafine 1% Apply to Local skin irritation or Patients treated with shorter

Lamisil affected hypersensitivity durations of therapy (1–2 wk)
areas (burning, erythema, continue to improve during the
$$ BID × 4 pruritus, rash, stinging). 2- to 4-wk period after therapy
wk has been completed. Available
as cream, spray.
terbinafine oral 250 mg GI irritation, headache, Considered for tinea pedis

Terbinafine, other once skin irritation. infections that are resistant to
generics daily PO topical treatment.
× 2 wk
$$$$
Drug Class: Antifungals, Azole
clotrimazole 1% Apply to Local skin irritation or Available as cream.

Canesten Topical, affected hypersensitivity
generics areas (burning, erythema,
BID × 4 pruritus, rash, stinging).
$ wk
fluconazole 150 mg No clinically meaningful Considered for tinea pedis

Diflucan One, once adverse effects at this infections that are resistant to
CanesOral, weekly dosage regimen. topical treatment.
generics PO × 2–
6 wk
$/wk
itraconazole 200 mg Abdominal pain, Considered for tinea pedis

Sporanox BID PO constipation, diarrhea, infections that are resistant to
Capsules, × 1 wk dyspepsia, flatulence, topical treatment.
Sporanox Oral headache, nausea,
Solution, generics pruritus, skin rash,
worsening heart failure
$60 symptoms.
ketoconazole 2% Apply to Local skin irritation or Available as cream.

Ketoderm affected hypersensitivity
areas (burning, erythema,
$ BID × 4 pruritus, rash, stinging).
wk
miconazole 2% Apply to Local skin irritation or Available as cream, spray

Micatin, Monistat affected hypersensitivity powder. Avoid inhaling powder
areas (burning, erythema, preparations.
wk
Drug Class: Antifungals, Hydroxypyridone
ciclopirox 1% Apply to Local skin irritation or Available as cream, lotion.

Loprox affected hypersensitivity
areas (burning, erythema,
$$ BID × 4 pruritus, rash, stinging).
wk
Drug Class: Antifungals, Miscellaneous
tolnaftate 1% Apply to Local skin irritation or Available as cream, aerosol,

Tinactin, others affected hypersensitivity topical powder, spray. Avoid
areas (burning, erythema, inhaling powder preparations.
wk
undecylenic acid Apply to Local skin irritation or Available as cream, liquid,

Fungicure, Flexitol affected hypersensitivity ointment, powder, aerosol
Antifungal, others areas (burning, erythema, spray. Avoid inhaling powder
BID × 4 pruritus, rash, stinging). preparations.
$ wk
a Cost of specified duration of treatment for oral dose or smallest available pack size unless otherwise specified;
includes drug cost only.
Abbreviations: GI = gastrointestinal
Legend: $ <$10 $$ $10–20 $$$ $20–30 $$$$ $30–40
Suggested Readings
Andrews MD, Burns M. Common tinea infections in children. Am Fam Physician 2008;77:1415-20.
Gupta AK, Cooper EA. Update in antifungal therapy of dermatophytosis. Mycopathologia 2008;166:353-
67.
Weinstein A, Berman B. Topical treatment of common superficial tinea infections. Am Fam Physician
2002;65:2095-102.
References
1. Fitzpatrick TB, Johnson RA, Wolff K et al. Fungal infections of the skin and hair. In: Fitzpatrick TB
et al., eds. Color atlas and synopsis of clinical dermatology: common and serious diseases. 4th ed.
New York: McGraw-Hill Medical; 2001. p. 684-725.
2. Rinaldi MG. Dermatophytosis: epidemiological and microbiological update. J Am Acad Dermatol
2000;43:S120-4.
3. Antifungal agents for common paediatric infections. Paediatr Child Health 2000;5:477-91.
4. Zuber TJ, Baddam K. Superficial fungal infection of the skin. Where and how it appears help
determine therapy. Postgrad Med 2001;109:117-20,123-6, 131-2.
5. MedicineNet. Athlete's foot. Available from: www.medicinenet.com. Accessed January 5, 2018.
6. American Podiatric Medical Association. Athlete's foot. What is athlete's foot? Available from:
www.apma.org/Patients/FootHealth.cfm?ItemNumber=978. Accessed January 5, 2018.
7. Diabetes Québec. Chapter 23. Foot care and general hygiene. In: Benhamron C, ed. Understand
your diabetes...and live a healthy life. Montreal: Rogers Media; 2008. p. 205-14.
8. Al Hasan M, Fitzgerald SM, Saoudian M et al. Dermatology for the practicing allergist: Tinea pedis
and its complications. Clin Mol Allergy 2004;2:5.
9. Crawford F, Hart R, Bell-Syer SE et al. Extracts from “Clinical evidence”: Athlete's foot and fungally
infected toenails. BMJ 2001;322:288-9.
10. Beers M, Berkow R, eds. The Merck manual of diagnosis and therapy. 17th ed. Whitehouse
Station: Merck Research Laboratories; 1999.
11. American Diabetes Association clinical practice recommendations. Foot care in patients with
diabetes mellitus. Diabetes Care 1997;20:S31.
12. May I see the pharmacist? Aus Pharm 1997;16:223.
13. Bedinghaus JM, Niedfeldt MW. Over-the-counter foot remedies. Am Fam Physician 2001;64:791-
6.
14. Donaldson R. Athlete's foot. Can Pharm J 1998 Apr:33.
15. Canadian Podiatric Medical Association. Common conditions and ailments: athlete's foot.
Available from: www.podiatrycanada.org. Accessed January 5, 2018.
16. eMedicineHealth from WebMD. Athlete's foot. Available from: www.emedicinehealth.com.
Accessed January 5, 2018. Registration required.
17. Pickup TL, Adams BB. Prevalence of tinea pedis in professional and college soccer players
versus non-athletes. Clin J Sport Med 2007;17:52-4.
18. Smith EB, Dickson JE, Knox JM. Tolnaftate powder in prophylaxis of tinea pedis. South Med J
1974;67:776-8.
19. Field LA, Adams BB. Tinea pedis in athletes. Int J Dermatol 2008;47:485-92.
20. Weinstein A, Berman B. Topical treatment of common superficial tinea infections. Am Fam
Physician 2002;65:2095-102.
21. Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot.
Cochrane Database Syst Rev 2007;(3):CD001434.
22. Bell-Syer SE, Khan SM, Torgerson DJ. Oral treatments for fungal infections of the skin of the foot.
Cochrane Database Syst Rev 2012;(10):CD003584.

Athlete's Foot
Athlete's Foot—What You Need to Know
What is athlete's foot?
Athlete's foot is an infection of the skin on the feet. It is caused by a fungus. Anyone can get athlete's foot—not just athletes!
What are the signs of athlete's foot?
If a person has athlete's foot, the soles of the feet may be red and itchy. The skin between the smaller toes may be scaly or
peeling. Athlete's foot may be confused with other kinds of skin infections.
How do you treat athlete's foot?
To get rid of athlete's foot, you must kill the fungus that causes it. There are many different products to treat athlete's foot,
including creams, ointments, gels, lotions, powders and sprays. Most products are available without a prescription. Your
pharmacist can help you choose the product that is best for you.
Usually, the product is applied to the affected areas twice daily for at least 4 weeks. If nonprescription products do not get rid
of the athlete's foot, you may benefit from medication that you take by mouth to treat the infection.
See a foot care specialist if:
You do not see any improvement in your symptoms within 2 weeks

Your symptoms are not completely gone within 6 weeks
Hints to help you get rid of athlete's foot
Wash your feet daily in lukewarm water with a mild soap that does not contain deodorant.
Do not soak your feet longer than 10 minutes.
Rinse your feet well.
Dry your feet carefully, especially between the toes. Use a soft towel to reduce irritation. If possible, use a clean
towel each time you wash your feet.
Use a nonabsorbent bath mat that can be disinfected.
Change your shoes and socks daily.
Wear socks made of natural, absorbent materials or synthetic blends, such as acrylic, cotton, polypropylene or
wool.
Wear shoes that provide good ventilation. Leather or canvas shoes allow moisture (from perspiration) to escape
so your feet stay drier.
Do not go barefoot in places where you could catch athlete's foot or spread it to other people. Wear sandals in
pool areas or shower areas.
Do not share personal items such as towels.
Foot Care Products: Athlete's Foot
Product Manufacturer Dosage Active Ingredients

Form
Allpresan Pro Footcare Neubourg Skin foam tolnaftate 1%
Mousse Care
Canesten Topical Bayer Consumer cream clotrimazole 1%
Clotrimazole Cream various cream clotrimazole 1%
Dr. Scholl's Athlete's Foot Schering-Plough powder tolnaftate 1%

Powder
Dr. Scholl's Athlete's Foot Schering-Plough aerosol tolnaftate1%

Spray Powder
Emtrix Paladin Labs liquid lactic acid 10%

propylene glycol 66.4%
urea 20%
Flexitol Antifungal Cream LaCorium cream tolnaftate 1%
Flexitol Antifungal Liquid LaCorium liquid undecylenic acid 25%
Footworks Antifungal Foot Avon liquid tolnaftate 1%

Spray
Fungicure Antifungal Alva-Amco liquid undecylenic acid 25%

Intensive Liquid Pharmacal
Fungicure Antifungal Liquid Alva-Amco liquid undecylenic acid 10%

Pharmacal
Fungicure Gel Maximum Alva-Amco gel undecylenic acid 25%

Strength Pharmacal
Fungi-NailLiquid Aurium Pharma liquid undecylenic acid 25%
Fungi-NailOintment Aurium Pharma ointment undecylenic acid 25%
Fungi-NailPen Aurium Pharma liquid undecylenic acid 25%
Micatin Derm Cream Wellspring cream miconazole nitrate 2%

Pharmaceutical
Micatin Spray Wellspring aerosol miconazole nitrate 2%

Pharmaceutical
Form
Monistat Derm Cream Insight cream miconazole nitrate 2%
Pharmaceuticals
Odor-Eaters Athlete's Foot & Combe aerosol tolnaftate 1%

Sneaker Spray Powder
Thursday Plantation Abundance gel tea tree oil 5%

Antifungal Gel Naturally
Tinactin Aerosol Powder Schering-Plough aerosol tolnaftate 1%
Tinactin Cream Schering-Plough cream tolnaftate 1%
Tinactin Powder Schering-Plough powder tolnaftate 1%
Tolnaftate Cream various cream tolnaftate 1%
Corns, Calluses, Bunions and Ingrown Toenails

Pathophysiology
Corns and Calluses
Corns (clavus, heloma) and calluses (tyloma) occur when keratinization becomes overactive in an
attempt to protect the foot from excessive friction or pressure from the skin rubbing against bony
areas of the foot.1,2,3
Poorly fitting footwear can lead to the presence of corns and calluses by placing pressure on bony
areas or causing excess friction. Calluses may also form as a result of weight gain, abnormal gait or
foot structure (e.g., bunion, hammertoe). Corns and calluses are not contagious and are observed in
most age groups.
Bunions
A bunion (hallux valgus) is a deformed great toe joint (first metatarsophalangeal or MTP joint), where
the joint is angled outward with the great toe angled toward the other toes (see Figure 1).3,4 Bursitis
with signs and symptoms of pain, swelling and erythema may also be present. Factors causing
predisposition include arthritis, which may cause further damage to the joint space, or the foot's bone
structure, which may be inherited. When the joint of the little toe is involved it is called a bunionette.
Heredity of foot type, abnormal gait, constant abnormal joint motion and pressure and the wearing of
tight-fitting shoes may all contribute to the presence of bunions. They are 10 times more common in
women than men, possibly due to the wearing of narrow, pointed-toe shoes.
Ingrown Toenails
It was previously thought that ingrown toenails (onychocryptosis) have nail edges that curve into the
soft tissue surrounding the toenails, usually that of the great toes. Another more recent approach
suggests that overgrowth of the tissue surrounding the nail bed is responsible for the impact
between the nail edge and the tissue.5,6,7 When the soft tissue and the nail edge impact on each
other, the nail edge becomes irritated and often appears red and inflamed. Heredity, improper
trimming of toenails, trauma and toe crowding may all contribute to the development of ingrown
toenails. The incidence in males is double that of females and is highest between 10 and 30 years of
age.
Figure 1: Bunion
Goals of Therapy
Relieve symptoms
Remove the cause of the lesion so that it may regress (or not progress in the case of bunions)
Prevent recurrences
Patient Assessment
When possible, inspect the patient's feet and footwear. Note the presence of lesions, changes in skin
colour, sensation, texture or temperature, swelling, pain, rashes, signs of gangrene (dryness, moisture,
gas) or obvious abnormalities in foot structure such as bunions or hammertoes.1,3,8,9,10 Check the fit of
the shoe (see Proper Shoe Fit), paying special attention to its length and the width and depth of the toe
box.
Corns and Calluses
Corns (helomae) appear as tough layers of compacted, dead skin cells, which may have a central
cone (radix) over the bony area or spur. The radix is triangular in shape and points inward. The
affected area may also be yellowed.
Hard corns favour the areas over the 5th toe joint and on the soles of the feet, while soft corns are
found between the toes, especially between the 4th and 5th. Corns are rarely found under a toenail
(see Photo, Corns). Hard corns may be confused with plantar warts (verrucae plantaris). However,
when the top layer of skin cells is removed, pinpoint bleeding is observed with plantar warts. In
addition, skin ridges pass through corns but around plantar warts.
Photo 1: Corns
Jolyot/Science Photo Library
A soft corn is essentially a hard corn that has absorbed moisture from sweat, becoming macerated.
Soft corns are often confused with athlete's foot. However, soft corns are often quite painful, whereas
athlete's foot tends to be pruritic and usually not painful. Corns may also become inflamed or
infected.
Calluses (tylomae) have a similar appearance to corns and tend to be well defined. They are of
relatively even thickness and do not have a radix. Calluses tend to occur on the soles of the feet,
especially on the heel or ball of the foot.
A burning sensation and pain when the affected area is compressed may indicate the presence of a
corn or callus.
Bunions
A bunion looks like a bump on the outside edge of the affected foot. Its distinctive appearance along
with swelling, pain and redness are characteristic of this foot condition. Individuals with a bunion
should receive early treatment to stabilize the joint and reduce arthritic development.
Figure 3 depicts the assessment and management of corns, calluses and bunions.
Ingrown Toenails
Patients usually experience pain generated by the penetration and irritation of the soft tissue
surrounding the toenail. Tenderness of the immediate area, erythema and abscess formation may
also be present.
Ailments—Foot-Care Products: Insoles; Pads, Moleskins and Toe Protection Products.
Corns, Calluses and Bunions
Identifying and removing the cause of the lesion is the most important step in the treatment of corns,
calluses or bunions. In addition to self-examination of the feet, persons with specific medical
conditions such as diabetes should be examined by a health practitioner with foot-care expertise at
each office visit and at least annually. Individuals deemed to be at higher risk should have their feet
examined more often.11 The most common intervention is a change in footwear and this is often the
only treatment required (see Proper Shoe Fit).12,13,14 Orthotic devices may be inserted into footwear
to provide arch support and to distribute body weight more evenly so that excess pressure is
removed from the affected area of the foot.
Devices such as cushions, felt pads and latex foam can be used to protect a corn, callus or bunion.12
A variety of shapes and sizes are available to accommodate the various lesions. Custom pads can be
constructed from moleskin or lambswool. Placing lambswool between the toes affected by a soft
corn decreases the pain.
Débridement of a corn or callus using a pumice stone can be performed after soaking the area in
warm water for about 10 minutes, with or without sodium bicarbonate (baking soda). Castor, olive,
sesame seed or wheat germ oils can be applied to the affected area to soften corns or calluses. The
abrasive action of walking on wet sand can assist in the removal of dead skin from the soles of the
feet. A foot file (e.g., emery board) can be used on a dry foot. Persons with specific medical
conditions such as diabetes should not self-treat for corns or calluses.11 Excising corns with
electrosurgery may result in superior pain relief at 6 months compared with standard sharp
débridement with a scalpel or scissors.15
When nonsurgical interventions have failed to adequately relieve pain and discomfort, surgery is
indicated. The choice of surgical options for bunions is based on a variety of factors.16
Ingrown Toenails
Polyurethane foam toecaps are useful as protective devices for ingrown toenails. Determining
optimum shoe fit and altering footwear to remove pressure points may prevent recurrences of
ingrown toenails (see Proper Shoe Fit below). To prevent toenails from becoming ingrown, trim them
straight across and do not round the corners. The corners of nails should project beyond the skin
(see Figure 2). Instruments such as rounded-end scissors and nail clippers should be handled with
care and individuals with impaired vision or poor dexterity should avoid their use altogether to avoid
foot injuries. A foot-care specialist may excise infected tissue or chemically destroy the nail matrix
for effective treatment of ingrown toenails.17,18
Figure 2: Trimming of Ingrown Toenails
Proper Shoe Fit
Proper shoe fit is especially important in women as they are 4 times more likely than men to develop
foot problems.14 Shoe choices should be appropriate for the type of activity (e.g., hiking boots for
hikers). If possible, shoes should be purchased at the end of the day when feet are most swollen due
to gravity pulling fluid in the body down to the feet.14 Since one foot is often larger than the other,
both shoes should be tried on with stockings. When standing, there should be enough room for the
toes to spread in the toe box. The individual should walk around to check for tightness or rubbing
within the shoes. If the individual plans to wear orthotics in the shoe, these should be worn during the
fitting. Allow one-half inch (1.25 cm) between the end of the shoe and the longest toe so the toes do
not bump into the shoe during ambulation. The first MTP joint (located at the base of the great toe)
should be in the widest part of the toe box. The heel should fit snugly and the foot should not slip up
and down during ambulation. New shoes should be worn approximately one-half hour daily at first to
gradually break them in.
The following are desirable characteristics of footwear:
Fastened with buckles, laces or velcro (slip-on shoes should be avoided due to possible slipping
of the foot inside the shoe) and made from canvas or leather (to allow for flexibility)
Wide toe box and not pointed to prevent toe crowding
Heels lower than 1.5 inches (3.75 cm) to prevent forward pressure and crowding of the toes
Lightweight and flexible under the balls of the feet with good shock-absorbing, cushioned soles,
e.g., rubber, crepe
Prevention
Minor Ailments—Skin Care Products: Dermatitis and Dry Skin.
Maintaining moisture balance and removing dead skin cells help prevent formation of corns and
calluses.19 Neutral, unscented, moisturizing topical products without acid content may be applied to
dry skin on the feet (except between the toes, as it may cause excessive softening) to prevent the
formation of corns and calluses or to soften existing lesions. Hydrating products with humectants
soften the skin (e.g., Nivea, Glaxal Base). Anti-dehydration products form a film on the skin to reduce
moisture evaporation (e.g., Lubriderm lotion, Cetaphil, Keri lotion, Vaseline Intensive Care lotion,
silicone cream). Hydrating products containing keratolytic and exfoliating ingredients should be
applied only to the top layer of skin (stratum corneum) and not to broken skin. These products assist
with the removal of dead skin cells (e.g., Uremol 10, Dermal Therapy with urea concentrations 10%,
15%, 20% or 25%). Urea has the potential to cause burning or tingling sensations when applied to dry
or cracked skin.
Corns and Calluses
Minor Ailments—Foot Care Products: Corns, Calluses and Warts.
Salicylic acid in concentrations of up to 40% is available for the self-treatment of corns and
calluses.12,19 Although various concentrations of salicylic acid appear to be successful in treating
corns and calluses, there is no strong evidence for their effectiveness in treating these foot
conditions. Salicylic acid concentrations of 12–40% may be indicated if the cause of the lesion is not
easily corrected or if the patient is too uncomfortable to wait for the lesion to regress once the cause
has been removed. Some products are described in Table 1.
Plasters and pads tend to adhere to the lesion better than liquid dosage forms. Salicylic acid will
damage normal skin, so it is important that it not be applied outside the edge of the corn or callus.
When liquid preparations are used, the normal skin surrounding the lesion can be protected with an
occlusive application of petrolatum or a mechanical occlusion, such as a bandage with an aperture
for application of the product. Liquid collodion vehicles should not be used by the elderly due to risk
of poor vision, or by children due to the potential for poisoning by ingestion or inhalation.
Bunions
Minor Ailments—Analgesic Products: Internal Analgesics and Antipyretics.
Use of ice packs and analgesics such as acetaminophen or nonsteroidal anti-inflammatory drugs
(NSAIDs) may be considered, to reduce pain and swelling of an inflamed bunion.3,4 If
nonpharmacologic approaches or analgesics are inadequate, intra-articular corticosteroids may be
considered for pain reduction.
Ingrown Toenails
Minor Ailments—Analgesic Products: Internal Analgesics and Antipyretics; Skin Care Products: First
Aid.
Refer patients with ingrown toenails to a foot-care specialist. In the interim, general measures can be
employed to control infections or relieve pain and inflammation.5 Protection from infection can be
achieved with the use of topical antibiotic creams or ointments. Topical antiseptics (e.g., alcohol 70%
swabs, povidone-iodine and chlorhexidine gluconate 0.05% dressings) or footbath solutions (e.g., 15
mL of povidone-iodine or chlorhexidine gluconate 2% or 4% in 1 litre of lukewarm boiled water) can
be used to disinfect the skin. Local anesthetics (e.g., benzocaine 20% solution) or hypertonic saline
or magnesium sulfate (Epsom salts) footbaths 3 or 4 times daily may be useful in reducing pain.
Footbaths are typically used for no longer than 10 minutes.
The treatment of choice is partial surgical removal of the nail border with or without destruction of
the nail bed matrix.5 After surgery the area is kept dry overnight with the foot elevated. This is
generally followed with daily foot soaks and antibiotic ointment application starting 48 hours after
the procedure. Oral analgesics (e.g., acetaminophen or NSAIDs) may be considered, if appropriate.
Depending upon the presence and extent of infection, systemic antibiotics may be used; however, the
available evidence suggests that oral antibiotics taken before or after surgery do not decrease
healing time. Further assessment is required if signs of infection develop or persist (e.g., erythema,
swelling, purulent discharge).
Corns and Calluses
Clinical improvement should be evident within 10–14 days after initiating treatment with a salicylic
acid–containing product. Advise the patient to inspect the affected area at least twice weekly until
healing is complete. If no improvement is noted, refer to a foot-care specialist. If normal skin
surrounding the lesion is damaged by incorrect use of salicylic acid preparations, recommend
discontinuation of the product until the normal skin is healed. If the lesion becomes red or inflamed
or drains purulent material, refer to a foot-care specialist.

Advise the patient regarding:
Foot inspection for lesions

Strategies for preventing future occurrences, including proper fit of footwear
Nonpharmacologic treatment
Proper use of protective devices
Pharmacologic treatment, including proper use of a salicylic acid product, if indicated
When to seek the attention of a foot-care specialist
Algorithms
Figure 3: Assessment of Patients with Corns, Calluses and Bunions
Drug Table
Table 1: Topical Treatment of Corns and Calluses

Effects
Drug Class: Keratolytics
salicylic acid Apply daily or BID PRN for up Excessive Available as a liquid in a
12–17.6% to 14 days burning collodion-like solution.
liquid or Apply a small amount to the
Compound irritation. clean and dry area of the lesion.
W, Soluver, Not to be used by individuals
others with diabetes, peripheral
vascular disease or impaired
$
circulation.
Highly flammable—store at
room temperature away from
fire or flame.
Avoid inhaling fumes or direct
eye contact.
Do not apply to broken, infected
or irritated skin.
Wash hands thoroughly after
application.
Effects
salicylic acid Apply medicated plaster and Excessive Available as pads or plasters for
12–40% leave in place × 2 days; burning external use.
pads and repeat Q2 days for up to 14 or Trim pad or plaster to fit the size
plasters days irritation. and shape of the clean and dry
Compound area of the lesion.
W, Soluver Not to be used by individuals
Plus, others with diabetes, peripheral
vascular disease or impaired
$
circulation.
Do not apply to broken, infected
or irritated skin.
Wash hands thoroughly after
application.
a Cost of smallest available pack size; includes drug cost only.
Legend: $ <$10
Suggested Readings
Bedinghaus JM, Niedfeldt MW. Over-the-counter foot remedies. Am Fam Physician 2001;64:791-6.
Heidelbaugh JJ, Lee H. Management of the ingrown toenail. Am Fam Physician 2009;79:303-8.
References
1. Singh D, Bentley G, Trevino SG. Callosities, corns, and calluses. BMJ 1996;312:1403-6.
2. Knight AL. Selected disorders of the skin. In: Taylor RB, ed. Family medicine: principles and
practice. 4th ed. New York: Springer-Verlag; 1994. p. 952-3.
3. Silfverskiold JP. Common foot problems. Relieving the pain of bunions, keratoses, corns, and
calluses. Postgrad Med 1991;89:183-8.
4. American Podiatric Medical Association. Bunions. What is a bunion? Available from:
www.apma.org/Patients/FootHealth.cfm?ItemNumber=979. Accessed January 28, 2013.
5. Heidelbaugh JJ, Lee H. Management of the ingrown toenail. Am Fam Physician 2009;79:303-8.
6. Overgrown toeskin. Available from: www.overgrowntoeskin.ca. Accessed March 25, 2015.
7. Chapeskie H. Ingrown toenail or overgrown toe skin?: Alternative treatment for onychocryptosis.
Can Fam Physician 2008;54:1561-2.
8. Nork SE, Coughlin RR. How to examine a foot and what to do with a bunion. Prim Care
1996;23:281-97.
9. Canadian Podiatric Medical Association. Foot health. Available from:
www.podiatrycanada.org/foot-health/. Accessed February 2, 2016.
10. Edwards C, Stillman P. Minor illness or major disease?: the clinical pharmacist in the community.
3rd ed. London: Pharmaceutical Press; 2000.
11. Canadian Diabetes Association. Clinical practice guidelines 2013. Available from:
guidelines.diabetes.ca. Accessed March 25, 2015.
12. Bedinghaus JM, Niedfeldt MW. Over-the-counter foot remedies. Am Fam Physician 2001;64:791-
6.
13. Richards RN. Calluses, corns and shoes. Semin Dermatol 1991;10:112-4.
14. Ontario Podiatric Medical Association. Koven N, Miltchin H, Wong-Sing J. How to buy the best
shoes. Available from: go.epublish4me.com/ebook/ebook?id=10058746#/14. Accessed
February 2, 2016.
15. Bevans JS, Bosson G. A comparison of electrosurgery and sharp debridement in the treatment of
chronic neurovascular, neurofibrous and hard corns. A pragmatic randomised controlled trial.
Foot (Edinb) 2010;20:12-7.
16. Joseph TN, Mroczek KJ. Decision making in the treatment of hallux valgus. Bull NYU Hosp Jt Dis
2007;65:19-23.
17. Eekhof JA, Van Wijk B, Knuistingh Neven A et al. Interventions for ingrowing toenails. Cochrane
18. Eekhof JA, Neven AK, Gransjean SP et al. Minor derm ailments: how good is the evidence for
common treatments? J Fam Pract 2009;58:E2.
19. Barton ED, Chatlin BE. Corns and calluses. Available from: www.emedicinehealth.com. Accessed
January 28, 2013.

Corns and Calluses
Bunions
Corns and Calluses—What You Need to Know
What are corns and calluses?
Corns and calluses look like thick, tough layers of skin. Corns are usually found on or between the toes. Calluses, which are
found on the soles of the feet, are caused by friction or pressure from the skin rubbing against the bones of the feet. The area
may look red or be painful.
How do you treat corns and calluses?
Make sure your shoes fit properly. They should not crowd your toes nor allow your foot to slip around in the heel.
There should be a space of at least one-half inch (1.25 cm) between the tip of your longest toe and the front of
the shoe.
Apply a felt pad with a hole in the centre over a corn to reduce pressure on the area.
Put a latex foam insole into your shoe or apply moleskin to the affected area to cushion and protect your foot.
You can use a pumice stone or callus file (e.g., emery board) to remove dry skin buildup. Use the pumice stone
on wet skin and the file on dry skin.
Never cut a corn or callus yourself with any instrument.
Nonprescription products are available to help remove the corn or callus. Talk to your pharmacist to see if one is right for you.
Bunions—What You Need to Know
What is a bunion?
A bunion looks like a bump on the outside edge of the foot. It is caused by a deformed great toe joint that causes the great
toe to point towards the other toes of the foot.
If you have foot pain, see your health-care provider.
How do you treat a bunion?
It is important to relieve pressure on the bunion to reduce pain and to keep it from getting worse.
Avoid wearing narrow-fitting shoes or shoes with heels over 1.5 inches (3.75 cm) high. You will need a wider
shoe to relieve pressure and rubbing.
Use felt pads (e.g., moleskin) or latex foam to cushion the bunion.
If the bunion becomes painful or swollen, apply an ice pack for 10 minutes. You can use the ice pack several
times during the day.
Nonprescription pain relievers such as acetaminophen, ibuprofen or naproxen may help with pain and swelling.
Talk to your pharmacist for help in choosing a pain reliever.
If ice packs and pain relievers do not work, a foot-care specialist may inject cortisone into the joint.
Some people need a surgical procedure to correct the problem.
Plantar Warts

Pathophysiology
Warts are benign tumors caused by many human papilloma virus (HPV) types including 1, 2, 4 and 57.1
Warts found on the soles of the feet are called plantar warts (verrucae plantaris). HPV infects the upper
epidermis and causes squamous epithelial cells to proliferate.2 The infection exists only in humans and
is transmitted via contact with another lesion or contaminated surfaces.3 Infection usually occurs
through small cuts or microabrasions.4 The infection may become clinically evident through the
appearance of warts, or it may remain latent or cause subclinical infection where the change in the skin
surface is not evident to the naked eye.1 The incubation period between initial infection and the
appearance of warty lesions varies from 1 to 8 months.5 Up to 30% of warts spontaneously regress
within 6 months due to cell-mediated immunity, but those that do not regress in that time period
frequently proliferate. Regression within 6 months is more likely in children.
Plantar warts may occur singly or in clusters (mosaic warts). They are uncommon in infancy and are
most common in children and young adults. The peak incidence of warts occurs between 12 and 16
years of age.
Risk factors for plantar warts include immunosuppression and exposure to environments where the virus
may contaminate surfaces (e.g., swimming pool decks, communal showers).
Goals of Therapy
Alleviate or prevent pain due to the wart
Eradicate lesions and prevent their proliferation
Prevent recurrence
Prevent transmission to others
Patient Assessment
Most warts are harmless. However, depending upon their size, number and location, they can cause pain
and may be a source of embarrassment to the patient.2,4,6,7
Plantar warts are often symptomless, producing pain only upon pressure. This pain is usually greater on
lateral compression (when the lesion is pinched from the sides) than with direct pressure. They are
usually rough, firm hyperkeratoses that, unlike common warts on the hands, grow inwards due to
pressure from walking. Warts are usually skin coloured but may often be grey or brown. Thrombosed
capillaries may appear as black dots in the centre of the lesion, or these may only be evident as pinpoint
bleeding that occurs if the lesion is débrided. Unlike corns, skin striations tend to run around the wart, as
opposed to through it. Plantar warts tend to arise on the heel or the ball of the foot where
microabrasions are more likely to occur and allow inoculation. See Photo Plantar Warts.
Photo 1: Plantar Warts

Dr. P. Marazzi/Science Photo Library
Figure 1 depicts the assessment and treatment of patients with plantar warts.
Prevention
Give patients the following instructions:4,8,9
Avoid walking barefoot in public places and wear foot protection (e.g., sandals, pool shoes) when in
areas where transmission may be more common (e.g., swimming pool decks, gym showers,
dormitories)
Change shoes and socks every day
Keep feet clean and dry
Avoid touching warts on someone else or on another part of your body
Do not share socks or footwear
Use waterproof tape during treatment to prevent transmission of the virus to others.
Hyperthermic therapy, immunotherapy, cryosurgery using liquid nitrogen, CO2 laser, curettage and
radiosurgery using electrodes have been used to treat plantar warts with varying success.9,10
Hyperthermic treatment involves soaking the affected area in hot water for 90 minutes daily for many
months.9 CO2 laser therapy involves the vapourization of tissue and is thought to be the most effective
form of treatment.11 Clear duct tape is not effective.12 Conflicting data suggest that cryotherapy with
liquid nitrogen may not be more effective than placebo.12
Based on the cryosurgery method using liquid nitrogen, a medical device containing dimethylether and
propane freezes the wart so that it ceases to host the virus and causes a blister to form under it,
resulting in the wart falling off approximately 10 days after treatment.9 Efficacy in inducing cell necrosis
may be lower than that achieved with liquid nitrogen as lower cell temperatures are attained with liquid
nitrogen (−196°C) than with dimethylether and propane (−57°C).3 Its role in self-care is yet to be
determined.
Ailments—Foot Care Products: Corns, Calluses and Warts.
Chemicals applied topically over the long term can trigger an inflammatory response to stimulate the
body's immune system to attack the virus. These chemicals may also have the ability to destroy infected
tissue. Generally, improvement is evident within 1–2 weeks after the initiation of treatment.9,10 When
home therapy results in increased pain, swelling, bleeding or fever, or improvement is not evident in
several weeks, refer the patient to a healthcare practitioner experienced in the treatment of plantar warts
for further assessment.8,9
Topical application of chemicals such as 2-hydroxybenzoic acid, 2-hydroxypropanoic acid, 5-fluorouracil,

cantharidin, dichloroacetic acid, formalin, glutaraldehyde, podophyllin, pyrogallic acid, salicylic acid,
trichloroacetic acid and vitamin A, which may be keratolytic, drying or cauterizing, has been used to treat
plantar warts.
Table 1 describes some preparations available for self-treatment of plantar warts. The ingredient
common to all products is salicylic acid in concentrations of 5–40%. The advantages of salicylic acid
and other topical chemicals include control over the amount of disability and discomfort and a low risk
of scarring. Disadvantages include the length of treatment, which is often several months. Application of
liquid preparations that dry on the wart allows for treatment of the affected area only, whereas more
solid dosage forms (e.g., pastes, ointments) may spread to normal skin upon weight bearing.13 Topical
salicylic acid is safe and effective for the treatment of warts at all body sites and may be as effective as
cryotherapy.12,14,15
Vitamin A has been used orally and topically to treat patients with multiple lesions;9,13 there are no
randomized controlled trials to support this approach.
A topical preparation containing cantharidin 1%, podophyllin 2% or 5% and salicylic acid 30% is a
vesicant that must be applied by a foot care specialist. After application, the lesion is kept occluded for
3–7 days. During this time a blister forms and the plantar wart becomes necrotic. Treatment with or
without curettage may need to be repeated. In some patients, pain may interfere with ambulation.
Analgesics (e.g., acetaminophen, ASA, ibuprofen or naproxen sodium) may be considered for pain
management.
Cure rates with any method of treatment are 60–70% and up to 60% of plantar warts go into
spontaneous remission. Untreated plantar warts can easily spread to other sites.9,16 Cure rates are
higher in children and immunocompetent hosts and when the duration of infection is short. They are
lower if the wart has failed to respond to any other type of treatment. Mosaic warts are more resistant to
treatment than single lesions.3,15 Even when treatment appears to have been successful, warts may
recur. This may be due to failure to remove tissue in which the virus has caused only latent or subclinical
infection.
Check with the patient every 4 weeks to see if any improvement has been noted and to encourage
adherence. If the lesion persists after 12 weeks of self-treatment, or if skin is damaged and becomes
painful or inflamed or drains purulent material, refer the patient to a foot care specialist.

covering the wart to prevent transmission to other people

not removing the plantar wart themselves
using the chosen preparation properly
preventing and managing adverse effects of treatment
when to contact a foot care specialist.
Resource Tips
Mayo Clinic. Diseases and Conditions. Plantar warts. Available from:
www.mayoclinic.com/health/plantar-warts/ds00509.
U.S. National Library of Medicine; National Institutes of Health. MedlinePlus. Warts. Available from:
www.nlm.nih.gov/medlineplus/ency/article/000885.htm.
Algorithms
Figure 1: Assessment and Treatment of Plantar Warts
Drug Table
Table 1: Products for Self-treatment of Plantar Warts
Drug Class: Keratolytic Agents

salicylic acid 5–17% in Gel/liquid: Apply 1 drop Excessive Available as gel,

collodion-like solution; daily or BID burning/irritation. liquid in collodion-
15% in a karaya gum, Pads/plasters: Apply like solution, pads,
glycol plaster; 12–40% once daily plasters and
in other plasters ointment.
Compound W, Soluver, Apply salicylic acid
products after Apply to clean and
others dry area of lesion;
showering or soaking
the affected area at for external use
$
bedtime; repeat daily up only.
to 12 wk Trim pads/plasters
to fit lesion area.
Not to be used by
individuals with
diabetes,
peripheral vascular
disease or
impaired
circulation.
Liquid form highly
flammable—store
at room
temperature away
from fire or flame.
Avoid inhaling
fumes of liquid
form.
Avoid direct
contact with the
eyes; flush with
water × 15 min if
contact with the
eye(s) occurs.
Do not use on
birthmarks, moles,
genital/facial/hairy
warts or mucous
membranes or if
the affected area
becomes red,
irritated or
inflamed.
Wash hands
thoroughly after
application.
Legend: $ <$10
Suggested Readings
Lichon V, Khachemoune A. Plantar warts: a focus on treatment modalities. Dermatol Nurs 2007;19:372-5.
References
1. Drake LA, Ceilley RI, Cornelison RL et al. Guidelines of care for warts: human papillomavirus.
Committee on Guidelines of Care. J Am Acad Dermatol 1995;32:98-103.
2. Verbov J. How to manage warts. Arch Dis Child 1999;80:97-9.
3. Sterling JC, Handfield-Jones S, Hudson PM. Guidelines for the management of cutaneous warts.
Br J Dermatol 2001;144:4-11.
4. Landsman MJ, Mancuso JE, Abramow SP. Diagnosis, pathophysiology, and treatment of plantar
verruca. Clin Podiatr Med Surg 1996;13:55-71.
5. Bolton RA. Nongenital warts: classification and treatment options. Am Fam Physician
1991;43:2049-56.
6. Baxter J. Feet not just there to keep your socks on. New Zealand Pharmacy 1996 Dec:10-2.
7. Popovich NG, Newton GD. Minor foot disorders. In: Young LL, Engle JP, Berardi RR et al., eds.
Handbook of nonprescription drugs. 12th ed. Washington: American Pharmaceutical Association;
2000. p. 781-818.
8. Canadian Podiatric Medical Association. Common conditions and ailments. Available from:
www.podiatrycanada.org. Accessed February 25, 2016.
9. eMedicineHealth from WebMD. Cole GW. Plantar warts. Reviewed July 2015. Available from:
www.emedicinehealth.com. Registration required. Accessed February 25, 2016.
10. Ontario Podiatric Medical Association. Goldberg R. The war on warts. Available from:
go.epublish4me.com/ebook/ebook?id=10058745#/2. Accessed May 3, 2016.
11. Ontario Podiatric Medical Association. Nesbitt L. Laser foot surgery. Available from:
go.epublish4me.com/ebook/ebook?id=10058746#/2. Accessed May 3, 2016.
12. Kwok CS, Gibbs S, Bennett C et al. Topical treatments for cutaneous warts. Cochrane Database
Syst Rev 2012;(9):CD001781.
13. Lemont H. Exploring current approaches to plantar warts. Podiatry Today 2006;19:68-74.
Available from: www.podiatrytoday.com/article/6440. Accessed February 25, 2016.
14. Eekhof JA, Neven AK, Gransjean SP et al. Minor derm ailments: how good is the evidence for
common treatments? J Fam Pract 2009;58:E2.
15. Gibbs S, Harvey I Local treatments for cutaneous warts. Cochrane Database Syst Rev 2006;
(3):CD001781.
16. Remedy’s Health Communities. Lunsford JM. Plantar warts. Modified October 2015. Available
from: www.healthcommunities.com/plantar-warts/overview-of-plantar-warts.shtml. Accessed
February 25, 2016.

Plantar Warts
Plantar Warts—What You Need to Know
What is a plantar wart?
A plantar wart is a wart on the bottom of the foot. Plantar warts are caused by a viral infection of the skin. They are usually
harmless but can be painful.
Where does the virus come from?
You catch the virus by touching someone else's wart or touching a surface that has the virus on it. The virus is often found on
swimming pool decks and in gym showers or dormitories.
What can you do to prevent plantar warts?
Do not go barefoot in public places. Wear sandals or pool shoes when necessary.
Change your shoes and socks every day.
Keep your feet clean and dry.
Avoid touching another person's warts or another part of your body after touching a wart.
Do not share socks or footwear.
Use waterproof tape during treatment.
How are plantar warts treated?
A number of wart removal products are available. Most contain a type of acid that, over time, eats away the wart. It can take
up to 12 weeks or several months for the wart to go away. People who have diabetes, poor circulation or weak immune
systems should not use these products without professional advice. Talk to a healthcare provider with footcare experience
about the treatment that is best for you.
How to use wart removal products safely:
Soak the wart in warm water for 5 minutes, then gently rub away loose tissue with a pumice stone, emery board
file or rough washcloth.
Liquid preparations: Protect healthy skin around the wart by applying a thin layer of white petrolatum such as
Vaseline. Apply the liquid to the wart 1 drop at a time until the affected area is covered. Let it air dry, then cover
with waterproof adhesive tape. If the preparation touches healthy skin, immediately wash it off with soap and
water.
Stick-on plaster: Trim it to the size and shape of the wart before putting it on.
Disk with a pad: Choose a disk that is the right size, apply it, then cover with the pad supplied.
Do not apply any product to skin that is red, broken or swollen.
Do not use the product more often than recommended in the directions.
Do not use any product for more than 12 weeks.
When should you see your healthcare provider?
See your healthcare provider if the wart is not gone after 12 weeks of treatment or if the healthy skin has been damaged.
Foot Care Products: Corns, Calluses and Warts

Form
Canthacur Paladin liquid cantharidin 0.7%
Cantharone Dormer liquid cantharidin 0.7%
Compound W Dual Power Pads Medtech pad salicylic acid 40%
Compound W Freeze Off Wart Medtech liquid cryotherapy mixture: dimethyl ether
Removal System and propane (DMEP)
Compound W Gel Medtech gel salicylic acid 17%
Compound W Liquid Medtech liquid salicylic acid 17%
Compound W One Step Pads Medtech pad salicylic acid 40%
Compound W Pads for Kids Medtech pad salicylic acid 40%
Compound W Plantar Pads Medtech pad salicylic acid 40%
Compound W Plus Liquid Medtech liquid salicylic acid 30%
Freezone Liquid Medtech liquid salicylic acid 17.6%
Freezone One Step Corn & Medtech pad salicylic acid 40%
Callus Remover
Scholl 2 Drop Corn & Callus Schering- liquid salicylic acid 17%
Remedy Plough
Scholl Clear Away Liquid Wart Schering- liquid salicylic acid 17%
Remover Plough
Scholl Clear Away Plantar Wart Schering- plaster salicylic acid 40%
Remover Plough
Scholl Clear Away Wart Schering- plaster salicylic acid 40%

Remover Plough
Scholl Freeze Away Schering- liquid cryotherapy mixture: dimethyl ether

Plough and propane (DMEP)
Scholl One Step Callus Remover Schering- plaster salicylic acid 40%
Plough
Form
Scholl One Step Corn Remover Schering- plaster salicylic acid 40%
Plough
Scholl One Step Plantar Wart Schering- pad salicylic acid 40%
Remover Plough
Scholl One Step Wart Remover Schering- plaster salicylic acid 40%
Plough
Scholl Ultra Thin Corn Removers Schering- plaster salicylic acid 40%
Plough
Soluver Dermtek liquid salicylic acid 20%
Soluver Plus Dermtek liquid salicylic acid 27%
Verrukill Wart Remover ANB Canada liquid cryotherapy mixture: dimethyl ether
and propane (DMEP)
Wart Freeze Remover various liquid cryotherapy mixture: dimethyl ether

and propane (DMEP)
Wart Removal Gel various gel salicylic acid 17%
Wart Remover Liquid various liquid salicylic acid 17%
WartFreeze Hands & Feet Aurium liquid cryotherapy mixture: dimethyl ether
and propane (DMEP)
Wartner for Kids Aurium liquid cryotherapy mixture: dimethyl ether

and propane (DMEP)
Wartner Original Aurium liquid cryotherapy mixture: dimethyl ether

and propane (DMEP)
Wartner Plantar Warts Aurium liquid cryotherapy mixture: dimethyl ether

and propane (DMEP)
A Summary of Common Skin Conditions
Penny F. Miller, BSc(Pharm), MA

a,1,2,3,4,5,6
Table 1: Summary of Common Skin Conditions
Body Area Condition Signs and Symptoms Location(s) Management
Scalp Tinea capitis Bald patch(es) with Scalp (usually in Patient requires
See Fungal Skin round, scaling lesions; children) assessment and/or
Infections itchy. May be inflamed treatment by appropriate
boggy nodule healthcare practitioner.
Head lice White spots (nits) Scalp, especially Recommend self-care.

See Parasitic clinging to base of sides and
Skin Infections: hair that are not easily posterior aspects
Lice and Scabies removed; itchy (commonly in
children)
Psoriasis Silver scales on an Posterior scalp Patient requires

See Psoriasis elevated assessment by
erythematous base appropriate healthcare
(plaques). Pinpoint practitioner for
bleeding spots are diagnosis; self-care
evident when scales measures may be
are scratched off. appropriate depending
Symmetric on severity at diagnosis.
distribution is
common
Dandruff Diffuse, white flakes Scalp Recommend self-care.

See Dandruff and without redness;
Seborrheic mildly itchy
Dermatitis
Shingles Unilateral, painful, Scalp, forehead Patient requires

(Herpes zoster) grouped blisters with and face assessment and/or
eventual crusts. The treatment by appropriate
See Viral Skin lesions are arranged healthcare practitioner
Rashes in a linear immediately, due to risk
(dermatomal) pattern of eye involvement.
along a sensory nerve
Seborrheic Mildly red patches Scalp, eyebrows Recommend self-care;

dermatitis with yellowish, greasy and nasolabial patient requires
See Dandruff and scale. Ill-defined folds, eyelid assessment and/or
Seborrheic borders margins treatment by appropriate
Dermatitis healthcare practitioner if
severe.
Trunk Shingles Painful vesicles in a Dermatomal Patient requires

(Herpes zoster) unilateral dermatomal distribution, linear assessment and/or
distribution with from back to treatment by appropriate
See Viral Skin eventual crusting chest or abdomen healthcare practitioner
Rashes promptly as treatment
should be initiated <72 h
from onset of rash.
Tinea corporis Round, red, scaly Trunk, limbs Recommend self-care.

See Fungal Skin patches with well-
Infections defined, raised edges;
central clearing and
itchy
Phototoxic Exaggerated sunburn Sun-exposed Recommend self-care

photosensitivity (may be blistered if areas unless severe; patients
reaction severe) then require
See Prevention management by
and Treatment of appropriate healthcare
Sun-induced Skin practitioner for
Damage reassessment of drug
therapy if necessary.
Photoallergic Red, itchy papules Any skin area Recommend self-care.

photosensitivity with no sharp borders
reaction
Pityriasis Light-coloured Chest, back Recommend self-care.

versicolor patches on tanned
See Fungal Skin skin or darker-
Infections coloured patches on
untanned skin; fine
scale
Face Acne Comedones, papules, Face Recommend self-care if

See Acne pustules and cysts. mild; patient requires
Commonly in assessment and/or
adolescents treatment by appropriate
healthcare practitioner if
moderate-severe.
Acne rosacea Papules, pustules (no Face Patient requires

See Acne comedones); flushing assessment and/or
in blush areas treatment by appropriate
Perioral Discrete, red or flesh- Around mouth Patient requires

dermatitis coloured papules and and nasolabial assessment and/or
See Acne pustules. May be folds treatment by appropriate
pruritic and burning healthcare practitioner.
Folliculitis Small red pustules Bearded (hairy) Recommend self-care.

See Bacterial surrounding hair areas
Skin Infections: follicles
Impetigo,
Furuncles and
Carbuncles and
Acne
Furuncles Painful, red, raised Bearded (hairy) Recommend self-care if

See Bacterial lump (nodules) with areas, back of only a few, small lesions
Skin Infections: pus-filled centre neck are present; otherwise
Impetigo, around hair follicle patient requires
Furuncles and assessment and/or
Carbuncles treatment by appropriate
Carbuncles Large, painful, red, Bearded (hairy) Patient requires

See Bacterial raised nodules with areas, back of assessment and/or
Skin Infections: pus-filled centre neck treatment by appropriate
Impetigo, around multiple hair healthcare practitioner.
Furuncles and follicles; fever,
Carbuncles malaise, adenopathy
Cold sores Tingling sensation Lips Recommend self-care;

(Herpes simplex) progressing to tiny, patient requires
See Cold Sores painful, grouped assessment and/or
(Herpes Labialis) blisters, then crusts treatment by appropriate
healthcare practitioner if
genital involvement or
immunocompromised.
Impetigo Weeping vesicles with Around nose and Recommend self-care if

See Bacterial honey-coloured mouth (usually) a few small lesions;
Skin Infections: crusts. Erythema otherwise, patient
Impetigo, surrounds lesion. requires assessment
Furuncles and Adenopathy is and/or treatment by
Carbuncles common appropriate healthcare
practitioner.
Phototoxic Exaggerated sunburn Sun-exposed skin Recommend self-care

photosensitivity areas unless severe; patients
reaction then require
See Prevention management by
and Treatment of appropriate healthcare
Sun-induced Skin practitioner for
Damage reassessment of drug
therapy if necessary.
Photoallergic Red, itchy vesicles Any skin area Recommend self-care

photosensitivity unless severe; patient
reaction requires management
by appropriate
healthcare practitioner
for reassessment of
drug therapy if
necessary.
Contact Localized, itchy, red Any skin area in Recommend self-care

dermatitis vesicles contact with unless severe.
See Atopic, allergen
Contact, and
Stasis Dermatitis
Atopic dermatitis Red, itchy, weeping Infants: face Patient requires

See Atopic, vesicles; eventually (cheeks) assessment and/or
Contact, and see chronic changes— Adolescents and treatment by appropriate
Stasis Dermatitis lichenified dry skin young adults: healthcare practitioner.
(thickened, sides of neck
accentuated skin
markings)
Limbs Contact Localized, itchy red Hands, wrists or Recommend self-care

dermatitis vesicles any area exposed unless severe.
See Atopic, to contact
Contact, and allergen
Stasis Dermatitis
Common warts Skin-coloured, well- Hands, fingers, Recommend self-care.

See Viral Skin defined, small, round, around nails
Infections: rough-surfaced
Common and papules. May see
Flat Warts black dots on surface
Flat warts Multiple, smooth, flat Hands Patient requires

See Viral Skin or slightly elevated assessment and/or
Infections: reddish papules treatment by appropriate
Common and healthcare practitioner.
Flat Warts
Psoriasis Red plaques with a Knees, elbows Patient requires

See Psoriasis silvery scale which assessment by
reveal bleeding points appropriate healthcare
when removed. practitioner for
diagnosis; self-care
measures may be
appropriate depending
on severity at diagnosis.
Scabies Red lesions, possibly Finger webs and Patient requires

See Parasitic with thin grey lines; wrists; armpits assessment by
Skin Infections: itching that increases appropriate healthcare
Lice and Scabies at night practitioner for
diagnosis; recommend
self-care for
management.
Atopic dermatitis Red, itchy vesicles Extensor areas in Patient requires

See Atopic, infants; flexural assessment and/or
Contact, and area in treatment by appropriate
Stasis Dermatitis adolescents and healthcare practitioner.
adults
Cellulitis Red, hot, hard, painful Often at site of Patient requires

skin area with trauma immediate assessment
systemic symptoms and/or treatment by
of fever and malaise appropriate healthcare
practitioner.
Stasis dermatitis Red, itchy vesicles, Lower legs, Patient requires

See Atopic, edema followed by ankles (in older assessment and/or
Contact, and brownish, scaly, adults) treatment by appropriate
Stasis Dermatitis thickened skin; pain healthcare practitioner.
Nails Distal and lateral Thickened; Fungal infection Patient requires

subungual discoloured yellow- starts in the nail assessment and/or
onychomycosis brown; debris bed just under the treatment by appropriate
(Tinea unguium) collection under the tip of the nail healthcare practitioner.
nail; separation of nail (distal end) and
See Fungal Nail plate from nail bed spreads
Infections proximally
(Onychomycosis) towards cuticle
White superficial Powdery white Fungal infection Patient requires

onychomycosis patches on nail starts as patches assessment and/or
(Tinea unguium) surface. May spread on top of nail treatment by appropriate
to involve entire nail plate healthcare practitioner.
See Fungal Nail which becomes
Infections roughened and
(Onychomycosis) crumbly
Paronychia Swelling and redness Involves nail folds Patient requires

(Candida of nail fold. Cuticle and nails in assessment by
onychomycosis) may detach from nail persons with appropriate healthcare
plate excessive water practitioner for
See Fungal Nail exposure diagnosis; recommend
Infections self-care once
(Onychomycosis) diagnosed if mild case.
Genitals Pubic lice Crab lice and eggs Genital area; Recommend self-care.
See Parasitic detectable; very itchy other hairy areas
Skin Infections:
Lice and Scabies
Candidiasis Red, moist rash with Skin folds such Recommend self-care.
See Fungal Skin irregular edges and as groin (gluteal
Infections satellite lesions fold), under
(papules outside the breasts, axillae
edge of the rash);
itchy and sore
Tinea cruris Red-brown, bilateral, Inner aspect of Recommend self-care.

See Fungal Skin well-demarcated rash; thighs and pubic
Infections itchy area; scrotum and
penis is spared in
males. Often
associated with
jock itch tinea pedis
Psoriasis Bilateral, red, sharply Intergluteal folds Patient requires

See Psoriasis demarcated plaques (groin), axillae assessment by
(scales are absent in appropriate healthcare
intertriginous areas) practitioner for
diagnosis; recommend
self-care for
management depending
on severity at diagnosis.
a Only the most common signs and symptoms, presentations and locations are listed; not inclusive. Systemic symptoms
accompanying these rashes or any conditions not responding to self-care management should be referred to an appropriate
healthcare practitioner. Viral exanthems and foot conditions not included in this table.
References
1. Edwards C, Stillman P. Minor illness or major disease?: responding to symptoms in the pharmacy. 3rd
ed. London: Pharmaceutical Press; 2000.
2. Marks JG, Miller JJ, eds. Lookingbill and Marks’ principles of dermatology. 5th ed. Philadelphia:
Saunders/Elsevier; 2013.
3. Goldsmith LA, Katz SI, Gilchrest BA et al., eds. Fitzpatrick's dermatology in general medicine. 8th ed.
New York: McGraw-Hill; 2012.
4. Schalock PC, Hsu JT, Arndt, KA, eds. Lippincott's primary care dermatology. Philadelphia: Wolters
Kluwer/Lippincott Williams & Wilkins; 2011.
5. Habif TP. Clinical dermatology: a color guide to diagnosis and therapy. 6th ed. St. Louis: Elsevier; 2016.
6. Habif TP, Campbell JL, Chapman MS et al. Skin disease: diagnosis and treatment. 3rd ed. New York:
Acne
Debra Sibbald, BScPhm, ACPR, MA (Adult Education), PhD (Education)

Date of Revision: October 2016
Pathophysiology
Acne vulgaris, or acne, is a common, multifactorial, androgen-dependent skin disorder, which can vary in
presentation and be difficult to treat. Although perceived as benign and self-limiting, acne is associated with
important physical and psychological problems. Acne is present in about 80% of people between the ages of
11 and 30. Although primarily a disease of adolescence (prevalence in this age group ranges from 50–95%), it
is not limited to teenagers, can begin as early as the neonatal period, and is present in 20–30% of individuals
aged 20–40. The intensity and duration vary for each individual, and in most cases acne becomes less active
as adolescence ends. It is severe in males in about 15% of cases, which is tenfold greater than females. Acne
has an earlier onset and is more persistent in females (12% of women vs. 3% of men in those aged 25–58
years); periodic premenstrual flares may continue until menopause.1,2 Genetic factors have been recognized:
there is a high concordance among identical twins and a tendency towards severe acne in patients with a
family history of acne.3
Four primary pathogenic factors interact to produce acne lesions:
1. Increased sebum production by the sebaceous gland

2. Propionibacterium acnes follicular colonization (and bacterial lipolysis of sebum triglycerides to free fatty
acids)
3. Release of inflammatory mediators
4. Alteration in the inflammatory process
Acne usually begins in the prepubertal period when the adrenal glands mature, and progresses as androgen
production and sebaceous gland activity increase with gonad development.
There has been an improvement in the understanding of acne development that suggests acne is a disease
that involves both innate and adaptive immune systems and inflammatory events.3 Receptors that regulate
sebaceous lipid metabolism work in concert with those regulating epidermal growth and differentiation. Acne
is the result of an obstructed sebaceous follicle, called a microcomedone. Patients with seborrhea and acne
have a significantly greater number of lobules per sebaceous gland compared with unaffected individuals.
Sebaceous glands (Figure 1) increase in size and activity in response to circulating androgens. Sterol
regulatory element-binding proteins mediate the increase in sebaceous lipid formation. The composition of
sebum is altered, with a reduction in linoleic acid. The pooling of sebum in the follicle provides ideal substrate
conditions for proliferation of the anaerobic bacterium P. acnes, which produces a lipase that can hydrolyze
sebum triglycerides into free fatty acids. This generates a T-cell response, which results in inflammation.
Inflammatory responses occur prior to the hyperproliferation of keratinocytes.4,5
The development of comedones is independent of the colonization with P. acnes and occurs due to the growth
change of keratinocytes. The infra-infundibulum increases its keratinization of cells leading to
hypercornification and development of the microcomedone, the primary lesion of both noninflammatory and
inflammatory acne.6 Cells aggregate in an expanding mass, which forms a dense keratinous plug. Sebum,
produced in increasing amounts by the active gland, becomes trapped behind the keratin plug and solidifies,
contributing to open or closed comedone formation. The sebaceous gland also acts as an endocrine organ in
response to changes in androgens and other hormones. Oxidized squalene can stimulate the
hyperproliferative behaviour of keratinocytes. The closed comedone, or whitehead, is the first clinically visible
lesion of acne and takes approximately 5 months to develop. The closed comedone is almost completely
obstructed to drainage and has a tendency to rupture.7,8,9
Figure 1: The Skin

As the plug extends to the upper canal and dilates its opening, an open comedone, or blackhead, is formed.
Its dark colour is not due to dirt but to either oxidized lipid and melanin or to the impacted mass of horny
cells. The cylindrically shaped, open comedone is very stable and may persist for a long time as soluble
substances and liquid sebum escape more easily. Acne that is characterized by open and closed comedones
is called noninflammatory acne.
Recruitment of polymorphs into the follicle during the inflammatory process, and release of P. acnes-
generated chemokines, leads to pus formation. The pus eventually bursts on the surface with resolution of the
inflammation, or into the dermis. P. acnes also produces enzymes which increase the permeability of the
follicular wall, causing it to rupture, releasing keratin, hair, lipids and irritating free fatty acids into the dermis.
Several different types of inflammatory lesions may form. A superficial aggregation of neutrophils forms a
pustule, a raised white lesion filled with pus, usually less than 5 mm in diameter. Superficial pustules usually
resolve within a few days without scarring. A deeper, dermal, inflammatory infiltration will produce a nodule,
the most severe variant of acne. They are warm, tender, firm lesions, with a diameter of 5 mm or greater. They
may be suppurative or hemorrhagic within the dermis, may involve adjacent follicles and sometimes extend
down to fat. Nodules and deep lesions may result in scarring. Suppurative nodules can be called cysts
because they resemble inflamed epidermal cysts. The cascade of the pathogenesis of acne is shown in
Figure 2.
Hyperpigmentation and scarring are 2 sequelae of acne (see Treating Sequelae of Acne). A time delay of up to
3 years between acne onset and adequate treatment correlates to degrees of scarring, and emphasizes the
need for earlier therapy.10,11
Figure 2: Pathogenesis of Acne Cascade

Goals of Therapy
Alleviate symptoms by reducing the number and severity of lesions
Slow the progression of signs and symptoms
Limit disease duration and recurrence
Prevent long-term disfigurement associated with scarring and hyperpigmentation
Avoid psychological suffering
Patient Assessment
Information on the assessment of patients with acne can also be found in Figure 3.
Clinical Presentation
Acne can be noninflammatory or inflammatory. Noninflammatory acne is characterized by open and

closed comedones. Inflammatory acne is traditionally characterized by papulopustular and/or nodular
lesions. Lesions can occur anywhere on the body apart from the palms and soles, and are usually located
on the face, back, neck and chest, and may extend to buttocks or extremities. Often resolution of these
lesions leaves erythematous or pigmented macules that can persist for months or longer, especially in
dark-skinned individuals.
Existing grading systems are very difficult to compare. Two commonly used grading systems are detailed
in Table 1.
3,12
Table 1: Severity Grading of Acne Lesions
FDA Investigator Global Assessment European Union Guidelines Clinical Classification
(2005) (2012)
Type 1 Almost clear: Rare Comedonal acne

noninflammatory lesions (NIL)
with no more than 1 papule
Type 2 Mild: Some NIL but no more Mild-moderate papulopustular acne

than a few papules or pustules
Type 3 Moderate: Many NIL, some Severe papulopustular acne, moderate nodular
inflammatory lesions (IL), no acne
more than 1 nodule
Type 4 Severe: Up to many NIL and IL, Severe nodular acne, conglobate acne
but no more than a few nodular
lesions
Risk and Aggravating Factors
Acne can be caused or exacerbated by a variety of factors. One in 5 infants ≤3 months of age may develop
papules, pustules and, less commonly, closed or open comedones, primarily on the cheeks, due to
placental transfer of maternal androgens (neonatal acne). The acne subsides within a few months with
regular maturation. Boys are affected more often than girls because of a transient increase in testosterone
secretion during the third and fourth month of intrauterine life. Malassezia species (a yeast) may be
involved in pathogenesis.2 Resolution occurs without therapy.13 Infants with neonatal acne may have
more severe teenage acne compared with their peers.2
Acneiform eruptions may be provoked by hormonal changes such as androgenic and antiestrogenic
progestogens, found in oral contraceptives. Hormonal changes in pregnancy may also change the
appearance of acne. Seventy percent of females may complain of premenstrual flares. The pilosebaceous
duct opening is significantly smaller between days 15 and 20 of the menstrual cycle, causing duct
obstruction which impedes sebum flow and keratin hydration.14,15 Endocrine-related conditions (e.g.,
irregular menses, hirsutism, alopecia) may contribute to formation of acne lesions.
The application of some topical agents may promote the formation of acne (contact acne). This can be
due to the use of cosmetics or topical medications or to occupational hazards. Comedone formation
through mechanically occluded follicles (pomade acne) may occur with the use of oil-based scalp
preparations on the forehead and temples, oily lubricants (such as baby oil) in infants and children and the
application of topical tar products. Tar folliculitis can be minimized by applying the tar in the direction the
hair grows out at the skin surface, leaving the angle beneath the hair free of tar to allow secretion of duct
contents. In some postadolescent women, acne can be caused or made worse by the liberal use of oily
cosmetics (cosmetic acne). This commonly occurs in a perioral distribution with a clear zone around the
lips; acne due to application of hairspray may develop around the hair margins. Closed comedones,
papules, pustules and nodules may be induced by contact with occupational materials including
acnegenic industrial agents such as coal tar, pitch, mineral oil and petroleum oil (occupational acne).
Ingestion, inhalation or transcutaneous penetration of halogenated aromatic hydrocarbons, including the
polychlorobiphenyls in paint, varnishes, lacquers, fungicides, insecticides, herbicides, wood preservatives
and various oils, produces a distinct form of occupational acne (chloracne). Within a few months of
sufficient exposure, open and closed comedones appear on the chest, temples and behind the ears.
Inflammatory lesions may follow.16
Physical pressure from headbands, violins, chin straps, sports helmets, guitar straps and orthopedic
braces has induced localized acne (acne mechanica). Mechanical friction should be eliminated or
reduced. Wool or other rough textured fabrics and occlusive clothing may also be irritants.
Acne patients may manipulate their comedones and pustules with finger pressure by picking, excoriating
or pinching in an attempt to drain lesions, often subconsciously or during sleep (acne excoriée). Crusting
erosions, scarring and hyperpigmentation may result from the ensuing rupture and inflammation.
Diet has been the focus of investigations, with studies indicating a correlation between acne and a
Western diet.3 In the past, it was thought that acne was not influenced by diet, but a balanced diet should
be advised for overall health. In studies examining diet and acne, patients could choose to restrict the
intake of certain foods they perceived as exacerbating acne (chocolate, cola drinks, milk and milk
products).17,18 Conclusions were based on results of a methodologically flawed study that was conducted
over 40 years ago, showing no significant differences in lesion count or sebum characteristics following
ingestion of an enriched chocolate bar vs. a control bar without cocoa butter and chocolate liquor.18 A
subsequent small study also showed no differences in count or grade of acne in medical students who
were asked to consume the food they thought most likely to worsen acne, for 7 days.19 The information
from these studies was likely over-interpreted to dismiss potential effects of diet on acne.
Beginning in 2005, a series of studies have linked consumption of dairy products with acne, perhaps due
to natural hormonal components and/or other bioactive molecules in milk.20,21,22 The Nurses Health
Study, which involved 47 355 women, used retrospective data on diet during high school and found an
association between acne and intake of milk.
Insulin-like growth factor (IGF) may play a role in acne.23,24 IGF is increased by ingestion of high glycemic
loads and so could potentially link diet and acne. A Cochrane review concluded there is some low quality
evidence from a single trial25 that a low-glycemic-load diet may reduce total skin lesions in acne.26 While
improvements in acne and insulin sensitivity suggest the role of nutrition-related lifestyle factors in acne
pathogenesis, the independent effects of weight loss vs. dietary intervention need to be isolated.27
The possible role of dietary factors in acne cannot be dismissed as studies to date have not been
sufficiently large or robust. While still controversial, diet may play a role in the development or progression
of acne and further studies are ongoing.26,28,29,30
Environmental factors including heat and humidity may induce comedones, while pressure, friction and
excessive scrubbing or washing can exacerbate existing acne by causing microcomedones to rupture.
Hairstyles low on the forehead or neck or occlusive clothing may cause excessive sweating and worsen
acne.31 Sunlight may be palliating. Studies examining the relationship between tobacco smoking and acne
show inconsistent results. However, dermatologists have begun to counsel people to quit tobacco
smoking as a potential auxiliary treatment for acne.32
Emotions such as intense anger and stress can exacerbate acne, causing flares or increasing mechanical
manipulation. Two-thirds of affected teenagers wish that they could speak with their healthcare provider
about acne, but only one-third actually do.33
Acne is rarely misdiagnosed. The most commonly mistaken conditions include rosacea, perioral
dermatitis, gram-negative folliculitis and drug-induced acne.34
Acne rosacea, often called adult acne, is a chronic, relapsing condition involving blood vessels, occurring
after age 30 in fair-complexioned persons, commonly Celtic. The first sign is easy flushing (redness or
erythema), followed by development of inflammatory lesions with edema, papules and pustules appearing
on the nose, cheeks, chin and forehead, with telangiectasia (spider veins) appearing as the condition
progresses. It may be sensitive to the touch. It differs from acne vulgaris in several ways: onset is not
linked to increased androgens or endocrine changes, comedones are not usually present and aggravating
factors include alcohol ingestion, spicy foods, smoking, overexposure to sunlight, hot drinks (especially
those containing caffeine), temperature extremes, friction, irritating cosmetics and corticosteroid use. It is
not curable and progressively worsens, and may ultimately result in rhinophyma (enlarged nose).
Treatment with antibiotics, particularly topical metronidazole, may be required.35
Perioral dermatitis occurs primarily in young women and adolescents and is characterized by erythema,
scaling and papulopustular lesions commonly clustered around the nasolabial folds, mouth and chin. The
cause is unknown.34
Gram-negative folliculitis (Proteus, Pseudomonas, Klebsiella) may complicate acne, presenting as a sudden
change to pustules or large inflammatory cysts occurring after long-term treatment of acne with oral
antibiotics. Folliculitis may occur due to staphylococci. There is a sudden onset of superficial pustules
around the nose, chin and cheeks.34
Several conditions include acne as a characteristic component, and understanding the mechanisms
involved in these syndromes provides insight into acne pathogenesis. They include polycystic ovary
syndrome (elevated androgen levels), PAPA syndrome (pyogenic arthritis, pyoderma gangrenosum, acne—
early onset arthritis with increased inflammatory activity) and SAPHO syndrome (synovitis, acne,
pustulosis, hyperostosis, osteitis syndrome—sterile inflammatory arthro-osteitis, with P. acnes as a
possible trigger).6
Table 2 summarizes conditions included in the differential diagnosis of acne.
a
Table 2: Differential Diagnosis of Acne
Acne Variant Comedones Pustules Papules Nodules Other
Open Closed
Vulgaris + + + + +
Drug-induced +/− + +
Neonatal + + +/−
Conglobata + ++ ++ Cysts, abscesses,

sinus tracts
Fulminans + ++ ++ Ulcerating cysts
Contact
pomade ++ +
cosmetic + ++ ++ +
occupational ++ + +
(e.g.,
exposure to
oil)
Acne Variant Comedones Pustules Papules Nodules Other
Open Closed
chloracne ++ ++ + +
Endocrine ++ + +
Excoriated + + Crusts, scars,

erosions,
hyperpigmentation
Mechanical ++ ++ +
Rosacea + + +/− Erythema, edema,

telangiectasia
a Other conditions that present with raised lesions resembling papules or pustules include milia, folliculitis (gram-
negative, staphylococcal, Candida), impetigo, warts, dental sinuses and epidermoid cysts.
Drug-induced Acne
Certain drugs may cause acneiform eruptions (Table 3). Systemic corticosteroids can cause a pustular
inflammatory form of acne, especially on the trunk; onset is abrupt, 2–6 weeks after initiation of therapy.
Acne has also been associated with most of the potent topical corticosteroids, but not with
hydrocortisone, which lacks the ability to inhibit protein synthesis. Discontinuation of the corticosteroid
results in an initial worsening of the appearance due to removal of the anti-inflammatory action of the
corticosteroid itself. Caution patients about this reaction, which can be subdued through judicious use of
topical hydrocortisone.38,39,40
Antiepileptics and tuberculostatics are most commonly implicated in drug-induced acne, followed by
lithium. Other metals that can induce acne include cobalt in vitamin B12.41 Halogens, especially an excess
of iodide in seafood, salt and health foods, can worsen acne.
As well, certain minor cosmetic ingredients have been implicated in cosmetic acne, including isopropyl
myristate, cocoa butter and fatty acids.2
36,37
Table 3: Drug-induced Acne
Drugs that May Produce Acne-like Eruptions (Comedonal and/or Inflammatory)
Hormones: Tuberculostatic Drugs:

Anabolic steroids Ethambutol
Androgenic hormones in women Isoniazid
Corticosteroids Miscellaneous:
Corticotropin (ACTH) Azathioprine
Oral contraceptives (especially those with high Coal tar
progestin component) Cyclosporine
Halogens: Dantrolene
Bromides Epidermal growth factor receptor (EGFR)
Chlorides Gold salts
Halothane Lithium salts
Iodides Maprotiline
Antiepileptic Drugs:
Phenobarbital Psoralens
Phenytoin Quinidine
Quinine
Vitamins B2, B6 and B12
Drugs that May Produce Inflammatory Papular/Pustular Eruptions or Folliculitis (Occlusion of

Hair Follicles)
Carbamazepine Isoniazid
Cefazolin Naproxen
Cephalexin Norfloxacin
Chloramphenicol Piperazine
Furosemide Pyrimethamine
Dactinomycin Streptomycin
Diltiazem Sulfamethoxazole/trimethoprim
Tetracyclines
Quality of Life (QOL) Indicators
QOL indicators represent patients' perceptions of and reactions to their health. This is important in patient
assessment as it relates to patients' understanding, expectations, concerns and behaviour regarding acne
therapy as a self-care option. Assessing patients' acne-related impairment in QOL may aid in management
by evaluating the psychological impact of their acne, which may not correlate with the clinical severity, aid
in detection of depression or need for psychological care, and improve therapeutic outcomes. Examples of
global scales that have been used to evaluate acne include Skindex42 and the Dermatology QOL Index;43
examples of acne-specific scales include the Acne-specific QOL questionnaire44 and the Acne QOL
Scale.45
Figure 3 provides an approach to the assessment of patients with acne.
Specialist Consultation for Complicated Acne
Patients may require further investigation, additional therapy or other modalities in the following
situations:
Acne is drug-induced or due to a known endocrinopathy (e.g., polycystic ovarian syndrome as may be
suspected with hirsutism, weight gain)
Acne at a very young age (may need endocrinology consult)
Moderate to severe acne
Acne that is nonresponsive to initial therapy
Presence of scarring, especially if moderate to severe.
Figure 4 provides an approach for treating acne with nonprescription medication.
Cleansing: Patients should wash no more than twice daily with a mild soap or soapless cleanser. Patients with
acne may wash too frequently, attempting to remove surface oils. There is no evidence this is helpful since
surface lipids do not affect acne.46 Contributory lipids are deep in the follicle and cannot be removed through
washing. Antiseptic cleansers, while producing a clean, refreshed feeling, remove only surface dirt, oil and
aerobic bacteria. They do not affect P. acnes. There is no evidence that one washing regimen is superior to
another. Scrubbing should be minimized to prevent follicular rupture. Soaps produce a drying effect on the
skin due to detergent action. As medicated cleansers require increased contact time, this drying action is
pronounced, especially with peeling agents. Avoid cream-based cleansers.
Shaving: Males should try both electric and safety razors to determine which is more comfortable. When
using a safety razor, the beard should be softened with soap and warm water or shaving gel. Shaving should
be done as lightly and infrequently as possible, using a sharp blade and avoiding nicking lesions. Strokes
should be in the direction of hair growth, shaving each area only once.
Comedone extraction: Comedone extraction by the patient is useful and painless. It results in immediate
cosmetic improvement although it has not been widely tested in clinical trials. Pretreatment with a peeler for
4–6 weeks often facilitates the procedure.40 Following cleansing with hot water, a comedone extractor is
placed over the lesion and gentle pressure applied until the contents are expressed. This removes unsightly
lesions, preventing progression to inflammation. A correctly sized extractor allows the central keratin plug to
extrude through the opening. The small end of a plastic eye dropper, with bulb removed, may also be used.
These instruments should be cleaned with alcohol after each use. Some initial reddening may be apparent. If
the contents are not expressed with modest pressure, patients should not continue since improper extraction
may further irritate the skin. A healthcare practitioner should be consulted if this technique is too difficult for
the patient to manage. Since the follicle is difficult to remove completely, comedones may recur between 25–
50 days following expression. Fewer than 10% of comedone extractions are a complete success, but the
process is useful if done properly.2
Ultraviolet light: Although ultraviolet light was recommended in the past for desquamation, it is no longer
advised since the carcinogenic and photoaging effects of ultraviolet exposure are well established. Moreover,
inflamed skin is more susceptible to the damaging effects of ultraviolet light. Patients using tretinoin may
show heightened sensitivity to ultraviolet light.47 Acne patients should apply sunscreen (SPF ≥15) with an
alcohol- or oil-free base and avoid using the acnegenic benzophenones (see Prevention and Treatment of Sun-
induced Skin Damage).
Encourage patients with acne to discontinue or avoid any aggravating factors, to maintain a balanced, low-
glycemic-load diet (see Weight Management) and control stress. Evidence shows that by being empathetic
and informative during counselling, the health practitioner may motivate the patient to continue long-term
therapy.31,33,34
Prevention of Cosmetic Acne
Persistent low-grade acne in women after their mid-twenties is frequently caused by heavy cosmetic use.
Adolescent acne in younger women may be exacerbated with makeup overuse. The problem is
perpetuated when the resultant blemishes are concealed with more cosmetics.
Advise patients to stop using oil-containing cosmetics and avoid cosmetic programs that advocate
applying multiple layers of cream-based cleansers and cover-ups, which are advertised through the media
and often available through Internet shopping with promotional bonuses. Three-step basic systems
usually combine medicated and nonmedicated ingredients, although it may not be apparent that
therapeutic agents are included. They often start with cleansers, in lotions or creams, which may contain a
multitude of unnecessary ingredients, including medicated peelers, oils, fragrances and preservatives.
Drugs commonly included are subtherapeutic or low doses of salicylic acid, sulfur or benzoyl peroxide.
The second step is generally a “toner” or “refresher” that is usually water- or alcohol-based and might
contain medicated ingredients such as alpha-hydroxy acids (e.g., glycolic acid, a mild comedolytic) or even
glycerin as a humectant. The final product may be called intensive or repairing solution, usually lowest-
strength combinations of peelers such as benzoyl peroxide, sulfur or salicylic acid, plus potentially
sensitizing fragrances and preservatives, or oil-soluble sunscreens that are not identified on the label.
Bases may have significant oil content. There may be additional products to supplement as necessary to
the base routine of 3 steps, such as masks or spot treatments. Multiple-step cosmetic programs are often
costly, and contain subtherapeutic concentrations of ingredients that are not necessarily first line.48 They
should be avoided in favour of simple cleansers and more effective single-ingredient peelers, at optimal
concentrations. Creams and cosmetics used during a beauty salon facial may precipitate acne in
susceptible patients.
Patients with acne should wash twice daily with a mild soap or a soapless cleanser, and restrict cosmetics
including makeup, moisturizers and sunscreens to oil-free rather than water-based products. Since the
spread time of oil-free makeup is lower (i.e., they “sink in” to the skin more quickly), best results are
achieved if they are applied to one-quarter of the face at a time. Topical medication should be applied after
gentle cleansing.49
Cover-up cosmetics for acne are available in several skin tones, in lotion and cream forms. They may be
applied as cosmetics 2–3 times daily, over the entire face or to individual lesions. They are usually water-
based, nongreasy preparations, often containing peeling agents, antibacterials or hydroquinone. Most
contain sulfur. However, nonmedicated, oil-free makeups are preferable to water-based products. Water-
based cosmetics may contain significant amounts of oil in the form of undiluted vegetable oils, lanolin,
fatty acid esters (butyl stearate, isopropyl myristate), fatty acids (stearic acid), fatty acid alcohols, cocoa
butter, coconut oil, red veterinary petrolatum and sunscreens containing benzophenones.50,51 These are
more likely than oil-free products to contribute to pore blockage. The term “noncomedogenic” may refer to
either water-based vehicles or products that are free of substances known to induce comedones. They are
not necessarily oil-free.
Lipstick, eye shadow, eyeliner, eyebrow pencils and loose face powders are relatively innocuous. Heavier,
oil-based preparations, particularly moisturizers and hairsprays, clog pores and accelerate comedone
formation.52
Since the action of most therapeutic acne agents is to dry the skin, the use of moisturizers should be
carefully considered to select the most appropriate product. Active agents such as alpha-hydroxy acids
(glycolic, lactic, pyruvic and citric acids) may be present in the cosmetic formulation since they reduce
corneocyte adhesion.2 Patients with acne should use only oil-free products unless absolutely necessary
due to treatment with strong drying agents or isotretinoin. Many marketed moisturizers are considered
noncomedogenic.
The most critical target for treatment is the microcomedone, because without the follicular occlusion, the
whole cascade of acne is arrested. This will involve a combination of preventive measures (to reduce or
eliminate risk and aggravating factors) and treatment measures. These should integrate nonpharmacologic
and pharmacologic protocols aimed at cleansing as well as targeting all 4 mechanisms involved in acne
pathogenesis. Combination therapy to target multiple pathogenic steps is often more effective than
monotherapy and may offer secondary advantages of decreasing agent-related side effects and minimizing
resistance or tolerance to individual treatments. It takes 8 weeks for a microcomedone to mature, thus any
therapy must be continued beyond this duration to assess efficacy.40 Recommendations should be based on
critical evaluation of the literature combined with clinical experience.
Because acne is a chronic disease, lesions typically recur for years. Microcomedones significantly decrease
during therapy but rebound almost immediately after therapy is discontinued. Hence, the strategy for treating
acne includes an induction phase followed by a maintenance phase, which are further supported by
adjunctive treatments and/or cosmetic routines. Maintenance therapy with regular use of appropriate agents
reduces the potential for recurrrence of visible lesions. To achieve successful long-term treatment,
maintenance therapy must be tolerable, appropriate for the patient's lifestyle and convenient. It will continue
for months to years depending on the patient's age. Education about the pathophysiology of acne and the
psychosocial benefits of clearer skin may improve patient adherence to consistent therapy which will sustain
remission.
Information about treating acne with nonprescription products can also be found in Figure 4 and Table 5.
More information about further therapy for acne can be found in Compendium of Therapeutic Choices: Acne.
Ailments—Skin Care Products: Acne.
Medicated Soaps and Washes

Medicated soaps, washes and foams may contain topical antiseptics or peeling agents such as salicylic
acid, sulfur, benzoyl peroxide or clindamycin, alone or in combination in low concentrations. Most washes
should remain on the skin from 15 seconds to 5 minutes followed by thorough rinsing, limiting the amount
of time the active ingredient is in contact with the skin. Other cleansers are applied after washing and left
on the skin without rinsing. Quaternary ammonium compounds are cationic detergents that are
inactivated quickly in the presence of organic material, such as sebum. The duration of action of these
products is short. Evidence of effectiveness of cleansers is limited. One small study found cleansers
effective in reducing inflammatory and noninflammatory lesions.53
Bacteriostatic soaps such as hexachlorophene, carbanilides and salicylanilides (halogenated

hydroxyphenols) have been found to be acnegenic.46 Few ordinary soaps induce acne. However, patients
with acne are particularly susceptible to comedogenic contactants, and if bacteriostatic soaps are applied
several times daily for long periods, they may aggravate the skin. Soaps containing coal tar, which can
induce folliculitis, are not indicated for acne.
Polyester cleansing sponges (e.g., Buf-Puf) are synthetics that abrade the skin surface, removing
superficial debris. They are unlikely to unseat comedones, considering the structure of these lesions. The
sponges are available in soft or coarse textures, with or without soap. Caution patients against using a
circular or rubbing motion that will increase irritation, and instruct them to use single, gentle, continuous
strokes on each side of the face, from the midline out towards the ears.
Alcohol-detergent medicated pads, impregnated with salicylic acid 0.5%, reduce inflammatory lesions
and open comedones in mild to moderate acne. This type of medication is less abrasive, not rinsed off
and convenient.54
Alcohol-detergent wipes, swabs or “pledgets” impregnated with antibiotics, such as clindamycin, are
available. The antibiotic is deposited in low concentrations on the surface of the skin, and may not
penetrate to the depths of the pilosebaceous duct. Although patients may like the convenience and
perception of using an active agent, these products should not be recommended over simple cleansing.
Cationic (C) bond strips that become activated by water are available. Dirt/oil in the pores is anionic. As
the strip dries, the C-bond binds the anionic dirt and removes it when the strip is peeled off.
Abrasives consist of finely divided particles of fused aluminum or plastic together with cleansing and
wetting agents. Abrasives peel and remove surface debris and may assist resorption of papules and
pustules but despite vigorous rubbing, removal of comedones is not accomplished. Particles such as
sodium tetraborate decahydrate, dissolve on contact, limiting their usefulness as abrasives.55 Abrasive
cleansers containing polyethylene granules are not more effective than the same cleansing agent without
the abrasive granules. These products are not indicated in most cases but may be used in a patient who
responds empirically.56
Vehicles
The formulation must balance the technical characteristics of maintaining and delivering the drug in an
active state together with the need for an elegant product that the patient will enjoy using, so that it is
more likely to be applied as required and deliver the full benefit of the active agent. Physically and
chemically, the vehicle itself or its contents attempts to do 1 or more of the following: reduce excess oil,
control bacteria associated with acne, reduce the effects of hyperkeratinization and unclog pores.
Performance, safety and stability should be maximized while addressing technical and commercial
factors.
Immiscible liquids might be delivered in oil-in-water or water-in-oil emulsions. In addition to having the
undesirable oil content, these vehicles also contain humectants, thickeners, preservatives and fragrance,
which may be problematic.
Cleansers often utilize surfactant systems to de-fat the skin surface. Oil is dispersed from the skin into the
surfactant system; however, the active ingredient is sometimes trapped and removed on rinsing. As well,
the balance between cleanliness and drying or irritation should be taken into account. Most patients prefer
products with foaming action, and these must contain additional secondary surfactants to enhance the
foam and condition the skin. Soaps are the most widely used cleansing products, but do not lend
themselves to efficient delivery of active drug. Two main disadvantages are: as soaps are rinsed off, the
deposit of active agent will be small, and the high pH required in soaps may degrade some active
ingredients and be less tolerable on sensitive skin. Soapless cleansers are alternatives to soaps.57
Solutions are simpler formulations; there is a trend to use them as the soaking liquid for wipe products
made with fibrous cloths. Use of these products requires consideration of whether packages are
resealable if they contain multiple wipes, and whether the volatility of the solvent will affect storage and
availability of the active agent, or cause crystallization. Solutions are used mainly with topical antibiotics,
which are often dissolved in alcohol. Glycolic acid 8% solution is available for use alone or for
incorporation in topical antibiotic preparations. Solutions and washes can be more easily applied to large
areas such as the back.58
Select nongreasy solutions, gels, lotions and creams as bases for topical acne preparations. Gels are very
useful as they are totally oil-free mixtures of water or alcohol, whereas lotions and creams contain some
oil phase. Discourage use of moisturizers and oil-based products. Lotions are slightly less drying than gels
while creams are more emollient. Many gels contain ethanol or isopropyl alcohol. Isopropyl alcohol is
more lipid soluble and may be preferred. Propylene glycol is sometimes present in small amounts to add
viscosity and lessen the drying effects of strong peeling agents. Gels are drying but may cause a burning
irritation in some patients and may prevent certain kinds of cosmetics from adhering to the skin.59
Propylene glycol gels are easy to apply and dry without a visible or sticky film. Nonalcoholic gels may be
as effective and less drying than alcoholic solutions. Alcoholic or acetone gels are usually more drying and
provide better penetration of the active ingredient.
Consider the patient's skin type and preferences in the choice of vehicle for topical agents: patients with
oily skin may prefer vehicles with higher proportions of alcohol (solutions and gels) while those with dry or
sensitive skin may prefer nonirritating lotions and creams. Lotions can be used with any skin type and
spread well over hair-bearing skin, but will burn or dry if they contain propylene glycol. Also consider the
compatibility of vehicles and agents with cosmetics.60
Effect of the vehicle alone may be quite substantial in topical therapy. One study estimated vehicle effect
to account for an average of 55% (range 35–82%) of reduction in lesion counts for 8 commonly prescribed
topical preparations.
How to use topical preparations: To prevent new lesions from developing, topical preparations should not
be applied to individual lesions but to the whole area affected by acne, using care around the eyelid, mouth
and neck, which chafe easily. Lotions should be applied with a cotton swab once or twice a day after
washing or at bedtime if they leave a visible residue. Skincare products may cause dryness and redness,
particularly in the early stages of treatment. Should this occur, the product can be applied less frequently,
stopped for a while, or switched to different product. Applying a topical vehicle with a high water content a
few minutes after applying the medicinal product may reduce irritation. Initial irritation usually subsides as
the skin becomes accustomed to the product.
Exfoliants (Peeling Agents)
Exfoliants induce continuous mild drying and peeling by primary irritation, damaging the superficial layers
of the skin and inciting inflammation. This stimulates mitosis, thickening the epidermis and increasing
horny cells, scaling and erythema. A decrease in sweating results in a dry, less oily surface and may
superficially resolve pustular lesions.
Resorcinol, a phenol derivative, has good solubility in both water and alcohol and is heat stable, and is
incorporated into a variety of products, including emulsions.61 Protective packaging is important as
resorcinol is reactive to light and oxygen. It is less keratolytic than salicylic acid and may be both
bactericidal and fungicidal. It is an irritant and sensitizer and should not be applied to large areas of the
skin or on broken skin. It produces a reversible, dark brown scale on some dark-skinned individuals.
Products containing resorcinol 1–2% have been used for acne, often in combination with other peeling
agents such as sulfur or salicylic acid. The US Food and Drug Administration (FDA) considers resorcinol
2% and resorcinol monoacetate 3%, in combination with sulfur 3–8%, to be safe and effective. These
ingredients may enhance the activity of the sulfur.62
Salicylic acid is a beta-hydroxy acid that penetrates the pilosebaceous unit (Table 5). It has comedolytic
activity, although the concentration in commercial preparations (less than 2–3%) is generally low. While
concentrations less than 2% may actually increase keratinization, concentrations between 3 and 6% are
keratolytic, softening the horny layer and shedding scales. Salicylic acid's mechanism remains unresolved,
attributed to reduced cohesion of corneocytes and shedding of epidermal cells, rather than “lysing” of
keratin. It has no effect on mitotic activity of normal epidermis and does not influence disordered
cornification.63 It may also provide mild antibacterial value, as it is active against P. acnes. It also offers
slight anti-inflammatory activity at concentrations ranging from 0.5–5%. Its efficacy against comedones
prevents the development of inflamed lesions; this represents a type of delayed or secondary efficacy.64
Salicylic acid products are often used as first-line therapy for mild acne because of their wide availability.
They are available in alcohol-detergent–impregnated pads as well as washes, bars and semisolid vehicles.
Lower concentrations are sometimes combined with sulfur to produce an additive keratolytic effect.
Concentrations of 5–10% can be used for acne, beginning with a low concentration and increasing as
tolerance to the irritation develops. It is an effective agent, although as a peeling agent its comparative
potency varies according to the model used in measurement. It is slightly less potent than equal-strength
benzoyl peroxide when measured with the rabbit ear animal model, and slightly more potent when
measured with a biologic microcomedone model.64 It may have anti-inflammatory properties that help dry
inflammatory lesions.24 Its keratolytic effect may enhance the absorption of other agents. Salicylic acid
may cause some degree of local skin peeling and discomfort (burning or reddening) as it is a mild irritant.
It is not a sensitizer. Although recognized by the FDA as safe and effective, salicylic acid offers no
advantages over other topical agents such as benzoyl peroxide.62,63,65
In high concentrations of 20–30% in hydroethanolic vehicles, salicylic acid can be used as a single or
multiple peeling agent for comedonal or papular acne and hyperpigmentation. It has been shown to
extrude closed and open comedones several days post-peel,66 and to be effective for inflammatory and
noninflammatory acne67 but must be applied under strict control to offer this adjunctive benefit when
treating acne.
Sulfur is used in the precipitated or colloidal form in concentrations of 2–10% since it is practically
insoluble in water and must be well dispersed. Stability depends on effective maintenance of the
dispersion.61 Sulfur compounds (e.g., sulfides, thioglycolates, sulfites, thiols, cysteines and thioacetates)
are also available and are somewhat weaker. Sulfur-based medications often lessen the severity of acne,
presumably because of keratolytic and antibacterial action. Sulfur helps resolve comedones via its
exfoliant action. Sulfur's popularity stems from its mild antibacterial action and its ability to quickly resolve
pustules and papules, mask and conceal lesions (similar to a thick foundation lotion), and produce
irritation leading to skin peeling. Sulfur can cause slight ophthalmic and dermatologic irritation and
patients should be cautioned to avoid eye contact. Use should be discontinued if excessive irritation
results. Although it is often combined with salicylic acid or resorcinol to increase its effect, use is limited
by its offensive odour and the availability of more effective agents.68 Sulfur meets the criteria of the FDA
Advisory Review Panel for nonprescription topical acne products and is considered safe and effective
when used alone, but its antibacterial effects are not recognized. Sodium thiosulfate, zinc sulfate and zinc
sulfide are not considered safe and effective.
Glycolic acid (an alpha-hydroxy acid) is a humectant that increases water content of the stratum corneum
and decreases corneocyte cohesion, and thus may increase desquamation and promote hydration. There
is some evidence of efficacy of glycolic acid alone69 or in combination with other agents70,71 in the
treatment of acne. Glycolic acid is also frequently used in higher strengths (40%) as a chemical peel. Use
of a glycolic acid 40% peel at least 5 times (at 2-week intervals), as an adjuvant to the treatment of
moderate facial acne, resulted in reduction of noninflammatory lesions in 1 study.72
Azelaic acid is another alpha-hydroxy acid effective in the treatment of acne.3 It has comedolytic and
antibacterial effects but does not promote resistant organisms. It is mildly irritating and may cause
hypopigmentation. In Canada it is not officially indicated for use in acne.
The topical retinoids, which include tretinoin, adapalene, and tazarotene, are the most powerful topical
peeling agents. Normal epithelial cell differentiation is a vitamin A–dependent process. Because retinoids
reverse the abnormal keratinocyte desquamation found in acne,47 members of the retinoid family are
highly active peelers. They improve acne by inhibiting microcomedone formation, diminishing the number
of mature comedones and subsequently of inflammatory lesions, and by normalizing follicular epithelium
maturation and desquamation.
Retinoids also have a secondary effect that facilitates acne clearance. By loosening and decreasing
corneocytes, they increase skin permeability and facilitate absorption of other agents such as
antimicrobials or benzoyl peroxide and penetration of oral antibiotics into the follicular canal. This
decreases the overall duration of antibiotic treatment and lessens the possibility of resistance. Therefore,
combination products with oral or topical antimicrobials are useful due to their increased efficacy, faster
onset, decreased total antibiotic use (and therefore decreased risk of resistance) and shorter duration of
treatment.47
Topical retinoids tend to produce remissions that are maintained for extended periods of time, provided
the accompanying irritation does not impede patient adherence. Side effects including erythema, xerosis,
burning and desquamation are issues for many patients. Application should be at night, 30 minutes after
cleansing, starting with every other night for 1–2 weeks to adjust to irritation. During the winter months or
for patients with sensitive skin, advise short contact time starting with 2 minutes and adding 30 seconds
per dose; discontinue and resume after a 3-day rest if undue irritation results. Doses can be increased
after 4–6 weeks use of the lowest concentration and with the least irritating vehicle. Gels and creams are
less irritating than solutions. Adapalene and tazarotene are photoirritants not photosensitizers, and sun
avoidance and sunscreen use are imperative.47
Retinoids may also improve and prevent postinflammatory hyperpigmentation, often seen in darker
complexions.
Retinoids are teratogens. Safety of topical retinoids during pregnancy has not been documented and their
use remains contraindicated. A meta-analysis showed no increase in major congenital malformations,
spontaneous abortions, low birthweight and prematurity in babies exposed to topical retinoids during the
first trimester. This information may be useful to reassure women who were inadvertently exposed, but is
not adequate to justify use of topical retinoids during pregnancy.73
Overall, topical retinoids are the cornerstone of prescription acne treatment and are a safe, effective and
economical means of treating all but the most severe cases, and should be the initial first step in
moderate acne, alone or in combination with antibiotics and benzoyl peroxide, reverting to retinoids alone
for maintenance once adequate results are achieved.
Antibacterials
Choices for antibacterial therapy include benzoyl peroxide, as well as prescription topical and systemic
antibiotics and combination products. These drugs kill P. acnes and inhibit the production of pro‐
inflammatory mediators by organisms that are not killed.4
Benzoyl Peroxide
Benzoyl peroxide, a derivative of coal tar, is effective in the treatment of acne.74 Alone, or in combination,
it is part of the standard of care for mild to moderate papular-pustular acne.75 Benzoyl peroxide is well
absorbed through the stratum corneum and concentrates in the pilosebaceous unit. It has 3 principal
actions useful in both inflammatory and noninflammatory acne. Firstly, it produces powerful anaerobic
antibacterial activity due to slow release of oxygen, expressing bactericidal activity against gram-positive
and gram-negative bacteria, yeasts and fungi; this nonspecific antibacterial mechanism does not induce
resistance with long-term use.64 Secondly, it has a rapid (within 2 hours) bactericidal effect that lasts at
least 48 hours. As a result, it may decrease the number of inflamed lesions within 5 days. Thirdly, it
induces depression of sebum production—this is not a direct effect, nor does it reduce skin surface lipids,
but it is effective in reducing free fatty acids, which are comedogenic agents and triggers of inflammation.
Topical benzoyl peroxide 5% lowers free fatty acids by 50–60% after daily application for 14 days, and
decreases aerobic bacteria by 84% and anaerobic bacteria (primarily P. acnes) by 98%.2 Since its primary
effect is antibacterial, it is most effective for predominantly inflammatory acne.
Topical benzoyl peroxide also produces comedolysis. Studies using native microcomedones show an
anticomedogenic effect that is slight compared with tretinoin or salicylic acid.61,76 Many patients with
noninflammatory comedonal acne will respond to its peeling action.
Benzoyl peroxide's antiacne effect is augmented by increased blood flow, dermal irritation, local anesthetic
properties and promotion of healing.77,78,79,80
Cleansers containing benzoyl peroxide are available as liquid washes and solid bars of various strengths.
The desquamative and antibacterial effectiveness in a soap or wash is minimized by limited contact time
and removal with proper rinsing. Stable lotions are available in concentrations of 2.5, 5 and 10%. Alcohol
and acetone gels facilitate bioavailability and may be more effective, while water-based vehicles are less
irritating and better tolerated. A benzoyl peroxide 4% hydrophase gel (Solugel) suspends crystals of
benzoyl peroxide in a dimethylisosorbide solvent as the water in the base evaporates. The resulting
solution is absorbed by the skin, leaving no film. The manufacturer claims the resulting efficacy is equal to
benzoyl peroxide 10% with irritation equivalent to that of a 2.5% concentration in aqueous-base gel, and
may be an alternative for the patient with easily irritated skin who requires additional potency. This vehicle
is easily combined with prepackaged clindamycin or erythromycin powders. Paste vehicles are stiffer and
more drying than ointments or creams, facilitating absorption of the active ingredients and allowing them
to stay localized.
Benzoyl peroxide 2.5% is equivalent to the 5% and 10% formulations in reducing the number of
inflammatory lesions. The lower strength may not be as effective a peeler (which is due to an irritancy
reaction) compared with higher strengths. Irritant side effects with the 2.5% gel are less frequent than with
the 10% gel but equivalent to the 5% gel. The lowest concentration of benzoyl peroxide should be used for
treating patients with easily irritated skin and may lessen irritation when used in combination topical
therapy with comedolytic agents.
Benzoyl peroxide is combined with topical antibiotics or retinoids to improve efficacy, allow reduction in
dosage of antibiotics or retinoids, decrease irritation, and reduce development of resistance to
antibiotics.81,82,83 Benzoyl peroxide has also been used in combination with other antiacne medications,
such as sulfur, chlorhydroxyquinoline or urea, an ingredient used to facilitate drug delivery. No significant
improvement has been demonstrated.
Benzoyl peroxide may bleach hair and fabrics such as towels, bedding and clothing. Odour from
breakdown of benzoyl peroxide may remain on clothing and bedsheets.
Benzoyl peroxide produces a mild primary irritant dermatitis that settles with continued use, and is more
likely to occur in those who have fair complexions or susceptibility to irritation, or who sunburn easily.
Irritation is dependent on the concentration and vehicle—higher with alcoholic gels compared with
emulsion bases. Contact allergic dermatitis is reported rarely. Cross-reactions with other sensitizers,
notably balsam of Peru and cinnamon, are well established. It may cross-sensitize to other benzoic acid
derivatives such as topical anesthetics. Concomitant use of an abrasive cleanser may initiate or enhance
sensitization.84
There is no evidence that the normal use of benzoyl peroxide in the treatment of acne is associated with
an increased risk of facial skin cancer in humans, although links have been made in mice experiments.
Overall, the cutaneous use of benzoyl peroxide is safe, and is recognized by the FDA as category 3, which
means that more information is required to make a final determination of safety and efficacy for
nonprescription use.85,86,87,88
Preparations of benzoyl peroxide are available in concentrations up to 10%. Recommend the weakest
concentration (2.5%) in a water-based formulation or the 4% hydrophase formulation for anyone with a
history of skin irritation or who must use combination therapy.89 There are many suggested routines for
initiating therapy. One is to gently cleanse the skin and apply the preparation for 15 minutes the first
evening, avoiding the eyes and mucous membranes. A mild stinging and reddening may appear. The time
should be doubled each evening until the preparation is left on for 4 hours and subsequently all night.
Dryness and peeling will appear after a few days. Once tolerance is achieved, the strength may be
increased to 5% or the base changed to acetone or alcohol gels or paste. Alternatively, benzoyl peroxide
can be applied for 2 hours for 4 nights, 4 hours for 4 nights, and then left on all night. It is important to
wash the product off in the morning. Other drying agents should be discontinued. Patients with very
sensitive skin or demonstrated sensitivity to benzoyl peroxide should not use the product, and it should be
discontinued if irritation becomes severe upon use. Contact with eyes, lips or mouth should be avoided.
A sunscreen (see Prevention and Treatment of Sun-induced Skin Damage) is recommended if benzoyl
peroxide is used. To avoid interactions, apply the sunscreen during the day and the benzoyl peroxide at
night.
Comparison of salicylic acid and benzoyl peroxide: While both of these ingredients are used for mild to
moderate acne, their mechanisms differ and therefore the type of acne most responsive to each varies.
Benzoyl peroxide is a strong antibacterial, while salicylic acid acts primarily through keratolysis. Salicylic
acid is equal or slightly superior to benzoyl peroxide in reducing the number of comedones and
subsequently the number of inflammatory lesions, since it interferes with an earlier step in pathogenesis—
formation of the primary lesion of acne, the microcomedone—and thus could be superior in acting against
later steps.63,65 However, studies did not use identical formulations; the base itself has an effect and
influences penetration and duration of action. Salicylic acid is superior to benzoyl peroxide in retarding
comedone formation. Benzoyl peroxide, as an antibacterial with some peeling effects, is considered the
nonprescription and cosmetic gold standard for milder acne. It is used alone or in combination with other
antibacterials or peelers, to increase efficacy and improve tolerability.
Topical and Oral Antibiotics
In addition to reduction of P. acnes as the mechanism for efficacy in acne treatment, certain antibiotic
drugs are also potent anti-inflammatory agents via other mechanisms. The induction of resistance has
made antibiotic therapy problematic in many patients, particularly because therapy is directed at control
over a long time period.90
Topical and oral erythromycin and topical clindamycin, well-established acne treatments, have become
less effective since the early 1990s due to resistance of P. acnes.90 Addition of benzoyl peroxide to the
antibiotic regimen is more effective than monotherapy, and mitigates against survival of resistant P. acnes
populations. Clindamycin is preferred because of its potent action and lack of absorption. It is available as
a single-ingredient topical preparation and can also be combined with benzoyl peroxide. Erythromycin is
available in combination with tretinoin or benzoyl peroxide. Some topical antibiotic-benzoyl peroxide
combinations require refrigeration.
The tetracycline antibiotic family has well-understood antibacterial effects and anti-inflammatory effects
that target an additional aspect of pathogenesis.90,91 These agents are used only systemically and include
tetracycline, minocycline and doxycycline. Through calcium chelation, they inhibit neutrophil and
monocyte chemotaxis; minocycline and doxycycline are 10 times more active than tetracycline.
Concentrations below the antibiotic threshold still inhibit inflammation and improve both acne vulgaris and
acne rosacea. Resistance is lower with tetracyclines than with erythromycin or clindamycin; cross-
resistance occurs between tetracycline and doxycycline but not minocycline.90 In practice, minocycline
appears more effective than doxycycline and is effective in patients who do not respond to doxycycline.90
This may be due to greater lipophilicity; there is a tenfold greater reduction of P. acnes by minocycline
compared with doxycycline.91 However, a Cochrane review showed that although minocycline is an
effective treatment for moderate to severe inflammatory acne, there is little evidence to support its
superiority to other tetracyclines.92 There is no conclusive clinical difference although it is more lipophilic,
may act more quickly and can be taken once daily. Doxycycline and minocycline differ in side effect
profiles. Doxycycline is a photosensitizer, especially at higher doses. Minocycline may cause dose-related
dizziness, which resolves with dosage titration. People treated with minocycline are at significantly greater
risk of developing an autoimmune syndrome than those receiving tetracycline or no treatment.
Hypersensitivity reactions include urticaria, serum sickness–like reactions and generalized drug-induced
reactions resembling lupus.90
Other antibiotics sometimes useful in acne include azithromycin, ciprofloxacin and

sulfamethoxazole/trimethoprim, but these should be reserved for patients who do not respond to
conventional treatment.62,93,94
Dapsone, a synthetic sulfone, is an anti-inflammatory agent effective for acne when given orally, but not
used due to risk of serious systemic side effects. A topical gel formulation of dapsone is now available
and currently does not appear to pose the risks associated with systemic dapsone use. Sulfones have
both anti-inflammatory and antimicrobial properties that improve both inflammatory and noninflammatory
acne, with more prominent effects occurring in inflammatory lesions. Short and long-term safety have
been demonstrated.95,96,97,98 One study showed dapsone gel may be more effective in women than
men.99 It also appears to be safe and effective in combination with adapalene and benzoyl
peroxide.100,101 Topical dapsone is a novel addition to the treatment armamentarium especially for
patients exhibiting sensitivities or intolerance to conventional antiacne agents.
Strategies to limit antibiotic resistance are important in acne management. Oral and topical antibiotics
should not be used as monotherapy.75 Concurrent use of oral and topical antibiotics should be avoided,
particularly if chemically different, due to increased risk of bacterial resistance. The use of systemic
antibiotics should be limited (both indication and duration). Patients with less severe forms of acne should
not be treated with oral antibiotics, and where possible such therapy should be limited to the shortest
feasible duration. Avoid use of antibiotics for maintenance therapy. Discontinue antibiotics when there is
no further improvement or the improvement is only slight. Oral antibiotics should ideally be used for 3
months, but response to antibiotics should be assessed 6–8 weeks into treatment. Nearly 70% of patients
with acne require antibiotics for 12 weeks or less if aggressive retinoid therapy is used during that time;
therefore, early use of combination therapy with retinoids is encouraged. The complementary modes of
action of antimicrobials plus retinoids result in increased speed of response, greater clearing and
enhanced efficacy against comedones and inflammatory lesions. If patients relapse, use the original
antibiotic for subsequent courses unless there is adequate justification for a change. In addition,
isotretinoin use should be initiated earlier in indicated patients, rather than prolonging antibiotic courses.90
Prolonged oral administration of antibiotics may cause overgrowth of gram-negative organisms, producing
a refractory folliculitis and necessitating discontinuation. Adding benzoyl peroxide to oral or topical
antibiotic therapy will also reduce development of antibiotic resistance.75
Other Systemic Agents
Antisebum agents: No topical agents directly influence the production of sebum. Systemic drugs that
influence sebum production include estrogens, antiandrogens (drospirenone, cyproterone acetate),
spironolactone and the retinoid isotretinoin.
Oral contraceptives (OCs) are effective for the treatment of acne102 and several are indicated for this
purpose in Canada. OCs with minimal androgenic effects (see Contraception) and those containing the
antiandrogens cyproterone acetate or drospirenone are especially useful in women with other signs of
androgen excess. OCs showed equivalent efficacy to oral antibiotics in one meta-analysis.103 There is a
small risk of venous thromboembolic events with the use of any combined OC.104,105,106 This risk is
slightly higher with those that contain cyproterone or drospirenone.105,106,107 Therefore, consider
cyproterone- or drospirenone-containing OCs when other OCs are ineffective or not tolerated.
Spironolactone is also used as a form of antiandrogenic hormonal therapy for acne in some patients.
Isotretinoin is the only drug treatment for acne that produces prolonged remission. It is recommended as
first-choice therapy for severe papulopustular or moderate nodular acne and for nodular or conglabate
acne for many reasons: clinical effectiveness, prevention of scarring and quick improvement of a patient’s
quality of life, including minimizing depression.3,75 Although comparative trials are lacking, clinical
experience confirms relapse rates after isotretinoin treatment are the lowest among available therapies.
Additionally, it is recommended for management of less severe acne that is treatment-resistant
(unresponsive to adequate treatment, reasonable courses of antibiotic, or combination peelers and
antibiotics administered for 6 weeks to 3 months) or that is producing either physical or psychologic
scarring. The risk of potential side effects must be weighed against its ability to prevent lifelong and
permanent physical and psychological scarring.
Oral isotretinoin is a natural metabolite of vitamin A. Its mechanism is elusive, as it does not bind to
retinoid receptors. It has been shown to reduce sebogenesis and may also inhibit sebaceous gland
activity, growth of P. acnes and inflammation, and improve follicular epithelial differentiation. Systemic
isotretinoin exerts a primary effect on comedogenesis, reducing size and formation of new comedones.
Conventional dosing is 0.5–2 mg/kg/day for 12–16 weeks. Initiating with a low dose and titrating will
minimize transient exacerbation of acne at the start of therapy. Some patients experience a relapse of
acne after the first course of isotretinoin: a second course may be used starting at least 8 weeks after the
end of the first course (as acne may continue to improve during this time). Studies have shown that other
dosing regimens (low-dose, intermittent) may also be effective.108,109,110
Because isotretinoin is a vitamin A derivative, it interacts with many of the biologic systems of the body,
and consequently has a significant pattern of adverse effects. The pattern is similar to that seen in
hypervitaminosis A. Side effects include those of the mucocutaneous (most common), musculoskeletal
and ophthalmic systems, as well as headaches and CNS effects. Most adverse effects, such as cheilitis
and dry nose, eyes and mouth, are temporary and resolve after the drug is discontinued. Replace any
concurrent topical products that produce a drying effect with moisturizers. Laboratory monitoring during
therapy should include triglycerides, cholesterol, transaminases and complete blood counts.
Mood disorders, depression, suicidal ideation and suicides have been reported sporadically in patients
taking this drug. Evidence is insufficient to support a causal association. These symptoms are common in
patients with acne and in adolescents and young adults, who represent the majority of patients receiving
isotretinoin. Prescribers of isotretinoin are advised to note prior psychiatric symptoms, monitor patients at
each visit for early recognition and advise patients about a possible risk of depression and suicidal
behaviour. This disputed association remains an important area for future research.111,112
The teratogenic effects of oral retinoid therapy are well documented. Women must start contraceptive
measures 1 month prior to treatment, continue for the duration of treatment and for 1 month after
stopping treatment with isotretinoin.
Treating Sequelae of Acne
Pigmentation: Postinflammatory pigmentation is a common consequence of acne that may persist up to 2

years after lesions have resolved. To control this pigmentation, hydroquinone, which reversibly damages
melanocytes, has been used as a hypopigmenting agent in concentrations of 2–4%, in preparations of
clear or tinted gels (which are more drying), and as vanishing or opaque, flesh-tinted creams, with or
without alpha-hydroxy acids or sunscreens. Hydroquinone causes fading of epidermal (but not dermal)
pigmentation. Onset of response is usually 3–4 weeks, and the depigmentation lasts for 2–6 months.
After considering additional data and information on the safety of hydroquinone, the FDA issued a
proposed ruling in 2006 stating that nonprescription serums and lotions containing hydroquinone are not
generally recognized as safe and effective and are misbranded. The FDA also intends to consider all
prescription hydroquinone products to be new drugs requiring an approved new drug application for
continued marketing. Hydroquinone has already been banned in Japan, much of the European Union and
Africa. While effective in the removal of melanin, hydroquinone may be a carcinogen and causes a blue-
black discoloration known as ochronosis.113
Scarring: Many patients have acne scarring despite adequate treatments. Atrophic scars can be treated
with laser resurfacing. For patients with mild scarring, alpha-hydroxy acids may be used, while severe
scarring may be corrected with other treatment modalities that require a dermatologist consultation.
Dermabrasion, chemical peels (e.g., 70% glycolic acid) and laser therapy have been used. Usually the scar
is not completely removed, but a more cosmetically acceptable result is achieved.25 Keloids and
hypertrophic scars can be treated with intralesional triamcinolone, cryotherapy, topical corticosteroids and
silicone sheeting.6 Surgical options for scars include excision, augmentation with collagen or fat,
subcision and injection of autologous fibroblasts.2
For more information on prescription therapy, consult the Compendium of Therapeutic Choices: Acne.
A systematic review of complementary and alternative medicines (CAMs) for acne concluded that there is
some low-quality evidence from single trials that tea tree oil and bee venom may reduce total skin lesions
in acne. The same review cautioned that there is a lack of evidence to support the use of other CAMs such
as aloe vera, copaiba essential oil, dried fruit of Berberis vulgaris, seaweed oligosacchrides, acupuncture or
wet-cupping in the treatment of acne.26 Natural health products can cause adverse effects; future studies
need to assess safety. Methodological and reporting quality limitations weaken any evidence. The use
nonstandardized botanical preparations should be discouraged in favour of traditional quality-controlled
preparations that have evidence of efficacy.
Common Drug Therapy Problems with Acne
Indiscriminate use of topical applications: failure to use systemic treatment when indicated
Prolonged treatment with antibiotics when unnecessary or ineffective
Wrong choice of drug
Failure to use combination therapy
Improper application of active drug
Drug side effects
Table 4 provides a monitoring framework for patients with acne.
Parameters should be monitored by the patient in a diary. Therapy should be appropriately tapered in
response to improvement or resolution. The healthcare practitioner should be responsible for ensuring that
the treatment plan remains on schedule and is effective, and that no adverse effects are occurring.
Patient Education
Acne is usually considered self-limiting in that it begins in the teenage years and usually subsides in the mid
to late twenties. However, for some it evolves into a chronic condition. Symptoms can be managed with
diligent and long-term treatment, focused on control and prevention, if proper education is provided. However,
acne is poorly understood by adolescents in terms of many issues: identifying the cause of the disorder and
aggravating factors, indications for self-care vs. prescription treatment, concerns regarding safety and
duration of treatment and appropriate application of topicals. Review the patient's understanding of each of
these important factors in ensuring patient adherence. There is often a need to supplement counselling
sessions with written materials that the patient can refer to at home. Both written handouts and audiovisual
computerized presentations about acne conferred significant and equivalent benefits in terms of short- and
long-term knowledge gains among adolescent patients with acne.114 Electronic reminders in the form of daily,
customized text messages were not associated with significant differences in adherence to topical
medications in patients with mild to moderate acne and had no significant effect on therapeutic response.115
Table 4: Monitoring of Therapy for Acne

Parameter Timeframe/Degree of Change Actionsa
Short-term Effectiveness Endpoints (Acne resolution/control)
Lesion count Decrease by 10–25% within 4–8 wk, with If endpoints not achieved,
control, or more than a 50% decrease consider further therapy.
within 2–4 months.
Comedones Resolve by 3–4 months.
Inflammatory lesions Resolve within a few wk.
Anxiety or depression Achieve control or improvement within

2–4 months.
Long-term Effectiveness Endpoints
Progression of severity No progression of severity. If endpoints not achieved,

consider further therapy.
Recurrent episodes Lengthening of acne-free periods
throughout therapy.
Scarring or pigmentation No further scarring or pigmentation

throughout therapy.
Safety Endpoints (treatment side effects)
For each nondrug or drug measure initiated, list the side effect (safety endpoint) most likely to occur,
the degree to which it might be tolerated, if at all, and within what timeframe it might be expected.
Indicate how the side effect would impact therapy, i.e., continue and monitor, continue and treat side
effect, continue but decrease dose, or discontinue therapy and choose alternative.
a Advise patient to monitor each parameter daily while on drug therapy. Healthcare practitioners should monitor each
parameter every 4–8 weeks during therapy (or at next visit).
Algorithms
Figure 3: Assessment of Patients with Acne
a Noninflammatory (open/closed comedones)/inflammatory (papules, pustules, nodules/cysts).

b Typical ages 12–25 years; onset after puberty may signal acne rosacea.
c Baby oil should be avoided as it may aggravate follicular occlusion.
Figure 4: Treatment of Acne with Nonprescription Medication
a For more information on the management of acne, consult Compendium of Therapeutic Choices: Acne.
Drug Table
Table 5: Nonprescription Agents Used to Treat Acnea
Class Drug Dosage Onset Adverse Comments Costb
Effects
Antibacterial/exfoliant benzoyl Apply Antibacterial Produces Cross- $
peroxide daily or effect: mild sensitivity
2.5–10% BID Onset: Rapid; irritant with balsam
Benzagel, number of dermatitis. of Peru,
Proactive, inflamed Dryness cinnamon
others lesions could and and other
decrease peeling benzoic acid
within 5 appear derivatives
days. after a few (topical
days. anesthetics).
Duration:
Bactericidal Contact
effect lasts allergic
for at least dermatitis.
48 h. May
Exfoliant bleach
effect: hair or
fabric.
Onset: Must
be used for Odour
8–12 wk remains
before on
improvement clothing
noted. and bed
sheets.
Duration of
treatment is
long term.
Dosing
schedules
adjusted
PRN for
chronic
control.
Taper off
until natural
resolution.
Exfoliant glycolic Apply Some effect Irritating $$

acid 2–15% BID may be seen
Neostrata, in 6–7 wk.
Reversa,
others
Exfoliant salicylic Apply Must be Initial Increases $

acid 0.5– daily or used for 8– irritation. penetration
2% BID 12 wk before 3–6% is of other
Clean and improvement keratolytic, active
Clear noted. causing ingredients.
Moisturizer, Duration of softening
Clearasil treatment is of horny
Wash, long term. layer.
others
a For more information on drug therapy for acne, consult the Compendium of Therapeutic Choices: Acne.
b Cost of smallest available pack size; includes drug cost only.
Legend: $ <$10 $$ $10–20
Suggested Readings
Suggested Readings
Asai Y, Baibergenova A, Dutil M et al. Management of acne: Canadian clinical practice guideline. CMAJ 2015.
DOI:10.1503 /cmaj.140665
Eichenfield LF, Krakowski AC, Piggott C et al. Evidence-based recommendations for the diagnosis and
treatment of pediatric acne. Pediatrics 2013;131:S163-86.
Nast A, Dréno B, Bettoli V et al. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad
Dermatol Venereol 2012;26:1-29.
Sibbald D. Acne. In: DiPiro JT, ed. Pharmacotherapy: a pathophysiologic approach. 9th ed. New York: McGraw-
Hill; 2013.
Thiboutot D, Gollnick H, Bettoli V et al. New Insights into the management of acne: an update from the Global
Alliance to Improve Outcomes in Acne Group. J Am Acad Dermatolog 2009;60:S1-50.
Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet 2012;379:361-72.
References
1. Leyden JJ, Shalita AR. Rational therapy for acne vulgaris: an update on topical treatment. J Am Acad
Dermatol 1986;15:907-15.
2. Batra RS. Acne. In: Arndt KA, Hsu JTS, eds. Manual of dermatologic therapeutics. 7th ed. Philadelphia:
Wolters Kluwer/Lippincott Williams & Wilkins; 2007. p. 1:3-18.
3. Nast A, Dreno B, Bettoli V et al. European evidence-based (S3) guidelines for the treatment of acne. J
Eur Acad Dermatol Venereol 2012;26:1-29.
4. Shalita AR. Genesis of free fatty acids. J Invest Dermatol 1974;62:332-5.
5. Tucker SB, Rogers RS, Winkelmann RK et al. Inflammation in acne vulgaris: leukocyte attraction and
cytotoxicity by comedonal material. J Invest Dermatol 1980;74:21-5.
6. Chu A. Acne vulgaris. In: Lebwohl MG, Heyman WR, Berth-Jones J et al., eds. Treatment of skin
disease: comprehensive therapeutic strategies. 2nd ed. Philadelphia: Mosby Elsevier; 2006. p. 6-12.
7. Winston MH, Shalita AR. Acne vulgaris. Pathogenesis and treatment. Pediatr Clin North Am
1991;38:889-903.
8. Plewig G, Kligman AM. The dynamics of primary comedo formation. In: Plewig G, Kligman AM, eds.
Acne: morphogenesis and treatment. New York: Springer-Verlag; 1975. p. 58-107.
9. Puissegur-Lupo ML. Acne vulgaris. Treatments and their rationale. Postgrad Med 1985;78:76-80, 83-4.
10. Layton AM, Henderson CA, Cunliffe WJ. A clinical evaluation of acne scarring and its incidence. Clin
Exp Dermatol 1994;19:303-8.
11. Thiboutot DM. Acne. An overview of clinical research findings. Dermatol Clin 1997;15:97-109.
12. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug
Evaluation and Research (CDER). Guidance for industry. Acne vulgaris: developing drugs for treatment.
September 2005. Available from: www.fda.gov/downloads/Drugs/.../Guidances/UCM071292.pdf.
13. Katsambas AD, Katoulis AC, Stavropoulos P. Acne neonatorum: a study of 22 cases. Int J Dermatol
1999;38:128-30.
14. Williams M, Cunliffe WJ. Explanation for premenstrual acne. Lancet 1973;2:1055-7.
15. Strasburger VC. Acne. What every pediatrician should know about treatment. Pediatr Clin North Am
1997;44:1505-23.
16. Taylor JS. Chloracne: a continuing problem. Cutis 1974;13:585.
17. Rosenberg EW, Kirk BS. Acne diet reconsidered. Arch Dermatol 1981;117:193-5.
18. Fulton JE, Plewig G, Kligman AM. Effect of chocolate on acne vulgaris. JAMA 1969;210:2071-4.
19. Anderson PC. Foods as the cause of acne. Am Fam Physician 1971;3:102-3.
20. Kim J, Ko Y, Park YK et al. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid
and clinical improvement of acne vulgaris. Nutrition 2010;26:902-9.
21. Adebamowo CA, Spiegelman D, Danby FW et al. High school dietary dairy intake and teenage acne. J
Am Acad Dermatol 2005;52:207-14.
Acne—What You Need to Know
Acne is a common skin disorder that affects most adolescents and some adults. Acne generally appears as pimples or larger
pustules on the face, chest, back and upper arms. Severe acne may cause scars. Acne usually goes away by the time a
person becomes an adult. However, having acne causes emotional difficulties for many people.
What causes acne?
Acne is not caused by dirt. Washing your face too often can irritate your skin and may make your acne worse.
Wash your skin gently from the jawline to the hairline no more than twice daily with water alone or a mild,
nonalkaline soap or soapless cleanser. Do not rub or scrub your skin and avoid rough washcloths.
Acne is not caused by eating chocolate or greasy foods. However, you should try to eat a healthy, balanced diet,
including fruit and vegetables. Cut down on fatty treats for your general health and choose low-glycemic
options.
Stress can make acne worse. Try to reduce stress through exercise or relaxation.
Some medications and chemicals can cause acne. Talk to your healthcare provider if you have to take medicine
daily or if you are exposed to chemicals at work.
How do you treat acne?
Treat acne as soon as it appears to avoid complications such as scarring. Many different acne medications are
available without a prescription.
Ask a healthcare provider for advice about nonprescription acne medication. Some can irritate your skin or
make your acne worse for a short time. Use the medication only once a day until your skin gets used to it.
Use a nonprescription acne medication for 6–8 weeks. Remember, it may take some time before your skin looks
better. Try not to get discouraged!
Apply acne medication everywhere you have pimples. The medication will work better if you cover all the
affected skin, not just the pimples. Use a clean cotton pad for each area that you are going to treat. Throw the
pads away after using once.
See your healthcare provider if
you have a lot of acne (pimples or large pustules).
you suspect your acne is being caused by a medical condition or by medicine that you have to take.
your acne has not improved after using nonprescription medication for 6–8 weeks.
you have a sudden change in the appearance or number of acne lesions.
Some Helpful Hints
Do not use greasy cosmetics, coverstick, moisturizer, hair gel, scalp oil, eye cream or hairspray. All of these
products can make your acne last longer—even if you only use them once.
Do not use makeup regularly. If you must use makeup, choose an oil-free product that has the words
“noncomedogenic” or “nonacnegenic” on the label. These words mean that the product will not cause acne.
Remove all makeup carefully at bedtime.
Wash your hair regularly. If you have oily hair, wash it more often. Keep your hair off your face as much as
possible. Tie it back while you sleep.
Do not pick, scratch, pop or squeeze your pimples. Cupping the chin in a hand can cause acne. It is best not to
touch your skin at all if you can avoid it. If you have the habit of touching your skin, try to decrease this habit.
You may want to keep a daily record of when you touch your skin to help you break this habit.
Blackheads or whiteheads (comedones) can be removed with a “comedone extractor” (a tool to help press the
blackhead out). The small end of a plastic eye dropper, without the bulb part, may also work. After cleaning the
area with hot water, the comedone extractor is placed over the blackhead or whitehead and gentle pressure is
applied until the contents are pressed out. This removes the blackhead or whitehead and may prevent it from
becoming inflamed. If gentle pressure is not enough to remove the comedone, do not continue, as you will
irritate the skin. Clean the comedone extractor with alcohol after each use. Blackheads and whiteheads may
come back 25–50 days after removal. Treating the area of comedones with a peeling product for 4–6 weeks
before using the comedone extractor may give a better result.
If you shave, try both an electric razor and a safety razor to see which is more comfortable. If you use a safety
razor, soften your beard with soap and warm water before you shave. Try to shave less often. Always use a
sharp blade and shave lightly. Shave over each area only once in the direction the hair grows.
A tan can hide acne, but tanning can also damage your skin. To protect your skin, use an oil-free sunscreen with
a sun protection factor (SPF) of at least 15. An alcohol lotion or gel sunscreen is the best form for your skin.
There are 2 main kinds of sunscreen: chemical and physical. Chemical sunscreens must be absorbed by the
skin to be effective, so they should be applied after cleansing but before acne medication. Physical sunscreens
(containing zinc or titanium) remain on the surface of the skin to reflect the sun and may stop acne medication
from being absorbed (and being effective) if they are applied first, therefore, physical sunscreens should be
applied after acne medication. If your acne medication contains benzoyl peroxide, do not use it at the same
time as a sunscreen. Apply the sunscreen during the day and the benzoyl peroxide at night.
Avoid humid environments.
Wear clothing that allows the skin to breathe.
Avoid or reduce exposure to environmental factors, such as dirt, dust, petroleum products, cooking oils or
chemical irritants.
If your skin is irritated by a headband, violin, chin strap, guitar strap or orthopedic braces, try cutting a sterile
cotton pad to fit underneath.
Avoid sports equipment such as sports helmets that rub against the skin with friction. If not possible, wear
clean absorbent cotton garments or padding underneath equipment or uniforms.
Follow these suggestions as long as you have acne. Remember to see your healthcare provider if the acne does
not improve after 6–8 weeks of treatment.
Atopic, Contact, and Stasis Dermatitis

Introduction
Dermatitis is a nonspecific term describing both acute and chronic skin reactions with corresponding clinical patterns
and history. Although the word eczema (boiling over) has been used synonymously with atopic dermatitis, most
dermatologists use the term dermatitis to describe an acute, nonspecific skin reaction that exhibits swelling,
erythema, scaling, vesicles and crusts. Atopic dermatitis is a chronic inflammatory skin disease caused by
mucocutaneous barrier dysfunction. Contact dermatitis is an inflammatory skin reaction caused by exposure to
allergens or irritants. Stasis dermatitis is inflammation of the skin of the lower legs caused by chronic venous
insufficiency.
Skin changes in dermatitis reflect the pattern of inflammatory response. The appearance is similar in all forms of
dermatitis, regardless of cause.
When the reaction is acute, the earliest and mildest changes are erythema (redness) caused by engorgement and
dilatation of the small blood vessels and, usually, swelling (edema) resulting from leakage of fluid from blood vessels
and accumulation in tissues. If swelling is severe, skin cells form vesicles that fill with edema fluid; this process is
called vesiculation or blistering. Breakage of blisters results in oozing or weeping and evaporation of this fluid causes
crusting and scaling.
Dermatitis may progress to a chronic stage where the skin becomes dry, fissured and cracked. With prolonged itching
and scratching it thickens, and the normal skin markings become more prominent. This process is called
lichenification. The skin may show damage from scratching (linear or punctate scarring) and hyperpigmentation or
hypopigmentation.1
Pathophysiology
Atopic Dermatitis
Atopic dermatitis, allergic rhinitis/conjunctivitis and allergic bronchial asthma belong to the atopic syndrome, or
atopic diathesis, which is a mucocutaneous barrier dysfunction.2 Atopic dermatitis is a chronic inflammatory skin
disease associated with cutaneous and mucous membranes hyper-reactivity to environmental triggers that are
innocuous to nonatopic individuals.3 Atopic dermatitis affects 10–20% of the population. The disease is
genetically associated, with a risk of 70% if both parents are afflicted, and a higher risk of inheritance from mother
than father. While the genetic link may contribute to increased incidence in Asians or black Caribbeans, this is
evident only if living in dry, cold climates.4 It is significantly more common in those of higher socioeconomic
status, children from small families and those who live in privately owned properties, possibly reflecting the
influence of lifestyle, home furnishing and education.4
Eighty to 85% of patients with atopic dermatitis have high levels of total IgE, which correlate with the severity of
clinical disease. Children with mild to moderate disease have much lower levels than those with severe disease.5
The IgE trigger causes an eczema-type reaction rather than a classic urticarial reaction. Eosinophils are involved in
producing pro-inflammatory products in the skin and mucous membranes. Twenty percent of patients show
normal IgE levels and lack specific sensitization against inhalant and food allergens. Genetic impairment of the
epidermal barrier has been proposed as a cause of atopic dermatitis. Evidence supports the classical concept of
atopic dermatitis as a continuum that begins with impaired epidermal barrier and penetration of environmental
factors causing eczema in about 20% of individuals, primarily female and with normal IgE. Sensitization to
allergens and infections progresses to atopic dermatitis, leading to scratching and ensuing tissue damage. This
causes sensitization to self-proteins and the “autoallergic” stage of atopic dermatitis which is associated with high
levels of IgE and the concomitant risk of development of asthma.6
Atopic dermatitis is predominantly a disease of childhood.4 It begins in infancy but is rarely present at birth, and
decreases in intensity with age. In approximately 80% of cases the problem develops during the first year of life,
and in up to 90% of cases the onset occurs before 5 years of age.7 In children younger than 2 years, there may be a
stronger male-to-female ratio, but this is reversed after age 2, with a slight female preponderance. Increased
disease chronicity in females may be responsible.4 Incidence of occupational allergic and irritant contact
dermatitis is increased in patients with atopic dermatitis. In adults and children, Staphylococcus aureus
colonization is high, whereas adult skin is more heavily colonized with Malassezia yeasts.8
Contact Dermatitis
Contact dermatitis is a pattern of inflammatory responses in the skin that occurs through contact with external
factors. The clinical picture is a polymorphic pattern of skin inflammation characterized by a wide range of clinical
features, including itching, swelling, redness and scaling. Contact dermatitis is a common occupational disease
and is also caused by cosmetics, skin care products and other chemicals such as textile dyes in clothing and
outdoor plants. Aggravating factors play a large role since the extent and severity varies with: the frequency and
duration of exposure; presence of infected, inflamed or burned skin; degree of allergic sensitivity and mechanical
factors such as pressure, friction and excessive perspiration, which may intensify the dermatitis.9 Extremes in
temperature, humidity, sweating and occlusion can lower the threshold for irritation.10 Secondary infection with
bacteria or fungi is more likely in dermatitic skin.10
Contact dermatitis occurs from infancy onwards and is divided into 2 categories: allergic contact dermatitis (20%
of patients) and irritant contact dermatitis (80% of patients). Lower incidence among children is due to limited
exposure to allergens.11
Allergic contact dermatitis is a delayed or T cell-driven hypersensitivity immune reaction mediated by lymphocytes
previously sensitized by exposure to contact allergens, or haptens. Allergenic substances must be processed
within the epidermis by the Langerhans cells that migrate to regional lymph nodes. Here, antigen is conjugated
with proteins processed by T lymphocytes, which become specifically reactive to the presented antigen, initiating a
sequence of cytokine-mediated events and inflammatory response.12 The reactivity of the skin is a result of
balance between T lymphocyte hypersensitivity and suppressor cells which invoke allergen tolerance.12 Most of
these cellular reactions produce sensitization in only a small percentage of those exposed. The incubation period
after initial sensitization is 5–21 days and 12–48 hours after subsequent re-exposure, but the reaction may
continue to develop for several weeks.9 Predisposition to develop allergic contact dermatitis is genetic. Allergic
contact dermatitis decreases with age since the skin of people over 65 is less reactive to allergens, due to
diminished immune function that occurs with age.11 However, older patients also have impaired epidermal barrier
function and slower skin recovery after an insult. In the elderly, eczematous erythroderma (severe widespread
redness of the skin) is common.13 Elderly patients may acquire allergy to topical preparations used to treat stasis
or contact dermatitis.14
Primary irritant contact dermatitis is a nonallergic reaction resulting from activation of the innate immune system
by the direct cytotoxic effect produced by exposure to any substance including chemical, physical or biologic
agents, if the concentration and duration of contact are sufficient. Mild irritants such as soaps, detergents and
most solvents require repeated or sustained contact to produce inflammation. Strong irritants such as acids and
alkalis may injure the skin immediately. Irritant effects may be considerably enhanced by occlusion. The majority of
cases are related to occupation, in particular jobs that involve work with water or exposure to irritant substances.
Hand dermatitis results from frequent washing of the hands which damages the skin through a combination of
mechanisms: increased skin permeability from alkali-induced damage to the keratin, removal of lipids and amino
acids from the skin, and alteration of the skin's buffering capacity. Intensification may also be produced by irritants
such as waxes, polishes and turpentine and through excoriation or rubbing.12 Hand dermatitis may affect 1 in 9
adults in any given year, predominating in females with a ratio greater than 5:1.15 Diaper dermatitis is common and
is discussed in Diaper Dermatitis.
Stasis Dermatitis
Stasis dermatitis results from chronic venous insufficiency and is commonly seen in middle-aged or elderly
patients, more frequently in women than in men. Approximately one-third of patients have a previous history of
deep vein thrombophlebitis related to trauma, pregnancy, surgery or prolonged illness.9
Goals of Therapy
Eliminate individual trigger factors or contact exposure to irritants and allergens
Restore barrier function
Provide symptomatic relief while decreasing skin lesions
Implement preventive measures focusing on decreasing the number of episodic flares, lengthening symptom-
free periods and prevention of excoriations
Develop coping strategies and expectations for patients/caregivers
Patient Assessment
The pattern of dermatitis and its trigger factors influence the clinical classification and therapy. An approach to
assessing patients with dermatitis is shown in Figure 1.
Atopic Dermatitis
Atopic dermatitis presents as an intensely pruritic acute, subacute or chronic eruption seen in characteristic
patterns in infants, children and adults. The diagnosis is purely clinical; the symptoms and signs of atopic
dermatitis are numerous, but usually nonspecific. Itch is the main symptom. There is no primary skin lesion in
atopic dermatitis; the clinical presentation of eczematous skin lesions represents skin changes induced by
constant scratching and excoriations.16 The skin is typically dry and the lesions scaly, though they may be
vesicular, weeping or oozing in the acute stage. Clinical presentation supports both debated theories as to the
chronology of pruritus and lesions: itch may precede visible skin lesions and/or erythema, and inflammation
may evoke pruritus.17 Various triggers such as stress result in appearance of erythema followed by itch, then
vasodilation and inflammation due to scratching. The pruritus may be focal or generalized if skin is dry and may
be most intense during the evening and at night. It is usually intermittent and leads to vigorous itch-scratch
cycles, commonly with secondary bacterial infection of excoriated lesions.9
Although atopic dermatitis can affect any area of the body, it preferentially affects the flexures and the face.
Distribution of lesions depends on the age of the patient, with infantile, childhood, adolescent and adult phases.
In babies aged less than 6 months, the face and scalp are the sites most commonly affected, and redness and
chapping of a baby's cheeks can be the earliest sign.3 This chapping usually begins at 2–3 months and
persists for 2 years. Remission usually occurs between 2 and 4 years of age. Subsequently, a chronically
relapsing dermatitis begins, located on the extensor sides of the extremities but also on the flexural areas. The
most common sites are the antecubital and popliteal fossae.3 It can also be located around the mouth, eyelids,
neck and hands. The lips can be dry and scaly. Visual signs of chronic atopic dermatitis include less redness,
increased dryness and early lichenification (thickened skin, hyperpigmentation and accentuation of skin
furrows due to repeated rubbing and scratching). Involvement of the back of the arms and the front of the legs
is seen first, and later a transition occurs to the elbows and knee folds. Frictional areas such as wrists and
ankles are regular sites, and localization may occur to the toes. Occlusive footwear causing excessive sweating
and drying of the feet may exacerbate the condition. Children aged 4–6 years usually develop symmetric
eczema on flexural areas, hands, feet, and the back of the thigh. As the child reaches adulthood, recurrent
outbreaks diminish or disappear. In adolescents and adults, the involvement may be generalized, but flexural
accentuation is the hallmark of clinical disease. Adults typically exhibit lesions on the face, upper body and
flexural areas.18
In addition to the classical patterns, there are site-specific variants. Eyelid eczema is common in 21% of
adolescents and is associated with hay fever and exposure to aeroantigens such as house dust mites. The
infra-auricular and retro-auricular sites of the ears are particularly prone to fissuring, as a reaction to minor
trauma.3
Areas of predisposition may be related to the thickness of the stratum corneum and variations in exposure to
irritants and allergens at different body sites: thinnest areas are genitals and eyelids, often subject to rubbing,
followed by flexor forearms and posterior auricular.3 Other parts of the face and flexures have a thin epidermal
barrier with decreased barrier function. In the areas most vulnerable to penetration, the disease persists
longer.3
Other minor features exhibited by atopic patients include recurrent conjunctivitis, cheilitis (chapped lips),
infraorbital folds (Dennie-Morgan lines), recurrent infections (especially viral) and impaired cell-mediated
immunity.16 See photo, Atopic Dermatitis.
The diagnosis of atopic dermatitis is based on essential and supporting features. Essential features must be
present and include pruritus and dermatitis (typical morphology, age-specific features and chronic or relapsing
history). Supporting features are present in most cases and include early onset, family history and high IgE
reactivity. Other associated features are too nonspecific to be diagnostic. Conditions which must be included in
the differential diagnosis are: scabies, contact dermatitis, ichthyosis, cutaneous T-cell lymphoma, psoriasis,
photosensitivity, immune deficiency and erythroderma due to other causes.19
Photo 1: Atopic Dermatitis
Genetics: Atopic dermatitis patients have an increased personal or family history of atopic syndrome, including
type 1 allergies (immediate hypersensitivity), hay fever, asthma and chronic allergic rhinitis/conjunctivitis and
are genetically predisposed.19
Environmental Allergens: Excessive use of soaps, detergents and shampoos irritate the skin and disturb the
skin barrier. Alcohol and astringents in skin care products can be drying and their use should be limited.20
Central heating, insulation, air conditioning and inadequate ventilation may increase exposure to environmental
antigens such as house dust mites, molds, pollens and furry pets. Global warming and increased use of
fertilizer may enhance density and allergenic potency of pollen from trees and grains.2 The influence of these
environmental and lifestyle factors may account for increased incidence in individuals of higher socioeconomic
status.4
Climate: The influence of climate is shown in Asians with atopic syndrome who live in humid tropical climates
and do not manifest cutaneous symptoms until they move to colder, drier countries.2 A seasonal variation is
due to several contributing factors: environmental allergens cause relapses in summer, while climatic
influences may cause clearing in summer sun and worsening in the dry, cold air of winter. Dryness of the skin
(xerosis) with water content below 10% is crucial for induction of itch and scratching.17 Heat worsens the skin
condition.
Sweating: Any stimulus to sweating (thermal, emotional) is a typical hallmark and the most common trigger of
itch. Acetylcholine may be involved and there may be a decreased threshold for sweat stimulation.17
Physiologic Stress: Stress associated with demanding modern lifestyles appears to enhance skin irritability and
contributes to the itch-scratch cycle and sleep disturbances.7,2 The alteration in skin appearance due to
scratching escalates the emotional reaction to coping with the disease.21
Dietary Influences: Although patients with atopic dermatitis are more likely to have food allergies, food
ingestion as a causal factor in atopic dermatitis flares is uncommon. Current evidence does not support
eliminating cow's milk from the diet to improve atopic dermatitis. Some evidence suggests that elimination of
eggs might benefit patients with atopic dermatitis who have suspected egg allergy and are sensitized to eggs,
but more research is needed.22 More detailed information about this controversy is documented in the
literature.23,24,25,26,27 See also Nonpharmacologic Therapy.
Irritants: Disinfectants, solvents and allergens in skin care products play an important role. Issues of irritation
extend to clothing fabrics and products. Intolerance to wool is a hallmark of atopy. Coarse-textured fabrics,
liquid or sheet fabric softeners (which cause fibres to plump up and stay erect) and bleach should be avoided.
Infections: Atopic patients have an increased propensity for cutaneous viral infections including herpes
simplex, molluscum contagiosum and warts, fungal infections such as dermatophytosis, pityriasis (tinea)
versicolor and candidiasis, and bacterial infections such as S. aureus.25
Itch-scratch cycle: Severe pruritus elicits reflexive scratching, resulting in a vicious cycle of itch and scratch.
Contact Dermatitis
Cutaneous responses are dependent on the particular chemical, the duration and nature of the contact, and
individual host susceptibility. Despite different pathogeneses, the allergic and irritant forms have similar clinical
appearances, especially in the chronic forms. The clinical presentation of contact dermatitis is determined by
the severity and acuteness of the inflammation. The area involved usually reflects the pattern of the contacting
substance and may have sharp, well-demarcated linear margins or unusual geographic shapes. It may spread
to distant sites through lymphocytes. Contact substances may be transferred from the primary site by touch to
distant areas, especially the eyelids and neck, which are very reactive sites. The face may display a reaction to
substances applied to the scalp. Allergic contact dermatitis and irritant contact dermatitis are predominant
causes of periorbital dermatitis.28 Scalp, palms and sole areas are more resistant. The distribution of the
lesions may provide clues to the irritant or allergen trigger.
Acute reactions are often red, edematous papules in the early phase, which become vesicles and bullae that
ooze if the reaction is severe enough. Chronic reactions produce an entirely different clinical picture in which
primary lesions are minimal, and secondary changes such as dryness, lichenification, pigment changes,
hyperkeratosis or thickening, excoriation and fissuring predominate. As with other forms of acute and chronic
dermatitis, itching is the primary symptom.29
Irritant Contact Dermatitis: Acute irritant contact dermatitis reactions usually reach their peak within minutes to
hours after exposure and then start to heal. Symptoms of an acute reaction to mild irritants include burning,
stinging and soreness at the site and physical signs of the reaction include erythema, vesiculation and oozing.
Strong irritants produce blistering, erosions and ulcers. Acute reactions will have sharply demarcated borders
and will generally be asymmetrical. Cumulative irritant contact dermatitis is a consequence of multiple
subthreshold skin insults without sufficient time in between for complete restoration of skin barrier function. It
may be due to a variety of stimuli or frequent repetition of one factor, especially if occupational. Clinical
symptoms will develop only after cumulative damage exceeds the threshold, and the lesions may be less well
demarcated. Hand dermatitis occurs principally on the fingers, web spaces and dorsa of the hand. Palms are
spared and dryness, erythema and scaling are early features. It often begins on the fourth finger, beneath a
ring.9 Long-term glove occlusion and the accumulation of barrier damage from hand washing, even when mild
hand cleansers are employed, may lead to cumulative skin irritation.30
Allergic Contact Dermatitis: This is a pruritic eczematous reaction which in its mild form is similar to exposure
to an irritant. A typical allergic reaction consists of grouped or linear tense vesicles and blisters, and in severe
involvement, marked edema, particularly on the face and in periorbital and genital areas. The acute form can
also have a diffuse patchy distribution depending on the allergen (for example, body washes and shampoos
that get rinsed over the body) and/or the development of disseminated auto-sensitization (acute, generalized
dermatitis arising in response to a prior localized inflammatory reaction). The suspected diagnosis is based on
clinical symptoms, a plausible contact to allergens and a suitable history of dermatitis. Differential diagnoses
should be considered only after careful exclusion of any causal contact sensitization. Careful diagnosis by
patch testing is of great importance. Modifications of the standardized test procedure are the strip patch test
and the repeated open application test.31
Common Contact Allergens
A list of contact allergens is presented in Table 1. The most common contact allergens include plants of the
Rhus genus, nickel, rubber, ethylenediamine (a stabilizer in many topical preparations) and
paraphenylenediamine (an ingredient in black hair dye and industrial chemicals).32 Nearly any chemical can
produce contact dermatitis. Small molecules are most likely to be sensitizers since they penetrate the
epidermis more readily. The possibility of cross-sensitization with other chemicals is an important
consideration. The most notable are listed in Table 2. Cross-sensitization may prohibit use of critically
important systemically administered drugs.9
Table 1: Common Causes of Contact Dermatitis

Type of Dermatitis Substance Source
Allergic contact Aloe vera Topical medications and cosmetics

dermatitis
Bacitracin Topical antibiotic creams, eye and ear

preparations
Balsam of Peru Cough syrups, flavourings
Benzocaine Topical antibiotic creams, eye and ear

preparations
Cetylstearyl alcohols Topical medications, cosmetics, paste

bandages
Chromium salts Potassium dichromate electroplating,

cement, leather tanning agents,
detergents, dyes
Cobalt chloride Cements, metal plating, pigments in

paints
Ethylenediamine Dyes, fungicides, medications
Formaldehyde Germicides, plastics, clothing, glue,

adhesives
Fragrances Topical medications, baby products,

cosmetics, household products
Lanolin Topical medications, bath oils and

cosmetics
Latex Rubber products, e.g., gloves,

catheters, balloons, plants, medical
devices, tires, conveyor belts
Methylisothiazolinone Baby wipes
Neomycin Topical antibiotic creams, eye and ear

preparations
Nickel Metal alloys, hairpins, jewelry, zippers,

hair dyes
Paraphenylenediamine Hair and clothing dyes, chemical

photographic use
Potassium dichromate Cement, leather, household cleansers,

bleaches
Type of Dermatitis Substance Source
Quaternium 15 Preservative in topical medications

and cosmetics
Rhus genus Poison ivy, poison oak, mangos
Rosins (gum and wood) Topical medications
Rubber accelerators Rubber products (ostomy products,

(mercaptos/carbamates/thiurams) bandages, latex products, toys,
condoms, diaphragms, goggles,
pacifiers)
Topical antihistamines Topical medications
Irritant contact Acids Solvents

dermatitis
Alkalis Surfactants
Enzymes Wet cement
Oxidants Hydrogen peroxide, household bleach
33,34
Table 2: Cross-sensitizers with Common Contact Allergens
Sensitizers Cross-sensitizers
Ethylenediamine Aminophylline, ethylenediamine antihistamines
Latex Bananas, kiwi, pineapple, chestnuts, avocados, apricots, cherries,

grapes, passion fruit, potatoes, peaches, tomatoes (occasionally
other fruits and nuts). Alert healthcare practitioners prior to
procedures.
Local anesthetics (ester type, e.g., Para-amino-containing compounds (widely used in topicals):
benzocaine) parabens, some oral hypoglycemics, sulfonamides, thiazide
diuretics
Neomycin Aminoglycosides (gentamicin, tobramcyin), framycetin
Rhus Lacquers from China and Japan, mangos, cashews and ginkgo
Allergens of Note
Plants
Toxicodendron plants, also known as Rhus and poison ivy account for the largest number of cases of
allergic contact dermatitis. The typical warning to avoid contact is “Leaflets three, let it be.” The leaves,
stems, seeds, flowers, berries and roots of plants contain milky sap that turns into a black varnish-like
substance on exposure to air. Once the solvent evaporates, the allergen (urushiol) remains and is antigenic
indefinitely, even if the plant has died.33 Sensitization is immediate with the formation of a complex protein
in the skin that is not removed through washing. Sensitization and dermatitis occur after 7–10 days, and re-
exposure produces a reaction within 8 hours to 2 days. Streaks of erythema or papules, vesicles and bullae
in linear arrangement are a characteristic clinical presentation and accompany itching and edema as key
features.12 Urushiol is nonvolatile. Smoke may carry the poison in dispersed form.33 See Table 1 and Table
2.
Latex
Natural rubber latex, sourced in southeast Asia, is a leading cause of immunologic contact urticaria, and
can cause IgE-mediated skin-related findings as well as acute respiratory symptoms and even anaphylaxis.
Delayed contact allergy may exist more commonly than previously noted, particularly in atopic individuals.
Immediate latex allergy (irritant contact dermatitis) is not the same as the more common, less severe T cell-
mediated delayed hypersensitivity reaction seen clinically as allergic contact dermatitis.34
Added ingredients to rubber products may cause allergic contact dermatitis: accelerators in the rubber
product make it more functional, antioxidants and antiozonants (parapheylenediamine) delay degradation,
and other chemicals increase softness and pliability. Allergic contact dermatitis is due to carbamates and
thiurams in rubber gloves, mercaptos and parapheylenediamine in shoes, industrial materials and tires, and
thioureas in neoprene (used in medical and sporting goods).34 See Table 1 and Table 2.
Metals
Metals are the most common contact allergens; nickel is the most common cause of metal allergy and in
most series ranks as the most commonly positive of all screening allergens.35 Nickel allergy can result in
both cutaneous and systemic manifestations.36 Reactions to gold, chrome and cobalt are also frequently
seen. Cross-sensitization to other metals can occur, e.g., nickel and palladium. Cobalt, nickel and chromium
may induce co-reactions and other substances may contain them (cobalt in cement). Usually, the metals
must be in solution for allergic contact, but can be liberated by sweat. Nickel, palladium and titanium are the
most common metal allergens in contact dermatitis due to eyeglass frames.37 Metals can also be ingested
(dietary nickel) or due to sources such as orthopedic implants.35 Irritant contact dermatitis to metals is
common in workers exposed to metal salts, dust or fumes.35
Antibiotics
Topical antibiotics used long-term on skin with impaired protective barrier leads to increased risk of
hypersensitivity. Groups at a high risk of contact sensitivity include: patients with chronic venous
insufficiency, chronic ulcers or chronic otitis externa, or individuals with occupational exposure to
antibiotics (e.g., human medicine and veterinary medicine practitioners, pharmaceutical industry workers,
cattle breeders). When long-term therapy with topical antibiotics in these patients fails to result in
improvement, allergic reactions to topical antibiotics should be considered. Cross-sensitivity, which is
frequently associated with topical aminoglycoside antibiotics, poses a significant problem.38
Bacitracin is an antibiotic used in several types of consumer products, including cosmetics and ophthalmic
and skin ointments. Bacitracin was the ninth most common contact allergen detected in 2003, causing
more than 9% of positive reactions among 5812 patients with suspected contact dermatitis.39 Because
bacitracin is used on wounds and is often inappropriately applied to fungal infections, the diagnosis of
contact dermatitis can often be elusive. Reactions may be attributed to a slow-healing wound or worsening
infection that is treated, ironically, with more topical antibiotic agents. Due to the significant prevalence of
bacitracin allergy, the American Contact Dermatitis Society warns it should not be used routinely.39 Clinical
affect, scientific evidence, and need for medical cost containment all advocate the discontinuation of
routine usage of bacitracin in clean wounds. Table 3 reports changes in common allergic responses, which
reflects routine usage.
Antihistamines
Topical antihistamines have been reported to cause contact dermatitis. Doxepin cream was the most
commonly implicated topical preparation. A causal relationship is often difficult to recognize because the
reaction may be similar to the disease being treated with the antihistamine preparation. Cross-reactivity
within the same class of medication is likely but not certain.40
Preservatives
Many preservatives can cause allergic contact dermatitis (e.g., parabens, formaldehyde).
Methylisothiazolinone is a preservative commonly found in baby wipes. Incidence of allergy to this chemical
is rising with increasing use and some jurisdictions are calling for a ban on its use. It has been suggested
that it is common enough to be included in the standardized series of allergens used in patch testing.41 In
Canada, concentration of methylisothiazolinone used alone is limited to 100 ppm, however this is 25 times
the limit allowed when it is used in combination with methylchloroisothiazolinone (see Diaper Dermatitis for
more information).42
Emulsifiers
Sorbitan sesquioleate and/or sorbitan monooleate are emulsifiers in many topical corticosteroid products.
One study and its follow up found incidence rates for allergic contact dermatitis due to these chemicals of
8.9% and 4.1% respectively. The authors suggest that given the presence of sorbitans in many topical
corticosteroid formulations, allergy to these chemicals should be considered when patients do not improve
as expected with topical corticosteroid therapy.43
39
Table 3: Most Common Patch-test Responses in Patients with Suspected Contact Dermatitis
Substance Percentage of Patients Exhibiting Reaction
Nickel sulfate 16.2%
Balsam of Peru 12.3%
Neomycin 11.5%
Fragrance mix 10.9%
Thimerosal 10.8%
Sodium gold thiosulfate 10.5%
Formaldehyde 9.2%
Quaternium 15 9.2%
Bacitracin 9.2%
Cobalt chloride 7.6%
Consort Contact Dermatitis: Skin-to-skin contact can result in transfer of potential contact allergens
from one sex partner to the other and may result from lubricants, hygiene products, seminal fluids, and
rubber in diaphragms and condoms.14
Impaired Cell-mediated Immunity: Risk is reduced with impairment of cell-mediated immunity, such as
AIDS, lymphomas or atopic dermatitis. Atopic patients are more likely to develop pustular reactions
when exposed to nickel.14
Diet: It has been suggested that diet may play a role in allergic contact dermatitis. Approximately 30–
50% of patients with latex allergy have hypersensitivity to certain fruits. Presence in food of nickel (e.g.,
from water, cooking utensils) or balsam of Peru (e.g., wine, candy chocolate, curry) can aggravate
allergic contact dermatitis; eliminating these items from the diet may alleviate symptoms.44
Ethnicity: The incidence of contact dermatitis in Caucasians is greater than blacks due to their greater
skin reactivity; however, blacks experience a higher incidence of paraphenylenediamine allergy.
Caucasians have a looser packing of skin layers and fewer intercellular lipids, making their skin more
permeable to irritants and allergens.45
Gender: Although women develop contact dermatitis more often than men, it is primarily because
women are more frequently exposed to irritants, allergens and wet work, and not because of differences
in skin reactivity.45
Body Site: Eyelid contact dermatitis may be due to mascara, cosmetic preservatives, nail polish, hair
cosmetics, eyeliner, ophthalmic medications, adhesives in false eyelashes, eyelash curlers, paper
products, plants, airborne materials and dyes. The chest and abdomen are sites for allergy to metals and
elastic objects, and genital areas are susceptible to dermatitis from hygiene products, contraceptives,
condoms and seminal fluid. Nails exhibit contact dermatitis from acrylate applications, hardeners,
enamels, hydroquinone in bleaching creams, weed killers, insecticides and physical trauma.46
Climate: Seasonal variation occurs with increased prevalence during winter months and exposure to
cold, dry air.32
Occupation: Individuals at risk of contact dermatitis are often those who are exposed to these
substances occupationally or as part of their daily routine. Exposure to organic solvents together with
detergents may increase the risk of acquiring occupational contact dermatitis.47 Rhus dermatitis is seen
less often in dark-skinned individuals, more commonly in younger persons, and is a hazard for outdoor
workers and enthusiasts.
Latex allergy (from rubber gloves and other sources) is common in healthcare practitioners. The medical
community is also at risk of contact dermatitis due to occupational substances, including mucolytics,
dressings, adhesive removers, gowns, scrub solutions, formaldehyde and glutaraldehyde, mercury
(dentists) as well as active drugs such as anesthetics, essential oils, antibiotics and inactive ingredients
including aluminum, petrolatum, oils (olive, castor and sesame) and lanolin.48
Other occupations that can increase the risk of contact dermatitis include photography, textile work,
printing industry, agricultural work, office work (carbon sources), bakery work and hairdressing.49 Hand
dermatitis as a subtype of contact dermatitis is often seen in healthcare practitioners, hairdressers and
dishwashers, especially in those who have atopic dermatitis. Susceptibility is greater among younger
people. Bakers and chefs may experience food contact dermatitis due to sorbic acid preservatives,
antioxidants, flavour ingredients (peppermint, cinnamon, anise, coriander, garlic, sesame, cashew) and
food additives, such as dyes, and benzoyl peroxide.50 Plant allergy may include extracts used in
medications such as balsam of Peru, rosin and benzoin.51
Ultraviolet Light: Photocontact dermatitis requires exposure to UV light and may occur due to irritant or
allergic causes. Irritant reactions (phototoxic) can occur in anyone due to substances like psoralens,
whereas photoallergic contact dermatitis occurs only after an individual with sensitivities is exposed to
an allergen. Fragrances and sunscreen chemicals are causes of photocontact dermatitis.52
Stasis Dermatitis
Stasis dermatitis, which occurs due to venous insufficiency, is seen on the lower leg. Acute changes consist of
inflammation, edema, pigmentation and ulceration. The eruption may be erythematous and oozing, with
marked inflammation. Chronic stasis results in scaling, discoloration and lichenification and is accompanied by
edema due to venous disease. This may result in fibrosis, producing hardening and induration of soft tissue.
Pigmentation is invariably present in the early stages due to dermal extravasation of red blood cells following
small venule rupture. Superficial ulceration may result from acute inflammation and may heal or progress to
deeper ulcers. Superficial venous varicosities may also be present.9
Differential Diagnosis of Dermatitis
Table 4 outlines other conditions that should be considered in the differential diagnosis of eczematous dermatitis.
Table 4: Differential Diagnosis of Eczematous Dermatitis

Infections and infestations Papulosquamous conditions
Scabies (see Parasitic Skin Infections: Psoriasis (see Psoriasis)

Lice and Scabies)
Candidiasis (see Fungal Skin Seborrheic dermatitis (see Dandruff and

Infections) Seborrheic Dermatitis)
Herpes (see Viral Skin Rashes) Neoplasms
Tinea (see Fungal Skin Infections) Cutaneous T cell lymphoma
Staphylococcus aureus infections Photosensitivity (see Prevention and

(impetigo) (see Bacterial Skin Treatment of Sun-induced Skin Damage)
Infections: Impetigo, Furuncles and
Carbuncles)
Metabolic diseases Immunodeficiencies
Fatty acid deficiencies
Differentiating Features of Atopic, Contact and Stasis Dermatitis
Table 5 outlines the differentiating features of common dermatitis subtypes.
Table 5: Differentiating Features of Subtypes of Dermatitis

Goals of
Condition Duration/Location Description Trigger Factors Therapy
Atopic 2 months; chest, Cycles of itching and Extreme heat or Decrease

dermatitis face, neck, diaper scratching. Red, cold, rapid trigger factors
area raised blisters with temperature and pruritus
oozing, dry skin changes, sweating, Suppress
irritant or occlusive inflammation
clothing (wool or
2 y; scalp, neck, Lubricate skin
nylon), soaps and
extremities
detergents, Alleviate anxiety
greases,
4–10 y; scattered— Less acute and environmental
neck, wrist, elbow, oozing; dry papules, allergens, anxiety,
knee thickening, periorbital infections
edema and erythema
12–20 y; flexor Dry, thickened,

areas, hands hyperpigmented
plaques
Contact Irritant/allergic: In Unusual patterns Irritant: Time and Decrease

dermatitis contact area resembling concentration of contact
(irritant and Allergic: May contacting substance irritant exposure to
allergic) generalize Acute: Red, blisters, Allergic: irritants and
oozing, may erode Sensitization to allergens
Chronic: Dry, thick, allergen If dry, wet it

fissured If wet, dry it
Dry skin Lower legs (shins), Mild to moderate: Dry Increasing age, Replace water
dorsa of hands, skin with fine scale; decreased in the skin and
forearms diffuse or round humidity, increased the environment
patches indoor heat, cold,
Severe: Cracks and dry, winter air,
fissures in diamond contact with soaps
pattern with redness and irritants,
hypothyroidism
Goals of
Condition Duration/Location Description Trigger Factors Therapy
Hand Irritant: Sides of Redness, dryness, Repeated contact Decrease

dermatitis the fingers, less chapping; small with primary contact
often throughout vesicles; excess irritants, soap and exposure
palms sweating water, solvents and
Allergic: Back of detergents
the hands Family history of
atopic dermatitis
or psoriasis
Stasis Lower leg, proximal Acute: Inflammation, Venous Decrease

dermatitis to medial edema, pigmentation insufficiency, and triggers, bed
Malleolus and ulceration edema, upright rest and
Chronic: Scaling, posture, hot, humid elevation,
discoloration, environment, compression of
lichenification sensitizers leg
Drug-induced Dermatitis
Eczematous eruptions can also occur with many drugs given either topically or systemically. Cross-sensitivity may
occur with structurally related drugs administered by either route. Common sensitizers include antibiotics,
phenothiazines and the ester group of anesthetics. As a rule, the eruption starts shortly after administration of the
drug, if previous sensitization has occurred. Patch testing with the responsible drug will give positive results. Table
6 lists drugs that commonly evoke eczematous reactions.53
53
Table 6: Drugs that Commonly Cause Eczematous Eruptions
Antibiotics chloramphenicol
clioquinol
gentamicin
neomycin
penicillin
streptomycin
sulfonamides
Antihistamines promethazine
Antipsychotics phenothiazines, e.g., chlorpromazine, fluphenazine, perphenazine,

prochlorperazine, trifluoperazine
Beta-blockers metoprolol
propranolol
timolol
Calcium channel blockers54,55 amlodipine

diltiazem
felodipine
nifedipine
verapamil
Diuretics thiazide diuretics
Sulfonylureas chlorpropamide
tolbutamide
Miscellaneous aminophylline
carbamazepine
chloral hydrate
cyanocobalamin
fluorouracil
idoxuridine
minoxidil
nitroglycerin
nystatin
procainamide
quinine
quinidine
Severe or Complicated Dermatitis
Atopic dermatitis that is acute and vesicular, or if moderate to severe (defined as: generalized to more than 30% of
the body surface area (BSA), continues to involve larger body areas, remains unresponsive, becomes secondarily
infected or interferes with activities of daily life or sleep patterns) requires further assessment and treatment by an
appropriate healthcare practitioner. Parameters for assessing severity of atopic dermatitis include: Eczema Area
Severity Index (EASI)56 score (a tool used to measure the severity and extent of atopic dermatitis in order to
assess clinical response to treatment), quality of life measurement tools (e.g., Dermatology Life Quality Index),56
sleep disturbances, itch (diary), redness, scale, dryness and amount of emollient used. If there is uncertainty about
the diagnosis, of if there is suspicion of wide spread herpes simplex, an appropriate healthcare practitioner should
be consulted.57
Contact or stasis dermatitis that spreads to distant sites or becomes generalized to more than 30% of BSA, is
acute and nonresponsive within a few days, includes edema that persists or increases within a few days, is chronic
and nonresponsive within 7–10 days or interferes with quality of life is considered severe or complicated and
requires further assessment and treatment by an appropriate healthcare practitioner. To identify the cause of
allergic contact dermatitis, practitioners generally use the patch test during which standard concentrations of
known substances are applied to the skin and the reactions monitored. Provocative and open use tests may be
used after patch testing to distinguish an allergic from an irritant response. Other tests include prick tests and
intradermal tests.58
Atopic and Contact Dermatitis
Avoidance of irritants and aggravating factors is key. A thorough history is essential to identify the cause,
especially any previous treatments that may have exacerbated symptoms or cross-reacted with the irritant or
allergen.
Environmental factors that can modulate the effect of irritants include temperature, humidity and texture of
fabrics. Intense sun exposure should be avoided. Temperature in home and work environments should be
temperate with moderate humidity to minimize sweating and reduce problems related to heat and perspiration. Air
conditioning in the summer and a cool air humidifier in the winter may be helpful. If a humidifier is not available, a
bowl of water in the room will enhance ambient humidity.
New clothing should be laundered prior to wearing to remove formaldehyde and other chemicals.20 Occlusive
clothing should be avoided and loose-fitting cotton or cotton blend garments substituted for nylon, and corduroy
for wool. Many blended fabrics are well tolerated. Texture or roughness, rather than fabric type (natural vs.
synthetic) determine tolerability and skin irritancy.20,59,60 Liquid fabric softeners or dryer sheets should be avoided
because plumping up fibres and making them erect increases irritancy. Bleach in the rinse also irritates and should
be avoided. A dilute vinegar rinse can be substituted. Use of liquid rather than powder detergent can result in more
complete rinsing; adding a second rinse cycle may facilitate removal of residual powder detergent.
Swimming may be a better tolerated sport than those involving intense perspiration or physical contact and may
improve dermatitis. Bathing may also remove allergens from the skin surface and reduce colonization by S. aureus.
Despite a drying or irritating effect, swimming in chlorinated pools results in clinical improvement in some atopic
patients. Rather than simply rinsing off after swimming, gentle cleansers should be used to effectively remove the
chlorine or bromine, and then moisturizer should be applied.20
Wearing cotton gloves or mittens prevents scratching and secondary infections and allows healing of affected
hands. They can be used as a barrier against irritants such as newsprint when reading the paper, and can also
allow children to play or perform normal activities, with good acceptance. Keeping fingernails clean and short is
essential.
A diet that excludes specific foods is not recommended for patients with atopic dermatitis without confirmed food
allergy.57 Intervention is indicated in only about 10–15% of atopic children, when the disease is of sufficient
severity and there is a strong suspicion that certain food(s) aggravate the condition. Restrictions in diet should not
have a greater effect on quality of life than the disease. Risks of dietary restriction must be kept in mind: such diets
may lead to malnutrition and deficiencies, carry the risk of anaphylactic reactions upon rechallenge to a restricted
food, and challenge the psychological and social well-being of the child.7 If foods aggravate atopic dermatitis, they
represent only a fraction of the expression of the disease. Exclusion of foods in pregnancy or breastfeeding to
prevent development of atopic dermatitis is not recommended.57 The benefit of breastfeeding is recognized;
patients should be advised that exclusive breastfeeding for the first 3 months or more may help prevent the
development of atopic dermatitis where there is a family history of atopy.20 Hydrolyzed formulas should not be
offered to infants in preference to breast milk for prevention of atopic dermatitis. The introduction of any specific
solid food (soft, mashed consistency to prevent choking) should not be delayed beyond 6 months of age. Later
introduction of peanut, fish or egg does not prevent, and may even increase, the risk of developing food allergy.
Skin or specific IgE blood testing before a first ingestion is discouraged due to the high false-positive rate. Regular
ingestion (several times weekly) of newly introduced foods is important to maintain tolerance.61 Maternal use of
probiotics during pregnancy and maternal and/or infant use during breastfeeding may be helpful in reducing the
development of atopic dermatitis in the child.62,63,64,65 Strain and dose of probiotic is not consistent across
studies. There is insufficient evidence to recommend the use of probiotics for treatment of established
eczema.66,67
Wet dressing solutions used in atopic and contact dermatitis may include ordinary tap water or saline, in addition
to pharmacologic solutions containing astringent and/or antiseptic compounds. The action of a wet dressing is
primarily physical, and thus water or physiologic saline are the solutions of choice as they are convenient,
inexpensive and pose no problems of sensitivity or damage to healing wounds. Note that the technique used in
applying wet dressings determines the effect on the skin: used as compresses, they are drying, whereas used as
soaks, they are hydrating. The rule of thumb for application of wet dressings is “If it is wet, dry it (compress); if it is
dry, wet it (soak).”
Wet dressings as compresses cool and dry the skin through evaporation. They reduce inflammatory blood flow,
cleanse the skin of exudates, crusts and debris and help maintain drainage of infected areas through
vasoconstriction. They are indicated in acute eczematous conditions with oozing and crusting, which can be seen
in atopic, contact or stasis dermatitis. The solution should be tepid or room temperature, although cold solution is
effective in relieving itch in skin that is otherwise not symptomatic. A nonirritating gauze or thin cloth is soaked
with solution, then wrung gently so it remains wet but not dripping. The compress is applied to the skin, removed,
remoistened and reapplied every few minutes for 20–30 minute periods, 4–6 times daily (“a minute on, a minute
off”). After removal, a lotion may be applied to the skin, but avoid occlusion with an ointment. Powders are not
applied to any exudative lesion as they crust, causing bleeding on removal and increased risk of infection.
Wet dressings as soaks soften hardened crusts in scaling conditions usually apparent in chronic atopic, contact or
stasis dermatitis, and can hydrate the skin. To apply a soak, saturate the cloth and apply to the area for 15–20
minutes without removal. This procedure occludes and breaks down underlying tissue. Soaks are never used for
acute, exudating dermatitis as they may macerate the skin, further damaging barrier function. Chronic contact
dermatitis that is dry or fissured should be soaked for 5 minutes rather than compressed before application of an
occlusive emollient.
Wet-wrap therapy with or without a topical corticosteroid can be recommended for patients with moderate to
severe atopic dermatitis and/or recalcitrant disease to decrease disease severity and water loss during flares. It
may be performed on an ambulatory or inpatient basis. Most use a technique of a topical agent covered by a
wetted first layer of tubular bandages, gauze, or a cotton suit, followed by a dry second/outside layer. For more
generalized disease, 2 layers of nonirritating clothing can be similarly prepared. Rationale includes occluding the
topical agent for increased penetration, decreasing water loss, and providing a physical barrier against scratching.
The wrap can be worn for several hours up to 24 hours at a time, depending on patient tolerance. Most suggest
several days of use, although a few studies continued for up to 2 weeks. Use of topical corticosteroids under the
wet wraps seems to be more efficacious than using only moisturizers with the wraps. Care should be taken if mid-
to higher-potency corticosteroids are applied under the wraps, as absorption is increased and may cause
hypothalamic-pituitary-adrenal axis suppression, especially if used widely on the skin. Temporary decreases in
early morning serum cortisol levels have been reported, although short courses of use have not been associated
with prolonged adrenal suppression. The potential for increased risk of infection has been raised with the use of
mid- to higher-potency topical corticosteroids in wet-wrap therapy, although the data are sparse and conflicting
regarding its actual occurrence.68
In the case of atopic dermatitis, control of trigger factors and anxiety is a major strategy. Control of exposure to
environmental inhaled allergens is important. Direct contact with allergens and irritants should be reduced. Limit
soap cleansing to axillae and groin, using mild soaps, creams or soapless cleansers (Table 8). Restrict showers to
once weekly, if possible. Use bathing to rehydrate the skin and follow with liberal use of emollients to prevent
evaporation. Water temperature should be warm, not hot.
If contact dermatitis is acute, some principles should be kept in mind. The affected area should be washed
immediately and thoroughly. If wet or oozing, compresses with saline or tap water can be applied (1 minute on, 1
minute off for 20–30 minutes) 4–6 times daily. Protect the damaged skin against secondary infection until the
acute stage subsides. Do not allow debris due to oozing, scaling and crusting to accumulate (see
Nonpharmacologic Therapy, Wet Dressings).
Patients with contact dermatitis should avoid touching the following with bare hands: fruit juices, raw meat, fish
and vegetables, especially raw onions and garlic; detergents, turpentine and kerosenes; hair tonics and shampoos.
Remove rings when washing hands, as trapped soap may produce flares. Use an unscented soap or hand cleanser
free of colour, antiseptics, deodorants, vitamins and tar. Wash hands with lukewarm water and use soap sparingly.
Rinse hands thoroughly and dry with clean towel, especially between fingers. Wash as infrequently as possible, no
more than 2–3 times daily. Hands can be protected with plastic or vinyl gloves worn with cotton liners, but rubber
gloves should be avoided. In hand dermatitis, avoid activity that involves friction, pressure, squeezing or twisting. A
low nickel diet for vesicular hand dermatitis can be helpful in select nickel-sensitive cases.69 Avoid adhesive
bandages. Chronic hand dermatitis often becomes secondarily infected, especially if fissured, and should be
managed appropriately. Despite lack of evidence, small, noninfected fissures can be closed with cyanoacrylate
glue (e.g., Superglue). Occlusive dressings such as kitchen plastic wrap (overnight) may expedite healing.
Stasis Dermatitis
Local treatment of stasis dermatitis varies with the state of inflammation. Apply only those topical medications
considered essential as patients with stasis dermatitis are readily sensitized; 80% of patients with chronic stasis
dermatitis are at risk of contact dermatitis. Ointment bases are the most common inciting agents.70
The reduction of edema is important and achieved through bed rest and elevation of the extremity. After edema
subsides, compressive support in the form of an elastic bandage should be applied. After the dermatitis is healed,
advise the life-long use of elastic compression stockings.9
Cough, Cold and Allergy Products; Skin Care Products: Dermatitis and Dry Skin, First Aid.
For further information on the pharmacologic treatment of atopic dermatitis, consult Compendium of Therapeutic
Choices: Atopic Dermatitis.
Bath Products
In most dermatitis conditions, dryness at some stage initiates or exacerbates the symptoms. The primary means
of correcting dryness is to add water to the skin and then to apply a hydrophobic substance to keep it there. The
benefits of hydration and moisturizers to help restore and maintain normal barrier function cannot be
overemphasized. Since wet skin is more permeable to water, it is essential that the skin be covered within the first
few minutes to prevent evaporation. Appropriate use of hydration together with occlusive bases or moisturizers will
help re-establish and maintain the skin's barrier function. Bathing can have differing effects on the skin depending
on the manner in which it is carried out. Bathing with water can hydrate the skin and remove scale, crust, irritants,
and allergens, which can be helpful for patients with atopic dermatitis. However, if the water is left to evaporate
from the skin, greater transepidermal water loss occurs.71 Bathing is suggested for patients with atopic dermatitis
as part of treatment and maintenance; however, there is no standard for the frequency or duration of bathing
appropriate for atopic dermatitis. However, it is generally recommended that up to once-daily bathing be performed
to remove serous crust; the duration should be limited to short periods of time (e.g., 5–10 minutes) with use of
warm water. Moisturizers should be applied soon after bathing to improve skin hydration. Hydration of the face or
neck can be achieved by applying a wet washcloth or towel to the involved area. Isolated areas such as hands and
feet can be treated with soaks in basins. For the treatment of patients with atopic dermatitis, there is insufficient
evidence for clear recommendations on the addition of oils, emollients and most other additives to bath water, or
the use of acidic spring water.72
Despite lack of evidence it is generally thought that bath oils applied during or after bathing may help to reduce the
rate of water loss through the epidermis; however, they are less effective than lotions and creams applied directly
to wet skin since they are diluted with water and are in contact with the skin for a short time period, and most of
the deposited oil is wiped off when towel drying. If added at the beginning of the bath, they may prevent rather than
enhance hydration and thus should be added near the end of the bath to trap water in the skin. Bath oils give a
false sense of lubrication and can make the bathtub slippery. Most bath oils combine mineral or vegetable oils with
surfactants that disperse oil through the bath. Concentrations of surfactants (e.g., sodium lauryl sulfate) above 4%
reduce the affinity of oil for the skin. Avoid products with fragrance and lanolin. Oil used as a single ingredient will
float on top of the water. Bath oil capsules enclose small amounts of oil in soft, flexible gelatin capsules that
dissolve in hot water but may necessitate a higher water temperature than desirable and often contain a higher
percentage of fragrance. Olive oil is an inexpensive natural product that may be applied directly to rehydrated skin
after bathing.
Avoid bath salts. They are highly fragranced and soften water by raising the alkalinity. This may cause itching or
redness on sensitive skin. Avoid detergent bubble baths if skin is dry or itchy.
Colloidal oatmeal preparations contain starch and protein and are effective antipruritics. Addition of oatmeal
products may be soothing but does not promote increased water absorption. For dry skin, they are not as effective
as oils in trapping water to maintain hydration unless the oilated versions are used. Bathing in colloidal oatmeal
baths is useful when large body areas are involved.69
Soaps are made from animal or vegetable fat and alkali and consist of surfactants that interact with stratum
corneum proteins and lipids in a manner that causes damage, dry skin, and irritation. Most soaps are alkaline in
pH, whereas the skin’s normal pH is 4–5.5. Fatty acid plus sodium or potassium hydroxide produce a water-soluble
soap. Toilet soaps are usually made from palmitic, stearic or oleic acids. Hard sodium soaps are suitable for bars,
flakes and powders while more soluble potassium soaps are used for liquid preparations. Softer and more water-
soluble, transparent soaps (or glycerin soaps) do not last long or lather well. They claim to be less drying or
irritating than alkaline opaque soaps. However, objective clinical evaluations are lacking.
Soapless cleansers are surfactants and synthetic detergents often recommended for better tolerance, although
this is based on only a few clinical studies. They lack lipid and are available in lotion and gel forms. Soapless
lotions can be applied liberally and have a foaming action. Removed gently, they leave a thin film on the skin to aid
in water retention. No good evidence demonstrates that addition of neutral fats or cold cream to the soapless
cleanser counteracts the drying effect. It is improbable that a simple cleansing agent can achieve the 2 opposing
tasks (cleansing of the skin and deposition of fat on the skin), especially since the soap is rinsed off. Limited use
of soapless cleansers (that are neutral to low pH, hypoallergenic and fragrance free) is recommended.
Excessive washing may remove lipids and water that normally keep the stratum corneum soft and pliable. Choice
of soap depends on the type of dermatitis. Avoid soap in acute atopic or contact dermatitis. For chronic dermatitis
and for dry skin, a mild, nonalkaline soap, an aqueous cream or a soap-free cleanser can be used alternately (Table
8). Soap is applied only to intact skin, without rubbing or massaging. Sufficient water should be used to rinse away
all traces of soap.
Moisturizers
Breakdown of the skin barrier, the first event in the development of atopic dermatitis, results in xerosis (dry skin),
one of the cardinal clinical features. This provides a rationale for the use of a complete moisturizing therapy
regimen to combat xerosis and transepidermal water loss (TEWL) in atopic dermatitis and related skin barrier
breakdown conditions such as irritant contact dermatitis.73 The main purpose of moisturizer therapy is to restore
the epidermal barrier, which is composed of corneocytes, extracellular proteins, and a lipid-rich matrix (ceramides,
fatty acids, and cholesterol). Barrier damage is directly correlated to the severity of dermatitis. Use of moisturizers
leads to the integrity of the epidermal barrier and a consequent reduction of both TEWL and penetration of irritant
substances.
Patients with atopic dermatitis require ongoing moisturizer therapy. Clinical trials have shown that they lessen
symptoms and signs of atopic dermatitis, including pruritus, erythema, fissuring, and lichenification.72 Moisturizers
can themselves result in some reduction in inflammation and atopic dermatitis severity. There is strong evidence
that their use can also reduce the need for pharmacologic intervention. Moisturizers are first-line therapy for mild
disease and an important part of the treatment regimen for moderate and severe disease. They also play a key role
in maintenance treatment and prevention of flares.72
Skin protection creams or “barrier” creams (usually silicone-based) may be used in the occupational setting to help
prevent irritant contact dermatitis. The protective efficacy depends on the amount of product applied per unit skin
surface area. The actual amounts applied and the resulting dose per unit area have been reported to be lower than
recommended. Some products may show no protective efficacy when used at doses close to those practically
applied at workplaces.74 In 1 study, 2 of 6 protective creams failed to prevent solvent-induced cumulative skin
irritation, which emphasizes the lack of comparative efficacy among barrier creams.75 Antioxidant creams have
been shown to effectively protect the skin from chemical-induced irritation.76 Unfortunately low adherence to skin
protective measures that combine creams and other approaches has been reported after 1 year.77
Moisturizers are generally classified by their mechanism of action as emollients, occlusives, or humectants. Newer
agents containing ceramides may be classed as barrier repair agents.
Emollients
Emollients are semisolid bases designed to control dryness by slowing evaporation and lubricating the stratum
corneum. They may contain glycol, glyceryl stearate, and soy sterols which lubricate and soften the skin. These
products cannot keep skin soft and flexible without the required concentration of water in the skin and function
only to trap existing moisture. Very little water from emollients is absorbed by the skin; most water in the
emollients evaporates when the product is applied and therefore they should be applied while the skin is still damp
from bathing. Emollients include lotions, creams and ointments. Most are oil-in-water or water-in-oil emulsions.
The higher the oil content, the greater the occlusion and the less drying through evaporation. Ointments are
therefore the most occlusive and have the fewest additives, though in a hot, humid environment their use may lead
to trapping of sweat with subsequent irritation of the skin. Users may not tolerate oil or water-in-oil products
because the greasy texture increases discomfort. Greasy applications are unsuitable for acute oozing dermatitis.
In contrast, evaporating water from oil-in-water creams or more liquid oil-in-water lotions produces a cooling effect
which alleviates pruritus. A smaller amount of oil content is left as a residual film to protect hydration. Lotions
contain more water than creams and may be drying due to the effects of evaporation. Obtain products in the
largest size available because they usually need to be applied several times a day on a long-term basis.
Scrutinize the emollient product for other ingredients, as some preservatives, stabilizers, emulsifiers and
fragrances may aggravate atopic, allergic or stasis dermatitis (e.g., lanolin, parabens, cresols, sodium lauryl sulfate,
cetylstearyl alcohols and fragrance). Choose an emollient for its drying or lubricating properties as suitable for the
stage of dermatitis. For an acute, wet dermatitis that has been compressed, apply a lotion after oozing stops, to
facilitate dryness. In less acute, drier dermatitis, an oil-in-water emulsion base is appropriate. In chronic, very dry or
scaly dermatitis, a water-in-oil emulsion gives maximum lubrication. Hairy areas may require gels or lotions.
Occlusives
Occlusive agents (petrolatum, dimethicone, mineral oil) form a layer on the skin that retards evaporation of water.
Petrolatum provides an occlusive effect but is cosmetically unacceptable as it feels greasy and does not wash off
easily. It is sometimes used as a sealer after hydrating the skin; however, it is effective only when used in
conjunction with hydration. Due to its highly occlusive properties, it can cause maceration and overgrowth of
bacteria or yeast if used on acutely inflamed and oozing lesions. Petrolatum is discussed further as an alternative
for diaper dermatitis (see Diaper Dermatitis).
Humectants/Hydrating Agents
Humectants are ingredients with hygroscopic properties to attract and hold water in the skin. Emollients to which
humectants have been added may be called hydrating agents. Examples include alpha-hydroxy acids, glycerin,
phospholipids, propylene glycol and urea. Some ingredients such as urea also soften keratin. Because they draw
water and hydrate the skin, they are more efficacious for dry skin than emollients, which merely trap water present
on the skin. Regular use of hydrating agents decreases the need for topical corticosteroids.78,79
Alpha-hydroxy acids (e.g., lactic, citric, glycolic, malic, pyruvic and glucuronic acids) may increase biosynthesis of
mucopolysaccharides, contributing to the natural control of keratinization. Concentrations of 2–5% applied twice
daily are best for use on larger areas or on the whole body as these compounds may produce irritation at
concentrations of 10% or higher.80 Alpha-hydroxy acids affect keratinization at the lowest levels of the stratum
corneum, where they affect corneocyte cohesion and new stratum corneum formation. In addition, they increase
dermal mucopolysaccharides and collagen formation. Products such as lactic acid have been shown to increase
skin surface lipids, extensibility and firmness of the skin, improving skin barrier function.20
Glycerin is a humectant that helps keep the product moist and facilitates spreading. In optimal concentrations of
50% or less, glycerin helps retard water evaporation, keeping it in close contact with the skin. There is no evidence
that glycerin is absorbed through the skin.
Phospholipid products contain lecithin, which hydrolyzes to yield oleic, palmitic and stearic fatty acids. Lecithin is
a water-binding agent that occurs naturally in the skin. Each phospholipid molecule forms a complex with 15
molecules of water. Water is drawn to and kept in the skin for hydration, keeping it soft and resilient. These
preparations may also contain mineral oil, glycerin and lanolin.
Propylene glycol is a viscous, colourless, odourless, hygroscopic liquid used as a solvent and vehicle for water-
insoluble or unstable compounds. The pH may vary from 4–8 with these products and an acid pH may result in an
irritant reaction. A small percentage of patients may be hypersensitive to propylene glycol.
Urea works mainly by drawing water into the stratum corneum, though there are claims of keratolytic, antifungal,
antipruritic, anesthetic and anti-infective properties. It is used mainly in atopic dermatitis for xerosis, as application
on open, excoriated areas results in burning and discomfort. It can improve skin barrier function and reduce skin
susceptibility to irritants. The concentration of urea determines its effect. Concentrations of 10% hydrate dry skin
and 15% accelerate fibrin digestion. Concentrations of 20–30% are antipruritic, break down keratin, decrease the
thickness of the stratum corneum and are used in scaling conditions such as ichthyosis. Concentrations of 40%
are proteolytic and may be used to dissolve and peel dystrophic nails. Urea is sometimes combined with other
active ingredients, such as corticosteroids, anthralin and benzoyl peroxide, to accelerate skin penetration.
Combinations with hydrocortisone are useful for the dry itching skin of atopic dermatitis.81
Barrier Repair Products
Recognition of the role of disrupted ceramide content in barrier dysfunction led to the development of barrier repair
therapies that aim to restore appropriate ceramide balance. In one study, a ceramide-dominant product was as
effective as a mid-potency topical corticosteroid after 28 days.82 The use of barrier repair products containing key
stratum corneum lipids, including ceramides may make it possible to reduce the use of topical corticosteroids and
immunosuppressive agents such as tacrolimus and pimecrolimus.
Tar Preparations
Topical coal tar derivatives have been used for many years in the treatment of inflammatory skin diseases. Coal tar
activates the aryl hydrocarbon receptor signaling pathway, resulting in enhanced epidermal differentiation,
increased levels of filaggrin, and inhibition of a major atopic dermatitis cytokine pathway.83 Prior to the widespread
use of corticosteroids, crude coal tar extracts were used to reduce inflammation in atopic dermatitis. Despite
limited evidence of efficacy, tar preparations72 may be used to reduce the need for corticosteroids in chronic
maintenance therapy of atopic dermatitis. Their effect is not felt to be as potent as corticosteroids but they are
long lasting with few side effects. Coal tar is primarily used in scalp preparations, compounded in cream bases
that are generally used at night to increase adherence. Patients should cover the head with a shower cap to limit
staining, and rinse out in the morning. Coal tar products should not be used on inflamed skin due to irritating
effects. Cosmetically, they are less acceptable due to staining and unpleasant smell.20
Topical Corticosteroids
Topical corticosteroids are the mainstay of treatment for atopic dermatitis and first-line treatment for patients with
allergic contact dermatitis. They reduce inflammation and pruritus and are useful for both the acute and chronic
phases of atopic and contact dermatitis. Their mechanism is complex, affecting multiple resident and infiltrating
cells primarily by suppressing inflammatory genes.
A large number of topical corticosteroids are available, ranging in potency from low to extremely high. A variety of
factors should be considered when choosing a particular topical corticosteroid, including patient age, areas of the
body to which the medication will be applied, and other patient factors such as degree of xerosis, patient
preference, and cost of medication. Low-potency choices are recommended for areas of thinner skin (particularly
the face and eyelids) and high-potency products are indicated for thickened and lichenified lesions in other
locations. Choice of vehicle for the corticosteroid is also important. Vehicles include lotions, solutions, gels,
sprays, foams, and oils. In general, ointments are considered more potent and more occlusive and contain less
preservatives than creams and lotions. Creams are better tolerated in excessive heat or humidity; lotions are less
effective and contribute to xerosis. Solutions are used on the scalp or hairy areas, but the alcohol content may
irritate inflamed or excoriated lesions.
As a general rule, the lowest potency corticosteroid that is effective should be used. Therapy should not exceed a
2-week course. Lack of response to low-potency agents such as hydrocortisone may indicate the need for stronger
corticosteroids except on the face and in skin folds, where low-potency agents like hydrocortisone remain the
drugs of choice.84,85 Using a topical corticosteroid too low in potency may sometimes result in persistence or
worsening of atopic dermatitis. In such cases, after a 2-week trial, institute a stepped-care approach, beginning
with a mid-to-high potency corticosteroid until control is achieved, and then reducing to a lower-potency agent.
Discontinuing a mid- to high-potency corticosteroid without tapering to a lower-potency corticosteroid may result
in rebound flaring of atopic dermatitis. Some patients may not respond to corticosteroid therapy due to
superinfection.20 When topical corticosteroids are used, any coexisting infection should be treated promptly.
Application of topical corticosteroids to wet skin has not been demonstrated to be better than application to dry
skin for children with atopic dermatitis.86 However, in cases where topical corticosteroid alone is inadequate, this
‘‘soak and smear’’ technique may improve response.72,87 Severe or complicated dermatitis may require treatment
with stronger corticosteroids. Resistant cases may sometimes respond to the addition of occlusion to the
application of the corticosteroid, but this approach should be used with caution and is generally reserved for
dermatitis of the hands or feet.
Patients with atopic dermatitis should be advised to continue with moisturizer therapy during treatment with
topical corticosteroids. Topical corticosteroids should be used once daily although if insufficient for control, twice
daily can be used. Twice weekly maintenance therapy is recommended in patients with moderate to severe atopic
dermatitis experiencing frequent relapses and is more effective than use of moisturizers alone for prevention of
flares.72 There is insufficient evidence to know whether it is more beneficial to apply moisturizers before or after
topical corticosteroids. A small, randomized study showed no difference over 2 weeks between patients who
applied moisturizer before topical corticosteroids and those who did the reverse.88 Many sources suggest
moisturizer be applied 30 minutes before topical corticosteroid but this is based on low-level evidence or
consensus recommendations and is not universally accepted. Practicality and patient adherence are key factors to
consider when deciding on order of application.89
Physical examination for cutaneous side effects is recommended during long-term, potent corticosteroid therapy.
Consider the potential for both topical and systemic side effects, including possible hypothalamic-pituitary-adrenal
axis suppression, particularly in children. Patient fears of side effects associated with the use of topical
corticosteroids for atopic dermatitis should be recognized and addressed to improve adherence and avoid
undertreatment. Despite widespread use, with correct education, adverse effects are infrequent with appropriately
used mid- to high-potency corticosteroids. Over time, antiproliferative effects (e.g., skin thinning), poor wound
healing, hypopigmentation, secondary infections and acne may occur, particularly on the face and in the
intertriginous areas. Perioral dermatitis may occur on the face, characterized by erythema, scaling and follicular
papules and pustules around the mouth or eye creases. Discontinue the corticosteroid if this occurs, and taper
using hydrocortisone. Hydrocortisone is always the drug of choice in these sites. Use of “steroid sparers” such as
emollients, occlusives and hydrators help to reduce total corticosteroid exposure, thereby reducing the risk of
adverse effects.
It is possible to develop an allergic sensitivity to corticosteroid preparations themselves which appears paradoxical
due to the anti-inflammatory effects of the corticosteroids. However, delayed-type reaction to corticosteroids do
occur.90 Reported incidence rates in positive patch test results ranged from 0.5%– 3% for various topical
corticosteroids in one study.91 Nonresponding eczema, development of subacute contact dermatitis, systemically
reactivated allergic contact dermatitis or maculopapular exanthems can be a clinical symptom of a delayed-type
hypersensitivity reaction to corticosteroids. The anti-inflammatory nature of corticosteroids makes the diagnosis
of allergy more difficult, but it should be considered in patients suffering from intractable dermatitis. Immediate-
type hypersensitivity reactions to corticosteroids remain uncommon.
Systemic Corticosteroids
Systemic agents are reserved for severe, acute cases, such as extensive poison ivy/oak; when treating poison
ivy/oak, a prolonged course of oral therapy with a slow taper is often required. In general, prolonged use of oral
agents for other causes is to be avoided due to adverse effects including diabetes, hypertension, growth
retardation, lymphopenia, bone loss, glaucoma/cataracts, and development of Cushing syndrome.92
Topical Calcineurin Inhibitors
Topical calcineurin inhibitors (TCIs) such as tacrolimus and pimecrolimus are analogues of cyclosporine and have
anti-inflammatory effects. They are highly effective in improving dermatitis and pruritus. Tacrolimus was effective
in the treatment of corticosteroid-resistant allergic contact dermatitis in one study93 and as effective as a
moderate-potency corticosteroid in another.94 Tacrolimus and pimecrolimus have both been shown to be effective
for treatment of atopic dermatitis in children and adults.72,95 There is some evidence that tacrolimus may have a
greater effect than pimecrolimus over time.95,96,97,98 Topical calcineurin inhibitors may not be as effective as
moderate- to high-potency topical corticosteroids in the treatment of atopic dermatitis.95 Use of TCI therapy 2–3
times weekly between atopic dermatitis flares is recommended on flare-prone areas to help prevent relapses and
decrease the amount of topical corticosteroid needed.72
The most common adverse effect reported for TCIs is burning and stinging at the application site, particularly if
the skin is acutely inflamed. Treatment with topical corticosteroids to reduce inflammation prior to instituting TCI
therapy may help minimize these reactions.72 Concerns about increased risk of infections due to
immunosuppression may warrant avoiding use on actively infected skin. There is insufficient evidence to support
concerns about any link between use of TCIs and risk of malignancy. Routine bloodwork is not recommended.57,72
TCIs are usually considered second-line therapy when topical corticosteroid therapy is ineffective or not tolerated.
The major advantage of TCIs is their safety profile and tolerability. They are recommended as steroid-sparing
options for long-term topical treatment. They may be safely used in sensitive or thin-skinned areas such as the
face, anogenital region and skin folds. 72
Topical Anti-Infectives
Atopic individuals are predisposed to skin infections because of a compromised physical barrier. S. aureus is found
in more than 90% of atopic dermatitis. A systematic review examined 26 randomized controlled trials that used a
variety of antistaphylococcal treatments in the management of atopic dermatitis, including oral antibiotics,
antibacterial soaps, topical antibiotics or antiseptics, special textiles and combinations of topical corticosteroids
with antibacterials. While reduction of S. aureus counts on the skin was reported with some interventions, no trials
showed improvement in eczema control. The poor quality of many of the studies and low patient numbers make
this evidence difficult to interpret.99 Topical antimicrobial preparations are not generally recommended in the
treatment of atopic dermatitis. They can be associated with contact dermatitis, and there is concern that their use
could promote wider antimicrobial drug resistance. Oral antibiotics are not indicated for routine treatment in
noninfected atopic dermatitis.72
Bleach baths may be helpful in cases of moderate to severe disease with frequent bacterial infections, particularly
for maintenance because the majority of patients do not show clearance of the bacteria. Development of bacterial
resistance is less of a concern with use of dilute bleach compared with the use of topical and systemic antibiotics.
Topical hypochlorite products are also available but are more expensive and have not been studied specifically.72
Treatment with antifungal agents is sometimes used to address dermatophyte pathogens such as Malassezia in
atopic dermatitis, but the response to these is less effective than treatment with topical corticosteroids.20
Antihistamines
Pruritus is the hallmark of atopic dermatitis and a frequent symptom of contact dermatitis. The itch-scratch cycle
complicates atopic dermatitis and should be aborted. Oral antihistamines act by blocking H1-receptors, thereby
reducing pruritus caused by histamine. However, pruritus associated with atopic dermatitis is thought to be caused
by mediators other than histamine, which is not the key factor.100 Certain subgroups of patients may benefit from
antihistamines for other reasons. The first subgroup are those with sleep disturbances. The benefit of
antihistamines comes from their side effects. First-generation antihistamines cause drowsiness which may help
patients with atopic or contact dermatitis (adults and children) by promoting sleep or affecting sleep disturbances
in the presence of pruritus. In these situations, first-generation antihistamines should be used before going to
sleep.100 For a second subgroup with comorbid conditions of the atopic diathesis, including allergic rhinitis,
chronic urticaria, dermographism or allergen-induced asthma, second-generation antihistamines such as
loratadine and desloratadine can be tried. Fexofenadine has demonstrated a small but significant reduction in
pruritus in atopic dermatitis, and may be the first option for patients who do not fall into the previous 2
subgroups.101 See Allergic Rhinitis for more information regarding oral antihistamines.
Topical antihistamines are strong contact sensitizers. In addition, due to the ionization that occurs topically, they
are not efficacious when applied to normal skin unless to mucous membranes. They have demonstrated little
utility and for these reasons, and due to the increased efficacy of other agents, they should be avoided.
An approach to the treatment of atopic dermatitis is shown in Figure 2. An approach to the treatment of contact
dermatitis is shown in Figure 3.
Natural remedies may not be harmless and should not be recommended over traditional, standardized and proven
therapies. At this time, there are little data to support the majority of complementary therapies tried for atopic
dermatitis management. Chinese herbal therapy (or traditional Chinese medicine) has been the most extensively
studied. Anti-eczematous efficacy of traditional Chinese herbal medicines was found in one study.102 While it may
have some benefit for lesions, the results from randomized controlled trials of oral therapy are conflicting, and
reports of serious hepatotoxicity raise potential safety concerns. Some preparations have been reported to cause
fatal toxic reactions, and adulteration with other substances such as corticosteroids has also been reported.103,104
The individualized and dynamic nature of this intervention (a different herb is added or subtracted depending on
the patient) also poses challenges to performing controlled studies. Acupuncture alone or in conjunction with
traditional Chinese medicine decreases signs and symptoms of atopic dermatitis, but the evidence is confined to
small studies of limited quality.105,106
The disturbed epidermal barrier function of atopic dermatitis has been linked to altered metabolism of unsaturated
fatty acids. This is the theoretical rationale for treatment with essential fatty acids such as gamma-linolenic acid
(evening primrose oil). Use is characterized by a low incidence of side effects but also low efficacy in adults, with
results in children no better than placebo. Two potential problems associated with use of evening primrose oil are
its high cost and the lack of product standardization; adulterated brands may simply contain corn oil. Its use is
clinically unsubstantiated and should not be recommended.7 A Cochrane review found no improvement in
symptoms of atopic eczema or quality of life with use of borage oil or evening primrose oil compared with
placebo.107
Massage therapy may improve symptoms of atopic dermatitis and associated patient and parental anxiety levels.
While it is a safe intervention, studies to date are small and of limited quality, precluding recommendation at this
time.108,109 Other complementary therapies lacking sufficient evidence include: aromatherapy, homeopathy,
naturopathy,110 acupressure111 and autologous blood injections.112
In the case of allergic contact dermatitis due to nickel sensitivity, some effects of nickel may be eliminated or
reduced by supplementing with divalent essential metals as there is some evidence that nickel dermatitis
improved following oral administration of zinc sulfate.113,114
Table 7 provides a monitoring framework for patients with dermatitis, which should be individualized. Parameters
should be monitored by the patient or the caregiver, and a diary can be used. Therapy should be appropriately tapered
in response to improvement or resolution. The healthcare practitioner should be responsible for ensuring that the
treatment plan remains on schedule and is effective, and no adverse effects are occurring. Changes in symptoms due
to treatment can be correlated with alterations in trigger factors such as irritants and foods. Stress, anxiety or
depression levels should be tracked if they are suspected aggravating factors, and may lessen as skin symptoms
improve.
Table 7: Monitoring of Therapy for Atopic, Contact or Stasis Dermatitis

Type of Dermatitis Parameter Timeframe/Degree of Change Actionsa
Acute Inflammation Decrease by 50% within 7–10 Taper therapy in response

(redness, swelling, days to resolution: if endpoints
pain, warmth) not achieved, consider
additional or different
therapy.
Surface area No progression
involved
Extension to other None

sites or
generalization
Blister formation No new blisters after 1–2 days
Itch/scratching Control to tolerable level within

7–10 days
Disruption of sleep Restoration of normal patterns

or daily activities within 2–3 wk
Stress, anxiety, Re-establish normal pattern

depression within 2–3 wk
Chronic Changes in Control by 4–8 wk If endpoints not achieved,

inflammation, consider additional or
scaling, dryness, different therapy.
itch, scratching
Progression of No progression of severity

severity
Recurrent episodes Lengthening of symptom-free

periods throughout therapy
Lichenification No further lichenification

throughout therapy
Acute and chronic Allergic reactions None If allergic reaction occurs,

discontinue therapy.
Severe dryness, Minimal If severe, decrease dose,

irritation (e.g., Should disappear, diminish or be concentration or
redness, controlled with continued use frequency of use.
inflammation, If still no improvement,
stinging) consider different therapy.
a
Patients should monitor all parameters daily while on drug therapy. Healthcare practitioners should monitor all parameters
after 7–10 days for acute dermatitis and after 2–3 weeks for chronic dermatitis.
Algorithms
Figure 1: Assessment of Patients with Dermatitis

Abbreviations: BSA = body surface area
Figure 2: Treatment of Atopic Dermatitis
Figure 3: Treatment of Contact Dermatitis

Drug Table
Table 8: Selected Self-care Topical Products for Dermatitisa
Class Drug Dosage Adverse Comments Costb
Effects
Barrier repair products ceramides/cholesterol/free Apply thin After Do not apply $$

fatty acids layer to application, a within 4 h
EpiCeram Skin Barrier affected temporary prior to
Emulsion, others area BID or tingling radiation
prn sensation may therapy.
occur (lasting
10–15 min).
Bath Products bath oils After bath Allergic Acts as a $

Keri Oil, others apply 5 mL sensitization barrier to
of oil in 50 may occur due reduce water
mL water to lanolin, loss.
with a fragrance and
cotton swab other contact
while the sensitizers.
skin is still May make the
damp bathtub
slippery.
Bath Products colloidal oatmeal As per Can clump and Provides $

Aveeno Bath Preparations, product clog drain. relief for
generics instructions; itching skin.
must be May contain
properly oils and can
dispersed in act as an
water to be emollient.
effective
Effects
Cleansers opaque soaps Rinse well Drying. May contain $

Lowila, others after moisturizers.
washing Use
In atopic fragrance-
patients, free soap if
restrict to possible.
axillae and
groin
Cleansers soapless cleansers Apply and Minor irritation Thin layer of $

Spectro Jel, others rinse seen rarely. product is
left on skin
allowing for
retention of
water.
Cleansers transparent soaps Rinse well May be less More water $

Pears, Neutrogena, others after drying than soluble but
washing opaque soaps. not as
In atopic effective as
patients, other
restrict to cleansers.
axillae and Use
groin fragrance-
free soap if
possible.
Corticosteroids, hydrocortisone 0.5%, 1% Apply thin Mild to severe Temporary $

topical cream, lotion, ointment layer skin irritation. relief of
Cortate, Emo-Cort, Prevex sparingly Rarely, redness,
HC, generics BID–TID hypersensitivity pain,
PRN reactions. swelling and
Reassess itch.
after 2 wk
Emollientsc emollients Examples: Apply PRN Allergic Retards $

glycol, glyceryl stearate, several sensitization evaporation
soy sterols times daily, may occur if of water.
Glaxal Base, Keri Lotion, preferably contains As oil
Lubriderm, Neutrogena while skin is lanolin, content
Cream damp selected increases
preservatives, becomes
fragrance and more
other contact occlusive.
sensitizers. Use
fragrance-
free
products if
possible.
Effects
Humectants/Hydrating humectants Examples: Apply PRN Allergic Humectants $

agentsc alpha-hydroxy acids several sensitization are usually
(glycolic acid, lactic acid), times daily, may occur if incorporated
glycerin, phospholipids preferably contains into an
(lecithin), propylene glycol, while skin is lanolin, emollient
urea damp selected base to form
Dermal Therapy, Lac- preservatives, hydrating
Hydrin, Neostrata, Uremol fragrance and agents. The
other contact emollient
sensitizers. base
prevents
water
evaporation
and the
humectants
attract water
into skin.
Occlusivesc occlusives Examples: Apply PRN Well tolerated, Used to $

petrolatum, dimethicone, several usually less protect
mineral oil times daily stinging than against
Barriere, Complex 15, with emollient irritants such
Moisturel, Prevex, Vaseline creams or as
lotions or chemicals,
humectant- detergents,
containing polishes and
hydrating water.
agents Also useful
for
prevention
and
treatment of
occupational
hand
eczema.
a
For more information on the use of topical corticosteroids consult the Compendium of Therapeutic Choices: Atopic Dermatitis.
c Most moisturizers contain combinations of emollients, humectants and occlusives.
Legend: $ <$10 $$ $10–20
Suggested Readings
Cury Martins J, Martins C, Aoki V et al. Topical tacrolimus for atopic dermatitis. Cochrane Database Syst Rev
2015;7:CD009864.
Eichenfield LF, Tom WL, Chamlin SL et al. Guidelines of care for the management of atopic dermatitis: section 1.
Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol 2014;70:338-51.
Eichenfield LF, Tom WL, Berger TG et al. Guidelines of care for the management of atopic dermatitis: section 2.
Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol 2014;71:116-32.
Lynde C, Guenther L, Diepgen TL et al. Canadian hand dermatitis management guidelines. J Cutan Med Surg
2010;14:267-84.
Saji D, Asiniwasis R, Skotnicki-Grant S. A look at epidermal barrier function in atopic dermatitis: physiologic lipid
replacement and the role of ceramides. Skin Therapy Lett 2012;17:6-9.
Scottish Intercollegiate Guidelines Network. Management of atopic eczema in primary care: a national clinical guideline.
Edinburgh: SIGN; 2011. Available from: www.sign.ac.uk/pdf/sign125.pdf.
Bacterial Skin Infections: Impetigo, Furuncles and Carbuncles

Date of Revision: October 2016
Introduction
The skin has a remarkable ability to protect against the external environment. A number of protective
mechanisms are involved. The uppermost layer of the epidermis, the stratum corneum, provides a physical
barrier to invading organisms, and its constant shedding also protects against entrenchment of
microorganisms. Sebaceous glands secrete oily sebum providing an acidic pH of 5.5 that is unfavourable
for microbial growth. The normal flora of the skin competes with potential pathogenic organisms. An
effective immune system includes Langerhans' cells in the epidermis and mast cells and macrophages in
the dermis. Still, infections do occur, usually as a result of a break in the integrity of the skin. Other
predisposing conditions for microbial invasion include excessive exposure to water through sweating,
bathing, occlusion, increased skin temperature or scrubbing the skin. Common bacterial skin infections
include impetigo, furuncles and carbuncles.
Impetigo
Pathophysiology
Impetigo is a very common and highly contagious skin infection involving the uppermost portion of the
epidermis. Most cases occur in preschool-aged children but it can affect any age group. The infection is
usually spread through direct contact with the lesions or infected exudates and develops quickly at sites of
minor trauma; however, it can also develop on normal skin with no apparent contactant. Predisposing
factors for impetigo include varicella, insect bites, burns, scabies, atopic dermatitis, diabetes,
hypogammaglobulinemia and HIV infection.1 The spread of impetigo is promoted by factors such as
crowding, poor personal hygiene and warm, humid conditions. Impetigo is most often caused by
Staphylococcus aureus. Nonbullous impetigo can also be caused by Streptococcus pyogenes (also known as
group A beta-hemolytic Streptococcus). In a minority of cases, other strains such as group C and group G
streptococci may be involved.2,3,4 About 30% of the population is colonized with S. aureus in the anterior
nares and 10% in the perineum, which serve as a reservoir for infection. Patients who are colonized with S.
aureus on their skin may be at risk of recurrent infection.
There are 2 distinct clinical presentations of impetigo. Nonbullous impetigo presents as papules that
progress to small vesicles (blisters) surrounded by erythema (a reddened area). Over a few days, these
lesions become pustules that exude and eventually dry to leave a honey-coloured, adherent crust. Lesions
are often multiple, involve the central face or extremities, and may be associated with local adenopathy. The
lesions may be tender and slightly itchy. The less common form, bullous impetigo, is almost exclusively
caused by an exfoliating toxin-producing S. aureus phage group II.5 These toxins cause loss of cell adhesion
in the superficial epidermis, causing blisters.6 The lesions begin as a superficial vesicle then become very
large, flaccid, transparent blisters (bullae) filled with a clear yellow fluid that rupture after 3–5 days and leave
a thin varnish-like crust.5 There is no surrounding erythema. These lesions are typically found on the trunk,
extremities, axilla and intertriginous (skin-fold and diaper) areas most commonly affecting neonates and
young infants.1 Rarely (up to 5% of cases), streptococcal impetigo leads to acute glomerulonephritis as an
immunologic response to the presence of a nephritogenic strain of S. pyogenes. Topical and/or oral
antibiotic treatment of impetigo due to group A streptococcus does not prevent poststreptococcal
glomerulonephritis. Other infrequent complications of impetigo include cellulitis, lymphangitis, guttate
psoriasis, osteomyelitis, septic arthritis, pneumonia, septicemia and staphylococcal scalded skin
syndrome.7 Rheumatic fever is not a risk following streptococcal impetigo.8 (See photo, Impetigo).
Photo 1: Impetigo
Goals of Therapy
Treat causative organisms
Relieve symptoms and resolve lesions
Prevent the spread of infection
Patient Assessment
Table 1 provides a description and differential diagnosis of impetigo and furuncles and carbuncles.
9,10,11
Table 1: Characteristics and Differential Diagnosis of Selected Bacterial Skin Infections
Condition Distribution Lesion Differential Diagnosis
Nonbullous Face, arms or Primary lesions are Ecthyma: A crust but unlike
impetigo legs vesicles and pustules. impetigo, it is a deeper infection
Secondary lesions through the dermis causing
occurring later are ulcers and is usually found on
yellow or honey- the lower extremities.
coloured crusts, with Tinea corporis: Inflammatory
erosions and erythema pustules but unlike impetigo, has
surrounding the lesion. a central clearing and develops
more slowly. See Fungal Skin
Infections.
Herpes simplex, herpes zoster,
varicella and other blistering
disorders such as contact
dermatitis may be misdiagnosed
as impetigo. However, unlike
impetigo, these conditions have
vesicles that are initially clear
rather than honey-coloured.
Herpes usually recurs in the
same location on the skin. See
Viral Skin Rashes.
Contact or atopic dermatitis
typically produce marked
pruritus. See Atopic, Contact,
and Stasis Dermatitis.
Bullous impetigo Moist, Superficial vesicles Bullous pemphigoid: Vesicles

intertriginous rapidly progress to and bullae rapidly appear on
areas (axillae, large, flaccid bullae with itchy urticarial plaques.
neck folds, no surrounding Stevens-Johnson syndrome is a
diaper area) erythema. Upon rupture vesiculobullous disease
Occasionally, of bullae, oozing clear affecting skin, mouth, eyes and
trunk and yellow fluid dries to genitalia.
extremeties leave a varnish-like
crust. Thermal burns are localized. See
Burns.
Insect bites are itchy and
grouped. See Insect Bites and
Stings.
Furuncles and Hairy areas: Primary lesions are Acne vulgaris: Pus-filled nodules
carbuncles Face, back of inflammatory nodules and cysts on the face and upper
neck, buttocks around hair follicles. trunk, but other acne lesions
and axillae Secondary lesions are such as comedones, papules
pustular with drainage. and pustules are present. See
Acne.
Hidradenitis suppurativa:
Recurrent pustules and
exudative sinus tracts in the
areas of apocrine glands,
namely, the axillae and groin of
young women after puberty.
Impetigo is considered a self-limiting infection that typically heals without scarring over a 2- to 3-week time
frame. Antibiotic therapy provides a quicker resolution and prevents the spread of this contagious
infection.12,13
The toxin produced by the strain of S. aureus that causes bullous impetigo may spread through the blood to
cause a serious disorder called generalized staphylococcal scalded skin syndrome. This is more likely to
occur in young children, people with renal impairment or in those who are immunocompromised.5 Patients
with bullous impetigo, recurrent bouts of impetigo, or an infection of unknown etiology, require assessment
and treatment by an appropriate healthcare provider.
Prior to application of a topical antibacterial, impetigo crusts should be removed with warm water or saline
compresses or soap-and-water washes. Compresses applied for 10–15 minutes and repeated 3–4 times
daily, using a clean compress for each application, may hasten the healing process.9,10,11 Patients should
not manipulate the lesions as the infection could spread.
For further information on the therapy of impetigo consult, the Compendium of Therapeutic Choices:
Bacterial Skin Infections.
Ailments—Skin Care Products: First Aid.
Topical antibiotic therapy is considered the treatment of choice for patients with uncomplicated impetigo
localized to 2 or 3 small areas. Topical therapy eradicates isolated disease and limits transmission.
Compared with oral therapy, topical antibiotics have fewer side effects and a lower risk of bacterial
resistance.13 A variety of topical antibiotics are available but only mupirocin and fusidic acid have been
shown to be as effective as oral antibiotics in localized infections and they are considered first-line
options.13,14,15
Mupirocin acts by reversible inhibition of bacterial isoleucyl-transfer RNA synthetase.9 It is effective against
gram-positive organisms only. Mupirocin does not exhibit cross-resistance with other antibiotics. There are
documented cases of mupirocin-resistant streptococci15 and staphylococci16 and therefore widespread use
for minor infections is discouraged.
Fusidic acid is a protein synthesis inhibitor effective against gram-positive organisms only. Resistance is
also reported with this agent.12,13,15,17
Topical antibiotics containing various combinations of polymyxin B, bacitracin, gramicidin and neosporin
have been shown to be inferior to mupirocin and fusidic acid (see Table 4).13,14,18,19,20
Systemic antibiotic therapy should be considered if the condition is widespread, the patient is
immunocompromised or has valvular heart disease, there are signs of fever or bacteremia or there is a lack
of improvement after 24–48 hours of topical therapy.21 Oral therapy is also recommended as a means of
decreasing transmission in outbreaks. Empiric therapy should involve a 7-day regimen with coverage for
both streptococci and beta-lactamase–producing S. aureus. If cultures reveal streptococci as the sole
pathogens, penicillin should be used. Because most S. aureus strains are MSSA (methicillin-susceptible S.
aureus), amoxicillin/clavulanate, cefadroxil, cephalexin and cloxacillin are recommended options. If
infection with MRSA (methicillin-resistant S. aureus) is confirmed or suspected, doxycycline, clindamycin or
sulfamethoxazole/trimethoprim (SMX/TMP) is recommended; however, culture and antibiotic susceptibility
testing may be warranted to identify resistant strains of MRSA. Although there are few reports of clinical
failure, empiric use of SMX/TMP is limited by inadequate coverage of streptococci.3 Erythromycin and other
macrolides are not recommended as resistance rates are rising and GI adverse effects are frequent.3,13,14
Recurrent impetigo may occur when there is S. aureus carriage in the anterior nares or perineum. Recurrent
cases require culture and, if positive, treatment with a 5-day eradication regimen consisting of topical
mupirocin applied to the nares 2–3 times daily and daily washing with topical chlorhexidine or
hexachlorophene (particularly the perineum and axilla).3,21
Topical solutions including saline, hexachlorophene, povidone-iodine and chlorhexidine are inferior to
topical antibiotic therapy and are not recommended as sole therapy for impetigo.13,22
Avoid use of chlorhexidine solution on the face or scalp as it can be toxic to the middle ear in the presence
of a ruptured tympanic membrane and has the potential to irreversibly damage the cornea (causing
keratitis) with a minimal splash exposure. Povidone-iodine is a safe and effective alternative.23
Table 2 presents a monitoring framework for patients with impetigo. Lesions should begin to heal within 2–
3 days of starting therapy, and the patient is no longer infectious about 48 hours after the initiation of
treatment. Lesions usually heal without scarring. Further assessment and/or treatment is advised if lesions
spread, or if fever or other systemic symptoms arise. Given the increasing rate of community-acquired
MRSA, in nonresponsive cases a swab of the lesion or wound for culture and sensitivity is recommended.
Table 2: Monitoring of Therapy for Impetigo

Vesicles and crusts Patient: Daily while on Clearing of all lesions If worsening or no
therapy by 7–10 days. Return improvement by day
of normal skin 3, consider further
appearance within 2– assessment and/or
3 wk. treatment.
Bullous lesions Patient: Daily while on Clearing of all lesions. If worsening or no

therapy Return of normal skin improvement by day
Healthcare appearance within 2– 3, consider further
practitioner: After 3 3 wk. assessment and/or
days if no treatment.
improvement with
therapy
Reddish-brown or Patient: Daily while on No renal problems. Patient requires

“cola” coloured urine therapy and for weeks immediate
(possible indicator of following assessment for renal
post-streptococcal evaluation.
glomerulonephritis)
Postinflammatory Patient: Weekly after Resolution several Patient requires

pigmentary skin therapy is completed months after clearing further evaluation
change of initial infection. and/or treatment if
persisting.
Allergy to topical Patient: Daily while on No allergy. Stop therapy. Patient

agents therapy requires further
Healthcare assessment and/or
practitioner: After 1 treatment.
wk or next pharmacy
visit
Irritation caused by Patient: Daily while on Little to no irritation Stop therapy if no

topical agents therapy that subsides with improvement in
Healthcare continued use. irritation after several
practitioner: After 1 doses.
wk or next pharmacy
visit
.....
Furuncles and Carbuncles
Pathophysiology
Furuncles (boils) and carbuncles usually begin near hair follicles as a superficial folliculitis which consists of
yellowish pustules, then spreads to deeper layers of skin. Furuncles are most common in adolescence and
early adulthood; carbuncles occur more often in older males.11,24
Furuncles spread into the dermis to produce a painful and erythematous swelling with a central pustule. Pus
often drains spontaneously. Carbuncles penetrate deeper over a larger area than furuncles with involvement
of numerous adjacent follicles and extension into the subcutaneous fat. Hairy areas subjected to irritation
from perspiration or friction, such as the bearded area of the face, back of neck, buttocks and axillae, are
common sites of infection (see Figure 1).11,24
Furuncles and carbuncles are usually attributable to methicillin-susceptible or methicillin-resistant S. aureus.

Additional pathogens implicated in hair follicle infections include Pseudomonas, as in the usually benign
“hot-tub folliculitis”, oral anaerobes as seen among intravenous drug users, and Mycobacterium associated
with whirlpool footbaths at nail salons.25,26 (See photo, Folliculitis).
Figure 1: Folliculitis, Furuncle and Carbuncle

Photo 2: Folliculitis
iStockphoto
Predisposing factors for these infections include obesity, suppressed immune states, heat, friction,
occlusion and excessive sweating. Close contact with individuals with furunculosis appears to be a risk
factor for transmission.27 Risk factors for MRSA infection include sharing sports equipment, recent
hospitalization, residing in a long-term care facility, recent antibiotic therapy, HIV infection, men having sex
with men and intravenous drug use.24 Furuncles can progress to become carbuncles or cellulitis.
Carbuncles have the potential to cause bacteremia with resultant morbidity or mortality.7 Recurrent cases
can occur especially if S. aureus is present in a carrier state in the anterior nares or perineum.7,24
Goals of Therapy
Treat causative organisms
Relieve symptoms and resolve lesions
Prevent more serious infections
Patient Assessment
A description and differential diagnosis of furuncles and carbuncles is found in Table 1. Fever, malaise and
local adenopathy are more common in patients with carbuncles than furuncles. Patients who have a fever,
recurrent furuncles, carbuncles or an infection of unknown etiology require assessment and/or treatment by
an appropriate healthcare provider.
A furuncle is a fluctuant mass of walled-off purulent material that normally ruptures and drains pus
spontaneously. Warm water or saline compresses applied for 20–30 minutes 3 or 4 times daily may
promote spontaneous drainage and help relieve discomfort.10,11 Washing the area with soap and water or
chlorhexidine 4% four times daily to reduce the S. aureus colony counts is advised.28,29 Avoid inadvertent
splashing of chlorhexidine solution into eyes or ears (see Impetigo, Pharmacologic Therapy). To prevent
transmission, lesions should be covered with a sterile dressing and not touched. Personal items contacting
the lesion should be washed daily in hot water and not shared. Carbuncles, and furuncles that are large or
unresponsive to warm compresses, usually require surgical incision and drainage.11 Some spontaneously
draining lesions may not drain adequately and may require incision and drainage.
Many patients with furuncles or carbuncles benefit from incision and drainage alone;3 the role of ancillary
antibiotics is unclear.30 Oral antibiotics should be considered in the following situations: inadequate clinical
response to incision and drainage, multiple lesions, extensive surrounding cellulitis, associated
comorbidities, immunosuppression or systemic signs of infection (fever, tachypnea, tachycardia,
leukocytosis).3
Empiric treatment with oral antibiotics should cover MRSA; sulfamethoxazole/trimethoprim (SMX/TMP),
doxycycline, minocycline and clindamycin are appropriate options. If culture results are available, therapy
should be guided by local antibiograms. Cephalexin or cloxacillin is appropriate for infections where
cultures have shown MSSA to be the cause.3,31
Parenteral antibiotic therapy is indicated in immunocompromised patients and in patients who fail initial
antibiotic therapy combined with incision and drainage and exhibit signs of severe systemic infection such
as temperature >38°C, tachycardia >90 beats per minute, tachypnea >24 breaths per minute, white blood cell
count >12 000 or <400 cells/µL, or hypotension.3 For more information on the treatment of bacterial skin
infections with oral or parenteral antibiotics, consult the Compendium of Therapeutic Choices: Bacterial Skin
Infections.
Some patients have recurrent furuncles or carbuncles. It is unknown whether the risk of recurrent infection
is decreased or whether the prevalence of resistance is increased with use of antibiotics in addition to
incision and drainage.24,32,33 Recurrent furuncles or carbuncles should be treated for 5–10 days with
antibiotics active against the identified pathogen. In addition, local causes of recurrent infection such as
foreign material, pilonidal cyst or hidradenitis suppurativa should be ruled out. Adult patients with recurrent
abscesses since childhood should be evaluated for neutrophil disorders. Encourage meticulous personal
and environmental hygiene measures. Recommend MRSA decolonization when there are multiple
documented recurrences of MRSA infection or if ongoing transmission is occurring among household
members or other close contacts despite optimal hygiene. Intranasal application of mupirocin ointment
twice daily for 5 days each month for 3 months combined with chlorhexidine antiseptic washes daily for 5–
14 days is recommended in spite of weak supportive evidence.3,31 Avoid inadvertent splashing of
chlorhexidine solution into eyes or ears (see Impetigo, Pharmacologic Therapy). Dilute bleach baths may be
considered as a means of reducing S. aureus infections,3,31 although limited evidence has not demonstrated
significant clinical benefit in atopic dermatitis patients34 or children with recurrent skin and soft tissue
infections.35
After spontaneous or surgical drainage, healing usually occurs within a week. Large lesions may heal with a
scar. Patients with recurrent infections may have underlying systemic illnesses that require investigation
and management. A monitoring framework for patients with furuncles or carbuncles can be found in Table
3.
Table 3: Monitoring of Therapy of Furuncles/Carbuncles

Boils and pus Patient: Daily while on No more drainage of If no improvement or

therapy pus, and lesions heal worsening by day 3,
over several weeks. patient requires further
assessment and/or
treatment.
Fever Patient: Daily while on Return to normal body If no improvement by

therapy temperature. day 2, patient requires
Healthcare practitioner: further assessment
After 48 h and/or treatment.
Pain on palpation Patient: Daily while on Relief of pain as the If no improvement or

therapy lesion heals. worsening by day 3,
patient requires further
assessment and/or
treatment.
Recurrent lesions Patient: Watch for any No recurrent infections. Patient requires culture
new lesions for weeks of anterior nares and
and months following perineum.
the initial lesions Patient may require
assessment and/or
treatment for
underlying causes of
recurrence.
Allergy to topical Patient: Daily while on No allergy. Stop therapy. Patient

agents therapy requires further
Healthcare practitioner: assessment and/or
After 1 wk or next visit treatment.
Irritation caused Patient: Daily while on Little to no irritation Stop therapy if no

by topical agents therapy that subsides with improvement in
Healthcare practitioner: continued use. irritation after several
After 1 wk or next visit doses.
.....
Drug Table
Table 4: Topical Antibacterial Agents for the Treatment of Impetigo
Class Drug Dosagea Adverse Comments Costb
Effects
Antibiotics, bacitracin Apply Common Less $

topical Bacitracin USP, generics 1–3 cause of effective
times allergic than fusidic
daily for contact acid or
up to 7 dermatitis mupirocin.
days or Spectrum:
until all Gram-
lesions positive
are only.
healed Stable only
in
petrolatum
(ointment).
Class Drug Dosagea Adverse Comments Costb
Effects
Antibiotics, fusidic acid Apply Rare: Mild First-line $$$

topical Fucidin BID–TID irritation, treatment
× 5 days allergic option.
or until contact Spectrum:
all dermatitis Gram-
lesions positive
are only.
healed
Antibiotics, mupirocin Apply Infrequent: First-line $$

topical Bactroban, generics BID–TID burning, treatment
× 5 days stinging option.
or until Rare: Spectrum:
all Allergic Gram-
lesions contact positive
are dermatitis only.
healed
Antibiotics, bacitracin/neomycin/polymyxin Apply Neomycin Less $

topical B TID × up and effective
Neosporin Ointment, generics to 7 bacitracin than fusidic
days or components acid or
until all are mupirocin.
lesions common Spectrum:
are causes of Gram-
healed allergic positive
contact and gram-
dermatitis negative.
Rarely
nephrotoxic
when
applied to
large
denuded
areas.
Antibiotics, bacitracin/gramicidin/polymyxin Apply Bacitracin Less $

topical B TID × up component effective
Polysporin Products, generics to 7 is a than fusidic
days or common acid or
until all cause of mupirocin.
lesions allergic Spectrum:
are contact Gram-
healed dermatitis positive
and gram-
negative.
Rarely
nephrotoxic
when
applied to
large
denuded
areas.
a Reassess if there is a lack of improvement after 48 hours of topical therapy.

b Cost of 15 g; includes drug cost only.
Legend: $ <$5 $$ $5–10 $$$ $10–15
Suggested Readings
Hartman-Adams H, Banvard C, Juckett G. Impetigo: diagnosis and treatment. Am Fam Physician
2014;90:229-35.
Liu C, Bayer A, Cosgrove SE et al. Clinical practice guidelines by the Infectious Diseases Society of America
for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect
Dis 2011;52:e18-55.
Stevens DL, Bisno AL, Chambers HF et al. Practice guidelines for the diagnosis and management of skin and
soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis
2014;59:e10-52.
References
1. Hartman-Adams H, Banvard C, Juckett G. Impetigo: diagnosis and treatment. Am Fam Physician

2014;90:229-35.
2. DermNet NZ. Impetigo. Available from: www.dermnetnz.org/bacterial/impetigo.html. Accessed April
20, 2016.
3. Stevens DL, Bisno AL, Chambers HF et al. Practice guidelines for the diagnosis and management of
skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin
Infect Dis 2014;59:e10-52.
4. Baddour LM. Impetigo. Available from: www.uptodate.com. Accessed July 2015. Subscription
required.
5. Amagai M, Matsuyoshi N, Wang ZH et al. Toxin in bullous impetigo and staphylococcal scalded skin
syndrome targets desmoglein 1. Nat Med 2000;6:1275-7.
6. Amagai M, Yamaguchi T, Hanakawa Y et al. Staphylococcal exfoliative toxin B specifically cleaves
desmoglein 1. J Invest Dermatol 2002;118:845-50.
7. Morelli JG. Cutaneous bacterial infections. In: Kliegman R, ed. Nelson textbook of pediatrics. 18th ed.
Philadelphia: Saunders; 2007.
8. Bisno AL, Stevens DL. Streptococcal infections of skin and soft tissues. N Engl J Med 1996;334:240-
5.
9. Burd RM, Sladden M. Impetigo. In: Lebwohl MG, Heymann WR, Berth-Jones J et al., eds. Treatment of
skin disease: comprehensive therapeutic strategies. 4th ed. Edinburgh: Elsevier/Saunders; 2014.
10. Marks JG, Miller JJ. Lookingbill and Marks’ principles of dermatology. 5th ed. London:
11. Craft N. Superficial cutaneous infections and pyodermas. In: Goldsmith LA, Katz SI, Gilchrest BA et
al., eds. Fitzpatrick's dermatology in general medicine. 8th ed. New York: McGraw-Hill; 2012.
12. Feaster T, Singer JI. Topical therapies for impetigo. Pediatr Emerg Care 2010;26:222-7.
13. Koning S, van der Sande R, Verhagen AP et al. Interventions for impetigo. Cochrane Database Syst
Rev 2012;1:CD003261.
14. George A, Rubin G. A systematic review and meta-analysis of treatments for impetigo. Br J Gen Pract
2003;53:480-7.
15. Bangert S, Levy M, Hebert AA. Bacterial resistance and impetigo treatment trends: a review. Pediatr
Dermatol 2012;29:243-8.
16. Hetem DJ, Bonten MJ. Clinical relevance of mupirocin resistance in Staphylococcus aureus. J Hosp
Infect 2013;85:249-56.
17. Sutton JB. Efficacy and acceptability of fusidic acid cream and mupirocin ointment in facial
impetigo. Curr Ther Res 1992;51:673-8.
18. Noah S. A primer in topical antibiotics for the skin and eyes. J Drugs Dermatol 2008;7:409-15.
Burns
Nancy Kleiman, BSP, MBA

Pathophysiology
Burns encompass a spectrum of tissue injury (see Table 1) with cell death and protein denaturation caused
by:1,2
heat (thermal burns), e.g., flame, scalding liquids, hot objects, gases
radiation, e.g., sun, ultraviolet (UV) lamps, lasers
electricity, e.g., lightning, home appliances
chemical exposures, e.g., caustic cleaners, solvents, laboratory reagents.
The potential seriousness of the burn is related to:1,2
body location and skin thickness

temperature of the causative agent
type of causative agent
duration of exposure to causative agent
extent of the burn
depth of the burn (particularly affects healing time and potential sequelae of scarring and
contractures).
Patient factors that increase the risk of burn wound infections or delayed burn healing include:1,2
age (very young or elderly)

underlying medical conditions such as diabetes or vascular disease
malnutrition
smoking
drug therapy that suppresses the immune system.
Characteristics of burn wounds are summarized in Table 1. (See photos: Superficial Burn, Deep Partial
Thickness Burn and Full Thickness Burn).
Photo 1: Superficial Burn (scalded thigh)

Photo 2: Deep Partial Thickness Burn (4 yr old child's hand)
Scott Camazine/First Light
Photo 3: Full Thickness Burn (woman's finger)
St. Stephen's Hospital/Science Photo Library
1,2,3
Table 1: Characteristics of Burn Wounds
Old Class Examples Appearance Healing
Nomenclature
First-degree Superficial Sunburn; very Dry; pink; 3–5 days; no

(epidermis only) brief thermal blanches with scarring
contact; low- pressure; painful;
intensity heat some edema; no
blisters; skin
remains intact so
infection is not a
concern
Second- Superficial Scald (spill, Moist; weeping; 7–21 days;

degree partial splash); brief red; small blisters; scarring unusual;
thickness flame; thermal blanches with potential pigment
(epidermis, contact or pressure; extreme changes
upper dermis) exposure to dilute pain
chemicals
Deep partial Scald; oil or Wet or waxy; dry; >21 days; risk of
thickness grease; flame; colour variable scarring and
(epidermis, prolonged (red, patchy contracture
deep dermis exposure to dilute white); blisters
with some hair chemicals may be present;
follicle, sweat no blanching with
gland damage) pressure; pain
only with pressure
Third-degree Full thickness Scald Dry; waxy white to Never heals

(epidermis, (immersion); leathery gray to spontaneously;
dermis to steam; flame; charred and black; requires
subcutaneous concentrated no blanching with surgery/grafts;
layer) chemicals; high- pressure; painless high risk of
voltage electrical (due to scarring;
destruction of contractures;
nerves) systemic and skin
infection; fluid loss
The extent and seriousness of partial-thickness to full-thickness burns, and thus their appropriate treatment,
is determined in part by estimating the total body surface area (TBSA) affected by the burn. One way of
measuring the extent of the burn is referred to as the “rule of nines”3 (see Table 2). This estimation is best
done by an experienced burn specialist in a hospital setting. Superficial burns are not included in TBSA
calculations of burn wounds and are generally self-treatable. Partial- and full-thickness burns in adults that
are >10% TBSA, or in children that are >5% TBSA, should be assessed in a hospital setting.4
3,5
Table 2: Assessing Extent of a Burn—Rule of Nines
% of Body Surface Area % of Body Surface Area
Body Part (Adult) (Infant/small child)
Head 9 18
Both arms 18 18
Anterior trunk 18 18
% of Body Surface Area % of Body Surface Area
Body Part (Adult) (Infant/small child)
Posterior trunk 18 18
Both legs 36 28
Palm of hands 1 1
Goals of Therapy
Minimize further damage from the suspected causative agent
Promote healing and restoration of damaged tissue
Prevent infection/complications
Control pain
Patient Assessment
Self-management is appropriate for most superficial burns or superficial partial-thickness burns (a few
small blisters with limited distribution on the body). Patients with burns of any size that are more serious
than the mildest partial-thickness burn (minimal blistering) should be seen in an emergency care setting.
Appropriate referral minimizes the risk of infection, fluid and electrolyte loss and scarring.
Assess patients to determine whether there is concomitant trauma (e.g., electrical injury causing cardiac
dysrhythmias).
Patients who have burns with minimal blistering should be seen in an emergency care setting if they involve
thin skin areas (e.g., face, ears, eyelids, inner surface of arm, perineum) or occur in individuals presumed to
have thin skin (e.g., children less than 2 years or adults older than 55 years).1,2
Electrical burns and chemical burns involving concentrated acid and alkali products should also be
assessed and treated in an emergency care setting even if they appear to be minor, since the injury may be
deeper than the initial appearance of the burn suggests and can progress to deep tissue necrosis within 24
hours.2
Patients with underlying conditions that put them at risk of infection or delayed healing, such as diabetes,
chronic alcohol abuse, immunocompromised states (including drug-induced immunosuppression), require
close monitoring and follow up.1,2
Assessment of burn patients is summarized in Figure 1.
Thermal burns are treated by removal of the causative agent to minimize further tissue damage. Cooling
can limit the extent of injury and provide some pain relief, and should be started as soon as possible.2
Thermal burns can be cooled for up to 30 minutes with tepid (cool to touch) tap water irrigations, immersion
in tepid water, or application of cool tap water compresses for up to 20 minutes (12°C).3,5 If the burn is
serious enough to require medical attention, continue with cool compresses during transport. Plastic cling
wrap can be used over the burn during transport to protect the area against fluid and heat loss and from
infection.4 Ice application is not recommended because it can cause vasoconstriction that may worsen the
injury and lead to frostbite.4,5
Chemical burns are treated by removing the causative agent and clothing that has become saturated with
the chemical. Irrigate the burn area with copious amounts of lukewarm or cool water and transport the
patient to the emergency room for further treatment.5
Electrical burns are treated by first removing the source of electricity if safely possible, and then
immediately transporting the person to the emergency room for further treatment as these burns are often
more serious than they appear.5
Radiation burns are commonly caused by sun exposure and are treated in a similar manner to a thermal
burn.
First Aid for Burns
First-aid treatment of burns is dependent on the type of burn and the causative agent. Superficial or
superficial partial-thickness burns caused by thermal agents or the sun are generally self-treatable, while
deep partial-thickness or full-thickness burns, or those with chemical or electrical causes, require immediate
medical attention.
To apply first aid for superficial burns:
Stop the process or cause of the burn by either removing the causative agent or removing the patient
from the source of the burn
Cool the burn area by running cool tap water (8–25°C) over the area for 20 minutes.4 Cooling the burn
helps to reduce pain and inflammation6 and may reduce the severity of tissue damage7
Remove jewelry or anything restrictive from the burned area quickly in case the area swells
Leave small blisters intact. If blisters break, gently clean the area with mild soap and water and cover
with nonadherent gauze dressing
The use of disinfectants to clean burn wounds is not recommended because they may impair wound
healing2
Tap water and mild soap can be used to gently clean secretions and remove wound debris with each
dressing change
Seek medical attention if the burn is >10% TBSA for adults or >5% TBSA for children, in those <2 or >55
years old or if there is involvement of face, ear, eyelid, palms, feet, inner surface of arms or perineum.
For more information on therapy for burns, consult the Compendium of Therapeutic Choices: Burns.
Ailments—Analgesic Products: Internal Analgesics and Antipyretics; Skin Care Products: Anesthetics,
Dermatitis and Dry Skin, First Aid.
Antibacterial Agents
Topical antibiotics are not recommended for routine use on minor burns unless infection is present.4 It
is important to monitor the patient for signs of infection and to treat if needed.6 Silver sulfadiazine
(SSD), a broad spectrum topical antibiotic, has historically been used to prevent burn wound infections.
However, limited poor quality evidence suggests that the use of SSD on superficial or partial thickness
burns may lead to poorer healing outcomes than other topical treatments.8,9
Oral antibiotics are not effective in preventing burn wound infections and should be used only when
there is a known active infection.10
Pain and Itch Control

Usual doses of nonprescription analgesics (e.g., acetaminophen, ibuprofen) are often sufficient to
control pain in minor burns. ASA should be avoided in superficial partial-thickness or deep partial-
thickness burns because platelet inhibition poses a risk of bleeding in the presence of open wounds.2
Deeper burns with open areas often require opioids for adequate pain management.2
Local anesthetics are a common ingredient in topical products marketed for the relief of minor pain and
itching associated with superficial burns. There is no evidence to substantiate their effectiveness.
Lidocaine and benzocaine commonly cause contact dermatitis, while pramoxine has low sensitizing
potential. There is a risk of systemic absorption if local anesthetics are applied to blistered or large areas
of skin. Camphor, menthol and phenol are counterirritants thought to have a cooling effect on the burned
area and to provide some relief from itching. However, there is no evidence available for the use of
counterirritants in the treatment of minor burns.
Deep partial-thickness and full-thickness burn wounds can take 6 months to 2 years to heal completely.
Itching is common during the healing phase, particularly in partial thickness burns. Moisturizing lotions
and colloidal oatmeal baths may provide symptomatic relief of itch in less severe burns. Systemic
antihistamines such as diphenhydramine, cetirizine and hydroxyzine may be helpful in some patients
whose itching is more bothersome.2 Some evidence indicates that gabapentin may be an option for
patients with itch that has not responded to moisturizers and antihistamines.11 Avoid the use of topical
antihistamines in this situation since the risk of sensitization and allergic contact dermatitis increases
with prolonged use. The area will also be more sensitive to sun and extremes of heat and cold. High SPF
(30 or greater) sunscreens should be used until the wound has healed completely, to prevent permanent
hyperpigmentation from repeated injury due to sun radiation.1,2 See Prevention and Treatment of Sun-
induced Skin Damage.
Other Agents
Topical honey appears to result in healing of partial thickness burns 4–5 days more quickly than some
conventional treatments, though differences in rates of adverse events or infection are unclear. There is
also uncertainty about the replicability and applicability of this evidence.12
A systematic review determined that evidence is inconclusive regarding whether aloe vera gel or
dressings improve outcomes for acute wounds including burns.13 Some patients experience mild side
effects of burning sensation, contact dermatitis or mild itching with topical application.14
Tetanus prophylaxis is recommended for deep partial-thickness and full-thickness burns if it has been
more than 10 years since the last booster. The Public Health Agency of Canada recommends that
tetanus prophylaxis also be implemented if it is uncertain when the patient's last booster was given, or if
the patient has not received the full 3 doses of the primary immunization series.15
Table 3 provides a monitoring plan for burn therapy.
Table 3: Monitoring of Therapy for Burns

Symptom Monitoring Endpoint Actions
Pain Monitor pain level The patient's worst Patients whose pain is not
every 4–6 h for the pain score should be responding adequately to
first few days and less than 5. Higher regular (Q4–6H) doses of
then daily. Monitor the pain scores interfere nonprescription analgesics
level of pain based on with sleep, daily may require further
a scale of 0–10 where activities and mood. assessment and/or
0 is no pain and 10 is treatment.
the worst possible Opioid analgesics will be
pain. required if burn is more
Assess whether pain severe.
interferes with sleep
or usual activities.
Burn healing Monitor daily for 2–3 Sunburn erythema Patients require further
days, then weekly should be markedly assessment and/or
until healing is reduced by 48 h. treatment if healing is not
complete (usually 2 Peeling is normal. In complete within 7 days or
wk). Monitor every 4– partial-thickness if there is a significant risk
6 wk to assess scar burns, when healing is or sign of scarring.
formation. complete, the wound
appears pink or red
with tiny opalescent
islands of epithelium
throughout and no
secretions.
Itching Monitor every 4–6 h Itching does not If itching does not respond
for itching on a daily interfere with sleep or to oral diphenhydramine or
basis for 5–7 days. normal activities. appears to worsen despite
Consider oral treatment, patient requires
antihistamines for further assessment and/or
itching not treatment.
responding to
supportive measures
such as moisturizing
lotions, cool
compresses or
bathing.
Infection Monitor daily at each No signs or symptoms If signs and symptoms of

(swelling; dressing change for of infection noted infection are observed at
surrounding signs of infection. before healing is the burn site, patient
redness that is complete. requires further
tender to touch; Risk is low after this assessment and/or
red streaks from point. treatment.
the wound; pus;
fever; swollen or
tender lumps in
the groin or
armpit)
Algorithms
Figure 1: Assessment of Patients with Burns

Suggested Readings
Health Canada. Clinical Practice Guidelines for Nurses in Primary Care. Adult care—Chapter 9—Skin.
Dermatological emergencies. Skin wounds. Available from: www.hc-sc.gc.ca/fniah-spnia/services/nurs-
infirm/clini/adult/skin-peau-eng.php.
References
1. Clayton MC, Solem LD. No ice, no butter. Advice on management of burns for primary care
physicians. Postgrad Med 1995;97:151-5,159-60,165.
2. Morgan ED, Bledsoe SC, Barker J. Ambulatory management of burns. Am Fam Physician
2000;62:2015-26, 2029-30, 2032.
3. Enoch S, Roshan A, Shah M. Emergency and early management of burns and scalds. BMJ
2009;338:b1037.
4. NSW Ministry of Health; Agency for Clinical Innovation. Connolly S. Clinical practice guidelines: burn
patient management. Chatswood: ACI; 2011. Available from:
www.aci.health.nsw.gov.au/__data/assets/pdf_file/0019/162631/Clinical_Practice_Guidelines_2012.pdf.
Accessed March 8, 2016.
5. Health Canada. Clinical Practice Guidelines for Nurses in Primary Care. Adult care—Chapter 9—Skin.
Dermatological emergencies. Skin wounds. Available from: www.hc-sc.gc.ca/fniah-
spnia/services/nurs-infirm/clini/adult/skin-peau-eng.php. Accessed March 8, 2016.
Dandruff and Seborrheic Dermatitis

Pathophysiology
Dandruff and seborrheic dermatitis are papulosquamous cutaneous disorders, which are the most commonly encountered group of skin
problems. They are characterized by palpable, usually erythematous, eruptions that typically all have a variable degree of scaling.1 They may
be difficult to distinguish from one another.
Seborrheic dermatitis and dandruff (pityriasis simplex capitis) are manifestations of different severities of a similar origin. Both cause
scaling on the scalp often associated with itching. Dandruff is a noninflammatory form with increased desquamation. Seborrheic dermatitis
is an inflammatory erythematous and scaling eruption primarily in “seborrheic areas”, those with high numbers of sebaceous glands—scalp,
face and upper trunk.
Uncommon in childhood, dandruff usually begins between ages 10 and 20 years, and affects up to 40% of men and women over age 30.2 It
is primarily a cosmetic problem. Turnover rate of skin cells may be twice the normal rate. It is associated with a dry environment but
Malassezia yeast may be present in some cases and play an inflammatory role. Although a relatively stable condition, it may be exacerbated
by poor hygiene or a dry winter environment.
Seborrheic dermatitis is found in about 3% of the population, affecting persons of all ages.2 Both infantile and adult forms exist. Flares
occur when sebaceous glands are most active (first 3 months of life and after puberty). The adult form, which is chronic, usually occurs
between 30 and 50 years of age. A male predominance is seen at all ages, regardless of race, probably because androgens control
sebaceous gland activity. In adolescents and adults, it is commonly manifested as “dandruff” or as an erythema of the nasolabial folds,
ranging in intensity from barely perceptible to marked, waxing and waning from the teens throughout adulthood.3 It may be a cutaneous
marker of HIV and AIDS, especially when severe, atypical or therapy-resistant. The incidence in patients with HIV may be as high as 85%.4
Despite its frequency, considerable controversy exists regarding the pathogenesis of seborrheic dermatitis. Some postulate that it is a
fungal disease caused by the lipophilic Malassezia yeasts, based on the observation of their presence in affected skin and the therapeutic
response to antifungal agents. Others propose that Malassezia infection is secondary to a primary inflammatory dermatosis that results in
increased cell turnover, scaling and inflammation in the epidermis (similar to psoriasis). It also has been traditionally considered to be a
form of dermatitis because Malassezia is present in healthy skin, the pathogenic mycelial form of Malassezia yeasts is absent, and it has a
chronic course. In addition, the lipase activity of Malassezia produces free fatty acids and reactive oxygen radicals which have antibacterial
activity that alters the normal skin flora, contributing to dermatitis. As a result of these theories, proposed treatments vary, ranging from
topical antifungals and antimicrobial peptides to topical corticosteroids and calcineurin inhibitors.5
Other factors contribute to the uncertainty around the etiology of seborrheic dermatitis. Though sebaceous glands are more active at the
times of life that seborrheic dermatitis presents (neonatal and postpubertal periods), there is no direct relationship between the amount or
composition of sebum and the condition.6 Hormonal factors have also been implicated. The occurrence of seborrheic dermatitis in the
neonatal period and remission by 6–12 months suggests a response to maternal androgen stimulation; recurrence postpuberty is further
evidence of a response to androgen stimulation.4 Atmospheric humidity and stress play a role as triggers.
Goals of Therapy
Dandruff:
Reduce or eliminate scales (dry flakes of skin) and flaking

Prevent recurrence by improving scalp hygiene
Eliminate or reduce environmental triggers
Seborrheic dermatitis:
Control not cure

Reduce fungus and the resulting scaling and inflammation
Relieve symptoms such as pruritus
Educate on the importance of control through good hygiene
Eliminate or reduce environmental triggers
Patient Assessment
A systematic approach to the assessment of dandruff and seborrheic dermatitis consists of assessing a patient's signs, symptoms and
history for the following:
Onset, frequency and duration of symptoms

Area and extent of involvement
Associated systemic symptoms
Aggravating factors
Description of skin lesions
Attempted treatments
Ensure further assessment if the diagnosis is in doubt, if there is sudden onset in a young patient in which HIV is suspected or if the patient
is not responding to treatment. Patients should also be appropriately assessed if the condition is widespread or generalized.4
Symptoms of Dandruff and Seborrheic Dermatitis
Lesions of seborrheic dermatitis and dandruff are often asymptomatic with a mild clinical course. Variations in the intensity of episodes
are common and may be precipitated by tiredness, stress or cold weather. In seborrheic dermatitis, pruritus varies, being common in
scalp and ear canal involvement, and may be intense. Dandruff is usually asymptomatic, although itching may develop.
Signs of Dandruff
Dandruff results in increased shedding of small flakes of scale from an otherwise normal scalp showing minimal erythema with no or
limited inflammation. The scales are silver-grey, in patches or diffuse, and may separate fully or become detached only after combing. It
is usually symmetrical, and absent in the bald area of male pattern baldness. There is no evidence of other skin disease on the scalp or
elsewhere.2,7,8 Dandruff does not present with scalp erythema. The characteristic scales are easy to diagnose yet often confused with
other scaling conditions of the scalp such as seborrheic dermatitis, tinea capitis and psoriasis.2
Signs of Seborrheic Dermatitis
Seborrheic dermatitis is an inflammatory, erythematous, greasy, scaling eruption often confused with dandruff (see photo, Seborrheic
Dermatitis). It is characterized by sharply demarcated yellow to brown, greasy or bran-like scaling patches and plaques. In adolescents
and adults, seborrheic dermatitis typically affects symmetric areas of the skin rich in sebaceous glands, including hairy areas of the
head, such as scalp, scalp margin, eyebrows, eyelashes, mustache and beard. Other common sites are the forehead, nasolabial folds,
external ear canals and postauricular creases. Seborrheic dermatitis of the trunk may appear in the presternal area and in infants, in
body folds, including the axillae, navel, groin, inframammary and anogenital areas.4
Photo 1: Seborrheic Dermatitis
iStockphoto
Seborrheic dermatitis typically presents as mild, greasy scales on the scalp that may be thick and may accumulate, with erythematous
plaques and scaling of the nasolabial folds, behind the ears and elsewhere. The borders of erythema and scaling may be seen at or
beyond the frontal hairline. It begins in small patches, rapidly spreading, with diffuse fine scales that can be white, off-white or yellow,
with no signs of acute dermatitis, such as oozing or weeping.9 Exudation may be seen in facial seborrheic dermatitis from time to time.
It typically flares and resolves in a cyclic or seasonal fashion, often in response to stress.1
Profuse powdery scales of the eyebrows may compromise wearing of contact lenses. The eyelids alone may be affected, developing
honey-coloured crusting called marginal blepharitis. There is erythema and scaling of eyelid margins and cilia, often associated with
mild granular conjunctivitis or ocular irritation. Involvement in other sites may not be present. Marginal blepharitis may also be
associated with ocular rosacea.
Paranasal involvement is typically seen in young women, who may not have dandruff. The most common type of facial seborrheic
dermatitis in males is a follicular erythematous form involving the upper lip, beard, scalp, back, flanks and abdomen. Plaques may
present with thick, adherent silvery scales (as seen with psoriasis) which usually spare the face, called sebopsoriasis.1 Ear involvement
may complicate otitis externa. On the trunk, 2 forms may appear—follicular (more common) or macular (rare).
In infants, the entire scalp may be covered with thick, dry, adherent, yellowish-brown scales overlying erythema, often called “cradle cap”.
It may also involve the central face, forehead and ears. A widespread erythema with cheesy exudate sometimes presents in the flexural
folds, manifesting as diaper dermatitis in infants or an intertriginous genital eruption in adults. These may generalize.9 Cradle cap is self-
limiting, appears in the first to fourth week and usually disappears after the first 3 months of life.
In both children and adults, persistent generalized seborrheic dermatitis may be associated with HIV infection. There is a predominance
of inflammatory and hyperkeratotic lesions, with involvement of trunk, groin and extremities, and occasionally erythroderma, alopecia
and hyper- or hypopigmentation.9
In chronic cases, nonscarring alopecia may occur secondary to inflammation and scratching. This alopecia should be reversible with
treatment.6
Failure to respond to therapy may indicate coexisting diseases such as fungal infections, psoriasis or HIV infection.
Scalp seborrheic dermatitis must be distinguished from atopic dermatitis, tinea capitis and psoriasis. Atopic dermatitis in adults tends
to affect the antecubital (inner elbow) and popliteal (behind the knee) fossae. In infants, atopic dermatitis has the same sites of
predilection as seborrheic dermatitis: face, diaper areas and extensor limbs. Seborrheic dermatitis may present with axillary
involvement, lack of scratching and absence of oozing and weeping. The distinction between seborrheic dermatitis and psoriasis may
be clarified by psoriasiform lesions elsewhere on the body or pitting of the nails. Facial seborrheic dermatitis can be confused with
rosacea, which displays central facial erythema, or forehead only, or with systemic lupus erythematosus which exhibits a butterfly-like
rash. Seborrheic dermatitis of the groin may resemble dermatophytosis, psoriasis and candidiasis, but tends to be bilaterally symmetric,
with reddish-brown patches that respond quickly to therapy. A very rare condition confused with seborrheic dermatitis in infants is
histiocytosis X, associated with systemic signs such as fever.9
Seborrheic Dermatitis: Risk and Aggravating Factors
Incidence of extensive and severe seborrheic dermatitis is significantly increased (30–83%) in HIV-positive patients and patients with
AIDS. They are more prone to an atypical explosive onset of seborrheic dermatitis, with more severe and generalized involvement.
Patients with CNS disorders (e.g., Parkinson's disease, cranial nerve palsies, major truncal paralyses) also appear to be prone to the
development of seborrheic dermatitis, tend to develop more extensive disease and are frequently refractory to treatment. Sebum
excretion may be increased secondary to either overactivity of the parasympathetic nervous system or action of androgens or
melanocyte-stimulating hormone.6
Other diseases associated with seborrheic dermatitis include depression, mood disorders and pityriasis versicolor.6
Areas of increased skin temperature on facial skin are sites predisposed to seborrheic dermatitis.6
Genetics, as well as other comorbid diseases, may predispose specific populations to seborrheic dermatitis, and an increased incidence
of allergy within the family is usually present.6
Environmental factors such as low humidity and temperature, as well as stress, may provoke flares of seborrheic dermatitis.1 Bright light
suppresses melatonin while UVA and UVB light inhibit the growth of Malassezia restricta; many patients report improvement in
seborrheic dermatitis during the summer.10
Drug-induced Seborrheic Dermatitis
A number of drugs have been implicated in causing or aggravating seborrheic dermatitis (see Table 1). When deciding whether to
discontinue the offending agent, consider individual circumstances such as the severity of the seborrheic dermatitis, the need for the
drug, and the availability of alternative medications.
11,12,13,14
Table 1: Drugs Known to Trigger Seborrheic Dermatitis
Arsenic Danazol Lithium Stanozolola
Auranofin Ethionamide Methyldopa Thiothixene
Aurothioglucose Gold Methoxsalena Trioxsalena
Buspirone Griseofulvina Penicillamine
Chlorpromazine Haloperidol Phenothiazines
Cimetidine Interferon, alfa Psoralens
a This medication is not currently marketed in Canada.
A summary of differential diagnosis and management of dandruff and seborrheic dermatitis is provided in Table 2.
Table 2: Characteristics, Differential Diagnosis and Management of Dandruff and Seborrheic Dermatitis
Condition Form Characteristics Differential Diagnosis Action
Dandruff Scalp Dry, white scales Seborrheic dermatitis Self-care management.

scattered diffusely over Psoriasis; see Psoriasis
scalp
Atopic dermatitis; see
Atopic, Contact, and
Stasis Dermatitis
Tinea capitis; see Fungal
Skin Infections
Seborrheic Scalp Greasy, yellowish scales Dandruff Self-care management.

Dermatitis over erythematous Psoriasis; see Psoriasis Requires further
patches assessement by
Atopic dermatitis; see
Atopic, Contact, and appropriate healthcare
Stasis Dermatitis practitioner if moderate
to severe.
Tinea capitis; see Fungal
Skin Infections
Facial Greasy, yellowish scales Atopic dermatitis Requires further

over erythematous (infants); see Atopic, assessement by
patches, involvement of Contact, and Stasis appropriate healthcare
nasolabial folds, Dermatitis practitioner.
eyebrows, eyelashes, Rosacea; see Acne
lips, retroauricular areas
Systemic lupus
erythematosus
Contact dermatitis; see
Atopic, Contact, and
Stasis Dermatitis
Groin Bilaterally symmetric, Atopic dermatitis Requires further

with reddish-brown fine (infants); see Atopic, assessement by
scaling patches Contact, and Stasis appropriate healthcare
Dermatitis practitioner.
Dermatophytosis; see
Fungal Skin Infections
Psoriasis; see Psoriasis
Candidiasis; see Fungal
Skin Infections
Dandruff and seborrheic dermatitis are often confused with psoriasis, especially when present on the scalp. Table 3 clarifies the
differences among the 3 conditions.
Table 3: Comparative Features of Dandruff, Seborrheic Dermatitis and Psoriasis

Feature Dandruff Seborrheic Dermatitis Psoriasis
Lesions On nonerythematous base Erythema with mild greasy yellow Annular well-demarcated silvery,
with fine, diffuse scales scales, plaques with indistinct scaly plaques, with erythematous
margins base; bleed easily
Common sites Scalp Central face, scalp, mid-chest Scalp, elbows, knees, sacrum
Palms and soles No No Common
Nails No No Pitting, thickening, dystrophy
Hair and scalp Yes Yes; hair may thin Thick scales common
Intertrigo (skin fold No Inverse type, glans penis, mostly Common

involvement) infants
Pruritus Due to dryness Varies; more common with Sometimes

involvement of scalp or ear canal
Feature Dandruff Seborrheic Dermatitis Psoriasis
Associated None May generalize in infants; worse in May generalize; psoriatic arthritis
systemic patients with HIV infection
symptoms
Infantile seborrheic dermatitis (cradle cap) is self-limiting and a conservative approach should be taken. A mild, nonmedicated shampoo
should be used initially for frequent washing. Scales may be softened with a surfactant-containing bath oil, gently brushed free with a baby
brush and washed clear. In scale removal, it is important to avoid irritation with strong shampoos or mechanical measures. Cradle cap
responds well to the use of emollients and moisturizers. One study showed that a nonmedicated topical cream or placebo cream applied
twice daily for up to 14 days were equally effective in reducing erythema crusting, scaling and oiliness.15 Infants do not respond to dietary
avoidance or vitamin supplementation.
Eyelids affected with seborrheic blepharitis can be treated with warm to hot compresses and washing with baby shampoo, followed by
gentle cotton tip debridement of thick scales.
Patients may also cut their hair shorter or trim their beards to decrease symptoms.16
Dandruff may improve in a moist environment. Stop use of hair sprays and pomades. Encourage use of a cool air humidifier.
For adult seborrheic dermatitis, the first steps are to discontinue aggravating factors and control stress. Seborrheic dermatitis often
improves in the summer months and in sunlight.16 Irritating soaps, heavy gels, hairsprays and greasy creams should be avoided. Excessive
hot water may dry out the skin. Dry air can provoke symptoms; placing a cool air humidifier or dish of water in the room adds moisture to
the environment.17
Nonmedicated shampoos: The main measure to remove scales and ease itching in dandruff or seborrheic dermatitis is frequent cleansing
with a nonmedicated, nonresidue shampoo (preferably one indicated for dry hair) and rinsing thoroughly to remove dirt, oil and scales.
Frequent shampooing is key to controlling symptoms while contributing to the cosmetic appearance of hair. Patients should use a
nonmedicated shampoo at least 3 times weekly. Even more frequent shampooing or a longer period of lathering may also be helpful in the
case of dandruff. Shampoos with surfactants (e.g., sodium lauryl sulfate) and detergents are better able to remove unsightly scales and will
lead to clinical improvement and decreased scaling.18 Frequency of shampooing can be decreased or increased according to response.
Once-weekly shampooing may be more reasonable for institutionalized patients.4 Patients who develop itching may decrease shampooing
due to the drying effects. Decreased frequency of shampooing can lead to further scale accumulation. The shampoo vehicle is important
for both nonmedicated cleansing products and medicated shampoos. The effect of the vehicle on appearance of the hair affects adherence
in the treatment of dandruff or seborrheic dermatitis.19
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Skin Care Products:
Acne, Dandruff and Seborrheic Dermatitis, and Dermatitis and Dry Skin.
General Use of Medicated Shampoos
To ensure adherence, the shampoo has to be both highly effective and cosmetically appealing. Effective therapies are based on
antifungal action, with associated anti-inflammatory and keratolytic action. Antiseptic activity is less important.7 Various regimens are
recommended (see Table 5).
Shampoos may be used on the scalp, beard and chest but may flare the disease if used on the face or other intertrigious areas if left on
for extended periods. To be effective, the shampoo must be massaged into the scalp for 4–5 minutes, rinsed thoroughly and repeated.
Instruct patients to part their hair in small sections, and apply and massage the medicated shampoo or scalp treatment into the scalp at
the hair roots. This should be repeated until the entire scalp has been treated. Medicated therapies should be left in contact with the
scalp or beard for 2–20 minutes depending on the product. For more severe cases, therapies can be left on overnight under a shower
cap, to allow the treatment to interact with the skin of the scalp. Moisturizing, nonmedicated shampoos or conditioners can be used
afterward to prevent desiccation of the hair.4
If the scalp is covered with diffuse, dense scales, the scales may be removed prior to using a medicated shampoo by applying warm oil
(mineral or olive), or a more easily rinsed surfactant-containing bath oil, to the scalp for several hours or overnight and then rinsing.4
Antifungals
Antifungal agents that decrease colonization by lipophilic yeasts (Malassezia species) are effective in the treatment of dandruff and
seborrheic dermatitis and are generally considered first-line therapy in both conditions. Seborrheic dermatitis in adults tends to be
chronic and recurrent. Treatment is directed toward control rather than cure. Seborrheic dermatitis tends to relapse after 2–3 weeks if
treatments are not carried out repetitively. This reflects the slow proliferation rate of Malassezia. Shampoos are used if scalp is affected
and creams or lotions for face, ears and trunk. Treatment effect of antifungals on overall quality of life remains unknown. Better study
design, outcome measures, and reporting are needed to improve the evidence base for antifungal treatment of seborrheic dermatitis.20
Topical ketoconazole is the most widely studied azole against Malassezia; however, other azoles have been used with success.21 Very
few studies of antifungals have assessed symptom clearance for longer than 4 weeks. At therapeutic concentrations, ketoconazole is
fungistatic.22 As a cytostatic, it also slows cell turnover.16 Approximately 80% of patients show good response within 4 weeks. Topical
ketoconazole causes fewer side effects than topical corticosteroid treatment.20 Long-term safety is favourable with chronic use and
efficacy is maintained.
Ciclopirox olamine has demonstrated similar efficacy to ketoconazole and can be used as an alternative treatment.20,23 Various
concentrations of ciclopirox olamine shampoo or gel are effective (1% is optimal) and safe in the treatment of seborrheic dermatitis of
the scalp, alone or in combination with zinc pyrithione.24,25,26,27
Selenium sulfide is fungicidal against numerous strains of Malassezia28 and may have fungistatic action on the scalp.3 It is classified as
a keratolytic by the FDA and slows scale production and epidermal proliferation. Although the use of selenium sulfide 2.5% suspension
in seborrheic dermatitis of the scalp has improved dandruff, folliculitis, pain and dryness, symptoms recur in more than 50% of patients
after stopping treatment.29 It should be used no more than twice weekly, as excessive use could cause oily hair and hair loss.3 It is more
effective with longer contact time. Mild cases of scalp seborrheic dermatitis may be controlled with selenium sulfide alone. It is also
used in combination with other topical therapy.
Zinc pyrithione has a somewhat similar mechanism of action to selenium sulfide. It has cytostatic properties and is classified as
keratolytic, but it also affects membrane transport, macromolecular synthesis, cell structure and function.30 It reduces counts of
Malassezia.3,7 Weekly shampooing with zinc pyrithione 1% significantly reduced dandruff in one study, but resolution of symptoms was
not complete after 9 treatments.7 Response rates may decrease over time, but this is due to nonadherence rather than tachyphylaxis.31
Zinc pyrithione shampoo significantly returned stratum corneum ultrastructure to normal, suggesting it can control dandruff.32 Like
selenium sulfide, it is more effective with longer contact time and may be effective alone for mild cases of scalp seborrheic dermatitis,
but is also used in combination with other topical therapy.
Propylene glycol 15% solution applied to the scalp reduces the numbers of yeast and, as a result of its hygroscopic effects, improves
seborrheic dermatitis in 90% of treated patients. It is commercially available or can be compounded.33
Many other topical antifungals have been used with varying success. These include clotrimazole, fluconazole, miconazole and
itraconazole.20
Oral antifungals are reserved for severe or refractory cases due to increased risk of side effects and drug interactions. Various
medications have been studied including fluconazole, itraconazole, ketoconazole and terbinafine. Ketoconazole therapy was associated
with more relapses compared with other treatments in one systematic review.34 Pulsed dosing of itraconazole (200 mg/day for 2
consecutive days/month) showed significantly higher efficacy and lower recurrence rates over 4 months compared with placebo in
patients with moderate to severe seborrheic dermatitis.35 Other evidence is generally of low quality and reported clinical efficacy varies
considerably among studies.
Anti-inflammatory Agents
Topical corticosteroids area also effective for decreasing the symptoms of seborrheic dermatitis36 and dandruff as they reduce pruritus
and inflammation. They may be added to antifungal treatment if the response is not adequate or the lesions are extensive or severe.
Topical corticosteroids are intended for temporary use. They should be discontinued when itching and erythema resolve, and
maintenance therapy with antifungals should then be adequate.4 Low-potency corticosteroids such as hydrocortisone 1% should be
used on the face or folds. Stronger topical corticosteroids may be used on other body areas if the response to hydrocortisone is
insufficient. Severe and thick scales on the scalp can respond to overnight application of topical corticosteroids followed by shower cap
occlusion. Long-term use of potent agents is discouraged for controlling seborrheic dermatitis as relapse rates are often high37 and
their use may lead to undesirable side effects such as atrophy, telangiectasia, poor wound healing, perioral dermatitis and pustular acne.
The form of topical corticosteroid selected is determined by the patient and the treatment site. Ointments, due to their occlusive nature,
are preferred for use on areas that are resistant to absorption or are dry or scaly. Avoid ointments if acne is present. Creams are used in
moist areas due to their drying effect, while lotions and solutions are best for the scalp and hairy areas or for large areas that require a
minimal application. The potency of the same corticosteroid is affected by the vehicle: ointment>cream>lotion.4 For more information
on the effect of vehicles, see Atopic, Contact, and Stasis Dermatitis and Psoriasis. In severe cases, keratolytics such as salicylic acid or
coal tar preparations may be used to remove dense scales, before applying topical corticosteroids.
Ocular corticosteroids should be avoided in seborrheic blepharitis.
Topical calcineurin inhibitors are immunomodulators used in the treatment of seborrheic dermatitis as second-line agents. Tacrolimus
and pimecrolimus have anti-inflammatory activity and tacrolimus has also demonstrated antifungal properties. These agents have
efficacy comparable to standard antifungal and topical corticosteroid treatments in decreasing severity of erythema, scaling and
pruritus.38 Tacrolimus ointment and pimecrolimus cream lack the side effects associated with corticosteroid use and require
significantly fewer applications to achieve comparable clinical response in adults with facial seborrheic dermatitis.39 They have also
been used in combination with topical corticosteroids.40,41,42,43 There is some evidence that intermittent (e.g., twice-weekly) use may
maintain remission in facial seborrheic dermatitis.44 Topical tacrolimus used together with zinc pyrithione may be an alternative to
topical corticosteroids in treating scalp seborrheic dermatitis.45 Concerns of a link between use of topical calcineurin inhibitors and
malignancy have not been substantiated by available evidence.35
Topical tacrolimus ointment and pimecrolimus cream are alternatives to topical corticosteroids in the treatment of seborrheic
blepharitis. Use of topical calcineurin inhibitors on the eyelids has an established long-term safety profile. Tacrolimus ointment is
reportedly more effective and better tolerated than pimecrolimus cream. Additional studies are needed to address the efficacy of
calcineurin inhibitors compared with topical corticosteroids.46
Keratolytic Agents
Traditionally, keratolytics have been used for dandruff and seborrheic dermatitis. Current mainstays of therapy are antifungals for
dandruff and antifungals plus anti-inflammatories for seborrheic dermatitis; however, keratolytics may be added on to other topical
therapy if the response has been inadequate. Their keratolytic effect may also increase penetration of other topical medications and
lead to increased effectiveness.
Salicylic acid and sulfur have minimal proven antifungal activity but are mildly effective because of their keratolytic and antiseptic
activities. They are used alone or combined with other active ingredients. Salicylic acid provides a keratolytic effect by loosening the
bonds between keratinocytes in the skin, which helps detach flakes and increases the penetration of other drugs.1,7 Sulfur exhibits
antifungal, antibacterial and keratolytic activity.32 Products containing salicylic acid and sulfur are more potent, but are proportionally
more irritating and therefore proper use is important.3 Bar, cleansing lotion and shampoo forms include salicylic acid 2–3% and sulfur
3–5%. All products should be lathered into the scalp with continued rubbing for at least 5 minutes, and then rinsed thoroughly. Young
children may be at more risk of unwanted side effects because of increased absorption of salicylic acid through the skin. Salicylic acid
should not be applied to large areas of the body or used for long periods of time in this population.18 Discontinue other drying
preparations such as cosmetics, soaps or alcohol-containing products. Generally, products containing salicylic acid and sulfur should be
used no more than twice a week.
Coal tar is mildly effective for seborrheic dermatitis because it reduces local swelling and inflammation, relieves itching and is
keratolytic and antiseptic. However, it has minimal antifungal activity, making it a poor alternative to anti-Malassezia agents.7 Coal tar
reduces cell proliferation and requires time to lengthen cell differentiation and normalize epidermal differentiation, resulting in a slow
decline in visible scales. It is available in shampoo, ointment, lotion, gel and bath forms that are used once daily to once weekly on the
beard, face, body or scalp. Avoid the eye area to prevent irritation and apply a sunblock when outdoors. Irritation generally subsides
following discontinuation or when the frequency of use is reduced. Coal tar preparations may also contain alcohol that will cause
burning and irritation of acutely inflamed skin. Coal tar products are messy, can stain blond or grey hair and clothing, have an unpleasant
odour and can possibly cause tar acne, contact dermatitis18 and photosensitivity.17
Other Treatments
Many other alternative treatments have been used for severe or refractory cases or as novel approaches. Some of these are noted
below.
Topical metronidazole has been studied vs. placebo or antifungals with mixed results.47,48,49,50
Sodium sulfacetamide 10% lotion alone or in combination with a topical corticosteroid has been used in the treatment of seborrheic
dermatitis, including seborrheic blepharitis. There are no comparative trials for the use of this agent.8
Limited low-quality evidence has shown lithium gluconate 8% ointment to be more effective than ketoconazole 2% emulsion for
inducing complete remission in seborrheic dermatitis, with comparable safety. Lithium also showed better results on symptoms of
burning and dryness. Systemic absorption of topical lithium is low.36,51,52 This product is not commercially available in Canada but can
be compounded. It should be considered a last resort for recalcitrant cases.
Ultraviolet light inhibits Malassezia yeasts. Many patients note improvement during the summer months. UVB phototherapy has been
shown to be effective in severe seborrheic dermatitis.53,54 However, some patients have developed seborrheic dermatitis subsequent to
psoralens UVA (PUVA) therapy.6,55 Phototherapy may be ineffective if patients have thick hair.
Other therapies such as nicotinamide 4% cream,56 a shampoo containing lipohydroxy acid and salicylic acid57 and a solution containing
urea, lactic acid and propylene glycol58 have shown some efficacy in small preliminary studies.
Comparative Efficacy
Most studies are small and short (4 weeks or less), not appropriately blinded and do not compare more than 1 or 2 ingredients or use
controls. They also may restrict area of application to face and scalp or body alone. Outcomes are not similar and do not examine
Malassezia action as well as short- and long-term clearance. Lack of strong evidence affects recommendations for comparative
efficacy. Adequate trials should be more than 200–300 participants; follow-up time should be at least 1 year, and outcomes should be
well validated in terms of areas of application.20,36 Overall, antifungals (particularly ketoconazole and ciclopirox olamine) produce better
or equal clinical responses in the treatment of seborrheic dermatitis in the short term compared with other agents and have a specific
action against Malassezia. From highest to lowest, efficacy of these compounds can be ranked as: 1) antifungals or moderate-potency
corticosteroids; 2) hydrocortisone or calcineurin inhibitors; 3) selenium sulfide; 4) zinc pyrithione; 5) keratolytics; and 6) coal tar.7
Antifungals can be used long term without decreased response whereas topical corticosteroids must be used intermittently in
combination with other agents. Calcineurin inhibitors, as second-line agents, can also be used intermittently in combination with other
agents for maintenance.
Figure 1 provides a suggested approach for the treatment of dandruff and seborrheic dermatitis of the scalp. Figure 2 provides a
suggested approach for the treatment of nonscalp seborrheic dermatitis. See Table 5 for information on therapies for dandruff and
seborrheic dermatitis.
Evidence showing that natural health products and homeopathic products are efficacious is limited. Further, the use of herbal
preparations that are nonstandardized should be discouraged in favour of traditional quality-controlled preparations.59
Quassia amara gel 4% has been compared with topical ketoconazole 2% and topical ciclopirox oalamine 1% for facial seborrheic
dermatitis with significant advantage in efficacy after 4 weeks.60
Heartsease (Viola tricolor) and oat straw (Avenae stramentum) are herbal formulations that are purported to be effective for mild cases
of seborrheic dermatitis. Viola tricolor is applied externally as a poultice or in an infusion to the area at a dose of 15 mL TID. Avenae
stramentum is administered in a bath soak (100 g).
Tea tree oil (Melaleuca alternifolia) leaves contain terpinen-4-ol, which has some in vitro activity against M. furfur. Solutions of 5–10% are
used as external antifungals.61 Tea tree oil 5% was effective and well tolerated in the treatment of dandruff compared with placebo.62
Leaf extract of the plant Solanum chrysotrichum possesses biologic activity against dermatophytes and yeast. Various steroidal
saponins with antimycotic activity have been isolated from the active extract. Therapeutic effectiveness and tolerability of the
standardized extract from S. chrysotrichum for local treatment of pityriasis capitis associated with the yeast Malassezia showed no
significant difference compared with ketoconazole 2%.63
Table 4 presents a monitoring framework for patients with dandruff and seborrheic dermatitis. The parameters should be monitored by the
patient in a diary. Scales will improve quite quickly with cosmetic treatment and hygiene control; thickness of scales will improve more
slowly and erythema will take longest to respond.
The side effects of drug therapy should also be monitored. Discontinue therapy if allergic reactions occur. If the condition worsens due to
irritation, alter therapy. Failure to meet the end points should result in alteration of dosage or drug therapy. Therapy should be appropriately
tapered in response to improvement or resolution.
Table 4: Monitoring of Therapy for Dandruff and Seborrheic Dermatitis

Parameter Timeframe/Degree of Actionsa
Change
Effectiveness endpoints (resolution/control; relief of symptoms)
Scales Decrease by 50% within 7– Taper therapy in response to resolution: if end points not achieved,
10 days consider additional or different therapy.
Thickness of plaque Decrease by 50% within 6–8

wk and by 75% within 8–12
wk
Redness Decrease by 50% within 8–

12 wk and by 75% within
12–16 wk
Surface area involved Decrease by 50% within 6–8

wk and by 75% within 8–12
wk
Extension to other sites or None

generalization
Itch/scratching Decrease to tolerable level

within 1–2 wk
Disruption of sleep or daily Restoration of normal

activities patterns within 2–3 wk
Stress, anxiety, depression Restoration of normal

patterns within 2–3 wk
Progression of severity No progression of severity
Recurrent episodes Lengthening of symptom-

free periods throughout
therapy
Safety endpoints (treatment side effects)
Allergic reactions None If they occur, discontinue therapy. If severe, decrease dose,
concentration or frequency of use. If still no improvement, consider
different therapy.
Severe dryness, irritation Minimal
(redness, inflammation, Should disappear, diminish
stinging) or be controlled with
continued use
a
Advise patients to monitor each parameter daily while on drug therapy. Healthcare practitioners should monitor each parameter after 2–3 wk or at the
next visit.
Algorithms
Figure 1: Treatment of Dandruff and Seborrheic Dermatitis of the Scalp
Figure 2: Treatment of Nonscalp Seborrheic Dermatitis
Drug Table
Table 5: Therapy for Dandruff and Seborrheic Dermatitis
Class Drug Dosage Onset Adverse Effects Comments Costa
Antifungals, ciclopirox Scalp: Requires 2–3 Uncommonly: Alternative to Cream/Lotion:$

topical olamine Shampoo: Use 2–3 times wk to see Pruritus, burning ketoconazole. Shampoo:$$
Loprox (cream, weekly or as often as onset of sensation. If using
lotion), Stieprox necessary effect and 4 antifungal in a
(shampoo) Application Instructions: wk to see full patient already
Wet hair and part a small effect. on
section. Rub into scalp at Maintain use corticosteroid
the roots. Repeat until at the treatment,
entire head has been interval maintain
treated. Leave on for at necessary to corticosteroid
least 5 min then rinse keep the for 2–3 wk to
condition allow time for
Body: under onset of effect
Cream, lotion: Rub gently control. of antifungal,
into affected area BID. then withdraw
Can be applied to beard, the
face and body corticosteroid
Prophylaxis/maintenance: (to prevent
Treat once every 1–2 wk rebound flare
of symptoms).
Antifungals, ketoconazole Scalp: Requires 2–3 <1% systemic First-line $

topical Ketoderm Shampoo: Use 2–4 times wk to see absorption. treatment.
(cream), Nizoral weekly onset of Minimal scalp Avoid eye area.
(shampoo) Application Instructions: effect and 4 and skin If using
Wet hair and part a small wk to see full irritation, itching, antifungal in a
section. Rub into scalp at effect. stinging. patient already
the roots. Repeat until Maintain use May cause on
entire head has been at the greasy or dry corticosteroid
treated. Leave on for at interval hair or scalp. treatment,
least 5 min then rinse necessary to Less irritating maintain
keep the than selenium corticosteroid
Body: condition sulfide. for 2–3 wk to
Cream: Rub gently into under allow time for
afffected area once daily. control. onset of effect
Can be applied to beard, of antifungal,
face and body then withdraw
Prophylaxis/maintenance: the
Treat once every 1–2 wk corticosteroid
(to prevent
rebound flare
of symptoms).
Antifungals, selenium sulfide Scalp: Requires 2–4 Excessive use Second-line $

topical Selsun, Selsun Shampoo 1%, Lotion wk to see may cause oily therapy.
Blue, others 2.5%: 2 applications per effect. hair and hair Cannot be used
wk for 2 wk and Maintain use loss. on damaged or
afterwards use at less at the Will sting if inflamed skin.
frequent intervals; do not interval applied to Avoid eye area.
use more than 3 times per necessary to broken skin.
wk keep the May discolour
Application Instructions: condition bleached, tinted
Wet hair and part a small under or permanent-
section. Rub into scalp at control. waved hair.
the roots. Repeat until Avoid use of
entire head has been these hair
treated. Leave on for at products within
least 5 min then rinse 2 days of
treatment with
selenium sulfide.
Avoid contact
with any jewelry
as it may be
damaged.
Antifungals, zinc pyrithione Scalp: Requires 2–4 May discolour Second-line $

topical Head and Shampoo: Use 2–3 times wk to see hair if metal- therapy.
Shoulders weekly or as often as effect. based tints are
Shampoo, Z- necessary Maintain use used.
Plus Shampoo, Application Instructions: at the Safe to use after
others Wet hair and part a small interval perm solutions.
section. Rub into scalp at necessary to
the roots. Repeat until keep the
entire head has been condition
treated. Leave on for at under
least 5 min then rinse control.
Calcineurin pimecrolimus Body: Requires 2–4 Mild and Second-line $70

inhibitors Elidel Rub a thin layer into wk to see transient skin therapy.
affected area BID effect. burning at onset
Maintenance dose: Once Maintain use of therapy.
daily, 2 days per week at the Lacks the long-
interval term side effects
necessary to of topical
keep the corticosteroids.
condition
under
control.
Calcineurin tacrolimus Body: Requires 2–4 Mild and Second-line $70

inhibitors Protopic Rub a thin layer into wk to see transient skin therapy.
affected area BID effect. burning at onset
Maintenance dose: Once Maintain use of therapy.
daily, 2 days per wk at the Lacks the long-
interval term side effects
necessary to of topical
keep the corticosteroids.
condition
under
control.
Corticosteroids, hydrocortisone Scalp or Body: Treat for 1–2 Well tolerated. Useful for $
topicalb Cortate, Emo- Rub gently into affected wk to see suppressing
Cort, Prevex HC, area BID–TID effect. initial
generics Reassess inflammation.
use after 2 Stronger
wk and topical
continue corticosteroids
intermittently may be used
if needed. on body areas
Alternate other than face
with and folds if the
emollients or response to
other agents hydrocortisone
for is insufficient.
maintenance
if necessary.
Corticosteroids, betamethasone Scalp: Treat for 1–2 Burning/irritation Moderate- $

topical valerate lotion Apply a thin film BID–TID wk to see at application potency topical
(formulated for Valisone Scalp to completely cover effect. site, pruritus, corticosteroid.
scalp)b Lotion, generics affected area Reassess dryness, atrophy. Severe and
use after 2 thick scales on
wk and the scalp can
continue respond to
intermittently overnight
if needed. application of
Alternate topical
with corticosteroids.
emollients or
other agents
for
maintenance
if necessary.
Corticosteroids, betamethasone Scalp: Treat for 1–2 Burning/irritation Moderate- $80

topical valerate foam Apply a thin film BID to wk to see at application potency topical
(formulated for Luxiq completely cover affected effect. site, pruritus, corticosteroid.
scalp)b area Reassess dryness, atrophy. Severe and
use after 2 thick scales on
wk and the scalp can
continue respond to
intermittently overnight
if needed. application of
Alternate topical
emollients or
other agents
for
maintenance
if necessary.
Corticosteroid, betamethasone Scalp: Treat for 1–2 Corticosteroid: Moderate- $$

topical/keratolytic valerate/salicylic Apply a thin film once wk to see burning, itching, potency topical
combination acid daily–BID effect. irritation, corticosteroid.
(formulated for Diprosalic, Reassess acneiform Severe and
scalp) generics use after 2 eruptions, skin thick scales on
wk and atrophy, striae. the scalp can
continue Keratolytic: respond to
intermittently erythema, overnight
if needed. scaling, local application of
Alternate irritation. topical
emollients or
other agents
for
maintenance
if necessary.
Keratolytic agents coal tar Scalp: Requires 2–4 Folliculitis Second-line $

Denorex, Liquor Once daily to once weekly wk to see (especially of treatment.
Carbonis as needed effect. hairy regions), Additive
Detergens, More effective with Follow by acne, contact antimitotic
Targel, others prolonged contact time interval dermatitis, activity with
necessary to photosensitivity, UVA and UVB.
keep the unappealing Products may
condition odour, stains contain crude
under skin and hair. coal tar or tar
control. distillates
(which are 10–
20% as potent
as crude coal
tar).
Also available
in commercial
products
combined with
salicylic acid
and/or sulfur.
Keratolytic agents salicylic acid Scalp: Requires 2–4 Irritation, Salicylic acid $
Dermarest, At least twice weekly, wk to see redness or enhances
Sebcur, others massaging thoroughly effect. peeling. penetration of
into affected area Follow by Irritating to topical agents
interval mucous through
necessary to membranes and stratum
keep the eyes. corneum.
condition Also available
under in commercial
control. products
combined with
coal tar and/or
sulfur.
Keratolytic agents sulfur Scalp: Requires 2–4 Irritation, Many $$

Sulfur8, others At least twice weekly, wk to see redness or commercial
massaging thoroughly effect. peeling. products
into affected area Follow by Irritating to contain various
interval mucous combinations
necessary to membranes and of coal tar,
keep the eyes. salicylic acid,
condition sulfur.
under
control.
a
Cost of 30 g for cream or smallest available pack size unless otherwise specified; includes drug cost only.
b For a comprehensive list of topical corticosteroids, see Corticosteroids: Topical (CPhA Monograph).
Legend: $ <$10 $$ $10–20
Suggested Readings
Johnson BA, Nunley JR. Treatment of seborrheic dermatitis. Am Fam Physician 2000;61:2703-10, 2713-4.
Kastarinen H, Oksanen T, Okokon EO et al. Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp. Cochrane
Naldi L, Rebora A. Clinical practice. Seborrheic dermatitis. N Engl J Med 2009;360:387-96.
Okokon EO1, Verbeek JH, Ruotsalainen JH et al. Topical antifungals for seborrhoeic dermatitis Cochrane Database Syst Rev
2015;5:CD008138.
References
1. Gardner SS, McKay M. Seborrhea, psoriasis and the papulosquamous dermatosis. Prim Care 1989;16:739-63.
2. Shuster S. The aetiology of dandruff and the mode of action of therapeutic agents. Br J Dermatol 1984;111:235-42.
3. Tooley P. Dandruff: an irritating problem. Practitioner 1990;234:593-6.
4. Johnson BA, Nunley JR. Treatment of seborrheic dermatitis. Am Fam Physician 2000;61:2703-10, 2713-4.
5. Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clin Dermatol
2013;31:343-51.
6. Wattanakrai P. Seborrheic dermatitis and dandruff. In: Arndt KA, Tsu JT. Manual of dermatologic therapeutics. 7th ed. Philadelphia:
Wolters Kluwer/Lippincott Williams & Wilkins; 2007. p. 29:180-4.
7. McGrath J, Murphy GM. The control of seborrhoeic dermatitis and dandruff by antipityrosporal drugs. Drugs 1991;41:178-84.
8. Sobell JM, Geist DE. Psoriasis. In: Arndt KA, Tsu JT. Manual of dermatologic therapeutics. 7th ed. Philadelphia: Wolters
Kluwer/Lippincott Williams & Wilkins; 2007. p. 27:164-73.
9. Janniger CK, Schwartz RA. Seborrheic dermatitis. Am Fam Physician 1995;52:149-55, 159-60.
10. Maietta G, Rongioletti R, Rebora A. Seborrheic dermatitis and daylight. Acta Derm Venereol 1991;71:538-9.
11. Zone J, Ward J, Boyce E et al. Penicillamine-induced pemphigus. JAMA 1982;247:2705-7.
12. Greenberg RD. Acne vulgaris associated with antigonadotropic (Danazol) therapy. Cutis 1979;24:431-3.
13. Litt JZ, Pawlak WA. Drug eruption reference manual. 4th ed. Cleveland: Wal-Zac Enterprises; 1995. p. 1-13.
14. Collins CD, Hivnor C. Seborrheic dermatitis. In: Goldsmith LA, Katz SI, Gilchrest BA et al. Fitzpatick’s dermatology in general medicine.
8th ed. New York: McGraw-Hill; 2012. p. 259-66.
15. David E, Tanuos H, Sullivan T et al. A double-blind, placebo-controlled pilot study to estimate the efficacy and tolerability of a
nonsteroidal cream for the treatment of cradle cap (seborrheic dermatitis). J Drugs Dermatolog 2013;12:448-52.
16. Pandya AG. Seborrheic dermatitis or tinea capitis: don't be fooled. Int J Dermatol 1998;37:827-8.
17. Arndt KA et al., eds. Primary care dermatology. Boston: Saunders; 1997.
18. Arndt KA. Manual of dermatologic therapeutics: with essentials of diagnosis. 5th ed. Boston: Little, Brown; 1995.
19. Draelos ZD, Kenneally DC, Hodges LT et al. A comparison of hair quality and cosmetic acceptance following the use of two anti-
dandruff shampoos. J Investig Dermatol Symp Proc 2005;10:201-4.
20. Okokon EO1, Verbeek JH, Ruotsalainen JH et al. Topical antifungals for seborrhoeic dermatitis. Cochrane Database Syst Rev
2015;5:CD008138.
21. Cauwenbergh G. International experience with ketoconazole shampoo in the treatment of seborrhoeic dermatitis and dandruff. In:
Shuster S, Blatchford N, eds. Seborrhoeic dermatitis and dandruff: a fungal disease. London: Royal Society of Medicine Services;
1988. p. 35-42.
22. Borgers M. Ultrastructural correlates of antimycotic treatment. Curr Top Med Mycol 1988;2:1-39.
23. Ratnavel RC, Squire RA, Boorman GC. Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%)
in the treatment of seborrhoeic dermatitis. J Dermatolog Treat 2007;18:88-96.
24. Altmeyer P, Hoffmann K. Efficacy of different concentrations of ciclopirox shampoo for the treatment of seborrheic dermatitis of the
scalp: results of a randomized, double-blind, vehicle-controlled trial. Int J Dermatol 2004:43:9-12.
25. Gupta AK, Nicol KA. Ciclopirox 1% shampoo for the treatment of seborrheic dermatitis. Int J Dermatol 2006;45:66-9.
Diaper Dermatitis

Pathophysiology
Diaper dermatitis (“diaper rash”) is a highly prevalent condition causing discomfort to patients, affecting caregivers and
frustrating healthcare practitioners.1 It is a form of area-specific contact dermatitis and can be irritant or allergic.
Irritant diaper dermatitis is the result of progressive barrier compromise, and in mild forms is characterized by dryness, scaling,
abnormal desquamation and erythema. In severe cases there are eruptions, papules, vesicles, intense erythema and
ulcerations. Reported frequencies vary depending on methodologies, but most are of an irritant etiology. Prevalence in infants
ranges from 25–53% varying with population, and up to 75% in diaper-wearing incontinent elderly nursing home patients.1
Seborrheic dermatitis is a predisposing factor for infants.2
Diaper dermatitis is the cumulative result of several features of the diaper environment which predispose the skin to damage,
especially overhydration and contact with skin irritants (including urine, feces, associated enzymes and bile salts). Other
factors play a role, including: mechanical friction (skin-to-diaper and skin-to-skin), increased skin pH (contributing to decreased
barrier function and increased reactivity to irritants), diet (fecal composition), age (urinary frequency), gestational age (inherent
barrier maturation), antibiotic therapy, diarrhea and underlying medical conditions. Risk is higher in infants who are diapered
with cotton diapers plus plastic covers, fed cow's milk (vs. breast milk), or malnourished.1
Diapers
Diapered-skin pH is higher due to effects of occlusion and increased skin permeability, leading to increased skin hydration
and risk of diaper rash.3 Controversy persists about whether cloth or disposable diapers better minimize diaper dermatitis,
because variables such as duration of wetness and frequency of diaper changes are not controlled in many studies.
Reusable cloth diapers may contribute to dermatitis if not adequately washed and rinsed of harsh cleansing chemicals.
Airtight plastic occlusion to prevent leakage of urine and stool increases the risk of excessive hydration and maceration of
skin; modern disposable diapers minimize this by wicking urine and water away from the skin surface to outer diaper layers.
Prolonged wearing of any diaper promotes damage to the skin.4
Friction and Contact Irritation
A primary causative factor is repeated friction as the infant or immobilized patient shifts in the bed or chair. Body folds
increase areas of skin-to-skin contact. More frictional injury occurs if the skin is wet, producing chafing and shiny erythema
and allowing other irritants to harm the skin.4
Urine and Ammonia
The level of ammonia in infant urine is not sufficient to cause or initiate diaper dermatitis but may aggravate an existing
inflammatory process.1 Damaged skin is more susceptible to irritating effects of ammonia, which is liberated by urease
enzymes from cutaneous or colonic bacteria.5 Urine hydrates the skin and makes it more vulnerable to frictional injury.4
Feces and Alkaline pH
The most important factors in the pathogenesis of diaper dermatitis are now considered to be the alkaline pH of the urine
and the role of fecal bacteria. Perineal skin breakdown can occur in infants and older patients when pancreatic enzymes
and bile salts cannot be adequately deactivated in the colon. The resultant lipases, proteolytic enzymes and ureases
present in the feces may induce contact irritant dermatitis by attacking the epidermis and raising the surface pH to alkaline
range. Fecal protease activity is pH dependent and increases to a maximum at pH 7.1 Ammonia also raises the pH of the
skin, making it more susceptible to damage or infection. An alkaline pH also facilitates the development of Candida
albicans. Loose and watery stools, common in infants, contribute to excessive hydration and frictional forces.4 Cow's milk–
fed infants are more likely to develop diaper dermatitis because these formulas are colonized by a greater number of
urease-producing bacteria.2 Breastfed infants, whose feces are less copious, less alkaline and less caustic, may have less
diaper rash. Foods ingested by either infants or breastfeeding mothers that increase the urinary and fecal pH (e.g., high-
protein diets) may contribute to diaper rash.
Microorganisms
Candida infection is associated with diaper wearing. This is partly due to the fact that moist environments support
microbial growth.1 More importantly, the GI tract is an important reservoir for C. albicans, a secondary invader of dermatitic
skin. Feces containing C. albicans are held against the skin, providing a mechanism for infection. C. albicans is present in
70–80% of patients with diaper dermatitis, compared with 10–12.5% in those without diaper dermatitis.4,6,7 Candida is
most frequently found in the periphery of intense diaper dermatitis, particularly in pustules.
Colonization of dermatitic skin by Staphylococcus aureus can occur frequently, and can be suspected in a severely inflamed
dermatitis with follicular pustules.
Goals of Therapy
Avoidance of causative factors
Relief of symptoms
Resolution of dermatitis
Prevention of complications and recurrences
Patient Assessment
Diaper dermatitis is a “geographic” diagnosis (strictly confined to the diaper area), occurring in patients of any age who
wear diapers. Onset of diaper dermatitis is gradual but may not be clinically apparent until an abrupt appearance of
observable skin changes in the few hours between diaper changes. The location of diaper rash is the area covered by the
specific boundaries of the diaper: around the lower abdomen and the lumbar back at about the level of the umbilicus and
below, around the upper thighs, encompassing the genitalia, perineum and buttocks.1 It may be more extensive on the front
or back if the diaper wearer lies primarily in one position.
Irritant Diaper Dermatitis
Irritant contact dermatitis or chafing rash is the most common type of primary diaper dermatitis. Clinically, diaper
dermatitis appears as moist, sometimes scaly and erythematous, often shiny patches over the convex surfaces of the
diaper area, including the buttocks, genitalia, lower abdomen and upper thighs. Irritant diaper dermatitis usually spares
the inguinal skin folds (creases). It may appear dusky purple on darker skin. The spectrum of severity ranges from mild,
with erythema, to severe, with a shiny, deep erythema, followed by the development of erythematous papules, vesicles
and oozing and widespread shallow erosions and ulcers.8 It can be asymptomatic or tender. It may resolve
spontaneously or wax and wane, but is treated regardless.
Candida Diaper Dermatitis
Candida diaper dermatitis is the second most common diaper dermatitis after irritant diaper dermatitis. Candida from
intestinal flora contaminates any type of diaper dermatitis present for greater than 3 days and the levels increase with
clinical severity of the dermatitis. The most common presentation is an initial diffuse erythematous patch progressing
over days to confluent tomato-red plaques, papules, pustules, peripheral scale and small erythematous satellite papules,
which are most likely to be culture-positive for Candida. It is classically described as a beefy red rash with satellite
pustules, with early maceration of the anal mucosa and perianal skin. It almost always involves the inguinal creases.
Pustules may not be seen due to maceration under the diaper.8,9 Oral thrush may also be present.
Allergic Diaper Dermatitis
An allergic reaction may resemble the irritant presentation but typically consists of grouped or linear tense vesicles and
blisters and, in severe involvement, marked edema, particularly in genital areas.
Irritants and friction: Chemical and mechanical irritants from urine, feces, cleansing products and cleansing methods
contribute to and aggravate diaper dermatitis. Excessive rubbing and over-cleaning can cause mechanical stripping and
barrier damage. Frequent vigorous cleansing with detergents or soaps can actually induce contact dermatitis and can
easily aggravate already inflamed, damaged skin.
Chemicals: Various ingredients in skin care products may aggravate or cause diaper dermatitis. See Chemical/Drug-
induced Diaper Dermatitis.
Comorbid Conditions: Infants with atopic or seborrheic dermatitis or psoriasis, the incontinent immobilized patient, and the
incontinent elderly are at greater risk of diaper dermatitis.10 Diaper dermatitis can also be a manifestation of other diseases
such as Kawasaki's syndrome, granuloma gluteale infantum and cytomegalovirus. Unusual manifestations of diaper
dermatitis may occur in infants born to immunocompromised mothers. Untreated or infected diaper dermatitis can
progress to skin ulceration, infection of the penis or vulva, and urinary tract infections.
A summary of the possible differential diagnoses related to diaper dermatitis is provided in Table 1.
Table 1: Differential Diagnosis of Diaper Dermatitis

Diagnosis Symptoms
Primary irritant diaper dermatitis Erythematous, often shiny, patches over the convex surfaces of the
diaper area, usually sparing the inguinal skin folds.
Candida diaper dermatitis Early maceration of the anal mucosa and perianal skin, progressing over
days to confluent tomato-red plaques, papules, pustules, peripheral scale
and satellite papules, almost always involving the inguinal creases. Lack
of sebum by age 4 months or oral antibiotic therapy for otitis media may
be factors. May have thrush in oral cavity.
Miliaria rubra (prickly heat, heat rash) Clear superficial vesicles without inflammation in newborns, or in older
infants, tiny red papules and papulovesicles, sometimes pruritic due to
eccrine sweat duct occlusion. Also found in overlapping skin folds in
infants, especially neck and axillary folds. May be caused by occlusion
from plastic outer coverings of diapers.
Allergic contact dermatitis (see More common in infants over 12 months. Failure to respond to treatment
Atopic, Contact, and Stasis for irritant dermatitis. Allergy to component of topical preparation. More
Dermatitis) severe in flexural areas since topical agent may concentrate in folds.
Seborrheic dermatitis (see Dandruff Well-circumscribed, erythematous, greasy scaly plaques with flexural
and Seborrheic Dermatitis) accentuation, typically asymptomatic. May involve scalp, neck, face,
axillae and retroauricular areas as well. Occurs in the first 6 months of
life and extremely common in the aged.
Atopic dermatitis (see Atopic, Usually not in the groin, but atopic individuals are more susceptible to
Contact, and Stasis Dermatitis) irritant dermatitis, which may present as acute dermatitis or chronic
lichenification. History of pruritus, eczema, especially in flexural areas,
asthma or allergic rhinitis. Later onset (after 2 months) and family history
of atopy.
Psoriasis (see Psoriasis) Less common. Brilliant erythematous plaques in the diaper area, lack of
silvery scale due to hydrating effect of diapers. Family history of
psoriasis and typical lesions elsewhere on the body. Lack of response to
topical steroids and antiyeast medications.
Scabies (see Parasitic Skin Infections: Excoriations and ill-defined papular eruptions in the diaper area. Burrows
Lice and Scabies) on palms, soles, axillary and genital areas, nipples, umbilicus and finger
webs. Itching persists 3–4 wk after treatment.
Bullous impetigo (see Bacterial Skin Large flaccid bullae filled with straw-coloured liquid in the first few weeks
Infections: Impetigo, Furuncles and of life. Ruptured bullae leave red, denuded areas and honey-coloured
Carbuncles) crusts.
Diagnosis Symptoms
Histiocytosis Rare. Recalcitrant diaper dermatitis with erythematous papules

surmounted by scale; may be hemorrhagic. Involvement of scalp and
retroauricular areas. Systemic symptoms of hepatosplenomegaly,
anemia and lymphadenopathy.
Acrodermatitis enteropathica Disorder of zinc metabolism leading to perioral, perineal and sacral skin
erosions and erythematous, well-demarcated scaly plaques. Infants may
also have alopecia, growth failure, diarrhea and irritability.
Congenital syphilis Copper-coloured erythematous macules and papules and moist erosions
in the diaper region, denuded sacral areas. May have anemia,
hepatosplenomegaly, jaundice, bone involvement.
Chemical/Drug-induced Diaper Dermatitis
The risk of chemical or drug-induced diaper dermatitis, which may be allergic or irritant contact dermatitis, is greater in
infants than in other patients due to the thin epidermis, high surface-to-volume ratio and differences in systemic
metabolism and detoxification in very young children, particularly those with inflamed skin. Elderly diapered patients with
atrophic skin are similarly more susceptible to injury from topical agents.5
Products containing boric acid are not recommended due to toxicity.11,12 Benzalkonium chloride is used in skin products as
a disinfectant or preservative and has been implicated in allergic dermatitis in infants; its use should be avoided.13 Volatile
alcohol (ethyl and isopropyl), fragrance and cleansing products containing surface active agents (surfactants) may
aggravate dermatitis. Surfactants vary in inherent irritancy as reported in Table 2. Residual surfactant can remain on the
skin when copious rinsing is not practical. There is a rising incidence of allergy, currently reported as 1.5–6%, to a common
preservative in baby wipes called methylisothiazolinone, due to increased use. Some associations have called for a ban on
its use.14
In addition to the topical medications listed in Table 3 which directly cause contact dermatitis, medications can contribute
to diaper dermatitis through secondary effects. Oral medications can affect the motility and flora of the GI tract (e.g.,
antibiotics) or the autonomic control of urination and defecation, especially if given frequently. Some foods, such as
caffeine and citrus juices, are irritating when eliminated from the body. One study reported a higher incidence of diaper rash
in infants given antibiotics or oral glucose 50% solution.15
1
Table 2: Relative Irritancy of Surfactants Found in Skin Care Products
Relative Irritancy Surfactants
High Sodium lauryl sulfate

Sodium dodecyl sulfate
Sodium alkyl sulfate
Sodium or potassium cocoate
Sodium or potassium tallowate
Sodium palmitate
Sodium or potassium stearate
Linear alkyl benzene sulfate
Triethanolamine laurate
Sodium olefin sulfonate
Benzalkonium chloride
Dodecyl trimethyl ammonium bromide
Moderate Sodium ethoxylates

Sodium laureth sulfate
Ammonium laureth sulfate
Relative Irritancy Surfactants
Low Sodium cocoyl isethionate

Sodium alkyl glycerol ether sulfonate
Sodium cocoyl sulfosuccinate
Disodium stearyl sulfosuccinate
Table 3: Chemical/Drug-induced Diaper Dermatitis
Substances that may Cause Contact Dermatitis in the Diaper Area5
Antihistamines, topical Methylisothiazolinone
Bacitracin PABA derivatives, e.g., benzocaine
Balsam of Peru Parabens
Ethylenediamine Penicillins
Lanolin Sulfonamides
Neomycin Thimerosal
Substances to Avoid in the Diaper Area due to Toxicity5
Sensitizer or Toxin Effect
Alcohol Dehydration
Benzocaine and resorcinol Contact sensitivity, methemoglobinemia
Camphor Seizures
Potent topical corticosteroids Cushing's syndrome, atrophic changes, acne, superinfections
Topical salicylates (methyl salicylate) Salicylate intoxication, metabolic acidosis
An approach to assessment of the patient with diaper dermatitis can be found in Figure 1.
Severe or Complicated Diaper Dermatitis
Assess patients further for other possibilities including contact sensitivity, infection or alternative diagnosis when:
a correctly identified rash fails to improve after a week of recommended treatment

pain, itching or inflammation has increased
oozing blisters or pus are present
the dermatitis has not healed in 7–10 days
the dermatitis has an acute onset
the dermatitis is chronic or recurs frequently
there is a complicated secondary infection, urinary tract infection or infection of the penis or vulva
there are systemic symptoms, e.g., fever, diarrhea, nausea, vomiting, rash or skin lesions elsewhere on the body
there are signs of immunodeficiency, deep ulceration, or abuse or neglect
the dermatitis is associated with another disease state
the patient shows behavioural changes.
A diaper rash grading scale with associated description to quantify severity has been proposed. It uses ratings of very
slight, slight, moderate, moderate to severe and severe, to assess skin integrity (ulceration and scaling), erythema (macules
and continuous), rash (papules and edema) and the percentage of the area affected.16
Prevention
Prevention (and treatment) of diaper dermatitis is important for the duration of time the patient wears diapers. Appropriate skin
care practices support skin barrier function and protect the buttocks skin from feces and urine. There is no evidence that any
single method is effective alone.17
Combination methods should address all causative factors, combining nonpharmacologic and pharmacologic measures
according to the following acronym:
A. air, absorptives, antifungals, anti-inflammatories

B. barriers
C. cleansing, compressing
D. diaper
E. education
The first step is to discontinue aggravating factors (see Risk and Aggravating Factors).
Air: It is important to allow “air” drying to diminish the damaging effects of occlusion and maceration, by removing the diaper
for as long as possible during cleansing, treatment and changes. Avoid practices that may cause chapping and burns, such as
drying the buttocks area with a hair dryer, even on the lowest setting, or exposure to infrared lamps. Adult incontinence
products with absorbent cores and breathable outer covers marketed for adults increase aeration. Breathable covers also
create conditions unfavourable to C. albicans survival.1 Absorptives, antifungals and anti-inflammatories are discussed in
Pharmacologic Therapy.
Barriers: Powders are potentially dangerous due to risk of inadvertent inhalation and are best avoided. Cornstarch reduces
friction. It may absorb some moisture, although inefficiently compared with pastes, and it does not wick moisture away from
the skin surface. It may serve as a culture medium for C. albicans, promoting or aggravating diaper dermatitis.18 Talc is a finely
milled form of hydrous magnesium silicate which is more a lubricant than an absorbent. It reduces friction, and adheres well to
the skin. However, respiratory problems may develop from aspiration of cornstarch or talc unless it is applied to a cotton puff
or to the hands and dabbed on.19 Metabolic alkalosis has been reported in an infant whose diaper rash was treated with
baking soda.20 When powders are applied to broken or oozing skin, a crust may form leading to infection.
Cleansing should be gentle, and the frequency of washing should be decreased. A soft cloth should be used. The area should
be well rinsed if possible. Cleansing should occur after urination or defecation. Rinsing with water and wiping with cotton wool
balls is sufficient to remove urine.21 Mild soaps should be used for feces removal. After cleansing, the area should be blotted
dry. An alternative to soap is a soapless cleanser or an oil-in-water lotion. This is especially important for the atopic child
whose skin is further irritated by frequent washing with soap and water. Irritant surfactants should be avoided.
Diaper wipes are composed of a substrate with cleansing agents and/or emollients. In studies among healthy infants,
cleansing with a diaper wipe resulted in significantly lower erythema and surface roughness compared with water used with a
cotton washcloth or cotton wool balls.22,23 Avoid commercial diaper wipes if they contain chemicals such as alcohol,
fragrance, lanolin, methylisothiazolinone or soap, especially if they add to skin irritation. Wipes without sensitizers were as well
tolerated as water in daily cleansing in infants with atopic dermatitis.22 Most wipes should be discontinued if the skin is
broken.
Combination products for managing adult incontinence offer another approach for improving diaper skin conditions through
cleansing. Use of a system including an adult brief (diaper) and 2 wipes for cleansing/protection in a waterproof pouch
resulted in a greater frequency of using wipes for cleansing and decreased the time for care.24
Compressing: If there is oozing and crusting with acute inflammation, compressing with wet dressings (tap water, normal
saline, astringents) or oatmeal baths has been recommended. However, no studies compare astringents to plain tap water or
normal saline, which have less risk of further damage to the skin.
Compresses cool and dry the skin through evaporation. They reduce inflammatory blood flow, cleanse the skin of exudates,
crusts and debris, and help maintain drainage of infected areas through vasoconstriction. They are indicated in acute
eczematous conditions with oozing and crusting, which can be seen in acute diaper dermatitis. The solution should be tepid or
room temperature, although cold solution is effective to relieve itch in skin that is otherwise not symptomatic. A nonirritating
gauze or thin cloth is soaked with solution, then wrung gently so it remains wet but not dripping. The compress is applied to
the skin, removed, remoistened and reapplied every few minutes (“a minute on, a minute off”) for 20- to 30-minute periods, 4–6
times daily. After using a compress, a lotion may be applied to the skin; however, avoid occlusion with an ointment. Instructions
for compressing are different from instructions for soaking. Although the same solutions are used, opposite effects are
produced: soaks are used for chronic dry dermatitis and will rehydrate the skin. If used in weeping conditions, they will
macerate and cause harm (see Atopic, Contact, and Stasis Dermatitis, Wet Dressings). Powders are not applied to any
exudative lesion because they crust, causing bleeding on removal and increased risk of infection. Oilated or nonoilated oatmeal
baths may soothe diaper dermatitis. Irritant contact dermatitis has been reported from overuse of acid pH cleansers.25
Diapers: As a barrier and an absorptive device, an appropriately chosen diaper can prevent and ameliorate diaper dermatitis.
Inappropriately chosen diapers may exacerbate this condition. Diapers should be changed as frequently as possible to reduce
occlusion, decrease contact time of urine and feces with skin, reduce mechanical irritation and trauma and discourage onset of
secondary infection. The practice of double-diapering to reduce the frequency of diaper changes is not recommended. The
apparently unsoiled part of the diaper should never be used to wipe or clean the diaper area. Plastic pants should be avoided
with cloth diapers.
Infant diapers have evolved from the use of cloth (covered with plastic, impermeable overpants), to disposable diapers with a
cellulose core and a plastic outer cover, to disposable diapers with highly absorbent polymers (known as absorbent gelling
material and referred to as AGM diapers) and to AGM diapers with a permeable or “breathable” outer cover.1 A comparison of
the technologies showed that reusable cloth diapers absorb urine but do not reduce humidity or remove skin surface moisture,
especially when used with plastic pants. Disposable diapers with AGM absorb urine/moisture and wick it vertically away from
the skin, reducing maceration and mixing of urine with feces and prevent rewetting over time. The net effect is decreased
humidity compared with cloth. Infants wearing breathable disposable diapers experienced significantly less diaper dermatitis
including confirmed infection with Candida compared with standard, nonbreathable disposable diapers in a series of double-
blind clinical trials. Severe dermatitis was reduced by 38–50%.26 However, a systematic review found that there was
insufficient good-quality evidence to draw any conclusions about use of disposable diapers and prevention of diaper
dermatitis.27
Choice of diaper is highly personal and steeped in controversy. Some consider cloth more economical, comfortable and
environmentally friendly. Others prefer the convenience of disposable diapers. Diapers may also be therapeutic for atopic
children, as the “tropical” environment may effectively rehydrate dry, atopic skin.28
Care of cloth diapers: Cloth diapers should be washed with mild detergent, avoiding water softeners or harsh soaps, and may
be rinsed of bleach (if it has been used in the wash) by running through an additional rinse cycle. A cup of vinegar in the final
rinse water lowers the pH of the diapers. Commercial diaper services rinse diapers of harsh chemicals, sterilize them and iron
them to kill bacteria, fungi and yeasts.
Education: Patients and caregivers must understand both prevention and treatment of diaper dermatitis (see Diaper Rash—
What You Need to Know).
Diaper dermatitis represents a persistent challenge to the epidermal barrier. Although episodes of dermatitis may resolve,
barrier function usually remains compromised and further minor skin damage increases the risk of injury and future episodes.
Skin condition should be examined at every diaper change or incontinence episode, and patients should be assessed for risk
factors and contributing issues.
Hydration should be minimized through the use of diaper products that wick moisture away from the skin surface, minimizing
contact with wetness, frequent diaper changes, selection of properly sized diapers and ensuring the skin surface is dried after
cleansing.
Cleansing should be gentle, using soft cloths with minimal rubbing and avoiding products with known irritants, fragrance or
alcohol.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Baby Care
Products: Diaper Rash.
Topical treatments should be used as preventive and active therapy. Treatment should begin at the first appearance of signs
and symptoms such as slight erythema, dryness, dermatitis or abnormal skin anywhere in the diaper area. Re-evaluate and
modify plan if condition worsens or does not show improvement.
An approach to prevention and treatment of diaper dermatitis is presented in Figure 2.
Barrier Products
Vehicles as Delivery Systems: The type of vehicle and manner of use in the clinical setting are important considerations.
Ideally, topical treatments for diaper dermatitis should provide a semipermeable film or layer over the damaged skin to
facilitate barrier repair, provide a physical shield between the skin and the irritants, remain in place on the skin (not removed
by feces), maintain the acid mantle (acidic pH) and allow for ease of cleansing the skin (minimize stripping).1 The success
of therapy for diaper dermatitis depends as much on the choice of vehicle as on the choice of active ingredients.
Thicker products (pastes, creams and ointments) are usually water-in-oil emulsions that have low water content or are
anhydrous. Lotions and emulsion creams cool and protect mechanically. Ointments protect, soften and lubricate. Powders,
either loose or incorporated into pastes, protect the skin mechanically, absorb fluid and decrease friction. However, if the
powder is within a hydrophobic material or lipid (e.g., zinc oxide powder in petrolatum), external water cannot be
absorbed.29 Pastes combine the actions of both powders (absorb, protect, decrease friction) and the ointment bases
(soften, lubricate) into which they are incorporated. Pastes and petrolatum-based barriers can be occlusive.
Barrier bases are the mainstay of topical diaper dermatitis therapy and can be of 2 types: those that provide a water-
impermeable barrier only, and those that provide a barrier and are also water-absorptive. Since the 2 essential contributions
to the development of the dermatitis are loss of barrier function and overhydration, barrier-absorptive bases are preferred
as they both lessen the overhydration and create a barrier. Both types of products provide a physical barrier to shield the
skin from outside irritants, protect surfaces that are healing, and lubricate against maceration and friction. Barrier base
products usually contain a mixture of ingredients including zinc oxide, petrolatum, mineral oil, eucerin, lanolin, or a silicone
base in the vehicle, with or without absorptive ingredients such as talc, cornstarch or kaolin. Some may also contain
astringents such as hamamelis (witch hazel), which may be a sensitizer, or vitamins such as A, or A and D in the form of
cod liver oil. Preservative and fragrance may be present. Some of these added constituents are of dubious value, or may be
contact sensitizers. Avoid first aid products not approved for diaper dermatitis as they may contain other harmful
ingredients such as an unnecessary antibiotic or a sensitizing anesthetic.
The use of barriers is recommended as both prevention and treatment of diaper dermatitis. Use will help prevent dermatitis
in all diaper wearers with risk factors present, and especially in newborns with frequent urination and defecation, those with
sensitive skin or patients with coexisting conditions. Thicker, absorptive barriers are suggested for treatment of an existing
dermatitis.
Barrier-only products that are suitable for use in diaper dermatitis are either oleaginous hydrocarbon bases (petrolatum),
absorption bases (anhydrous lanolin, anhydrous Eucerin) or silicone bases. Petrolatum (yellow or decolourized white) is a
translucent, oil-phase greasy preparation with no capacity to absorb moisture. It traps moisture present on the skin surface
and may lead to maceration if applied to overhydrated skin. As a mineral-derived product, it may be irritating to inflamed
skin. Though widely recommended and anecdotally effective for prevention of diaper dermatitis, evidence is lacking. One
study showed no significant difference in preventing diaper rash when petrolatum jelly was compared with controls.15
Anhydrous lanolin, a sheep wool–fat product, and anhydrous Eucerin, a wool fat alcohol extraction that is less sticky and
has less odour, are 2 translucent, oil-phase “absorption” bases (so called due to their ability to absorb water if needed in
compounding). However, these wool-derived substances are strong contact allergens and should be avoided in patients
who have allergic contact dermatitis, open or inflamed skin or atopic dermatitis. Lanolin-like products may be components
of commercial combination bases, wipes or oils for diaper dermatitis; labels should be scrutinized carefully when selecting
products for patients who could be sensitized. Wool fat absorption bases are therefore less widely suitable than oleaginous
bases for diaper dermatitis. Silicone-based products containing dimethicone or dimethylpolysiloxane are synthetic bases
that are water-repellent only, and soothe by protecting against irritants. Ceramide products used as protectants have not
been compared with other barriers. In principle, they assist in maintaining normal barrier function and reduce
transepidermal water loss by increasing the ceramide/cholesterol ratio, which is reduced in irritated skin. They do not
absorb excess moisture.
Bases that are both barrier and absorptive are usually creams or pastes with various percentages of zinc oxide. Zinc oxide,
a mild antiseptic, is astringent and also functions as an absorptive powder as concentrations increase. Moderate
concentrations of zinc oxide (e.g., 15%) are usually creams that are easy to spread and good for daily maintenance to
prevent diaper dermatitis. Higher concentrations, (up to 40%), are stiff, have enhanced absorptive and astringent properties,
and are suitable for treatment of diaper dermatitis. Pastes are especially useful for diaper dermatitis associated with
diarrhea or increased stool output.30 They may need to be spread gently with a tongue depressor or spatula, and removed
with mineral oil. Although zinc absorption through the skin has been reported in a child with acrodermatitis enteropathica,
zinc is a naturally occurring essential mineral and part of daily dietary requirements.31 A plain zinc oxide barrier is
preferable to those that may sensitize due to the presence of other constituents, such as aloe vera. Vitamin A and a vitamin
B5 derivative (dexpanthenol) are popular additives to diaper rash barrier products, but no benefit has been demonstrated
compared with zinc oxide, lanolin and petrolatum alone.32
Glycerin is an active humectant at concentrations of 20–45%. Frequently, lower concentrations of glycerin are present to
ensure shelf-life of a product only and are inactive as humectants.
A Cochrane review examined the evidence on vitamin A, a component of the skin protectant cod liver oil, for treatment
and/or prevention of diaper dermatitis. One study investigating 114 newborns reported no differences in diaper dermatitis
for an ointment with vitamin A compared with the vehicle;33 it should not be recommended.
Topical films: Solutions and sprays that dry to form a semipermeable barrier film on the skin are alternatives. They are
intended to remain in place to protect the skin from direct contact with irritants and to facilitate skin barrier repair. They can
be useful alternatives to topical creams whose effectiveness can be limited by poor persistence of effect and removal with
diaper changes. The films can minimize skin stripping from cleansing procedures. One example is Cavilon No-Sting Barrier
Film, delivered from a volatile silicone solvent to form a semipermeable film, which is flammable. It can be used on infants
older than 1 month (not for use on preterm infants). Another film is Sureprep No-Sting Protective Barrier Wipe, delivered to
the skin from a nonflammable water-based solution. Trials of these products lacked sufficient numbers of subjects to
conclusively determine the effectiveness and the time course of improvement relative to conventional barrier creams.34,35
Topical Antifungals
Topical antifungal preparations with antiyeast activity are usually necessary in diaper dermatitis showing signs of barrier
compromise such as inflammation; it is likely critically colonized with Candida due to transfer from the bowel via feces. This
may occur before classic signs of a Candida infection (diaper dermatitis which is beefy red with a lacy, scaly border and
satellite pustules, involving the creases) appear. Topical imidazoles are the treatment of choice. Topical miconazole or
clotrimazole are generally 70–90% effective against Candida within 1 week of treatment. The polyene antifungal nystatin is
another antiyeast preparation with slightly less efficacy than the imidazoles (approximately 70% effectiveness). Nystatin
typically requires longer treatment (about 2 weeks) for symptoms to resolve. Nystatin is known to cause staining of fabric.
Topical miconazole was reported to be well tolerated and significantly more effective than zinc oxide/petrolatum for
treatment of diaper dermatitis complicated by candidiasis.36,37 A randomized, controlled study found clinical response to
clotrimazole superior to nystatin in infants with diaper dermatitis.38
Topical ciclopirox provided a significant reduction in severity and an increase in cure rate among infants with diaper
dermatitis in 1 study.39 It is often recommended because of additional broad-spectrum antibacterial and anti-inflammatory
effects. It is considered superior to nystatin and inferior to imidazoles in terms of clinical efficacy.
One small study found that topical application of a liquid menthol product prior to topical clotrimazole therapy significantly
improved erythema and pustules and time to complete healing, compared with clotrimazole alone.40
Antifungal preparations function to keep the antifungal at the skin surface, where it can release the medication to attack the
yeast in the stratum corneum. They should be applied first, followed by the barrier cream. Once the inflammation has
subsided, discontinue the antiyeast preparation and continue treatment with the barrier cream.
Topical Corticosteroids
Corticosteroids: Topical hydrocortisone 0.5–1 % can be applied to the occluded area under the diaper. Use caution in
children under 2 years of age. Hydrocortisone can be added to the regimen for short periods of 1–2 weeks only, if severe
inflammation exists. It can be used with a barrier cream if the diaper dermatitis is an irritant dermatitis, or with an antiyeast
preparation for prevention or treatment of Candida. If used as a cream or ointment with an antiyeast cream in a
polyethylene glycol base, apply the corticosteroid first.
More potent corticosteroids are not recommended as absorption due to heat and moisture can cause serious side effects.
Hydrocortisone 1% is sometimes added extemporaneously as a powder to commercial antifungal preparations to facilitate
adherence. Equal parts of hydrocortisone and antifungal creams should not be mixed as the resultant product contains half
the required concentration of each active agent, and half the required concentration of preservative. This may lead to a lack
of therapeutic response and the possibility of resistance arising with continued use. Once inflammation subsides, the
corticosteroid should be discontinued.
Combinations of antifungals and mid- to high-potency corticosteroids (e.g., nystatin and triamcinolone, clotrimazole and
betamethasone dipropionate) are not recommended because of the risk of corticosteroid-induced skin atrophy and the
ability of the occlusive environment to enhance penetration.41
Pharmacologic options for the prevention and treatment of diaper dermatitis are summarized in Table 5.
Natural health products for diaper dermatitis may include mixtures of oils of sandalwood, peppermint and lavender,
calendula cream, chickweed root, powdered comfrey root, goldenseal root powder, sweet almond oil, and beeswax heated
in a cast-iron pan and strained through cheesecloth before applying to the diaper rash.9 Evidence is sparse. One study
found olive or sunflower oil had a negative effect on the lipid structure of the skin barrier in neonates, though the clinical
importance of this finding is unknown.42 Another study showed both topical Calendula officinalis ointment and topical aloe
vera cream improved severity of diaper dermatitis in infants; however, calendula was significantly more effective. No
adverse effects were reported.43 Significant improvement over 5 days was found in a preliminary trial in infants with
moderate erythema with or without maceration who were treated with honey, olive oil and beeswax, and the number of
candidiasis cases decreased.44 A derivative of guaiac and chamomile oil, guaiazulene, had beneficial effects compared
with placebo when applied to high-risk neonates with diaper dermatitis recalcitrant to extended antifungal therapy.45
Topical human breast milk has been compared with zinc oxide barrier cream (40%) with no significant difference except
that zinc oxide showed a better decrease in lesion score.46 In another study topical human breast milk was as effective as
hydrocortisone 1% ointment after one week in treatment of infants with diaper dermatitis.47 Natural health products are
sold with few instructions, may not be regulated as to purity or potential toxicity and should not be recommended.48
Table 4 provides a monitoring framework for patients with diaper dermatitis. Parameters should be monitored by the patient or
the caregiver. Taper therapy appropriately in response to improvement or resolution. The healthcare practitioner should be
responsible for ensuring that the treatment plan remains on schedule, is effective, and that no adverse effects are occurring.
The patient or caregiver should be contacted within 2–3 weeks to determine progress. If allergic reactions occur, discontinue
therapy. If the condition worsens due to irritation, alter therapy. Severe inflammation should be minimal and should disappear
after continued use.
Table 4: Monitoring of Therapy for Diaper Dermatitis

Parameter Expected Change/Timeframe Actionsa
Effectiveness endpoints (dermatitis resolution/control; relief of symptoms): short-term
Inflammation Decrease by 80% within 1–2 wk Taper therapy in response to resolution;

(redness, swelling, if end points not achieved, consider
pain, warmth) further therapy.
Surface area involved No progression
Extension to body None

folds, other local sites
or generalization to
whole body area
Blister formation and No new blisters, cessation of oozing after 1–2

oozing days
Appearance of border None

scale or satellite
pustules
Disruption of sleep Restoration of normal pattern within 2–3 wk

behaviour
Effectiveness endpoints (dermatitis resolution/control; relief of symptoms): long-term
Progression of No progression of severity If end points not achieved, consider

severity further therapy.
Recurrent episodes Lengthening of symptom-free periods

throughout therapy
Safety endpoints (treatment side effects)
Allergic reactions None If allergic reaction occurs, discontinue

therapy.
Severe dryness, Minimal If severe, decrease dose, concentration

irritation (e.g., Should disappear, diminish or be controlled with or frequency of use.
redness, continued use If still no improvement, consider
inflammation, alternative treatment.
stinging)
a
Patient or caregiver should monitor all parameters daily while on drug therapy. Healthcare practitioners should monitor all parameters
after 1–2 weeks of therapy or at next visit.
Algorithms
Figure 1: Assessment of Diaper Dermatitis

Figure 2: Treatment of Diaper Dermatitis
Drug Table
Table 5: Pharmacologic Therapy for Prevention and Treatment of Diaper Dermatitis
Class Drug Dosage Adverse Comments Costa
Onset/Duration Effects
Antifungal ciclopirox olamineb Massage Onset: Clinical Transient Broad- $$
1% into improvement pruritus, mild spectrum
Loprox affected and relief of burning at antifungal.
area and pruritus within application site If using in
surrounding 1 wk combination
skin BID Duration: with barrier
Continue for product, apply
minimum of 4 antifungal
wk first.
Manufacturer
states that
safety and
efficacy have
not been
established in
children <10 y;
however,
ciclopirox has
been studied
in this age
group and is
used in
practice.
Antifungal clotrimazole 1% Massage Onset: Clinical Blistering, Some anti- $$

Canesten, generics into improvement irritation, inflammatory
affected and relief of burning, and gram-
area and pruritus within pruritus, positive
surrounding 1 wk stinging. antibacterial
skin BID Duration: action.
Continue for Cross-
minimum of 1– sensitivity with
2 wk other azole
derivatives.
If using in
combination
with barrier
product, apply
antifungal
first.
Antifungal miconazole nitratec Massage Onset: Clinical Blistering, Some anti- $$

2% into improvement irritation, inflammatory
Micatin, Monistat affected and relief of burning, and gram-
Derm, generics area and pruritus within pruritus, positive
surrounding 1 wk stinging. antibacterial
skin BID Duration: action.
Continue for Cross-
minimum of 1– sensitivity with
2 wk other azole
derivatives.
If using in
combination
with barrier
product, apply
antifungal
first.
Antifungal nystatin Massage Onset: Within Irritation (rash, Effective only $

generics into 24–72 h after urticaria) against
affected initiation of primarily due to Candida.
area and therapy. preservatives If using in
surrounding Duration: (parabens) in combination
skin BID– Continue for some with barrier
TID minimum of 2 formulations. product, apply
wk May stain antifungal
clothing. first.
Barrier silicone-based Apply PRN Onset: Skin Not irritating. Water- $
Products products in a thick protection is Formulations repellent only.
(dimethicone or layer immediate that contain Soothe by
dimethylpolysiloxane) Duration: Skin additives such protecting
Barriere Cream, protection lasts as lanolin, against
Moisturel Cream about 3 hours. preservatives irritants.
or fragrance
may be
sensitizing.
Barrier zinc oxide 15%, 40% Apply PRN Onset: Skin Not irritating. Astringent and $
Products Zincofax, generics in a thick protection is Formulations antiseptic
layer immediate that contain actions as well
Duration: Skin additives such as absorbent
protection lasts as lanolin, and protectant
about 3 hours. preservatives properties.
or fragrance Effective
may be preventive
sensitizing. measure at
lower
concentrations
(15%).
Highly
effective
treatment at
concentrations
>25%.
Mineral oil
may be used
to remove the
product if
necessary.
If using in
combination
with antifungal
product, apply
antifungal
first.
Corticosteroids, hydrocortisone 0.5%, Massage a Onset for Mild to severe Effective anti- $
topical 1% thin layer pruritus relief is skin irritation. inflammatory
Cortate, Emo-Cort, into the immediate; Rarely, agent.
Prevex HC, generics affected inflammation hypersensitivity Use caution in
area up to relief takes reactions. treatment of
TID PRN about 2 days. children <2 y
due to
Should not increased risk
be used for of absorption.
more than 1 Apply before
wk polyethylene
glycol–based
antifungal
products if
being used in
combination.
a
Cost of 15 g; includes drug cost only.
b
Manufacturer states that safety and effectiveness have not been established in children <12 y; however, ciclopirox has been studied in
children and is used in this population in clinical practice.
c
Manufacturer states that this product is not to be used in children <2 y; however, it is widely used in clinical practice.
Legend: $ <$3 $$ $3–6
Suggested Readings
Coughlin CC, Eichenfield LF, Frieden IJ. Diaper dermatitis: clinical characteristics and differential diagnosis. Pediatr Dermatol
2014;31:19-24.
Coughlin CC, Frieden IJ, Eichenfield LF. Clinical approaches to skin cleansing of the diaper area: practice and challenges.
Pediatr Dermatol 2014;3:1-4.
Klunk C, Domingues E, Wiss K. An update on diaper dermatitis. Clin Dermatol 2014;32:477-87.
Lavender T, Furber C, Campbell M et al. Effect on skin hydration of using baby wipes to clean the napkin area of newborn
babies: assessor-blinded randomised controlled equivalence trial. BMC Pediatr 2012;12:59.
Shin HT. Diagnosis and management of diaper dermatitis. Pediatr Clin North Am 2014;61:367-82.
References
1. Visscher MO. Recent advances in diaper dermatitis: etiology and treatment. Ped Health 2009;3:81-98.
2. Reider N, Fritsch PO. Other eczematous eruptions. In: Bolognia JL Jorizzo JL Schaffer JV, eds. Dermatology. 3rd ed.
Philadelphia: Elsevier Saunders; 2012. p. 219-31.
3. Visscher MO, Hoath SB. Diaper dermatitis. In: Chew A, Maibach HI, eds. Irritant dermatitis. New York: Springer; 2006. p.
37-51.
4. Leyden JJ. Diaper dermatitis. Dermatol Clin 1986;4:23-8.
5. Schanzer MC, Wilkin JK. Diaper dermatitis. Am Fam Physician 1982;25:127-32.
6. de Wet PM, Rode H, van Dyk A et al. Perianal candidosis–a comparative study with mupirocin and nystatin. Int J
Dermatol 1999;38:618-22.
7. Montes LF, Pittillo RF, Hunt D et al. Microbial flora of infant's skin. Comparison of types of microorganisms between
normal skin and diaper dermatitis. Arch Dermatol 1971;103:400-6.
8. Sires UI, Mallory SB. Diaper dermatitis. How to treat and prevent. Postgrad Med 1995;98:79-84, 86.
9. Boiko S. Treatment of diaper dermatitis. Dermatol Clin 1999;17:235-40.
10. Makrides HC, MacFarlane TW. An investigation of the factors involved in increased adherence of C. albicans to
epithelial cells mediated by E. coli. Microbios 1983;38:177-85.
11. Weston WL, Lane AT, Weston JA. Diaper dermatitis: current concepts. Pediatrics 1980;66:532-6.
12. Siegel E, Wason S. Borix acid toxicity. Pediatr Clin North Am 1986;33:363-7.
13. Scheinfeld N. Diaper dermatitis: a review and brief survey of eruptions of the diaper area. Am J Clin Dermatol
2005;6:273-81.
14. Dross C. Ubiquitous preservative blamed for rash of skin allergies CMAJ 2013;185:E712.
15. Alonso C, Larburu I, Bon E et al. Efficacy of petrolatum jelly for the prevention of diaper rash: a randomized clinical trial.
J Spec Pediatr Nurs 2013;18:123-32.
16. Jordan WE, Lawson KD, Berg RW et al. Diaper dermatitis: frequency and severity among a general infant population.
Pediatr Dermatol 1986;3:198-207.
17. Blume-Peytavi U, Hauser M, Lunnemann L et al. Prevention of diaper dermatitis in infants–-a literature review. Pediatr
Dermatol 2014;31:413-29.
18. Belsito DV. The diagnostic evaluation, treatment, and prevention of allergic contact dermatitis in the new millennium. J
Allergy Clin Immunol 2000;105:409-20.
19. Mofenson HC, Greensher J, DiTomasso A et al. Baby powder–a hazard! Pediatrics 1981;68:265-6.
20. Gonzalez J, Hogg RJ. Metabolic alkalosis secondary to baking soda treatment of a diaper rash. Pediatrics 1981;67:820-
2.
21. Furber C, Bedwell C, Campbell M et al. The challenges and realties of diaper area cleansing for parents. J Obstet
Gynecol Neonatal Nursi 2012;41:E13-25.
22. Ehretsmann C, Schaefer P, Adam R. Cutaneous tolerance of baby wipes by infants with atopic dermatitis, and
comparison of the mildness of baby wipe and water in infant skin. J Eur Acad Dermatol Venereol 2001;15:16-21.
23. Odio M, Streicher-Scott J, Hansen RC. Disposable baby wipes: efficacy and skin mildness. Dermatol Nurs 2001;13:107-
12, 117-8, 121.
24. Al-Samarrai NR, Uman GC, Al-Samarrai T et al. Introducing a new incontinence management system for nursing home
residents. J Am Med Dir Assoc 2007;8:253-61.
25. Patrizi A, Neri I, Marzaduri S et al. Pigmented and hyperkeratotic napkin dermatitis: a liquid detergent irritant dermatitis.
Dermatology 1996;193:36-40.
26. Akin F, Spraker M, Aly R et al. Effects of breathable disposable diapers: reduced prevalence of Candida and common
diaper dermatitis. Pediatr Dermatol 2001;18:282-90.
27. Baer EL, Davies MW, Easterbrook KJ. Disposable nappies for preventing napkin dermatitis in infants. Cochrane
28. Wong DL, Brantly D, Clutter LB et al. Diapering choices: a critical review of the issues. Pediatr Nurs 1992;18:41-54.
29. Juch RD, Rufli T, Surber C. Pastes: what do they contain? How do they work? Dermatology 1994;189:373-7.
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Dressings

Introduction
Dressings are intended to protect a wound from damage and contamination, and in some cases promote
healing. The simplest dressing is gauze covering a wound, held in place by adhesive tape. Minor cuts and
scrapes are often covered by self-adhesive strips that combine both gauze and adhesive tape in a
prepackaged format.
Wounds may be chronic (e.g., ulcerations secondary to conditions such as diabetes, peripheral vascular
ulcers and pressure ulcers or “bed sores”). Wounds may be extensive, such as a deep wound or one that has
had tissue torn from it. All wounds, including minor or postsurgical wounds, require dressings that are
specific for the type of wound.
First and foremost, dressings help to stop bleeding and protect the wound from debris, microorganisms and
further damage.1 However, dressings may serve other purposes. An ideal dressing maintains a moist
environment while removing excess exudate to prevent maceration. Wounds that are painful benefit from
dressings that “soothe” nerve endings, e.g., hydrogels, hydrocolloids, sheet gels. Table 1 lists some of the
common characteristics of dressings.
Table 1: Characteristics of an Ideal Dressing

Provides a moist environment—a moist environment will accelerate epidermal migration and
dermal repair.
Provides thermal insulation—a drop in temperature below 37°C delays mitotic activity for up to 4 h.
Is highly absorptive—excess exudate can macerate healthy tissue.
Is impermeable to bacteria—bacteria and other microorganisms can colonize a wound.
Is free of contaminants—sterile technique is paramount in the application of sterile dressings.
Is nonadherent—dressings that adhere to wounds can cause further tissue damage.
Is nontoxic—some antiseptics and hypochlorites are toxic to tissue.
Dressing Types
Gauze
Gauze acts as an absorbent and protectant. It is made by weaving bleached cotton into an open-mesh
cloth. Natural waxes and impurities are removed from the cotton to increase its absorbing capacity.
Gauze is classified either according to its mesh or to the number of threads per inch. Self-adherent
gauze clings to itself; available as pads or rolls, it can be used to wrap a wound without adhesive tape,
e.g., head wound. Viscous rayon and regenerated cellulose are also used in bandages, sometimes in
conjunction with gauze.
Nonadherent gauze is easily removable, yet still protective. It is preferred as the primary dressing, next to
the wound, because of increased comfort. When removed, nonadherent gauze does not leave gauze
threads on the wound surface, nor does it disturb the wound surface by “pulling” or removing any of the
surface. It is prepared by impregnating viscous rayon with an oil-in-water emulsion or by covering the
gauze with a perforated plastic film.
Adhesive Tape
Adhesive tape is used to secure a gauze dressing to a wound. Several kinds are available, including
waterproof, cloth, clear and paper, in a variety of widths. The choice of tape depends upon the size and
type of wound, potential skin sensitivities and personal preference. In general, hypoallergenic and easy-
to-remove adhesive tapes are preferred. For maximal adhesion, apply tape to dry skin. For wounds that
require protection from water or even dirt, a waterproof tape is preferred. Paper or cloth tape reduces the
risk of skin damage for wounds that require frequent dressing changes.
Adhesive tape is a fabric or film evenly coated with a pressure-sensitive adhesive mixture. Today, most
adhesives are acrylate-based; historically, they were rubber-based. Acrylate-based adhesives tend to
produce fewer allergic reactions, and thus are generally termed hypoallergenic. While some reports
estimate adhesive tape allergies occur in 0.3% of patients, true allergic reactions represent a small
fraction of reactions to adhesive tape.2 Rather, the irritation may be considered a non-allergic tape
reaction caused by factors such as the mechanics of tape removal (repeated removal or skin stripping,
removal from a hair-covered area of skin). Combined with an existing dermatitis or a fragile skin surface,
adhesive tape reactions may be severe.
Bandages
Bandages are most commonly a combination of gauze and adhesive tape. They may be self-adhesive or
require further adhesive material.3 Self-adhesive bandages are convenient alternatives to gauze and tape
and include those with adhesive borders on all sides; however, the correct size needs to be chosen for
the wound. The bandage should be large enough to cover the wound completely, yet not too large. If the
bandage is too small, the adhesive may adhere to the wound, making removal difficult, or alternatively, a
portion of the wound will be exposed. If the bandage is too large, the wound will not be covered securely,
impairing healing, and the bandage itself may “bunch” and come loose from the wound. For wounds on
body areas that are difficult to bandage, such as fingertips and knuckles, specially shaped bandages are
available. Butterfly closures are self-adhesive bandages that pull and hold the edges of small wounds
together to encourage healing. Butterfly closures are not a substitute for stitches in larger wounds.
Medicated Dressings
Gauze bandages may be impregnated with therapeutic agents. Medicated gauze allows easy removal
and provides a delivery system for antibiotics and antiseptics. Petrolatum gauze is easily removed and
acts as a protectant for the underlying skin.
Antiseptic-impregnated gauze contains chlorhexidine or povidone-iodine and is used to treat and

prevent infection and ease removal of the dressing. Gauze impregnated with zinc compounds acts as a
protectant and assists in preventing infection. However, there is some controversy regarding the use of
antiseptics on wounds.4 Antiseptic use is not a substitute for appropriate and effective wound cleansing
and debridement. Systemic absorption may complicate the use of antiseptics on wounds covering large
areas (e.g., burns). Dressings containing water or saline aid in débridement (the removal of foreign
material as well as dead tissue) and prevent dehydration. Antibiotics, such as framycetin sulfate, may be
added to gauze to prevent and treat infections.5
Protective Dressings
Protective dressings are either mechanical or physical or a combination of both. Compared with physical
dressings which simply provide a physical barrier, mechanical dressings perform other functions. Some
act as tissue adhesives, absorbents for exudate and wound débridement agents. Most require a
secondary dressing of gauze and adhesive tape to secure them. Table 2 lists suitable dressings based
on the wound to be treated.
Antimicrobials are used for draining, exuding and non-healing wounds where reduction and
prevention of infection is desired. Often these dressings are an integral part of other types of
dressings. Staining of the wound and surrounding skin along with stinging and sensitization can
occur; however, development of resistant organisms has not yet been reported.
Alginates are made from seaweed and create a moist environment while absorbing exudate and
blood. They also have hemostatic properties in that they are able to stop bleeding. Some are higher
in galuronic acid, which means they retain their shape and can be lifted off the wound in one piece.
Others are higher in mannuronic acid and less likely to retain their shape. They are easily washed
out of the wound with sterile saline. An alginate can absorb up to 20 times its weight; however, they
can dehydrate the wound bed and a secondary dressing is often needed to keep an alginate in
place.
Collagen dressings are made from collagen, which is found in skin, bones, ligaments and cartilage.
During wound healing, collagen promotes the deposition and organization of new tissue in the
wound bed. Available as sheets, pads, particles, solutions and gels, these dressings are used in
partial thickness burns, donor sites and ulcers (including pressure ulcers).
Composites combine 2 or more physically distinct products or types in a single dressing to serve
multiple functions. These are becoming more commonly used because of their practicality.
Cyanoacrylate compounds are tissue adhesives used to close small wounds. Collodion is a viscous
solution of pyroxolin in ether and alcohol. Flexible collodion contains camphor and castor oil.
Traditionally, both have also been used to seal small wounds.6
Films are semipermeable, polyurethane membrane dressings that vary in thickness and size. They
can be used alone or in conjunction with other dressings. They can prevent bacterial contamination
but do not absorb exudate so should not be used in wounds with moderate to large amounts of
drainage. However, they do allow fluid to evaporate while keeping the wound moist. They should not
be used alone with infected wounds. Films dressings are comfortable and resistant to shearing.
Foam dressings are the product of advanced polymer technology. They do not adhere to the wound,
yet absorb exudate. Hydrophilic polyurethane dressings can absorb several times their weight in
exudate. Some have an adhesive border and some have a film coating to provide an additional
bacterial barrier. They can be used as either a primary or secondary dressing on a wide variety of
wounds, ranging from partial to full thickness wounds with minimal, moderate or heavy draining.
Hydrocolloids consist of a mixture of pectins, gelatins and sodium carboxymethylcellulose. Ideal
for sloughing or necrotic wounds, they provide an occlusive environment and remove exudate by
mixing with it. These dressings are impermeable to bacteria and other contaminates while
minimizing skin trauma and moulding well to the wound.
Hydrogels are matrices containing a high percentage of water and are available as both sheets and
gels. The sheets are polysaccharides cross-linked with polyacrylamide and are ideal for shallow
wounds like burns. Gels are more suitable for deeper wounds. Because of their high water content,
they do not absorb exudate, but they do help maintain a moist healing environment. If they are self-
adhesive, they may be used as a primary dressing; however, a secondary dressing is sometimes
needed to keep the hydrogel dressing in place.
Choice of Dressing
The choice of dressing depends upon the characteristics of the wound, patient characteristics and cost.
Primary factors are wound etiology, classification, size and shape, and the amount and type of healing that
has occurred. The appearance of the wound edges and surrounding skin influence the dressing size and
adhesive choice. The presence of an exudate or infection must also be considered.
The presence of exudate is a barrier to healing because it inhibits cell growth, contributes to bacterial
imbalance, increases necrotic tissue development and reduces the migration of key cells needed for healing
(e.g., keratinocytes, fibroblasts, endothelial cells). Compression therapy, mechanical devices such as some
débridement materials and absorptive dressings are used to reduce exudate.
The potential need for débridement can affect the choice of dressing. An occlusive dressing maintains a
moist environment which results in autolytic or self-débridement. Wet-to-dry dressings and irrigation will
mechanically débride a wound, but may remove healthy as well as dead tissue. Due to risk of skin sensitivity
and the availability of more effective methods, chemical or enzyme débridement is now reserved for
specific, problematic wounds. Physical débridement (using tweezers to remove debris) is an important step
in preparing a wound for dressing application.
Patient comfort and preference as well as the anatomical location of the wound will affect the choice of
dressing. Factors such as the patient's circulation, nutritional and medical status are considerations, as are
the availability and durability of the dressing itself.
Ailments—Skin Care Products: Dressings.
Table 2: Wound Dressings

Wound
Description/Symptom Types of Suitable Dressings Examples of Productsa
Black surface, hard Hydrogel Duoderm Hydrogel

eschar requiring
rehydration and/or
débridement Hydrocolloid Duoderm CGF, Comfeel Plus
Soft black surface Cadexomer iodine dressings Iodosorb

requiring removal
Green surface which Film dressings Opsite

may be malodorous,
requiring infection
Antiseptic-impregnated gauze Betadine
control
(e.g., povidone-iodine)
Anti-infective–impregnated SofraTulle
dressings (e.g., framycetin
sulfate)
Yellow surface Hydrogel Duoderm Hydrogel
Hydrocolloid Duoderm CGF, Comfeel Plus
Clinical infection Film dressings Opsite

requiring treatment of
infection and control
Antiseptic-impregnated gauze Betadine
of exudate and odour
(e.g., povidone-iodine)
Anti-infective–impregnated SofraTulle
dressings (e.g., framycetin
sulfate)
Granulating surface Alginates Aquacel, Algisite, Kaltostat

requiring creation of
moist environment
Foam dressings Allevyn
and management of
exudate
Film dressings Opsite
Wound
Description/Symptom Types of Suitable Dressings Examples of Productsa
Hydrocolloid Duoderm CGF, Comfeel Plus
Epithelializing surface Film dressings Opsite

requiring creation of
moist environment
Foam dressings Allevyn
Thin hydrocolloid DuoDerm Extra Thin, Comfeel Plus

Transparent
Pain requiring Hydrogels, hydrocolloids and Duoderm CGF, Comfeel Plus

dressings that protect sheet gels are good choices
nerve endings
Hydrophilic dressings such as
sugar paste or cadexomer iodine
exert an osmotic pull and may
increase the pain
Odour, most often Silver sulfadiazine and framycetin Flamazine, SofraTulle, Iodosorb
caused by gram- reduce colonization. Povidone-
negative bacteria iodine has antiseptic activity, but
such as is quickly deactivated in the
Pseudomonas presence of pus; therefore, an
iodine cadexomer dressing may
be preferred since it allows for a
slower release of antiseptic,
extending the antiseptic activity
Excessive exudate Foam and hydrocolloid dressings Allevyn, Duoderm CGF, Comfeel Plus
requiring a balance are good choices to absorb
between the need for exudate. Some types of wounds
a moist environment (e.g., venous ulcers) and wounds
and prevention of in some types of medical
maceration conditions (e.g., hypertension
coupled with venous disease)
produce more exudate. In these
situations, compression
bandages may also be useful to
help reduce exudate by
decreasing venous pressure and
controlling edema
Bleeding needs to be Alginates have hemostatic Aquacel, Algisite, Kaltostat

controlled properties
Infection may need to Antiseptic- or antibiotic- Bactigras, SofraTulle

be controlled by impregnated gauze may be useful
systemic antibiotic
treatment
a
These products are listed as examples only and do not imply recommendation of one brand over another.
Potential Problems when Applying a Dressing

The most commonly used dressings are self-adhesive bandages. Their application is straightforward;
however, care must be taken to ensure the gauze pad is not contaminated through handling. Proper use and
application of any dressing are essential for maximum effectiveness.
Principles of optimal use of dressings include:
Use the correct size. A dressing should be large enough to cover the wound, yet not so large that it
bunches. If 2 or more dressings are needed to cover the wound, the edges should be overlapped to
ensure complete wound coverage
Use sterile technique to apply the dressing with clean hands or gloves. The dressing surface and
wound itself should not be touched. Table 3 describes the steps in applying a dressing
Whatever is applied to the wound will eventually have to be removed. Greasy substances are best
avoided as they may be difficult to remove, causing more damage to the wound. Lint from loosely
woven gauze can also be problematic
The wound must be cleaned prior to applying any dressing. Applying a dressing to a contaminated
wound increases the risk of infection. Flushing the wound with water or sterile saline may be sufficient
If a wound requires débridement or control of bleeding, it should be performed before a dressing is
applied, unless the dressing is specifically designed for débridement or control of bleeding
Sutures may be needed; dressings, even butterfly closures, do not replace necessary sutures
Always consider potential complications such as excessive bleeding and infection. SHARP is an
acronym for signs of infection—swelling, heat, ache, redness, pus. A malodorous wound is usually
infected
Remember that some patients have a higher risk of complications. Individuals with diabetes have
impaired peripheral circulation and wound-healing ability. Nutritional deficiencies may delay healing,
and the use of some medications (e.g., anticoagulants, NSAIDs) may increase the risk of bleeding
Dressings require changing at different intervals. It is a misconception that once a dressing is applied,
there is no need to change it. Manufacturer instructions and wound care protocols need to be
consulted regarding whether a dressing requires changing and the interval recommended.
Table 3: Application of a Dressing

Wash hands and work in a clean area—wearing gloves is an option; the table or countertop may
need to be cleaned with a disinfectant.
Assess wound—if wound is deep or bleeding excessively, seek medical attention.
Control bleeding—allow the wound to bleed slightly, then apply gentle pressure to stop bleeding; a
puncture wound should not be squeezed because the puncturing object may be pushed further into
the wound.
Clean wound—remove large foreign particles, débride if necessary by flushing with water, and wash
with soap and water.
Check for symptoms of infection—swelling, heat, ache, redness or pus (SHARP), and if present,
seek medical attention.
Apply dressing—cover the wound with a dry, sterile gauze dressing using commercially available
materials whenever possible; ensure the dressing extends beyond the edges of the wound, use
adhesive tape to secure the dressing and do not impede circulation by bandaging the wound too
tightly.
Suggested Readings
Advances in Skin and Wound Care. Available from: journals.lww.com/aswcjournal/pages/default.aspx.
Kirsner RS. Wound healing. In: Bolognia JL et al., eds. Dermatology. New York: Mosby; 2003.
Ovington LG, Eastman SR. Moist wound healing. US Pharm 2001:99-108.
References
1. Jeter KF, Tintle TE. Wound dressings of the nineties: indications and contraindications. Clin Podiatr
Med Surg 1991;8:799-816.
2. Smith SM, Zirwas MJ. Nonallergic reactions to medical tapes. Dermatitis 2015;26:38-43.
3. Bolton L, van Rijswijk L. Wound dressings: meeting clinical and biological needs. Dermatol Nurs
1991;3:146-61.
4. Drosou A, Falabella A, Kirsner RS. Antiseptics on wounds: an area of controversy. Wounds 2003;15:1-
7.
5. Brown CD, Zitelli JA. A review of topical agents for wounds and methods of wounding. Guidelines for
wound management. J Dermatol Surg Oncol 1993;19:732-7.
6. Edlich RF, Reddy VR. 5th Annual David R. Boyd, MD Lecture: Revolutionary advances in wound repair
in emergency medicine during the last three decades. A view toward the new millennium. J Emerg
Med 2001;20:167-93.
Drug-Induced Skin Reactions
Sandra Knowles, BScPhm

Pathophysiology
Approximately 6% of all hospital admissions are the result of adverse drug reactions (ADRs).1 Drug-induced skin eruptions are the most
frequently observed adverse reactions to medications. In the Boston Collaborative Drug Surveillance Program, the prevalence of cutaneous
ADRs in hospitalized patients was 2.2%.2 Maculopapular eruptions and urticaria/angioedema are the most frequently reported drug rashes.3
The morphology of cutaneous eruptions (Table 1 and Table 3) may be broadly classified as exanthematous, urticarial, blistering or pustular.
Within each of these categories, the presence of a fever or other accompanying symptoms other than itch signals a more serious reaction,
which requires immediate referral to an appropriate healthcare practitioner (Table 2).17
4
Table 1: Dermatologic Terminology
Bulla A vesicle greater than 0.5 cm in diameter
Desquamation Peeling of the skin
Erythema Abnormal redness of the skin
Exanthem An eruptive disease
Macule A circumscribed, flat lesion less than 0.5 cm in diameter that differs from surrounding skin because
of its colour
Morbilliform Measles-like eruption
Papule A solid, circumscribed, elevated lesion less than 0.5 cm in diameter
Plaque An elevated, flat lesion greater than 0.5 cm in diameter
Purpura Impalpable (macular) unblanchable purple spots
Pustule A vesicle or bulla (usually less than 1 cm in diameter) filled with purulent exudate
Urticaria Hives or an eruption of itching wheals
Vesicle Blister; small, circumscribed, elevation of the skin filled with clear fluid less than 0.5 cm in diameter
Wheal A transitory, elevated papule or plaque caused by edema of the skin
16
Table 2: Clinical Features of Severe Cutaneous Drug Reactions
Fever Palpable purpura
Enlarged lymph nodes Skin tenderness
Arthralgias or arthritis Blisters or epidermal detachment
Shortness of breath, wheezing, hypotension Mucous membrane erosions
Confluent and diffuse erythema Angioedema or swelling of tongue
Facial edema or involvement of central part of face
Table 3: Characteristics of Drug Eruptions

Type of Description Onset Clinical Common Drug Treatment Testing
Eruption after Features Causes
Initial
Exposure
Exanthematous Without fever: 7–10 Rash only Antiepileptic drugs, Symptomatic Mononucleosis
Simple days beta-lactam therapy (e.g.,
antibiotics, antihistamines,
sulfonamide soothing baths,
antibiotics2 topical
corticosteroids)
With fever: Drug 14–21 Fever, rash, Allopurinol,5 Systemic cortico- CBC, liver
rash with days (up eosinophilia, antiepileptic drugs steroids, enzymes,
eosinophilia and to 3 internal organ (carbamazepine, symptomatic urinalysis,
systemic months) involvement lamotrigine, therapy thyroid
symptoms (may be phenobarbital, function tests
(DRESS) also asymptomatic)
phenytoin),6
known as drug
dapsone,
hypersensitivity
nevirapine,
syndrome
sulfonamide
reaction
antibiotics
Urticarial Without fever: Minutes Urticaria ± ASA,7 ACE Symptomatic Skin test for
Urticaria and/or to hours angio-edema relief (e.g., penicillin, if
inhibitors,8
angioedema antihistamines, suspected as
penicillins,
topical causal agent
NSAIDs,7 opioids, corticosteroids);
radiocontrast angioedema
media, requires
sulfonamide immediate
antibiotics therapy with
epinephrine
With fever: Serum 7–21 Fever, rash, Bupropion,9 Symptomatic

sickness–like days arthralgias ± treatment
cefaclor,10
reaction lymph- (including
adenopathy minocycline,11 antipyretic,
penicillins, antihistamine);
rituximab,12 short course of
sulfonamide oral
antibiotics corticosteroids in
patients with
severe symptoms
Blistering Without fever: Hours to Solitary Acetaminophen, Symptomatic

Bullous fixed days erythematous barbiturates, therapy (e.g.,
drug eruption macules that NSAIDs, moisturizer,
may blister and sulfonamide topical
that recur in the antibiotics, corticosteroid)
same skin area tetracycline
after
readministration
of drug
With fever: SJS, 7–14 Targets ± Allopurinol,13 Supportive CBC, liver

TEN days epidermal antiepileptic drugs measures, enzymes,
detachment, (barbiturates, intravenous urinalysis, skin
mucous carbamazepine, immune globulin biopsy
membrane lamotrigine, (IVIG),
involvement phenytoin), NSAIDs cyclosporine
(especially
piroxicam),14
sulfonamide
antibiotics
Pustular Without fever: 7–21 Atypical areas: Androgens, Topical tretinoin

Acneiform days arms, legs. No antiepileptic drugs, (if drug cannot be
comedones corticosteroids discontinued)
(systemic),
epidermal growth
factor receptor
inhibitors (e.g.,
cetuximab,
erlotinib, gefitinib),
isoniazid, lithium
With fever: AGEP ≤10 days Many pustules Beta-lactam Symptomatic CBC, skin
on diffuse antibiotics, calcium therapy, biopsy
erythematous channel blockers, corticosteroids if
base. Fever. 50% quinolones,15 severe
have other macrolide
cutaneous antibiotics
lesions. 25%
have mucosal
erosions
Abbreviations: AGEP = acute generalized exanthematous pustulosis; CBC = complete blood count; SJS = Stevens-Johnson syndrome; TEN = toxic
epidermal necrolysis
Exanthematous Eruptions
Simple Eruptions
Exanthematous eruptions, also known as morbilliform or maculopapular eruptions, are the most common cutaneous ADRs. These
eruptions have been reported to account for approximately 95% of all drug-induced cutaneous eruptions.18 They usually start as
erythematous macules and papules on the trunk, become confluent and later spread symmetrically to the face and limbs; there is no
evidence of blistering or pustulation. Resolution occurs with a change in colour from bright red to a brownish red. This colour change
may be followed by scaling or desquamation. Pruritus is a frequent clinical symptom but is not necessarily present. Simple eruptions
usually begin within 7–10 days of starting therapy and resolve within 7–14 days after discontinuation of the drug.19
Complex Exanthems
Drug rash eosinophilia and systemic symptoms (DRESS), also known as the drug hypersensitivity syndrome reaction, is a complex
drug reaction that includes fever, skin eruption (usually exanthematous), eosinophilia and internal organ involvement such as
hepatitis, nephritis or agranulocytosis, although the internal organ involvement may be asymptomatic.20 The syndrome usually begins
with fever 2–3 weeks after initial drug exposure, and patients often initially complain of malaise.17 In patients with a history of
DRESS, re-exposure to the offending agent may lead to symptoms within 1 day. DRESS is not related to dose or serum concentration
of the drug. Although symptoms resolve in most patients after discontinuation of the drug, in rare instances some patients develop
autoimmune disease and/or production of autoantibodies after resolution of DRESS.21,22 This can include development of type 1
diabetes, autoimmune thyroid disease or lupus erythematosus (see Photo, Hypersensitivity Syndrome Reaction.)
Photo 1: DRESS (Hypersensitivity Syndrome Reaction)
DermNet New Zealand
Urticarial Eruptions
Simple Eruptions
Urticaria, characterized by extremely pruritic, red, raised wheals of varying sizes and shapes, and angioedema (affecting deep dermal
and subcutaneous tissues) are reversible types of edema affecting the skin. In general, individual lesions of urticaria last for less than
24 hours, although new lesions continually develop. Many medications can cause urticaria, angioedema or both; other causal agents
are food, physical factors (e.g., cold, pressure), infections and idiopathic factors.23 Medications account for only 5–10% of urticaria
cases. Adverse reactions to ACE inhibitors, manifesting as angioedema, may occur within hours of starting the drug but can occur as
late as 1 week to several months into therapy.24
Complex Eruptions
Serum sickness–like reactions are defined by fever, rash (usually urticarial) and arthralgias occurring 1–3 weeks after drug initiation.
In contrast to true serum sickness, serum sickness–like reactions are not associated with immune complex formation, vasculitis or
renal lesions. See Photo, Serum Sickness-like Reaction.
Photo 2: Serum Sickness–Like Reaction
DermNet New Zealand
Blistering Eruptions
Simple Eruptions
Fixed drug eruptions usually appear as pruritic, erythematous, bright red or dusky red macules that may evolve into an edematous
plaque. In some patients multiple lesions may be present. Blistering and erosion may occur on mucosal surfaces, especially the
genitalia and lips, and some patients may complain of burning or stinging on the affected skin sites. Fixed drug eruptions recur in the
same skin area after readministration of the causative medication.25
Complex Eruptions
Serious dermatologic eruptions include Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The typical course of
SJS or TEN consists of extreme illness, including fever and malaise, with generalized tender or painful erythema of the skin followed
by extensive epidermal necrosis and sloughing of skin or mucous membrane leading to marked loss of fluids and electrolytes17.
Diagnosis of SJS versus TEN is based on the extent of epidermal detachment: for SJS <10% of body surface area, SJS/TEN overlap
10–30% and TEN >30%. These conditions predispose the patient to pneumonia and septicemia; mortality as high as 30% has been
reported when these complications occur (see Photo, Toxic Epidermal Necrolysis).
Photo 3: Toxic Epidermal Necrolysis
DermNet New Zealand
Pustular Eruptions
Simple Eruptions
Drug-induced acne may appear in atypical areas, such as arms and legs, and comedones are usually absent (see Photo, Acneiform
Eruption). An acneiform eruption often occurs following treatment with epidermal growth factor receptor inhibitors (e.g., gefitinib,
erlotinib, cetuximab). The acneiform rash is often accompanied by paronychia, dry skin and skin fissures. The eruption is dose
dependent, with respect to both incidence and severity.26
Photo 4: Acneiform Eruption
DermNet New Zealand
Complex Eruptions
Acute generalized exanthematous pustulosis (AGEP) is characterized by acute onset, fever, and a cutaneous eruption with
nonfollicular pustules. Generalized desquamation occurs 2 weeks after the initial reaction (see Photo, Acute Generalized
Exanthematous Pustulosis.)
Photo 5: Acute Generalized Exanthematous Pustulosis
DermNet New Zealand
Other Skin Eruptions
27
Photosensitivity
Photosensitivity is an adverse cutaneous response to normally harmless doses of ultraviolet radiation. Ultraviolet A (UVA) rays are
responsible for the majority of photosensitivity reactions. There are 2 types of photosensitivity reactions: phototoxicity and
photoallergy.
Phototoxicity, the more common type, refers to an increased reactivity of the skin to ultraviolet (UV) radiation. This can occur on the
first exposure to a drug, is dose related and is confined to exposed areas of the skin (e.g., face, neckline, back of the hands, arms,
forearms and tops of feet). It generally resembles an exaggerated sunburn. These reactions do not contraindicate continued
treatment with the drug, or its reintroduction, as long as effective protection against sunlight is ensured. Drugs associated with
phototoxicity include amiodarone, fluoroquinolones, methotrexate, phenothiazines and tetracyclines. See Prevention and Treatment
of Sun-induced Skin Damage, Table 1: Medications That May Cause Phototoxic Reactions.
Photoallergic reactions involve the immune system and therefore require prior sensitization to the drug. Photoallergy is delayed,
usually occurring within 24–48 hours of exposure. Pruritus may occur prior to the onset of the cutaneous eruption. The lesions are
often eczematous (e.g., with erythema, vesicles and scaling) and may spread beyond exposed areas. Carbamazepine, chloroquine,
NSAIDs, and sulfonamides have been reported to cause photoallergic reactions.
Contact Dermatitis
Contact dermatitis is an inflammatory reaction of the skin that results from direct contact with a causative agent.28 Most cases are
either allergic contact dermatitis (e.g., poison ivy, nickel) or irritant contact dermatitis (e.g., chemicals, hot peppers). See Atopic,
Contact, and Stasis Dermatitis.
Goals of Therapy
Attempt to determine causality of the drug eruption
Control symptoms associated with the drug eruption (e.g., pruritus)
Provide patient education about drugs to avoid and those which can be used in the future
For patients with photosensitivity reactions, provide information regarding preventive measures (e.g., avoiding UV radiation, wearing
broad-spectrum sunscreen)
Report all unexpected or serious ADRs or reactions to recently marketed drugs to Health Canada, through the Canada Vigilance
Program or through one of the Canada Vigilance Regional Offices
Patient Assessment
Stepwise assessment of patients with possible drug-induced skin reactions is described in Figure 1.
Patients with a drug eruption require referral to an appropriate healthcare practitioner. Although the rash may be self-limiting and require only
self-care measures, patients may require alternative therapy (e.g., a patient develops a nonspecific maculopapular rash 7 days after starting
lamotrigine for a seizure disorder, the lamotrigine is discontinued, and now an alternative drug is needed for the seizure disorder). Many drug
eruptions are more complex in that they are also associated with systemic signs. A patient who develops any systemic symptom such as
malaise, fever or shortness of breath requires immediate medical care since this may signal a more serious reaction.29
Since many skin diseases mimic drug reactions, it is important to carefully evaluate other causes of the cutaneous eruption. For example,
guttate psoriasis may develop in a person being treated with penicillin for streptococcal infection, but the skin lesions are those of psoriasis
and not a drug reaction. Differential diagnoses often include viral exanthems (e.g., infectious mononucleosis, rubella or roseola, see Viral
Skin Rashes), bacterial infections (see Bacterial Skin Infections: Impetigo, Furuncles and Carbuncles), Kawasaki disease, collagen vascular
disease and neoplasia. Disease states can also act as cofactors in the development of a cutaneous eruption. For example, the presence of
infectious mononucleosis raises the risk of ampicillin- or amoxicillin-induced exanthematous eruptions from 3–7% to 60–100%. As well,
between 44% and 83% of HIV-infected individuals experience a dermatologic adverse reaction with sulfamethoxazole/trimethoprim, whereas
these events occur in less than 10% of the general population.30
Cutaneous reactions to drugs frequently occur in complicated clinical scenarios that may include exposure to multiple agents, in which case
a timeline should be developed. It is important that a detailed history be obtained for evaluation of an adverse drug reaction. This includes
dosage, rechallenge and dechallenge, and onset of reaction. A history of prior exposure to the drug and related compounds is also
important. If a patient has become sensitized to a drug they have received previously, on re-exposure to that drug the rash may appear
sooner. New drugs initiated within the preceding 3 months are more likely causative agents, as are drugs that have been used intermittently,
including nonprescription medications and natural health products.31 Although excipients do not cause ADRs in most individuals, there are
isolated case reports of excipients causing skin reactions.32
The final step in the assessment of a patient with a cutaneous eruption is to determine the probability of each potential drug cause. A
cutaneous eruption is commonly mislabelled as a drug reaction. This misdiagnosis may unnecessarily limit the future use of a particular
medication or any related compound. It is important to document the possible drug reaction in the patient's medical and pharmacy records
to ensure that future therapies are not pharmacologically and/or chemically related to the suspect drug.
Many drug-induced skin eruptions, such as urticaria, are often pruritic. Dry skin and overheating can exacerbate pruritus. Overbathing, hot
water, harsh soaps and bubble bath preparations dry and irritate the skin and should be avoided.33 A simple physical measure is cooling the
skin by tepid showering. Four tablespoons of baking soda in the bath may also help to relieve pruritus associated with urticaria. Tap water
compresses can be used on blistering lesions; moisten gauze or other thin cloth in warm tap water and apply for 20 minutes 4–6 times daily.
Alternatively, compresses can be applied intermittently, 1 minute on 1 minute off, for 20 minutes. Oral lesions can be treated with warm
water or saline rinses. Advise patients to avoid factors that may enhance pruritus, such as wearing of tight elasticized apparel or coarse
woolen fabrics.
Discontinuation of the offending drug is considered paramount in the management of patients with cutaneous eruptions. However,
in some cases the drug may be continued and the reaction “treated through”.34 This decision is influenced by the severity and
probable course of the reaction, disease for which the drug was prescribed, ease or difficulty with which the reaction can be
managed and the availability of chemically unrelated drugs with similar pharmacologic properties.35
Table 4 addresses pharmacologic management of drug-induced skin reactions.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Analgesic Products:
External Analgesics; Cough, Cold and Allergy Products; Skin Care Products: Dermatitis and Dry Skin.
Both traditional H1-antagonist antihistamines and nonsedating antihistamines are effective in the treatment of pruritus associated with
urticaria.36 See Allergic Rhinitis for adult and pediatric doses of oral antihistamines. The addition of H2-antagonist antihistamines (e.g.,
ranitidine, famotidine) has been used in some patients with chronic urticaria with some initial benefit;36 however, patients with acute drug-
induced urticaria do not generally require additional therapy with H2-antagonist antihistamines. Patients whose symptoms do not improve
within 5–7 days require further assessment and/or treatment. The use of topical antihistamines, such as those containing
diphenhydramine, is not recommended due to risk of allergic contact dermatitis as well as increased systemic absorption when applied to
open lesions. Patients with urticarial lesions should avoid NSAIDs or ASA since these agents may exacerbate urticaria; they are common
causes of drug-induced urticaria.
Bathing with colloidal oatmeal bath preparations is helpful for pruritus. Unscented moisture cream or white petrolatum should be applied to
the skin while it is slightly damp to retard water evaporation. Topical agents may be kept in a refrigerator because the physical cooling
enhances their antipruritic effect.
Topical cream or lotion astringents, such as plain calamine lotion or zinc oxide cream, can also be used. The use of cooling salves such as
menthol 0.25–0.5% or camphor 0.25–0.5% cream may be helpful although they may occasionally be irritating. Another local treatment is
half-strength hydrogen peroxide rinses for oral lesions.
Counsel patients with photosensitivity reactions to stay out of the sun until the reaction resolves, or to wear sunscreen and protective
clothing. Exposed areas should be covered with a sunscreen that protects in the UVA range with a minimum SPF of 15–30. See Prevention
and Treatment of Sun-induced Skin Damage for a further discussion of sunscreens. Mild to moderate phototoxic reactions can be managed
as ordinary sunburn (e.g., oral analgesics, cooling compresses or baths, emollient lotions).27
Topical corticosteroids are often used in the management of patients with drug-induced skin eruptions. Choice of potency and vehicle will
depend on the body area affected and the extent and severity of the reaction. Only hydrocortisone 0.5–1% should be used on the face and
intertriginous folds. Ointments are more occlusive and are preferred for dry or scaly lesions, whereas creams are used in moist areas since
they are more drying. Lotions are useful for the scalp and other hairy areas or for application to large body areas. The topical corticosteroid
should be applied sparingly, with gentle massage, onto the affected area 2–4 times a day. If the skin lesions persist or worsen after 5–7
days of topical corticosteroid therapy, the patient should seek further assessment and/or treatment. For more detailed information on the
use of topical corticosteroids, see Atopic, Contact, and Stasis Dermatitis.
Systemic corticosteroids are often used at a dose of 1–2 mg/kg/day of prednisone (or equivalent), in patients with severe systemic
symptoms (e.g., life-threatening internal organ involvement) in conjunction with their cutaneous eruption; a slow taper is necessary, often
requiring weeks to months.37 For patients with SJS/TEN, intravenous immunoglobulin or cyclosporine has been used.38
Provide symptomatic therapy for patients with drug-induced skin lesions. After discontinuation of the offending medication, most drug-
induced cutaneous eruptions will resolve in 5–7 days. In patients with serious drug-induced reactions, symptoms generally begin to abate
within days, but this may vary from weeks to months. Many patients require further assessment; some patients may require a change in
therapy, drug testing or follow up (e.g., liver function tests). Any patient who has a fever or other accompanying symptoms such as malaise
should be assessed by an appropriate healthcare practitioner.

Provide the patient with information regarding the adverse drug reaction. This includes the drug involved in the reaction (if known), the
patient's predisposition to possible recurrence on exposure to the drug, potential cross-reaction to other drugs (e.g., ASA and NSAIDs) and
genetic predisposition of family members, if applicable. No genetic basis has been found for most adverse drug reactions, including
penicillin-allergic reactions. However, for serious reactions such as DRESS, serum sickness-like reactions to cefaclor and serious
dermatologic reactions (e.g., SJS and TEN), the risk in first-degree relatives of patients who have had reactions is substantially higher, and
counselling family members is a crucial part of the management process. Studies have shown that genetic susceptibility may also increase
the risk of developing SJS/TEN. In a Han Chinese population, HLA-B*1502 and HLA-A*3101 were strongly associated with carbamazepine-
induced Stevens-Johnson syndrome.39 In response to these studies, the US Food and Drug Administration (FDA) and Health Canada
recommend genetic screening for patients of Asian ancestry before initiation of carbamazepine therapy, and avoidance of carbamazepine in
patients who test positive.40 In addition, advise the patient to enroll in the Medic Alert program.
Algorithms
Figure 1: Assessment of Patients with Possible Drug-induced Skin Reactions

a
Examples of underlying diseases include infectious mononucleosis (ampicillin-related reactions), HIV (sulfamethoxazole/trimethoprim), and
infectious etiologies, e.g., viral skin rash, bacterial infections.
b See Viral Skin Rashes.
c See Prevention and Treatment of Sun-induced Skin Damage.
d At this point perform a literature search to determine whether this reaction has been reported in association with this drug.
Drug Table
Table 4: Therapy for Drug-induced Skin Reactions
Analgesics acetaminophen 325–1000 mg Q4–6H po Hepatotoxicity: Acetaminophen Useful for $
Atasol SR: 650 mg Q8H po Increased risk in has been treatment of
Preparations, (maximum 4 g/day) malnourished reported to mild to
Tempra, Tylenol, patients, those increase INR in moderate
Tylenol Children's, with excessive warfarin-treated phototoxic
generics alcohol intake patients. Check reactions
(>3 drinks per INR if that can be
day) or pre- acetaminophen managed as
existing hepatic ≥2 g/day is used for ordinary
disease. Baseline for ≥3 sunburn.
LFTs should be consecutive days. Avoid ASA
measured in Adjust warfarin and NSAIDs
high-risk dosage as in urticarial
patients. required. lesions.
Phenytoin,
barbiturates,
carbamazepine
may increase
acetaminophen
metabolism and
formation of toxic
metabolite, thus
increase risk of
hepatotoxicity;
risk may be
increased in
patients taking
high therapeutic
doses of
acetaminophen
and antiepileptic
drugs chronically.
Analgesics ibuprofen 200–400 mg Q6–8H po; Local GI effects Warfarin Useful for $
Advil, Advil maximum dose for self- (dyspepsia, (increased treatment of
Children/Pediatric, care: 1200 mg/day diarrhea), GI bleeding risk via mild to
Advil Junior complications antiplatelet moderate
Strength, Advil (ulceration/upper effects and GI phototoxic
Liquid Gels, GI bleed); complications); reactions
Motrin, Motrin exacerbation of monitor INR more that can be
(Children's), HF, acute renal frequently during managed as
Motrin IB, Motrin failure. initial period after for ordinary
Liquid Gels, Increased LFTs: NSAID started sunburn.
generics Transient; and watch for Avoid ASA
hepatotoxicity is signs of bleeding. and NSAIDs
rare; more likely Increased lithium in urticarial
to occur in levels—monitor. lesions.
patients with pre- Methotrexate—
existing hepatic NSAIDs inhibit
disease or in the renal
patients with elimination of
excessive MTX. Avoid
alcohol intake NSAIDs in people
(>3 drinks per using high dose
day). MTX (e.g.,
cancer). For
people using
intermittent low-
dose MTX for
arthritis, risk is
minimal.
Antihypertensives
(e.g., beta-
blockers,
diuretics, ACEI):
may decrease
antihypertensive
effects; measure
baseline BP,
remeasure 1–2
wk after starting
NSAID and adjust
antihypertensive
therapy as
required.
Increased risk of
GI bleed with
SSRIs.
Increased risk of
GI adverse
effects with
alcohol.
Give 30 min after
or 8 h before low-
dose ASA.
Analgesics naproxen sodium 220–440 mg/day po in 1 Local GI effects Warfarin Useful for $
Aleve, Maxidol, or 2 divided doses; (dyspepsia, (increased treatment of
generics maximum dose for self- diarrhea), GI bleeding risk via mild to
care: 440 mg/day complications antiplatelet moderate
(ulceration/upper effects and GI phototoxic
GI bleed); complications); reactions
exacerbation of monitor INR more that can be
HF, acute renal frequently during managed as
failure. initial period after for ordinary
Increased LFTs: NSAID started sunburn.
Transient; and watch for Avoid ASA
hepatotoxicity is signs of bleeding. and NSAIDs
rare; more likely Increased lithium in urticarial
to occur in levels—monitor. lesions.
patients with pre- Methotrexate—
existing hepatic NSAIDs inhibit
disease or in the renal
patients with elimination of
excessive MTX. Avoid
alcohol intake NSAIDs in people
(>3 drinks per using high dose
day). MTX (e.g.,
cancer). For
people using
intermittent low-
dose MTX for
arthritis, risk is
minimal.
Antihypertensives
(e.g., beta-
blockers,
diuretics, ACEI):
may decrease
antihypertensive
effects; measure
baseline BP,
remeasure 1–2
wk after starting
NSAID and adjust
antihypertensive
therapy as
required.
Increased risk of
GI bleed with
SSRIs.
Increased risk of
GI adverse
effects with
alcohol.
Give 30 min after
or 8 h before low-
dose ASA.
Antihistamines, cetirizine Adults and children >12 Minimal to no Increased CNS Patients $
H1 antagonists Reactine, generics y: 5–10 anticholinergic or depression: whose
mg/day; maximum 20 CNS effects; alcohol, symptoms
mg/day however, may sedatives, do not
Children: cause tranquilizers, improve
6–12 y: 5–10 mg/day drowsiness in barbiturates. within 5–7
2–5 y:2.5–5 mg/day some individuals Increased days require
12–23 months:2.5 mg especially at anticholinergic further
once daily; maximum higher doses. side effects: assessment
2.5 mg BID Headache. TCAs, and/or
6–11 months: 0.25 mg/kg scopolamine. treatment.
Q12H
Antihistamines, diphenhydramine Adults and children ≥12 y: CNS: Sedation, Increased CNS Use with $
H1 antagonists Benadryl 25–50 mg Q4–6H po; fatigue, depression: caution in
Preparations, maximum 300 mg/day dizziness, alcohol, the elderly
generics Children: impairment of sedatives, as they may
6–11 y: 12.5–25 mg cognition and tranquilizers, be more
Q4–6H; maximum performance (the barbiturates. susceptible
150 mg/day patient may be Increased to side
2–5 y: 6.25 mg Q4–6H unaware of anticholinergic effects such
maximum 37.5 mg/day impairment). side effects: as sedation
Anticholinergic: TCAs, and
Dryness of the scopolamine. syncope.
mouth and eyes, May increase Avoid in
constipation, levels of CYP2D6 patients with
inhibition of substrates, e.g., angle-
micturition, metoprolol, closure
potential venlafaxine. glaucoma
precipitation of (increased
angle-closure IOP), urinary
glaucoma, obstruction
thickening of (prostatic
bronchial hypertrophy),
secretions. bladder neck
obstruction
(can cause
urinary
retention), GI
obstruction.
Observe
infants and
young
children for
paradoxical
excitation.
Patients
whose
symptoms
do not
improve
within 5–7
days require
further
assessment
and/or
treatment.
Antihistamines, loratadine Adults and children ≥10 y Minimal to no QTc prolongation Patients $
H1 antagonists Claritin, Claritin (>30 kg): 10 mg once anticholinergic or reported with whose
Liquid Capsules, daily CNS effects. concomitant use symptoms
generics Children 2–9 y (≤30 kg): Headache. of loratadine and do not
5 mg once daily amiodarone. improve
Caution is within 5–7
advised. days require
further
P-gp inhibitors
assessment
(e.g.,
and/or
erythromycin,
treatment.
ketoconazole)
may increase
loratadine levels
while P-gp
inducers (e.g.,
carbamazepine,
dexamethasone)
may decrease
loratadine levels;
clinical effect
probably minimal.
Antiseptic hydrogen peroxide Mix half-and-half with Well tolerated. No clinically Useful for $
water and gargle then significant drug oral lesions.
spit, PRN interactions.
Astringents calamine lotion Apply generously PRN Well tolerated. No clinically Store in $
generics significant drug refrigerator
interactions. as physical
cooling
enhances
antipruritic
effect.
Astringents zinc oxide Apply generously PRN Well tolerated. No clinically Store in $
cream/paste significant drug refrigerator
Zincofax, generics interactions. as physical
cooling
enhances
antipruritic
effect.
Bath emollients colloidal oatmeal Add to bath water PRN Well tolerated. No clinically Apply $
Aveeno Oatmeal significant drug unscented
Bath interactions. moisture
cream or
white
petrolatum
to the skin
while it is
still slightly
damp to
avoid water
evaporation.
Counterirritants menthol- or 0.25–5% in various bases: May occasionally No clinically Provide a $

camphor- apply PRN be irritating. significant drug cooling
containing salves interactions. sensation on
Rub A–535, others the skin.
Store in
refrigerator
as physical
cooling
enhances
their effect.
Corticosteroids, prednisone 1–2 mg/kg/day po × 7– Acne, glucose Clearance may Only used $
systemic generics 10 days intolerance, decrease with for select
May need to continue for weight gain, estrogens; may patients with
longer time periods if mood swings increase digitalis systemic
symptoms reoccur and agitation, toxicity symptoms in
cataracts, secondary to association
myopathy, hypokalemia. with a
hypertension, Phenobarbital, cutaneous
osteoporosis, phenytoin, and eruption
aseptic necrosis rifampin may (e.g.,
of large joints, increase DRESS).
adrenal metabolism
suppression, which may
increased necessitate
susceptibility to increased
infection maintenance
dose. Increased
risk of
hypokalemia with
coadministration
of diuretics.
Corticosteroids, hydrocortisone Apply sparingly with Striae, No clinically Cream: $
topical 0.5%, 1% gentle massage BID–QID telangiectasia, significant drug useful in
Cortate, Emo-Cort, PRN atrophy, purpura. interactions. moist areas
Prevex HC, More potent products (due to
generics may be used in areas possible
other than face or folds if drying
required effect).
Ointment:
preferred for
dry or scaly
lesions.
Lotion:
useful for
scalp and
other hairy
areas or for
application
to large body
areas.
Patients
whose
symptoms
do not
improve
within 5–7
days require
further
assessment
and/or
treatment.
Emollients emollients (e.g., Apply generously PRN Possible No clinically After $

unscented temporary significant drug bathing,
moisture creams stinging on interactions. apply
or white application. unscented
petrolatum) moisture
cream or
white
petrolatum
to the skin
while it is
still slightly
damp to
avoid water
evaporation.
Useful for
treatment of
mild to
moderate
phototoxic
reactions
that can be
managed as
for ordinary
sunburn.
a
Cost of 1 dose or 30 g of cream unless otherwise specified; includes drug cost only.
b
For information on other antihistamines, see Allergic Rhinitis.
c
For information on other topical corticosteroids, consult the Compendium of Therapeutic Choices: Atopic Dermatitis.
d For more information on emollients, see Dry Skin.
Abbreviations: ACEI = angiotension converting enzyme inhibitors; CNS = central nervous system; CYP = cytochrome P450; GI = gastrointestinal; IOP =
intraocular pressure; MTX = methotrexate
Legend: $ <$3
Suggested Readings
Cotliar J. Approach to the patient with a suspected drug eruption. Semin Cutan Med Surg 2007;26:147-54.
Mockenhaupt M. Severe drug-induced skin reactions: clinical pattern, diagnostics and therapy. J Dtsch Dermatol Ges 2009;7:142-60.
References
Dry Skin

Pathophysiology
The skin and its appendages (e.g., sweat glands, sebaceous glands, hair follicles) serve several important
functions. They protect against minor injury, help control body temperature and water loss, prevent invasion
by microorganisms and prevent radiation damage from sun exposure. The skin is composed of 3 main
layers: epidermis (which includes the stratum corneum), dermis and subcutaneous1 (Figure 1). The stratum
corneum is the upper layer of the skin and acts as the main barrier to water loss and protects from foreign
material. The stratum corneum is composed of dead cells, corneocytes and intercellular lipids. The lipid
component consists of ceramides, cholesterol and free fatty acids. Ceramides are found in high
concentrations in healthy skin and act as a barrier to protect the skin and to maintain hydration.2
If the skin barrier is compromised there is an increase in transepidermal water loss (TEWL) and a decrease
in ceramides and other lipids in the skin. Research in the treatment of dry skin conditions focusses on the
effects of TEWL and decreased ceramide content.3
The term “dry skin” (also known as xeroderma or xerosis) is commonly used to describe skin that may be
rough to the touch and have mild scaling, flaking or peeling of the upper layers, and is often very itchy, with
possible cracking if severe enough.4 Dry skin most often affects the skin of the thighs, lower legs, sides of
the abdomen and the arms. The incidence of dry skin increases with age but can occur at any age
depending on skin type, environmental factors, medical conditions and chronic skin conditions.4 Dry skin is
not related to lack of oils in the skin but rather to water loss from the skin's surface. Dry skin has many
potential causes, some of which are listed in Table 1.
Figure 1: The Skin
Goals of Therapy
Alleviate the unpleasant feel of rough, scaly skin
Restore skin hydration and reduce transepidermal water loss
Facilitate repair of the barrier function and maintain the integrity of the stratum corneum
Relieve itching associated with dry skin
Educate the patient on self-treatment to prevent further damage
Patient Assessment
Dry skin is generally managed with nonprescription therapy by improving skin hydration and addressing any
contributing factors if possible (see Table 1).
Assessment should differentiate between dry skin and other skin conditions (e.g., atopic dermatitis,
psoriasis, fungal infections). Patients require further assessment and/or treatment if the condition does not
respond to initial treatment for dry skin. Treatment failure may indicate an underlying medical disease or
condition. An approach to the patient with concerns about dry skin is presented in Figure 2.
5,6,7,8,9,10,11
Table 1: Factors Contributing to Dry Skin
Genetic abnormalities in keratocyte composition or function (e.g., ichthyosis)
Bathing or showering in hot water too frequently or for long periods of time.
Swimming in chlorinated pools
Use of harsh (alkaline pH), perfumed, deodorant or antibacterial soaps
Over-exposure to sun (e.g., photoaging)
Normal skin aging (decreased activity in the sebaceous and sweat glands)
Low humidity (e.g., cold/windy or very hot climates, electric heat, fireplaces, air conditioning,
recycled air in airplanes)
Medical conditions (e.g., hypothyroidism, chronic renal failure, diabetes, liver disease)
Exposure to UV radiation (e.g., sun) or chemicals
Abrasion
Certain skin conditions (e.g., atopic dermatitis, acne, psoriasis)
Medications known to cause dry skin (e.g., anticholinergics, chemotherapy agents, niacin, systemic
retinoids, vitamin A)
Several self-care measures will reduce the feeling of dry, rough skin.4,5,11,12 Offer the following advice:
Avoid excessive bathing or long baths or showers; have brief 3- to 5-minute baths or showers 2–3
times per week; take sponge baths using warm water to maintain hydration
Use tepid rather than hot water while bathing or showering
Avoid harsh or perfumed soaps; limit the use of soaps; use soap that is mild and nonperfumed or use a
mild cleanser with a pH close to skin pH (slightly acidic)
Pat the skin dry (rather than rubbing vigorously) after bathing
Add bath products at the end of a bath or after a bath. Skin hydration is increased if bath products are
added after a bath or applied directly to damp skin and gently patted dry. Bath oils can be added to the
bath, but there is increased risk of slipping, particularly in older persons
Apply a moisturizer after bathing (see Table 2); apply while the skin is still damp (within 3 minutes after
bathing); apply several times a day (3–4 times daily)
Avoid licking dry lips as this can further irritate the lips or worsen the condition. Apply a lip balm
frequently for dry, chapped lips
Increase humidity indoors. Cool mist humidifiers increase the humidity indoors and will minimize water
evaporation from the skin. Humidity should be between 40% and 50% in winter (30% in summer)
Wear gloves, face masks and scarves when outdoors in cold or windy weather to protect the skin from
the drying effects of cold and wind
Avoid wool clothing that may be irritating to the skin. Cotton clothing next to the skin is less irritating
Avoid caffeine, spices and alcohol, which may contribute to dehydration if ingested in large quantities
or used on a regular basis
Avoid swimming in chlorinated pools
Avoid products that contain ingredients that may sensitize the skin (e.g., lanolin, propylene glycol,
fragrances, vitamin E, aloe vera), particuarly in those with with very sensitive skin or in the elderly
Maintain adequate fluid intake from food and water.13
Ailments—Skin Care Products: Dermatitis and Dry Skin, First Aid.
Therapeutic moisturizers should be noncomedogenic, nonirritant and hypoallergenic. Moisturizing agents

include occlusives, humectants, emollients, bath products and barrier repair agents. The value of herbal
products (e.g., aloe vera) as moisturizers is unclear and they may cause skin sensitization. Emollient
ointments act as a barrier and minimize water loss.5,6 They have longer lasting effects than creams or
lotions, but are greasy and not ideal for use on the face. Creams and lotions are more cosmetically
appealing and easier to spread, but their duration of effect is shorter than ointments.4,12 Lotions are
generally oil-in-water emulsions and easier to spread than creams. To enhance adherence, consider patient
preference when selecting a product. Sunscreens are now added to many moisturizing agents to prevent
sun-induced skin damage. Information on moisturizer ingredients can also be found in Table 2.
Short-term use of low-potency topical corticosteroids in addition to emollients, is recommended by some

experts for dry skin that is extremely red, inflamed and swollen. This is used as a temporary measure only.
Once the inflammation improves, the topical corticosteroids are stopped and the emollients continued.8
5,6,14
Table 2: Moisturizer Ingredients for Dry Skin
Type Action Examples Comments
Occlusives Physically block Beeswax, dimethicone, Petrolatum is not
surface of stratum lanolin, mineral oil, paraffin, cosmetically appealing
corneum to prevent petrolatum, soybean oil, (greasy, difficult to spread
further water loss, zinc oxide and remove).
which promotes Lanolin may cause contact
barrier repair. dermatitis: avoid in patients
Minimizes water with sensitive skin.
loss to the external
environment. Occlusives are generally not
well tolerated on facial skin
or in hot, humid climates
due to their greasy nature.
Silicones often found in “oil-
free” products. To avoid the
greasy feel of silicone
products, warm the product
in the hand, use a thin layer
and rub in gently but well.
Apply TID–QID or more
often if required.
Humectants Draw water from Alpha-hydroxy acid (AHA), Used in combination with
the dermis to the glycerin, glycolic acid, lactic occlusives they will enhance
epidermis and from acid, propylene glycol, water holding ability of the
the environment sodium hyaluronate, skin.
(providing humidity sorbitol, urea Glycerin in high
is 70–80%) into the concentrations may
stratum corneum. increase water loss by
Retain water drawing water away from
already present. the skin and may be
irritating. Should not be used
alone, or in those with
sensitive skin.
Lactic acid (>12%) and urea
(>10%) are keratolytic and
used for treatment of more
severe skin conditions.
Lower concentrations are
recommended as
moisturizing agents (lactic
acid ≤12% and urea ≤10%).
Urea may cause stinging
and burning on open skin in
any concentration. Apply
BID–TID PRN.
Emollients Fill the spaces Castor oil, cocoa butter, Combining with emulsifiers
between cells in the ceramides, coconut oil, (stearic acid, stearyl alcohol,
stratum corneum, fatty acids, lanolin, lipids, cetyl alcohol) may improve
sealing moisture mineral oil, palm oil, the oil/water balance of the
into the skin which vitamins A and E, wool fat product.
makes it feel May be combined with
smoother and occlusives to decrease
softer. water loss.
Apply TID–QID PRN.
Bath oils Provide a layer of oil Coal tar, colloidal oatmeal, Best applied at the end of
on the skin that liquid paraffin the bath or shower or
prevents moisture immediately after using a
evaporation. wet compress.
Safety hazard if added to
bath water (increased
chance of slipping).
Colloidal oatmeal relieves
itching and enhances the
barrier function of the skin.
Barrier Normalize skin Ceramides/cholesterol/free Nonsteroidal barrier repair

repair barrier by replacing fatty acids combinations cream.
agents ceramides; Used to treat dry skin and
decreasing associated pruritus in
transepidermal atopic, irritant and radiation
water loss (TEWL); dermatitis.
decreasing triggers
for inflammation.
Mild to moderate dry skin can be self-managed by patients educated on nonpharmacologic methods of
treatment and prevention. The patient should monitor the skin daily for 7–10 days after starting treatment
for improvement in symptoms, and seek medical attention if the condition worsens or shows no
improvement.
Table 3 provides a plan for monitoring therapy for dry skin.
Table 3: Monitoring of Therapy for Dry Skin

Rough, scaly skin Monitor daily for 7–10 days Skin feels If irritation worsens,
for signs of improvement with smoother, no consider allergy to
treatment (moisturizers or longer red, rough or moisturizer ingredient
nonpharmacologic methods). irritated. and discontinue.
Itching Monitor daily for 7–10 days Itching has If itching increases or
for decrease in symptoms decreased or is does not decrease in
with treatment (moisturizers controlled (no severity, consider the
or nonpharmacologic scratching, redness addition of a second
methods). or signs of moisturizer from a
Monitor for signs of infection infection). different group.
if scratching has caused open Signs of infection
areas. (pus, pain, redness)
require further
assessment and/or
treatment.
Dry, flaky skin Monitor daily while using Dry, flaky skin has If skin continues to be
moisturizing products. decreased or skin dry and flaky, consider
Monitor for signs of is soft and alternative treatment.
improvement. hydrated.
Algorithms
Figure 2: Assessment of Patients with Dry Skin
Suggested Readings
Green L. Emollient therapy for dry and inflammatory skin conditions. Nurs Stand 2011;26:39-46.
Guenther L, Lynde CW, Andriessen A et al. Pathway to dry skin prevention and treatment. J Cutan Med Surg
2012;16:23-31.
Reddy M. Skin and wound care: important considerations in the older adult. Adv Skin Wound Care
2008;21:424-36.
References
1. Bond CA. Skin disorders. In: Koda-Kimble MA, Young LY, eds. Applied therapeutics: the clinical use of
drugs. 5th ed. Vancouver: Applied Therapeutics; 1992. p. 64-1-6.
2. Novotny J, Hrabalek, A, Vavrova K. Synthesis and structure-activity relationships of skin ceramides.
Curr Med Chem 2010;17:2301-24.
3. Bikowski J. Case studies assessing a new skin barrier repair cream for the treatment of atopic
dermatitis. J Drugs Dermatol 2009;8:1037-41.
4. Reddy M. Skin and wound care: important considerations in the older adult. Adv Skin Wound Care
2008;21:424-36.
5. Proksch E. The role of emollients in the management of diseases with chronic dry skin. Skin
Pharmacol Physiol 2008;21:75-80.
6. Fitzpatrick TB, Bernhard JD, Cropley TG. The structure of skin lesions and fundamentals of
diagnosis. In: Freedberg IM, Fitzpatrick TB et al., eds. Fitzpatrick's dermatology in general medicine.
5th ed. New York: McGraw-Hill; 1999. p. 155-64.
7. Lynde CB, Kraft JN, Lynde CW. Skin care as an adjunct treatment for skin disease. Skin Therapy Lett
2007;2:1-8. Available from: www.skinpharmacies.ca/2_1_en.pdf. Accessed April 13, 2016.
8. Guenther L, Lynde CW, Andriessen A et al. Pathway to dry skin prevention and treatment. J Cutan
Med Surg 2012;16:23-31.
9. Hurlow H, Bliss DZ. Dry skin in older adults. Geriatr Nurs 2011;32:257-62.
10. Andriessen A. Prevention, recognition and treatment of dry skin conditions. Br J Nurs 2013;22:26-30.
11. White-Chu EF, Reddy M. Dry skin in the elderly: complexities of a common problem. Clin Dermatol
2011;29:37-42.
12. Butler N. National guidelines at a glance: atopic eczema. SA Pharmaceutical Journal June 2009:32-7.
13. Popkin BM, D'Anci KE, Rosenberg IH. Water, hydration, and health. Nutr Rev 2010;68:439-58.
14. Wan DC, Wong VW, Longaker MT et al. Moisturizing different racial skin types. J Clin Aesthet
Dermatol 2014;7:25-32.

Dry Skin
Frostbite

Pathophysiology
Frostbite refers to acute freezing of the tissue caused by temperatures below the freezing point of intact
skin. Frostbite is caused by formation of ice crystals in the tissue, leading to tissue damage.1,2 Formation of
extracellular, and later intracellular, ice crystals results in cellular dehydration and physical damage to cell
membranes and vascular structures. This leads to progressive microvascular collapse and initiates a series
of events that in serious frostbite leads to progressive ischemia, thrombosis and tissue necrosis.3,4 The
severity of injury and degree of irreversible damage is related to the duration of exposure and length of time
the tissue remains frozen, rather than solely to air temperature.
Factors that increase the risk of frostbite include:1,3,5
Wind, high humidity and temperatures below –3ºC

Drug use: Alcohol and sedatives dull mental awareness of cold and impair judgment that would
prevent exposure to cold. Alcohol also inhibits shivering and causes vasodilation. Medications with
sedative or muscle relaxing effects may inhibit shivering and increase the risk of frostbite
General: Psychiatric illness, vagrancy, inadequate or constrictive clothing, previous history of cold
injury, and immobilization may increase the risk of frostbite. Infants have a higher ratio of body surface
area to mass and the elderly have a decreased capacity for metabolic heat production and
vasoconstriction; therefore, they are at higher risk of developing frostbite
Neurologic conditions: Peripheral neuropathy, hypothalamic disease and spinal cord damage may lead
to impairment of cutaneous vasoconstriction
Cardiovascular conditions: Peripheral vascular disease, vascular disease and nicotine use are
predisposing factors for frostbite
Endocrine conditions: Hypothyroidism, hypoglycemia and adrenal insufficiency can increase the risk of
frostbite by decreasing metabolic heat production. Diabetic neuropathy may impair cold awareness.
Frostbite most often affects the hands, fingers, feet, toes, nose, cheeks and ears.3,4 It is difficult to assess
the severity of frostbite while the skin is still frozen as all frozen tissue is hard, pale and numb. Classification
of frostbite is based on rewarmed/thawed tissue. Different degrees of frostbite can occur within different
parts of the same extremity.6,7 The full extent of injury may not be apparent for days after the freezing
episode. Close observation during this time is warranted.8
Frostnip is a superficial nonfreezing injury in which cooling of tissues to less than 10°C results in a blue-
white discoloration of skin, loss of sensation and transient numbness and tingling. Ice crystals (appearing
as frost) form on the surface of the cheeks, ears or nose. Symptoms resolve quickly with rewarming
(covering with clothing, breathing on the affected area and moving to a warmer location). There may be
erythema and mild edema, but there is no tissue damage.2,4,9,10
First-degree frostbite involves partial-thickness skin freezing and presents with a numb central white plaque
with peripheral erythema. There may be mild edema, but no blistering. Second-degree frostbite involves full
thickness skin freezing and presents with significant edema with erythema and large blisters filled with a
clear or milky fluid appearing within 24–48 hours. The skin under the blisters remains soft and perfused.
The affected area generally remains sensitive to heat and cold.2,6,9,11,12
In third-degree frostbite there is skin and subcutaneous tissue freezing with tissue necrosis. The affected
area may appear deep purple or red with dark, hemorrhagic blisters that turn into a hard black eschar (scab)
over 2 weeks. Fourth-degree frostbite involves deep tissue necrosis extending to the level of muscle and
bone. It presents with the affected area being cold and waxy, firm and numb (even after rewarming) with
deep red, mottled skin which eventually becomes gangrenous.6,9,11,12 The most serious injuries result in
mummification and autoamputation at 22–45 days.3,4
First- and second-degree frostbite are generally considered superficial frostbite in that minimal or no tissue
damage is anticipated. Third- and fourth-degree frostbite are considered deep frostbite and tissue loss is
anticipated.9,12
Long-term sequelae of frostbite can include tingling and burning sensations from ischemic neuritis lasting
for weeks. Cold sensitivity, loss of sensation, pigmentation changes, nail deformities or hyperhidrosis may
persist for years.3,10
Two other cold-related injuries that do not involve freezing are chilblains (also known as pernio or perniosis)
from repetitive exposure to mild, dry cold, and trench foot from prolonged exposure to wet cold.10 In
chilblains, persistent vasospasm and vasculitis results in pruritus, redness and mild edema of the face,
hands, feet and shins, which can progress to the development of plaques, bluish nodules and ulceration. In
trench foot, neurovascular damage occurs in the absence of ice crystal formation. Feet initially appear pale
and cyanotic, and feel cold, numb and tingly. After rewarming, the skin remains very painful to touch, and
blisters are common and may ulcerate. Pain, cold sensitivity and hyperhidrosis may last for years.10
Goals of Therapy
Identify associated hypothermia and prevent further heat loss
Minimize tissue damage during rewarming
Control pain
Prevent infection in damaged tissues
Patient Assessment
All patients with suspected frostbite should also be assessed for symptoms of hypothermia such as
shivering (although this decreases as hypothermia worsens), dizziness, hunger, nausea, slurred speech or
mumbling, confusion, irrational behaviour and drowsiness. If hypothermia is suspected, urgent medical care
is required. For further discussion of hypothermia, consult the Compendium of Therapeutic Choices:
Thermoregulatory Disorders in Adults.
Except in the case of mild (first-degree) frostbite (affected area is pink, warm, has no blisters after thawing
and pain is controlled with nonprescription analgesics), emergency hospital care for all patients is preferred
for the following reasons:6,7,12
severity of the injury is difficult to assess while tissue is still frozen; proper rewarming and post-
warming assessment is required
full extent of the injury may not become apparent for several days and may be more severe than the
original appearance suggested; close observation is recommended during this time
some treatment options for severe frostbite (e.g., thrombolytics, vasodilators) should be instituted
within 24 hours of injury.
If immediate referral is not possible, provide instructions for rewarming if appropriate, and observation (see
Nonpharmacologic Therapy). Assessment of patients with frostbite is presented in Figure 1.
Prevention
Frostbite and related cold injuries can generally be prevented with planning prior to exposure to the cold.
Ensuring adequate tissue perfusion and minimizing heat loss are the main components of frostbite
prevention.
Measures to reduce the risk of frostbite include:9,13

maintaining adequate hydration and nutrition
minimizing restriction in blood flow by avoiding immobility or constrictive clothing or footwear
avoiding environmental conditions below –15°C, even with low wind speeds
dressing appropriately; wear a warm hat and heavy warm mittens (preferred over gloves), increase
insulation by layering clothes appropriately, choose synthetic fabrics, fleece, silk or wool blends, and
avoid cotton as it retains moisture
avoiding perspiration or wet extremities (keep hands and feet dry)
avoiding drugs or alcohol as they may impair awareness of changing physical and environmental
conditions
using chemical hand and foot warmers (these must not be placed directly against the skin or constrict
blood flow in any way)
recognizing frostnip or superficial frostbite before it progresses: an extremity at risk of frostbite (e.g.,
numb, poor dexterity, pale colour) should be warmed in the axilla or on the abdomen
minimizing duration of exposure to cold
using caution while exercising; it can increase core and peripheral temperatures and perfusion, but can
also lead to exhaustion and collapse
applying emollients on the skin is not preventive and may even increase risk of frostbite.
Until emergency medical care is available, the following first aid measures can be undertaken:2,3,9,10
move the patient to a warm location as soon as possible. Unless absolutely necessary, the person
should not walk on frostbitten toes or feet
do not thaw the area if there is any risk of refreezing, which can worsen tissue damage
remove jewelry or constrictive clothing from the affected area
do not rub the area (even to dry it) as friction can increase tissue damage
remove wet clothing once the patient is in a warm environment
institute passive rewarming (warm environment, blankets, tucking affected area into armpit, groin or
against abdomen) until active rewarming can be started. If active rewarming cannot be undertaken,
allow passive thawing to occur
institute rapid active rewarming as soon as possible by immersing in warm water (40–42°C;
comfortably warm bath) for 15–30 minutes until the skin feels soft and pliable and appears red
after rewarming, elevate the affected area to minimize edema
fingers and toes may be separated by dry sterile dressings/gauze
ensure the patient is adequately hydrated
if blisters develop, leave them intact to decrease risk of infection, unless they are restricting range of
motion
if blisters rupture, cover with clean dry gauze until emergency medical care is available
patients should not smoke as nicotine may cause vasoconstriction and reduce blood flow.
Frostnip responds quickly to rewarming with no sequelae.4,10 Chilblains are treated conservatively with
warmth, elevation of the area and application of soothing moisturizers.4 Trench foot is treated by rewarming
the skin, elevating the area and wrapping the patient in loose, soft material to maintain constant warmth.
Ailments—Analgesic Products: Internal Analgesics and Antipyretics; Skin Products: First Aid.
Frostbitten areas may become very painful during the rewarming process. Adequate pain relief should be
provided. NSAIDs (e.g., ibuprofen, naproxen sodium) are recommended; by decreasing production of
prostaglandins and thromboxanes (which can cause vasoconstriction and therefore worsen dermal
ischemia), they may prevent further tissue damage in addition to relieving pain.1,3,9 Some guidelines
recommend the routine use of ibuprofen at a dose of 12 mg/kg/day divided BID for its prostaglandin
inhibitory effects (even in the absence of pain).9 [Evidence: SORT C] Acetaminophen can be used to relieve
pain for patients unable to take NSAIDs.2 In serious frostbite, opioid analgesics may be required for pain not
responding adequately to nonprescription analgesics.
Limited observational evidence shows aloe vera may improve frostbite outcomes by reducing prostaglandin
and thromboxane formation in more serious frostbite where blisters have formed.14 Although it does not
penetrate far into tissue and may be beneficial only for superficial areas, some guidelines recommend aloe
vera gel be applied to thawed tissue at each dressing change or Q6H despite the limited evidence, as the
risks associated with its use are low.9 A systematic review showed there is inconclusive evidence regarding
whether aloe vera gel or dressings improve healing in acute or chronic wounds.15
Frostbite injuries are not particularly prone to infection and use of systemic antibiotics for infection
prophylaxis is controversial; however, they are sometimes used in cases of significant tissue loss.1,3
Although evidence is not available regarding effectiveness, some sources recommend topical antibiotics be
applied in cases where blisters have been debrided or have ruptured, as the area may be at a higher risk of
infection.5
Frostbite injuries that include blisters are prone to tetanus and therefore tetanus prophylaxis is indicated.2
Other therapies aimed at increasing tissue perfusion (with varying amounts of evidence to support their use)
may be considered in some patients admitted to hospital. These may include low-molecular-weight
dextran, thrombolytics, vasodilators and pentoxifylline. Other measures that may improve healing include
hydrotherapy and hyperbaric oxygen.7,9,12
Table 1 provides information on monitoring of therapy for frostbite.
Table 1: Monitoring of Therapy for Frostbite

Tissue Monitor continuously Rewarmed tissue will Patients require further

appearance until area has rewarmed be warm, red and assessment and
(Hard, whitish, (15–30 min in warm pliable. It may be treatment if there are
frozen-looking water). swollen. signs of infection (pus,
tissue) Monitor over the next Areas of superficial increased redness,
24–48 h for blistering or frostbite will develop fever, increased pain).
signs of infection. normal colour and If blisters rupture, cover
Monitor for 4–7 days warmth with no blisters with nonadherent
for wound healing and within 24 h. gauze and consider
signs of infection. need for topical
antibiotics.a
Numbness and Monitor for symptoms Symptoms of tingling Patients with

tingling of numbness and and pain are tolerable superficial frostbite
tingling during by patient during with continued
rewarming. rewarming. In numbness and tingling
Monitor for 24–48 h for superficial frostbite, for 24–48 h need
increase in numbness tingling and numbness further assessment
or tingling with subside without and/or treatment as
superficial frostbite. treatment within 24–48 the frostbite may be
h. In deep tissue worse than initially
Monitor for 2–4 weeks frostbite, tingling and thought.
for signs of numbness may persist
improvement or Patients with tingling
for weeks after and numbness longer
worsening of numbness freezing.
or tingling to the area than 2 wk should have
frozen. already been assessed
as the frostbite is likely
deep tissue frostbite.
Pain Monitor pain every 4–6 Pain relief for patient Treat with pain
h for 24 h. during and after the relievers according to
If pain increases or is rewarming process. type of frostbite:
not resolved with Pain relief within 24 h NSAIDs or
nonprescription for superficial frostbite. acetaminophen for
treatment within 24 h superficial frostbite.
treatment with opioid If pain relief has not
analgesics is required. improved with
nonprescription pain
relievers (as in deep
tissue frostbite) further
assessment for
possible treatment with
opioids is necessary.
a Evidence to support use of topical antibiotics in this scenario is lacking; however, they are often used in practice.
Algorithms
Figure 1: Assessment of Patients with Frostbite

Suggested Readings
Health Canada. First Nations and Inuit Health Branch. Clinical Practice Guidelines for Nurses in Primary
Care. Adult care. Chapter 9. Skin. Dermatological emergencies. Frostbite. Available from: www.hc-
sc.gc.ca/fniah-spnia/services/nurs-infirm/clini/adult/skin-peau-eng.php#tc20.
McIntosh SE, Opacic M, Freer L et al. Wilderness Medical Society practice guidelines for the prevention and
treatment of frostbite: 2014 update. Wilderness Environ Med 2014;25:S43-54.
Patel NN, Patel DN. Frostbite. Am J Med 2008;121:765-6.
References
1. Patel NN, Patel DN. Frostbite. Am J Med 2008;121:765-6.

2. Health Canada. First Nations and Inuit Health Branch. Clinical Practice Guidelines for Nurses in
Primary Care. Adult care. Chapter 9. Skin. Dermatological emergencies. Frostbite. Available from:
www.hc-sc.gc.ca/fniah-spnia/services/nurs-infirm/clini/adult/skin-peau-eng.php#tc20. Accessed
March 8, 2016.
3. Murphy JV, Banwell PE, Roberts AH et al. Frostbite: pathogenesis and treatment. J Trauma
2000;48:171-8.
4. Kanzenbach TL, Dexter WW. Cold injuries. Protecting your patients from the dangers of hypothermia
and frostbite. Postgrad Med 1999;105:72-8.
Fungal Nail Infections (Onychomycosis)

Introduction
Onychomycosis is a fungal infection of the nails. It can cause discomfort, pain and disfigurement, resulting
in functional and occupational limitations that can significantly impact quality of life.1 Treatment is
prolonged and reinfection is common.
Pathophysiology
The nail is a specialized outgrowth of skin. The visible hard nail (nail plate) grows from a small area located
in the half-moon white region (nail matrix) near the cuticle (Figure 1). The nail plate grows toward the tip of
the toe or finger and is attached longitudinally to the nail bed. Fungal invasion of the nail matrix can
drastically change the appearance of the nail.
Onychomycosis is estimated to affect 6.5% of the Canadian population, with increasing prevalence in older
individuals.2 It is more common in persons with other nail problems (e.g., psoriasis or trauma), occupations
requiring occlusive footwear, peripheral vascular insufficiency or immunosuppressed states (e.g., diabetes,
HIV infection or immunosuppressive therapy).3,4 In one-third of cases, there is an association with the
presence of tinea pedis (athlete's foot).5,6
Onychomycosis is caused primarily by dermatophytes, occasionally by yeasts (mainly Candida) and rarely by
nondermatophyte moulds. When dermatophytes are the specific cause of the nail infection, this is called
tinea unguium.7 The usual causative dermatophyte is Trichophyton rubrum. Occasionally, other
dermatophytes such as Trichophyton mentagrophytes var interdigitale and Epidermophyton floccosum are
involved.8,9
Onychomycosis is a chronic infectious condition that rarely remits spontaneously and usually progresses to
affect other nails or skin areas. In patients with diabetes or immunosuppression, these infected areas can
serve as a reservoir of fungi that may cause reinfection or serve as a portal of entry for bacteria, leading to
secondary bacterial infections such as cellulitis.10
Onychomycosis is classified into 5 subtypes, which are described in Table 1.
Goals of Therapy
Eradicate or reduce fungal infection
Improve appearance of nail
Prevent spread of fungal infection
Prevent recurrences of fungal infection
Prevent secondary bacterial infections
Figure 1: Anatomy of the Toenail Showing Right Large Toe

Reproduced with permission from Renee L. Cannon, 2001
Patient Assessment
Characteristics and differential diagnosis of onychomycosis can be found in Table 1 and Table 2. Nail
dystrophy has many causes, making diagnosis based on clinical appearance difficult; fungi are responsible
50% of the time. In addition, since treatment of onychomycosis is long term and an extended time period is
needed for the nail to grow out, an accurate diagnosis is necessary. Fingernails take about 6 months to grow
out while toenails take about 12 months. It is necessary to submit a collection of specimens (e.g.,
subungual debris and nail clippings) to a laboratory for culture and microscopy to confirm the diagnosis and
identify the causative fungus.11
Table 1: Characteristics of Onychomycosis Subtypes

Type of Onychomycosis Characteristics Comments
Distal and lateral Thickening and white-to-brown Most common: 90% of cases.
subungual discoloration of the distal and/or Intercurrent tinea pedis is
onychomycosis (DLSO) lateral edge of the nail, with modest or frequent.
no change to the nail's shape. Infected toenails more
The dermatophyte Trichophyton common than fingernails.
rubrum invades the nail bed and the
underside of the nail plate beginning
at the hyponychium, then migrates to
the cuticle/nail matrix.
Crumbling yellow debris (subungual
hyperkeratosis) is usually evident
under the nail edge.
Progressive invasion of the nail plate
causes a worsening dystrophic nail
and onycholysis (nail plate separates
from the nail bed).
Endonyx subungual Infection with Trichophyton Rare and often considered a

onychomycosis soudanense and Trichophyton subtype of DLSO.
violaceum starts from the pulp as in
DLSO, but penetrates the distal nail
plate to form milky white patches and
indentations. There is no involvement
of the nail bed so there is no
subungual hyperkeratosis or
onycholysis.
Proximal subungual Whitening and crumbling begins at the Up to 6% of cases. Most

onychomycosis (PSO) proximal area beneath the nail bed (at common in
the cuticle). immunosuppressed patients;
The infecting dermatophyte often a marker for AIDS.
Trichophyton rubrum enters through
the proximal nail fold and penetrates
the newly formed nail plate, then
migrates distally.
Total dystrophic Nail is thickened, opaque, yellow- Any severe variety of

onychomycosis (TDO) brown and the entire nail plate and onychomycosis can progress
matrix are infected. to the state where the nail
plate is completely destroyed.
Superficial white Surface of the nail has patches that Up to 7% of cases. Children
onychomycosis (SWO) are powdery and white. are more commonly affected.
The dermatophyte Trichophyton
mentagrophytes invades the nail plate
directly from above and does not
involve the nail bed. As the disease
progresses, the entire nail plate can be
involved and the nail becomes
roughened and crumbly.
Yeast onychomycosis Yeast is a common cause of 5% of cases.

onychomycosis of fingernails and, less
frequently, of toenails.
C. albicans is involved in 70% of cases.
Can manifest in several forms.
Chronic Erythematous swelling of the nail fold Affects persons who have
paronychia with secondary onycholysis. occupations requiring
Nail plates become discoloured frequent immersion of hands
(brown or bluish-black). in water.
In severe cases, the digits can appear

to have a bulbous or drumstick
appearance and the entire thickness
of the nail may be involved. Pressure
on and movement of the nail is
painful.
Distal nail Initial subungual hyperkeratosis with a Associated with some forms
candidal yellowish grey mass that lifts off the of peripheral vascular
infection nail plate. This leads to onycholysis. disease.
Chronic Can lead to gross thickening of the Associated with

mucocutaneous nails (amounting to a candida immunosuppressed states.
candidiasis granuloma) and additional
involvement of mucous membranes.
Candida invades the entire thickness
of the nail into the nail plate to cause
brittle nails.
Secondary Severe pre-existing dystrophic Occurs in nails damaged from

candidal changes to the nail are worsened trauma or diseases such as
onychomycosis when candida invades the nail plate psoriasis.
and nail bed. Clinical signs vary.
Table 2: Differential Diagnosis of Fungal Nail Infections

Differential Diagnosis to Clinical Features
Consider
Bacterial paronychia Painful red swollen area of the nail fold or cuticle which occurs
suddenly in contrast to the slow onset seen with candidal
paronychia. Bacterial paronychia is often also associated with
pus-filled vesicles.
Drugs, e.g., cancer Onycholysis.

chemotherapy, fluoroquinolones,
naproxen, oral contraceptives,
tetracyclines
Eczema Transverse ridges.

Nail folds affected.
History of eczema.
Lichen planus Nails have prominent longitudinal ridges. Nail atrophy. Oral
ulcers, itchy papules on wrists, shins and torso.
Malignant melanoma Vertical pigmented bands form in the nail bed.
Onychogryphosis (senile) Thickened, curved nail (claw-like), often seen in elderly persons
with vascular insufficiency.
Psoriasis Symmetrical nail involvement. Nail pitting and “oil staining”.

Yellow-gray or silvery white nails. Thick, silvery scales on skin
of elbows and knees.
Terminal interphalangeal joint arthritis.
Squamous cell carcinoma Papilloma or warty involvement of paronychia, erosions and

scaling.
Trauma Single nail affected, nail colour change is homogeneous, nail

shape is altered.
Yellow-nail syndrome Nails grow slowly, are yellow-green, thick and curved.
Associated with a defective lymphatic drainage in lungs
causing pulmonary infections.
Persons with onychomycosis should be treated for any associated tinea pedis. Nonpharmacologic
treatments include wearing footwear and cotton socks that minimize humidity, drying feet and interdigital
spaces thoroughly after washing, and avoiding fungal transmission from shared public spaces such as
swimming pools. Nails should be kept clean and cut short. Infected persons should not share nail clippers
or footwear.12 Preventing further trauma to toenails by wearing nonrestrictive footwear or orthotics (which
require fitting) may be helpful. People who have their hands immersed in water for long periods of time can
wear rubber gloves to protect their fingernails. Applying emollients to cracked skin may reduce further entry
points for fungus. Chronic health conditions such as diabetes or peripheral vascular disease that predispose
persons to nail infections should be well controlled.5,13,14 Although nail débridement is sometimes tried,
evidence of its efficacy is lacking.5,15
For further discussion of pharmacologic therapy for fungal nail infections, consult the Compendium of
Therapeutic Choices: Fungal Nail Infections.
Ailments—Skin Care Products: Antifungals.
In 90% of onychomycosis cases, the infecting dermatophyte is T. rubrum and in 80% of cases, toenails are
affected. Most patients have the distal and lateral subungual subtype in which the fungus hides under the
nail plate; therefore, response to topical therapies is not expected unless the formulation allows for
penetration through the nail plate.11,16 Although the evidence is inconsistent, topical therapies may be
useful adjuncts in combination with oral therapy or as prophylaxis to prevent recurrence.
Topical Therapy
Topical agents (e.g., ciclopirox 8%, efinaconazole 10%, propylene glycol 66.4%/urea 20%/lactic acid
10%) are recommended for very early, mild cases of DLSO with only distal involvement, SWO or when
there are contraindications to systemic therapy.11 Cases with involvement of the lunula (crescent-
shaped area at the base of the nail) or onycholysis should not be treated topically. Limited evidence
suggests that topical agents have equally poor cure rates.15,17 Ciclopirox 8% lacquer is applied to the
affected nails once daily for 21 weeks (fingernails) or 48 weeks (toenails). The complete cure rate is 7%
with a relapse rate of 40% three months after finishing treatment.18 Efinaconazole 10% solution is
applied as 2 drops (great toenail) or 1 drop (other toenails) once daily for 48 weeks. The complete cure
rate is 15%.19 The combination product of propylene glycol 66.4%/urea 20%/lactic acid 10% is applied
once daily to the nail and under the tip of the nail for 6 months.20 Although evidence is lacking, filing the
upper surface of the thickened nail (vigorous débridement) may increase the extent of penetration for a
topical preparation and may increase the likelihood for successful topical therapy.13,21
Systemic Therapy
Oral agents for onychomycosis treatment include the allylamine terbinafine and the azole antifungals
fluconazole, itraconazole, ketoconazole and voriconazole. Terbinafine is considered the drug of choice
for dermatophyte onychomycosis based on its higher efficacy, tolerability and lower risk of drug
interactions.11 For candidal onychomycosis, itraconazole is considered first-line treatment based on its
high activity against Candida and shorter treatment course compared with terbinafine.11 Fluconazole
has relatively reduced efficacy and is considered an alternative if there is intolerance to the other
agents.22 Voriconazole is an option only for recalcitrant nail infections as clinical trial data are limited.
There is insufficient evidence to support the use of oral ketoconazole.
Doses and regimens of oral agents shown to be effective for onychomycosis include terbinafine 250 mg
daily and itraconazole 200 mg daily for 12 weeks for toenails and 6 weeks for fingernails. Other
regimens include “pulse dosing” of itraconazole 200 mg twice daily for 1 week per month, or terbinafine
500 mg once daily for 1 week per month, with 2 cycles for fingernails and 3 for toenails.11,23,24,25 These
antifungals are incorporated into the nail plate via the nail matrix and by diffusion from the nail bed. Their
antifungal activity is retained in the nail bed for months after cessation of therapy.26 Four months of
continuous therapy with terbinafine or itraconazole typically results in a 55% or 26% complete cure rate,
respectively.27,28 The relapse rate with either agent is approximately 30%.29 Fluconazole 150–300 mg
once weekly may be effective if used for a duration of 12–16 weeks for fingernail onychomycosis or 18–
26 weeks for toenail onychomycosis.30,31 There is no evidence that continuous or intermittent regimens
produce significantly different cure rates or adverse events.
Chemical or Surgical Avulsion
In unresponsive cases, chemical or surgical avulsion combined with topical ketoconazole 2% cream or
ciclopirox 8% lacquer applied under occlusion with polyethylene wrap may be performed by a podiatrist
or dermatologist.32 Risks associated with nail avulsion include pain, possible wound infection and
scarring.
Laser and Light Therapy
Device-based therapy involving lasers, photodynamic therapy, iontophoresis and ultrasound are
promising alternatives for patients unable or unwilling to use conventional pharmacologic options.
Evidence regarding the efficacy and safety of these techniques is accumulating.33,34
A monitoring plan for patients with onychomycosis is provided in Table 3. Resolution of the fungal infection
takes months, while it can take up to 18 months for the appearance of the nail to return to normal,
particularly in persons with poor circulation. The nail may never appear normal in some cases. Continued
monitoring for recurrence of a nail infection or a concurrent skin infection is important. While the patient is
taking continuous daily doses of itraconazole, liver function tests should be performed at baseline then
monthly.35 Hepatic enzyme elevations double the upper level of normal occur in 4% of patients, at which
time the drug should be discontinued. Monitoring liver function in healthy patients is usually unnecessary
when using terbinafine or pulsed itraconazole regimens for the treatment of onychomycosis. However,
baseline liver function tests and complete blood count are advised in patients with heavy alcohol
consumption, hepatitis or hematological abnormalities.36 If the patient has active or chronic liver disease,
oral antifungals should be avoided.37,38
Table 3: Monitoring of Therapy for Onychomycosis

Symptoms Monitoring Endpoint of Treatment Actions
Measure distance of Patient: Cessation of growth of Further assessment is

outgrowth of disease- Monthly diseased nail (6 wk for required if no
free nail (normal growth Healthcare fingernails, 12 wk for toenails). improvement in nail
rate is practitioner: Normal appearance of nail (at appearance at
1.5–2 mm/month) Every 1–2 12 months) expected endpoint.
months
Fatigue, jaundice, Patient: Absence of symptoms Discontinue oral

anorexia, nausea, Daily antifungal and
vomiting, dark urine or Healthcare perform liver function
pale stools due to oral practitioner: tests.
antifungals Monthly
Paronychia (Candida Patient: No new lesions Treat with topical

albicans) Weekly nonprescription anti-
Healthcare yeast agents
practitioner: (clotrimazole,
Monthly miconazole, nystatin).
Irritation caused by Patient: Little or no irritation that Stop therapy if no

topical agents Daily while subsides with continued use improvement after
on therapy several doses or if
Healthcare severe.
practitioner:
Monthly
Secondary bacterial Patient: No new lesions Further assessment

infections: cellulitis Daily required if signs of
Healthcare pain, swelling, redness
practitioner: or drainage around
Monthly nails.
Suggested Readings
de Berker D. Clinical practice. Fungal nail disease. N Engl J Med 2009;360:2108-16.
Gupta AK, Uro M, Cooper EA. Onychomycosis therapy: past, present, future. J Drugs Dermatol 2010;9:1109-
13.
References
1. Roseeuw D. Achilles foot screening project: preliminary results of patients screened by

dermatologists. J Eur Acad Dermatol Venereol 1999;12:S6-9.
2. Gupta AK, Jain HC, Lynde CW et al. Prevalence and epidemiology of onychomycosis in patients
visiting physicians' offices: a multicenter canadian survey of 15,000 patients. J Am Acad Dermatol
2000;43:244-8.
3. Gupta AK, Konnikov N, MacDonald P et al. Prevalence and epidemiology of toenail onychomycosis in
diabetic subjects: a multicentre survey. Br J Dermatol 1998;139:665-71.
4. Burzykowski T, Molenberghs G, Abeck D et al. High prevalence of foot diseases in Europe: results of
the Achilles Project. Mycoses 2003;46:496-505.
5. Szepietowski JC, Reich A, Garlowska E et al. Factors influencing coexistence of toenail
onychomycosis with tinea pedis and other dermatomycoses: a survey of 2761 patients. Arch
Dermatol 2006;142:1279-84.
6. de Berker D. Clinical practice. Fungal nail disease. N Engl J Med 2009;360:2108-16.
7. Verma S, Heffernan P. Superficial fungal infections. In: Fitzpatrick TB, Wolff K et al., eds. Fitzpatrick's
dermatology in general medicine. 7th ed. New York: McGraw-Hill; 2008.
8. Sigurgeirsson B, Baran R. The prevalence of onychomycosis in the global population: a literature
study. J Eur Acad Dermatol Venereol 2014;28:1480-91.
9. Coleman NW, Fleckman P, Huang JI. Fungal nail infections. J Hand Surg Am 2014;39:985-8.
10. Elewski BE. Onychomycosis. Treatment, quality of life, and economic issues. Am J Clin Dermatol
2000;1:19-26.
11. Ameen M, Lear JT, Madan V et al. British Association of Dermatologists' guidelines for the
management of onychomycosis 2014. Br J Dermatol 2014;171:937-58.
Fungal Skin Infections
Penny F. Miller, BSc(Pharm), MA(Ed)

Peer Review Date: February 2016
Introduction
Superficial fungal infections are very common skin diseases affecting the majority of people at some
point in their lifetime. Numerous fungi are capable of invading the epidermis, hair, nails and mucosa.
Three genera of dermatophytes (Trichophyton, Epidermophyton and Microsporum) and yeastlike fungi,
Candida or Malassezia furfur, are responsible for most infections.1,2 This chapter is divided into 3
sections: Dermatophyte Infections, Yeast Infections: Pityriasis Versicolor (Tinea Versicolor) and Yeast
Infections: Cutaneous Candidiasis. Table 1 provides information on the characteristics and differential
diagnosis of fungal skin infections.
1,3,4,5
Table 1: Characteristics and Differential Diagnosis of Fungal Skin Infections
Condition Distribution Lesions Differential Diagnosis
Infections caused by dermatophytes (see Dermatophyte Infections)a
Tinea Beard Reddened areas Folliculitis (bacterial or candidal): small

Barbae with perifollicular pustules around hair follicles.
papules and Perioral dermatitis: papules and pustules
pustules or surrounding the mouth and chin. Often
swollen, inflamed includes a history of topical steroid use.
mass with pus See Acne.
and hair loss.
Acne vulgaris: pustules and blackheads
affecting other areas of the face as well.
See Acne.
Acne rosacea: pustules and dilated or
broken blood vessels with facial flushing
involving cheeks. See Acne.
Contact dermatitis: itchy vesicles and
papules that become scaly, thickened and
itchy when chronic. See Atopic, Contact,
and Stasis Dermatitis.
Tinea Scalp May be quite Seborrheic dermatitis: yellow, greasy

Capitis varied from an scales; often involves the hairline and face.
irregular-shaped See Dandruff and Seborrheic Dermatitis.
scaly patch with Impetigo: honey-coloured crusts. See
broken hairs or a Bacterial Skin Infections: Impetigo,
very inflamed Furuncles and Carbuncles.
soft, swollen
mass called a Psoriasis: symmetric distribution of silvery
kerion with hair scales on reddened base. See Psoriasis.
loss. Alopecia areata: small nonscaly patches of
sudden hair loss. See Hair Care and Hair
Growth.
Tinea Exposed Typically annular Psoriasis: thick and silvery scales often in a
Corporis areas, (round), symmetrical arrangement. See Psoriasis.
namely, erythematous Seborrheic dermatitis: yellow, greasy scales
trunk, limbs patch; scaly with affecting face, scalp and central chest. See
and face a vesicular border Dandruff and Seborrheic Dermatitis.
and central
clearing. Nummular eczema: smaller lesions usually
affecting arms, legs and neck.
Contact dermatitis: acute onset of itchy
vesicles. See Atopic, Contact, and Stasis
Dermatitis.
Lyme disease: an initial erythematous
circular lesion (erythema migrans) with a
central clearing at the site of the tick bite. It
lacks scales. See Insect Bites and Stings.
Pityriasis rosea: acute onset of small
scaled lesions in a Christmas tree
distribution on the trunk. A single salmon-
coloured patch that can be mistaken for
tinea corporis appears on the trunk 2 weeks
preceding this rash.
Tinea Symmetrical, Annular, Yeast Infections: Cutaneous Candidiasis:

Cruris involving the erythematous very red with poorly defined borders and
upper inner patch, with scales satellite lesions (vesicles, papules) outside
thigh and and central the borders of the rash. The scrotum or
groin clearing. The penis may be involved.
The penis borders are well Erythrasma: overgrowth of normal skin
and scrotum defined. bacterium, Corynebacterium minutissimum;
are usually presents as bilateral, irregular-shaped,
spared brown plaques with scales found in
intertriginous (skinfold) areas.
Psoriasis: symmetrical erythematous
patches. See Psoriasis.
Seborrheic dermatitis: usually also involves
the scalp, face and central chest. See
Dandruff and Seborrheic Dermatitis.
Tinea Palmar Usually dry, mild Allergic or contact dermatitis: acute onset
Manuum surface of diffuse scales on and very pruritic. See Atopic, Contact, and
the hand an erythematous Stasis Dermatitis.
more often base. Atopic dermatitis: usually involves other
than the skin areas. See Atopic, Contact, and Stasis
back of the Dermatitis.
hand
Psoriasis: silvery scale; involved nails are
Only one pitted. See Psoriasis.
hand may be
involved if it
occurs in
conjunction
with tinea
pedis
Infections caused by yeast (see Yeast Infections: Pityriasis Versicolor (Tinea Versicolor) and
Yeast Infections: Cutaneous Candidiasis)
Yeast Back, chest, Multiple white- Vitiligo: nonscaly, chalk-white lesions.

Infections: upper arms pink to brown Seborrheic dermatitis: yellow, greasy scales
Pityriasis macules with an involving the chest as well as the scalp. See
Versicolor overlying fine Dandruff and Seborrheic Dermatitis.
(Tinea scale.
Versicolor) Tinea Corporis: well-defined borders.
Yeast Moist areas, A “beefy red” Tinea Corporis or Tinea Cruris: well-defined
Infections: skinfolds, edematous area borders, no satellite lesions and the
Cutaneous particularly with irregular scrotum is not involved.
Candidiasis the groin edges and many Contact dermatitis: will not have satellite
small papules lesions. See Atopic, Contact, and Stasis
(satellite lesions) Dermatitis.
outside of the
borders. Psoriasis: symmetrical with well-defined
borders and no satellite lesions. See
Psoriasis.
a Tinea pedis is discussed in Athlete's Foot.
Dermatophyte Infections
Pathophysiology
The dermatophytes (an umbrella term that includes the genera Microsporum, Trichophyton and
Epidermophyton) survive on dead keratin and do not invade living tissue. They affect the top layer of the
epidermis, hair, nails and skin. Mucosal tissues are spared as they lack a keratin layer. Infections are
transmitted through direct contact with infected persons or fomites, or occasionally infected soil or
animals. Many predisposing factors can contribute to dermatophyte infections including conditions that
increase moisture such as occlusive clothing or shoes and warm, humid climates. Impaired immunity
states (e.g., diabetes, HIV infection, chemotherapy) or genetic predisposition can also increase
susceptibility to dermatophyte infection. Dermatophyte infections are commonly called ringworm or
tinea, which means fungus. Classification of tinea infections is based on their anatomic location rather
than the fungal species.1,2 See Athlete's Foot for an in-depth discussion of tinea pedis.
Tinea Barbae
Coarse hair of the beard area and occasionally the mustache area in adult men may become infected
with tinea. Typically this is a disease spread by animals to farm workers. The lesions are usually
unilateral and may appear as typical scaly patches, follicular pustules or erythematous kerions.1,6
Tinea Capitis
Tinea capitis is a dermatophyte infection involving the scalp hair follicles and adjacent skin. Children
are primarily affected. The most common form, “black dot tinea capitis,” often appears as an annular
patch of itchy, scaling skin and hair loss. Hairs may eventually break off flush with the scalp surface,
and debris in the follicle formerly occupied by hair appears as black dots.7
A less common type of tinea capitis contracted from cats and dogs, called “gray patch tinea capitis,”
causes hairs in the affected area to turn grey as a result of loss of the hair sheath. The hairs break 1
or 2 millimetres above the scalp and the remaining hair stubs have a frosted appearance. The initial
erythematous, scaling patch eventually subsides.
Tinea scalp infections may result in a hypersensitivity response where some patients develop a
boggy inflammatory mass called a kerion that can result in scarring and permanent hair loss.
Tinea of the scalp is common in low socioeconomic and crowded environments, and the causative
dermatophyte species vary among different countries. It is contagious via direct contact with infected
persons, animals or contaminated clothing (e.g., hats, combs). Affected shedded hairs can harbour
viable organisms for more than 1 year.1,2
Tinea Corporis
The classic presentation affects the smooth and bare (glabrous) areas of the trunk or limbs
(excluding the face, hands, feet and groin) and begins as a flat, circular, scaly spot with a clearing
central portion and a raised vesicular red border that advances circumferentially outward.1,2 (See
photo, Tinea Corporis). Outbreaks of tinea corporis can occur in athletes who have skin-to-skin
contact, such as wrestlers, where it is called tinea corporis gladiatorum.7,8
Photo 1: Tinea Corporis
iStockphoto
Tinea Cruris
Tinea cruris or “jock itch” involves the groin area (medial and upper parts of the thigh and the pubic
area). Occasionally the anal cleft is affected. Unlike yeast infections, the scrotum and penis are
usually spared. The infection occurs most often in men during the summer months. Often a reservoir
for the infection is found on the feet.7 The lesions are usually bilateral, scaly with red-brown centres
and a clearly defined, raised border. Pruritus is common.1,2,7
Tinea Manuum
An infrequent infection, tinea manuum may present as the classic pattern of limited erythema and
scaling of the dorsal surface of the hands. Another form affecting the palmar hand surfaces
produces diffuse dryness and hyperkeratosis of only one palm and is associated with tinea pedis,
referred to as “two feet–one hand syndrome.”1,2
Tinea pedis/athlete's foot is discussed in Athlete's Foot.

Goals of Therapy
Eradicate causative organism
Resolve lesion and symptoms
Prevent spread of infection
Prevent secondary complications
Patient Assessment
Assess patient's signs, symptoms and history including:
Location and distribution of lesions

Aggravating factors, affect on activities and quality of life
Treatments attempted
Characteristics and differential diagnosis of fungal skin infections can be found in Table 1. Topical
antifungal treatment is effective for tinea corporis, tinea cruris and tinea pedis.4
Further assessment and/or treatment is required in those patients who are:5
Experiencing an infection with unclear etiology

Immunocompromised (e.g., high dose or prolonged immunosuppressant drug therapy, advanced or
uncontrolled diabetes, acquired immunodeficiency syndrome)
Experiencing tinea capitis, tinea barbae or tinea unguium (tinea of the nails) for systemic therapy
since topical agents do not penetrate the hair follicles or nails well
Responding poorly or are intolerant to topical therapy
Experiencing an extensive, disabling, multifocal or inflammatory disease
Topical therapy can be attempted for tinea manuum but because of the thickness of palmar skin and
frequent association with infected fingernails, systemic therapy is often necessary.
Skin should be kept clean and dry to discourage fungal proliferation. Using an electric hairdryer on the
cool setting will aid in drying the skin; avoid excessive rubbing with towels. Loose-fitting cotton clothing
that allows adequate ventilation is encouraged. Nonmedicated powders can be used to absorb excess
perspiration but cornstarch should be avoided since it may provide nourishment for fungi, thereby
delaying resolution. Clothing and linens of the infected person should be laundered separately from
those of other family members.3,4
Topical pharmacologic options available for the treatment of dermatophyte skin infections include
clotrimazole, ketoconazole, miconazole, terbinafine, tolnaftate and undecylenic acid.9 Topical antifungal
treatment is effective for tinea corporis, tinea cruris and tinea pedis.10,11 The azoles (clotrimazole,
ketoconazole, miconazole) are generally more effective than tolnaftate.12,13 A systematic review
provided low-quality evidence that the topical azoles terbinafine and ciclopirox achieve comparable
clinical and mycological cure rates (all have an NNT of 2), but treatment duration is shorter with
terbinafine.14 Terbinafine treatment for 1 week has produced similar cure rates to those reported for
azole treatment for 4 weeks.15,16
Nystatin is ineffective in the treatment of dermatophytosis.9 Undecylenic acid is effective but there are
insufficient data to compare its efficacy with that of other topical antifungals.13,17
Because they are rubbed into the skin, creams and lotions are considered to be more effective than
sprays or powders, which are often used adjunctively. Lotions and powders are preferred in intertriginous
areas where creams may be more occlusive and could lead to maceration. Liberal use of antifungal
powder (e.g., tolnaftate) may help to absorb skin perspiration and prevent rubbing.
Optimal dosage regimens and durations of treatment for various fungal infections have not been
determined due to lack of quality evidence, except in the case of terbinafine treatment of tinea corporis
and tinea cruris, which is recommended to be applied once daily for 1 week.14 Treatment with other
antifungals is usually for a minimum of 2 weeks or until 1 week after the skin clears. Tinea cruris may
respond in 2 weeks while tinea corporis typically requires 4 weeks of treatment.
Patients with widespread disease or persistent recurrence or who are immunocompromised may require
treatment with systemic antifungals (e.g., oral terbinafine, itraconazole, fluconazole).
Before the advent of effective antifungal agents, keratolytics such as Whitfield's ointment (salicylic acid
3% and benzoic acid 6%) were used to produce desquamation of the fungus-containing epidermis. There
is insufficient evidence to determine whether Whitfield's ointment is effective.14 The preparation can be
irritating and, if used over a large surface area, can lead to salicylate toxicity.18 Safer and more effective
antifungal agents are preferred.
Topical corticosteroids may suppress the signs of the fungal infection by altering the appearance of the
lesions, which are then called “tinea incognito.” Corticosteroids may also decrease the local immunologic
reaction in persistent or recurrent infections or accelerate fungal growth resulting in the invasion of
deeper tissues.19 However, in severe inflammatory cases, a low-potency topical corticosteroid may be
used in combination with the topical antifungal for a short period until itch and irritation are relieved,
after which the antifungal is continued alone for the remainder of the treatment period.14 The
combination of corticosteroid and antifungal agent should be avoided in occluded areas and on the
face.20
More information regarding topical therapy for fungal skin infections can be found in Table 3.
Table 2 provides a monitoring plan for patients with fungal skin infections.
.....
Yeast Infections: Pityriasis Versicolor (Tinea Versicolor)
Pathophysiology
Pityriasis versicolor is an infection of the stratum corneum of the skin where sebaceous glands are
present, especially the upper trunk. Since the term tinea refers to diseases caused by dermatophytes, the
preferred term for this infection, which is caused by yeast (and not dermatophytes), is pityriasis
(meaning scaling). Malassezia species (formerly called Pityrosporum orbiculare or Pityrosporum ovale)
normally colonize the skin but cause an opportunistic infection in association with hereditary factors,
immunodeficiency, malnutrition, oily skin, hyperhidrosis or use of corticosteroids or oral
contraceptives.24 It affects about 3% of the general population and occurs most commonly in
postpubertal adults and in warm, humid climates.25,26 The term versicolor denotes a variety of colours
or changing colours.
The most common presentation is multiple white to reddish-brown macules that may coalesce to form
large patches of various colours ranging from white to tan. A fine scale is apparent when scratched. The
lesions tend to be darker than the surrounding skin in fair-skinned patients and lighter in dark-skinned
patients. This is primarily a cosmetic problem where the lesions do not tan along with the surrounding
normal skin. Recurrence rates are as high as 60–80%.27 (See photo, Pityriasis Versicolor). It is not
considered contagious and is not due to poor hygiene.25
Photo 2: Pityriasis Versicolor
Science Photo Library
Goals of Therapy
Reduce or eliminate yeast elements
Reduce or eliminate skin lesions and symptoms
Prevent recurrences of infection
Patient Assessment
Characteristics and differential diagnosis of pityriasis versicolor can be found in Table 1. Patients with
pityriasis versicolor usually have only cosmetic manifestations; pruritus is unusual. Self-care measures
are appropriate for those with pityriasis versicolor. If the etiology of the infection is unclear, patients
require further assessment to confirm diagnosis.26,28
Because yeasts thrive in moist environments, controlling excess heat and humidity may be helpful. Avoid
application of oil to the skin, as Malassezia species can overgrow in such an environment.
Pityriasis versicolor can be successfully treated with a number of topical antifungal agents. Those used
most commonly include topical azoles (clotrimazole, ketoconazole, miconazole) and selenium sulfide
2.5% suspension.
Ketoconazole is the most extensively studied treatment approach. In one meta-analysis, topical
ketoconazole was associated with a mycological eradication rate of 65% compared with 45% for
terbinafine.29 Another study found ketoconazole 2% shampoo produced clinical cure rates of about
70%.30 Other azoles such as clotrimazole and miconazole, as well as the hydroxypyridone ciclopirox
olamine, appear to have equivalent efficacy.29,31,32,33
Selenium sulfide suspension has traditionally been used and remains effective.34,35 It appears to be as
efficacious as topical azoles and is more cost effective when the condition is widespread.25
Topical terbinafine has been used but has inferior evidence of efficacy.31,32,33
Other topical agents such as sulfur 2%, salicylic acid, zinc pyrithione 1% or 2% shampoo, benzoyl
peroxide or extemporaneously compounded propylene glycol 50% have demonstrated limited efficacy in
older trials.18,25,36,37,38
Oral therapy for patients with extensive infection or those who are intolerant of or unable to use topical
therapy includes fluconazole (400 mg single dose or 300 mg weekly for 2 weeks) or itraconazole (200
mg daily for 5–7 days).25,26,32,39 Oral terbinafine is ineffective.31 Oral ketoconazole is not recommended
due to the risk of hepatotoxicity.40
Preventive Therapy
Pityriasis versicolor has a high rate of recurrence; prophylactic treatment with topical or oral therapy on
an intermittent basis is often necessary. Preventive treatment with once- to twice-monthly applications of
selenium sulfide suspension can reduce the recurrence rate to less than 15%. Soaps or shampoos
containing zinc pyrithione, salicylic acid or sulfur can also be used.9 Itraconazole 200 mg taken once
monthly has also been used successfully.41
A monitoring plan for patients with fungal skin infections is provided in Table 2. Resolution of scaling
with pityriasis versicolor occurs promptly but the pigmentary changes may take weeks to months to
resolve.
.....
Yeast Infections: Cutaneous Candidiasis
Pathophysiology
Candida yeasts are part of the normal flora of the oropharynx, intestinal tract and vagina. Infections arise
when skin pH is increased, competing bacteria are removed by antibiotic treatments, glucose content in
sweat increases (as in diabetes) and/or the surrounding environment is warm and moist.42,49 With
impaired host defenses, infections may not only affect skin, nails or mucous membranes but may also
rarely lead to systemic infections. Risk factors for cutaneous candidiasis include diabetes mellitus,
malignancy, obesity, tropical environment, neutropenia, HIV infection, psoriasis, contact dermatitis and
use of corticosteroids, antibiotics, cytotoxic or immunosuppressant agents.26,42,43 See photo,
Candidiasis (Intertrigo).
Photo 3: Candidiasis (Intertrigo)

Custom Medical Stock Photo/Science Photo Library
The most common form of Candida albicans infection is intertrigo. Any skinfold area such as the gluteal
fold, axillae (armpits), interdigital spaces, area under breasts or abdominal folds can be affected. These
occluded areas create moist, warm environments ideal for C. albicans to flourish.26 Intertrigo is often
colonized with bacteria, which can lead to a secondary bacterial infection. This may result in cellulitis,
especially in patients with diabetes. In addition, the macerated skin can break down to cause fissures
and ulcers, particularly in the deep folds of obese persons, leading to pain and disability.44,45
Candidal paronychia occurs in individuals who have their hands in water excessively. This condition
consists of painful, reddened and swollen nail folds. Chronic infection can lead to transverse
depressions of the nail plate and brownish discoloration and eventual separation of the nail plate from
the nail bed (onycholysis).31,46 See Fungal Nail Infections (Onychomycosis).
Goals of Therapy
Eradicate or reduce yeast elements
Eliminate or reduce lesions and symptoms
Prevent spread of infection
Prevent recurrences
Patient Assessment
A description and differential diagnosis of cutaneous candidiasis is provided in Table 1. The lesions are
red, macerated patches with irregular scalloped borders. Papules and pustules called satellite lesions
form outside of the borders. Symptoms of pruritus and soreness are common.9
Patients with widespread, systemic or persistent, recurrent infection or those who are
immunocompromised require further assessment and/or treatment by an appropriate health-care
practitioner.
Hygiene measures such as daily bathing and avoidance of tight-fitting clothing aid in skin dryness,
making a less desirable environment for yeasts. Useful measures for keeping the area dry include using
cool water compresses (1 minute on, 1 minute off) for 15–20 minutes 3 times daily. The affected area
should be air dried afterwards. Applying nonmedicated powders several times daily helps to reduce the
moisture in skinfolds and may help prevent the infection.47 Although 1 study did not find enhanced yeast
growth,48 it is recommended that the use of cornstarch be avoided as this may promote the growth of
Candida.7
Many topical antifungal agents are effective for the treatment of cutaneous candidiasis including azole
antifungals (e.g., clotrimazole, ketoconazole, miconazole) nystatin, ciclopirox olamine and terbinafine
(see Table 3). Tolnaftate and undecylenic acid are ineffective.
If there is pronounced inflammation, low- to mid-potency topical corticosteroids may be used sparingly
once or twice daily for short periods (1–2 weeks) in conjunction with an antifungal.42,49 Stronger topical
corticosteroids should be avoided as the occlusive effect of skinfolds can increase absorption of the
corticosteroid and accelerate skin atrophy and striae.46
Monotherapy with drying antifungal powders (e.g., miconazole spray) is less effective than monotherapy
with antifungal creams or ointments due to comparatively decreased skin penetration.49
In widespread cutaneous disease and immunocompromised patients, oral azole antifungals (e.g.,
fluconazole, itraconazole) may be indicated. Oral terbinafine may not be as effective as oral azole
antifungals.50
Substantial improvement should be evident within 1 week of topical treatment. If topical corticosteroids
are used (with antifungals) to control an inflammatory intertrigo, patients should be monitored closely for
the development of a hidden bacterial infection or striae.45
Persistent candidal infection may be a sign of immunosuppression and these patients should undergo
further investigation. Table 2 suggests a monitoring plan for patients with fungal infections.
.....
A number of herbal therapies have been used for a variety of fungal skin infections, including goldenseal,
purple coneflower (Echinacea), slippery elm bark, St. John's wort and tea tree oil (Melaleuca). There is
insufficient evidence to recommend the use of any of these herbs.51,52 One study of tea tree oil in tinea
pedis showed some benefit.53
Table 2: Monitoring of Therapy for Fungal Skin Infections
Symptoms Monitoring Desired Actions
Outcome
Lesions specific for Patient: daily for lesions Clearing of all If no improvement or
each fungal infection decreasing in size and lesions within 4 spreading of lesions
no more new lesions wk by 1 wk, patient
developing requries further
Health-care practitioner: assessment and/or
next visit treatment.
Symptoms Monitoring Desired Actions
Outcome
Pain, swelling, Patient: daily for any No development Patient requires
redness or drainage evidence of new onset of these further assessment
of these symptoms symptoms and/or treatment if
Health-care practitioner: these symptoms
next visit develop, as they may
indicate a bacterial
superinfection.
Recurrent lesions Patient: watch for No new lesions Patient requires

recurrence of any new further assessment to
lesions for weeks or rule out any
months following initial underlying
infection predisposing
conditions.
Emphasize preventive
measures.
Inflammation being Patient: daily Resolution of If no improvement or

treated with inflamed areas lesion is worsening by
corticosteroids 1 wk, patient requires
further assessment
and/or treatment.
Emphasize correct
use of cool
compresses.
Allergy Patient: daily while on No allergy Stop therapy. Patient

therapy requires further
assessment and/or
treatment.
Irritation caused by Patient: daily while on Little to no Stop therapy if no

topical agents therapy irritation, which improvement in
Health-care practitioner: subsides with irritation secondary to
after 1 wk or next continued use the topical agent after
pharmacy visit several doses.
Drug Table
Table 3: Topical Antifungal Agents21,22

cream, spray
Drug/Costb Dosage Adverse Comments

Effects
Drug Class: Allylyamines

Effects
terbinafine Tinea corporis/cruris: once daily Irritation, Effective for treatment

1% cream, × 1 wk burning, of infections caused
spray Pityriasis versicolor: once daily– erythema, by dermatophytes or
Lamisil BID × 1–2 wk contact yeasts.
dermatitis. In dermatophyte
$$ Cutaneous candidiasis: once infections: less
daily–BID × 2 wk frequent application
and shorter duration
of treatment than
other topical
antifungals.
Drug Class: Azoles
clotrimazole Tinea corporis: BID × 4 wk Irritation, Effective in treatment

1% cream Tinea cruris: BID × 2–4 wk erythema, of infections caused
Canesten itching, by dermatophytes or
Topical, Pityriasis versicolor: BID × 2 wk stinging. yeasts.
generics Cutaneous candidiasis: BID × 2– Hypersensitivity
3 wk reactions (rare).
$
ketoconazole Tinea corporis: once daily × 3–4 Itching, burning, Effective for treatment
2% cream, wk stinging, skin of infections caused
shampoo Tinea cruris: once daily × 2–4 wk sensitivity, by dermatophytes or
Ketoderm, Pityriasis versicolor: shampoo itching, contact yeasts.
Nizoral (used as a lotion): scrub into dermatitis. Various regimens
affected area then rinse off after have been studied and
$ found to be effective.
5 min
Single dose or once daily × 3 Regimens with longer
days durations of treatment
Cream: once daily × 2–3 wk may lead to longer
time before
Cutaneous candidiasis: once
recurrence.23
daily × 2–3 wk
miconazole Tinea corporis: BID × 4 wk Irritation, Effective for treatment

2% cream Tinea cruris: BID × 2–4 wk erythema, of infections caused
Micatin itching, by dermatophytes or
Derm, Pityriasis versicolor: BID × 2 wk stinging. yeasts.
Monistat Cutaneous candidiasis: BID × 2– Hypersensitivity
Derm, 3 wk reactions (rare).
generics
Drug Class: Hydroxypyridone

Effects
ciclopirox Tinea corporis/cruris: cream or Itching, burning, Effective for treatment

olamine 1% lotion: BID × 4 wk stinging, skin of infections caused
cream, Pityriasis versicolor: cream or sensitivity, by dermatophytes or
lotion, lotion: BID × 2 wk contact yeasts.
shampoo dermatitis.
Loprox, Shampoo: twice weekly × 2 wk
Stieprox
$$
Drug Class: Polyenes
nystatin 100 Cutaneous candidiasis: BID–TID Irritation (rare). Ineffective in

000 units/g × 2–3 wk treatment of
cream, dermatophytoses.
ointment
generics
Drug Class: Thiocarbamates
tolnaftate 1% Tinea corporis or cruris: BID × 2– Local skin Ineffective in

Tinactin 4 wk irritation. treatment of
cutaneous
$ candidiasis.
Drug Class: Other antifungal agents
selenium Pityriasis versicolor: apply to Skin irritation.

sulfide 2.5% affected areas and lather with a
suspension small amount of water. Allow
Selsun product to remain on skin for 10
min, then rinse the body
$ thoroughly. Use once daily × 1–2
wk
Prevention: once to twice
monthly
undecylenic Tinea corporis: BID × 4 wk Itching, burning, Ineffective in

acid 1% gel, Tinea cruris: BID × 2 wk stinging. treatment of
liquid cutaneous
Fungicure candidiasis.
a Application instructions (unless otherwise stated): skin should be clean and dry. Apply in a thin layer to the
affected area and 2–3 cm beyond its border, and rub in lightly.
Legend: $ <$10 $$ $10–20
Suggested Readings
49. UpToDate. Parker ER. Candidal intertrigo. Available from: www.uptodate.com. Accessed July
2015. Subscription required.
50. McClellan KJ, Wiseman LR, Markham A. Terbinafine. An update of its use in superficial mycoses.
Drugs 1999;58:179-202.
51. Gardiner R, Kemper KJ. Herbs in pediatric and adolescent medicine. Pediatr Rev 2000;21:44-57.
52. Natural Medicines Comprehensive Database. Available from: www.naturaldatabase.com.
Accessed July 2015. Subscription required.
53. Satchell AC, Saurajen A, Bell C et al. Treatment of interdigital tinea pedis with 25% and 50% tea
tree oil solution: a randomized, placebo-controlled, blinded study. Australas J Dermatol
2002;43:175-8.

Fungal (Tinea) Infections
Fungal (Tinea) Infections—What You Need to Know
What is tinea?
Tinea is a kind of fungus that can grow on your skin, hair or nails. Tinea lives in soil, on animals and on people. It grows
quickly in damp areas. As long as the fungus stays on the surface of the skin, it will not cause any problems. However, if it
gets into a cut or scrape on the skin, it can cause a fungal infection.
As the fungus grows, it spreads out in a circle leaving normal-looking skin in the middle. At the outside of these ring-shaped
spots, there is a raised red border that looks a bit like a worm under the skin. Because of the way it looks, a tinea (fungal)
infection is often called "ringworm." However, there really isn't a worm under the skin.
You can get a fungal infection anywhere on your body or on your scalp. If you get a fungal infection in the groin area, it is
called jock itch. Jock itch is more common for men because they often wear athletic equipment. If you get a fungal infection
on your feet (usually between the toes), it is called athlete's foot ( Athlete's Foot—What You Need to Know).
How do you get a fungal infection?
You may be exposed to tinea in a number of ways:
By touching a person who has a fungal infection

By walking barefoot in a damp area like a public shower or locker room
By touching an animal that has a fungal infection
What are the signs of a fungal infection?
Skin that is itchy, light red or scaly.

Small ring-shaped spots on the body that grow larger as the infection spreads. The skin at the outside of the
ring is red and scaly. Inside the ring, the skin looks normal.
If the infection is on the head, it may look like dandruff with patchy, scaly spots and stubby hair.
If the infection is in the groin area, the skin may be moist and itchy. It may also feel hot.
What is the treatment for tinea (fungal) infections?
Tinea can be treated with antifungal creams, lotions or shampoos. Ask your health-care provider for advice
about these products.
Wash and dry the affected area well. Apply an antifungal product to the rash twice a day. Spread it on the rash
and about 2–3 cm outside its borders.
Treat jock itch for 2 weeks and ringworm of the body for 4 weeks.
How can you prevent the spread of tinea?
Keep the skin clean, cool and dry. This will discourage growth of the fungus.
Change your socks and underwear every day, especially in warm weather.
Wear clean cotton clothing that allows fresh air to circulate.
Apply powder to absorb sweat and prevent rubbing.
When should you see your doctor?
If you have ringworm that continues to spread after 1 week of treatment with an antifungal product.
If you have a jock itch rash that has not gone away after 2 weeks of treatment or a ringworm rash that has not
gone away after 4 weeks of treatment.
If a rash comes back after treatment.
If you have an infection on your scalp or nails. You will need a prescription medication to get rid of the infection.
end
Hair Care and Hair Growth

Pathophysiology
Humans are born with a fixed number of hair follicles. Approximately 100 000 hair follicles are on the scalp alone. Two types of hair
are found on a human body: vellous and terminal. Vellous hair is fine, soft hair that is nonpigmented and covers the body. Terminal hair
is generally long, course hair that is pigmented and covers the scalp, face, axillae and pubic area. Terminal hair grows on the face,
chest, legs and arms in response to androgens at puberty. Decreased estrogen levels can also allow androgens to stimulate terminal
hair growth in menopausal women.1
Hair growth occurs in 4 stages on the scalp:
1. The active growing phase or anagen stage lasts 2–6 years and determines hair length. Normally about 80–90% of follicles are in
this stage at any one time on a human scalp
2. The transitional phase or catagen stage can last 2–3 weeks after which the follicle degenerates and growth stops. On a normal
scalp approximately 1–3% of the follicles are in this stage
3. The third stage is the resting phase or telogen stage which lasts 3–4 months. Approximately 5–10% of follicles are in this stage
on a normal scalp
4. The last stage of hair growth is the shedding phase or exogen phase where the hair is shed and the cycle of growth begins again.
Normally about 75–100 scalp hairs are shed each day or about 0.1% of scalp hair.
Repeated chemical treatments, poor grooming habits and exposure to the environment can cause hair texture to change and result in
hair breakage. This progressive degeneration of the hair shaft is called “weathering” and contributes to structural weakening of the
hair, making it tangle easier and appear rough.2
Hair Loss (Alopecia)
Androgenic alopecia sometimes referred to as androgenetic alopecia is the most common type of hair loss. It is commonly
referred to as male-pattern baldness or female-pattern baldness.
Characteristics of androgenic alopecia include:
A hereditary form of androgen-induced diffuse hair loss that presents as a reduction in hair thickness as well as hair loss
The exact influence of genetics on androgenetic alopecia is unknown. The androgen receptor gene is located on the x
chromosome and passed from mother to son; however, family studies have also shown marked resemblance of hair loss
between fathers and sons3
The actual number of hair follicles remains the same and the growth cycle is constant but the anagen or growth stage is
somewhat shorter producing a shorter, thinner hair shaft. This thinner hair shaft covers less scalp, the area becomes
progressively becomes larger, and balding appears, particularly in men
In men, hair thinning starts in the crown area, gradually progressing to the mid-scalp area
Female-pattern baldness is also referred to as androgenetic alopecia but it appears that androgens player a smaller role than
in male-pattern baldness
Hair loss in women is milder than in men and presents as central thinning or “widening of the part line”.
Telogen effluvium is an abnormal number of hair follicles prematurely entering the telogen or resting phase. Characteristics of
telogen effluvium include:
Excessive hair shedding and thinning occurs in the scalp, possibly followed about 3–4 months later by hair loss in pubic and
underarm areas. More than 300 hairs are lost per day (normal is 75–100 per day)
Causes can include hormonal changes during pregnancy, severe psychological stress, injury or stress from infections, serious
illness or major surgery, endocrine disorders, iron deficiency and crash diets
In about one-third of the cases no cause can be definitely determined
Hair loss generally begins 1–3 months after the causative event
Hair loss can last up to 6 months after correcting the causative factor.
Anagen effluvium is the loss of hair over the entire scalp. Characteristics of anagen effluvium include:
Can be caused by chemotherapy, radiation to the head, certain medications (see Table 1) and heavy metal toxicity
Hair loss is usually sudden and severe, affecting most of the anagen scalp hairs simultaneously
Normal hair growth is generally rapidly restored once the underlying cause is removed.
Alopecia areata is an autoimmune inflammatory disorder that affects the hair follicles and nail matrix. Characteristics of alopecia
areata include:
Occurs at any age but commonly affects children and younger adults
Can be associated with pre-existing autoimmune disorders such as thyroid conditions, systemic lupus erythematosus and
vitiligo
There is also a family history connection as those with early onset often have a close family member with the condition
Physical stress, emotional stress and some types of infections can also cause this condition
Typically presents as smooth round or oval patches on the scalp but also can appear on any other hairy areas of the body
There is no clinical evidence of inflammation or scarring in the affected area
Nail pitting or ridging can also occur and may be a function of the disease itself
Generally self-limiting and hair can spontaneously regrow. Chronic, extensive forms are often associated with a family history
of hair loss that may not regrow. This chronic hair loss can occur in children with an onset prior to 5 years of age.
Inflammatory scalp conditions caused by bacterial infections, parasitic infections and dermatitis can cause hair loss. Compulsive
self-inflicted hair loss (trichotillomania) can also cause patchy hair loss. These conditions usually present with erythema, scale,
itch or irritation.
a,1
Table 1: Drugs Associated with Hair Loss
ACE inhibitors (captopril, enalapril) Antiparkinson agents (levodopa)
Androgens (systemic and oral testosterone) Beta-blockers (metoprolol, propranolol)
Anticoagulants (warfarin) Cholesterol-lowering agents (clofibrate)
Antiepileptic drugs (valproic acid) H2-antagonists (cimetidine)
Antimanic agents (lithium) Heavy metals (mercury, lead)
Antimitotic agents (colchicine) Oral contraceptives
Antineoplastics Oral retinoids (isotretinoin)
a Specific drugs listed are given as examples only; other medications in the same class may have similar effects.
Excessive Hair Growth
Hirsutism is the production of excessive terminal hair in a male-pattern distribution in women. It is usually a consequence of
increased androgen activity in women caused by an underlying medical problem such as polycystic ovary syndrome, androgen-
secreting tumors, Cushing syndrome, acromegaly or thyroid dysfunction. Androgenic medications (danazol, testosterone) may also
be a cause of hirsutism and must be considered when diagnosing this condition.4 Many peri- and postmenopausal women
experience increased facial hair growth due to hormone fluctuations.5
Hypertrichosis is excessive hair growth that is either hereditary or caused by medications such as glucocorticoids, phenytoin,
minoxidil or cyclosporine. Hypertrichosis is not caused by increased androgen activity but can be aggravated by it.4
Goals of Therapy
Goals of therapy for hair loss:
Correct or treat underlying conditions that may be causing hair loss
Maintain healthy-appearing hair by decreasing the rate of thinning and increasing coverage in areas of loss
Consider changing medications if causative factor
Manage psychological factors such as self-esteem and mood changes
Goals of therapy for excessive hair growth:

Correct or treat underlying conditions that may be causing excessive hair growth
Remove or control growth of, excess body hair
Consider changing medications if causative factor
Manage psychological factors such as self-esteem and mood changes
Patient Assessment
The assessment process is an opportunity to educate patients about the various factors that contribute to hair growth changes and
effective treatment methods to either reverse or cosmetically cover the condition. Patients require further investigation when they
present with unusual changes in hair growth and/or significant concerns about their hair changes. An approach to the patient with
hair-related concerns is presented in Figure 1 and Figure 2.
Hair Care
Hair colour, texture, body and curliness is genetically determined. Shiny hair that has a smooth texture and clean cut ends and has
not been damaged by chemical treatments is considered “healthy hair”.6 When the cuticle is damaged, hair can appear dull, feel
rough and brittle and have split ends.
To maintain healthy hair and minimize damage:
Have hair cut by a professional to remove ends that are damaged

Use appropriate shampoos designed for the type of hair (dry, damaged or chemically treated hair) and condition hair regularly
(according to the recommended frequency for the specific product)
Minimize exposure to harsh chemical treatments such as permanents, dyes, bleaches and straighteners6
Avoid excessive brushing. Use a brush with natural, round-ended bristles, and brush gently. Use a wide-toothed comb to
detangle or comb wet hair
Minimize use of blow dryers, curling and straightening irons.6 Use a lower setting on a blow dryer, and use a diffuser to blow
dry chemically treated hair.
The frequency of hair washing may be influenced by length of hair, culture, sex, social pressures, economics and individual
preference; daily washing is not harmful. Various hair care products can be used to cosmetically enhance the hair's appearance
(See Table 2).
2,6,7,8,9
Table 2: Hair Care Products
Product Action Uses Comments
Shampoo Detergent component helps Routine use as part of a Shampoos are formulated for
remove oil, dirt, sweat, fungal personal hygiene regimen to hair that is considered to be
elements and hair care maintain healthy hair. normal, greasy, dry or
products (styling gels, hair chemically treated.
spray). Daily use is not harmful
Primarily cleans the scalp but provided the product is well
also prevents hair shaft formulated.
damage.
Baby shampoos contain
amphoteric detergents that
are less irritating to eyes.
Conditioner Contains cationic polymers Restores appearance, Instant conditioners are

(balance the negativity of softness and manageability applied immediately after
damaged hair), film formers of hair. shampooing and left on for a
(fill hair shaft defects) or Decreases friction, frizz and short period of time.
proteins (thought to restore tangles. Deep conditioners, used for
protein to damaged hair). very dry hair are creams that
Lubricates and moisturizes Reconditions hair after
chemical treatments and are left on for 20–30 min and
hair leaving it soft, smooth may or may not require heat
and hydrated, which physical trauma such as blow
drying and brushing. to increase penetration.
decreases static.
Reduces static electricity and
restores manageability by
reducing friction on the hair
shaft.
Styling gels, sprays, Contain large-molecular- Creates changes in hair Can be used to improve
mousses, sculpting weight polymers, proteins, volume or style. appearance of hair loss (add
gels and waxes and/or resins to hold hair in May be useful for those with volume, make hair look fuller,
place or coat hair, adding thinning hair, low hair density keep hair in place to cover
thickness and texture. or if increased volume is thin areas).
Silicone-containing products desired. Mousses aid in styling, are
provide sheen, lubricate and soft to touch and can be
increase resistance to easily removed. Styling
humidity, making hair more lotions are applied to wet hair
manageable. and hold style when blow
drying.
Product Action Uses Comments
Hair colouring agents Dyes that cause a gradual Alter the colour of hair Gradual dyes must be used
hair colouring use metallic through various methods. continuously for colour
dyes that cause a chemical Gradual dyes change grey change to remain, and are
reaction on the hair shaft. hair incrementally over a few inexpensive. Hair can become
Temporary colours are water- weeks to brown or black. stiff, dull and brittle and
soluble dyes consisting of colour quality is often poor.
Temporary dyes are used to
large molecules that are cover small amounts of grey, Temporary dyes are safe and
deposited on the hair shaft. brighten natural or coloured gentle. They are available as
Semipermanent dyes are hair or remove yellow tones rinses, gels, mousses or
mainly synthetic. They from grey hair. sprays that are easily washed
consist mainly of low- out.
Semipermanent dyes are
molecular-weight coal tar used to cover grey, produce Semipermanent dyes can
dyes that penetrate the hair highlights or to change hair cause contact dermatitis.
shaft easily. Permanent tones. These dyes last 4–6 wk
colour results from an depending on the condition of
oxidation process within the Permanent dyes are used to the hair. Natural vegetable
hair shaft and is irreversible. cover grey or change hair dyes such as henna have
colour. largely been replaced by
synthetic formulations for
use as semipermanent dyes.
Permanent dyes are re-
applied every 4–6 wk
depending on rate of hair
growth. These dyes contain
ammonia and/or peroxide
and can damage hair.
Permanents, Changes the chemical Used to either curl or add Process must be repeated
straighteners/relaxers structure of hair shaft by wave to hair or to straighten every 6–12 wk based on
altering disulfide bonds. hair that is naturally curly. individual's hair. May damage
Chemical hair straightening hair if too strong, left on too
also involves mechanically long, used too frequently.
straightening the hair once it Often irritates the scalp.
has been treated.
Hair Loss
Nonpharmacologic options for patients with hair loss include cosmetic hair products such as sprays, foams and lotions that make
the hair look thicker.10 Hair extensions, wigs and hair pieces are also becoming more acceptable and improving in quality, providing
a minimally invasive method to cover hair loss areas.
Follicle transplants can be considered when there has been limited success with medical treatments. The procedure is done on an
outpatient basis under local anesthesia. The transplanted hair will grow over 3- to 6-month period postprocedure.
A number of devices for home use that administer low-level laser therapy (supposedly to stimulate metabolic processes needed
for hair growth) are being investigated and aggressively marketed. Industry sponsored studies appear promising, but there is no
independent evidence of effectiveness and anecdotal reports so far are disappointing.11,12
Excessive Hair Growth
Weight loss may lead to decreased androgen levels and subsequent improvement in excessive hair growth in obese women,
particularly in those women with polycystic ovary syndrome.13
Excess hair can be routinely controlled with physical removal by shaving, waxing, plucking or the application of depilatory creams,
or camouflaged by bleaching. These forms of physical removal are all associated with the regrowth of the hair and will often be
used in combination with more permanent hair removal methods. Hair does not grow back any faster, thicker or denser than
normal.14
Shaving removes hair at the skin level and is suitable for most areas, but the hair grows back quickly. This method does not affect
the rate of hair growth and is a safe and inexpensive way to control regular hair growth.15
Cold waxing involves application of wax-impregnated strips that are pressed on the skin then pulled off in the direction opposite to
hair growth. Warm waxing involves wax that is heated to 37°C and then spread over the area in the direction of hair growth. The
waxed area is covered with strips and allowed to cool. The strips are then pulled off against the direction of hair growth. Hot
waxing consists of melted wax spread over the desired area against the direction of hair growth and allowed to cool. It is then
quickly pulled off.16 Waxing allows the area to be free of hair for several days but is painful when performed by someone not
trained in the field.
Plucking can be effective for small areas (eyebrows, upper lip and chin), but is time consuming, painful and temporary.16,17
Threading is a process by which twisted cotton thread is used to pull the hair from the follicle. It is used to temporarily remove hair
from small areas. Training and experience are necessary to obtain a good result.
Bleaching lightens hair so that it is not as noticeable. Several products are available; all contain hydrogen peroxide and many
contain ammonia (accelerates the bleaching action). Bleaching is fast, generally painless and reserved for small areas. Results can
last up to 4 weeks. Side effects include skin irritation and hair discoloration.17
Depilatory creams act by separating the hair from the follicles. Hair regrowth can begin within a few days of treatment. These
methods are best used for weekly hair removal or in combination with laser treatment. Contact dermatitis (allergic and irritant) can
occur with the use of these products because of the alkaline nature as well as the added fragrances. Some find the products
messy and the odour offensive which limits their use.17
Laser systems and intense pulsed light sources (IPL) both work on the same principle, selectively targeting specific areas without
affecting the surrounding tissue. Melanin pigment in the hair follicles absorbs the wavelength selected, effectively destroying the
hair follicle via thermal damage and impairing future hair growth.17 A Cochrane review that examined studies of laser and IPL
procedures concluded that permanent hair removal is not a realistic expectation.18 More realistically, long-term stable reduction in
hair regrowth lasting 4–12 months can be accomplished with these procedures.17,18 Side effects can include mild to moderate
pain, skin redness, pigment changes and burned hairs. These side effects are dependent on the type of laser used for treatment.17
Topical anesthetics containing lidocaine and prilocaine are commonly used prior to laser treatment to decrease pain from the
procedure. Consumers may apply these products in larger amounts and to a larger area than is recommended, increasing the risk
of serious side effects,19 such as CNS toxicity, methemoglobinemia and cardiovascular collapse. Systemic effects may manifest
as headache, drowsiness, respiratory depression, confusion, convulsions, hypotension and cardiac arrhythmias.19 Laser and IPL
treatments are expensive and must be administered by a trained professional on a regular basis to maintain hair removal.4 A
number of hand-held, home-use laser and light devices can be purchased for personal use. Non-industry–sponsored evidence of
safety and effectiveness is not available.12
Electrolysis is an option for the removal of unwanted hair. A small needle or metal probe is inserted into the hair follicle and low-
level electrical current is used to destroy the follicle. It is important that the procedure be performed by a trained and certified
professional. The designations C.P.E. (Certified Professional Electrologist) and C.C.E. (Certified Canadian Electrologist) indicate the
electrologist has satisfied a board of examiners and is a member in good standing.
Hair Loss
Information about the management of hair loss can also be found in Table 4.
Topical Therapy for Hair Loss
Products: Hair Growth.
Minoxidil has been shown to be effective for the treatment of male-pattern26 and female-pattern hair loss.27 The mechanism of
action of minoxidil is unclear but it is thought to stimulate the conversion of small hair follicles to larger follicles. Minoxidil
prolongs the duration of the anagen phase and increases hair count and weight.28,29 Minoxidil 2% solution is approved for male-
pattern hair loss only and minoxidil 5% foam is approved for both male- and female-pattern hair loss. Minoxidil is most effective
when started early, prior to the area becoming completely bald. Hair growth is visible within 2 months or more with a maximum
effect within a year.28,30 Daily application is required indefinitely to maintain hair growth.1 Transitory increased hair shedding may
occur during the first 1–2 months of treatment due to telogen (resting phase) follicles being stimulated to re-enter anagen
(growing phase). Patients should be advised that this may occur and that it will normalize within a few weeks to months.26 The
most common side effect is contact dermatitis at the application site, which is possibly caused by propylene glycol.31
Compounding minoxidil using butylene glycol instead of propylene glycol may decrease this side effect.31 Minoxidil 5% foam
formulation is propylene glycol–free, causes less scalp irritation and improves adherence.32 This formulation is more cosmetically
pleasing as it is less greasy, and it is easier to apply to the scalp only and avoid the hair. Systemic absorption of minoxidil is
minimal but tachycardia and decreased blood pressure have been reported. Use caution when recommending this treatment for
patients with cardiovascular disease or low blood pressure.28 Although systemic absorption of topical minoxidil is minimal, safety
in pregnancy has not been established and it is not recommended.33 Transfer of topically applied minoxidil into breast milk is
expected to be minimal and pose low risk to the nursing infant.34
Systemic Therapy for Hair Loss

Finasteride halts or reverses the progression of mild to moderate hair loss in men by inhibiting 5-alpha reductase–mediated
conversion of testosterone to dihydrotestosterone.26 Effectiveness rates for slowing progression of male androgenetic alopecia or
producing partial regrowth of hair range from 60–90% of patients. Regular daily use for 3–6 months may be required to see
reduced hair loss and up to 12 months to see noticeable regrowth. Hair loss resumes when therapy is stopped. The most common
side effects experienced by men using finasteride are decreased libido, decreased semen volume and erectile dysfunction. These
side effects may decrease with continued treatment and may or may not be reversible when treatment is discontinued. Finasteride
may reduce prostate specific antigen (PSA) levels by up to 50% depending on the dose and age of the patient. This should be
considered when interpreting PSA levels in patients taking finasteride.3,26,35 Evidence for use of finasteride in females is limited
and conflicting.27 Finasteride should never be used or handled by women who are pregnant or may become pregnant as it may
cause feminization of the male fetus.10 Since finasteride concentration in semen is very low, there is no risk to a fetus via
intercourse.26
Another 5-alpha reductase inhibitor, dutasteride, has also been shown to be effective in male androgenetic alopecia3 but is not
officially indicated for this condition. Side effects and precautions are similar to those for finasteride.
Hormone therapy with combined oral contraceptives, cyproterone, drospirenone, flutamide and spironolactone has been studied
for female-pattern hair loss. Evidence is sparse and of limited quality and therefore no recommendations can be made.26,27 Other
therapies being investigated include onabotulinumtoxinA and prostaglandin analogues such as latanoprost and bimatoprost.20,21
Combining therapies may help increase efficacy. Combinations that have been studied include finasteride plus minoxidil,26,36
finasteride plus ketoconazole shampoo (may help reduce androgenetic alopecia–associated follicular inflammation and is also an
anti-androgen),37 and topical or systemic therapy in combination with transplant procedures.
In the specific case of alopecia areata, many treatments have been tried with varying success. These include topical minoxidil,
topical, oral and locally injected corticosteroids, anthralin, azelaic acid and topical sensitizers such as dinitrochlorobenzene or
diphenylcyclopropenone (to stimulate an immune response).38,39
Excessive Hair Growth in Women
Information about assessment and management of excessive hair growth can also be found in Table 5.
Hormonal treatments for hirsutism either suppress androgen levels or block the effects of androgens on hair follicles. First-line
therapy for hirsutism unless contraindicated is combination oral contraceptives (COCs). Those containing ethinyl estradiol and a
minimally androgenic progestogen (e.g., desogestrel, norgestimate) can slow progression but not reverse excess hair growth and
generally require 9–12 months for maximal effect.4,13,14 COCs containing the antiandrogens cyproterone acetate or drospirenone
are also effective and may be preferred.4,13,14,22 [Evidence: SORT B] The antiandrogens spironolactone, flutamide and cyproterone
acetate are also effective. These agents have been used as monotherapy but are generally recommended in addition to COCs for
moderate to severe hirsutism that has not responded to COCs alone.13,22 Finasteride has shown inconsistent results in studies22
but is considered a second-line antiandrogen by some experts.13,23 There is evidence that eflornithine cream reduces the rate of
hair growth in women by suppressing the mitotic activity in the follicle.22,40,41 While it may be tried alone for mild cases,13 it is
generally recommended as adjunctive therapy with hair removal techniques such as laser therapy. Improvement is expected after
4–8 weeks of treatment but may take up to 24 weeks in some patients. Discontinuing use of the product results in hair regrowth
within 8 weeks of stopping treatment.14
Monitoring plans for patients should be individualized; hair loss and its psychological effects are different for each person. The degree
of hair loss (mild to moderate or severe) should also be considered when determining initial treatment and monitoring outcomes.
Table 3 provides a monitoring plan framework for both hair loss and excessive growth.
Table 3: Monitoring of Therapy for Hair Conditions

Symptom Monitoring Desired Outcome Actions
Hair thinning Monitor for improvement for a Reduced thinning, Continue therapy indefinitely if
minimum of 6–12 months after progression slowed and patient satisfied with results.
treatment started. improved scalp coverage. Patient must weigh benefits
vs. cost of long-term
treatment.
Symptom Monitoring Desired Outcome Actions
Excess hair shedding Monitor for increased shedding for Normal rate of hair loss If shedding does not resolve
2–8 wk after treatment started. (75–100 hairs per day) in 4–6 months after removal
Monitor for excess hair shedding within 4–6 months after of trigger or beginning of
(>300/day) for 1–3 months treatment started. therapy, patient requires
(possible diagnosis of telogen further assessment and/or
effluvium. See Pathophysiology). treatment.
Excess hair growth Monitor hair regrowth after removal. Cosmetically acceptable Cosmetic management of
Shaving, waxing, plucking, bleaching, appearance. excess hair is usually
depilatories: Monitor daily. required.
Laser therapy and electrolysis Topical anesthetics should be

procedures should be monitored for used with caution prior to
4–12 months. laser treatment. Serious
reactions should be assessed
and/or treated appropriately.
Skin irritation from Monitor daily for skin reactions to Minimal to no skin Stop using product. Treat
topical agents cosmetic treatment as well as irritation. symptomatically with low-
topical treatment. potency topical
corticosteroids.
Algorithms
Figure 1: Assessment and Management of Hair Loss
Figure 2: Assessment and Management of Excessive Hair Growth

Abbreviations: COCs = combined oral contraceptives; PCOS = polycystic ovary syndrome.
Drug Tables
Table 4: Therapy for Male- and Female-pattern Hair Loss (Androgenic Alopecia)a1,20,21,31
Class Drug Dosage Adverse Drug Comments Cost
5-Alpha-reductase dutasteride 0.5 mg Men: Combination Not a Health $

Inhibitors Avodart, daily Decreased with strong Canada–
Dutasteride, (some libido and CYP3A4 approved
other studies semen inhibitors indication.
generics have used volume, (e.g., No evidence for
up to 2.5 erectile ketoconazole, use in women
mg daily) dysfunction, ritonavir) may (a few case
headaches, increase reports only).
dry skin. serum
There is concentration
some of
concern that dutasteride.
due to Monitor for
dutasteride's increased
increased adverse
half-life reactions,
compared e.g., erectile
with dysfunction,
finasteride, decreased
side effects libido.
may
potentially be
more severe
or long-
lasting.
5-Alpha-reductase finasteride 1 mg daily Men: No known Limited $$

Inhibitors Propecia, po Decreased clinically evidence for
generics libido and significant use in women.
semen drug Can cause
volume, interactions. feminization of
erectile a developing
dysfunction, fetus;
headaches, contraindicated
dry skin. in pregnancy.
Concentration
in semen is
very low: no
risk to fetus via
sexual contact
of mother with
a male taking
finasteride.
Antifungals, azole ketoconazole 2% Uncommonly: No known Not a Health $

shampoo shampoo: Application clinically Canada–
Nizoral Lather in site irritation. significant approved
and leave drug indication.
on for 3–5 interactions Very limited
min before with topical evidence of
rinsing, use of efficacy (in
twice ketoconazole. combination
weekly to with
once every finasteride) but
2 wk little risk of
depending harm.
on
response
Piperidinopyrimidines, minoxidil 2% Apply 1 Scalp Not expected Apply to dry $$

topical solution mL (20 irritation, since scalp starting
Rogaine mg) BID itching, systemic at the centre of
Topical Total daily dryness, absorption is the affected
Solution dose not change in hair minimal. area.
to exceed colour. Avoid applying
2 mL (40 Temporary directly to the
mg) hair loss may hair as a
occur within greasy, flaky
Leave on the first 2–6
scalp for appearance
wk of use. can result.
at least 4 Discontinue if
h to lasts >2 wk.
maximize Systemic
absorption absorption is
minimal with
correct
application
and usual
doses.
Piperidinopyrimidines, minoxidil 5% Apply one- Scalp Not expected Massage lightly $$$
topical foam for half capful irritation, since into the
men (1g itching, systemic affected areas
Rogaine foam/50 dryness, absorption is of the scalp,
Foam mg change in hair minimal. avoiding direct
minoxidil) colour. application to
BID Temporary the hair.
Total daily hair loss may
dose not occur within
to exceed the first 2–6
2 g foam wk of use.
(100 mg Discontinue if
minoxidil) lasts >2 wk.
Systemic
Leave on absorption is
scalp for minimal with
at least 4 correct
h to application
maximize and usual
absorption doses.
Piperidinopyrimidines, minoxidil 5% Apply one- Scalp Not expected Massage lightly $$$
topical foam for half capful irritation, since into the
women (1 g itching, systemic affected areas
Rogaine foam/50 dryness, absorption is of the scalp,
Women's mg change in hair minimal. avoiding direct
Foam minoxidil) colour. application to
once daily Temporary the hair.
Total daily hair loss may
dose not occur within
to exceed the first 2–6
1 g foam wk of use.
(50 mg Discontinue if
minoxidil) lasts >2 wk.
Systemic
Leave on absorption is
scalp for minimal with
at least 4 correct
h to application
maximize and usual
absorption doses.
a
Cost of 30-day supply or smallest available pack size; includes drug cost only.
Legend: $ <$15 $$ $15–30 $$$ $30–45
Table 5: Therapy for Excessive Hair Growth in Women13,20,21,22,23,24

Antiandrogens cyproterone 25–100 Menstrual Metabolized by Not a Health Canada– $

acetate mg daily irregularities, CYP3A4, strong approved use.
Androcur, po × 10 decreased libido, inhibitors or May be used to treat
generics days nausea, inducers of this moderate to severe
(either depression, enzyme may alter hirsutism, including in
days 1– fatigue, weight levels and/or combination with
10 or 5– gain. effect of COCs.
15 of cyproterone.
menstrual
cycle)
Antiandrogens flutamide 250 mg Breast tenderness, May increase Not a Health Canada– $$$$
generics BID po menstrual anticoagulant approved use.
(study irregularities. effect of warfarin. May be used to treat
doses Risk of moderate to severe
have hepatotoxicity: hirsutism, including in
ranged Monitor liver combination with
from function COCs.
62.5–750
mg per
day)
Antiandrogens spironolactone 50–200 Mild diuretic, Increases serum Not a Health Canada– $
Aldactone, mg once lethargy, K+ when combined approved use.
generics daily po hyperkalemia, with ACE Commonly used to
hypotension, inhibitors, treat moderate to
breast tenderness, angiotensin severe hirsutism
menstrual receptor blockers, associated with
irregularities. K+ supplements, PCOS.
cyclosporine,
tacrolimus, other Sometimes combined
potassium-sparing with COCs for
diuretics. increased efficacy.
Contraceptives, ethinyl estradiol 1 tablet Major: May increase Considered first-line $

oral—combined 35 daily po × Thromboembolism cyclosporine levels treatment for general
ethinyl µg/cyproterone 2 21 days, (rare), stroke, or hepatotoxicity; hirsutism.
estradiol and mg off 7 days retinal artery may decrease Not a Health Canada–
antiandrogen Diane-35, and thrombosis, MI, lamotrigine levels. approved use.
generics repeat benign liver Significant
cycle tumour, pharmacokinetic Health Canada has
cholelithiasis, interaction with prepared a Suggested
hypertension. rifampin, prescriber/counselling
Watch for danger griseofulvin checklist for Diane-35
signals: ACHES— (advise backup and its generics25 to
abdominal pain, barrier method facilitate
chest pain, during therapy). documentation of
headaches, eye Monitor INR with discussion of risks.
problems, severe concurrent oral
leg pain. Advise anticoagulant use.
patient to consult Carbamazepine,
physician. modafinil,
Common: phenytoin,
Breakthrough protease inhibitors,
bleeding/spotting, phenobarbital, St.
amenorrhea, John's wort,
nausea/vomiting, topiramate may
bloating, decrease ethinyl
chloasma, breast estradiol/progestin
tenderness, mood serum
changes such as concentrations.
depression, Reports of COC
headaches. failure with
May increase risk concomitant
of VTE compared ampicillin,
with amoxicillin,
levonorgestreol- tetracycline,
containing COCs. erythromycin,
sulfamethoxazole/
trimethoprim or
nitrofurantoin.

ethinyl µg/drospirenone 21 days, (rare), stroke, or hepatotoxicity; hirsutism.
estradiol and 3 mg off 7 days retinal artery may decrease Not a Health Canada–
antiandrogen Yasmin, Zamine, and thrombosis, MI, lamotrigine levels. approved use.
Zarah repeat benign liver Significant
cycle tumour, pharmacokinetic
cholelithiasis, interaction with
hypertension. rifampin,
Watch for danger griseofulvin
signals: ACHES— (advise backup
abdominal pain, barrier method
chest pain, during therapy).
headaches, eye Monitor INR with
Common: phenytoin,
with amoxicillin,
sulfamethoxazole/
trimethoprim or
nitrofurantoin.

estradiol and 3 mg off 7 days retinal artery may decrease Not a Health Canada–
antiandrogen Yaz, MYA and thrombosis, MI, lamotrigine levels. approved use.
repeat benign liver Significant
cycle tumour, pharmacokinetic
Common: phenytoin,
with amoxicillin,
sulfamethoxazole/
trimethoprim or
nitrofurantoin.

estradiol and 3 off 7 days retinal artery may decrease Not a Health Canada–
antiandrogen mg/levomefolate and thrombosis, MI, lamotrigine levels. approved use.
calcium 0.451 repeat benign liver Significant
mg cycle tumour, pharmacokinetic
Yaz Plus cholelithiasis, interaction with
Common: phenytoin,
with amoxicillin,
sulfamethoxazole/
trimethoprim or
nitrofurantoin.

ethinyl µg/desogestrel 21 days, (rare), stroke, or hepatotoxicity; hirsutism.
estradiol and 0.15 mg off 7 days retinal artery may decrease Not a Health Canada–
minimally Marvelon, Apri, and thrombosis, MI, lamotrigine levels. approved use.
androgenic Freya, Mirvala, repeat benign liver Significant
progestin Reclipsen cycle tumour, pharmacokinetic
Common: phenytoin,
concomitant
ampicillin,
amoxicillin,
tetracycline,
erythromycin,
sulfamethoxazole/
trimethoprim or
nitrofurantoin.

ethinyl µg/desogestrel 21 days, (rare), stroke, or hepatotoxicity; hirsutism.
estradiol and 0.1 mg/0.125 off 7 days retinal artery may decrease Not a Health Canada–
minimally mg/0.15 mg and thrombosis, MI, lamotrigine levels. approved use.
androgenic Linessa repeat benign liver Significant
progestin cycle tumour, pharmacokinetic
Common: phenytoin,
concomitant
ampicillin,
amoxicillin,
tetracycline,
erythromycin,
sulfamethoxazole/
trimethoprim or
nitrofurantoin.
Insect Bites and Stings

Pathophysiology
Arthropods have exoskeletons, multisegmented bodies and paired, jointed appendages. Arthropods include spiders,
scorpions, ticks, fleas, lice, caterpillars, centipedes, ants, bees, wasps, mosquitoes and flies. Arthropods may bite (e.g.,
spiders, ticks, centipedes, mosquitoes, ants, black flies, horse flies) or sting (e.g., bees, wasps, fire ants, scorpions), emit a
toxic secretion (e.g., caterpillars) or have irritant hairs (e.g., some caterpillars or spiders).1 The most common injury when
coming into contact with arthropods is a localized, self-limiting skin reaction. Occasionally, serious sequelae can result from
systemic effects of envenomation or from significant allergic reactions. Deaths from arthropod exposures are rare in North
America and usually result from anaphylaxis.1
Spiders
Most spiders are venomous but few deliver sufficient venom in a human bite to cause systemic symptoms. Most spider
bites cause an initial stinging sensation followed by localized swelling, itching and inflammation.2 Spiders in the black
widow family (Lactrodectus species) can be found throughout the United States and in the western and southeastern
parts of Canada close to the US border.2 The bite of the black widow can lead to pain within 30–60 minutes followed by
sweating, nausea, blurred vision, muscle cramps, and swelling and redness at the site. Treatment is symptomatic.
Hospitalization may be necessary if more severe symptoms (tachycardia, chest pain, respiratory depression, infection at
the site) occur.2 The brown recluse spider is found in the Southeastern United States. Its bite can cause redness, itching
and pain within 6 hours. The venom contains enzymes that can cause tissue destruction; untreated bites can lead to
tissue necrosis.2
Ticks
Ticks attach to their victims with specialized mouth parts and feed until they are engorged with blood. The most common
reaction to tick bites is a red papule at the bite site, but swelling, blistering, bruising, itching or secondary skin infection
may develop.3
A number of different ticks can be carried by pets.3 Remove ticks from pets before they enter the yard or home. Removal
of ticks from pets is important to humans as ticks can carry diseases such as Lyme disease and Rocky Mountain spotted
fever.3,4 The risk to animals is minimal in most cases, but infection can occur if mouth parts remain in the skin of the
animal.
In Canada, the black-legged tick (deer tick) and the Western black-legged tick are the species known to carry the
spirochete Borrelia burgdorferi, which causes Lyme disease. Not all black-legged ticks carry Lyme disease but the number
is increasing. The black-legged tick is endemic in southeastern and southcentral Manitoba, parts of eastern, southern and
northwestern Ontario, southern New Brunswick, Grand Manan Island and a number of areas on the east coast of Nova
Scotia. The Western black-legged tick is endemic in the southern mainland of British Columbia and southern tip of
Vancouver Island. Health Canada maintains a map of current and predicted areas of concern (www.phac-aspc.gc.ca/id-
mi/tickinfo-eng.php).4,5 The tick must be attached to the skin for at least 36 hours to transmit the bacterium that causes
Lyme disease.4,6
Lyme disease typically presents with a rash called erythema migrans that expands outward from the bite site in a ring
pattern or bull's eye6 (see photo Lyme Disease Lesion). The rash can appear from 3–30 days after exposure. It begins at
the site of the bite and gradually becomes larger over several days. Flu-like symptoms such as fever, chills, lethargy,
fatigue and headache can occur.6 If left untreated, the infection can spread over several weeks and lead to more severe
symptoms such as Bell's palsy, severe headaches, neck stiffness and joint pain.6 If left untreated for several months,
more severe complications can occur; arthritis is the most common and neurologic complications (pain, numbness,
tingling and memory loss) are less common.4,6 Treatment with antibiotics can cure Lyme disease in most cases.
Antibiotics used for treatment are doxycycline, amoxicillin and cefuroxime axetil, and therapy continues for several
weeks.6
Photo 1: Lyme Disease Lesion

iStockphoto
A number of tick species (species depends on geographical area) carry the Rickettsia bacterium, which can lead to Rocky
Mountain spotted fever. In Canada, the Rocky Mountain wood tick is the major carrier of this disease and is found in
Western Canada. This disease is relatively rare but has been reported throughout the Americas including the United
States, Mexico, Panama, Costa Rica, Argentina, Brazil, Columbia and Bolivia. Prevalence in Canada is much less than that
of Lyme disease. The tick requires an attachment period between 4 and 6 hours to transmit the bacterium.7 Rocky
Mountain spotted fever is characterized by a sudden onset of fever, nausea, vomiting, headache and myalgias within 3
days.7,8 Two to five days after onset of fever, a maculopapular rash appears on the wrists and ankles, expanding over the
next 7 days along the extremities.7 Without treatment, patients may become severely ill and require hospitalization.
Doxycycline is the usual drug of choice for treatment, with tetracycline and chloramphenicol being alternatives.7
Prompt removal of ticks minimizes systemic reactions and risk of tick-borne diseases. See Nonpharmacologic Therapy
for information on how to remove a tick.
Mosquitoes
Biting insects such as mosquitoes deposit salivary secretions into the skin that commonly cause local histamine
reactions with redness, swelling and intense itchiness. Reddened, itchy papules develop within hours then subside slowly
over a few days. Some people may develop antibodies that contribute to formation of large welts that last several days.
Anaphylaxis is rare.9
A number of viral and parasitic diseases can be carried by infected mosquitoes, the most relevant in Canada being West
Nile virus. The Public Health Agency of Canada closely monitors and reports on West Nile virus, particularly in peak times
from May to October. West Nile virus infection has been reported in British Columbia, Alberta, Saskatchewan, Manitoba,
Ontario and Quebec. Reports outside these provinces are thought to be related to travel. West Nile virus can be
transmitted to humans via the bite of a mosquito that has previously fed on an infected bird. The virus can also be
transmitted through blood transfusions or organ/tissue transplants. There is evidence that pregnant women can pass the
virus to their unborn child. Transmission may also be through breast milk, though level of risk is unknown. The virus is not
known to be transmitted by touching or kissing between people or between animals and people.9
Many people infected with West Nile virus do not become sick. Symptoms usually appear within 2–15 days of being
infected. Mild cases present with flu-like symptoms (fever, body aches, headache) and possibly rash or swollen lymph
glands. Symptoms of more severe illness can include the sudden onset of headache, high fever, stiff neck, vomiting,
confusion and muscle weakness. Movement disorders, parkinsonism, polio-like syndrome and muscle degeneration can
also occur. Elderly, immunocompromised or chronically ill persons are more likely to become severely ill after being
infected; meningitis, encephalitis or acute flaccid paralysis can be fatal. There is no specific treatment for West Nile virus.
Patients with severe symptoms are managed with supportive therapy.9
Preventive measures (see Prevention) are especially important in areas of high risk and for those at risk of developing
severe illness.
Bed Bugs
Bed bugs feed on blood by piercing the skin, which can cause red itchy lesions at the location of the bite. Bites are
typically in clusters of 3–5 and may appear in a zigzag pattern. There may be tiny specks of blood on bedding or
pyjamas. Allergic reactions (redness, swelling, hives) can occur in some patients. Bed bugs are attracted to humans by
warmth and carbon dioxide. They generally feed just before dawn and hide during the daylight hours in seams of
mattresses, crevices in box springs or walls, or behind headboards. Adult bed bugs have an average life span of 6–12
months but are able to survive up to a year without feeding.10,11 Infestations of bed bugs are increasing, as is the interest
in whether bed bugs can transmit infections from one person to another. Although bed bugs are known to be carriers of
over 40 microorganisms and potentially plausible mechanisms for transmission have been identified, studies in HIV,
hepatitis B and methicillin-resistant Staphylococcus aureus have been unable to definitively state that bed bugs can act as
vectors of disease.12,13,14 One study suggested that severe infestations of bed bugs may lead to blood loss and
subsequent iron-deficiency anemia, particularly in high-risk populations (alcohol abuse, poor diet, cognitive impairment,
mental illness or poverty).15
Adult bed bugs are light yellow to reddish brown, oval shaped and approximately 5 mm in length. They are easily visible.
Using a magnifying glass to thoroughly check headboards, mattresses, box springs, baseboards, furniture and curtains
may be helpful to identify an infestation. Live bedbugs can sometimes be seen by using a flashlight just before dawn
when they are most active, but also larger and slow-moving due to feeding.11 See photos Bed Bug and Bed Bug
Infestation. Chemical repellents have not been proven to be effective for prevention of bed bug infestation or bites. It is
prudent to carefully check hotel rooms or new environments (seams of mattresses, crevices in box springs, behind
headboards, under baseboards and behind hanging pictures) or any garage sale or second-hand items brought into the
home. A combination of chemical pesticides (professionally applied) and nonchemical methods (vacuuming, application
of heat or steam for at least 2 hours, exposure to temperatures <–5ºC for at least 5 days, mattress encasements,
discarding of furniture) offers the best chance of eradication and must include follow-up confirmation.10,11
Photo 2: Bed Bug
Centers for Disease Control and Prevention
Photo 3: Bed Bug Infestation
Stinging Insects
Stinging insects of the order Hymenoptera, are known to cause the majority of severe insect-related reactions. There are 3
families of insects known to cause a reaction: bees (bumblebees, honeybees), vespids (yellow jackets, wasps and
hornets) and stinging ants (fire ants). The venom of bees and vespids contain multiple protein allergens which lead to a
severe reaction in those who are susceptible.16 The most common reaction to a sting from a hymenoptera insect is a
local reaction with an onset of 4–48 hours (pain, redness and swelling at site). Occasionally there may be an extensive
local reaction with swelling over a large area (e.g., the whole limb) peaking at 48 hours and subsiding over the next 3–10
days.16 Systemic reactions (headache, fever, nausea and vomiting within 12–24 hours) are more likely with multiple
stings from the same insect as well as repeated stings within a few months (same summer).16,17
The most serious reaction to insect stings is anaphylaxis, which can occur within minutes or up to 72 hours after the
initial sting.17 Systemic reactions can involve cutaneous, vascular and/or respiratory systems. The patient may initially
experience generalized warmth, flushing and itchiness. This can progress to hives, airway edema with throat tightness
and difficulty breathing, bronchospasm and, in severe cases, shock with hypotension.16 Venom immunotherapy (VIT)
greatly reduces the risk of developing severe systemic reactions in affected individuals18 (see Emergency Treatment).
Goals of Therapy
Prevent bites and stings
Prevent diseases or reactions caused by bites or stings
Ensure patient receives appropriate care when warranted in the case of more serious reactions
Provide symptomatic relief for localized reactions
Patient Assessment
Self-management is appropriate for most arthropod bites or stings in Canada because localized skin reactions (itching,
redness and swelling of bite area) are the most common consequence. Mild allergic reactions (hives, rash and mild swelling
at the bite site) can also be self-treated.1 Patients require further medical treatment if they experience extensive local
reactions (swelling beyond the bite site), multiple stings or an anaphylactic reaction (difficulty breathing, swelling of throat,
large areas of swelling, or fainting). Suspected anaphylaxis is a medical emergency and requires immediate treatment and
follow-up medical care. An assessment plan for patients with arthropod bites and stings is presented in Figure 1.
Prevention
Prevention of stings from stinging insects is accomplished by avoiding situations where the insect may feel threatened (e.g.,
near nesting areas, approaching hives, removal of nests) as stinging insects sting in self-defence.19 Preventive measures
include avoiding the use of scented cosmetics, perfumes and hairsprays that can attract insects, avoiding or using caution
when eating outdoors and ensuring that drinks are covered to avoid swallowing wasps or bees. Limiting the time spent
outdoors at dawn and dusk will also decrease the chances of a sting. Clothing that covers as much skin as possible and
tucking in pant legs when near nesting areas will also decrease the risk of being stung.20
Prevention of bites from biting insects can be accomplished by avoiding infested areas such as tall grasses, marshes,
swamps or bushy areas and avoiding being outdoors at dawn and dusk as mosquitoes are most active during these times.
Eliminating sources of standing water, such as rain barrels, clogged gutters and bird baths is the most effective way to
reduce the local mosquito population.20
To protect against ticks, pants and shirts should be tight at the ankles and wrists, or tucked into socks and gloves. Light-
coloured clothing makes ticks more visible for quick removal which will help to prevent attachment to the skin. This in turn
helps to prevent the transmission of disease and lessen local reactions. It is important when going indoors after possible
exposure to ticks to inspect clothing and tick-prone areas of skin such as the ankle, wrist and neck areas and quickly remove
if present.20
Use of mosquito netting and clothing that covers exposed areas of the body are recommended for infants less than 6
months of age and travellers to areas where mosquito-borne illness is endemic.9
Insect Repellents
Insect repellents can deter biting insects such as mosquitoes, black flies and ticks, but not stinging insects.20 Insect
repellents should be applied lightly directly to clothing and exposed skin, preferably outdoors or in a well-ventilated area.
The repellent should not be applied directly to the face (apply to the hands and then use hands to apply to face) nor
sprayed into or near the eyes or mouth. Avoid application to the hands of children who may then inadvertently transfer it
to their eyes or mouth. Repellent activity and duration of effect are highly variable, depending on the chemical and its
concentration, the individual's activity level, the environment and the insect.20 See Table 1 for more information on insect
repellents.
The insecticide permethrin can be used for protection against tick bites. Permethrin has insect repellent activity and
immobilizes ticks after ≤15 minutes of contact. It is sprayed directly onto clothing, tents or sleeping bags and the effect
can last for up to 20 washes. Permethrin spray is not available in Canada but permethrin-impregnated clothing can be
obtained from online retailers and is effective and long-lasting (no loss in effectiveness after 100 washes in one study).21
20,22,23,24
Table 1: Insect Repellents
Ingredient Action Dosage Adverse Comments
Effects
DEET Vapour thought to have Concentration: 5–30% Irritating to Second choice in

(N,N- offensive smell or taste to Apply sparingly to mucous children 6 months–
diethyl-m- insects and repels clothing or exposed skin membranes 12 y (icaridin 20%
toluamide) mosquitoes. according to Health and open first choice).
Effective against Canada guidelines: wounds. If travelling to area
mosquitoes, black flies, <6 months: Not Contact with high risk of
ticks, chiggers and fleas. recommended dermatitis arthropod-
(rash, redness, associated disease,
Duration of effect depends 6 months–1 y: ≤10%; itching) has
on concentration: maximum once daily up to 10% may be
been reported. applied to children
30% DEET = 5–8 h 2–11 y: 10%; maximum Absorbed <6 months.
20% DEET = 4–6.5 h TID through intact DEET ≤10% should
≥12 y: 5–30%; skin, and not be used for
15% DEET = 3.5–5.5 h
maximum TID systemic exposures longer
10% DEET = 2.5–4.5 h effects are
Available as lotion, than 1–2 h as it may
5% DEET = 1.5–2.5 h related to the not be effective in
pump and aerosol
amount preventing tick
sprays, towelette
absorbed. bites.
If ingested may Sunscreen should
lead to be applied first and
seizures, allowed to penetrate
hypotension, before DEET
angioedema or application.
death.
No evidence that the
use of DEET by
pregnant or
breastfeeding
women poses a
health hazard to
unborn babies or
breastfed
infants/children.
Avoid excessive or
prolonged use.
icaridin Believed to affect the Concentration: 10–20% Low toxicity. Icaridin (20%)
(also insect's ability to detect Apply directly to skin— Nonirritating to recommended as
known as the host by concealing avoid eye contact the skin, but first choice in
picaridin) attractants emitted by <6 months: Not should be kept children 6 months–
hosts or by changing the recommended out of eyes and 12 y.
insect's ability to smell mouth. If travelling to area
them. ≥6 months: Up to 20% with high risk of
No allergic
Effective against Reapply 10% after 5 h, reactions arthropod-
mosquitoes, ticks and up to QID reported. associated disease,
black flies. up to 10% may be
Reapply 20% after 7 h,
applied to children
Duration of effect: 10% = 5 up to BID
<6 months.
h for mosquitoes and 7 h Available as spray,
for ticks. No human data re:
aerosol or towelette
safety in pregnancy
20% = 7 h for mosquitoes and breastfeeding
and 8 h for ticks and (no toxicity seen in
blackflies. animal studies).
Ingredient Action Dosage Adverse Comments
Effects
p-menthane Effective against Concentration: 10% None known. Considered a

3,8-diol mosquitoes, biting flies <3 y: Not recommended second choice (first-
(PMD; oil of and gnats (not effective ≥3 y: Maximum BID choice: DEET or
lemon against ticks). icaridin) for ≥3 y.
Available as lotion
eucalyptus) Duration of effect is about
2 h.
oil of Thought to have an Concentration: 5–15% Low toxicity. Frequent

citronella offensive smell or taste to Apply to exposed skin Skin irritation reapplication
insects. as needed (redness, rash, needed.
Tested against <2 y: Not recommended itchiness) may Lack of safety data
mosquitoes only. occur. but no health risks
Available as lotion, associated with use.
Duration of effect is 20 spray or towelette Hypersensitivity
min to 2 h. reactions
possible.
soybean oil Thought to mask Concentration: 2% Very low No age restriction

attractants emitted by host Apply to exposed skin toxicity. on use.
and/or by cooling skin as needed Skin irritation
surface temperature. Available as mist/spray reported rarely.
Duration of effect is 1–4 h formulation Low potential
against mosquitoes and for
up to 8 h against black hypersensitivity
flies. reactions.
Effectiveness against ticks No systemic
approximately equal to absorption
DEET 10%. through skin.
First, remove the insect or stinger to decrease the local reaction. Stingers from the honeybee are barbed and remain
embedded in the skin. The stinger should be removed as soon as possible to stop the injection of venom into the wound.19
The stinger can be removed by gently scraping side to side with a fingernail, tweezers or credit card.17,19 The bite or sting
site should then be cleansed with warm water and soap to help prevent secondary infection. Ice or cool compresses applied
to the site provide symptomatic relief and reduce swelling.17 Home remedies such as baking soda poultices or toothpaste,
vinegar and salt applied to the site may relieve symptoms, but have not been well studied.17
Ticks are best removed by using tweezers25 that are able to grasp the tick close to where the head contacts the skin. It is
important to avoid twisting or pulling the tick out too quickly as this could cause the head to break off and remain in the skin.
Clean the area with soap and water once the tick has been completely removed as this will decrease some of the irritation at
the site.4
Products: Internal Analgesics and Antipyretics; Cough, Cold and Allergy Products; Insect Repellents; Skin Care Products: First
Aid.
A variety of treatments can be used to relieve symptoms from local reactions to bites and stings. For pain, consider usual
doses of oral analgesics such as acetaminophen, ASA or ibuprofen. Oral antihistamines are more effective than topical
products in relieving pain, itching and inflammation caused by insect stings.19 First-generation antihistamines (e.g.,
diphenhydramine, chlorpheniramine) and second-generation antihistamines (e.g., loratadine, cetirizine) are equally
effective in relieving the itching and inflammation from insect bites and stings. First-generation antihistamines tend to cause
more sedation and have a shorter duration of action than second-generation agents which must be considered when
recommending therapy.19 See Allergic Rhinitis for further information on antihistamines and doses to be used in treatment.
Topical products marketed for symptomatic relief of bites and stings may contain local anesthetics (e.g., benzocaine,
lidocaine, pramoxine), astringents (e.g., calamine, zinc oxide), counterirritants (e.g., camphor, menthol) or ammonia/baking
soda combination (e.g., Afterbite). Topical anesthetics reduce the conduction of sensory nerve impulses in the skin,
resulting in reversible loss of sensation. They have a short duration of action and give only minor relief immediately after the
sting or bite occurs.19 These products may provide temporary relief but evidence of effectiveness or comparative efficacy
among topical products is lacking. Apply as recommended (Table 3) for 2 or 3 days until the symptoms subside.26
Topical diphenhydramine is not recommended for the relief of itching as it can cause allergic contact dermatitis and
sensitization.19
Studies on the efficacy of topical corticosteroids for the treatment of insect bites and stings are limited but they may be
recommended to relieve the associated itchiness, swelling and redness.19,27,28 Table 3 provides more information on topical
antipruritics.
Emergency Treatment
Products: First Aid.
Anaphylaxis is a severe allergic reaction that occurs in those previously exposed to the allergen. It can be life-threatening and
requires immediate emergency attention. Symptoms can occur within minutes or up to several hours after exposure.
Respiratory reactions may appear as throat or chest tightness, cough or swelling of the tongue. Cutaneous reactions may
appear as hives or welts and severe itching, as well as flushing or redness of the skin. Gastrointestinal reactions may
manifest as difficult or painful swallowing, nausea, vomiting or abdominal cramping. Other reactions may include
lightheadedness, sweating or arrhythmias.29 Give epinephrine as soon as possible. Epinephrine alleviates symptoms by
reducing vasodilation and vascular permeability, decreasing bronchospasm, and enhancing coronary blood flow and blood
pressure. Transport the patient to hospital immediately. A second dose of epinephrine may be administered within 5–20
minutes if the patient has not responded adequately to the first dose. Up to 20% of insect bite anaphylactic reactions are
biphasic. The second reaction is most likely to occur within 4–6 hours of the initial reaction but the range is 1–30 hours.30
Oral antihistamines should not be used as first-line therapy in an emergency situation. They should be considered secondary
medication, to help with hives and itching.31 Epinephrine for self-injection is commercially available in various formats.
Information and complete instructions for use are found in the specific product monographs.
All patients who have reactions to venom should undergo allergy testing no sooner than 4–6 weeks after a sting; testing
earlier may cause a false-negative result.32 Immunotherapy with escalating doses of venom is effective in reducing
subsequent reactions.33
Table 2 provides a monitoring framework for management of arthropod stings and bites.
16,19,27,29
Table 2: Monitoring of Therapy for Insect Bites and Stings
Pain/fever Monitor for increased pain or Pain reduced to a Treatment with acetaminophen
fever daily for 7 days after bite tolerable level for the or ibuprofen (according to
or sting (monitor for signs of patient. recommended dosing). Patients
infection). No fever present. with significant symptoms past
Monitor the degree and duration 24–48 h (intolerable pain and
of pain and fever relief for high fever) or fever or pain that
effectiveness with each persists for >7 days require
analgesic dose. further treatment.
Pain should subside within 24 h.
Itching Monitor daily for degree and Itching reduced to a Treatment with topical
duration of relief with each tolerable level for the corticosteroids (according to
application. patient (does not recommended dosing), topical
Relief should occur within affect daily activities anesthetics up to QID or oral
minutes of treatment with or sleep patterns). diphenhydramine (according to
topical agents and within 1 h for recommended dosing).
oral agents. Patients with itching that persists
for >7 days despite appropriate
treatment, require further
assessment and/or treatment.
Swelling, redness Monitor daily for signs of Minimal swelling or Treatment with topical
increased swelling or redness at redness at site. corticosteroids (according to
site (signs of infection). recommended dosing), or oral
Swelling and redness should diphenhydramine (according to
subside within 24–48 h of bite recommended dosing).
or sting. Patients with extensive swelling
occurs (e.g., if whole limb is
involved) require further
assessment and/or treatment.
Local infection Monitor daily for up to 7 days No signs or Topical antibiotics can be used to
(unusual swelling, for signs of infection. symptoms of treat minor infection.
redness or infection. Patients with signs and
tenderness at bite symptoms of local infection that
site, pus or fever) do not respond to topical
antibiotics within 48 h require
further assessment and/or
treatment.
Suspected Monitor for signs and Symptoms subside Treat with epinephrine.
anaphylaxisa symptoms of anaphylaxis within and do not recur or All cases of suspected
30 min or less of exposure. worsen during 6 h of anaphylaxis require emergency
observation. medical attention.
a Mild: Generalized itching, flushing, hives, angioedema; Moderate: Dizziness, nausea, vomiting, abdominal cramps, chest or throat
tightness, hoarseness; Severe: Hypotension, breathing difficulties, hypoxia, confusion, incontinence
Algorithms
Figure 1: Assessment of Patients with Insect Bites and Stings

a Systemic symptoms: Generalized itching, flushing, sneezing, watery eyes, hives, nausea, vomiting, muscle cramps, dizziness,
fainting, hoarseness, lump in throat, difficulty breathing, changes in heart rate (faster or slower).
Drug Table
Table 3: Topical Therapy for Insect Bites and Stings19,26,28
Class Drug Dosage Mechanism of Adverse Comments Costa
Action Effects
Anesthetics, lidocaine 0.5–9.6%: Reduce the Skin irritation Lower $

topical Maxilene, Apply as conduction of and concentrations
(amides) Solarcaine, needed sensory nerve sensitization preferred for self-
Xylocaine Jelly, up to 5 impulses in possible but care. Avoid frequent
Xylocaine times the skin, uncommon application or
Ointment, daily; use resulting in when applied application to large
Xylocaine sprays no reversible loss correctly. Poor open wounds or
Viscous, more than of sensation. absorption large areas of
generics twice per through intact broken skin.
hour skin. Systemic Keep out of reach of
effects small children since
possible if methemoglobinemia
absorption can occur with
through open accidental ingestion.
skin.
Action Effects
Anesthetics, benzocaineb 7.5–20%: Reduce the Skin irritation Contraindicated in $

topical (esters) Anbesol, Apply conduction of and those with known
Lanacane TID–QID sensory nerve sensitization hypersensitivity.
Medicated PRN for impulses in possible but Keep out of reach of
Cream, Orajel itching; the skin, uncommon small children since
maximum resulting in when applied methemoglobinemia
7 days reversible loss correctly. Poor can occur with
of sensation. absorption accidental ingestion.
through intact
skin. Systemic
effects
possible if
absorption
through open
skin.
Anesthetics, pramoxinec 1%: Apply Reduce the Local irritation Avoid application $
topical (others) Aveeno Anti- QID PRN conduction of with burning, near eyes or nose.
Itch, Gold Bond sensory nerve stinging Preferred choice of
Medicated impulses in possible, topical anesthetic
Cream, Pramox the skin, especially of because of low
HC Cream, resulting in mucous potential for
Lotion, generics reversible loss membranes. sensitization and
of sensation. low toxicity.
No cross-
allergenicity with
esters or amides.
Corticosteroids, hydrocortisone 0.5%, 1%: Antipruritic Prolonged use Do not use if signs $
topical Cortate, Emo- Apply and anti- can cause of infection are
Cort, Prevex HC, TID–QID inflammatory. acneiform present.
generics PRN; eruptions, Caution with use
maximum irritation and near eyes or on any
7 days cracking of the areas of broken skin
skin. (including those
caused by
scratching).
Counterirritants camphor or 0.13– Cooling Skin irritation Lower concentration $

menthol- 10.5% sensation (burning, products preferred.
containing (most are from redness) at Do not apply to large
salves,d,e <1%): rubefacient higher areas of skin or
Apply effect. concentrations. open wounds.
sparingly Mild local Readily Keep out of reach of
PRN analgesia and absorbed small children
anti-itch through intact (especially high-
effects from and broken concentration
local irritant skin. Systemic products).
effect. toxicity
Irritants includes
stimulate local nausea,
sensory vomiting,
nerves headache,
reducing dizziness,
transmission tremors.
of pain
signals.
Action Effects
Protectants calamine lotion 1–16%: Skin Well tolerated, $

generics Apply protectants no
liberally and mild hypersensitivity
PRN astringents reactions, no
(reduce systemic
edema, absorption.
inflammation).
Soothing
effect on
irritated skin.
Others ammonia/baking 3.5% Localized Some skin Avoid exposure to $

soda ammonia: cooling effect irritation with eyes, mouth and
Afterbite Apply and relief of burning. mucous
sparingly itching Inhalation may membranes.
PRN cause sneezing Not recommended
and coughing. for children <2 y.
a
b Single-entity products are marketed for teething pain only, but could be used. Benzocaine is a component of some first aid products.
c No single-entity products available. Pramoxine is a component of some first aid products.
d Extemporaneously compounded preparations can be used.
e Camphor and/or menthol are components of many first aid products.
Legend: $ <$5
Suggested Readings
Government of Canada. For health professionals: Lyme disease. Available from: healthycanadians.gc.ca/diseases-conditions-
maladies-affections/disease-maladie/lyme/professionals-professionnels/index-eng.php.
Government of Canada. For health professionals treating West Nile virus. Available from:
http://healthycanadians.gc.ca/diseases-conditions-maladies-affections/disease-maladie/west-nile-nil-
occidental/professionals-professionnels-eng.php
Government of Canada. Insect repellents. Available from: healthycanadians.gc.ca/product-safety-securite-produits/pest-

control-products-produits-antiparasitaires/pesticides/about-au-sujet/insect_repellents-insectifuges-eng.php?
_ga=1.136545712.1489682248.1448374858.
Management of insect bites. Pharmacist's Letter/Prescriber's Letter 2008;24:240815.
References
1. Russell FE. Venomous arthropods. Vet Hum Toxicol 1991;33:505-8.

2. Quan D. North American poisonous bites and stings. Crit Care Clin 2012;28:633-59.
3. University of Guelph. Pest Diagnostic Clinic. Ticks of Eastern Canada. Available from:
www.guelphlabservices.com/files/PDC/003Ticks.pdf. Accessed August 7, 2014.
4. Government of Canada. For health professionals: Lyme disease. Available from: healthycanadians.gc.ca/diseases-
conditions-maladies-affections/disease-maladie/lyme/professionals-professionnels/index-eng.php. Accessed
August 7, 2014.
5. Public Health Agency of Canada. Public health reminder: Lyme disease. Available from: www.phac-aspc.gc.ca/phn-
asp/2015/lyme-eng.php. Accessed October 19, 2015.
6. Centers for Disease Control and Prevention. Lyme disease. Available from: www.cdc.gov/lyme/. Accessed August 7,
2014.
7. Dantas-Torres F. Rocky Mountain spotted fever. Lancet Infect Dis 2007;7:724-32.
8. Public Health Agency of Canada. Infectious Diseases. Rickettsia Rickettsii Available at: http://www.phac-
aspc.gc.ca/lab-bio/res/psds-ftss/rickettsia-rickettsii-eng.php. Accessed April 20, 2016.
9. Government of Canada. West Nile virus. Available from: healthycanadians.gc.ca/health-sante/disease-maladie/wnv-
vno-eng.php. Accessed October 10, 2015.
Minor Cuts and Wounds

Pathophysiology
A wound is a disruption in the normal skin structure and functioning due to mechanical trauma and injury.
Partial-thickness wounds affect the epidermis and outer dermal layers, while deeper, full-thickness wounds
penetrate through the subcutaneous tissues (fat layer) exposing structures such as muscle or bone.1 Blunt
trauma can produce a superficial bruise or deeper hematoma as a result of leakage of blood from small
venules and arterioles.2
Wounds are classified as acute or chronic:
Acute wounds can occur from burns, bites, abrasions, scrapes, minor lacerations and punctures, and
acute wounds tend to heal quickly with minor treatment
Chronic wounds occur when healing has been delayed or impaired due to various conditions (e.g.,
immunocompromised states, diabetes) or have not proceeded through the healing process correctly.1
This chapter does not discuss management of chronic wounds. See Atopic, Contact, and Stasis
Dermatitis and consult the Compendium of Therapeutic Choices: Pressure Ulcers and Diabetic Foot
Infections.
Wound healing begins at the time of injury and generally proceeds through 3 phases:
The first phase is the inflammatory phase which begins at the time of injury and lasts up to 6 days.
This phase is characterized by the release of inflammatory mediators resulting in vasoconstriction,
redness, pain, platelet aggregation and clot formation, and manifests as redness, edema and a higher
level of drainage from the wound1
The second phase is the proliferative phase which lasts from 4–24 days depending on the type of
wound, cause and depth. This phase is characterized by the formation of new tissue, wound
contraction and the formation of new epithelium; the wound remains red and raised
The third and final phase is the maturation phase. Within 4–5 days of injury, collagen forms early scar
tissue that holds the wound edges together and strengthens it.2,3 Collagen continues to strengthen the
wound for up to 2 years depending on the type of wound.1 Minor wounds usually heal without scarring.
Large or deep wounds may leave a visible ridge or puckering of excess collagen at the healed wound
site.
Wound Complications
The most common complications of wounds are infection and scarring.
Infection
All wounds are contaminated with bacteria to some extent, and infection is possible if the wound is
not dealt with appropriately and promptly. Gram-negative and gram-positive bacteria (including
tetanus) and fungi may be involved in wound infections. Infection with Clostridium tetani (found in
soil) via a contaminated wound can be fatal. Patients with wounds that are unclean should be given a
tetanus vaccination to prevent infection with this bacterium if their vaccination status is not
adequate (see Pharmacologic Therapy).1
Minor infection presents with redness, inflammation, tenderness to touch and warmth in the
immediate area of the wound. Other symptoms of wound infection may appear as discharge, delayed
healing, abnormal odour, wound breakdown and increased pain.1 These symptoms may indicate a
more serious infection.
Wound factors that may increase the risk of infection include:1,2
Presence and type of foreign matter in the wound (débridement removes dead or contaminated
material that can harbor bacteria)
Location of the wound (near a site of potential contamination such as the anal area); one study
also found wounds on the lower extremities to be at higher risk of infection4
Injury to underlying structures such as bone or muscle (deep wound that is difficult and slow to
heal and at higher risk of bacterial invasion and infection)
Presence of devitalized tissue (increases the risk of harbouring bacteria in the wound)
Although historically it was believed that wounds that were closed (sutured) >12 hours after
time of injury were more likely to become infected, there is some evidence that time lapse
before wound closure is not as important as previously thought.4
Patient factors related to infection risk include:1,2
Age (epidermis and subcutaneous layer become thinner with increased age)
Underlying medical conditions (e.g., diabetes can affect wound healing if there is poor glycemic
control and presence of peripheral vascular disease)
Malnutrition (deficiencies of protein, zinc and vitamins A and C may slow or impair the healing
process)
Smoking
Drug therapy (e.g., long-term corticosteroid use inhibits cell growth, chemotherapy medications
may affect the immune system and delay healing, anticoagulants slow the clotting rate and
increase the healing time of wounds).
Scarring
Scarring occurs when there is a large deposit of collagen and glycoprotein at the wound site and is a
natural part of the healing process. Moist healing environments have been shown to decrease the
extent of scarring and improve the healing of wounds by accelerating inflammatory and proliferative
phases of repair.5 Discoloration can occur if the area is exposed to the sun, but can be decreased
with the use of sunblock for up to 6 months after the injury heals.1 Silicone gels and sheets applied
topically hydrate the scar and are used for 3–6 months.6
Goals of Therapy
Provide an environment that optimizes wound healing and prevents cosmetic deformity
Prevent infection
Minimize further trauma to the area
Minimize patient discomfort
Patient Assessment
Superficial wounds that are small and accompanied by limited bleeding are suitable for self-management.
Patients require further assessment and/or treatment in the following situations: wounds that continue to
bleed, deep puncture wounds, gaping wounds, wounds that expose fat, muscle or bone, animal bites,
wounds with visible foreign material or dirt, wounds causing severe pain, wounds in patients with underlying
medical conditions or drug therapy that puts them at risk of infection or delayed healing (see Wound
Complications), and those with large, complicated or chronic wounds.2 See Figure 1.
Self-treatment of minor wounds includes the following steps:
1. Cleanse the wound: Remove dirt and debris from the wound as soon as possible to prevent infection
and promote healing.1 Once debris has been removed, carefully wash the wound with water. Drinkable
tap water is as effective for wound cleaning as saline or purified water, with no increased risk of
infection or decrease in wound healing7 [Evidence: SORT A]
2. Stop the bleeding: Apply a clean dressing or gauze to the wound area for 10 minutes. If the bleeding
does not stop within 10 minutes (or 15 minutes if anticoagulated) the patient should seek emergency
medical attention. Monitor those on anticoagulants for up to 15 minutes, as the clotting time will be
longer, and refer if the bleeding does not stop within that time period. Visible pieces of dirt or other
foreign material that remain after irrigation can be gently picked out of the wound with tweezers that
have been cleaned with rubbing alcohol, or by brushing gently with clean gauze. These steps protect
the wound from infection and tissue destruction and help the wound to heal faster1
3. Apply a dressing: Choose a dressing that maintains a moist wound bed (see Dressings) to protect the
wound from possible infection and improve the healing process. Minor cuts, paper cuts or skin cracks
can be closed using tissue adhesives or liquid bandage. Larger cuts, where the edges won't stay
together, the edges are jagged or the wound is deep, may need stitches.
Débridement: The removal of foreign material such as dead or contaminated tissue from the wound should
be performed only by an appropriately trained healthcare practitioner and under sterile conditions.1
Cleansing and Antiseptic Agents
Use of antiseptics is appropriate only when the risk of infection is high (see Wound Complications). They
should be applied only around the wound area, not directly onto the wound (see Table 1).
Ailments—Skin Care Products: First Aid.
1,8,9,10,11
Table 1: Cleansing and Antiseptic Agents
Treatment Uses Advantages Disadvantages
Saline solution Cleansing agent for Not harmful to tissue. Not always available;
the initial removal of drinkable tap water is just
dirt and debris from as effective for cleansing
a wound. wounds.7
Hydrogen An oxidizing agent Effervescent action May cause tissue toxicity

peroxide 3% that has antiseptic, cleanses wounds. and impair wound healing
disinfectant and Has some mild through irritation of the
deodorant antibacterial activity. tissue and destruction of
properties used to regenerating epithelium.
clean wounds. Has limited bactericidal
effect.
Little benefit over soapy
water.
Treatment Uses Advantages Disadvantages
Isopropyl alcohol Bactericidal in Can decrease Not to be used on open

70% concentrations of bacteria counts for wounds.
70–90% and used 20–40 min after High potential for drying
as a disinfectant for contact. the skin.
wounds and prior to Some fungicidal
injections. Irritating to tissue.
activity.
Iodine Used as a Aqueous solution is Stains skin and clothing.

disinfectant and preferable as it is less May irritate tissue and
antiseptic for irritating and drying impair wound healing.
contaminated than alcohol base.
wounds, wound bed May cause allergic
management and sensitization.
prevention of
infection.
Povidone-iodine Used as a Nonirritating to skin. Contraindicated in

disinfectant and Rapid bactericidal patients with iodine
antiseptic for activity. allergy.
contaminated May be absorbed
wounds and pre- Broad-spectrum.
systemically: can be
operative harmful if used on large
preparation of the areas or for prolonged
skin. periods of time. Use with
caution in patients with
thyroid disorder.
Infection and tissue
damage increased if used
in combination with
surfactants.
May impair wound
healing.
Topical Antibacterials
Prophylaxis: Topical antibiotics are recommended for prevention of complications in wounds that are at
higher risk of becoming infected (see Wound Complications), improperly cleansed wounds or chronic
wounds.12 Evidence shows that use of topical bacitracin13 and bacitracin/neomycin/polymyxin B
combination13,14 result in significantly lower infection rates than plain petrolatum or placebo ointment
for minor wounds. Antibacterial bandages have not been proven to be more effective for wound care
than regular bandages and are more expensive.12 Silver sulfadiazine was previously believed to play a
role in reducing microbes in wounds. However, despite limitations in available evidence, there appears to
be a risk of delayed wound healing associated with silver sulfadiazine, and alternative wound regimens
should be considered when feasible.15
Treatment: Superficial, mildly infected wounds (see Wound Complications) may be treated with topical
antibiotics such as fusidic acid, mupirocin or various combinations of bacitracin/gramicidin/polymyxin
B/neomycin.16,17 There is insufficient evidence to recommend one topical antibiotic over another except
in the case of methicillin-resistant Staphylococcus aureus (MRSA) infection where mupirocin is
recommended.18 Consider topical antibiotics only when medically necessary and use responsibly to
prevent resistant strains from developing.19 If used, discontinue as soon as signs and symptoms of
infection are no longer present. Consider further assessment and/or treatment if clinical improvement is
not evident within 3–5 days of topical antibiotic therapy or if signs and symptoms of infection worsen at
any time.
More information on topical antibacterials can be found in Table 3.
Other Therapy
Systematic reviews have determined that evidence is inconclusive regarding whether aloe vera gel20 or
topical honey21 improve outcomes for acute wounds. Some patients experience mild side effects of
burning sensation, contact dermatitis or mild itching with topical application of aloe vera.22
Prevention of wound infection with oral antibiotics is generally recommended only in cases of animal or
human bites, deep puncture wounds and wounds involving the palms and fingers.17 Treatment of wound
infections with oral antibiotics is recommended for infections involving deeper tissues (including
puncture and bite wounds)17 and may also be considered if an infection persists for more than 2 weeks
with topical antibiotic use and correct wound management.1 For further information on use of oral
antibiotics in the treatment of bacterial skin infections, consult the Compendium of Therapeutic Choices:
Bacterial Skin Infections.
Tetanus is a potential complication of any wound in those whose tetanus immunization is incomplete or
has lapsed.12,17 Even patients with apparently minor, clean wounds should receive a tetanus booster if:
their immunization is incomplete (less than 3 doses), they are uncertain when they received their last
tetanus shot or their last tetanus shot was more than 10 years ago. Patients with dirty or complicated
wounds require tetanus prophylaxis if more than 5 years have elapsed since their last tetanus booster.12
Consider rabies vaccination in cases of bites from unprovoked animal attacks, especially where wild
animals such as raccoons, skunks, foxes or bats are involved.3
A monitoring plan for patients with minor cuts and wounds is provided in Table 2.
Table 2: Monitoring of Therapy for Minor Cuts and Wounds

Sign/Symptom Monitoring Endpoint Actions
Bleeding Monitor bleeding: Bleeding significantly Patient requires

Should stop within 10 slows or stops within emergency medical
min (15 min if on 10–15 min of direct treatment if blood is
anticoagulants). pressure. spurting or significant
bleeding persists after
10 min of direct
pressure (15 min if
anticoagulated).
Infection, e.g., Monitor daily at No signs or Assess for further

swelling, surrounding dressing change for at symptoms of infection treatment if signs and
redness that is tender least 48 h. present at 48 h. symptoms of
to touch, red streaks infection are present
from the wound, pus at or before 48 h.
or fever
Sign/Symptom Monitoring Endpoint Actions
Wound healing Monitor daily at Normally, healing If wound continues to

dressing change for wounds appear pink weep, remains raw
4–14 days (depending or red with tiny and red or does not
on wound type, depth opalescent islands of appear to be closing
and location). epithelium throughout within 2–4 wk, further
and no drainage. assessment is
required.
Algorithms
Figure 1: Assessment of Patients with Minor Acute Wounds
a
See Burns.
Drug Table
Table 3: Topical Antibacterials for Minor Cuts and Wounds
Effects
Antibacterials, bacitracin Apply Common: Spectrum: $

miscellaneous generics daily– Localized Mostly
TID itching and gram-
burning. positive,
Relatively minimal
common gram-
sensitizer. negative.
Common
co-reactions
with
neomycin
(not a true
cross-
reaction).
Possible
cross-
reaction
with
polymyxin
B.
Resistance
uncommon
but can
develop
with
prolonged
use.
Antibacterials, fusidic acid Apply Dryness, Spectrum: $$$

miscellaneous Fucidin BID– itching, Gram-
TID burning, positives.
local
irritation.
Antibacterials, mupirocin Apply Dryness, Spectrum: $$

miscellaneous Bactroban, generics BID– itching, Gram-
TID burning, positives
local including
irritation. some
strains of
MRSA
(resistance
is
developing).
Effects
Antibacterial bacitracin/gramicidin/polymyxin Apply Common: Spectrum: $

combinations B daily– Localized Gramicidin:
Polysporin Products, generics TID itching and Gram-
burning. positives.
Bacitracin Polymyxin
component B: Gram-
is a negatives.
relatively Ingredients
common are
sensitizer. combined
to provide
broad
antibacterial
coverage.
Resistance
uncommon
but can
develop
with
prolonged
use.
Antibacterial bacitracin/neomycin/polymyxin Apply Common: Spectrum: $

combinations B daily– Localized Neomycin:
Neosporin Ointment, generics TID itching and Gram-
burning. positives
Bacitracin and gram-
component negatives.
is a Ingredients
relatively are
common combined
sensitizer. to provide
broad
antibacterial
coverage.
Resistance
uncommon
but can
develop
with
prolonged
use.
a
Cost of 15 g; includes drug cost only.
Legend: $ <$5 $$ $5–10 $$$ $10–15
Suggested Readings
Canadian Association of Wound Care. Available from: www.cawc.net.
Dufour A. Wound care. CE lesson. Pharmacy Practice 2007;CE1-8.

Health Canada. First Nations and Inuit Health Branch (FNIHB) Clinical Practice Guidelines for Nurses in
Primary Care. Adult care. Chapter 9. Skin. Dermatological emergencies. Skin wounds of traumatic origin.
Available from: www.hc-sc.gc.ca/fniah-spnia/services/nurs-infirm/clini/adult/skin-peau-eng.php#sw1.
Singer AJ, Dagum AB. Current management of acute cutaneous wounds. N Engl J Med 2008;359:1037-46.
References
1. Dufour A. Wound care. CE lesson. Pharmacy Practice 2007;CE1-8.

2. Lammers RL. Principles of wound management. In: Roberts JR, Hedges JR, eds. Clinical procedures
in emergency medicine. 3rd ed. Philadelphia: Saunders; 1998. p. 533-9.
3. Eastman SR. Basics of wound care. US Pharm 1996;21:91-8.
4. Quinn JV, Polevoi SK, Kohn MA. Traumatic lacerations: what are the risks for infection and has the
“golden period” of laceration care disappeared? Emerg Med J 2014;31:96-100.
5. Korting HC, Schollmann C, White RJ. Management of minor acute cutaneous wounds: importance of
wound healing in a moist environment. J Eur Acad Dermatol Venereol 2011;25:130-8.
6. Shields K. Scar reduction products. Pharmacist's Letter 2004;20(200704).
7. Fernandez R, Griffiths R. Water for wound cleansing. Cochrane Database Syst Rev 2012;2:CD003861.
8. Pray S. Caring for minor wounds. US Pharm 2006;31:16-23.
9. Sweetman SC, ed. Martindale: the complete drug reference. 35th ed. London: Pharmaceutical Press;
2007.
10. World Wide Wounds. Collier M. Recognition and management of wound infections. Available from:
www.worldwidewounds.com/2004/january/Collier/Management-of-Wound-infections.html.
Accessed August 7, 2014.
11. Sibbald RG, Orsted HL, Coutts PM et al. Best practice recommendations for preparing the wound
bed: update 2006. Wound Care Canada 2006;41:15-29. Available from:
cawc.net/images/uploads/wcc/4-1-vol4no1-BP-WBP.pdf.
12. Health Canada. First Nations and Inuit Health Branch (FNIHB) Clinical Practice Guidelines for Nurses
in Primary Care. Adult care. Chapter 9. Skin. Dermatological emergencies. Skin wounds of traumatic
origin. Available from: www.hc-sc.gc.ca/fniah-spnia/services/nurs-infirm/clini/adult/skin-peau-
eng.php#sw1. Accessed April 14, 2016.
13. Dire DJ, Coppola DO, Dwyer DA et al. Prospective evaluation of topical antibiotics for preventing
infections in uncomplicated soft-tissue wounds repaired in the ED. Acad Emerg Med 1995;2:4-10.
14. Maddox JS, Ware JC, Dillon HC. The natural history of streptococcal skin infection: prevention with
topical antibiotics. J Am Acad Derm 1985;13:207-12.
15. Wasiak J, Cleland H, Campbell F et al. Dressings for superficial and partial thickness
burns. Cochrane Database Syst Rev 2013;3:CD002106.
16. Lipsky BA, Berendt AR, Deery HG et al. Diagnosis and treatment of diabetic foot infections. Clin
Infect Dis 2004;39:885-910.
17. Worster B, Zawora MQ, Hsieh C. Common questions about wound care. Am Fam Physician
2015;91:86-92.
18. Liu C, Bayer A, Cosgrove SE et al. Clinical practice guidelines by the infectious diseases society of
America for the treatment of methicillin-resistant Staphylococcus Aureus infections in adults and
children. Clin Infect Dis 2011;52:1-38.
19. Elston DM. Topical antibiotics in dermatology: emerging patterns of resistance. Dermatol Clin
2009;27:25-31.
20. Dat AD, Poon F, Pham KB et al. Aloe vera for treating acute and chronic wounds. Cochrane Database
Syst Rev 2012;2:CD008762.
21. Jull AB, Cullum N, Dumville JC et al. Honey as a topical treatment for wounds. Cochrane Database
Syst Rev 2015;3:CD005083.
22. Combest WL. Aloe vera. US Pharm 2000;25:64-74.

Parasitic Skin Infections: Lice and Scabies

Lice (Pediculosis)
Pathophysiology
Lice are tiny, blood-sucking insects that are specific parasites of humans. Outbreaks in institutions such as schools and long-term
care facilities are common with an estimated prevalence of 1–3% in elementary school-aged children.1 Three species of lice exist:
head lice (Pediculus humanus capitis), body lice (Pediculus humanus corporis) and pubic lice (Phthirus pubis or “crabs”).
Lice are 1–4 mm long with 3 pairs of legs that end with claws. Head and pubic lice live on the skin, whereas body lice live in the
seams of clothing. The adult female life cycle is up to 30 days and she lays 7–10 eggs daily. The body louse lays her eggs in
clothing, while head and pubic lice lay their eggs at the base of hair shafts, cemented to the hair in egg casings called nits. Eggs
hatch 8–10 days later and undergo 3 nymph stages to eventually mature into adult forms within 8–15 days (head and body) or 14–
22 days (pubic). Lice are obligate human parasites and survival time off the human host varies: 4 days for head lice, 3 days for
body lice, and 3 days for pubic lice. Female lice can mate and begin to lay viable eggs approximately 1.5 days after becoming
adults. Nits can survive away from the human host for up to 10 days. In contrast to head and pubic lice, the body louse is a vector
of human diseases such as typhus, relapsing fever, trench fever and endocarditis.
Transmission of head lice is by hair-to-hair contact and by fomites such as clothing or hair accessories. Pubic lice are transmitted
via sexual or close body contact and fomites such as bed linens and towels. Body lice move from host to host only through shared
clothing and linens. Poor hygiene has a major role only in the epidemiology of body lice.2,3,4,5,6
Head Lice
Pruritus, particularly around the back and sides of the scalp, is the main symptom of lice infestation. Physical examination of
the scalp should detect nits (eggs) attached to the base of hair shafts in the warmer parts of the scalp (back and sides). The
height of the nits above the scalp indicates how long the infestation has been present on the growing hair. Itchy papules can
develop as a hypersensitivity reaction to the louse saliva or fecal material. Secondary bacterial infection may occur as a result
of scratching.2,3,4,5,7
Body Lice
The body louse lives and lays eggs in the seams of clothing and usually emerges at night to take a blood meal from the host.
Consequently, nocturnal pruritus is a common symptom. Erythematous papules with a central puncture point (bite sites) are
evident often around the waist and axillae where seams of clothing contact the skin. Occasionally, bite sites reveal sky-blue or
slate-coloured macules known as maculae ceruleae, the result of injected louse anticoagulant saliva during feeding.
Hypersensitivity reactions to the bites can develop and the resultant pruritus is accompanied by excoriations that may become
secondarily infected. Lice and eggs are found in clothing seams.2,3,4,5
Pubic Lice
Nits attached at the base of pubic hair follicles are more difficult to find than those of head lice. The lice may appear as small,
yellow-brown to grey dots. Small brown specks on undergarments result from lice excreta. With heavy infestations, bite sites
may reveal a blue-gray skin discoloration (maculae ceruleae). Pruritus in the genital area is the main symptom; hypersensitivity
reactions and secondary infections are also possible.
Eyelashes, eyebrows, beards and other hairy areas can also be infested with pubic lice. Itching, burning and eye irritation can
occur when the eyelashes are involved.2,3,4,5,8
Goals of Therapy
Exterminate head, body or pubic lice
Relieve pruritus
Prevent spread of the infestation
Patient Assessment
Patient Assessment
Patients with recurrent or unresponsive head lice or pubic lice require further assessment and/or treatment by an appropriate
healthcare practitioner. Characteristics of the 3 types of lice are compared in Table 1.
4,9
Table 1: Assessment of Lice
Characteristic Head Lice Body Lice Pubic Lice
Type of primary Papules Papules Papules

lesions
Type of secondary Excoriations, crusts; pustules Linear excoriations, crusts; Excoriations, crusts; blue-grey
lesions with secondary infections pustules with secondary pigmentation; pustules with
Enlarged cervical and nuchal infections secondary infections
lymph nodes
Distribution of Scalp Waist and axillae (trunk) Pubic area (uncommonly,

lesions and pruritus eyelashes, eyebrows, beard or
axillae)
Presence of lice or Scalp hair Seams of clothing Pubic hair (also eyelashes,
nits eyebrows, beard or axillae)
Transmission Head-to-head contact; sharing Clothing or bedding; Sexual exposure to an

hats or combs conditions of poor hygiene infected person
Differential diagnosis Dandruff Seborrheic dermatitis Seborrheic dermatitis

Seborrheic dermatitis Flea bites or other insect Folliculitis
Accumulation of hair bites Dermatophytosis
cosmetics Eczema
Impetigo
Folliculitis
Host Children Persons with poor hygiene Sexually active adults
The diagnosis of head lice is established by identifying live lice, which can be difficult since lice crawl quickly and avoid light. The
most reliable method of detecting head lice is called “wet combing with conditioner”.10,11
This method requires that white coloured hair conditioner is maximally applied to all of the hair, first combing from the base of the
hair to the end with a regular comb, then with a nit comb. The remaining material in the comb should be checked for live lice which
should be discarded in tissue; the combing procedure should be repeated 5 times for each area of hair.12
Contact with infected persons promotes the spread of the infestation. Avoid sharing personal items such as clothing, combs, hats
and bedding of an infected person.
Clothes, linens, scarves and hats should be dry cleaned, washed in hot water and dried in the hot cycle for 15 minutes, or stored in
plastic bags for 2 weeks. Furniture should be vacuumed. Combs and brushes should be soaked in hot water for 5–10 minutes or
washed with a pediculicide shampoo.4,7,11,13
A combing method known as “bug busting” requires combing of wet hair for 30 minutes every third or fourth day using a fine-
toothed comb, for 2 weeks. This method is considered unfeasible on a widespread basis but may be an option for motivated
caregivers of children with short, straight or wavy hair. Trials comparing wet combing with placebo, permethrin or malathion as a
primary treatment for head lice have yielded conflicting results, possibly because of varying insecticide resistance.9,14,15,16
It is well known that body lice die via desiccation when exposed to hot air (51°C) for 5 minutes. In an attempt to use this method
for the treatment of head lice, the LouseBuster was developed. It is a high-volume, hot-air blower with a hand piece supporting a
coarse-tooth comb device. One trial investigated 6 methods of delivery of hot air treatments and found the LouseBuster to be the
most effective.17 One 30-minute application of hot air resulted in nearly 100% mortality of eggs and 80% mortality of hatched lice.
However, since only 11 children treated with this method had follow up and subjects with a high probability of reinfestation were
excluded, valid conclusions on clinical effectiveness cannot be made. The machine is expensive and requires special training to
use.18 A regular blow dryer should be avoided as it can cause live lice to be airborne and spread to others nearby.19
The best choice of a pediculicide depends on local resistance patterns, safety considerations and ease of administration. See
Table 5 for more information.
Products: Pediculicides.
Head Lice
The insecticides permethrin and pyrethrins with piperonyl butoxide and the physically acting agents isopropyl
myristate/cyclomethicone and dimeticones (dimethicones) have demonstrated efficacy and lack of toxicity in the treatment of
head lice.14,16 Table 5 provides information on the mechanism of action, precautions, directions for use, efficacy, safety and
adverse effects of these 4 treatments for head lice. Lindane is also an effective pediculicide; however, there are concerns about
possible neurotoxicity, bone marrow suppression and carcinogenicity following percutaneous absorption.4,32,33 Lindane is no
longer available in Canada.
Family members and close contacts should be examined and treated if infested. Bed mates should be treated
prophylactically.7,11,34
After treatment, nits will remain attached to the hair. The female louse secretes a cement-like fixative to hold her eggs in place
on the hair strand. This fixative material works as a simple holdfast and not a chemical adhesive. To loosen louse nits,
lubricants such as hair conditioners can assist in sliding the eggshells along the hair shaft. Commercial nit removal products
have no proven efficacy.35,36 Several other methods of removing nits have been suggested. The glue by which nits are attached
can be loosened by soaking the hair with white vinegar (3–5% acetic acid), wrapping the hair in a towel (soaked in the vinegar)
for 30–60 minutes and rinsing with water afterwards. Although the clinical benefit has not been documented,31 the nits may
then be more easily removed with a fine-toothed metal nit comb.5
The “no-nit” policy requiring children be free of nits before returning to school has not been effective in mitigating outbreaks.
Consequently, it is recommended that parents of an affected child be notified, and that the child not be sent home early but
receive treatment with an effective pediculicide that evening, and return to school the next morning.7,11,20,34
Head Lice Treatment Failures
Treatment failure can occur due to misdiagnosis, improper use of pediculicide (e.g., hair not saturated from scalp to ends or
product not left on hair long enough), not repeating the treatment after 7–10 days, reapplication too soon after initial
application, inadequate manual removal of nits, repeated exposure to lice (reinfestation) or resistance to a pediculicide.
Some pediculicides rely on neurotoxic effects to kill lice. Resistance to pyrethrins and permethrin has developed in
countries with heavy pediculicide usage such as France, Czech Republic, Ireland, the United Kingdom and the United
States.37 Formal collection of resistance patterns has not been done in Canada so the prevalence of resistance is unknown.
In countries with documented resistance, the appropriate choice has been dependent on local resistance patterns, which
continue to change.38,39,40
When a properly applied treatment fails, try switching to a product of a different pharmacologic class.3 A number of
alternative therapies have been investigated for difficult cases unresponsive to the usual agents. Permethrin 5% cream
(officially indicated only for scabies treatment) left on the hair overnight covered with a plastic shower cap41 or oral
ivermectin 200 µg/kg repeated in 7–10 days42 (available through the Special Access Programme in Canada) or the
combination of oral sulfamethoxazole/trimethoprim (10 mg/kg per day of trimethoprim usually twice daily for 10 days)
plus permethrin 1% applied for 10 minutes on day 1 and day 7 may be effective for cases resistant to all topical
pediculicides.43 Ivermectin is not recommended in children weighing <15 kg.6 Itching does not necessarily mean that a
reinfestation has occurred. Itching can be caused by an inflammatory response to the pediculicide and may persist for
several days after treatment. An oral antihistamine or low-potency topical corticosteroid may be required for relief.4
Suffocation-based treatments with occlusive agents may only partially impede lice ventilation. Examples of occlusive
agents are petroleum jelly (Vaseline), Cetaphil cleanser, and mayonnaise. Instead of lungs, lice have air channels throughout
their body such as in the prothorax and abdomen areas, allowing the diffusion of oxygen. These air channels can be closed
by structures called spiracles and any occlusive agent would need to block 100% of the spiracles for asphyxiation to occur.
The musculature of these spiracles responds much like a human cough to clear the airways and therefore smothering lice
is difficult.44,45
Pubic Lice
The pediculicides used to treat head lice are effective for pubic lice (see Table 5). The recommended regimens are permethrin
1% cream rinse or pyrethrins with piperonyl butoxide applied to affected areas then washed off after 10 minutes, with
retreatment in 7–9 days.8
If eyelashes are infested, nits and lice can be removed with tweezers, followed by an application of white petrolatum twice daily
for 10 days to asphyxiate the remaining lice. More data are needed to determine the efficacy of occlusive agents such as
petroleum jelly, olive oil or mayonnaise.46
Sexual contacts within the previous month should be treated if infested. Again, itching caused by the pediculicide can be
treated with an oral antihistamine or topical corticosteroid.4
Body Lice
Pediculicides are unnecessary. Simple hygienic measures, including bathing and laundering of infested clothing and linens in
hot water, are effective management. Alternative strategies for items that cannot be washed include dry cleaning or storing the
items in a sealed plastic bag for 2 weeks.5
If lice are adherent to body hairs, pediculicides may be helpful.4,5

Several natural health products are used as alternative pediculicides (e.g., anacyclus pyrethrum, anamirta, chrysanthemum
flowers, delphinium, field scabious, henna, tea tree oil, black pepper, ranunculus). There is insufficient clinical evidence of
efficacy for any of these herbs.14,47
Lavender oil and tea tree oil are often used in toiletries and in products to treat head lice. They have been associated with
cases of prepubertal gynecomastia in boys with normal endogenous steroid levels.48
After treatment of head and pubic lice, the dead nits will still be attached to the hair. They can be removed with fingertips, tweezers
or a fine-toothed (nit) comb. Observe for any recurrence of lice and nits. Further assessment and/or treatment is required for
patients with recurrent or unresponsive head lice or pubic lice following 2 treatments with recommended therapy.
For body lice infestations, inspect clothing and other personal items for the presence of lice.
A secondary bacterial skin infection with redness and pus may develop and may require topical antibacterial treatment. A
monitoring plan for patients with pediculosis can be found in Table 2.
4,9
Table 2: Monitoring of Therapy for Lice
Detection of live Patient: Daily for 2 wk Absence of live lice 24 h Treat again with pediculicide 7–10 days
lice after applying after initial application to eradicate any
pediculicide recently hatched immature nymphs.
Presence of adult lice may indicate
resistance and need for change of therapy.
Presence of nits Patient: Daily for 2 wk Absence of nits Vinegar, nit comb to physically remove dead
nits.
Pruritus Patient: Daily for 2 wk Relief of pruritus Oral antihistamines, topical corticosteroids.
Inflammatory Patient: Daily for 2 wk Clearing of any lesions If mild, topical antibiotics (e.g.,
pustules and return to normal bacitracin/polymyxin B). If unresponsive or
appearance of the skin extensive, systemic antibiotics may be
within 1 wk of treatment necessary.
.....
Scabies
Pathophysiology
Pathophysiology
Scabies is a highly contagious infestation of the skin with the human mite, Sarcoptes scabiei var hominis. It can occur across all
socioeconomic levels, but women and children have a higher number of infestations than men. Cycles of epidemics every 7–15
years occur in crowded living conditions and in institutions.49,50
Scabies infestations are most commonly transmitted through close personal contact, particularly sexual contact. Spread by
fomites such as furniture and towels is rare unless they were in contact with patients who had a very high parasite load.51 The
impregnated female mite, which has a rounded body and 4 pairs of legs, burrows (creates a tunnel) into the uppermost layer
(stratum corneum) of the epidermis, depositing feces along its path, and lays 2 or 3 eggs daily. She remains in the burrow and
continues to lay eggs for her lifespan of 4–6 weeks.52 Three or 4 days later, the eggs hatch into larvae with 6 legs that travel from
the burrow to the skin surface where they mature into adult mites within 14–17 days. On warm skin, mites are capable of crawling
2.5 cm per minute. The smaller male mite lives predominantly on the skin surface and dies shortly after mating with the female
mite. Patients typically harbour an average of 10–12 mites.4,5,53
Scabies can survive off the human host for an average of 2–36 hours at room temperature (21°C and relative humidity of 40–
80%). In a cool, humid environment, survival is increased to about 19 days.54
With a first infection, intense pruritus that is worse at night occurs after 3–4 weeks as a result of sensitization to the mites, eggs or
feces. After a reinfestation, pruritus may occur within 24–48 hours. Burrows (white or grey wavy lines) may be apparent, and an
immune response to the scabies mite results in erythematous papules or vesicles. The face and scalp are spared in adults but not
in infants and young children. Scratching leads to excoriations that may become secondarily infected with Staphylococcus aureus
or Streptococci pyogenes leading to pustules, furunculosis and impetigo. In areas of high prevalence, scabies is a risk factor for
developing acute poststreptococcal glomerulonephritis.50,51,52 See photo, Scabies.
Photo 1: Scabies
Dr. P, Marazzi/Science Photo Library
Immunocompromised hosts such as patients with HIV infection or lymphoma or institutionalized elderly persons may develop an
atypical, hyperkeratotic and more contagious form of scabies called crusted scabies (also referred to as Norwegian scabies).
Patients present with pronounced thickened skin patches especially affecting the scalp, hands and feet but may be generalized.
The lesions may be malodorous, and pruritus is minimal. Infested persons have huge numbers of mites (e.g., hundreds of
thousands) and this infection carries a high mortality rate due to secondary infection and sepsis.50,52
Goals of Therapy
Exterminate the scabies mite
Relieve the pruritus
Prevent the spread of the infestation
Patient Assessment
Intense pruritus that worsens at night is the most common presenting symptom. Affected patients exhibit silvery lines known as
burrows on the hands (especially the web spaces), flexor surfaces of the wrists and genitalia, but occasionally other sites such as
the axillae, buttocks and nipples may be involved. Papules may be present on the trunk. Children may have atypical lesions but
they are often concentrated on hands, feet, scalp and body folds.7 Table 3 provides characteristics and differential diagnosis of
scabies.
55,56
Table 3: Characteristics and Differential Diagnosis of Scabies
Condition Lesions Distribution Differential Diagnosis
Scabies Primary lesions are linear or Fingerwebs, wrists, sides Flea or insect bites: Lesions are usually
wavy burrows (2–5 mm long) of hands and feet, single or multiple papules.
with papules and vesicles near axillae, groin, breasts, Atopic dermatitis: Distribution is
burrows. belt line. behind knees or in fold of elbows.
Secondary lesions as a result of Seborrheic dermatitis: Scales in a
excessive scratching are distribution involving the scalp and
excoriations or eczema. face.
Secondary infections with Impetigo: Exhibits honey-coloured
impetigo or pustules are exudates and crusting; this may appear
possible. as a secondary infection.
Suspect scabies in all patients with a pruritic rash, especially if it worsens at night. Papules appearing on the genitalia and breasts
when other household members have similar signs and symptoms strengthen the diagnosis. However, a definitive diagnosis
should be made by an appropriate healthcare practitioner prior to treatment.52
Definitive diagnosis is made by mounting scrapings from nonexcoriated burrows, papules or vesicles in potassium hydroxide onto
a slide and examining under direct microscopy. Any sign of a mite, eggs or fecal material is a positive test.57,58
Clothes and linens should be washed in soap and hot water (60°C) and machine dried using the hot cycle, dry cleaned, or stored in
plastic bags for 5–7 days. All surfaces, rugs, furniture and unwashable items should be vacuumed. Avoid body contact with others
until completion of treatment and follow up. Children may return to school the day after treatment is completed.59 Fingernails
should be closely trimmed to prevent skin injury resulting from excessive scratching.60
There is insufficient evidence to determine the effectiveness of the traditional recommendation to treat close contacts of patients
with scabies prophylactically.61 However, the Public Health Agency of Canada recommends preventive treatment of sexual
partners within the last month62 and the Canadian Pediatric Society recommends treatment of all household contacts whether
symptomatic or not.63 The US Centers for Disease Control recommends that close contacts within the month preceding the
infestation should be examined and treated if infested.60
Products: Scabicides.
Topical Therapy
Permethrin 5% is an insecticide that appears to be more effective than all other scabicides,64,65,66 and it is the preferred
treatment for adults and children >2 months of age.60,62 Comparative trials of other scabicides including crotamiton and sulfur
have produced equivocal results suggesting there is no most effective second-line agent.64,67 Topical permethrin may be more
effective at reducing persistent itch than crotamiton.65 There are limited human studies of permethrin in pregnancy;68 however,
less than 2% of the topical dose of permethrin is absorbed and it is considered the drug of choice for treating scabies in
pregnant and breastfeeding women.62,69
Topical sulfur has many mechanisms of action including keratolytic, fungicidal, parasiticidal and antibacterial activity. Its
germicidal activity may be the result of conversion to pentathionic acid by epidermal cells or by certain microorganisms. In
organisms without lungs, such as insects or plants, sulfur prevents respiration. There is limited evidence of efficacy64,70 but it
is often recommended in a petrolatum base as the preferred therapy in infants <2 months of age due to low risk of toxicity.62,63
Odour and mess associated with application reduce adherence and limit use. Sulfur is considered a second-line agent.
Crotamiton 10% cream is an antiparasitic agent with an unknown mechanism of action. It reduces itch via a counterirritant
effect (creates a cooling sensation as it evaporates from the skin). Crotamiton is less effective than permethrin71 and
resistance has been reported.65,72 It is considered a second-line agent.
Lindane is an effective scabicide; however, there are concerns about possible neurotoxicity, bone marrow suppression and
carcinogenicity following percutaneous absorption.4,32,33 Lindane is no longer available in Canada.
Information on topical therapies for the treatment of scabies can be found in Table 6.
Systemic Therapy
Severe or resistant forms of scabies such as crusted (Norwegian) forms, infections in persons with HIV or outbreaks in
institutions are more difficult to treat and the failure rate is significant with the usual treatments. Oral ivermectin is often
recommended in these situations. Ivermectin is a broad-spectrum antiparasitic agent commonly used worldwide for various
parasitic infections. No serious drug-related adverse events have been reported. Adverse effects include fever, headache, chills,
arthralgia, rash, eosinophilia and anorexia. Many of these symptoms are thought to result from the death of parasites rather
than adverse effects from the drug. Low levels of ivermectin are detected in the CNS as it concentrates in the liver and fat
tissue. No significant drug interactions have been reported. It is not recommended for children <15 kg or in pregnancy and
breastfeeding since safety is unknown.76 Oral ivermectin is available in Canada only through Health Canada's Special Access
Programme.
Resistant or severe scabies can be treated with oral ivermectin 200 µg/kg orally, repeated in 2 weeks.60 In the treatment of
crusted (Norweigan) scabies, oral ivermectin 200 µg/kg as a single dose has limited evidence of efficacy but is considered
likely to be beneficial.65 To prevent resistance and improve efficacy, a combination of ivermectin 200 µg/kg on days 1, 2, 8, 9
and 15 (and days 22 and 29 in severe, unresponsive cases) along with topical permethrin 5% cream daily for 7 days then twice
weekly until cure is achieved, is often recommended.60 A concern about increased deaths in elderly people receiving this
combination77 has not been confirmed with further study.
Institutional epidemics of scabies occur frequently in hospitals, nursing homes, residential facilities, and other isolated
communities. Control of an epidemic can best be achieved by treating the entire population at risk. Ivermectin 200 ug/kg
(repeated in 7–14 days) can be considered in these settings, especially if treatment with topical scabicides fails or is too
difficult to coordinate. Epidemics should be managed in consultation with a specialist.60,78,79,80
The appearance of new burrows at any stage after treatment is an indication for further treatment. Itch resulting from an immune
allergic response to the mite can persist for up to 4 weeks and may be relieved with topical corticosteroids and/or oral
antihistamines or crotamiton.81,82 Mites separated from the host die in 72 hours. Table 4 presents a monitoring plan for patients
with scabies.
83,84
Table 4: Monitoring of Therapy for Scabies
Burrows Patient: Daily for the Clearing of burrows over the If new burrows are detected, then
following 2 wk following 2 wk and return to normal retreatment with a scabicide is
Healthcare practitioner: skin appearance. necessary. Ensure
Next visit nonpharmacologic measures are
utilized.
Papules Patient: Daily for the Clearing of papules and return to If new papules are detected, then
following 2 wk normal skin appearance. retreatment with a scabicide is
Healthcare practitioner: necessary after 7–10 days. Ensure
Next visit nonpharmacologic measures are
utilized.
Pruritus Patient: Daily for several Itching should resolve within If itching persists for several
wk several (up to 4) wk. Itching beyond weeks, then antihistamines, topical
Healthcare practitioner: 4 wk requires reinvestigation of the corticosteroids or crotamiton may
Next visit cause.82 be tried as antipruritic agents.72,85
Pustules, Patient: Daily for several This secondary infection should If no improvement or worsening
impetigo wk improve with 3 days of topical within 3 days of treatment, patient
Healthcare practitioner: antibacterial (bacitracin/polymyxin requires further assessment and/or
Next visit B) treatment. treatment.
.....
Drug Tables
Table 5: Topical Therapy for the Treatment of Head Lice11,20,21,22,23,24,25,26,27,28
Class Drug Mechanism of Administration Adverse Comments Costa
Action Instructions Effects
Pediculicides dimeticone 50% Noninsecticidal, Spray carefully Mild itching, Not $$$
NYDA physically all over dry ocular recommended
acting agent; hair. Massage irritation for infants or
penetrates in until hair is children younger
spiracles completely than 2 y.
causing wetted with Resistance to
suffocation or solution. Avoid product is
inhibition of contact with unlikely due to
water excretion eyes. Leave physical mode of
resulting in gut solution on action.
rupture from hair. After 30 No data on
osmotic stress. min, comb the safety during
Cure rate: 97% hair with a lice pregnancy and
Ovicidal comb. Allow breastfeeding.
activity: 100% the solution to Mixture is
but second dry on the hair volatile; keep
application still for at least 8 h away from open
recommended and then flame, sources of
due to wash. Repeat ignition, lit
imperfect after 8–10 cigarettes.
application.6 days.
Pediculicides isopropyl Noninsecticidal, Apply to dry Local Not $$

myristate/cyclomethicone physically hair and scalp irritation recommended
Resultz acting agent; (30–60 mL for with mild for infants or
dissolves the short hair, 60– erythema children younger
louse 90 mL for and scalp than 2 y.
exoskeleton, shoulder- pruritus Resistance to
leading to death length hair, If contact product is
from 90–120 mL for with eyes, unlikely due to
dehydration. long hair). immediately physical mode of
Cure rate: Allow product flush well action.
57–93%29,30 to remain on with water. No data on
hair and scalp safety during
for 10 min. pregnancy and
Rinse off with breastfeeding.
warm water.
Repeat in 7
days.
Pediculicides permethrin 1% Synthetic Wash hair with Mild, Drug of choice $

Kwellada-P Creme Rinse, pyrethroid; conditioner- transient for most
Nix Creme Rinse disrupts free shampoo, itching, patients.
sodium rinse with redness and Contraindicated
channels, to water and swelling. in patients with
delay towel dry. Uncommon chrysanthemum
repolarization Apply adverse allergy.
causing permethrin to effects Permethrin
respiratory saturate the include resistance may
paralysis of hair and scalp burning, result in
louse. (one-half to 1 stinging, treatment failure.
Cure rate: 96– bottle for rash, Compatible with
100% adults and tingling and pregnancy and
Ovicidal children with numbness. breastfeeding.
activity: 70– long hair);
80% leave on for 10
min then rinse.
May repeat
after 7 days if
live lice are
observed.
Pediculicides pyrethrins/piperonyl Naturally Apply to Contact Contraindicated $
butoxide occurring thoroughly dermatitis in patients
R&C Shampoo pyrethroid: saturate dry due to the allergic to
disrupts hair and petroleum ragweed,
sodium massage distillates chrysanthemums
channels, to scalp/skin; used for or other pyrethrin
delay leave on for 10 solvent products.
repolarization min. Add a purposes in Compatible with
causing little water; the pregnancy and
respiratory work the formulation. breastfeeding.
paralysis of shampoo into
louse. the hair and
Piperonyl skin to form a
butoxide is lather. Rinse
added to inhibit thoroughly.
pyrethrin Repeat
breakdown. treatment in 7
Cure rate: 45% days.
after 1
application;
94% after 2
applications.
Legend: $ <$10 $$ $10–20 $$$ $20–30

Table 6: Topical Therapy for the Treatment of Scabies
Class Drug Administration Instructions Adverse Comments Costa
Effects
Scabicides crotamiton Massage into all skin areas, from Local Less effective than $$
10% the neck down to the soles of the irritation. permethrin.71
Eurax feet; every bit of skin must be Considered second-
cream treated, including the fingernails, line treatment.
waist and genitalia. In infants and Resistance has been
young children, the entire head
reported.65,72
and neck should also be treated;
Multiple applications
repeat in 24 h. Do not wash off
until 48 h after last application. recommended.73
Not recommended
for patients with
exudative or
vesicular dermatitis.
Low toxicity and
beneficial antipruritic
effect.
Possible second-line
treatment during
pregnancy and
breastfeeding.69
Class Drug Administration Instructions Adverse Comments Costa
Effects
Scabicides permethrin Massage into all skin areas, from Pruritus, Drug of choice for Cream: $$
5%b the neck down to the soles of the edema and scabies in adults and Lotion: $$$
Kwellada- feet; every bit of skin must be erythema. children >2
P Lotion, treated, including the fingernails, months.57,64,66,65
Nix waist and genitalia. In infants and Resistance of
Dermal young children, the entire head scabies to
Cream and neck should also be treated. permethrin is
Leave on for 8–14 h without
rare.73,74
interruption, then wash off
Contraindicated in
(shower may be the best way).
patients allergic to
chrysanthemums.
Second
administration 1 wk
after first often
recommended.3
Recommended
during pregnancy
and
breastfeeding.60,68,75
Scabicides sulfur 5– Apply to all skin areasd QHS for Local Limited study data to $
10%c 5–7 days. irritation or support use.64,70
dermatitis Considered a
Infants <2 months: 8–10% in with
petrolatum. Apply to all skin second-line
repeated treatment.
areasd QHS for 3 days.63 applications. Not popular because
it is malodorous,
requires multiple
applications and
stains clothing.
Extemporaneously
compounded.
Possible second-line
treatment during
pregnancy and
breastfeeding.69

b Lower strengths are not effective as scabicides.
c Extermoraneously compounded preparations can be used.
d As for permethrin.
Legend: $ <$10 $$ $10–20 $$$ $20–30
Suggested Readings
Chosidow O. Clinical practices. Scabies. N Engl J Med 2006;354:1718-27.
Gunning K, Pipitt K, Kiraly B et al. Pediculosis and scabies: treatment update. Am Fam Physician 2012;86:535-41.
Head lice infestations: a clinical update. Paediatr Child Health 2008;13:692-6. [Reaffirmed February 1, 2014].
Ko CJ, Elston DM. Pediculosis. J Am Acad Dermatol 2004;50:1-12.
References
1. Harris J, Crawshaw JG, Millership S. Incidence and prevalence of head lice in a district health authority area. Commun Dis
Public Health 2003;6:246-9.
2. Burkhart CN, Burkhart CG. Scabies, other mites, and pediculosis. In: Goldsmith LA, Katz SI, Gilchrest BA et al. Fitzpatrick's
dermatology in general medicine. 8th ed. New York: McGraw-Hill; 2012.
3. Chosidow O. Scabies and pediculosis. Lancet 2000;355:819-27.
4. Goldstein BG, Goldstein AO. Pediculosis. Available from: www.uptodate.com/login. Subscription required.
5. Ko CJ, Elston DM. Pediculosis. J Am Acad Dermatol 2004;50:1-12.
Perspiration and Body Odour

Pathophysiology
Sweating is essential for regulating body temperature. Sweat production increases in response to an increase in body temperature
and produces a cooling of the body.1 Normal body temperature is regulated through receptors in the hypothalamus that monitor the
core temperature, and skin receptors that monitor the external temperature. Sweat glands consist of a secretory coil in the dermis
and a duct that transports sweat to the skin surface (Figure 1). Failure of this regulating system to reduce body heat can lead to
heat exhaustion, heat stroke, hyperthermia and in extreme cases death.2 Excessive local or systemic sweating is called
hyperhidrosis and can be socially and psychologically disabling.3
There are 3 main types of sweat glands: eccrine, apocrine and apoeccrine.2
Eccrine sweat glands are primarily responsible for body cooling. They cover the skin surface, with the greatest numbers on the
palms, soles, face, head and trunk. Eccrine sweat is primarily hypotonic (sodium, chloride and bicarbonate are reabsorbed
through the eccrine duct) which conserves electrolytes during excessive sweating.2
Apocrine glands are larger than eccrine glands, open into hair follicles and are primarily found in the underarm, nipple and
genital areas.2 Apocrine glands become functional at the time of puberty. Apocrine sweat is a milky, viscid, odourless secretion
containing fatty substances, but develops an odour once it reaches the skin's surface.
Apoeccrine glands have structural features of both eccrine and apocrine glands. Like the eccrine gland, they have a long duct
and open directly onto the skin's surface. They are found only in the underarm area of adults and also develop at puberty.
Apoeccrine glands secrete nearly 10 times as much sweat as eccrine glands.2
Figure 1: The Skin
Physiologic sweating is a natural reaction to thermal and emotional stimuli. Hot environments, over-clothing and exercise all trigger
the hypothalamic sweat centre to increase heat loss through cutaneous vasodilation and generalized sweat production, especially
on the face and trunk. Sweating around the lips and forehead is a physiologic response to eating hot or spicy foods. Emotional
stimuli such as anxiety, embarrassment, fear, anger, excitement or mental stress can cause sweating from the palms, soles,
underarms and forehead.4 Hyperhidrosis is classified as primary or secondary as described below.3
Primary hyperhidrosis is excessive sweating beyond that required for body cooling and is believed to be due to a dysfunction in
the autonomic nervous system. It is estimated to affect about 1–3% of the general population and can occur at any age. The
axillae are the most commonly affected area (73%) followed by the hands (46%), feet (41%), scalp (23%) and groin (9%).5
Children generally present with palmoplantar hyperhidrosis whereas axillary hyperhidrosis is more common after onset of
puberty. Hyperhidrosis is uncommon in the elderly.6,7,8 Primary hyperhidrosis is not usually associated with odour but sweating
can be excessive to the point of affecting a person's quality of life (e.g., cold sweat is dripping off the hands or face and
damaging papers or books; clothing can become wet leading to an increased risk of infection due to the constant dampness in
a concentrated area of the skin).3
Secondary hyperhidrosis is more generalized and occurs over the entire body. It is typically associated with menopausal
changes and diseases such as diabetes, hyperthyroidism and obesity but can also occur in respiratory failure, chronic
infectious diseases, some psychiatric disorders, malignancy, fever, and alcohol or drug withdrawal.1,3,9 Hyperhidrosis may also
be secondary to the use of medications such as ASA, insulin, morphine, fluoxetine and acetaminophen.3,7,9
Bromhidrosis is a chronic condition involving sweat that has an offensive odour. Sweat from the eccrine glands is usually odourless,
although occasionally excretion in sweat of odour-causing chemicals like garlic, onions and fish can produce an odour. Body odour
is generally produced by the action of bacterial decomposition of fatty substances in apocrine sweat. The odour produced from feet
is often associated with footwear that does not allow air to circulate, causing excessive sweating and growth of bacteria.3
Predisposing factors for bromhidrosis include hyperhidrosis, obesity and poor body hygiene.1
Goals of Therapy
Control socially undesirable body odour
Control underarm wetness resulting from normal, physiologic sweating
Reduce the quantity of sweat excretion in hyperhidrosis to a tolerable level that permits participation in work and social
situations
Prevent complications of hyperhidrosis involving the feet—odour, blisters and skin infection
Patient Assessment
Concerns about body odour and underarm wetness resulting from normal, physiologic sweating can often be managed with self-
treatment. Patients with excessive sweating that has not been controlled with regular use of antiperspirants or deodorants,
increased sweating of recent onset in adults, or sweating that occurs in an unusual pattern with no explanation should be assessed
in order to eliminate neurologic (spinal injuries, Parkinson's), cardiovascular (heart failure), endocrine or metabolic disorders
(hyperthyroidism, diabetes, menopause) and to identify potential drug causes3 (see Pathophysiology).
Criteria for diagnosing primary hyperhidrosis can include:7,10

Onset of symptoms <25 years of age increases suspicion but it can occur at any age
At least 6 months' duration
Sweating occurs in the absence of normal thermal or emotional stimuli and more than once per week
Occurs in one or more sites (axillary, palmoplantar, scalp, groin) and affects daily life
Positive family history (genetic connection)
Sweat production can be assessed with a simple starch-iodine test that identifies areas of concern. An iodine solution is applied to
the area of skin to be evaluated, and left to dry. A starch (potato or corn) is sprinkled over the area being tested. Sweat will produce
a dark blue discoloration. This process can be repeated after several weeks to identify areas of improvement and areas that need
further treatment.11
An assessment plan for patients with perspiration-related complaints is presented in Figure 2.
General Measures
Wear clothing that is cool and porous and made from natural fibres that are more breathable than synthetics, particularly in the
underarm area. Underarm shields primarily act as barriers and absorb sweat, preventing wetness from staining clothing. Wash
clothing in hot water to remove body odour before wearing again. If possible, avoid spicy foods, alcohol, exercising in hot weather
and stressful situations that can trigger strong emotions.3,4,6 Water and electrolytes lost through excessive sweating should be
replaced regularly.
Personal Hygiene
To manage body odour, a regular bath or shower using soap and water will help to prevent buildup of bacteria, sweat and dead skin
cells that interact to produce body odour. A daily bath or shower may be necessary for some people. When a full bath or shower is
not possible, sponging in the underarm and genital areas can help control the major source of body odour. Shaving the armpits can
reduce the propagation of body odour by reducing the surface area for bacterial action.3 If underarm skin is irritated, avoid soap
products that cause further irritation and use unscented cleansers instead.
Foot Care
Foot care is important for patients with excessive foot sweating (plantar hyperhidrosis) and/or odour. Feet should be washed
regularly using a skin cleanser and dried thoroughly. Daily washing may be needed for odour control followed by application of an
absorbent foot powder twice a day. Non-occlusive footwear made of natural materials, such as leather shoes or sandals, should be
worn with cotton or wool socks. Alternating with different pairs of shoes each day will allow them to dry thoroughly. Socks should be
changed twice daily to ensure the feet remain dry and are not at risk of fungal infections (athlete's foot).3 See Athlete's Foot.
Iontophoresis
Iontophoresis uses a water bath apparatus to introduce a mild electrical current of soluble ions into the skin: it is thought to work by
blocking the sweat ducts at the skin surface or by inducing an electrical change in the sweat glands and disrupting secretion.3
Iontophoresis is often used for hyperhidrosis of the hands and feet not responding to conservative therapy.3,7 Evidence to confirm
efficacy is limited12,13,14 but it is widely recommended. Commercially available devices can be used at home. The process is time
consuming and not practical for some, depending on the area being treated.1 Up to 4 treatments per week may be needed initially,
each lasting 30 minutes.7 Side effects are minor and consist of dry or cracked skin, tingling or burning and rarely redness and small
blisters. If any of these side effects occur, the voltage can be decreased. An emollient can be applied for dry skin or a low-potency
topical corticosteroid can be used to treat inflammation/redness.3 Iontophoresis in contraindicated in anyone who is pregnant, has
an orthopedic prosthesis or has a pacemaker.11
Surgery
Surgery is considered only when all other options for treatment have failed (see Pharmacologic Therapy) and permanent elimination
of sweating is desired. There are 2 types of surgical options. One approach involves removal of the axillary sweat glands by
excision, liposuction, curretage or laser. Removal of axillary glands is generally performed in a dermatologist's office under local
anesthesia15 and is considered an emerging therapy as the evidence base is limited.6 A second method, endoscopic thoracic
sympathectomy (ETS), is a major surgical procedure involving cutting nerves that signal sweat glands. It is mainly used to treat
palmoplantar hyperhidrosis. In addition to the risk of surgical complications with ETS, a major disadvantage is that compensatory
hyperhidrosis may be induced in other areas of the body (usually back, abdomen, thighs, chest) which can be worse than the original
condition.3,6,11,16
Other Nonpharmacologic Options
Microwave energy is readily absorbed by tissues with a high water content and is used in a new treatment being used for primary
hyperhidrosis. The miraDry device is used in some clinics in Canada but requires further studies to confirm efficacy and long-term
safety. The procedure takes about 1 hour to complete and must be repeated after 3 months.15
Treatment with various laser techniques may be beneficial for some patients with axillary hyperhidrosis. Evidence is limited to small
studies.17
Topical Therapy
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Antiperspirant
and Deodorant Products.
First-line treatments used to manage perspiration and body odour problems in most cases are antiperspirants and deodorants as
described in Table 2. The mainstay of treatment is daily use of antiperspirants as part of a personal hygiene regimen.
Antiperspirants reduce sweating by mechanically obstructing the eccrine gland pores, causing the sweat to thicken and clump.
Once plugged, the sweat gland ducts receive a signal to reduce or stop perspiration, and this effect can last for 24 hours or
longer.1,3 The effect wears off during the usual epidermal renewal process, however there is some evidence that long-term use of
aluminum salts causes destruction of some secretory cells which may account for the clinical observation that decreased
frequency of application is required over time.18 Antiperspirants work best for axillary sweating but can also be applied to any
problematic body area (hands, feet, face, back, chest, groin). Irritation may be more common in more sensitive areas.10 Skin
irritation is the most common side effect and may be caused by the active ingredient, or by perfumes or preservatives used as
additives.
Most standard commercial antiperspirant products contain partially neutralized aluminum salts (e.g., complexes with zirconium)
which create superficial duct blockage that lasts for 24 hours or longer but does not cause irritation with once or twice daily use for
most patients. If standard products are not effective, “clinical strength” products containing aluminum chloride (or aluminum
chloride hexahydrate) may be tried. These products are more effective as they create deeper and more effective duct blockages but
they are also more irritating as aluminum chloride reacts with water or sweat to form hydrochloric acid, thereby requiring precise
adherence to application instructions.
Tips for effective use of antiperspirants:10,19

All antiperspirants are more effective if applied at bedtime when sweat glands are less active. More active ingredient can enter
the sweat duct and create better plugs.
Showering the morning after nighttime application of antiperspirants will not reduce their effectiveness as the plug has already
formed in the sweat gland below the level of the skin.
Unlike standard antiperspirants, it is recommended that aluminum chloride products be washed off the morning after
application so that any product remaining on the surface of the skin is removed. This reduces the risk of irritation due to the
production of hydrochloric acid from the reaction between aluminum chloride and any sweat that may be produced during the
day. Topical hydrocortisone 1% cream may be used to treat irritation if it occurs despite careful application.
Irritation can be minimized or avoided by making sure the skin is completely dry (using a cool blow dryer if need be) before
application. This is especially important before application of aluminum chloride products, as hydrochloric acid is produced
when aluminum chloride mixes with water/sweat.
There is no evidence that occluding the skin (e.g., with plastic wrap) while using antiperspirants increases efficacy but it may
increase irritation.
Continuous use of antiperspirants may allow for less frequent application over time. Some patients using aluminum chloride
products find initial application every 24-48 hours may be gradually reduced to once every 1-3 weeks while still maintaining
effectiveness.
Waiting 24-48 hours after shaving before applying aluminum chloride products to the shaven skin will reduce the risk of
irritation. This is usually not necessary with standard strength products.
There is no evidence of any connection between use of aluminum-containing antiperspirants and Alzheimer's disease (or any other
dementias) or breast cancer.19,20,21
Deodorants do not prevent sweating but mask body odour with fragrance or by reducing the bacterial population in the area.
Aluminum- or zinc-containing deodorants have antibacterial action. Alum has been used traditionally as a water purifier; “natural” or
“crystal” deodorants usually contain potassium alum or ammonium alum crystals. Other products that have been used as
deodorants are vinegar, sodium bicarbonate and isopropyl alcohol.3
Products used to control foot odour contain combinations of zinc oxide, sodium bicarbonate, corn starch, aluminum and alcohol.
Astringents like formaldehyde, glutaraldehyde, methenamine and tannic acid were once used to treat hyperhidrosis by plugging the
pores. These chemicals are no longer used because of contact sensitivity or skin discoloration.3
Other Therapy
OnabotulinumtoxinA injection blocks the release of acetylcholine from cholinergic fibres and is beneficial in the treatment of
hyperhidrosis. It is approved for treatment of primary hyperhidrosis of the axillae where it reduces sweat production by 75–100%.6
Although not approved for use on other sites it has been also used clinically for hands, feet, face and groin.22,23 It is used as first-
line treatment for moderate to severe primary hyperhidrosis of the axillae or for milder cases when topical treatment has failed after
1 month of continuous treatment.24 Sweat reduction should be noticed after 2–4 days and should be significant after 2 weeks.24
The procedure consists of a number of injections (average of 10–15 per axilla) and the effects last from 4–12 months, after which
treatment is repeated. It is painful (topical anesthetics are therefore used) and expensive. Research into administration via
microneedles, resulting in less pain, is ongoing.3,7 Use of onabotulinumtoxinA is not recommended during pregnancy and
breastfeeding and in patients with neuromuscular disorders.
Anticholinergics may be helpful in certain cases. Glycopyrrolate is safe and effective when used topically, particularly for
craniofacial hyperhidrosis for which there is the most evidence.25,26,27 It has also been used orally.28 Hyperhidrosis is not a Health
Canada–approved indication.
Oxybutynin has been used orally in patients with multifocal primary hyperhidrosis, compensatory hyperhidrosis (e.g., following ETS
surgery), or in those for whom topical treatments, iontophoresis and onabotulinumtoxinA (or combinations of these) have not been
satisfactory.3,24,28,29 Use for hyperhidrosis is not a Health Canada–approved indication. Oral anticholinergics are not recommended
in patients with glaucoma, impaired gastric emptying or urinary retention and may interfere with thermoregulation in situations
where patients are at risk of becoming overheated as it may limit their ability to sweat for cooling purposes.
Table 1 provides a monitoring plan framework which should be individualized.
Table 1: Monitoring of Therapy for Perspiration and Body Odour

Underarm wetness Monitor daily for 2–3 wk while Dry axillae in resting, non- If aluminum chloride products are
using antiperspirants (try stressed state at effective, reduce frequency to
standard followed by comfortable room level required to maintain effect.
aluminum chloride products if temperature after 2–3 wk If patient cannot tolerate
needed) as well as a daily of intervention. aluminum chloride products (mild
personal hygiene routine. or stronger strengths) or is not
responding after a 2- to 3-wk
treatment trial, other treatment
options should be considered.
Hand sweating Monitor daily while using Hand sweating reduced to If hand sweating interferes with
antiperspirants (try standard a tolerable level after 4 wk social or occupational activities,
followed by aluminum chloride of intervention. refer to a physician.
if needed) applied to the palms If patient cannot tolerate
of the hands for 1–3 wk. aluminum chloride or is not
responding after a 3-wk trial, other
treatment options should be
considered.
Foot sweating Monitor daily while using a Foot sweating reduced to a If patient cannot tolerate products
regular foot care routine tolerable level after 3 wk of containing aluminum chloride or
including nonpharmacologic treatment. is not responding to treatment
therapy as indicated after a 3-wk trial, other treatment
previously. options should be considered.
Monitor daily for 1–3 wk while
using antiperspirants and/or
absorbent foot powders.
Body odour Monitor daily while using a Offensive body odour If personal hygiene measures and
personal hygiene routine that eliminated after 1–2 wk of antiperspirants are ineffective
includes washing with soap intervention. after 1–2 wk, other treatment
and water, changing clothing options should be considered.
as required and regular use of
antiperspirants.
Skin irritation from Ensure correct use (to Antiperspirant tolerated If irritation continues, stop
antiperspirants completely dry skin) and if with minimal or no antiperspirant and consider other
irritation continues, use a irritation. treatment options.
different brand or a lower Further therapy may be necessary
concentration aluminum for severely irritated skin.
product or a deodorant that is
aluminum-free.
Treat symptomatically with
low-potency topical
corticosteroid cream twice
daily for no more than 14 days
if irritation severe.
Side effects of Monitor daily for dry mouth, Side effects tolerable. Discontinue use in consultation
anticholinergic urinary hesitancy, mydriasis, with healthcare practitioner if side
drugs photophobia). effects affect quality of life.
Algorithms
Figure 2: Assessment of Patients with Perspiration and/or Body Odour Complaints

Drug Table
Table 2: Therapy for the Management of Perspiration and Body Odour6,10,28,30,31,32
Class Drug Dosage Adverse Drug Interactions Comments Costa
Effects
Anticholinergics glycopyrrolateb Capsules: 1– Oral: Oral: Caution with Often used for $
Avert Capsules, 8 mg daily in Mydriasis, dry concommitant use craniofacial
Secure Pads 1–3 divided mouth, of other hyperhidrosis.
doses po dizziness, anticholinergics Topical pads:
Pads: 0.5–4% constipation, (increased risk of Avoid contact
impregnated urinary adverse effects); with eyes, nose
pads wiped retention. may decrease and mouth.
onto cleaned, Topical: Mild serum levels of Not a Health
affected area headache haloperidol, Canada–
once daily, or levodopa; may approved
on a PRN increase indication.
basis before bioavailability of
excessive atenolol, metformin;
sweating effect of
triggers only glycopyrrolate may
be decreased by
acetylcholinesterase
inhibitors.
Topical: No
information
available.
Effects
Anticholinergics oxybutynin 2.5–20 mg Dry mouth Caution with Generally $

generics daily in 1–3 (most concommitant use reserved for use
divided doses common), of other in recalcitrant
po mydriasis, anticholinergics cases or in
constipation, (increased risk of multifocal
nausea, adverse effects); hyperhidrosis or
dizziness, oxybutynin effects compensatory
urinary increased by strong hyperhidrosis.
retention CYP3A4 inhibitors. Not a Health
Canada–
approved
indication.
Antiperspirants aluminum salts , Apply to Local Not applicable. Avoid $$

various (e.g., completely irritation. application on
aluminum dry skin on freshly shaved
zirconium affected area or abraded skin
tetrachlorohydrex daily to BID (if to reduce
glycine, aluminum once daily, HS irritation.
chlorohydrate) in preferred)
solid, spray formats
Arrid, Speed Stick,
others
Antiperspirants aluminum chloride, 6.25%–20%: Local Not applicable. A cool blow $$$
aluminum chloride Apply to irriation. dryer may be
hexahydrate completely Correct used to
Drysol, Perspirex, dry skin on application completely dry
others affected area and starting the skin prior to
at HS × 3 with weaker application.
days or until strengths can No evidence
desired effect minimize that occlusion
reached and irritation. of the area with
then taper to plastic wrap
2–3 times improves
weekly to efficacy, but
maintain may increase
effect. irritation.
Choose
weaker
strengths for
sensitive
areas such as
forehead, and
stronger
strengths for
palms and
soles
Effects
Botulinum onabotulinumtoxinA 50 U injected Localized Theoretically, drugs Pre-procedure $375/100

Toxins Botox intradermally pain, interfering with local anesthesia unit vial
at evenly inflammation, neuromuscular generally
distributed swelling, transmission may needed to
sites bleeding, potentiate the effect reduce pain
approximately bruising, of during
1–2 cm apart muscle onabotulinumtoxinA. administration.
in the weakness. Caution with
affected part Headache, aminoglycoside
of the axilla hot flush, antibiotics
(average 10– abnormal skin (amikacin,
15 injections odour, gentamicin,
per axilla); subcutaneous neomycin,
repeated nodules. streptomycin,
when effect tobramycin) and
wears off neuromuscular
(usually 4–6 blocking agents
months) (anticholinesterases,
lincosamides,
magnesium,
polymyxins,
quinidine,
succinylcholine,
tubocurarine).
Deodorants potassium Crystal Possible local Not applicable. Mask/neutralize $$

alum/ammonium format: irritation. body odour
alum Moisten only.
Crystal Body crystal then
Deodorant, others apply to
affected area
Deodorants zinc salts (water Apply to Possible local Not applicable. Tend to be $$
soluble: zinc affected area irritation. contained in
chloride, zinc daily foot powders
gluconate, zinc and sprays.
lactate), zinc oxide,
corn starch
Dr. Scholl's Powder,
Odor Eaters, others
a
Cost of 1-day supply or smallest available pack size unless otherwise specified; includes drug cost only.
b
Limited availability: does not require a prescription and can be ordered at www.pharmacy.ca.
Legend: $ <$3 $$ $3–6 $$$ $6–9
Suggested Readings
Nyamekye I. Current therapeutic options for treating primary hyperhidrosis. Eur J Vasc Endovasc Surg 2004;27:571-6.
Pariser DM, Ballard A. Topical therapies in hyperhidrosis care. Dermatol Clin 2014;32:485-90.
Perera E, Sinclair R. Hyperhydrosis and bromhidrosis. Aust Fam Physician 2013;42:266-9.
Schlereth T, Dieterich M, Birklein F. Hyperhidrosis–causes and treatment of enhanced sweating. Dtsch Arztebl Int 2009;106:32-7.
References
1. Nyamekye I. Current therapeutic options for treating primary hyperhidrosis. Eur J Vasc Endovasc Surg 2004;27:571-6.
2. Mauro T, Goldsmith L. Biology of eccrine, apocrine and apoeccrine sweat glands. In: McGraw-Hill AccessMedicine.
Dermatology. Subscription required. Accessed June 18, 2009.
3. Clark C. Sweating and hyperhidrosis. Pharmaceutical J 2006;276:757-60.
4. Leung AK, Chan PY, Choi MC. Hyperhidrosis. Int J Dermatol 1999;38:561-7.
5. Lear W, Kessler E, Solish N et al. An epidemiological study of hyperhidrosis. Dermatol Surg 2007;33:S69-75.
Psoriasis

Pathophysiology
Psoriasis is a chronic inflammatory, skin disorder characterized by palpable, erythematous plaques and papules, often
with a silver scale. It belongs to the group of papulosquamous cutaneous disorders, which are the most commonly
encountered skin problems.1 They may be difficult to distinguish from one another.
Psoriasis is a common medical condition in which psychosocial issues create a significant burden. In Canada it is
estimated that 1–3 % of the population has psoriasis. Although the onset is seen at any age from infancy to old age,
incidence peaks at 2 ages: 16–22 years for the more severe, type I psoriasis, and 57–60 years for the less severe, type II
psoriasis. Approximately 25% of affected patients have severe conditions. Men and women are affected equally. The
disorder occurs in all ethnic groups. Increased frequency in certain ethnic groups and geographical areas is likely
related to both genetic and environmental factors. It is more common in colder northern climates than tropical regions,
and Caucasians are more affected than other groups.2 Exogenous and endogenous factors such as upper respiratory
infection, psychological stress, humidity and cold weather are known to influence the clinical course of psoriasis
regionally. Diets high in protein, unsaturated fat, and essential fatty acids and low in carbohydrate, ascorbic acid and
tocopherols may account for reduced prevalence of psoriasis in groups such as Inuit. This has led to the suggestion
that fish oil may be appropriate supplementary therapy.3
Psoriasis is probably inherited via a multifactorial rather than a simple gene pattern. Genetic and environmental factors
determine the clinical manifestations. About 30% of patients with psoriasis have a positive family history. If both
parents are psoriasis sufferers, there is a 70% chance of contracting the disorder. Although family history is more
closely associated with earlier onset psoriasis, it will not predict the age of onset, severity of disease, or coexistence of
psoriatic arthritis.
Up to one-third of psoriasis patients may have coexisting psoriatic arthritis. Although the erythrocyte sedimentation rate
(ESR) is often elevated, the generalized subtype may be distinguishable from rheumatoid arthritis by the absence of
rheumatoid factors or other autoantibodies.
Psoriasis is a T-lymphocyte–mediated systemic inflammatory disease involving both acquired and innate immunity
from a complex interplay between multiple genetic factors and environmental influences. Epidermal hyperplasia,
vascular changes and the clinical signs of psoriasis all result from chronic T-cell-mediated inflammation within the
psoriatic plaque.4 An antigenic stimulus activates dermal dendritic cells, which secrete pro-inflammatory cytokines
including interferon alpha and interleukins (IL-23 and IL-12). This leads to activation of CD4 and helper T cells (TH-1, TH-
17), and formation of additional cytokines and growth factors. Lymphoid structures form in the dermis. Positive
therapeutic interventions can reverse the psoriatic phenotype without residual damage; however, in psoriatic arthritis,
the damage is significant and irreversible.
As a result of pathogenic T-cell production, psoriatic epidermal cells proliferate sevenfold faster than normal epidermal
cells. The dividing epidermal cell cycle is shortened from 163 hours to 37 hours, a higher proportion of basal layer
keratinocytes enter the active cell cycle, and psoriatic keratinocytes travel from the basal cell layer to the surface in 3–4
days, much more rapidly than the normal 26–28 days. Decreased keratinocyte transit time does not allow for normal
maturation and keratinization. This is reflected clinically by characteristic silvery scaling, a thickened epidermis with
increased mitotic activity and by the presence of immature nucleated keratin cells in the stratum corneum.4 Lesion-free
skin is actually considered to be affected, because epidermal proliferation is elevated in this apparently normal skin of
patients with psoriasis. Leukocyte chemotaxis may lead to local pustule formation and a generalized inflammatory
response results in erythroderma.5,6
Lifestyle factors associated with development of psoriasis include smoking and alcohol consumption.7 A high rate of
alcoholism is seen some studies of patients with psoriasis; alcohol and smoking contribute to worsening.8 Obesity and
other features of the metabolic syndrome (e.g., dyslipidemia, hypertension, glucose intolerance) are more prevalent in
patients with psoriasis.7 Stress and anxiety frequently precede flares. Psychosocial problems plague patients with
psoriasis, who have visible signs and symptoms that can have a profound effect on quality of life. Patients are self-
conscious in public places, refusing to participate in health clubs or sporting activities. Clothes have to be chosen
carefully so they will not allow shedding scale to be detected. Psoriasis may also inhibit intimate relationships and
sexual activity.
Psoriasis and psoriatic arthritis have been associated with human immunodeficiency virus (HIV) infection. Exacerbation
of psoriasis or difficult-to-control psoriasis in an at-risk individual warrants HIV status investigation.4
The course of psoriasis is prolonged and unpredictable. In most patients, the disease remains as discrete localized
plaques. However, extensive or even generalized involvement may develop, compromising quality of life. Spontaneous
clearing is rare. Unexplained exacerbation or improvement is common. Psoriasis resolves without scarring, but may
leave temporary hypopigmentation.9,10 It is a disease of control rather than cure, with relapses occurring unpredictably
after weeks or months of remission.
Goals of Therapy
Eliminate or reduce trigger factors
Reduce or eliminate signs of psoriasis such as scale and plaques
Relieve associated symptoms; alleviate pruritus and minimize excoriations
Reduce the frequency of flares or extend symptom-free intervals
Treat comorbid conditions (psoriatic arthritis, hypertension, dyslipidemia, diabetes, depression)
Minimize treatment-associated adverse effects
Maintain or improve quality of life
Patient Assessment
Psoriasis can present with wide-ranging severity affecting vastly different parts of the body. Limited areas may be
involved or diffuse generalized disease can be present. Most lesions are asymptomatic. Pruritus may occur in 20–
25% of patients. Patients with generalized psoriasis may have facial, trunk or flexural involvement, which may be
scattered, discrete, guttate or large plaques. Those with generalized disease may demonstrate all signs and
symptoms of exfoliative dermatitis, including loss of thermoregulation, warm skin, a feeling of chilliness, shivering,
increased protein catabolism and cardiovascular stress.4 Ten percent of patients with psoriasis may have either
migratory stomatitis or glossitis.
Diagnosis is usually based on the typical appearance and history of the lesions. A positive family history, detection
of lesions in characteristic sites undetected by the patient, or presence of nail changes and psoriatic arthritis may
also assist diagnostically.
Nails are affected in 50% of patients and careful total skin examination may reveal nail punctate pits or distal
destruction of a nail with loss of color and thickening, and subungual collections of keratotic material, showing
psoriatic involvement of the nail matrix or nail bed, respectively. A yellow-brown discolouration of the nail is
characteristic. Patients with distal interphalangeal joint involvement or arthritis mutilans usually have adjacent nail
involvement.5
Psoriatic arthritis occurs in up to one-third of patients. Patients commonly present with asymmetric oligoarthritis
(1–4 joints affected) but can also present with symmetric polyarthritis. Oligoarticular or polyarticular pain,
tenderness, and morning stiffness, especially in the small joints of the hands and feet, are early manifestations.
Intense pain may be present in large joints and in the cervical or lumbosacral spine.4
Comorbidities in the form of cardiovascular disease, metabolic syndrome and other inflammatory disorders are
common in psoriasis.
Types of Psoriasis
Psoriasis presents in various clinical forms based on morphology: plaque psoriasis is most common (90%). Other
forms of psoriasis include inverse, guttate, pustular and erythrodermic psoriasis, which are less common. Plaque
and inverse psoriasis are chronic conditions whereas guttate, pustular and erythrodermic psoriasis are acute or
subacute variants.
Chronic plaque psoriasis presents with the classic lesion: a well-demarcated, thickened, red plaque with a loosely
adherent immature silvery-white scale, which tends to become confluent. It occurs either as single lesions or as
generalized disease over a wider area. The character of the lesion may vary from minimal redness to thick, scaly red
plaques. Scaling can be made noticeable by scratching the surface of a lesion. If the covering scale is removed, a
salmon-pink to erythematous lesion is exposed, sometimes with punctate bleeding from prominent dermal
capillaries (Auspitz sign). Appearance of lesions varies with the location affected. In the classic form, plaques are
thick with silvery scale and acute lesions tend to be small and drop-shaped. They occur typically on the extensor
surface of the arms and legs, elbows, knees, sacrum, buttocks and scalp, but the ears, extremities, palms and soles
are also common sites. Scalp involvement may vary from diffuse scaling on an erythematous scalp to thickened
plaques with exudation, microabscesses and fissures. Lesions often extend onto the face, particularly along the
hairline. Hair loss over time is the most frequent manifestation of psoriasis and an important psychological
handicap. It may resemble seborrhea, and an inspection of the entire skin is important in a differential diagnosis.11
Inverse psoriasis represents 2–6% of psoriasis. The lesions occur in flexural areas (such as skin folds in the groin or
axillae). Moisture and friction in these areas contribute to thinner, shiny or glossy well-demarcated red plaques with
less scale and possible breakdown or cracking of the skin. Initial presentation may be localized to a single site.
Lesions may be moist and often fissured.12 The degree of impact on the patient does not correlate to total body
surface area involved. Differential diagnosis is important to rule out erythrasma or seborrhea.
Guttate psoriasis, named for its drop-like appearance, presents as a sudden eruption of pinpoint, dark red and
subsequently scaling lesions on the trunk and limbs, often preceded by a viral or streptococcal infection in children
or young adults. It may be induced by superantigen stimulation of T cells and occurs characteristically as an initial
presentation of psoriasis in genetically susceptible patients. Diagnosis may be confirmed by a throat swab and an
antistreptolysin O titer (ASOT) even in unrecognized or asymptomatic cases. Despite treatment of the initial
symptomatic streptococcal infection, guttate psoriasis may take many months to resolve, and recurrent upper
respiratory infections may induce flares.13,14
Pustular psoriasis may be generalized (acute) or localized (subacute). In the generalized form, patients with or
without a previous history develop systemic symptoms including fever, leukocytosis and general malaise. Average
age of onset is 50 years. Pregnancy, infection or recent use of systemic corticosteroids may be triggers. The sterile
pustules often start in localized plaques and may generalize quickly without systemic treatment. Individual lesions
are often painful erythematous plaques with rows or clusters of tender, bright yellow, nonfollicular pustules. This is
an acute emergency requiring systemic therapy and may be resistant to treatment.13 The localized pustular form of
psoriasis is often seen on the trunk and proximal extremities. It may respond to topical treatment but systemic
agents are often necessary. Chronic pustular psoriasis limited to the palms and soles is more common in women
who smoke. Deep painful pustules, clustered in erythematous plaques, extend from the palms and soles around the
sides of the hands and feet to the dorsal surface.5,15
Erythrodermic psoriasis presents as a nonspecific, fiery erythema over 75% of the body with desquamation and
edema. This unstable acute form may develop from chronic forms of psoriasis and may be associated with serious
systemic illness. Provoking factors include sudden withdrawal of potent therapies (especially systemic
corticosteroids), drug reactions, trauma or illness.
A wide variety of environmental triggers may precipitate the first psoriatic skin lesions in a genetically susceptible
individual, or induce flares in patients in remission. These include excessive alcohol ingestion, smoking, obesity,
stress and pregnancy.
Infections are a common precipitating factor in about 25% of patients and more than 50% have exacerbations within
3 weeks after an upper respiratory infection (bacterial, viral, HIV). The guttate variant is often associated with
infections of group A beta-hemolytic Streptococcus.
Trauma may precipitate psoriasis. The Koebner phenomenon is the appearance of psoriatic lesions at the site of
injury within a day to several weeks (average 10–14 days) after localized trauma. This response may be induced by
various types of trauma including rubbing, venipuncture, acupuncture, bites, surgery and mechanical pressure.
Climate can influence psoriasis. While most patients with psoriasis (80%) improve with warm seasons and
ultraviolet light, a small percentage (approximately 10%) worsen in the summer, and relapses may be triggered
paradoxically by ultraviolet light exposure. Ninety percent of patients report worsening in cold weather.
A summary of differential diagnosis and management of psoriasis is provided in Table 1.
Psoriasis is often confused with dandruff and seborrhea, especially when present on the scalp. See Dandruff and
Seborrheic Dermatitis, Table 3: Comparisons among Dandruff, Seborrhea and Psoriasis, for a comparison of the
differences between the 3 conditions with respect to other determinants.
Table 1: Psoriasis: Differential Diagnosis
Form Characteristics Differential Diagnosis Action
Chronic Forms of Psoriasis
Plaque Classic form: Sharply Nummular eczema Diagnosis should be

defined erythematous Atopic dermatitis confirmed by qualified
papules which coalesce; practitioner
covered with distinctive Drug reactions
Self-care management if
silver scale when untreated T-cell lymphoma mild
Auspitz sign—punctate
bleeding points when scale
removed
Localized: Extensors (arms
and legs), scalp, ears,
palms, soles
Generalized: (face, trunk,
flexures) or one site
with/without nails, nail pits
—loss of colour, thickening,
distal destruction
Inverse In body folds and flexures Intertrigo areas (skin folds) Diagnosis should be
(flexural) No scale Tinea in males (active confirmed by qualified
border) practitioner
Demarcated erythema
Candida in females (satellite
pustules)
Contact dermatitis—allergic
or irritant (location of
contact)
Scalp Silvery scale, discrete Seborrhea Diagnosis should be

margins, extends beyond confirmed by qualified
the scalp margins; may practitioner
accompany any form or Self-care management if
may be the only visible sign mild
Acute and Subacute Forms of Psoriasis
Guttate Small, discrete, Pityriasis rosea Diagnosis should be

erythematous papular Secondary syphilis confirmed by qualified
lesions; appears suddenly practitioner
after upper respiratory tract Pityriasis lichenoides
infection (streptococcal) in
children or young adults;
may be the initial
presentation; takes months
to resolve
Form Characteristics Differential Diagnosis Action
Pustular Local (palms and soles): Chronic dyshidrotic eczema Diagnosis should be
Chronic in women who —itch is predominant vs pain confirmed by qualified
smoke; stable but in psoriasis practitioner
troublesome
Systemic: Uncommon but
serious, starts with
systemic signs and
symptoms such as fever,
leukocytosis, general
malaise, followed by
pustules (2–3 mm) on
erythematous skin; may
generalize and require
hospitalization;
corticosteroids are
contraindicated
Erythrodermic Generalized erythema Atopic dermatitis Diagnosis should be

without any characteristic Drug reactions can present confirmed by qualified
lesions as severe skin disorders practitioner
Drug-induced Psoriasis
Drugs aggravating psoriasis include alcohol, antimalarials, beta-blockers, lithium, NSAIDs and oral corticosteroids;
beta-blockers have been implicated in stimulating an initial episode (Table 2).6,9,10
Table 2: Drugs Known to Trigger Psoriasis

ACE inhibitors Chloroquine Glyburide Penicillamine
Acebutolol Chlorthalidone Gold Phenylbutazone
Amiodarone Cimetidine Hydroxychloroquine Pindolol
Amoxicillin Clomipramine Ibuprofen Propranolol
Ampicillin Clonidine Indomethacin Pyrazolones
Arsenic Cyclosporine Interferon-alfa Sotalol
ASA Diclofenac Ketoprofen Sulfamethoxazole-
Atenolol Digoxin Labetalol trimethoprim
Auranofin Dipyridamole Levamisole Sulfonamides
Aurothioglucose Enalapril Lithium Tacrine
Beta-blockers Fluoxetine Metoprolol Terbinafine
Bisoprolol Gemfibrozil Nadolol Tetracycline
Captopril Glipizide NSAIDs Timolol
Chlorambucil Omeprazole Trazodone
Assessing Severity of Psoriasis
Only mild, chronic forms of plaque and scalp psoriasis can be managed with self-care after an appropriate
diagnosis. All other types of psoriasis require investigation, diagnosis and treatment under the care of an
appropriate healthcare practitioner (Table 1).
Parameters for assessment of the severity of psoriasis include:

Body surface area (BSA): The total BSA involved is an important factor in determining severity of psoriasis. The
area covering the patient's palm and thumb from wrist to fingertips is estimated to be 1% of total BSA. The
National Psoriasis Foundation considers up to 3% BSA as mild psoriasis, 3–10% as moderate and >10% as
severe
Location of lesions: Location of lesions can determine the social or economic impact of the disease. Hands,
forearms and particularly face involvement may be disabling. Caution with selection of topical agents is
warranted when treating lesions in areas in which there may be greater absorption of medication (e.g., face,
eyelids, self-occluded areas) or in locations where thickness of the skin diminishes penetration of medication
(e.g., palmoplantar areas)
Types of lesions: Scale, erythema, thickness of plaques (see Table 1).
Various tools are used by healthcare practitioners to determine severity of disease, impact on quality of life and
response to treatment. The 2 most established tools for assessing severity are the Psoriasis Area and Severity Index
(PASI) and the Dermatology Life Quality Index (DLQI). These tools and others are summarized as follows:
Psoriasis Area and Severity Index (PASI): Quantitative tool to measure body surface area involvement, scaling,
erythema and thickness of plaques in order to assess clinical changes in response to treatment16
Dermatology Life Quality Index (DLQI): A global scale used to measure the health-related quality of life of adult
patients suffering from a skin disease.17 Quality of life indicators represent patients' perceptions and reactions
to their health. Assessing patients' impairment in everyday living is an essential outcome measure in evaluating
the impact of psoriasis on quality of life. Another quality of life instrument called Skindex-29 may have greater
sensitivity to clinical severity, particularly in mild psoriasis18,19
Physician's Global Assessment (PGA): A key three-item (erythema, induration, and scaling) measure frequently
used to classify severity as clear, nearly clear, mild, moderate, severe or very severe. Validity has been
substantiated with correlations to the Psoriasis Area and Severity Index (PASI)20
Simplified Psoriasis Index (SPI): Used in specialist settings, this appears to be a valid and reliable psoriasis
assessment tool18
Visual analogue scale: Reported to be a useful method for patients to assess psoriasis severity21
Nail Assessment in Psoriasis and Psoriatic Arthritis (NAPPA) and Nail Psoriasis Severity Index (NAPSI): Both of
these tools appear to be valid, reliable and practical options for assessing patient-relevant nail psoriasis
outcomes.22
An integral component of psoriasis prevention and control is to address environmental and lifestyle risk factors, to limit
progression and reduce frequency and severity of relapses. Patients must be aware of triggers such as streptococcal
infections, drugs, trauma or injury, low humidity and emotional stress.23
Smoking cessation, minimizing alcohol intake and maintaining a healthy diet are advised, to counteract metabolic
syndrome and cardiovascular risk factors.
A restricted diet, with or without the addition of physical exercise, can reduce psoriasis severity and improve health-
related quality of life in overweight or obese patients with psoriasis.18,24
Activities that promote relaxation and mindfulness have been shown to reduce flares.25 Computerized or online
cognitive behavioural therapy (CCBT) for people with psoriasis appears to reduce anxiety and increase quality of
life.18,26
Advise patients to avoid skin irritants such as soap. Bathing and use of a cool air humidifier can be beneficial. Aqueous
creams can serve as cleansers and emollients as skin should stay moist. Caution patients about removing scale, which
could trigger a flare. Nonmedicated products such as emollients help retain moisture in the skin by forming a film over
the surface and can be used liberally without concern of side effects. A study evaluating the effect of an emollient on
patients with mild plaque psoriasis during and after standard local corticosteroid therapy reported that use of an
emollient can limit relapses after the end of 1 month of corticosteroid therapy, and maintain the improvement in skin
symptoms.27
For further information regarding the treatment of psoriasis, consult the Compendium of Therapeutic Choices: Psoriasis.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Skin
Care Products: Dermatitis and Dry Skin, Psoriasis.
Pharmacologic treatments that address management of pathophysiological factors such as modulation of immune
abnormalities and cell turnover are combined with nonpharmacologic measures (see Nonpharmacologic Therapy).
Topical treatment is first-line therapy for patients with mild, localized plaque psoriasis when total body surface affected
is <5%.28 Topical therapy is primarily directed toward altering the immune mechanism of the disease, with secondary
attention to reduction and removal of scale, inflammation and dryness.
Systemic agents, alone or in combination with topical treatment, are reserved for more moderate to severe, widespread
symptoms.
Patients with more resistant psoriasis may benefit from combination, rotational or sequential therapy. Combination
therapy is used to maximize clinical results from agents acting by different mechanisms and to minimize side effects.
Rotational therapy decreases cumulative toxicity by switching between medications with differing toxicity but is more
commonly used with systemic therapies. Sequential therapy is instituted when medications are used in a set sequence
to maximize the initial speed of improvement while minimizing long-term toxicity.
Due to the chronicity of the disease, once control is achieved it is important to reduce treatment to the least potent and
least toxic regimens that maintain control.
Endorsed treatment guidelines that outline current standards of care are published by American,28,29,30,31 British,32
Canadian33 and European34 consensus groups.
Adherence: Approximately 40% of patients with psoriasis report nonadherence to treatment, and 50% of psoriasis
prescriptions are reported to be unfilled. Reasons include frustration with efficacy, inconvenience, fear of side effects,
cost, cosmetic distaste, and unclear or complicated instructions. Approaches to enhancing adherence include involving
the patient in decision making, choosing acceptable vehicles, use of fast-acting agents early in the course of therapy
and transitioning to longer-acting, safer options for long-term management, intermittent use of corticosteroids with
corticosteroid sparers, and use of clear, written instructions. Keeping in contact with the patient to address concerns is
important and should be initially done early, especially if treatment is time consuming and difficult, such as with scalp
psoriasis.35 A psoriasis symptom diary demonstrated favorable psychometric properties and is a brief, useful tool for
measuring symptoms and the impact of chronic plaque psoriasis.36 Text message interventions are a promising tool,
leading to an increase in adherence to therapy, positive changes in self-care behaviours and better patient-physician
relationships fostering improved clinical outcomes and better control of the disease.37
Application of appropriate amounts of topical agents can be aided by the use of tools that help to estimate quantities
for each application depending on age and body parts affected. To determine the quantity of topical agents required for
treatment, the fingertip unit is a practical approach. One fingertip unit is approximately 0.5 g (estimated to be the
amount squeezed from a tube with a standard 5 mm nozzle from the fingertip to the first crease of an adult finger). This
amount is sufficient to cover one hand (front and back) or about 2% of BSA. The trunk (front and back) is about 30%
BSA; to cover the entire trunk once, about 15 fingertip units, or 7.5 g, would be required.38 For a table that lists the
number of fingertip units required for various body parts in different age groups, consult the Compendium of Therapeutic
Choices: Atopic Dermatitis, Table 3. A second tool that can be used for estimating the amount of cream required to treat
specific body areas is based on the Rule of Nines (see Figure 1).
Figure 1: Amount of Cream Required for TID Application × 10 Days
a Rule of Nines: 9 g of cream covers 9% of skin area daily (based on TID application).
Type of Vehicle
The vehicles in which active topical ingredients are applied may have considerable influence on therapy. Topical
therapies are available as creams, foams, gels, liquid solutions, lotions, ointments and drug-impregnated tapes. The
appropriate vehicle depends on the location of the lesions, the patient's symptoms and the patient's preference.
Ointment vehicles are occlusive which makes them generally more effective at maintaining hydration of the skin and
facilitating drug absorption. They may be preferred in the evening when patients have more time to apply medication
and are less worried about staining. Fissured lesions on the palms and soles may improve with the use of ointment
vehicles. Creams spread more easily and quickly, are more quickly absorbed and do not produce a greasy effect on
clothes. Patients may prefer these for work or school, reserving ointments for use at night. Lotions and foams are
easier to apply and remove from the skin and more soothing for itching skin, but are more drying. Gels provide drying
and cooling effects, are cosmetically acceptable, and diffuse throughout and remove easily from the scalp while
concentrating drug delivery by evaporation. Patients with fissures or cracked lesions will complain of stinging pain if
alcohol-based solutions or foams are used.
The location of the psoriasis may assist in selection of vehicle. For the scalp, gels, foams, solutions and lotions are
typically better, except in some black patients with curly hair who may respond best to gels and liquids specifically.
In intertriginous areas such as axillae, groin and inframammary folds, lotions or creams are more comfortable than
ointments. Climate also influences choice: lotions and creams are better tolerated than ointments in warm moist
environments, while ointments are preferred in dry or cold climates.
Enhancement of penetration of active drug can be accomplished in various ways. An occlusive base may enhance
penetration of active drug and inhibit cell division. Medicated creams, lotions and gels can be occluded to enhance
drug penetration and potency if required. This is accomplished by covering the medicated area with plastic wrap,
plastic baggies, thin plastic gloves, or with fabric such as a sock or cotton gloves. This technique is often used with
corticosteroids for psoriasis involving soles, hands and extremities. Keratolytics such as salicylic acid or sulfur may
remove scale that is limiting penetration. Specific agents such as urea or propylene glycol may promote penetration
by enhancing permeability of the stratum corneum.39
Chronic Plaque Psoriasis of Trunk and Extremities
See also Table 4 and Figure 2 for management of chronic plaque psoriasis.
Topical Therapy
Topical corticosteroids are an integral component of psoriasis treatment because they are effective and well
tolerated despite adverse effects. Corticosteroids have anti-inflammatory, antiproliferative, immunosuppressive and
vasoconstrictive effects, as a result of binding to intracellular corticosteroid receptors and regulation of gene
transcription. They are considered first line in the treatment of mild plaque psoriasis, and an adjunct to systemic
therapy in more severe forms.28,40
Advantages of corticosteroids are fast onset and ease of use. Comparative studies have not shown superiority with
respect to potency, frequency of application or formulation. In general, higher potency corticosteroids are
considered more effective than low-potency agents, especially for thicker plaques. Occlusion with gloves or plastic
wrap overnight provides added benefit. A systematic review that examined randomized trials comparing topical
treatments with placebo or vitamin D3 analogues (alone or in combination) in patients with chronic plaque psoriasis
concluded that corticosteroids perform at least as well as vitamin D3 analogues, and are associated with a lower
incidence of local adverse events. There is little evidence concerning the risk of dermal atrophy for individuals with
chronic plaque psoriasis receiving long-term corticosteroid treatment.41
Choice of potency depends on severity and location of the disease. Pediatric and elderly patients have thinner skin
and are more susceptible to atrophic effects of stronger corticosteroids. Only hydrocortisone should be used on the
face or in the intertriginous folds to avoid skin atrophy and other side effects. Plaques of psoriasis on the trunk and
extremities are often treated with mid-potency topical corticosteroids. Stronger topical corticosteroids such as
those 9–12 times more potent than hydrocortisone may be necessary for shorter periods (e.g., 2-week intervals) on
the palms and soles. Ultrapotent corticosteroids may increase the risk of adrenal suppression. Apply the
corticosteroid in a thin layer, since only that which touches the skin is absorbed.
Cutaneous adverse effects include skin atrophy, acne, contact dermatitis, hypertrichosis, folliculitis,
hypopigmentation, perioral dermatitis, striae, telangiectases and traumatic purpura. These are unlikely while
corticosteroids are being applied to active lesions. Systemic adverse effects have been reported not only with
ultrapotent corticosteroids but also with extended or widespread use of mid-potency agents. Systemic adverse
effects include hypothalamic-pituitary-adrenal (HPA) axis suppression. Less commonly, Cushing’s syndrome,
osteonecrosis of the femoral head, cataracts and glaucoma may occur.28,33 Potential benefits may warrant use of
topical corticosteroids in pregnant women despite potential risks.33
Topical corticosteroids seldom produce long remissions, and psoriasis tends to rebound promptly when they are
withdrawn with a mean remission time of 2 months. Once clinical response is achieved, options for tapering to
maintain control include less frequent use of the corticosteroid, switching to a less potent agent, intermittent
therapy (e.g., 2–3 times weekly) or pulse dosing (e.g., 3 consecutive doses at 12-hour intervals, once weekly).
Topical corticosteroids should be supplemented or substituted with corticosteroid-sparing agents such as plain
petrolatum, salicylic acid, tar, anthralin, calcipotriol or tazarotene to decrease the frequency of corticosteroid
application.
Corticosteroid-sparing agents are products used in combination with corticosteroids, intermittently and alternately,
to reduce risk of side effects from corticosteroids. Corticosteroids are relatively fast in onset; corticosteroid-sparers
may take longer to work but enhance long-term maintenance and therefore should be initiated at the same time as
the corticosteroid.
One of the simplest corticosteroid-sparing agents is petrolatum. It can be used to replace 1 out of every 4
applications of corticosteroid initially. As psoriasis improves after 2–6 weeks, gradually increase the number of
applications until it almost completely replaces topical corticosteroids. Petrolatum has an antiproliferative effect on
epidermal cells and will help diminish surrounding skin irritation from other corticosteroid-sparing agents if applied
in a ring around psoriatic plaques.
Salicylic acid is a keratolytic agent useful in the treatment of mild to moderate psoriasis. It is a good adjunct to other
topical medications, but not used as monotherapy because it only removes scale. It is available in concentrations of
2–10% in various vehicles including gels, creams and shampoos. Since salicylic acid breaks down keratin topically, it
increases percutaneous absorption of topical corticosteroids. This may be a safe and effective alternative when
other treatment modalities are too toxic or not an option. Salicylic acid will increase the penetration of
hydrocortisone approximately threefold, and desoximetasone, triamcinolone-acetate and fluocinonide twofold or
more.42 Efficacy is increased with other such combinations; e.g., combination with mometasone furoate showed
more significant response after 21 days than with the corticosteroid alone.43 It has been suggested that salicylic
acid–topical corticosteroid combinations be used as first-line therapy on psoriasis plaques that are thick, scaly or
recalcitrant to topical corticosteroids alone. A caveat is that salicylic acid should be used with caution in patients
with greater than 20% BSA involvement.44 It may cause salicylate toxicity in these cases; signs of toxicity include
tinnitus, fatigue and GI symptoms, reversible when salicylic acid is discontinued. Hypoglycemia in patients with
diabetes is a risk with application of salicylic acid to large body surface areas; alternative keratolytic acids such as
lactic acid or urea should be considered.42 Salicylic acid can be added to most topical corticosteroids in
concentrations of 3–5%; apply a 1-month expiry date to cream formulations. Salicylic acid is also used in
combination (urea 10%/salicylic acid 5% ointment) as a corticosteroid-sparing alternative. Salicylic acid has been
used successfully in combination with anthralin. It should not be used with calcipotriol, since it will inactivate
calcipotriol upon contact. It also blocks UVB and should not be applied prior to ultraviolet therapy.42 Salicylic acid
use should be avoided in children; however, it may be used for limited and localized plaque psoriasis in pregnancy.28
Lactic acid is another less common topical keratolytic agent used in the treatment of psoriasis. It is an alpha-
hydroxyacid reserved as a second-line agent in patients with diabetes when salicylic acid treatment is a concern.
Lactic acid is effective, proven to enhance desquamation of normal skin, and can be used on a larger surface area.42
Crude coal tar is the liquid byproduct of the distillation of bituminous coal and contains more than 10 000
ingredients whose exact mechanism of action is yet unknown. It is a useful agent in mild psoriasis as it decreases
epidermal hyperproliferation, is anti-inflammatory and antipruritic, and may be antimicrobial. It is a frequently used,
inexpensive, safe and effective topical preparation, producing clearing with long remissions. Concentrations of 0.5–
10% are used in ointments, creams, lotions, shampoos, gels, solutions and soaps. Modified tar extracts incorporated
into solutions and gels are less effective, although cosmetically superior and ideal for scalp psoriasis. Crude coal tar
4% is equivalent to the tar distillate, liquor carbonis detergens (LCD) 10–20%. Shampoo products often contain both
coal tar and salicylic acid to maximize efficacy. Coal tar 5–10% can be added to corticosteroid ointments and
creams if a 1-month expiry date is affixed. Most applications are designed for once-daily use at night, but may be
used more often if the patient is willing. The photosensitizing action of tar enhances its efficacy in psoriasis:
pretreatment for 2 hours is followed by ultraviolet B light treatments in ambulatory clinics (Goeckerman
routine).45,46 A systematic review found one study showing that daily coal tar shampoo was no more effective than
placebo; however, most patients had moderate to severe psoriasis41 and therefore the results may not be
generalizable to patients with mild disease for which topical therapy is the mainstay of treatment. Another study
found coal tar to be significantly less effective than betamethasone valerate in patients with stable mild to moderate
psoriasis.47 Coal tar appears to have comparable clinical efficacy to calcipotriol, but calcipotriol has a faster onset
of action and is better tolerated.33
Coal tar may be a reasonable option for long-term maintenance and treatment of mild to moderate psoriasis. It is
safe to use and is inexpensive and widely available in shampoos and solutions ideally suited for use on the scalp;
however, it also has obvious disadvantages and side effects. These include staining of clothes and furniture, messy
application, unpleasant odour, contact sensitivity, burning sensations, photosensitivity and tar folliculitis. Application
in circular motions may cause folliculitis or acne; this can be diminished by applying the tar in downward linear
strokes in the direction hairs sit flat against the skin which minimizes inflammation and irritation in the hair follicles.
The higher the tar concentration, the greater the irritancy. Though tar is effective, patients may find it difficult to
adhere to treatment due to its side effects and prolonged treatment durations of 2–4 weeks. There are no reported
systemic side effects despite decades of use. The FDA has concluded that coal tar in concentrations and
formulations used in nonprescription products (0.5–5%) does not pose a risk of carcinogenicity.42 Due to lack of
evidence of safety and concerns of potential mutagenic effects, some sources recommend avoiding coal tar during
pregnancy,48 while others feel it is likely safe during the second and third trimesters.33,49 Coal tar should be avoided
during breastfeeding due to risk of absorption by the infant via skin-skin or skin-mouth contact.50
Anthralin is a less commonly used topical treatment for psoriasis; however, it is appropriate and effective in specific
situations. The mechanisms of action of anthralin (dithranol) are multiple. It is antiproliferative as it normalizes
keratinocyte differentiation by promoting keratinocyte apoptosis, decreasing cell respiration and inhibiting
inflammation. It may have a direct effect on mitochondria, reduce mitotic acitivity and prevent T-lymphocyte
activation.51 Anthralin is most useful for thinning plaques and is associated with a remission time of 3.9 months.52
It was superior to calcipotriol in a study of 106 patients.53 Conventionally, anthralin is applied once daily to skin or
scalp, allowed to remain overnight, and followed by bathing or shampooing the next morning. Short-contact therapy
(15–30 minutes followed by washing) is also effective and may be less irritating than once-daily use.53 Effects may
be increased in ambulatory patients through the addition of ultraviolet light (Ingram routine).42 In this method,
anthralin is applied, covered with talcum powder then gauze, wiped off after an interval of time, followed by a tar
bath and then ultraviolet light. This is effective but time-consuming and therefore usually reserved for unresponsive
psoriasis. Problems with anthralin include burning, stinging, dryness and most importantly, staining of skin, clothes
and furniture and discolouration of blond hair. Careful application to affected areas only is important, as surrounding
skin is easily irritated through contact. Lesions can be ringed with zinc oxide paste or petrolatum to protect
surrounding skin. If compounding with dry anthralin powder, avoid skin contact by wearing gloves. Alternating
combinations of tar then anthralin are less irritating, and addition of corticosteroid to uninvolved surrounding skin
also reduces irritation. Triethanolamine, a neutralizing agent, placed on unaffected skin 1–2 minutes before
anthralin is removed, and again after towel drying, also reduces staining and inflammation. Other adverse effects
include folliculitis and allergic contact dermatitis, but these are uncommon. There are no systemic or long-term side
effects and anthralin has been used safely for many years; staining is the major limitation. Anthralin is
contraindicated on the face, in flexures or on the genitals, where irritation is excessive. It may be alternated with
topical corticosteroids. Safety of anthralin in pregnancy has not been confirmed.
Calcitriol and calcipotriol are vitamin D3 analogues, which enhance keratinocyte differentiation and inhibit
proliferation and cytokines. Response is slow; a period of 2 months is usually required to see best effects. These
agents maintain effectiveness without tachyphylaxis.16 A systematic review found efficacy of vitamin D3 analogues
similar to corticosteroids when used on the body. Combination treatment with both vitamin D3 analogues and
corticosteroids was more effective than either treatment alone. Corticosteroids also seemed to be better tolerated
than vitamin D3 analogues.54
Tazarotene, a receptor-selective topical retinoid, is a corticosteroid-sparing agent that appears to inhibit keratinocyte
proliferation, regulate differentiation and modify inflammatory infiltration in the plaque. It is effective in clearing
psoriatic plaque lesions and achieving remission.28 Retinoids are less effective than corticosteroids as topical
treatments.41
Topical calcineurin inhibitors are a treatment option for patients with limited psoriatic manifestations. Tacrolimus
ointment and pimecrolimus cream are derivatives of cyclosporin that inhibit calcineurin, thereby blocking the
synthesis of inflammatory cytokines and further activation of T cells that contribute to psoriasis. They are not
approved for the treatment of psoriasis, but are considered useful for treating thin skin or fold areas, despite
minimal published data on use or effectiveness. They are reserved as an option for recalcitrant plaques of the face,
genitals and intertriginous areas, where use of potent topical corticosteroids or irritating agents are of concern.33,55
Systemic Therapy
If psoriatic symptoms are more severe and/or too extensive for topical therapy, systemic therapy is preferred, with
topical therapies remaining as useful adjuncts. Methotrexate, cyclosporine and acitretin are the oral agents
traditionally used. Biologic response modifiers are effective and have relatively good tolerability but their high cost
means other systemic therapy is generally tried first.33
Ultraviolet radiation, which inhibits epidermal mitosis, can be very useful in more severe, extensive or resistant cases
of psoriasis, in addition to topical therapy, such as tar or anthralin. Phototherapy uses either UVA or UVB light. UVA is
given with a photosensitizer, such as oral or topical psoralens, to enhance efficacy. This is called PUVA (psoralen +
UVA). UVB is used alone as either broadband (BB-UVB) or narrowband (NB-UVB); the latter is preferred. BB-UVB is
also given as photochemotherapy with topical agents such as crude coal tar or anthralin for enhanced efficacy. NB-
UVB is commonly used with adjunctive topical treatments such as emollients, calcipotriene, corticosteroids,
retinoids and tar.56 Although NB-UVB is slightly less effective than PUVA (which benefits the majority of patients and
has the potential to induce long remissions), NB-UVB is generally preferred due to less toxicity, no need for
photosensitizer medication and ease of administration. Adverse effects of phototherapy include erythema pruritus,
xerosis, hyperpigmentation and blistering, especially with higher dosages. Oral psoralens can cause nausea and
vomiting. Long-term PUVA use can induce photoaging and a potential for increased cataract formation (psoralens
bind to lens proteins). The concern of carcinogenesis linked to long-term light therapy (dose-related), especially
PUVA, has led to recommended limits on total cumulative dose.28,31,33
Methotrexate, a folic acid antagonist, is an immunosuppressant effective in treating both psoriasis and psoriatic
arthritis; it is given once weekly. There is significant associated liver and bone marrow toxicity.57 Methotrexate's
efficacy is greater than acitretin and equal or slightly inferior to cyclosporine. With appropriate monitoring for
adverse effects, methotrexate can be used for years with sustained efficacy.33
Cyclosporine is a systemic calcineurin inhibitor, efficacious for both inducing remission and as maintenance therapy
for patients with moderate to severe plaque psoriasis. It is also effective in treating pustular, erythrodermic and nail
psoriasis. It is associated with significant side effects, particularly renal toxicity and hypertriglyceridemia, and
therefore should be reserved for intermittent use only (up to 12 weeks at a time) to decrease risk of toxicity.33
Acitretin is an oral retinoid (vitamin A acid derivative) used in pustular or erythrodermic psoriasis. It has no
immunosuppressive effects and its efficacy in psoriasis is probably due to modulation of cellular differentiation in
the epidermis leading to re-establishment of a more normal pattern of cell growth. It is generally reserved for
patients with moderate to severe disease who have not responded to other therapy and is commonly combined with
topical vitamin D3 analogues or phototherapy. Adverse effects include severe mucocutaneous drying,
hypertriglyceridemia, and risk of teratogenicity that can remain a concern for up to 3 years after stopping acitretin.
Biologic response modifiers are the most effective agents for treatment of psoriasis but they are much more
expensive than traditional systemic agents. Those approved in Canada for treatment of psoriasis include
adalimumab, etanercept, infliximab, secukinumab and ustekinumab. Coverage by drug plans is often reserved for
patients who have failed 2 traditional systemic agents (including phototherapy). Biologics may be used in
combination with another systemic agent, especially methotrexate, if the response to monotherapy is inadequate.
Biologic response modifiers provide a selective, immunologically directed intervention with fewer major organ
toxicities. Adverse effects include increased risk of infections and development or worsening of autoimmune
diseases or malignancies.57,58
Apremilast is an oral phosphodiesterase 4 inhhibitor that has immunosuppressant effects resulting in decreased
inflammatory cytokines. It appears to be less effective than cyclosporine and biologic response modifiers and is
expensive. It is relatively well tolerated and does not require routine bloodwork.59,60
Flexures and Face
Absorption of topical corticosteroid through the skin is greatly increased in flexure areas and the face; only
hydrocortisone should be used in these areas. Psoriasis in the flexures (inverse psoriasis) poses unique therapeutic
challenges since the impact does not relate to total body surface area. Topical hydrocortisone is the mainstay of
therapy. If psoriatic lesions in the flexures become infected with tinea or Candida, hydrocortisone powder can be
added to topical imidazole (e.g., clotrimazole, miconazole) creams, or the 2 creams (hydrocortisone and the
imidazole) can be used in succession. Imidazoles have anti-inflammatory, antifungal and some gram-positive
antibacterial effects. Stronger agents are sometimes used for recalcitrant cases.12 The topical calcineurin inhibitors
pimecrolimus and tacrolimus are effective and well tolerated in psoriasis of the face and flexures, though they are
not approved for this indication.33
Scalp
Scalp treatments should involve 4 stages: descaling, active clearing, stabilization and long-term maintenance. They
include the use of shampoos as vehicles for active agents and to remove scale, tar preparations with or without
salicylic acid, anthralin, topical corticosteroids, vitamin D3 analogues or tazarotene gel. A systematic review found
that topical corticosteroids alone or combined with vitamin D3 analogues were both more effective than vitamin D3
analogues alone. Since safety profiles were similar and combination products provided only a slim benefit over
corticosteroids alone, monotherapy with topical corticosteroids is a reasonable, less expensive approach.61
Scalp treatments can be applied on a damp scalp after towel drying, or on a dry scalp; the agent must reach the
scalp lesions, not just the hair. Water-washable vehicles are preferred. Bath oil with surfactant can be used to assist
in scale removal and as a vehicle for coal tar or other active agents, usually overnight. Active medications are often
applied at night and shampooed out in the morning. Therapeutic agents must be left on the scalp after the shampoo
and not used before. The topical product should be rubbed in to leave a thin film, not leaving a thick or visible
coating.
Keratolytics, which decrease scale, should be left on for a minimum of 5–10 minutes, or overnight, and covered with
a shower cap. After rinsing, corticosteroid lotions or gels can be applied, reserving higher potencies for pulse
therapies of 2 weeks in resistant cases. Cytostatic antifungal preparations such as ketoconazole, selenium sulfide
and zinc pyrithione are generally not suitable for treatment of psoriatic scalps. Use of imidazole antifungals remains
controversial, since Malassezia fungus may be present in persistent nonresponsive psoriasis; use should be
determined by positive culture.11
Palmoplantar
Palmoplantar psoriasis can be limited in extent (generally 4% of total body area) but have devastating impact due to
pain, debilitation and social stigmatization, interfering with dexterity and mobility. Therapy must address alteration in
quality of life. Protective measures such as shielding lesions from physical triggers are essential. Altered barrier
function enables the Koebner phenomenon (see Risk and Aggravating Factors), adding to aggravation of lesions.
Avoid harsh cleansers and contact with chemicals, solvents, fruit and vegetable juices. Protective cotton gloves
should be worn. Emollients, especially in oil or ointment bases, help maintain barrier function, but suboptimal, less-
greasy vehicles may be used to improve patient acceptance, provided they lack irritants (e.g., lanolin, fragrance,
preservatives, see Atopic, Contact, and Stasis Dermatitis). Topical corticosteroids are the mainstay of treatment,
used with nighttime occlusion or keratolytic agents. Topical calcipotriol or tazarotene may be used; phototherapy
may be used if topical agents are ineffective (PUVA more effective than UVB).62
For more information on the treatment of psoriasis, consult the Compendium of Therapeutic Choices: Psoriasis.
Psoriasis and Vaccinations

With the exception of acitretin, vaccine administration may be problematic with the use of systemic agents for
psoriasis because of their immunosuppressive effects. An inadequate immune response may decrease
effectiveness of an inactivated vaccine or lead to infection with live attenuated vaccines. Vaccination should take
place before starting immunosuppressants if possible; wait 14 days after vaccination with an inactivated vaccine to
ensure immunogenicity and 4 weeks after a live vaccine to reduce the risk of infection caused by the vaccine strain.
If a patient already taking immunosuppressants (except high-dose systemic corticosteroids) requires an inactivated
or live vaccine, the immunosuppressant should be stopped for 3 months prior to vaccination. High-dose systemic
corticosteroids should be stopped for 4 weeks prior to vaccination.63 Immunosuppressants should be held during
serious or febrile illnesses including pneumonia, wound infections and cellulitis, but can be continued through
uncomplicated upper respiratory tract infections or cystitis.40
Complementary and Alternative Therapies
The use of complementary and alternative medicine (CAM) among patients with psoriasis is common, with a
prevalence of 43–69% in various studies. Most of these patients use natural health products, special diets or dietary
supplements in conjunction with their usual antipsoriatic medications and not as replacements.64 Natural health
products such as aloe vera, beta-carotene, zinc, selenium, vitamin B complex, flax seed oil, yellow dock, horsetail,
lavender and ginger (in the bath), as well as acupuncture, ayurveda and magnets (see Complementary and
Alternative Therapies), have been promoted in the media or on Internet sites. Since these treatments lack controlled
studies of their efficacy, side effects or interactions with recommended treatments, they should not be
recommended. Psoriasis sufferers, due to distress over their condition, may turn in desperation to the Internet and
other nonregulated sources of information. “Miracle cures” touted on the Internet may in fact worsen a patient's
condition. A systematic review found the quality of most CAM studies was low.
Agents or interventions with documented clinical efficacy included:64

Mahonia aquifolium (Oregon grape) contains berberine as the primary active constituent in the rhizome and
root. This alkaloid inhibits keratinocyte growth and proliferation, and has antibacterial and antifungal activities.
In 2 clinical trials Mahonia aquifolium was efficacious in reducing disease severity compared with placebo
Fish oils have demonstrated efficacy in comparative trials. Long-chain polyunsaturated fatty acids,
eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), compete with arachidonic acid for
cyclooxygenase and lipoxygenase, reducing proinflammatory molecules in psoriatic plaques. One study
comparing EPA plus etretinate with etretinate monotherapy found significantly greater efficacy with the
combination of EPA plus etretinate65
Climatotherapy refers to the practice of traveling to sunbathe and/or bathe in the Dead Sea. Two studies using
high- or low-concentration saline spa baths plus UVB showed response was significantly better with the saline
spa bath plus UVB combination. Bathing in geothermal seawater combined with narrow band UVB therapy in
psoriasis induced faster clinical and histological improvement, produced longer remission time and permited
lower UVB doses than UVB therapy alone64,66
Stress-reduction techniques show inconsistent benefit. One randomized study demonstrated that both
meditation or meditation plus imagery were efficacious as adjunctive treatments for patients with scalp
psoriasis. A second showed the addition of a mindfulness-based stress-reduction audiotape played during light
treatments reduced response times for patients receiving UVB but not PUVA therapy.64
Table 3 presents a monitoring framework for patients. Parameters should be monitored by the patient in a diary. Scale
will improve quite quickly with cosmetic treatment and hygiene control; thickness of scale will improve more slowly and
erythema will take longest to respond.
Monitor the side effects of drug therapy. If allergic reactions occur, discontinue therapy. If the condition worsens due to
irritation, therapy should be altered. Failure to meet the listed end points should result in alteration of dosage or drug
therapy. Therapy should be appropriately tapered in response to improvement or resolution.
Table 3: Monitoring of Therapy for Psoriasis

Parameter Monitoring frequency Time Frame/Degree of Actions
Change
(resolution/control; relief
of symptoms)
Scale Patient: Daily while on drug therapy Decrease by 50% within 7– Taper therapy in
Healthcare practitioner: After 2–3 wk 10 days response to
or next visit resolution; if end
points not achieved,
consider further
Thickness of Patient: Daily while on drug therapy Decrease by 50% within 6– therapy.
plaque Healthcare practitioner: After 2–3 wk 8 wk and by 75% within 8–
or next visit 12 wk
Redness Patient: Daily while on drug therapy Decrease by 50% within 8–

Healthcare practitioner: After 2–3 wk 12 wk and by 75% within
or next visit 12–16 wk
Surface area Patient: Daily while on drug therapy Decrease by 50% within 6–
involved Healthcare practitioner: After 2–3 wk 8 wk and by 75% within 8–
or next visit 12 wk
Extension to Patient: Daily while on drug therapy

other sites or Healthcare practitioner: After 2–3 wk
generalization or next visit
Itch/scratching Patient: Daily while on drug therapy Decrease to tolerable level

Healthcare practitioner: After 2–3 wk within 1–2 wk
or next visit
Disruption of Patient: Daily while on drug therapy Restoration of normal

sleep or daily Healthcare practitioner: After 2–3 wk patterns within 2–3 wk
activities or next visit
Stress, anxiety, Patient: Daily while on drug therapy Restoration of normal

depression Healthcare practitioner: After 2–3 wk patterns within 2–3 wk
or next visit
Progression of Patient: Daily while on drug therapy No progression of severity

severity Healthcare practitioner: After 2–3 wk
or next visit
Recurrent Patient: Daily while on drug therapy Lengthening of symptom-

episodes Healthcare practitioner: After 2–3 wk free periods throughout
or next visit therapy
Allergic Patient: Daily while on drug therapy If they occur,

reactions Healthcare practitioner: After 2–3 wk discontinue therapy.
or next visit
Severe Patient: Daily while on drug therapy Minimal If severe, decrease

dryness, Healthcare practitioner: After 2–3 wk Should disappear, diminish dose, concentration
irritation e.g., or next visit or be controlled with or frequency of use.
redness, continued use If still no
inflammation, improvement,
stinging consider alternative
treatment.
Resource Tips
A number of self-help support groups exist that can be accessed through the Internet.
National Institute of Arthritis and Musculoskeletal and Skin Diseases. Psoriasis. Questions and answers about psoriasis.
Available from: www.niams.nih.gov/Health_Info/Psoriasis/default.asp.
National Psoriasis Foundation. [email protected]. 1-800-723-9166. Available from: www.psoriasis.org.
The Psoriasis Association, which is a self-help organization founded in 1968, provides support and information on all
aspects of the condition. Available from: www.psoriasis-association.org.uk.
Algorithms
Figure 2: Suggested Approach for the Treatment of Psoriasis
Drug Table
Table 4: Topical Psoriasis Therapies
Anthracene anthralinb Short-contact Onset: Burning, Ingram routine $$$
derivatives cream, anthralin Requires 4 stinging, = anthralin plus
ointment therapy wk to see irritation. UVB.
(SCAT): 0.1–2 effect Staining of skin, Protect skin
% formulations Remission: clothes, around affected
are applied to Long furniture. area with
affected area Discolouration petrolatum or
for 15–30 min of blonde hair. zinc oxide to
then washed minimize
off irritation.
Traditional Avoid use on
dosage: 0.05– face, flexures or
3%. Apply HS genitals due to
and wash off irritation.
in the morning. If compounding
Start with with dry
lowest anthralin
strength and powder, gloves
increase should be worn.
gradually if
tolerated
Corticosteroids, clobetasone Apply BID–TID Onset: Burning, Moderate- $$

topical 17–butyrate Limit use to 2– Quick stinging, potency
0.05% cream 3 wk of Remission: dryness, corticosteroid
Spectro therapy on an Short pruritus. for use in mild
EczemaCare intermittent Striae, psoriasis on
Medicated basis telangiectasia, body areas
Cream Once control atrophy and other than face,
achieved, purpura can folds and
maintenance occur but are genitals (low-
dosing of once unlikely when potency
daily, 2–3 being applied to products
times per week active lesions. recommended
may be for these
sufficient areas).
To minimize
risk of adverse
effects
intermittent use
is
recommended,
often in an
alternating
fashion with
non-steroidal
topical
therapies.
Stronger
corticosteroids
may be
required on
thick-skinned
areas such as
palms or soles.
Corticosteroids, hydrocortisone Apply BID–TID Onset: Burning, Low-potency $
topical 0.5%, 1% Limit use to 2– Quick stinging, corticosteroid
cream, lotion, 3 wk of Remission: dryness, for use in mild
ointment therapy on an Short pruritus. psoriasis
Cortate, Emo- intermittent Striae, including on
Cort, Prevex basis telangiectasia, face, folds,
HC, generics Once control atrophy and genitals.
achieved, purpura can Ointments are
maintenance occur but are less
dosing of once unlikely when cosmetically
daily, 2–3 being applied to acceptable but
times per week active lesions. generally more
may be potent.
sufficient Absorption
greatest for
creases and
genitals, least
from palms and
soles. Use
occlusion with
caution.
Keratolytic coal tar cream, Use daily Onset: 4 Acne, contact The tar $
Agents emulsion, gel, Soaks for wk for full dermatitis, distillate, liquor
liquid, scale removal: effect photosensitivity, carbonis
ointment, Start with 5% Sustained unappealing detergens
shampoo and increase results odour. (LCD), is 20%
Denorex, as tolerated— with Stains skin and crude coal tar.
Liquor soak 5–10 min continued hair: cover with Additive
Carbonis application cotton/gloves. antimitotic
Detergens, Overnight to Apply in linear activity with
Targel, others soften scale: direction of hair UVA and UVB.
Apply prior to growth to avoid Coal tar plus
corticosteroids folliculitis—do UVB =
Tar is more not rub in Goeckerman
effective with circular motion. routine.
prolonged Contraindicated
contact time for diffuse,
acutely
inflamed or
open wounds.
When added to
corticosteroid
creams: 1-
month expiry
date.
Keratolytic salicylic acidb Lotion, cream, Onset: Irritation, Although $$$

Agents 3–10% cream, gel: Daily–BID Requires redness or approved for
gel, lotion, Shampoo: Use 2–4 wk to peeling. single use,
shampoo on scalp at see effect Irritating to most products
least twice mucous contain
weekly membranes salicylic acid in
massaging and eyes. combination
thoroughly with sulfur,
and/or coal tar.
Use at the Salicylic acid
interval enhances
necessary to penetration of
maintain topical agents
control of through
condition stratum
corneum.
a Cost of 50 g or 50 mL; includes drug cost only.

b Extemporaneously compounded preparations can be used.
Abbreviations: UVA = ultraviolet A ; UVB = ultraviolet B
Legend: $ <$10 $$ <$10–20 $$$ $20–30
Suggested Readings
Canadian Dermatology Association. Canadian Psoriasis Guidelines Committee. Canadian guidelines for the management
of plaque psoriasis. June 2009. Available from: http://www.dermatology.ca/wp-
content/uploads/2012/01/cdnpsoriasisguidelines.pdf
Menter A, Korman NJ, Elmets CA et al. Guidelines of care for the management of psoriasis and psoriatic arthritis.
Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies. J Am Acad
Dermatol 2009;60:643-59.
National Institute for Health and Care Excellence (NICE). Psoriasis: assessment and management. NICE guidelines
(CG153). Manchester: NICE; 2012. Available from: www.nice.org.uk/guidance/cg153.
Samarasekera EJ, Sawyer L, Wonderling D et al. Topical therapies for the treatment of plaque psoriasis: systematic
review and meta-analyses. Br J Dermatol 2013;168:954-67.
References
1. Gardner SS, McKay M. Seborrhea, psoriasis and the papulosquamous dermatoses. Prim Care 1989;16:739-63.
2. Parisi R, Symmons DP, Griffiths CE et al. Global epidemiology of psoriasis: a systematic review of incidence and
prevalence. J Invest Dermatol 2013;133:377-85.
3. Raychaudhuri SP, Farber EM. The prevalence of psoriasis in the world. J Eur Acad Dermatol Venereol 2001;15:16-
7.
4. Sobell JM, Geist DE. Psoriasis. In: Arndt KA, Hsu JT, eds. Manual of dermatologic therapeutics. 7th ed.
Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2007. p. 164-73.
5. Weller PA. Psoriasis. Med J Aust 1996;165:216-21.
6. Kadunce DP, Krueger GG. Pathogenesis of psoriasis. Dermatol Clin 1995;13:723-37.
7. Patel RV, Shelling ML, Prodanovich S et al. Psoriasis and vascular disease—risk factors and outcomes: a
systematic review of the literature. J Gen Intern Med 2011;26:1036-49.
8. Kirby B, Richards HL, Mason DL et al. Alcohol consumption and psychological distress in patients with
psoriasis. Br J Dermatol 2008;158:138-40.
9. Young DW, Downey DJ. Psoriasis: therapeutic aspects. N Z Med J 1993;106:63-4.
10. Guidelines for management of patients with psoriasis. Workshop of the Research Unit of the Royal College of
Physicians of London; Department of Dermatology, University of Glasgow; British Association of
Dermatologists. BMJ 1991;303:829-35.
11. Van de Kerkhof PC, Kleinpenning MM, Gerritsen RM. Scalp psoriasis. In: Koo JY, Lee CS, Lebwohl M, eds. Mild-to-
moderate psoriasis. 2nd ed. New York: Informa Healthcare; 2009. p. 197-207.
12. Lee RA, Van Voorhees AS. Inverse psoriasis. In: Koo JY, Lee CS, Lebwohl M, eds. Mild-to-moderate psoriasis. 2nd
ed. New York: Informa Healthcare; 2009. p. 209-23.
13. Lauritz B. The management of psoriasis. Aust Fam Physician 1982;11:704-8, 711.
14. Christophers E, Kiene P. Guttate and plaque psoriasis. Dermatol Clin 1995;13:751-6.
15. Prytowsky JH, Cohen PR. Pustular and erythrodermic psoriasis. Dermatol Clin 1995;13:757-70.
16. Wu JJ, Weinstein GD. General guidelines for administration of topical agents in the treatment of mild-to-
moderate psoriasis. In: Koo JY, Lee CS, Lebwohl M, eds. Mild-to-moderate psoriasis. 2nd ed. New York: Informa
Healthcare; 2009. p. 11-21.
17. Katugampola RP, Lewis VJ, Finlay AY. The Dermatology Life Quality Index: assessing the efficacy of biological
therapies for psoriasis. Br J Dermatol 2007;156:945-50.
18. National Institute for Health and Care Excellence (NICE). Psoriasis: Evidence update November 2014.
Manchester: NICE; 2014. Available from: www.nice.org.uk/guidance/cg153/evidence/evidence-update-
188313949.
19. Chren MM, Lasek RJ Quinn LM et al. Skindex, a quality-of-life measure for patients with skin disease: reliability,
validity, and responsiveness. J Invest Dermatol 1996;107:707-13.
20. Cappelleri JC, Bushmakin AG, Harness J et al. Psychometric validation of the physician global assessment
scale for assessing severity of psoriasis disease activity. Qual Life Res 2013;22:2489-99.
Prevention and Treatment of Sun-Induced Skin Damage

Pathophysiology
The skin and its appendages (e.g., sweat glands, sebaceous glands and hair follicles) serve several important
functions. They protect against minor injury, help control body temperature and water loss, prevent invasion by
microorganisms, and prevent radiation damage from sun exposure. The skin is composed of 3 main layers: epidermis
(which includes the stratum corneum), dermis and subcutaneous layer (Figure 1).1
Figure 1: The Skin
Ultraviolet Radiation
Ultraviolet light is divided into 3 categories: ultraviolet-A (UVA; 320–400 nm), ultraviolet-B (UVB; 290–320 nm) and
ultraviolet-C (UVC; 270–290 nm).2
Longwave UVA radiation penetrates the dermis and subcutaneous fat. UVA is a less potent carcinogen than
UVB or UVC, but is a significant contributor to skin cancer risk because more reaches the Earth than other
types of ultraviolet (UV) radiation. UVA is present all day and can penetrate through clouds, windows and
clothing. UVA radiation penetrates deep into the skin. There is a strong indication that UVA is responsible for
phototoxicity, photoaging, immunosuppression, epidermal thickening, reduced skin barrier function and skin
cancers.3 UVA is also responsible for reactions from photosensitizing drugs such as amiodarone, doxycycline,
hydrochlorothiazide, naproxen and voriconazole.4
UVB damages the stratum corneum and epidermal layers. It is the main cause of sunburn and plays a role in
both skin cancer and photoaging.3 Acute exposure increases blood flow to the skin and activates
inflammatory pathways, resulting in reddened skin and sunburn. However, even at doses too low to cause skin
reddening, UVB can cause local and systemic immunosuppression, direct damage to DNA and other skin cell
abnormalities that increase the risk of skin cancer.2 UVB is strongest between 10 a.m. and 4 p.m. and at high
altitudes, and is intensified by wind, humidity, high temperatures and reflective surfaces (e.g., water, sand,
snow, concrete).2
UVC does not reach the surface of the Earth as it is filtered by the surrounding ozone layer.
The UV index is provided by Environment Canada and predicts the strength of the sun's UV rays. Higher UV readings
indicate a higher risk of sunburn as the rays are stronger. UV indexes of 3 or more are reported daily.
Sun-induced Skin Damage
Sun-induced skin damage includes sunburn, photoaging, pigmentary changes, actinic keratosis and skin cancer.
Sunburn is an inflammatory response of the skin to UV radiation. Sunburn is preventable and generally self-
treatable. Refer to Burns, for assessment and treatment of burns.
Photoaging refers to the effects of long-term exposure to the sun and is commonly referred to as “premature skin
aging”.5 The effects can be seen many years before normal age-related changes are noted in non-sun-exposed
areas. The difference between the signs of normal aging and photoaging can readily be seen by comparing non-sun-
exposed areas of the body with skin on the face, arms and hands. Skin changes in photoaging differ from those in
normal skin aging. In photoaged skin, changes in the stratum corneum and epidermal cells result in rough, coarse,
dull-appearing skin with fine and deep wrinkles. In more advanced photoaging, deposition of abnormal elastic fibres,
decreased collagen and pigment changes in the upper dermis result in deeply wrinkled, yellowish skin. Vascular
changes in the dermis can cause telangiectasias and easy bruising. A change in the properties of water-retentive
glycosaminoglycan contributes to the dry, rough, leathery appearance of photoaged skin.6
Pigmentary changes result from chronic exposure to UV radiation. Hypermelanosis is characterized by an increase
in pigmentation, slowly progressing to irregular areas on the skin that range in colour from light to dark brown. It
appears primarily on sun-exposed areas, particularly the face, and is commonly referred to as “age spots”.7
Actinic keratosis is a common sun-induced lesion caused by chronic exposure to sun and is more prevalent in
males and in light-skinned individuals. Onset is typically after the age of 50. It generally appears on the face, back of
the hands, forearms and legs as a firm, scaling lesion with slight erythema. If left untreated, actinic keratosis can
progress to squamous cell carcinoma.8 (See Photo, Actinic Keratosis)
Photo 1: Actinic Keratosis
Nonmelanoma Skin Cancer: Squamous cell carcinoma risk is related to chronic, cumulative lifetime sun exposure;
therefore, people with visibly photoaged skin are at greater risk. Commonly found on the face, ears, neck, forearms,
back of the hands and legs, it initially appears as an abnormal scaling or crusty lesion that may be raised and wart-
like. The lesions may bleed or erode over time, leading to firm tumors.5 Basal cell carcinoma is related to sun
exposure during childhood and adolescence and is commonly found on the face. It appears as small, dome-shaped
lesions that may have a shiny surface (much like a pimple that does not heal) that slowly expand over time and
develop central ulceration.8
Melanoma Skin Cancer: Malignant melanoma appears to be related to intense and intermittent sun exposure in
childhood and adolescence. It is the rarest type of cancer, but is responsible for the majority of skin cancer deaths.
Risk is increased in blond or red-headed individuals who have skin that tans poorly and burns easily, in those with a
large number of moles, with chronic exposure to the sun or in those with a history of sunburns as a child. It appears
as a flat brown or black spot (commonly in a mole or other dark spot) with irregular edges, that can grow larger if
left untreated.8
Goals of Therapy
Prevent acute sun-induced skin damage (sunburn)
Prevent phototoxic reactions from medications
Provide relief of pain resulting from sunburn
Minimize the risk of infection in severe sunburns
Prevent long-term sun-induced skin damage (including photoaging and some types of skin cancer)
Reduce the visible effects of photoaging on the skin
Patient Assessment
If the concern is sun-induced skin damage, determine whether the goal is prevention (selection and use of sunscreens)
or treatment. Figure 2 presents an assessment of patients requesting sun protection.
Prevention of Sun-induced Skin Damage
There are many ways to prevent the acute and chronic effects of sun exposure. Avoiding direct sun exposure from
10 a.m. to 4 p.m. when UVB rays are strongest as well as when the UV Index is high decreases the risk of sunburn.2
A person should seek shade as much as possible while outside. Wearing protective clothing such as long-sleeved
shirts, pants and gloves decreases exposure. Cotton or linen clothing that is tightly woven, loose fitting and
lightweight provides some protection. Clothing that is wet, white or loosely woven provides very little protection
(darker colours give better protection).2 Wide-brimmed hats of tightly woven fabric will protect the face, ears and
parts of the neck from sun exposure, and long-term use will reduce the risk of skin cancers by 40%.2 Sunglasses
should be worn to protect the eyes from sun damage. Children under the age of 6 months should be protected from
the sun at all times by keeping them shaded and completely covered.
Tanning salons should be avoided; the protection provided against environmental UV exposure (such as sunburn on
tropical holidays) is minimal. Tanning bed use increases the risk of basal and squamous cell carcinoma11 as well as
melanoma.12 The World Health Organization (WHO) recommends that no one under the age of 18 use tanning
facilities. If used, time limits should be observed and protective eyewear should be worn at all times during the
session.
Phototoxic reactions are dose-related sunburn-like reactions that occur in all people with sufficient light and drug
exposure. Those taking medications that may cause phototoxic reactions should use extra precautions to prevent
acute and chronic sun damage (see Table 1). Radiation in the UVA range causes most drug-related phototoxic
reactions. In contrast, photoallergic reactions are delayed hypersensitivity reactions after light exposure, and occur
only in a small percentage of individuals. Unlike phototoxic reactions, photoallergic reactions may extend beyond
the area exposed to light.
a,13
Table 1: Medications that May Cause Phototoxic Reactions
Antimicrobials Azole antifungals (itraconazole, voriconazole), ceftazidime, quinolones
(ciprofloxacin, norfloxacin, ofloxacin), sulfonamides, tetracyclines
(doxycycline, tetracycline), trimethoprim
Antineoplastics Dacarbazine, EGF inhibitors (cetuximab, erlotinib, gefitinib, lapatinib,

panitumumab), 5-fluorouracil, paclitaxel, vinblastine
Diuretics Furosemide, hydrochlorothiazide
NSAIDs Diclofenac, ibuprofen, indomethacin, ketoprofen, naproxen, piroxicam,

sulindac, tiaprofenic acid
Psychiatric medications Alprazolam, chlordiazepoxide, chlorpromazine, desipramine,

fluphenazine, imipramine, perphenazine, prochlorperazine,
trifluoperazine
Retinoids, systemic Acitretin, alitretinoin, isotretinoin
Retinoids, topicalb Adapalene, tazarotene, tretinoin

Statins
Others Amiodarone, coal tar derivatives (topical), diltiazem, methoxsalen,

quinidine, quinine, sulfites, tolbutamide, verteporfin
a
Radiation in the UVA range causes most drug-related phototoxic reactions.
b
After continued use due to thinning of the stratum corneum.
Abbreviations: EGF = epidermal growth factor; NSAID = nonsteroidal anti-inflammatory drug
Skin Care Products: Sunscreens.
Sunscreens effectively reduce skin tanning and sunburn. Sunscreen use can also reduce photoaging and
development of actinic keratosis, and promote regression of existing actinic keratosis.2 It is estimated that regular
sunscreen use for the first 20 years could decrease the lifetime risk of skin cancer by about 85%.14 Daily sunscreen
use for 4.5 years decreased the incidence of squamous cell cancer15 and reduced new primary melanomas by 50%
and invasive melanomas by 73%.16 Sunscreens are an adjunct only, and should be used to protect the skin rather
than prolong the time that can be spent in the direct sun. Sunscreens should always be used in conjunction with
protective clothing in order to fully protect exposed skin.17
The Canadian Dermatology Association recommends that sunscreens should:18
have an SPF of at least 30

be nonirritating, noncomedogenic and hypoallergenic
be minimally or nonperfumed
offer broad-spectrum UVA protection.
Sunless tanning products contain chemical tanning agents such as dihydroxyacetone (DHA), a dye that colours the
skin when applied topically to produce an artificial tan. The colour change is temporary, lasting several days, and
must be reapplied every few days to maintain an even colour. Tanning agents have a very low sun protection factor
(SPF) value of 3–4 unless marketed in combination with sunscreen products. Dihydroxyacetone is considered
nontoxic and is regulated as a cosmetic rather than as a drug.19
Sunscreen Labelling
Sunscreens should be used to protect the skin and not to prolong sun exposure. They should be broad spectrum
meaning contain recognized ingredients that protect against both UVA and UVB (see Table 2). Sunscreens
should have an SPF of at least 15 and preferably 30. SPF is defined as the least amount of energy needed to
produce erythema (primarily UVB) with sunscreen, divided by the least amount of energy needed to produce
erythema without sunscreen. Sunscreens with the “broad spectrum” designation and SPF ≥15 may use the
following statement: “If used as directed with other sun protection measures, decreases the risk of skin cancer
and early skin aging caused by the sun”. Sunscreens with an SPF <15 or not designated as “broad spectrum”
must use the following statement: “This product has been shown only to help prevent sunburn, not skin cancer
or early skin aging”.20,21
Water-resistant products may be labelled only as “Water/Sweat Resistant (40 minutes)” or “Water/Sweat
Resistant (80 minutes)”.20,21
Sunscreen Application
Sunscreens are combinations of several different active ingredients and may contain physical blockers as well
as chemical sunscreens (see Table 2). Physical barriers such as titanium dioxide and zinc oxide reflect and
scatter UV radiation while chemical agents absorb UV light. Physical barrier products currently available have
been micronized to be more cosmetically appealing than older products.5
To ensure full effectiveness, sunscreens should be applied uniformly and liberally over the entire area of sun
exposure, including lips, ears and tops of the feet. Sunscreen should be applied 15–30 minutes prior to exposure
with reapplication 15–30 minutes later to maximize protection.2 Sunscreens should also be reapplied after
swimming, sweating or towelling off. It is recommended that 2 mg of sunscreen per cm2 of skin be applied to
the body to ensure that the SPF protection claimed by the manufacturer is reached.8,24,25 An easier way to
measure the appropriate amount of sunscreen is referred to as the “teaspoon rule.” It is recommended that a
person apply 0.5–1 teaspoonful on the face and neck; 1–1.5 teaspoonfuls to arms, shoulders and torso and 2–
2.5 teaspoonfuls to the legs and the tops of the feet.24
Many individuals do not apply enough sunscreen to attain the stated SPF of the product. Ensure that patients are
aware of the proper application methods and that sunscreen should be reapplied after sweating or being in
water. Lip balms should also be used on a regular basis to protect lips from the sun. Sunscreen vehicles also
affect the application of the product. Lotions and creams are the most common vehicles used and are
formulated as oil-in-water or water-in-oil emulsions; inadequate application may occur because the products
may be greasy and less desirable than other formulations. Gels are preferred by patients with oily skin but are
easily removed when swimming or sweating. Products that are in a spray formulation are convenient and easy
to apply. The disadvantage is that sprays are often applied with a thin layer of coverage, areas are missed
completely or the spray is not rubbed in sufficiently for full effectiveness.26
Sunscreen and Vitamin D
Vitamin D synthesis requires UVB exposure. In theory, 90% of the required vitamin D can be produced this way. In
practice, the production of vitamin D is highly variable depending upon which area of skin is exposed to the sun
and for how long, latitude, skin pigmentation, age, and season.27 There has been some concern that the
increased use of sunscreens decreases the synthesis of Vitamin D. The debate continues as to the impact of the
use of sunscreens on the production of vitamin D and the American Academy of Dermatology suggests
supplementation.26
Sunscreen Safety
Limited animal and laboratory studies about the safety of some sunscreen ingredients or additives have
attracted media attention. These have included carcinogenicity of retinyl palmitate, hormone disruption by
oxybenzone and absorption of nanoparticles of zinc and titanium. However, many national dermatology
associations have responded to these concerns with statements reassuring consumers that evidence from use
in humans shows that approved sunscreen ingredients are safe to use and protect against skin cancer.28,29,30
13,22,23
Table 2: Sunscreen Ingredients
Class/
Chemical Name (synonyms) Wavelength Benefits Comments
Anthranilates UVB (weak) Allergic reactions are

meradimate (menthyl anthranilate, UVA rare.
menthyl-2-aminobenzoate) (incomplete
protection,
300–340 nm)
Benzimidazoles UVB Well tolerated Water soluble

ensulizole (2-phnylbenzimidazole- (minimal UVA) Photostable Allergic reactions are
5-sulfonic acid, PBSA, Eusolex 232, rare.
Parsol HS) 290–320 nm
Class/
Benzophenones UVB May advertise as Some skin

dioxybenzone (benzophenone-8) Lower UVA broad-spectrum sensitization, allergic
oxybenzone (benzophenone-3, UVB/UVA protection; reactions.
260–380 nm cover most of UVB
Escalol 567, Eusolex 4360) depending on Must be combined
plus lower-mid UVA with titanium dioxide
sulisobenzone (benzophenone-4, 2- chemical range.
hydroxy-4-methoxybenzone-5- and/or zinc oxide for
sulfonic acid) stability.
Benzotriazoles UVB Characteristics of Allergic reactions are

bisoctrizole (methylene bis- UVA (broad organic and inorganic rare.
benzotriazolyl- spectrum, filters.
tetramethylbutylphenol, Tinosorb maximum
M) absorption 360
nm)
Benzylidene camphor derivatives UVB Photostable Water soluble

enzacamene (4-methylbenzylidene Maximum
camphor, MBC, Eusolex 6300, absorption at
Parsol 5000) 300 nm
terephthalylidene dicamphor UVB Good photostability Easily removed

sulfonic acid (ecamsule, Mexoryl UVA (broad through perspiration
SX) spectrum, or swimming (need
maximum to be combined with
absorption 345 products that do not
nm) wash off).
Allergic reactions are
rare.
Cinnamates UVB Photostabilize Easily removed by

cinoxate (2-ethoxyethyl p- May have some dibenzoylmethanes abrasion, perspiration
methoxycinnamate) UVA (avobenzone). or swimming (need
octinoxate (octyl Octocrylene: Some to be combined with
280–320 nm products that do not
methoxycinnamate, 2- coverage in low UVA
ethylhexylmethoxycinnamate, EMC, range which allows wash off). Require
OMC, Escalol 557, Parsol MCX) products to claim frequent application.
octocrylene (2-ethylhexyl-2-cyano- UVB/UVA protection. Allergic reactions are

3,3-diphenylacrylate, OCR, Eusolex) rare.
Dibenzoylmethanes UVA (broad Better UVA protection 60% decrease in

avobenzone (t-butylmethoxy- spectrum, 320– than benzophenones efficacy after 1 h of
dibenzoylmethane, Eusolex 9020, 400 nm) and Mexoryl SX. exposure to the sun
Parsol 1789) (combined with
Mexoryl to enhance
photostability).
May cause allergic
reactions/contact
dermatitis.
Photo unstable.
Hydroxybenzotriazoles UVB Photostable Allergic reactions are

drometriazole trisiloxane UVA (broad rare.
(silatriazole, Mexoryl XL) spectrum, 320–
360 nm)
Class/
Hydroxyphenyltriazines UVB Included in products

bemotrizinol (anizotriazine, bis- UVA (broad to improve the
ethylhexyloxyphenolmethoxyphenyl spectrum, photostability of
triazine. Tinosorb S) maximum sunscreens
absorption 343 containing
nm) avobenzone.
Para-aminobenzoic Acid (PABA) UVB Resistant to water Can cause skin

esters 260–320 nm and sweating and irritation and
padimate O (octyl dimethyl PABA) adhere well to skin photosensitivity
even after swimming. reactions. Rarely
included in products
due to frequency of
sensitivity issues
(contact dermatitis).
Can stain clothing.
Avoid in those
sensitive to
sulfonamides,
thiazides and
sulfonylureas.
Physical blocks (inorganic UVB, UVA (full Can be used by all Titanium should not
agents) spectrum) ages (infants >6 be used on children
titanium dioxide zinc oxide: months). under 6 months or
zinc oxide 290–400 nm Less risk of applied to open
sensitization than wounds.
titanium
dioxide: 290– chemical sunscreens. May cause or worsen
340 nm Photostable. acne by clogging skin
pores.
Reflect and scatter
UV and visible light.
Clear formulations of
micronized particles
are cosmetically more
appealing.
Salicylates UVB only Skin irritation is rare. Easily removed by

homosalate (homomenthyl (weak) Very stable; included abrasion, perspiration
salicylate, HMS) 260–320 nm in other products to or swimming.
octisalate (octyl salicylate, 2- improve stability and
ethylhexyl salicylate, Escalol 587) augment UVB
triethanolamine salicylate protection.
(trolamine salicylate)
Treatment of Sun-induced Skin Damage
Treatment of sunburns, both minor and severe, includes relieving the discomfort caused by the burn. Application of
cool tap water compresses will relieve some pain associated with minor sunburn. Patients should avoid further
exposure to the sun to prevent further burning, which could lead to an increase in the severity of the sunburn. If
further exposure to the sun cannot be avoided, the individual should wear protective clothing, apply a sunscreen and
limit the amount of time in the sun during peak times (10 a.m. to 4 p.m.).
Analgesic Products: Internal Analgesics and Antipyretics; Skin Care Products: First Aid.
Therapy for Sunburn
Skin protectants such as petrolatum and hydrophilic ointments provide symptomatic relief of minor sunburns
and redness. These products protect the area from irritation caused by friction from clothing and moisturize and
rehydrate the skin. Bath and baby oils have minimal effect and peanut and corn oil are ineffective.31
Analgesics are used short term to relieve the pain and mild inflammation caused by sunburn. They should be
taken either just before or immediately after exposure as inflammation generally occurs within the first 24 hours.
Anti-inflammatory agents such as ibuprofen, naproxen sodium or acetylsalicylic acid (ASA) are recommended.
Acetaminophen can also be used for pain relief if anti-inflammatories cannot be used.31
Topical aloe vera has traditionally been promoted for its wound-healing ability. A systematic review found that
there is inconclusive evidence to determine whether aloe vera gel or dressings improve outcomes in acute
wounds including burns.32 The amount of active ingredient in aloe vera products varies according to growing
conditions, age of the plant, harvesting and extraction methods used.33 Some patients may experience burning
sensation, contact dermatitis or mild itching with topical use.
For information on further therapy, consult the Compendium of Therapeutic Choices:Sunburn.
Therapy for Photoaging
Topical retinoids can improve the appearance of sun-damaged skin. Mechanisms involved are thought to
include: increased synthesis and inhibited degradation of collagen leading to less pronounced wrinkles, initiation
of epidermal proliferation causing increased smoothness of the skin and decreased melanin content, and
enhanced keratinocyte shedding leading to improvement in skin discolouration. They have also been shown to
block skin degradation following sun exposure. Improvement is typically seen after several weeks of treatment.
Continued treatment over 6–12 months results in skin that is smoother and less sallow, has reduced fine and
coarse wrinkles, and is less mottled.34,35,36 Currently in Canada, only tazarotene cream is approved for this
indication; however, in practice other available topical retinoids (tretinoin, adapalene) are also used. Adverse
effects include burning, irritation, redness and dryness which usually subside over time. A titrated approach to
treatment can minimize these reactions.
Commercial skin care products containing retinol have limited efficacy because the skin is able to convert only
small amounts of retinol to retinoic acid. Products containing vitamin A do not contain sufficient concentrations
of retinoids to effectively treat photoaging and are likely added for their moisturizing properties.37
Alpha-hydroxy acids (glycolic acid and lactic acid) are widely available in low concentrations (usually 5–12 %)
in many commercial products marketed for photoaged skin. Although scientific evidence of clinical
effectiveness is limited,38,39 anecdotal evidence is widely accepted. These products may help reduce the
appearance of minor photodamage by reducing fine lines, and improve skin firmness and tone by removing dead
cells from the surface of the skin. Higher concentrations are required for deeper effects and must be
administered under supervision of a dermatologist (see Chemical Peels).
Antioxidants including vitamin C and coenzyme Q10 derivatives are included in many products purported to
improve the signs of photoaging. Other compounds being investigated for their ability to reverse the signs of
photoaging include soy isoflavones, green tea polyphenols, lutein, carotenoids, ginseng and peptides. In some
cases there are (mostly) commercial in vitro studies showing promising results, but uncertainty around their
clinical effectiveness remains because of the lack of independent, published in vivo evidence and questions
about their effectiveness/stability in combination with other compounds and in the low concentrations that are
available without a prescription.40
Chemical peels contain alpha-hydroxy acids, salicylic acid, trichloroacetic acid or phenol. Chemical peels
induce controlled damage to the skin at various skin depths. Regeneration and re-epithelialization of the
epidermis and dermis results in firmer skin with a more even skin tone. Chemical peels can be superficial,
medium or deep depending on the extent of the photodamage. Glycolic acid chemical peels involve
concentrations ranging from 20–70% which are administered in a step-wise fashion over several weeks or
months. Chemical peels improve skin texture, reduce wrinkles and decrease the number of actinic keratoses.5,41
Mottled Hyperpigmentation: Various treatments are used to lighten darkened skin areas that appear with
photoaging, leading to an more even skin tone. Topical treatment with hydroquinone may help to reduce visibility
and degree of mottled pigmentation. Hydroquinone does not affect the upper layer of the skin but interacts with
melanin production in the lower layers of the epidermis. Skin improves over 3 weeks to 3 months. Recurrence is
prevented by limiting sun exposure and using a sunscreen, particularly on areas that have been treated.34 Skin
irritation, redness and allergic or contact dermatitis have been reported. Hydroquinone can occasionally cause
reversible discoloration of the fingernails and has been rarely associated with exogenous ochronosis (persistent
blue-black pigmentation of the skin) particulary in dark-skinned individuals.42 Some countries have banned
hydroquinone due to concerns about carcinogenicity and renal toxicity after oral administration in mice and
rats,43,44 but the relevance to topical use in humans is uncertain as the product has been used seemingly safely
for decades. Other compounds used for skin lightening include topical retinoids (reduce epidermal pigmentation
by an unclear mechanism) and topical corticosteroids (reduce production of melanin). Various combinations of
these ingredients have been used with success when monotherapy has been unsuccessful.
OnabotulinumtoxinA does not reverse photodamage but appears to rejuvenate the skin by relaxing the
underlying musculature. The effects of treatment typically last 3 months.5 Hyaluronic acid is a soft tissue filler
injected into wrinkles to improve the appearance of the skin. Results usually last 6–9 months in areas with more
movement and up to 1 year in areas of limited mobility. Photodynamic therapy (exposure to UV light after use of
a photosensitizer) and laser therapy are also used for the treatment of photoaging.
Figure 3 presents an assessment of patients requesting treatment for nonacute sun-induced skin damage (also
see Table 4).
Table 3 provides a plan for the monitoring of therapy for sun-induced skin damage.
Table 3: Monitoring of Therapy for Sun-induced Skin Damage

Early photodamage Monitor for changes in skin Skin feels softer, Prevention is the most
(fine wrinkles, dry appearance (rough, dry smoother, fine wrinkles effective treatment (continual
skin) skin with surface or deep less apparent. use of sunscreens with SPF
wrinkles). Skin does not show 30 or more).
Monitor regularly for signs signs of pigment Tretinoins, chemical peels
of mottling or pigment change. and antioxidants may reverse
changes (“liver” spots or or improve signs.
“age” spots).
Sunburn Monitor for 24–48 h after Sunburn lessens or Cool compresses to relieve
unprotected sun exposure disappears after 48 h. pain.
for worsening or Pain relief is adequate. Analgesics for pain relief
improvement of burn. (acetaminophen, ibuprofen).
No signs of infection
Monitor pain 24–48 h. after 48 h. Skin protectants such as
Monitor for 7 days for petrolatum to protect and
signs of infection moisturize.
(particularly if blistered). Avoid further exposure.
Signs of infection require
assessment and treatment if
appropriate.
Actinic keratosis Monitor regularly for dry, No signs of actinic Avoid chronic exposure to
scaly lesions on chronically keratosis, e.g., firm sun.
sun-exposed areas scaling lesion with Further investigation required
(particularly age ≥50 y). slight erythema. if changes in the area (rule
Monitor closely for signs of out squamous cell
change (size, shape or carcinoma, basal cell
colour). carcinoma or melanomas).
Wear sunscreens regularly
and cover area to protect
from further sun exposure.
Algorithms
Figure 2: Assessment of Patients Requesting Protection from Sun-induced Skin Damage
a
If sun exposure is unavoidable notwithstanding these measures, a broad-spectrum SPF 30 sunscreen for babies can be
applied to the small exposed areas (e.g., face, back of hands).9 Inorganic (physical) sunscreens containing zinc oxide and/or
titanium dioxide are minimally absorbed and less likely to cause sensitization.10
Abbreviations: SPF = sun protection factor; UVA = ultraviolet-A; UVB = ultraviolet-B
Figure 3: Assessment of Patients Requesting Treatment for Nonacute Sun-induced Skin Damage
Drug Table
Table 4: Topical Therapy for Photoaged Skin
Class Drug Dosage Mechanism Adverse Comments Costa
of Action Effects
Alpha- glycolic acid 5–10% Removes Initially (but Higher $

hydroxy acids Biobase-G, cream/lotion: dead cells decreasing concentrations
Neostrata Apply daily to from surface with time): (20–70%) used in
HQ Gel, BID of skin, burning, superficial
others leading to stinging, chemical peels
less visible redness. under expert
lines and Increases supervision may
wrinkles and sensitivity to provide deeper
a smoother UV light: effects, including
appearance. always use in thickening of the
conjunction epidermis and
with depigmentation.
sunscreen. May cause
hyperpigmentation:
avoid use in dark-
skinned patients.
Alpha- lactic acid 5–12% Removes Mild redness, May cause $

hydroxy acids Dermalac, cream/lotion: dead cells dryness. hyperpigmentation:
others Apply daily to from surface Increases avoid use in dark-
BID of skin, sensitivity to skinned patients.
leading to UV light:
less visible always use in
lines and conjunction
wrinkles and with
a smoother sunscreen.
appearance.
of Action Effects
Depigmenting hydroquinone 2–4%: Apply Decreases Skin irritation, Often combined $

agents Esoterica, thinly BID melanin redness and with glycolic acid
Ultraquin, production, risk of contact and sunscreen.
others leading to dermatitis. Use in conjunction
lighter skin Reversible with sunscreen
tone over 3 discolouration decreases risk or
wk to 3 of the recurrence of dark
months. fingernails. pigment.
Retinoids adapalene 0.1% cream, Decreases Scaling, A minimum of 4 $$$

Differin, 0.3% gel: fine lines, redness, months of
Differin XP Apply QHS improves burning and treatment is
skin texture, dermatitis, required to see any
tone, which often positive results.
elasticity, subsides with Not a Health
mottled continued Canada–approved
pigmentation. use. indication.
Slows May cause
progression increased
of sensitivity to
photoaging. the sun: apply
at bedtime
and use
broad-
spectrum
sunscreen
(SPF ≥15)
during the
day.
Retinoids tazarotene 0.1% cream: Decreases Scaling, A minimum of 4 $$

Tazorac Apply QHS fine lines, redness, months of
Cream improves burning and treatment is
skin texture, dermatitis, required to see any
tone, which often positive results.
elasticity, subsides with
mottled continued
pigmentation. use.
Slows May cause
of sensitivity to
at bedtime
and use
broad-
spectrum
sunscreen
(SPF ≥15)
during the
day.
of Action Effects
Retinoids tretinoin 0.01%, Decreases Scaling, A minimum of 4 $

Retin-A, 0.02%, fine lines, redness, months of
Retin-A 0.05%, 0.1% improves burning and treatment is
Micro, cream: Apply skin texture, dermatitis, required to see any
Stieva-A QHS tone, which often positive results.
elasticity, subsides with Not a Health
mottled continued Canada–approved
pigmentation. use. indication.
Slows May cause
of sensitivity to
at bedtime
and use
broad-
spectrum
sunscreen
(SPF ≥15)
during the
day.
a
Cost of 25 g or 25 mL; includes drug cost only.
Legend: $ <$20 $$ $20–40 $$$ $40–60
Suggested Readings
Antoniou C, Kosmadaki M, Stratigos AJ et al. Sunscreens–what's important to know. J Eur Acad Dermatol Venereol
2008;22:1110-8.
Government of Canada. Sunscreens. Available from: healthycanadians.gc.ca/health-sante/environment-

environnement/sun-soleil/screen-ecrans-eng.php.
Lautenschlager S, Wulf HC, Pittelkow MR. Photoprotection. Lancet 2007;370:528-37.
Poon F, Kang S, Chien AL. Mechanisms and treatments of photoaging. Photodermatol Photoimmunol Photomed
2015;31:65-74.
Ramirez R, Schneider J. Practical guide to sun protection. Surg Clin North Am 2003;83:97-107.
References
1. Bond CA. Skin disorders. In: Koda-Kimble MA, Young LY, eds. Applied therapeutics: the clinical use of drugs.
Vancouver: Applied Therapeutics; 1992. p. 64-1-6.
2. Kullavanijaya P, Lim HW. Photoprotection. J Am Acad Dermatol 2005;52:937-58.
3. Wondrak GT, Jacobson MK, Jacobson EL. Endogenous UVA-photosensitizers: mediators of skin photodamage
and novel targets for skin photoprotection. Photochem Photobiol Sci 2006;5:215-37.
4. Drucker AM, Rosen CF. Drug-induced photosensitivity: culprit drugs, management and prevention. Drug Saf
2011;34:821-37.
5. Rabe JH, Mamelak AJ, McElgunn PJ et al. Photoaging: mechanisms and repair. J Am Acad Dermatol 2006;55:1-
19.
6. Lawrence N. New and emerging treatments for photoaging. Dermatol Clin 2000;18:99-112.
7. Cayce KA, McMichael AJ, Feldman SR. Hyperpigmentation: an overview of the common afflictions. Dermatol
Nurs 2004;16:401-6, 413-6.
8. MacKie RM. Long-term health risk to the skin of ultraviolet radiation. Prog Biophys Mol Biol 2006;92:92-6.
9. Environment and Climate Change Canada. Sun protection for babies. Available from:
www.ec.gc.ca/uv/default.asp?lang=En&n=2B3B8766-1. Accessed April 2016.
Viral Skin Infections: Common and Flat Warts

Pathophysiology
Warts are common viral infections of the skin and mucus membranes caused by any of 150 or more distinct
deoxyribonucleic acid (DNA) viruses in the human papillomavirus (HPV) family. Since warts resemble small
hills on the skin, they are named “verruca” which means “a steep place”. Children and young adults are most
commonly affected. Handlers of meat, poultry and fish have a high incidence of warts. An estimated 12% of
the population is affected at any given time, with the highest prevalence (up to 20%) in school-aged
children.1 Warts are usually spread through broken skin by direct skin-to-skin inoculation of the virus from
an infected person. The degree of exposure to HPV at home and in school contributes to wart development
in elementary school children.2 Time between inoculation and the appearance of a lesion is variable, ranging
from 2–9 months for common warts. Cell-mediated immune responses to the virus are important in host
resistance.3 Immunosuppressed states and organ transplants are predisposing factors for more extensive
or recalcitrant warts.4 Several forms of warts are self-treatable: common warts (hands), flat warts (face)
and plantar warts (foot).3 See Plantar Warts.
Common Warts
Common warts are caused by HPV types 2, 4, 27 and 29. They appear as single or grouped
hyperkeratotic papulonodules most often seen on the knees, fingers, hands and around the nails. They
can occur anywhere on the skin. The lesions typically are small, hard, raised growths with a rough
surface that looks like cauliflower. Spontaneous remission occurs in about two-thirds of affected
patients within 2 years. Recurrence is common.5 See photo, Common Warts.
Photo 1: Common Warts
Flat Warts
Flat warts (also called plane warts) are caused by HPV types 3, 10, 28 and 29 and frequently present as
several flesh-coloured, small papules with a smooth surface, affecting the face or neck. The skin and
dorsa of hands may also be involved. They may arise after scratching or trauma and appear in a linear
arrangement.3
Goals of Therapy
Remove the virus-containing wart with minimal destruction of normal tissue
Prevent spread of the wart
Patient Assessment
A description and differential diagnosis of warts can be found in Table 1. Nongenital warts may cause pain
and may bleed if irritated; otherwise they produce no symptoms and are harmless.
3,6,7,8
Table 1: Characteristics and Differential Diagnosis of Common and Flat Warts
Condition Distribution Lesion Differential Diagnosis
Common Hands, Flesh-toned or grey- Callus: Has skin lines.

warts surrounding brown dome-shaped Seborrheic keratosis: Greasy, pigmented
or beneath papule, studded with (dirty yellow to black colour) appearance,
the nails, or black dots occurring affects middle-aged and elderly persons.
sites of singly or in groups
trauma Molluscum contagiosum: Small, flesh-
coloured, firm, domed papule with a central
pore indentation. A cheesy white material
can be expressed. It affects primarily
children and sexually active young adults.
Comedone (whitehead): Contents can be
expressed. Occurs in the presence of other
acne lesions, e.g., pustules (pimples).
Skin tags: Flesh-coloured papules that lack
the roughness of warts.
Squamous cell carcinoma: Asymptomatic
skin-coloured to reddish-brown firm tumor
on damaged skin. Usually there is a central
ulceration. It occurs in sun-exposed areas
and appears later in life.
Flat Face, backs Skin-coloured or light Epidermal nevi (linear birth marks present
warts of hands, brown, smooth, flat or since birth).
(plane shins slightly elevated Lichen planus: Lesions resemble flat warts
warts) papules occurring in but may be symmetrical and accompanied
multiples by lacy oral lesions.
Patients presenting with warts on the face or genitals and those with recalcitrant or widespread lesions
require assessment by an appropriate healthcare practitioner. Patients with conditions associated with
neuropathies, such as diabetes or circulatory disorders, should not self-medicate with caustic substances
because they are unable to judge the effects of the therapy and are more likely to have poor healing.5,6
Based on the natural course of warts, one-half of primary school children with warts will have resolution 1
year later. Resolution rates are higher in young children and those with non-Caucasian skin types,
independent of the number and/or size of warts. Consider discussing a wait-and-see approach with the
patient and/or family.9 Warts clear more slowly in adults, often persisting for 5–10 years.4
Patients should avoid scratching or biting the wart. This will prevent the development of pain or bleeding
and will reduce the spread of the virus. Patients should not share personal items such as towels that have
been in contact with the wart. Watchful waiting in children is appropriate since two-thirds of untreated warts
will disappear within 2 years.5 However, warts can enlarge and multiply if untreated.6
A small number of trials have examined the use of duct tape to impede viral survival by creating an
occlusive environment. In one study using silver-coloured duct tape applied in cycles of 6 days on, 1 night
off, with soaking and debriding of the wart, an 85% resolution rate was reported.10 Other more rigorous trials
using clear duct tape with acrylic-based adhesive rather than rubber-based adhesive found no benefit.11,12 It
is not clear what role, if any, colour or adhesive type plays in the effectiveness of duct tape. Since there is no
clear evidence of effectiveness and adverse effects such as redness, itching, eczema and bleeding have
been reported, the use of duct tape remains controversial.4,11,13
Curretage and dessication (surgical removal) may be useful for isolated lesions. Local application of
anesthetic by injection or topically is required to ease the pain of the procedure. Atrophic or hypertrophic
scarring may result and recurrence rates can be as high as 30%.14,15,16
Ailments—Foot Care Products: Corns, Calluses and Warts.
Topical therapy is used to remove the virus-containing wart with minimal destruction of normal tissue. The
type of therapy depends on the location, degree of symptoms and the patient's immune status and level of
cooperation. Scarring can occur with more destructive therapies. Therapy may take several weeks or
months.
Evidence supports the use of salicylic acid or cryotherapy for the local treatment of common and flat
warts.17,18,19 Recalcitrant warts (those not responding to 3 months of therapy with salicylic acid or
cryotherapy) often require cryotherapy every 10–14 days combined with salicylic acid or curettage and
electrodessication.4 Up to one-third of nongenital warts become recalcitrant.20
Salicylic Acid
Common and flat warts can be self-treated topically with salicylic acid, which has produced a cure rate
of 52% vs. 23% with placebo.19 Salicylic acid is an effective keratolytic that causes a slow destruction of
the virus-infected epidermis. In addition, an immune response is stimulated by the resulting mild
irritation of the epidermis.4 Salicylic acid is commercially available in a variety of strengths and dosage
forms that may be combined with lactic acid. Strengths of about 17% in liquid (collodion) form are useful
for common warts and multiple warts, whereas strengths of 20–40% as plasters are preferred for thicker
skin areas such as the plantar surface (Table 4).1 Salicylic acid is suitable for use on any cutaneous site
except the face. Instructions for use can be found in Warts—What You Need to Know.
Cryotherapy
A dimethyl-ether/propane mixture is available for home cryotherapy but does not appear to be effective
in achieving the low temperatures necessary for cellular necrosis.4,22 Physician-administered
cryotherapy with liquid nitrogen every 2 weeks can produce a cure rate of 49% after 13 weeks.23
Melamine foam sponge applicators rather than cotton swab applicators may be the optimal method of
application of liquid nitrogen in this setting.24 Freezing temperatures to −196°C cause cell necrosis and
may induce local inflammation where an effective cell-mediated response clears the virus. Cryotherapy
has comparable efficacy to topical salicylic acid but causes more adverse effects including pain,
blistering, scarring, skin irritation, changes in skin pigmentation and crusting.13,17 Caution is necessary
when cryotherapy is applied near cutaneous nerves, tendons and nail apparatus or in patients with
impaired circulation.4
Other Treatments
Because recommended wart management (salicylic acid, cryotherapy) is not consistently effective and
is dependent on patient adherence over long treatment courses, many other treatment options have
been attempted. Evidence of benefit and safety of these approaches is less rigorous than for salicylic
acid and cryotherapy, and they are considered second- or third-line options. The British Association of
Dermatologists guidelines for the management of cutaneous warts has divided these approaches into 4
categories based on their mechanism of action: destructive (salicylic acid and cryotherapy fall into this
category), virucidal, antimitotic and immunologic. These guidelines also provide information on the
quality of available evidence and strength of recommendation.4 Selected therapies from each category
are discussed briefly below.
Destructive Therapy
Lasers produce a controlled thermal destruction of the warts. Unlike CO2 lasers which cause generalized
tissue destruction, pulsed dye lasers and KTP (potassium titanyl phosphate) lasers are selectively
absorbed by hemoglobin in the dermal blood vessels and destroy only the wart vessel vasculature with
additional thermal injury to the HPV virus. Treatment is painless (no local anesthesia required) and no
burning tissue smell is produced. Cure rates up to 89% have been reported.25,26
Photodynamic therapy involves applying a photosensitizer, 5-aminolevulinic acid (ALA) 20%, to the wart
and leaving it on for 3–8 hours followed by exposing the lesion to visible-light irradiation. This induces
photooxidation in abnormal cells. Keratolytics and paring before phototherapy are recommended.
Burning, itching and occasionally severe pain may occur. Cure rates of 56–75% have been reported.27
Cantharidin (0.7%) is a blistering agent produced by beetles that is used in recalcitrant cases with
multiple lesions or in young children. Application in the office is painless but pain and blisters occur up
to 48 hours after application. Repeated applications at intervals of 1–3 weeks are occasionally needed.
Healing without scars occurs in 5–10 days. Reported cure rates are as high as 80% in common, plantar
and periungal warts. Cantharidin is highly toxic if ingested.28,29
Virucidal Therapy
Glutaraldehyde 10% paint applied daily after paring for 3 months produced cure rates of 80% for
periungual and 60% for palmar warts in a small study of young children.30 Deep necrosis can occur upon
repeated application or with higher concentrations.31
Formaldehyde 3–4% solution as a 15- to 20-minute soak daily for 8 weeks (along with paring) produced
a cure rate of 80% for plantar warts in children in one study. Allergic reactions may occur.32
Antimitotic/Antiproliferative Therapy
Bleomycin sulphate (0.1–1 U/mL) intralesional injection is a chemotherapeutic agent that inhibits DNA
synthesis in cells and viruses. It may be used for recalcitrant warts by injecting directly into the wart over
1–3 treatments. Local anaesthesia is necessary since this is painful during and up to 2 days after
treatment. Bleomycin treatment can result in significant systemic drug exposure and should not be used
in children, pregnant women, immunosuppressed patients or those with vascular disease. Cure rates
range from 65–85%.33,34
Podophyllotoxin 0.5% solution is the active ingredient of podophyllin, an antimitotic agent. This solution
can be applied at home once or twice daily 3–4 days per week for up to 4–6 weeks. Pain, burning,
erosions, pruritis and bleeding may occur. If applied to large areas (>10 cm2) or in high concentrations,
systemic absorption may result in neurotoxic effects, limiting use. It has been a standard treatment for
anogential warts, with limited trial data in cutaneous warts. Cure rates using 25% podophyllin in paraffin
for plantar warts were 67%. It is contraindicated in pregnancy.35,36
The topical retinoid tretinoin (0.025–0.1% cream) disrupts epidermal proliferation and differentiation to
reduce wart volume. Applied once or twice daily for 6–12 weeks, it causes skin irritation and dryness
that may contribute to an inflammatory reaction to produce an immunomodulatory effect on the virus.
Studies suggest a cure rate of 85% in children with flat warts37 and 29% in organ transplant recipients.38
There is some evidence of efficacy for oral retinoids. Studies have reported cure rates of 100%39 and
73%40 for treatment of recalcitrant facial warts with isotretinoin. Etretinate produced clearance of 80%
of all warts in a study in children41 and acitretin reduced the bulk of lesions but had a high recurrence
rate in another study.42
5-Fluorouracil 5% cream blocks RNA and DNA synthesis and damages dividing basal layer cells. It can
be applied under occlusion to common warts and flat warts affecting the hands and feet, once daily for
4–12 weeks. Inflammation with occasional erosions and hyper- or hypopigmentation can occur. Local
sun protection is required to prevent an exaggerated response. Cure rates of 60% have been
reported.4,43,44,45,46
Immunotherapy
Contact immunotherapy involving topical application of contact allergens including squaric acid
dibutylester (SABDE), dinitrochlorobenzene (DNCB), or diphenylcyclopropenone (DPCP) has shown
efficacy in recalcitrant cases. DNCB has mutagenic potential and therefore is rarely used.29 Contact
immunotherapy begins with high concentrations applied to a small area of the skin to induce
sensitization. This local, delayed (type IV) hypersensitivity reaction triggers the local immune response
to the virus. Two weeks later, lower concentrations that are titrated are applied twice weekly for 10
weeks. Erythema, edema, pruritis, burning, pigment changes and desquamation may occur. Treatment
should be stopped if diffuse eczema or urticaria develop. Cure rates of up to 86% have been reported.
Proper storage is important; DPCP should not be exposed to light and SABDE must be
refrigerated.47,48,49
Intralesional immunotherapy uses antigens such as Candida, mumps, Trichophyton or tuberculin to

stimulate host cell-mediated immunity. This may be used as a nonscarring method in patients with
multiple recalcitrant lesions or facial lesions. Resolution of multiple warts may be achieved by injecting
only 1 wart, due to the general immune-stimulating effect.4,50 Reported cure rates range from 47–
87%.50,51 Due to limited evidence of safety and efficacy, this therapy is currently only recommended to
be undertaken by experienced dermatologists.4
Imiquimod 5% cream is a topical immunomodulator that enhances cell-mediated immunity. It is a

painless, nonscarring option for treatment of recalcitrant or facial lesions. The cream can be applied
overnight 3 times weekly or up to twice daily, with improvement noted within weeks to months. Duration
of treatment can be as long as 16 weeks. Local pain, pruritus and irritation are usually mild. Imiquimod is
used in the treatment of genital warts, but efficacy in the treatment of cutaneous warts has not been
established. Some small open-label studies have suggested it may be effective (estimated average cure
rate of 44%). Dosing, frequency of application and how to optimally combine imiquimod with other
modalities are all unanswered questions.20,52,53,54
Cimetidine, an oral H2 receptor antagonist, has been used in the treatment of warts. The proposed
mechanism of action is increasing cell-mediated immunity by blocking T-suppressor cells on H2
receptors. A dose of 30–50 mg/kg/day in 4 divided doses for up to 3 months was effective in open label
studies,55,56,57 but ineffective in small randomized controlled trials.58,59,60
A dermatologist referral is necessary if there are symptomatic, recalcitrant warts, multiple warts in
immunocompromised patients, facial lesions unresponsive to topical therapy, or in cases where the
diagnosis is uncertain.61
A summary of treatment recommendations for common and flat warts can be found in Table 2.
4,21,62,63
Table 2: Treatment Recommendations for Common and Flat Warts
Clinical Situation First-line Second-line Third-line Comments
Therapy Therapy Therapy
Common warts, Salicylic acid Cryotherapy Bleomycin, Other treatments
adults 17–40% with Q2–3 wk contact with low-level
occlusion until cleared immunotherapy, evidence:
following (maximum 5-FU, pulsed dye cantharidin,
paring until of 6 laser imiquimod,
cleared (up treatments) podophyllin,
to 3–4 glutaraldehyde,
months) formaldehyde,
photodynamic
therapy.
Common warts, Salicylic acid Gentle Formaldehyde Warts are short-

children 17–40% with cryotherapy solution, lived with clearing
occlusion (milder glutaraldehyde, in 1–2 y. Painful
until cleared freeze) Q2–3 pulsed dye laser, treatments are not
(up to 3–4 wk until systemic well tolerated.
months) cleared retinoids, topical
(maximum immunotherapy
of 6
treatments)
Flat/plane warts Salicylic acid Gentle Topical Caution with

2–10% cryotherapy retinoids, destructive/caustic
without (milder cantharidin, 5- agents as they may
occlusion. freeze) Q2–3 FU, cause scarring at
Cautious use wk until formaldehyde, sites involving
of 12–17% cleared glutaraldehyde, hands and face.
paints. Treat (maximum imiquimod,
until cleared of 6 photodynamic
(up to 3–4 treatments) therapy, topical
months) immunotherapy
Common or flat Salicylic acid Cautious use Imiquimod, Treatment helps to

warts, 2–10% of contact reduce the size of
immunosuppressed without destructive immunotherapy, warts and any
patients occlusion. methods to pulsed dye laser, associated
Treat until avoid intralesional functional or
satisfactory damage to bleomycin, cosmetic problems.
improvement surrounding surgery, topical Clinical cure is
(up to 3–4 skin retinoid, difficult to attain.
months). See systemic
Comments retinoid
Table 3 presents a monitoring framework for patients with warts.
Table 3: Monitoring of Therapy for Warts

Symptoms Monitoring Desired Outcome Actions
Wart size Patient: Daily, Reduction in the size Review application technique
(treatment with watching for dead of wart within 2–3 wk. and evaluate dosage form if
salicylic acid) skin and reduction Disappearance of wart no improvement in 2–3 wk.
in the size of the within 4 or more wk. Patient requires further
wart Return of normal assessment and/or treatment
Healthcare healthy skin if there is no improvement in
practitioner: Review the wart after 12 wk of
response in 2–3 wk treatment.
Wart colour or Patient: Daily, Disappearance of Patient requires further

shape watching for any wart/lesion assessment and/or treatment
suggesting it unexpected if there is any unusual change
may not be a dramatic change in in colour or shape of the
wart colour or shape lesion. Need to rule out
Healthcare cancers.
practitioner: Next
visit
Bleeding after Patient: Daily Absence of bleeding Patient requires further

minimal Healthcare assessment and/or treatment
trauma practitioner: Next if there is any unexplained
visit bleeding. Need to rule out
cancers.
Signs of Patient: Daily Absence of infection Patient requires further

infection such Healthcare assessment and/or treatment
as redness, practitioner: Next if signs are suggestive of a
pain and pus visit secondarily infected lesion.
Warts that are Patient: Daily Absence of enlarging Patient requires further
growing or new warts assessment.
quickly
Allergy Patient: Daily while No allergy Stop therapy. Patient requires

on therapy further assessment and/or
Healthcare treament.
practitioner:
Next visit
Irritation Patient: Daily while Minimal irritation that Stop therapy if no

caused by on therapy subsides with improvement after reinforcing
topical agents Healthcare continued use method of application. Patient
practitioner: Next requires further assessment
visit and/or treament.
Drug Table
Table 4: Salicylic Acid Treatment for Common and Flat Wartsa
Class Drug Dosage Adverse Comments Cost
Effects
Keratolytic salicylic Use 40% for thick- Painless Useful for $8
acid skinned areas application. common
Compound and 17% for thin Stop and flat
W, Soluver, warts or thin- treatment for warts in
others skinned areas a few days if adults and
Assess response treated area children.
after 2–3 wk becomes Cure rate
painful and 52%.17
Apply for up to excessively Best
several months. irritated. supportive
Continue
evidence of
treatment for 1–2
wk after clinical efficacy.17,21
removal of wart Lactic acid
to ensure 17%
complete combination
elimination of is effective.5
virus
Suggested Readings
Lynch MD, Cliffe J, Morris-Jones R. Management of cutaneous viral warts. BMJ 2014;348:g3339.
Mulhem E, Pinelis S. Treatment of nongenital cutaneous warts. Am Fam Physician 2011;84:288-93.
References
1. Kyriakis K, Pagana G, Michailides C et al. Lifetime prevalence fluctuations of common and plane viral
warts. J Eur Acad Dermatol Venereol 2007;21:260-2.
2. Bruggink SC, Eekhof JA, Egberts PF et al. Warts transmitted in families and schools: a prospective
cohort. Pediatrics 2013;131:928-34.
3. Androphy EJ, Lowy DR. Warts. In: Goldsmith LA et al. Fitzpatrick's dermatology in general medicine.
8th ed. New York: McGraw-Hill Professional; 2012.
4. Sterling JC, Gibbs S, Haque Hussain SS et al. British Association of Dermatologists' guidelines for
the management of cutaneous warts 2014. Br J Dermatol 2014;171:696-712.
5. Goldstein BG, Goldstein AO. Cutaneous warts. Available from: www.uptodate.com. Subscription
required.
6. Goldstein BG, Goldstein AO. Practical dermatology. 2nd ed. St. Louis: Mosby; 1997. p. 71-7.
7. Hooper BJ, Goldman MP. Primary dermatologic care. St. Louis: Mosby; 1999.
8. Lookingbill DP, Marks JG. Principles of dermatology. 3rd ed. Philadelphia: W.B. Saunders; 2000.
9. Bruggink SC, Eekhof JA, Egberts PF et al. Natural course of cutaneous warts among primary school
children: a prospective cohort study. Ann Fam Med 2013;11:437-41.
10. Focht DR, Spicer C, Fairchok MP. The efficacy of duct tape vs cryotherapy in the treatment of verruca
vulgaris (the common wart). Arch Pediatr Adolesc Med 2002;156:971-4.
11. de Haen M, Spigt MG, van Uden CJ et al. Efficacy of duct tape vs placebo in the treatment of verruca
vulgaris (warts) in primary school children. Arch Pediatr Adolesc Med 2006;160:1121-5.
12. Wenner R, Askari SK, Cham PM et al. Duct tape for the treatment of common warts in adults: a
double-blind randomized controlled trial. Arch Dermatol 2007;143:309-13.
13. Craw L, Wingert A, Lara-Corrales I. Are salicylic acid formulations, liquid nitrogen or duct tape more
effective than placebo for the treatment of warts in paediatric patients who present to ambulatory
care clinics? Paediatr Child Health 2014;19:126-7.
14. Baruch K. Blunt dissection for the treatment of plantar verrucae. Cutis 1990;46:145-7, 151-2.
43. Hursthouse MW. A controlled trial on the use of topical 5-fluorouracil on viral warts. Br J Dermatol
1975;92:93-6.
44. Iscimen A, Aydemir EH, Goksugur N et al. Intralesional 5-fluorouracil, lidocaine and epinephrine
mixture for the treatment of verrucae: a prospective placebo-controlled,single-blind randomized
study. J Eur Acad Dermatol Venereol 2004;18:455-8.
45. Gibbs S, Harvey I, Sterling J et al. Local treatments for cutaneous warts: systematic review. BMJ
2002;325:461.
46. Gibbs S, Harvey I, Sterling JC et al. Local treatments for cutaneous warts. Cochrane Database Syst
Rev 2003;3:CD001781.
47. Micali G, Nasca MR, Tedeschi A et al. Use of squaric acid dibutylester (SADBE) for cutaneous warts
in children. Pediatr Dermatol 2000;17:315-8.
48. Buckley DA, Keane FM, Munn SE et al. Recalcitrant viral warts treated by diphencyprone
immunotherapy. Br J Dermatol 1999;141:292-6.
49. Higgins E, du Vivier A. Topical immunotherapy: unapproved uses, dosages, or indications. Clin
Dermatol 2002;20:515-21.
50. Horn TD, Johnson SM, Helm RM et al. Intralesional immunotherapy of warts with mumps, Candida,
and Trichophyton skin test antigens: a single-blinded, randomized and controlled trial. Arch Dermatol
2005;141:589-94.
51. Amirnia M, Khodaeiani E, Masoudnia S et al. Intralesional immunotherapy with tuberculin purified
protein derivative (PPD) in recalcitrant wart: a randomized, placebo-controlled, double-blind clinical
trial including an extra group of candidates for cryotherapy. J Dermatol Treat 2016;27:173-8.
52. Grussendorf-Conen EI, Jacobs S, Rubben A et al. Topical 5% imiquimod long-term treatment of
cutaneous warts resistant to standard therapy modalities. Dermatology 2002;205:139-45.
53. Hengge UR, Esser S, Schultewolter T et al. Self-administered topical 5% imiquimod for the treatment
of common warts and molluscum contagiosum. Br J Dermatol 2000;143:1026-31.
54. Ahn CS, Huang WW. Imiquimod in the treatment of cutaneous warts: an evidence-based review. Am
J Clin Dermatol 2014;15:387-99.
55. Mitsuishi T, Iida K, Kawana S. Cimetidine treatment for viral warts enhances IL-2 and IFN-gamma
expression but not IL-18 expression in lesional skin. Eur J Dermatol 2003;13:445-8.
56. Glass AT, Solomon BA. Cimetidine therapy for recalcitrant warts in adults. Arch Dermatol
1996;132:680-2.
57. Orlow SJ, Paller A. Cimetidine therapy for multiple viral warts in children. J Am Acad Dermatol
1993;28:794-6.
58. Rogers CJ, Gibney MD, Siegfried EC et al. Cimetidine therapy for recalcitrant warts in adults: is it any
better than placebo? J Am Acad Dermatol 1999;41:123-7.
59. Yilmaz E, Alpsoy E, Basaran E. Cimetidine therapy for warts: a placebo-controlled, double-blind study.
J Am Acad Dermatol 1996;34:1005-7.
60. Karabulut AA, Sahin S, Eksioglu M. Is cimetidine effective for nongenital warts: a double-blind,
placebo-controlled study. Arch Dermatol 1997;133:533-4.
61. Lynch MD, Cliffe J, Morris-Jones R. Management of cutaneous viral warts. BMJ 2014;348:g3339.
62. Boull C, Groth D. Update: treatment of cutaneous viral warts in children. Pediatr Dermatol
2011;28:217-29.
63. Lipke MM. An armamentarium of wart treatments. Clin Med Res 2006;4:273-93.

Warts
Warts—What You Need to Know
What are warts?
Warts are small, round, hard bumps on the skin that have a rough surface (like a cauliflower). They may be
white, pink or brown and they may have little black dots inside.
Warts are most often found on fingers, hands and the bottom of the feet. They can grow on any part of the body.
Warts usually do not cause pain except when they are on the bottom of the feet.
What causes warts?
Warts are caused by a virus called the human papilloma virus (HPV). This virus can be spread from person to
person by touching the wart. Some people get warts easily while others never do. It is not known why this
happens.
How are warts treated?
Most warts go away without any treatment but it can take a long time for a wart to disappear.
Using a wart treatment is a good idea if:
the wart is painful
it bleeds if it is bumped or rubbed by clothing
it makes you feel embarrassed
you want to prevent warts from spreading to other areas of the body or to other people
Wart treatments kill the skin that contains the virus. Ask your health-care provider for advice about the best wart
treatment for you.
Tips for Using a Wart Treatment
Follow these steps for treating warts:
Soak the wart in warm water for about 10 minutes, then dry the skin lightly.
Apply petroleum jelly (Vaseline) to the normal skin around the wart for protection.
Carefully apply a wart treatment solution (salicylic acid) directly to the wart. You may need to use a toothpick to
apply some solutions. Let the liquid dry for 5 minutes.
Cover the wart with thick, adhesive, medical tape. This keeps the skin moist so the medicine can get into the
wart and work better.
After 24 hours, remove the tape. The top of the wart should have turned grey, which means the treatment
solution has started to destroy the wart. Remove the grey, dead skin by filing it away with an emery board or
pumice. You can get these at any grocery store or drugstore.
Always wash your hands after touching the wart.
Repeat the treatment steps once a day until the wart is gone. It may take several weeks or even months.
If the wart becomes sore, stop the treatment for a few days.
When should you visit your health-care provider?
See your health-care provider if you have warts on your face, genitals (private parts) or around your fingernails.
Don’t use wart treatments in these areas.
See your health-care provider if you still have warts after 8 weeks of home treatment.
What treatments will your health-care provider suggest?
Your health-care provider may suggest any of the following treatments:

a chemical solution that is stronger than home treatments
liquid nitrogen to freeze the wart
burning the wart off with electricity
cutting the wart out or removing it with a laser
The wart may fall off within a few days. You may need more than 1 treatment.
Some of these treatments may be painful or leave a scar.
Will the warts come back?
Treatment does not work every time. The virus may still be in your skin even if it looks like the wart is gone.
If you get more warts, treat them in the same way as before. Be very careful to follow the directions exactly.
How can you prevent the spread of the virus that causes warts?
Do not scratch, bite or chew the warts.

Avoid sharing towels.
Do not share nail files or pumice stones used to pare down the wart.
Cover warts with waterproof plastic tape when using public swimming pools or public showers.
Avoid shaving areas where warts are present.
Viral Skin Rashes
Sandra Knowles, BScPhm

Introduction
Viral infections are frequently associated with the development of exanthems, especially in the pediatric population. These exanthems are
generally nonspecific and often lack characteristic features. Many of the viral exanthems are associated with low-grade fever, myalgias,
headache, rhinorrhea, or gastrointestinal symptoms. This chapter addresses the following topics: rubeola, rubella, erythema infectiosum
(parovirus infection/fifth disease), roseola infantum (sixth disease), Gianotti-Crosti syndrome, hand, foot and mouth disease, varicella
(chickenpox) and herpes zoster (shingles). It should be noted that many other viral eruptions (e.g., herpes simplex, eruption associated with
respiratory and enteric viruses) are not discussed.
Pathophysiology
Characteristics of selected viral skin rashes can be found in Table 1.
Rubeola (Measles)
Measles vaccination resulted in a 74% drop in measles-associated deaths between 2000 and 2012 worldwide. However, there were still 139
300 fatalities in 2010, mostly in low-income countries.1 Measles virus (paramyxovirus) is spread primarily via respiratory droplets. Koplik
spots, which are small gray-blue specks on an erythematous base, appear in the prodromal period. These are found on the buccal mucosa
during the prodrome but disappear within 48 hours after the onset of rash. They are generally diagnostic for measles although they may be
associated with the human parvovirus B19 (erythema infectiosum). Two to 3 days after Koplik spots appear, a purplish red, maculopapular
eruption appears on the scalp, face and neck that spreads downwards. Complications of measles most often include otitis media and rarely
bronchopneumonia, encephalitis, myocarditis and pericarditis.2
Rubella (German Measles)
Although the prodrome and skin eruption are milder than in typical measles, rubella has devastating effects on the developing fetus if
contracted during the first trimester of pregnancy. The most common features of congenital rubella syndrome are sensorineural deafness,
cataracts, congenital heart disease and CNS abnormalities.3 The rubella virus (RNA togavirus) is spread by respiratory droplets. Although in
March 2005 the Center for Disease Control in the United States announced the elimination of endemic rubella and congenital rubella
syndrome in the United States,4 more than 450 000 people contract rubella each year, most of them children in third world countries.5
Erythema Infectiosum (Parovirus Infection/Fifth Disease)
Erythema infectiosum is a childhood exanthem caused by human parvovirus B19 and thought to be spread by respiratory droplet secretions.
It is most common between 4 and 10 years of age. Over 50% of infections are asymptomatic. The eruption occurs in 3 stages: sudden onset
of macular erythema on the face giving a “slapped cheek” appearance; after 1 day, erythematous macular eruption that can last up to 7 days
occurs on the extensor extremities; a reticulated or lacy erythema appears on the extensor extremities that can last up to 3 weeks. The third
stage can recur secondary to friction and sun exposure.5 See photos, Erythema Infectiosum (Parovirus/Fifth Disease). Associated findings
include arthralgia or arthritis in up to 10% of patients, typically involving the small joints of the hands, wrists, knees or ankles and is generally
self-limiting. It is more common in adults, especially women. Fetal infection with parvovirus B19 can lead to anemia with subsequent fetal
hydrops, spontaneous miscarriage and stillbirth. The second trimester, especially between 20 and 28 weeks, is the period of highest risk.3
Photo 1: Erythema Infectiosum (Parovirus/Fifth Disease)
Dr. H.C. Robinson/Science Photo Library

Roseola Infantum (Sixth Disease)
Roseola infantum is a skin rash caused by human herpesvirus 6 (HHV-6) or 7 (HHV-7). The mode of transmission of roseola is unknown.
After an incubation period of 5–15 days, children present with a high fever without an associated illness that lasts approximately 3–5 days.
Febrile convulsions occur in approximately 10% of patients. Rapid defervescence is followed by the onset of a rash which begins on the chest
and generalizes into a pink, maculopapular eruption that lasts 24–48 hours. Most infections occur between 6 months and 3 years of age,
with a peak at 6–7 months.5,6
Gianotti-Crosti Syndrome (Papular Acrodermatitis of Childhood)
The skin eruption of Gianotti-Crosti syndrome is characterized by erythematous, flat-topped papules symmetrically distributed on the face,
buttocks and extremities of children. The trunk is usually spared and the lesions are most commonly nonpruritic. The eruption is self-limiting,
with spontaneous resolution in 3 weeks. Associated features may include lymphadenopathy, hepatomegaly and occasionally splenomegaly.
The eruption is associated with a variety of infectious agents including Epstein-Barr virus, cytomegalovirus and hepatitis B. As well, various
immunizations such as influenza, diphtheria and measles have been associated with Gianotti-Crosti syndrome.7See photos, Gianotti-Crosti
Syndrome.
Photo 2: Gianotti-Crosti Syndrome
DermNet New Zealand
DermNet New Zealand
Hand, Foot and Mouth Disease
The incubation period of hand, foot and mouth disease is 4–6 days with a high rate of contagion. Following an absent or mild prodrome,
lesions appear in the oral mucosa and affect the palms and soles. Characteristic grey-white vesiculopustules are often asymptomatic,
although oral lesions may be painful. Hand, foot and mouth disease is caused by enteroviruses, mostly coxsackie A16. The virus is spread by
direct contact with nose and throat discharges and feces of infected people.8,9 See photo, Hand, Foot and Mouth Disease.
Photo 3: Hand, Foot and Mouth Disease

Varicella (Chickenpox)
Chickenpox is a highly infectious disease caused by the varicella zoster virus (VZV); over 90% of unvaccinated people become infected if
exposed.10 It is transmitted via inhalation of respiratory secretions or contact with skin lesions. Varicella lesions are intensely pruritic and
appear as scattered eruptions which vesiculate, rupture and then crust. The vesicles are often described as looking like “drops of water”.8
Secondary bacterial infection of the lesions and otitis media are the most common complications of varicella, occurring in 5–10% of children.
Healthy children rarely develop serious complications such as pneumonitis, encephalitis, cerebellar ataxis and Reye's syndrome.
Complications are more common and severe in adults or immunocompromised individuals (adults or children). Maternal varicella infection in
pregnancy can lead to complications ranging from asymptomatic latency to severe congenital defects.11 The incidence of embryopathy and
fetopathy after maternal varicella infection in the first 20 weeks of pregnancy is estimated to be 2%.12 In addition, perinatal mortality is high:
nearly 30% of infants with clinical lesions die during the first month of life.13 See photo, Chickenpox (Varicella).
Photo 4: Chickenpox (Varicella)
iStockphoto
Herpes Zoster (Shingles)
Herpes zoster is caused by reactivation of the varicella zoster virus that has remained latent in the sensory ganglia after a previous primary
infection with chickenpox. Herpes zoster is primarily a disease of elderly people but it can occur across all age groups, especially in
immunocompromised individuals. The cause of reactivation is unknown, although physical trauma, ultraviolet light or stress at a time when
the host's immune system is suppressed may play a role.14 Approximately 15% of those who have had the primary varicella infection develop
herpes zoster. The dermatomal distribution of herpes zoster can vary although the thoracic area is involved in more than half of cases. Only
1–8% of patients develop recurrences. Although patients with herpes zoster (shingles) are less contagious than those with varicella
(chickenpox), susceptible household contacts can develop varicella after exposure to herpes zoster, usually by means of direct contact with
the lesions.15 The most common complication of herpes zoster is postherpetic neuralgia; the pain is described as continuous aching, itching
or burning.11 See photo, Herpes Zoster.
Photo 5: Herpes Zoster (Shingles)

Characteristics of Selected Viral Skin Rashes
Table 1: Characteristics of Selected Viral Skin Rashes

Disease Prodromal Features Skin Eruptiona Incubation Infectious Differential Prevention Treatment Most
Period Period Diagnosis Common
Season of
Occurrence
Rubeola 3–4 days of fever, Erythematous 8–12 days 1–2 days Morbilliform Measles Supportive Winter/
(Measles) cough, coryza, macules and before rash: Similar to vaccine care (e.g., spring
photophobia, papules prodrome drug eruptions antipyretics)
conjunctivitis, appear initially until 4 days and viral
Koplik spots behind ears after skin exanthems;
and along eruption Koplik spots
hairline and generally
spread diagnostic
downward.
Fade by day 5
of eruption
Rubella Children: Usually Starts on face 14–21 5–7 days Nonspecific Rubella Supportive Spring
(German none or mild fever and neck as days prior to viral vaccine care (e.g.,
Measles) and mild pink eruption exanthems, antipyretics)
lymphadenopathy erythematous until 3–5 drug eruptions
Adolescents/adults: macules and days after
Fever, malaise, sore papules, and
throat, nausea, generalizes
painful occipital over 1–2 days.
lymphadenopathy Lesions fade
within 2–3
days
Erythema Children: Mild fever, Red 4–14 days Prior to Systemic None Supportive Winter/
Infectiosum sore throat and erythematous onset of lupus care spring
(Parovirus malaise macules on eruption erythematosus
Infection/Fifth Adults: Flu-like cheeks with (only (butterfly
Disease) symptoms, “slapped considered pattern over
arthralgias and cheek” mildly the bridge of
arthritis appearance contagious) the nose)
followed by
maculopapular
eruption on
proximal
extremities,
which fades
from centre
out producing
reticulated
“lacy” pattern.
Resolves in 1
wk
Roseola High fever for 3–4 Lesions start 7–15 days During Measles, None Supportive Spring/fall
Infantum days on chest and illness scarlet fever, care
(Sixth rapidly rubella
Disease); generalize into
(Human a pink
herpes virus 6 maculopapular
or 7 infection) eruption. Fade
within 24–48 h
Disease Prodromal Features Skin Eruptiona Incubation Infectious Differential Prevention Treatment Most
Period Period Diagnosis Common
Season of
Occurrence
Gianotti-Crosti Upper respiratory Sudden Unknown Unknown Lichen planus, None Usually Spring/early
Syndrome infection in one- eruption of drug eruption, none summer
(Papular third of patients flat-topped, pityriasis required
Acrodermatitis nonpruritic rosea
of Childhood) erythematous
papules that
are
symmetrically
distributed
over face,
buttocks and
extremities.
Resolves in 2–
8 wk
Hand, Foot Absent or mild and Blisters or 4–6 days From first Unique None Good oral Summer/fall
and Mouth occur 1–2 days ulcers appearance disease based hydration
Disease before lesions. Low- surrounded by until blister- on incubation
grade fever, red halos form like lesions period and
anorexia, malaise, in the back of disappear distribution of
sore mouth mouth and on lesions
tongue, palms,
soles, and
buttocks
Varicella None to fever, Erythematous 10–21 Two days Insect bites Varicella Children: Sporadic
(Chickenpox) malaise, cough, macules which days prior to during early vaccine Supportive
sore throat develop eruption stages. care
central until 5 days Kaposi's Adults:
vesicles and 2 after varicelli-form Antivirals
days later eruption (e.g.,
pustules and (eczema acyclovir,
crusts. Total herpeticum) famciclovir)
healing 16
days
Herpes Zoster Children: None Occur in a Not Until Insect bites, Zoster Children: Sporadic
(Shingles) Adults: Dull ache up dermatomal applicable primary herpes vaccine, None
to 1 wk prior to distribution crusts have simplex virus live Adults:
eruption and consist of healed attenuated Antivirals
grouped within 48–
vesicles and 72 h of
bullae on an initial
erythematous appearance
base. Persist of lesions
for 10–14
days
a See Drug-Induced Skin Reactions, Table 1: Dermatologic Terminology.
Goals of Therapy
Minimize patient discomfort
Shorten duration of symptoms when possible
Patient Assessment
An assessment for pediatric patients with a skin eruption is found in Figure 1. Prior to recommending a product for symptomatic relief, evaluate
the severity of the patient's condition.
Patients require further assessment by an appropriate healthcare practitioner when:
The causative factor/organism is uncertain

Fever and/or malaise is associated with the skin eruption
The patient has an underlying condition, such as diabetes, cancer or HIV infection, or the patient is on chronic corticosteroid therapy or
other immunosuppressive therapy.
Note that many other eruptions induced by viral infections (e.g., herpes simplex, eruptions associated with respiratory and enteric viruses) are
not included in Figure 1.
Prevention
Hand hygiene is one of the most effective methods of preventing transmission of pathogens. As many viral skin rashes are spread via respiratory
droplets, respiratory hygiene (cough etiquette) should also be used to help prevent transmission.16
Vaccines have been developed for the prevention of herpes zoster, measles, rubella and varicella. For current recommendations on immunization
schedules for infants and children for the measles, mumps and rubella vaccine, see the Canadian Immunization Guide.17 The varicella virus
vaccine is recommended for primary vaccination of healthy persons 12 months of age or older who are susceptible to the disease.17 Although
herpes zoster vaccine is safe and immunogenic in patients 50 years of age and older, the greatest benefit is observed in those 60 years and
older. It is recommended for prevention of herpes zoster and its complications, in persons 60 years and older without contraindications.18,19
High-risk patients, such as those with cancer or HIV infection, should avoid exposure to patients with viral skin eruptions. All women of child-
bearing age should be tested for rubella antibodies and vaccinated if necessary, prior to pregnancy. The varicella virus vaccine is contraindicated
during pregnancy; pregnant women not previously infected with chickenpox should avoid contact with infected individuals.17
Minimizing patient discomfort is key, and often the only treatment that can be offered to patients with a viral skin eruption.
Many viral skin eruptions are associated with intense pruritus. Since it is exacerbated by dry skin, using a simple emollient is often helpful. A
humidifier can also be used, although in some patients high humidity may also cause pruritus secondary to sweat retention. Recommend good
hygiene practices including gentle cleansing and drying of lesions as well as trimming of fingernails, to prevent bacterial infection that may
develop from scratching the pruritic lesions. The sensation of itching is generally increased if the skin is warm. Therefore, cooling the skin by
tepid showering or bathing can often bring relief. As well, rubbing an ice cube over the rash or covering the rash with a clean cloth soaked in cold
water will provide temporary relief.
Avoiding factors that may enhance pruritus, such as wearing of tight elasticized apparel or coarse woolen fabrics, is also important. Cornstarch
or sodium bicarbonate baths have been used to relieve itching in patients with chickenpox. Add 2 cups of cornstarch mixed with 4 cups of water
to a bathtub full of water. Bathing is recommended once or twice daily for approximately 15–20 minutes. The skin should be gently patted, not
rubbed, when drying.
Remind patients to stay well hydrated by drinking plenty of fluids, which can include popsicles and gelatin.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Analgesic Products: External
Analgesics; Skin Care Products: Dermatitis and Dry Skin, First Aid.
Colloidal oatmeal bath preparations may help to relieve pruritus. To be effective the product should be well dispersed in the bathtub water. For
dispersion, the patient should fill a strainer with oatmeal bath preparation and hold under the faucet as water fills the tub. Unscented moisture
cream or white petrolatum should be applied to the skin while it is slightly damp to retard water evaporation.
Local agents are useful for relieving pruritus and for reducing bacterial colonization of damaged skin. Cool compresses (e.g., gauze or other thin
cloth moistened with water) applied for 20 minutes 4–6 times daily can be used, especially for weeping, oozing lesions. Calamine lotion can be
applied after removal of the wet compresses. Other traditional topical agents including menthol, camphor and phenol are no longer
recommended. Concern has been raised over possible phenol toxicity, which has been described in patients with extensive bullous poison ivy
who developed renal toxicity.20 The American Academy of Pediatrics recommends that camphor not be used in children due to adverse effects
associated with even minor systemic absorption.21
Local anesthetics block conduction along axonal membranes, thereby relieving itching as well as pain. However, topical local anesthetics (e.g.,
benzocaine) are not recommended due to risk of sensitization, especially if applied to broken or fissured skin.22 Pramoxine has less risk of
sensitization than other local anesthetics, and may be used topically as an antipruritic. Topical lidocaine has demonstrated efficacy for relief
of neuropathic pain (including postherpetic neuralgia), in several low-quality studies.23 However, the typical large size of the area to be treated
and the need for occlusion limit the routine use of local anesthetics in this situation.
Topical corticosteroids may relieve the itching associated with the skin lesions but are not frequently used as most viral-induced skin eruptions
are self-limiting and topical corticosteroids do not improve the natural history of the disease. Mild topical corticosteroids such as 0.5 or 1%
hydrocortisone, can be used on the face and intertriginous folds. Ointments are more occlusive and are preferred for dry or scaly lesions,
whereas creams are used in moist areas since they are more drying. Lotions are useful for the scalp and other hairy areas or for application to
large body areas. Topical corticosteroids should not be used on bacterial- or fungal-infected skin since the corticosteroid may mask the
symptoms of the dermatologic infection and allow the infection to progress. If the skin lesions persist or worsen after 5–7 days of topical
corticosteroid therapy, the patient should seek further assessment and/or treatment. There is some evidence that medium-potency topical
corticosteroids may decrease the duration of lesions of Gianotti-Crosti syndrome when applied once daily for 1–2 weeks. However, patients
should be monitored closely, as there have been reports of worsening symptoms with the use of topical corticosteroids.24 For further discussion
on the use of topical corticosteroids, consult the Compendium of Therapeutic Choices: Atopic Dermatitis.
Capsaicin 0.025% cream is a topical preparation made from the naturally occurring substance found in hot chili peppers. Applied to the affected
area at least 3–4 times daily, it is effective in the treatment of postherpetic neuralgia.25 Local burning, stinging and irritation are common
although they usually disappear with repeated application.
Although H1-blocking antihistamines have been used for the treatment of pruritus especially associated with urticaria, they are often not
effective for viral-induced skin lesions. However, sedating or first-generation antihistamines are often used at bedtime to improve sleep.26 See
Allergic Rhinitis for adult and pediatric doses of oral antihistamines. Topical diphenhydramine is usually not recommended because of the risk of
sensitization resulting in contact dermatitis.26
Many viral diseases are associated with a fever, especially in the prodromal stages. Antipyretics can be recommended to provide symptomatic
relief; however, they do not reduce risk of recurrent febrile seizures.27
Acetaminophen is recommended as the first-line antipyretic agent in children with chickenpox (see Fever for adult and pediatric doses of
antipyretics). Although acetaminophen was found to delay the clearance of the varicella zoster virus, as shown by delayed scabbing of the
lesions,28 the clinical significance of this is not known. The use of NSAIDs in children with chickenpox may increase the risk of necrotizing soft
tissue infections and secondary infections caused by invasive streptococci.29,30,31 [Evidence: SORT B]
Avoid ASA because of the possible association of Reye's syndrome with salicylate administration32 especially in children and teenagers with
viral infections.33 Reye's syndrome is an acute, noninflammatory enecephalopathy and hepatotoxicity that follows an acute viral illness.34 In
some countries ASA use is still recommended in children. Parents who travel abroad should be warned regarding this potential risk.35 There are
no case reports of Reye's syndrome in patients with herpes zoster receiving ASA for cardiovascular prophylaxis; many clinicians elect to continue
ASA during the acute illness. If analgesics are required in these patients, recommend acetaminophen or ibuprofen as there is no association
between these agents and the development of Reye's syndrome.
Mild analgesics (e.g., NSAIDs other than ASA, acetaminophen) are sometimes recommended for the treatment of acute pain associated with
herpes zoster, but are often not effective. The pain in acute herpes zoster is frequently moderate to severe and warrants the use of opioid
analgesics.36
For patients with mouth lesions, recommend warm water rinses or saline rinses (5–15 mL of table salt in 125–250 mL of warm tap water.)
Hydrogen peroxide (half-strength) has also been used as a mouth rinse. Frequent oral hygiene with a soft-bristled toothbrush is recommended.
Patients should avoid alcohol- and glycerin-based mouthwashes; petrolatum jelly can be applied to lips as needed.
Antiviral therapy may be used in select patients:

Chickenpox: If initiated within 24 hours of rash onset, acyclovir may decrease the total number of new lesions formed and lower the need
for antipruritic and analgesic treatment. In immunocompetent children, acyclovir is not generally recommended. However for
immunocompetent adults and all immunocompromised hosts, treatment with acyclovir is suggested.37 Although no randomized control
trial evidence is available and it is not an approved indication, valacyclovir and famciclovir have been used for the treatment of chickenpox
in healthy adults.10
Acute herpes zoster: Antiviral therapy with acyclovir, valacyclovir or famciclovir speeds resolution of the acute lesional events and perhaps
reduces the risk of prolonged pain. In patients 50 years of age and over or any patient with moderate to severe acute pain, antiviral therapy
should be initiated if the duration of the rash is less than 72 hours. However, antiviral treatment should be considered even in patients who
present more than 72 hours after rash onset, particularly in the presence of new vesicle formation or complications.14
For further discussion of pharmacologic therapy for chickenpox and acute herpes zoster, consult the Compendium of Therapeutic Choices:
Herpesvirus Infections.
For further information on topical therapy for viral skin rashes, see Table 3.
Although witch hazel (hamamelis water) has traditionally been used for skin irritations, bruises and hemorrhoids, clinical data to support its
efficacy in these conditions are limited.38
A monitoring plan for patients with viral rashes is outlined in Table 2. Additional advice should be provided regarding:
Time frame during which patients are considered infectious

Assessment by appropriate healthcare practitioner for possible use of antivirals in patients with herpes zoster and varicella (especially
adults and those who are immunocompromised).
Table 2: Monitoring of Therapy for Viral Skin Rashes

Pruritus associated with skin Patient: Daily while on To decrease itching If therapy ineffective after 24–48 h and
eruption therapy within 24–48 h treatment still required, patient requires
Healthcare practitioner: further assessment.
After 2 days of therapy or
next pharmacy visit
Fever Patient: BID while on To decrease fever within If fever persists for more than 48 h, patient
therapy 4–6 h of therapy requires further assessment and/or
Healthcare practitioner: treatment.
After 2 days or next visit
Pain, especially with herpes Patient: Daily To decrease pain to If pain persists despite appropriate
zoster Healthcare practitioner: acceptable levels for the analgesic medication, patient requires
Within 24 h of initiating patient within 24 h further assessment and/or treatment.
therapy
Sedation (due to Patient: Daily No sedation, especially if

antihistamine therapy: this Healthcare practitioner: patient driving or using
may be a desired effect of After 3 days or next visit heavy machinery
therapy)
Algorithms
Figure 1: Assessment of Pediatric Patient with Skin Eruption
a Many viral-induced eruptions (e.g., herpes simplex, eruption associated with respiratory and enteric viruses) are not included in this assessment.
b See Drug-Induced Skin Reactions.
Drug Table
Table 3: Topical Treatments for Viral Skin Rashes
Analgesics, capsaicin Apply to Local burning, stinging and irritation are common Used for $$
topical Zostrix, affected but disappear with repeated application. treatment of
generics area at postherpetic
least TID– neuralgia.
QID
Corticosteroids, hydrocortisone Apply to Striae, telangiectasia, atrophy, purpura. When Useful for $
topical,b,c 0.5%, 1% affected used around the eye for longer periods of time, noninfected,
cream, lotion, area TID– ocular side effects may rarely occur. Systemic non-
ointment QID for up effects include suppression of HPA axis although weeping
Cortate, to 7 days clinically relevant features are very rare. lesions.
generics Cream:
Moist areas.
Ointment:
Dry or scaly
lesions.
a Cost of 30 g; includes drug cost only.

b Since viral exanthems are self-limiting, topical corticosteroids are generally not recommended.
c For further information on other topical corticosteroids, consult the Compendium of Therapeutic Choices: Atopic Dermatitis and Corticosteroids: Topical
(CPhA Monograph).
Legend: $ <$5 $$ $5–10
Suggested Readings
Folster-Holst R, Kreth H. Viral exanthems in childhood-infectious (direct) exanthems. Part 1: Classic exanthems. J Dtsch Dermatol Ges
2009;7:309-16.
Folster-Holst R, Kreth H. Viral exanthems in childhood-infectious (direct) exanthems. Part 2: Other viral exanthems. J Dtsch Dermatol Ges
2009;7:414-9.
References
1. World Health Organization. Measles. Fact sheet no 286. Reviewed March 2016. Available from:
www.who.int/mediacentre/factsheets/fs286/en/index.html.
2. Moss WJ, Griffin DE. Measles. Lancet 2012;379:153-64.
3. Dyer JA. Childhood viral exanthems. Pediatr Ann 2007;36:21-9.
4. Centers for Disease Control and Prevention (CDC). Elimination of rubella and congenital rubella syndrome-United States, 1969-2004.
MMWR Morb Mortal Wkly Rep 2005;54:279-82.
5. Folster-Holst R, Kreth H. Viral exanthems in childhood-infectious (direct) exanthems. Part 1: Classic exanthems. J Dtsch Dermatol Ges
2009;7:309-16.
6. Scott LA, Stone MS. Viral exanthems. Dermatol Online J 2003;9:4.
7. Nelson JS, Stone MS. Update on selected viral exanthems. Curr Opin Pediatr 2000;12:359-64.
8. Folster-Holst R, Kreth H. Viral exanthems in childhood-infectious (direct) exanthems. Part 2: Other viral exanthems. J Dtsch Dermatol Ges
2009;7:414-9.
9. Wong SS, Yip CC, Lau SK et al. Human enterovirus 71 and hand, foot and mouth disease. Epidemiol Infect 2010;138:1071-89.
10. Breuer J, Fifer H. Chickenpox. Clin Evid (Online) 2011;pii:0912.
11. McCrary ML, Severson J, Tyring SK. Varicella zoster virus. J Am Acad Dermatol 1999;41:1-14.
12. Sauerbrei A, Wutzler P. The congenital varicella syndrome. J Perinatol 2000;20:548–54.
13. Mandelbrot L. Fetal varicella—diagnosis, management and outcome. Prenat Diagn 2013;32:511–8.
14. Sampathkumar P, Drage LA, Martin DP. Herpes zoster (shingles) and postherpetic neuralgia. Mayo Clin Proc 2009;84:274-80.
15. Schmader KE, Oxman MN. Varicella and herpes zoster. In: Goldsmith LA et al., eds. Fitzpatrick's dermatology in general medicine. 8th ed.
New York: McGraw Hill Medical; 2012.
16. World Health Organization. Infection control standard precautions in health care. 2006. Available from:
www.who.int/csr/resources/publications/4EPR_AM2.pdf.
17. Public Health Agency of Canada. National Advisory Committee on Immunization (NACI). Canadian immunization guide. Evergreen ed.
Available from: www.phac-aspc.gc.ca/publicat/cig-gci/index-eng.php. Accessed april 12, 2016.
18. Gagliardi AM, Gomes Silva BN, Torloni MR et al. Vaccines for preventing herpes zoster in older adults. Cochrane Database Syst Rev
2012;10:CD008858.
19. Public Health Agency of Canada. An Advisory Committee Statement (ACS). National Advisory Committee on Immunization: (NACI).
Update on the use of herpes zoster vaccine. January 2014. Available from: publications.gc.ca/collections/collection_2014/aspc-
phac/HP40-92-2014-eng.pdf. Accessed June 6, 2015.
20. Millikan LE. Pruritus: unapproved treatments or indications. Clin Dermatol 2000;18:149-52.
21. Camphor revisited: focus on toxicity. Committee on Drugs. American Academy of Pediatrics. Pediatrics 1994;94:127-8.
22. Warshaw EM, Schram SE, Belsito DV et al. Patch-test reactions to topical anesthetics: retrospective analysis of cross-sectional data,
2001 to 2004. Dermatitis 2008;19:81-5.
23. Derry S, Wiffen PJ, Moore RA et al. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst Rev 2014;7:CD010958
24. Belazarian LT, Lorenzo ME, Pearson AL et al. Exanthematous viral diseases. In: Goldsmith LA et al., eds. Fitzpatrick's dermatology in
general medicine. 8th ed. New York: McGraw Hill Medical; 2012.
Benign Prostatic Hyperplasia and Associated Lower Urinary Tract
Symptoms
Cheryl A. Sadowski, BSc(Pharm), PharmD

Introduction
Lower urinary tract symptoms (LUTS) has become an umbrella term encompassing a broad range of urinary
symptoms experienced by men and women.1 This global term includes all urinary symptoms associated
with storage, voiding and/or postmicturition.1 This chapter focuses on those symptoms associated with
benign prostatic hyperplasia (BPH). Urinary Incontinence covers common types of urinary incontinence in
women and men, not in association with BPH.
Pathophysiology
BPH is used to describe the histologic changes associated with prostatic enlargement which may or may
not be associated with urethral obstruction.2 It is the most common benign neoplasm in the aging human
male.
The prostate is a walnut-sized gland at the base of the bladder that completely surrounds the male urethra
(Figure 1). Its functions include contributing fluid to the ejaculate and constriction of the prostatic urethra
during ejaculation (to prevent retrograde ejaculation). The prostate normally goes through 2 main periods of
growth. The first is during puberty, when the prostate doubles in size. The second begins around age 25
years and may be the cause of BPH much later in life.3 Symptoms of BPH rarely become apparent before
age 40 years. The prevalence of BPH, measured histologically, is 8% for men in their thirties, 20% for men in
their forties and up to 90% in men in their seventies.4,5
Figure 1: Male Reproductive Anatomy
No single pathological mechanism occurs in BPH, but rather a synergy of events.6 The pathophysiology of
BPH is incompletely understood but appears to be related to androgens, aging, prostatic inflammation and
genetics.7,8,9,10 Increases in circulating androgens are considered partly responsible for an alteration in
basal cell hyperplasia and increases in stromal and epithelial mass.11,12 However, testosterone is only partly
to blame, as some men do not respond to antiandrogen treatments.12 Dihydrotestosterone (DHT), a potent
metabolite of testosterone, is believed to be the main androgen responsible for both normal and
hyperplastic prostate growth.13,14,15 Testosterone is metabolized to DHT by the enzyme 5-alpha-reductase.
Early in the process, BPH manifests as microscopic nodules in the periurethral area, followed by progressive
nodular proliferation that may lead to bladder outlet obstruction and subsequent symptoms of BPH.14,15
Due to an age-related decline in detrusor muscle strength and prostatic enlargement, the urinary flow rate
declines from >15 mL/sec (normal) to <10 mL/sec.16 A normal prostate is approximately 20–30 mL in
volume. Smooth-muscle fibres may compose up to 40% of the volume of a prostate affected by BPH. The
bladder neck, stroma and capsule are richly innervated with alpha-1A adrenergic receptors that control
smooth muscle contraction.15,17
LUTS associated with BPH can be divided into 3 categories: storage (irritative), voiding (obstructive), and
postmicturition symptoms (Table 1). For most men, the symptoms appear gradually, over many years. In
others, symptoms appear acutely. If left untreated, BPH may contribute to impaired bladder emptying and
lead to hydronephrosis, bladder stones and recurrent urinary tract infections.18,19 Other complications
include impaired sleep, decreased quality of life and a higher risk of erectile dysfunction.20,21
These complications may or may not be prevented with treatment. In many men, particularly those with mild
symptoms, watchful waiting is an appropriate approach to treatment.21,22 Usually an International Prostate
Symptom Score (IPSS) ≤7 dictates watchful waiting, but some men with scores up to 19 (moderate
symptoms) may choose watchful waiting if they are not particularly bothered by the symptoms (Table
2).16,23 Progression rates may be variable and are difficult to predict.
18,24
Table 1: Urinary Symptoms of BPH
Voiding (Obstructive symptoms) Storage (Irritative Postmicturition
symptoms)
Weak urinary stream Urinary frequency Sensation of incomplete
Hesitancy (difficulty initiating Nocturia bladder emptying
stream) Pain during micturition Postvoid dribbling
Intermittency Urinary urgency
Straining
Terminal dribbling
Urinary retention
Goals of Therapy
Alleviate symptoms of BPH
Prevent complications, including acute urinary retention, acute renal failure and urinary tract infections
Minimize adverse effects of treatment
Patient Assessment
Patients with suspected BPH should undergo a focused evaluation. Not all patients with BPH are
symptomatic, and many may not receive a diagnosis for many years.25,26 Due to the high rates of BPH with
aging and other comorbidities, such as diabetes and erectile dysfunction, ask men over 50 and those with
these conditions about their medical history and symptoms of BPH.26,27,28,29,30,31,32
Men assessed for BPH will undergo many of the tests as for other types of LUTS (see Urinary Incontinence).
However, details about BPH symptoms can be gleaned from using the International Prostate Symptom Scale
(IPSS) questionnaire specific to BPH (Table 2). This is a simple scale that can be completed by the patient or
his healthcare practitioner for quantifying the severity of BPH symptoms. This index should be performed at
the onset of therapy and periodically thereafter to monitor the success of treatment. It is not validated as a
tool to diagnose BPH.
26,33
Table 2: International Prostate Symptom Score for BPH Assessment
Questions to be answered Less
Less than
than half More
Not at 1 time in the About half than half Almost
all 5 time the time the time always
Circle 1 number on each line
1. Incomplete emptying: 0 1 2 3 4 5
Over the past month, how
often have you had a
sensation of not emptying
your bladder completely
after you finished
urinating?
2. Frequency: 0 1 2 3 4 5
often have you had to
urinate again less than 2 h
after you finished
urinating?
3. Intermittency: 0 1 2 3 4 5
often have you found you
stopped and started again
several times when you
urinated?
4. Urgency: 0 1 2 3 4 5
often have you found it
difficult to postpone
urination?
5. Weak stream: 0 1 2 3 4 5
often have you had a
weak urinary stream?
6. Straining: 0 1 2 3 4 5
often have you had to
push or strain to begin
urination?
7. Nocturia: 0 1 2 3 4 5
many times, most
typically, did you get up to
urinate from the time you
went to bed at night until
the time you got up in the
morning?
Sum of 7 circled numbers:a
Quality of life due to urinary symptoms
If you were Delighted Pleased Mostly Mixed Mostly Unhappy Terrible

to spend satisfied dissatisfied
the rest of
your life
with your
urinary
condition
just the way
it is now,
how would
you feel
about that?
a Symptoms are classified as: Mild = Score 0–7; Moderate = Score 8–19; Severe = Score 20–35
Reproduced with permission from Lippincott Williams & Wilkins. Barry MJ, Fowler FJ, O'Leary MP et al. The American Urological Association
symptom index for benign prostatic hyperplasia. J Urol 1992;148:1549-57.
Physical examination should include the abdomen, external genitalia and prostate (e.g., digital rectal exam).
Blood work that could identify underlying comorbidities (e.g., diabetes) and a urinalysis are also
important.18,26,31,32,33 The measurement of prostate specific antigen (PSA) should be considered,
especially in men with a positive family history of prostate cancer and those of African descent, but it is
controversial because elevated PSA is not specific to the diagnosis of prostate cancer.19,34 The AUA
Guidelines no longer recommend measuring a serum creatinine to evaluate renal function in men with
BPH.35 Additional testing (e.g., urodynamics, bladder scanning) may be done to assess changes in lower
urinary tract function.19 The purpose of these additional tests is to monitor the progression of BPH and to
help rule out cancer, bladder stones, urinary tract infections and other comorbidities that could mimic urinary
retention in men.19,33,34,36
Several medications may exacerbate symptoms of BPH (Table 3). These drugs primarily act through
anticholinergic properties and inhibit bladder contraction; others possess stimulant sympathomimetic
properties and increase urethral resistance.37
Table 3: Examples of Drugs that May Exacerbate Symptoms of BPH

Androgens Antihistamines Sympathomimetics
testosterone brompheniramine phenylephrine
Anticholinergics chlorpheniramine pseudoephedrine
benztropine cyproheptadine terbutaline
flavoxate dimenhydrinate Miscellaneous
glycopyrrolate diphenhydramine caffeine
hyoscine hydroxyzine ipratropium
oxybutynin Antipsychotics NSAIDs
scopolamine fluphenazine pizotifen
tiotropium (inhaled) loxapine procyclidine
tolterodine olanzapine selegiline
Antidepressants Muscle relaxants
amitriptyline baclofen
doxepin cyclobenzaprine
nortriptyline
Treatment
Treatment is recommended only when BPH becomes bothersome, poses a health risk or is associated with
complications (e.g., recurrent urinary infections, renal insufficiency).32,35,38 Mild BPH does not require
treatment and in approximately 15% of cases, symptoms will stabilize or resolve without treatment.38,39,40
Treatment of BPH can include lifestyle changes, drug therapy or surgery.
Lifestyle Changes
The following may be helpful in reducing BPH symptoms:21,25,32,41
Medical
blood pressure control
body weight reduction
management of constipation
Behavioural
smoking cessation
increased exercise
caffeine and alcohol reduction
regular or timed urination
redistribution of liquid consumption to earlier in the day
double-voiding or penile milking techniques
Medication
adjustment of medication dosage or timing (e.g., diuretics)
Psychosocial
self-help groups42,43
Watchful Waiting
Offer watchful waiting (also termed “informed surveillance”) to patients with mild symptoms (IPSS score
≤7) which are not particularly bothersome.16,32,33,35 Reassess these patients at yearly intervals or earlier
if there is a change in the symptom complex.23 These patients should still be counselled to make
lifestyle changes, such as limiting late day fluid consumption, taking diuretics earlier in the day, and
avoiding stimulants (e.g., caffeine).17,21
Surgical Procedures
Transurethral resection of the prostate (TURP) remains the gold standard, with almost 90% of men
reporting reduced symptom scores. However, due to risks associated with this procedure, less invasive
therapies continue to be developed but none has replaced it to any great extent. Minimally invasive
procedures do not remove tissue but cause necrosis by heat. Most procedures require spinal or general
anesthesia and all (Table 4) have a risk of erectile dysfunction, retrograde ejaculation and incontinence.
Table 4: Surgical Procedures for Managing BPH

Procedure Indication Comments
Transurethral resection of For moderately enlarged The gold standard.
the prostate (TURP)44 prostates A diathermy loop removes the inner
(periurethral) zones of the prostate.
Advantages: Fewer work days lost
and fewer days in hospital than with
open surgery. Highest degree of
symptom improvement (80–90%) of
all procedures. Symptom
improvement is long lasting.
Disadvantages: Requires spinal or
general anesthetic. Requires
catheterization for 1–3 days post-
operatively.
Complications: Up to 20% of patients
have morbidity related to TURP.
Failure to void, bleeding (5%), clot
retention, retrograde ejaculation.
Transurethral For moderately enlarged Less bleeding than with TURP, but
electrovaporization of the prostates higher rates of irritative symptoms
prostate (TUVP) and re-catheterization. Can be done
as day surgery. Requires spinal or
general anesthesia.
Transurethral incision of For smaller prostates Lower incidence of complications

the prostate (TUIP) (<30 mL) including retrograde ejaculation and
fewer days in hospital than with open
surgery or TURP. Symptomatic
improvement is similar to TURP.
Takes only minutes to perform
procedure. Requires spinal or general
anesthesia.
Open prostatectomy For large prostates (>80 Most thorough excision of adenoma
mL) or patients with of all the procedures. Higher rates of
specific concomitant urinary incontinence and bladder
conditions (e.g., bladder neck stenosis. Requires spinal or
diverticula or stones) general anesthesia.
Urethral stent Patients unfit for surgery Can be done as outpatient procedure.
or high-risk patients with Usually done under regional or
chronic urinary retention. topical anaesthesia. Complications:
Temporary stenting for Failure 20–30%, urinary tract
patients who have infections, pain.
undergone minimally
invasive procedures and
require short-term relief
Procedure Indication Comments
Minimally Invasive Procedures45,46
Transurethral microwave Ideally used in men with Can be done as an outpatient

thermotherapy (TUMT) smaller prostate volumes procedure using analgesia and/or
(30–100 mL), no history sedation.
of retention, no previous Require catheterization following the
prostate surgery procedure.
Repeat or more invasive treatment is
usually required in approximately
Transurethral needle 30% of men.
ablation (TUNA) Risk of retrograde ejaculation lower
than for invasive procedures.
Usually lower response in symptoms
and quality of life versus TURP, with
higher retreatment rates.
Ablative Procedures
Holmium laser Any prostate size Can be done as outpatient procedure,

enucleation of the Men on anticoagulants, or less blood loss than with most other
prostate (HoLEP) those with cardiac or procedures.
renal disease Earlier discharge from hospital
Holmium laser resection versus other procedures.
of the prostate (HoLRP) Risk of retrograde ejaculation similar
to invasive procedures.
Holmium laser ablation of Requires spinal or general
the prostate (HoLAP) anesthesia.
Photoselective
vaporization of the
prostate (PVP)
For further discussion of pharmacologic therapy for BPH and related symptoms, consult the Compendium of
Therapeutic Choices: Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia.
The main pharmacologic options used for treating BPH include the 5-alpha-reductase inhibitors
(dutasteride, finasteride) and alpha-adrenergic receptor antagonists (alfuzosin, doxazosin, silodosin,
tamsulosin and terazosin).25 Due to their distinct pharmacologic actions, these medication classes may be
used together, with the alpha-antagonists working within 1–2 weeks and the 5-alpha-reductase inhibitors
working within 3–6 months.47,48,49 Combination treatment seems to be most effective for patients with
prostate volumes >30–40 mL, with greater reduction in IPSS scores and higher urinary flow rates compared
with monotherapy. In addition to higher costs, adverse events are approximately 50% greater in dual vs.
monotherapy, which leads to higher rates of treatment discontinuation.50 Consider combination therapy only
when monotherapy is not meeting the treatment goals. Medications are effective in approximately 60% of
men.25,51 The phosphodiesterase-5 inhibitor tadalafil has been increasingly used for the treatment of LUTS
due to BPH and has shown improvement in symptoms and quality of life in men with or without concomitant
ED.32,52
5-Alpha-reductase Inhibitors
Dutasteride and finasteride reduce intraprostatic DHT concentrations by inhibiting 5-alpha-reductase

(type 2). This shrinks the prostate by 25%, reduces serum PSA by 50%, prevents further prostatic growth
and acute urinary retention, lowers the risk of required prostate surgery and reduces the IPSS by 4–5
points (up to 7 points when combined with an alpha-blocker).7,16,50,53 This class of medications appears
to work best when the prostate volume is ≥40 mL.54 Long-term usage is required because progressive
clinical benefits are not manifest until 3–6 months after initiation of therapy.55
Up to 5% of patients taking these medications experience adverse effects such as decreased libido,
erectile dysfunction, breast tenderness and gynecomastia.7,36,53,56
Alpha-adrenergic Antagonists
Stromal and fibromuscular tissues are under alpha-adrenergic control. Alpha-blockers antagonize the
binding of norepinephrine to the alpha receptors in the prostate gland and bladder neck. This results in
smooth muscle relaxation and improved urine flow through the bladder outlet but does not reduce the
size of the prostate gland.16,57,58,59 Benefit is seen within the first 2 weeks, with the full effect realized
after titration to full therapeutic dose.60,61 There is no evidence of tachyphylaxis. All alpha-adrenergic
antagonists used for BPH symptoms have been found to be equally effective when dosed
therapeutically.62,63,64 This class of medications reduces the IPSS by 6 points and improves symptoms
associated with voiding in approximately 60–80% of patients, although men with larger prostates may
have less response.7,25,32,58
Adverse effects associated with alpha-adrenergic antagonists (dizziness, headache and peripheral
edema) are attributed to the effect on alpha receptors in vascular and central nervous tissue, and occur
in up to 15% of patients.30,35,65 Less common side effects include rhinitis and ejaculatory dysfunction
(e.g., retrograde ejaculation).66 There is also a risk of ophthalmic complications after cataract surgery, as
alpha receptors are also found on the iris.67 To minimize adverse effects such as dizziness or postural
hypotension, the second-generation agents (doxazosin, terazosin) are taken at bedtime, started at low
doses and titrated upward over several weeks. Alfuzosin, silodosin and tamsulosin are more specific for
the alpha-1A receptors found in the prostate gland and as such are usually not associated with
significant hypotensive episodes and do not require dose titration.
Phosphodiesterase-5 Inhibitors
Low-dose daily tadalafil is currently the only phosphodiesterase-5 inhibitor (PDE5-I) indicated for use in
BPH with or without erectile dysfunction. PDE-5 enzyme exists in prostatic tissue, bladder detrusor and
vascular smooth-muscle cells of the urinary tract.68 Tadalafil causes smooth muscle relaxation and may
provide some antiproliferative effects in the prostate. Improvement in symptoms may occur as early as
1–4 weeks.32 PDE5-Is have been shown to reduce IPSS scores by 4–6 points after 12 weeks of
treatment.69,70,71 Expected side effects include headache, dyspepsia and dizziness.
Antimuscarinics
These medications (e.g., darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine)72 are used to
treat the storage-related symptoms of BPH by decreasing the overactive bladder component. The AUA
Guidelines recommend using these drugs with caution if the postvoid residual is >250 mL.35 They are
beneficial when used with an alpha-blocker, improving the IPSS by as much as 4 points, reducing
postvoid residual volume and reducing voiding frequency.7,73,74 Adverse effects (e.g., urinary retention,
dry mouth, constipation) can be minimized by using these medications intermittently or in low doses.75
Natural health products that have been widely promoted for BPH treatment include saw palmetto,
African plum tree (Pygeum africanum), stinging nettle and pumpkin seeds (Table 5). The evidence for
their effectiveness is variable and their role in treating BPH remains unclear.76,77,78 The AUA, the
European Association of Urology, and the International Consultation for Urological Diseases guidelines
do not recommend the use of any phytotherapies.35,36,79 However, many men self-medicate with these
products and some respond well subjectively.
To ensure effectiveness and tolerability of medications, patients should be evaluated within a few months of
starting treatment and monitored regularly thereafter. Improvements in the IPSS may be especially helpful in
confirming clinical benefit.
Patients taking an alpha-adrenergic antagonist with or without a 5-alpha-reductase inhibitor should be

questioned about the success and potential side effects of their therapy at every visit. Advise patients about
how to slowly titrate their alpha-adrenergic antagonist dosing regimen to avoid adverse effects (e.g.,
dizziness, postural hypotension) and to monitor for symptom change weekly.
Resource Tips
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Prostate enlargement: benign
prostatic hyperplasia. Available from: www.niddk.nih.gov/health-information/health-topics/urologic-
disease/benign-prostatic-hyperplasia-bph/Pages/facts.aspx.
The Prostate Centre at the Princess Margaret Hospital. Available from: /www.prostatecentre.ca.
Urological Sciences Research Foundation. International Prostate Symptom Score (IPSS). Available from:
www.usrf.org/questionnaires/AUA_SymptomScore.html.
Urology Care Foundation. The Official Foundation of the American Urological Association. Urologic
conditions. Available from: www.urologyhealth.org.
Drug Table
Table 5: Natural Health Products Used in Benign Prostatic Hyperplasiaa,b
Drug/Costc Dosage Mechanism of Action Adverse

Effects
cernilton 500 mg TID po Inhibition of 5-alpha-reductase, alpha- Mild nausea

receptor antagonist, smooth muscle
$ relaxation, inhibition of growth through
interference with androgen metabolism
Drug/Costc Dosage Mechanism of Action Adverse
Effects
pumpkin 10 g of seeds Inhibition of 5-alpha-reductase None known

seed per day or
equivalent
$
pygeum 50 mg BID po, Inhibition of 5-alpha-reductase, GI upset

africanum 100 mg daily po, antiandrogenic effects, inhibits growth ranging from
or 100 mg BID factors, reduces inflammatory nausea to
$ po (extract) mediators80 severe pain
saw 160 mg Inhibition of 5-alpha-reductase, Headache, GI

palmetto (lipophilic antiandrogenic effects, anti-inflammatory, upset,
extract) BID po triggers prostatic cell apoptosis, smooth hypertension,
$ or 1–2 g muscle relaxation80,81 impotence,
(berries) once decreased
daily po libido
soy 25–50 g/day po Inhibition of 5-alpha-reductase, Nausea

isoflavones androgenic blocking
stinging 150–300 mg Inhibits the binding of sex hormone- GI upset

nettle (root extract) binding globulin to its receptors, binds
once daily po epidermal growth factor
$
a Effectiveness and role in treating BPH is unclear. Use only if mild symptoms and if patient has chosen the watchful
waiting approach.
b For more information on pharmacologic therapy for BPH, consult the Compendium of Therapeutic Choices: Lower
Urinary Tract Symptoms and Benign Prostatic Hyperplasia.
c Cost of 30-day supply; includes drug cost only.
Legend: $ <$15
Suggested Readings
D'Silva KA, Dahm P, Wong CL. Does this man with lower urinary tract symptoms have bladder outlet
obstruction?: The Rational Clinical Examination: a systematic review. JAMA 2014;312:535-42.
Hollingsworth JM, Wilt TJ. Lower urinary tract symptoms in men. BMJ 2014;349:g4474.
McVary KT, Roehrborn CG, Avins AL et al. Update on AUA guideline on the management of benign prostatic
hyperplasia. J Urol 2011;185:1793-803.
Pagano E, Laudato M, Griffo M et al. Phytotherapy of benign prostatic hyperplasia. A minireview. Phytother
Res 2014;28:949-55.
Sarma A V, Wei JT. Clinical practice. Benign prostatic hyperplasia and lower urinary tract symptoms. N Engl J
Med 2012;367:248-57.
References
Contraception
Anne Marie Whelan, PharmD, FCSHP

Introduction
A woman can become pregnant from puberty until menopause, so contraception is an important health
issue for many women during these reproductive years. There were a total of 386,044 births in Canada in
2013–141 and 82,869 induced abortions,2 suggesting that many pregnancies in Canada may be unplanned.
Unplanned pregnancies have been associated with negative health and social outcomes for both mothers
and children.3,4,5
Healthy sexual practices, including the use of contraception, are important for countering these unplanned
pregnancies. Unsafe sexual behaviours may lead not only to unplanned pregnancy but also to infertility and
human immunodeficiency virus (HIV) or other sexually transmitted infections (STIs). However, the Canadian
Contraception Study (CCS), conducted in 2002, reported that among Canadians aged 15–44, 9% were not
using any method of contraception.6 The study also found that many women are not familiar with some of
the contraceptive methods available to them. Less than 50% of respondents were familiar with spermicides,
cervical caps, the rhythm method or the female condom.6
Many options are available for effective contraception, some of which, such as condoms, have the added
advantage of providing protection against HIV and other STI transmission. However, the 2002 CCS found
that among Canadians aged 15–18 who were coitally experienced, 17% had “sometimes” used a condom in
the past 6 months and 17% reported not using a condom ever in the past 6 months.7 These data highlight
the need for contraceptive counselling and enhanced public education starting at a young age.8 Healthcare
practitioners are in an excellent position to help women and men with their contraceptive choices by taking
into consideration desired outcomes as well as advantages and disadvantages of various methods. This
chapter focuses on nonhormonal contraceptive methods but also includes a discussion of hormonal
contraceptive methods and emergency contraception.
Pathophysiology
The female reproductive cycle comprises 2 main phases, the follicular or preovulatory phase and the luteal
or postovulatory phase. The first day of menses marks the beginning of the follicular phase, during which
follicle-stimulating hormone promotes the maturation of several ovarian follicles. After about 7 days, one
follicle dominates and development of the other follicles stops. As the dominant follicle continues to grow,
estrogen levels increase and the follicle develops luteinizing hormone (LH) receptors. The estrogen causes
proliferation of the endometrial lining, and at midcycle stimulates the pituitary gland to release a surge of
LH. This LH surge causes final maturation of the follicle and the release of the ovum into the Fallopian tube.
Release of the ovum from the follicle marks the beginning of the luteal phase. Once the follicle ruptures and
releases the ovum, the remaining cells of the follicle become the corpus luteum, which secretes large
amounts of estrogen and progesterone. Progesterone causes secretory changes to the endometrium which
are necessary for implantation. If conception occurs, the corpus luteum continues to maintain the hormone
production necessary for the early stages of pregnancy. If the ovum is not fertilized, the corpus luteum
degenerates and levels of estrogen and progesterone drop quickly. This fall in hormones causes menses
and the cycle starts over again.9
The luteal phase lasts 14 ± 2 days and is the more consistent of the 2 phases. The follicular phase can vary
by several days, making it difficult to predict when ovulation will occur. The usual menstrual cycle lasts 28
days; however, it can vary from 25–35 days.9
Once the ovum is released from the dominant follicle, it is viable (can be fertilized) for up to 24 hours. Upon
ejaculation sperm can be viable for up to 5 days, resulting in approximately 6 days when a woman is at her
most fertile.10 If pregnancy is not desired, it is important that she use an effective method of birth control,
especially during the days of her cycle she is most likely to be fertile.
Nonhormonal Contraceptive Methods

See Table 1 for a summary of the failure rates, advantages and disadvantages of each nonhormonal method of
contraception.
Natural Methods
Coitus Interruptus (Withdrawal)

Coitus interruptus is a method of contraception whereby the penis is withdrawn from the vagina before
ejaculation occurs.11 This method is an option for couples who do not want to or cannot use other
contraceptive methods. It also allows the male to participate actively in the control of conception.28
Fertility Awareness-based Methods

Fertility awareness-based methods (FABMs) of contraception are methods that rely on the physical signs
and symptoms that vary throughout a woman's menstrual cycle in response to hormonal changes.10
Women can monitor these signs and symptoms and predict when they are most likely to be fertile.
Pregnancy is prevented by abstaining from intercourse or by using another method of contraception
during the time they are most likely fertile. Natural family planning refers to the use of the FABMs as the
only method of contraception. Abstinence is practised during times of predicted fertility to prevent
pregnancy.10 Examples of some of the different types of FABMs are discussed below.
Calendar Methods
These methods require tracking days in the calendar to determine the woman's most likely fertile
days. There are 2 different ways to do this.
Calendar Rhythm Method: The woman must record the length of her cycle for 6–12 months and then
identify the length of her shortest and longest cycle. She then subtracts 18 from the length of her
shortest cycle: this number will be the earliest day that she is most likely to be fertile in her next cycle.
She then subtracts 11 from the length of her longest cycle: this number will be the latest day that she
is most likely to be fertile in her next cycle. To prevent pregnancy she must abstain from intercourse
or use another contraceptive method during her predicted fertile days. For example, if the shortest
cycle in the previous 6 months was 28 days and the longest cycle was 30 days, she would subtract 18
from 28 (=10) and 11 from 30 (=19) indicating that she is most likely to be fertile from days 10–19 of
her next cycle.
Standard Days Method: The woman begins counting on the first day of her cycle (day 1 of menses).
She is most likely to be fertile from days 8–19 and should abstain from intercourse or use another
contraceptive method during these days. The Standard Days Method should be used only by women
who have regular cycles of 26–32 days in duration. Colour-coded strands of beads, called Cycle
Beads, or smart-phone/online applications may be used to help the woman keep track of the days of
her menstrual cycle.14,29
Basal Body Temperature Method
This method is based on changes to the basal body temperature (temperature of the body at rest)
that occur during the menstrual cycle. During the follicular phase the basal temperature is stable.
There is a slight drop in basal temperature about 12–24 hours before ovulation, followed by a sharp
rise in temperature due to the progesterone secreted by the corpus luteum after ovulation. Three days
of sustained elevated temperature suggests that ovulation has likely occurred and the post-ovulation
infertile time period has started. As it is difficult to predict the start of the fertile period, some experts
suggest that women should abstain from intercourse or use another method of contraception from
day 1 of menses until the 3 days of elevated temperature have occurred.30 The basal temperature
remains elevated until menses. Basal thermometers (similar to regular thermometers but with a
wider calibration set) are required to easily distinguish the slight variations in temperature. The
temperature is taken orally, rectally or vaginally before the woman rises for the day. It should be taken
at the same time and by the same route each day. The woman should avoid speaking, eating, drinking
or smoking before taking a reading. Factors that can affect basal temperature include fever or
infection, travel, emotional changes and certain medications, e.g., hormones, corticosteroids. Digital
basal thermometers are preferred over mercury thermometers as they are easier to use and read, and
the readings are stored in memory until needed.31,32,33
Some digital basal thermometers combine data about menstrual cycle history with the measured
temperatures to provide information about the timing of fertility and can be used with smartphone or
online apps.
Cervical Mucus Methods
Cervical mucus can be used as an indicator of fertility as it changes over the course of the menstrual
cycle. Cervical mucus is almost nonexistent after menses. During the follicular phase it is opaque,
white or yellowish in colour, viscous and sticky. The mucus increases in volume and takes on the
appearance of uncooked egg whites (clear, thin and stretchable) as ovulation approaches. After
ovulation the mucus becomes opaque and viscous until menses. Changes in cervical mucus are the
result of an increase in estrogen. Around the time of ovulation, the character of the mucus provides a
favourable environment for sperm.14
There are 2 different methods of evaluating mucus. With the TwoDay Method, women look for the
presence or absence of any mucus every day and ask: 1) Did I have cervical mucus today? and 2) Did
I have cervical mucus yesterday? Answering “yes” to one or both questions (e.g., presence of mucus
the day before and/or that day) indicates fertility that day, thus the woman should abstain from
intercourse or use another method of contraception that day. With the Billings Ovulation Method, the
woman checks her cervical mucus every day after menses finishes. She should consider herself
fertile as soon as she notices any secretions. The end of the fertile period is the fourth day after the
last appearance of abundant, clear and stretchy secretions.14
Symptothermal Method
The symptothermal method of contraception uses both the changes in cervical mucus and changes
in basal temperature to determine the fertile period.31,32,33
Lactational Amenorrhea Method
Maximal suckling at the breast in women who almost exclusively breastfeed their babies provides a
natural contraceptive effect. This greatly reduces the risk of pregnancy for the first 6 months
postpartum if the baby is breastfed on demand, supplemental bottle feeding is avoided and only
minimal supplements are provided by cup or spoon. However, if menstruation has resumed,
breastfeeding is reduced, bottle feeding or food supplements are introduced, or the baby has reached
6 months of age, another method of contraception is required.15
Fertility Monitors/Ovulation Prediction Tests

Ailments—Home Testing Products: Fertility Test Kits.
Fertility monitors or ovulation prediction tests (see Pregnancy and Fertility Testing) are used by women
to help determine their fertile and infertile periods by examining urine and saliva for changes that occur
naturally throughout the menstrual cycle. Although primarily marketed for patients with infertility, these
monitors can be used by all women to obtain a better understanding of their menstrual cycles and to
help identify periods of fertility and infertility for the purpose of contraception. Devices can be purchased
from some pharmacies and various websites.
Urinary LH tests test urine for LH, alone or in combination with estrone-3–glucuonide (E3G) as the
presence of LH and E3G in the urine is indicative of a fertile period in a woman's cycle.34
Saliva microscopy consists of examining saliva for the presence of sodium chloride, which increases in
response to increasing estrogen levels, indicating a fertile period. If sodium chloride is present in dried
saliva, it will crystallize and appear as a “fern”. A sample of saliva is placed on a glass microscope slide,
dried, and inspected. Small dots indicate low fertility while small ferns and large ferns indicate
intermediate and high fertility, respectively.34
Barrier Methods
Ailments—Contraceptive Products: Male Condoms, Vaginal Barrier Devices.
Diaphragm
Figure 1: Diaphragm
A diaphragm is a small, reusable, soft silicone dome with a covered flexible spring at the outer edge that
is inserted into the vagina (see Figure 1). Proper use of the diaphragm creates a barrier at the cervix and
prevents the sperm from entering the uterus, reducing the chance of pregnancy. Traditionally, it was used
in conjunction with a spermicidal gel containing Nonoxynol-9 (N-9).17 However, there is currently no
spermicidal gel available in Canada that contains N-9. Acid-buffering gels are now available for use with
the diaphragm. These gels form a physical barrier and lower the pH, thus reducing sperm mobility (for
further information see Spermicides).35
There are currently three types of diaphragms available in Canada. The Milex Wide-Seal Arcing Style and
the Milex Wide-Seal Omniflex Style come in a variety of sizes and must be fitted for the individual woman
by a trained healthcare practitioner. Annual replacement is recommended.35,36 The Caya SILCS is
available in one size only that is designed to fit most women. It can last up to 2 years.35,37,38
The diaphragm must be inserted prior to intercourse and should stay in place for at least 6 hours after
intercourse, but it must be removed within 24 hours to reduce the risk of toxic shock syndrome. To apply
the gel, the diaphragm is held dome-side down (like a cup) and approximately one teaspoonful of gel
squeezed into the dome. A little of the gel is applied to the rim of the diaphragm with a finger. To insert
the diaphragm, it must first be folded and then inserted into the vaginal canal. The diaphragm is pushed
along the back of the vagina as far as it will go. The front rim is tucked up along the roof of the vagina
behind the pubic bone and the back rim of the diaphragm is below and behind the cervix. This is usually
done with the woman standing with one foot propped up, squatting or lying on her back. When the
diaphragm is properly in place (see Figure 1) the woman should not feel it, nor should the male partner
be aware of its presence. The tension between the diaphragm and vaginal wall holds the diaphragm in
place. The Arcing39 and Omniflex40 diaphragms also create suction with the vaginal mucosa which
provides additional action to keep them in place. If intercourse has not occurred within 2 hours of
insertion of the diaphragm, more gel should be added.35,38 An additional application of gel is required
with each repeated act of intercourse but must be applied using an applicator, without removing the
diaphragm.19,35
The diaphragm can be removed by hooking the index finger behind the front rim and pulling down and
out. Alternatively, the woman can assume a squatting position and push downward with her abdominal
muscles (bearing down as one would for a bowel movement). Once removed, it should be washed with
mild soap and water, rinsed, dried with a towel and stored in its container.19,21
Cervical Cap
Figure 2: Cervical Cap
The cervical cap is a reusable, dome-shaped device that is inserted into the vagina to fit snugly over the
cervix (see Figure 2).17 Like the diaphragm, the cervical cap is a barrier that blocks the passage of sperm
from the vagina through the cervix and was traditionally used in conjunction with a spermicidal gel. A
groove on the inside of the cap creates a seal that helps to keep the cap in place with support of the
vaginal wall.
The silicone FemCap is currently the only cervical cap available in Canada although other types have
been available in the past and may still be in use.41 The FemCap is available in 3 sizes; the correct size is
ordered not by fit but based on whether the user has ever been pregnant and/or had a vaginal delivery.
The smallest size is for women who have never been pregnant. Women who have been pregnant but not
delivered vaginally (e.g., have miscarried, terminated a pregnancy or delivered by Caesarian section) use
the medium size, while the largest one is used by those who have had vaginal delivery of a full-term baby.
The FemCap can be purchased online and should be replaced yearly.35,41
When using a cervical cap, it should be filled about one-third full with acid-buffering gel. The rim of a
cervical cap should not be covered with gel. The rim should be squeezed between the thumb and
forefinger and the cap inserted into the vagina. The cap is pushed as deep into the vagina as possible.
Suction is produced by pressing on the dome and twisting the cap like the lid on a jar. Proper fitting is
verified by running a finger along the rim and firmly tugging down on the dome. The cap should remain in
place and there should be a sensation of the cervix being pulled. While not a concern with the FemCap
as it is made of silicone, oil-based products (e.g., Vaseline) are not recommended if a vaginal lubricant is
required when using a latex cervical cap as they can decrease the integrity of the latex. Additional gel
may be inserted if repeat intercourse occurs; however, this should be done without removing the cap.
To remove it, the cap is tilted to one side and a finger is hooked under the rim to pull it out. The cap
should be left in place for at least 8 hours after intercourse; it should be worn for no longer than 48 hours
at a time. Once removed, the cap is washed with mild soap and warm water.21
Contraceptive Sponge
Figure 3: Contraceptive Sponge
Contraceptive single-use sponges, pieces of soft foam filled with spermicide, have been available in
Canada on and off for a number of years (see Figure 3). Sponges are inserted into the vagina so that they
cover the cervix. They function by 2 mechanisms: as a physical barrier by blocking the entrance to the
uterus and by spermicidal activity.
Perhaps the most well known is the Today Sponge (containing nonoxynol-9), discontinued in the early
1990s but reintroduced in Canada in 2011 and available in some pharmacies.
The Today Sponge is available in 1 size only. It can be inserted at any time before sexual intercourse and
must be kept in place for at least 6 hours after the last act of intercourse. It provides contraceptive
protection for 24 hours no matter how many times intercourse occurs. If intercourse occurs when the
sponge has been in place for 24 hours, the sponge should not be removed for 6 hours. Thus, the
maximum length of insertion for the sponge is 30 hours. Leaving the sponge in longer than 30 hours
increases the risk of vaginal irritation and infections. The Today Sponge has a woven polyester loop on
one side that aids in removal. Once removed, the sponge should be discarded.42
Female Condom
Figure 4: Female Condom
The female condom (branded as FC2) is a single-use barrier contraceptive that protects against
pregnancy as well as against HIV and other STI transmission (see Figure 4). FC2 replaces the first-
generation polyurethane female condom sold under the brand name Reality. The second-generation
female condom is made from nitrile (a synthetic rubber). The new condom performs as effectively as the
original polyurethane condom.43 The female condom is a pouch coated with a silicone-based
nonspermicidal lubricant with rings at each end to help keep the condom in place within the vagina. The
closed end is inserted into the vagina and covers the cervix. The ring on this end helps anchor it in place
like a diaphragm. The open end hangs out of the vagina. The ring on the open end is placed against the
body and helps prevent the condom from entering the vagina. Inserting the condom a few minutes
before intercourse and/or adding extra lubricant may reduce the noise, but it can be inserted up to 8
hours prior to intercourse.35 After intercourse the condom should be twisted to seal in the semen and
then gently removed and discarded. A new condom must be used for repeated intercourse.17
Male Condom
Figure 5: Male Condom
The history of condoms goes back to medieval times when sheaths of linen or animal intestine were
used as contraceptives. Today the single-use condom is a sheath of processed lamb cecum (“lambskin”),
latex, polyisoprene or polyurethane that fits over an erect penis (see Figure 5). It provides a receptacle
that prevents semen from reaching the vagina and cervix. The use of latex condoms as a component of
“safer sex” is widely publicized and encouraged as a means of reducing the risk of transmission of STIs,
including HIV.24
Theoretically, condoms should be completely effective in preventing pregnancy, but in reality they are not.
Condom failure may be attributed to either breakage or slippage. The incidence of breakage has been
reported to be between 0.5% and 2.5%, and that of slippage between 0.6% and 2%.44,45,46,47
Risk factors associated with breakage and/or slippage include opening the package with sharp objects,
unrolling condoms before putting them on, lack of sex education or experience in using condoms and
lengthy or intense intercourse.44,45,46,47,48 The use of lubricants has been associated with increased
slippage in vaginal intercourse and reduced slippage in anal intercourse.44 Alcohol and drugs are also
associated with an increased incidence of condom failure (both breakage and slippage).44,45,46,47,48
Some of these risks may be attenuated by providing appropriate counselling.
Other risk factors for breakage and/or slippage include low income and low education of the user as well
as a larger penile circumference.44,45,46,47,48
The other leading cause of condom failure relates to user attitudes that lead to inconsistent use, e.g.,
reduction in physical sensations, uncomfortable feeling, interruption in sexual activity, perception that
sexual activity must be less vigorous, fear of sending a message that either the user or partner is
unclean.
Condoms should not be used after the expiry date on the product packaging. They should be kept in a
cool, dry place, out of the sunlight. Condoms should not be disposed of in the toilet after use; they should
be wrapped in tissue and disposed of in the garbage.24
Latex condoms are made from natural rubber latex. Laboratory studies reveal that they are an effective
physical barrier to microorganisms such as those causing HIV and other STIs. Latex condoms are
available with a variety of features: reservoir end, lubricated (wet or dry), lubricated with spermicide
(nonoxynol-9), thin latex, extra strength, tapered, contoured, ribbed, studded, textured internal surface,
coloured and flavoured. Most are produced in a standard size although smaller and larger sizes are also
available.24
A 2008 review concluded that latex condoms provide considerable protection against the transmission
of STIs that spread primarily through infected secretions (HIV, gonorrhea, chlamydia and
trichomoniasis).49 Only partial protection is afforded by condoms against infections transmitted through
skin or mucous membrane (herpes simplex, human papillomavirus).49 A 2009 meta-analysis produced a
similar conclusion, reporting that using a condom provided only moderate protection against
transmission of herpes simplex virus 2 (HSV-2).50
Oil-based lubricants (e.g., massage oil, Vaseline) should never be used with latex condoms as they cause
the latex to deteriorate. Water-based lubricants (e.g., Astroglide, K-Y Jelly) will not cause latex condoms
to break down and therefore are safe to use. Latex condoms are more elastic than lambskin and as a
result are more likely to remain in place on the penis during intercourse and on withdrawal.
An estimated 1–6% of the American population is allergic to latex. Repeated exposure to certain proteins
in the latex is thought to be the cause of allergies. The most common symptom for both men and
women is genital inflammation with redness, itching and burning. In more severe cases, intraepidermal
edema leads to the formation of vesicles. Once the vesicles rupture, the skin weeps, oozes and crusts.
An old recommendation to manage latex allergy advised couples to use a lambskin condom in
conjunction with a latex condom for contraception and STI protection. If the woman was allergic, a
lambskin condom was worn over a latex condom; if the man was allergic, a lambskin condom was worn
under the latex condom.51 The current recommendation is to use polyurethane or polyisoprene male
condoms, or nitrile female condoms, in place of latex condoms.24,35,52
Lambskin condoms are made from the intestinal cecum of lambs and may be referred to as “natural
skin,” “natural membrane” or “lambskin” condoms. Elasticity is poor and they may slip off the penis
during intercourse or on withdrawal. Oil- or water-based lubricants or vaginal medications can be used
with these condoms. It is claimed that they provide better transmission of body heat and therefore
greater sensitivity than latex condoms. Lambskin condoms do not provide the same level of protection
against HIV or other STI transmission as latex condoms because they have small pores that allow
passage of the microorganisms. Lambskin condoms should be avoided by those who have allergies to
lanolin or wool.24
Polyurethane condoms are latex-free and are stronger than latex so the condoms are thinner, allowing for
greater sensation. Unlike latex condoms, either oil- or water-based lubricants or vaginal medications can
be used with polyurethane condoms. However, they are not as stretchy as latex, so breakage and
slippage rates are higher.53 Polyurethane condoms have similar efficacy to latex condoms with regard to
preventing pregnancy. Effectiveness for STI prevention has not been well studied; however, they are
believed to offer the same level of protection against HIV and other STI transmission as latex
condoms.24
Polyisoprene condoms are made from a synthetic rubber that is chemically the same as latex, except
that the proteins causing latex allergy have been removed. Only water-based lubricants or vaginal
medications should be used with these condoms, as oil-based products may reduce the integrity of the
condoms. Polyisoprene condoms effectively prevent both pregnancy and HIV or other STI
transmission.53 They are considered to be as strong and safe as latex condoms. Compared with
polyurethane, polyisoprene is softer, more form-fitting, thicker, more resistant to breakage and allows
more stretch.53,54
Spermicides
Ailments—Contraceptive Products: Spermicidal Products and Devices.
Spermicides are products that are inserted vaginally and contain chemicals that kill or immobilize sperm.
Traditionally, commercially available products have contained the surfactant nonoxynol-9 (N-9); however,
only a few products containing N-9 remain on the market in Canada. N-9 makes sperm unviable by making
the sperm cell membranes permeable to moisture, resulting in swelling and destruction of the
membranes.19,55 Spermicides containing N-9 were available in various dosage forms and could be used
alone or in combination with condoms, cervical caps, diaphragms or intrauterine devices. Sponges and films
containing spermicide also act as physical barriers in preventing conception.
Spermicidal agents containing N-9 were once believed to reduce the transmission of HIV and other STIs;56
however, this is now refuted. Frequent use of N-9 can cause irritation and lesions to genital mucosa, which is
thought to increase the risk of transmission of infections.55,57 The World Health Organization (WHO) and
the Contraceptive Research and Development (CONRAD) Program in the United States reviewed the
evidence in 2001 and concluded that N-9 does not protect against the transmission of HIV, gonorrhea,
trichomonas, chlamydia, bacterial vaginosis or candidiasis.58
Current recommendations include:

N-9 should not be used for the prevention of HIV or other STIs
women who have multiple acts of intercourse daily should not use N-9 products
spermicide-coated condoms should not be recommended; however, condoms lubricated with N-9 can
be used if the alternative is no condom at all
the benefits and risks of use of N-9 should be evaluated before using it for contraception.59
Due to concerns regarding N-9 there is now more interest in other spermicidal agents. In some countries
other surfactants such as octoxynol, menfegol and benzalkonium chloride are used in spermicidal
products.21 Contragel green is a jelly produced in Germany by Kessel-Marketing GmbH and distributed in
Canada as an acid-buffering barrier gel. It contains a combination of ingredients including lactic acid,
sodium lactate, methylcellulose and sorbic acid. Caya Diaphragm Gel, similar to Contragel, is also approved
for sale in Canada as an acid-buffering barrier gel. The methylcellulose forms a physical barrier while some
evidence suggests that lactic acid reduces the pH of the vagina, limiting sperm motility.60,61 These gels are
not intended to be used alone but rather in combination with barrier methods such as diaphragms and
cervical caps.62
Spermicidal foam and film containing N-9 are currently available in Canadian pharmacies. Advise women
using contraceptive foam to mix the product well by shaking the container about 20 times before use and to
follow the directions on the package insert regarding the amount required. While the woman is lying down,
the applicator is inserted into the vagina as deeply as possible, then the plunger is pushed to release the
dose. Intercourse should take place within the prescribed time for the particular product being used (usually
30–60 minutes after insertion). More foam should be inserted if more than the prescribed time has passed
since the first dose was inserted, and for every time the couple engages in intercourse.21 After intercourse
any residual spermicide should not be removed (e.g., by douching) for at least 6 hours.17 Contraceptive
foams may be used alone or in combination with a barrier method.21
VCF, a vaginal contraceptive film, is manufactured by Apothecus Pharmaceutical Corp. and contains N-9 in
a film base.63,64 VCF dissolves completely and quickly into a gel after insertion high into the vagina against
the cervix. It can be inserted from 15 minutes to 3 hours before intercourse. If more than 3 hours have
elapsed without intercourse, or intercourse is repeated, another film should be inserted.65 The gel acts as a
barrier to block sperm from entering the cervix and the N-9 is spermicidal. To insert the film, the VCF is
removed from the packaging, folded in half, placed on the tip of the second or third finger and then inserted
into the vagina and applied against the cervix. Women do not need to douche after intercourse as the gel will
disappear on its own. However, if douching is desired, the woman should wait at least 6 hours after
intercourse to avoid washing away spermicide too early.17 Contraceptive films may be used alone or in
combination with a barrier method.21
Copper Intrauterine Device

Copper Intrauterine Device
Figure 6: Intrauterine Device
The copper intrauterine device (IUD) is a small T-shaped device that is inserted into the uterus to prevent
pregnancy (see Figure 6).66,67 Though the precise mechanism of action of the IUD is unknown, it is generally
accepted that copper IUDs impede the ascent of sperm to the Fallopian tubes or reduce the ability of sperm
to fertilize an ovum. A foreign body reaction to the IUD in the uterus causes both cellular and biochemical
changes that may be toxic to sperm. Sperm function is impaired by the increase in copper ions, enzymes,
prostaglandins and white blood cells in the fluid in the uterus and Fallopian tubes.68 Copper IUDs must be
inserted by a trained healthcare practitioner and should be replaced based on the manufacturer's
recommendation (e.g., 30 months to 10 years).27,69,70 A long-acting reversible method of contraception,
such as a copper IUD, is preferred in young women at high risk of contraceptive failure due to incorrect or
inconsistent use.71,72,73 [Evidence: SORT B] An alternative method of long-acting reversible contraception
for this patient population is a levonorgestrel intrauterine system (See Progestogen-only Contraceptives).
Intrauterine contraception is as effective as permanent methods of birth control (tubal ligation or
vasectomy) and can be considered as a first line option for both nulliparous and multiparous women.74
Table 1: Nonhormonal Contraception Failure Rates, Advantages and Disadvantages

Failure
with
Correct Failure
and with
Consistent Typical
Method Use Use Advantages Disadvantages
Withdrawal11 4% 22% No cost Correct and

No device or consistent use
medication may be
required challenging and
No HCP ejaculate could be
interaction deposited in the
required vagina if penis is
not withdrawn in
No potential
time
adverse effects
No protection
Always
from HIV or other
available
STI transmission
Failure
with
Correct Failure
and with
Consistent Typical
Fertility awareness– No Continuous

based methods pharmacologic charting and
(FABMs),10,11,13,14,15 agent required monitoring
No HCP required
interaction Several months
required may be required to
No potential gain
adverse effects understanding of
Women's fertility signs and
knowledge of symptoms
menstrual cycle Abstinence or
is increased and another method of
can be used to contraception
determine must be used
fertile period to consistently
aid conception during fertile
if desired period
May be Ovulation may
supported by occur outside the
religious calculated fertile
organizations times
No protection
from HIV or other
STI transmission
Failure
with
Correct Failure
and with
Consistent Typical
Rhythm 0.1–9% 25% No Continuous

pharmacologic charting and
agent required monitoring
No HCP required
No potential gain
if desired period
organizations times
No protection
No cost from HIV or other
No device or STI transmission
medication
required Difficult to predict
fertile days if
cycles are
irregular
Failure
with
Correct Failure
and with
Consistent Typical
Standard days 4.8–5% 8–25% No Continuous

No HCP required
No potential gain
if desired period
organizations times
No protection
Aids such as from HIV or other
cycle beads STI transmission
only possible
device required Difficult to predict
fertile days if
cycles are
irregular
Failure
with
Correct Failure
and with
Consistent Typical
Basal body 1% No data No Continuous

temperature for pharmacologic charting and
typical agent required monitoring
use No HCP required
No potential gain
if desired period
organizations times
No protection
Thermometer from HIV or other
only device STI transmission
required
Temperature may
be affected by
illness, infection
or jet lag
Failure
with
Correct Failure
and with
Consistent Typical
TwoDay 4% 14% No Continuous

No HCP required
No potential gain
if desired period
organizations times
No protection
medication
required Secretions may be
altered by
douching, semen,
lubricants or
vaginal infections
Failure
with
Correct Failure
and with
Consistent Typical
Billings ovulation 0.5–3% 3– No Continuous

22.3% pharmacologic charting and
No HCP required
No potential gain
if desired period
organizations times
No protection
medication
required Secretions may be
altered by
douching, semen,
lubricants or
vaginal infections
Failure
with
Correct Failure
and with
Consistent Typical
Symptothermal 0.3% 0.2– No Continuous

20% pharmacologic charting and
No HCP required
No potential gain
if desired period
organizations times
No protection
Thermometer from HIV or other
only device STI transmission
required
Temperature may
be affected by
illness, infection
or jet lag
Secretions may be
altered by
douching, semen,
lubricants or
vaginal infections
Failure
with
Correct Failure
and with
Consistent Typical
Lactational 0–8% No data No No protection

amenorrhea for pharmacologic from HIV or other
typical agent required STI transmission
use No HCP Must breastfeed
interaction baby on demand,
required avoid any bottle
No potential feeds and provide
adverse effects only minimal
May be supplemental
supported by food
religious
organizations
No cost
No device or
medication
required
Fertility 5.3–8.3% No data No Continuous

monitors/ovulation for pharmacologic charting and
prediction tests14,16 typical agent required monitoring
use No HCP required
No potential gain
if desired period
Ovulation may
occur outside the
calculated fertile
times
No protection
from HIV or other
STI transmission
Cost
Failure
with
Correct Failure
and with
Consistent Typical
Diaphragm17,18 6% 16% Provides May be difficult to

immediate insert and/or
protection remove
Ability to insert May be dislodged
in advance to during intercourse
avoid interfering Not proven to
with sexual protect against
encounter HIV or other STI
Ability to leave transmission
in place up to 24 May increase the
h risk of TSS
Fitted diaphragms
require refitting
after childbirth or
weight change (5-
10 kg)
Use of N-9
spermicides with
a diaphragm may
increase risk of
UTI
Cervical cap17 9% in 20% in Provides May be difficult to

women women immediate insert and/or
who have who protection removec
not given have Ability to insert May be dislodged
birth not in advance to during intercourse
26% in given avoid interfering
birth No protection
women with sexual
from HIV or other
who have 40% in encounter
STI transmission
given birth women Ability to leave
May increase the
who in place up to 48
risk of TSS
have h, allowing
given spontaneous Not as effective in
intercourse women who have
birthb had a vaginal birth
Requires less
acid-buffering Not suitable for
gel than a every woman as
diaphragm size, shape and
position of cervix
determine proper
fit
Unpleasant odour
may occur if used
for longer than 48
h
Failure
with
Correct Failure
and with
Consistent Typical
Contraceptive 9% in 20% in Provides May be difficult to

sponge17,21,22 women women immediate insert and/or
who have who protection remove
not given have Ability to insert No protection
birth not in advance to from HIV or other
20% in given avoid interfering STI transmission
women birth with sexual May increase the
who have 40% in encounter risk of TSS; should
given birth women Offers not be used in
who protection for women with
have 24 h even with history TSS
given repeated May produce a
birth intercourse vaginal discharge,
Small, itching or odor
comfortable, Should not be
easy to carry used during
No HCP menses
interaction N-9 in the sponge
required may increase risk
of UTI
Failure
with
Correct Failure
and with
Consistent Typical
Female condom17,23 5% 21% Provides May be difficult to

immediate learn to use
protection correctly
Ability to insert Part of the
up to 8 h in condom hangs
advance to outside the vagina
avoid interfering The condom
with sexual makes noise
encounter during intercourse
Offers Should not be
protection used concurrently
against HIV and with male
other STI condoms as they
transmission may stick together
May be used and result in
with oil- or slippage or
water-based breakage
lubricants as
not latex based
May be used
during menses
May be used in
women with
history TSS or
UTI
May be used in
latex-allergic
individuals
No HCP
interaction
required
Failure
with
Correct Failure
and with
Consistent Typical
Male condom24 2% 18% Inexpensive May be difficult to

Convenient to put on correctly
obtain and may not stay
Easy to use and in place
carry May break or slip
Provides and decrease
immediate effectiveness
protection May negatively
Offers affect sexual
protection encounters
against HIV and through
other STI embarrassment,
transmission interruption to put
(latex, on, inability to
polyisoprene maintain an
and erection, reduced
polyurethane sensation, and
varieties only) need for prompt
withdrawal after
No HCP
intercourse
interaction
required
N-9 spermicides 18% 29% Easy to use and May negatively

(alone)17,19,25 carry affect sexual
Provides encounters as
immediate repeated
protection application is
No HCP required before
interaction each act of
required intercourse
Do not cause Messy, may have
systemic unpleasant odour
effects and/or taste
May irritate vagina
and/or penis
No protection
from HIV or other
STI transmission.
May increase the
risk of HIV
transmission.
Use with a
diaphragm may
increase risk of
UTI
Failure
with
Correct Failure
and with
Consistent Typical
Copper IUD19,26,27 0.6% 0.8% Provides No protection

protection from from HIV or other
30 months up to STI transmission
10 y (depending Trained HCP
on device) required to insert
No interference and remove the
with sexual IUD
encounters Initial cost may be
high, although
may be cost-
effective over time
May cause
periods to become
heavier or
menstrual cramps
to increase
Complications are
rare but may
include irregular
bleeding or
spotting, infection,
perforation of the
uterus or
expulsion
a Determining failure rates with FABMs has proven to be difficult as the published studies have serious
methodological limitations (such as high discontinuation rates and excluding data during the learning phase which
results in favoring the method being studied).10,12 Despite these limitations, reviews10,13 report the percentages of
unintended pregnancy as presented here.
b A Cochrane review concluded that the FemCap was not as effective as a diaphragm in preventing pregnancy.20
c Cervical caps may be more difficult to insert than a diaphragm.
Abbreviations: HCP = healthcare practitioner; IUD = intrauterine device; N-9 = nonoxynol-9; STI = sexually transmitted
infection; TSS = toxic shock syndrome; UTI = urinary tract infection
.....
Hormonal Contraceptive Methods
For more information on hormonal contraceptive therapy, consult the Compendium of Therapeutic Choices: Contraception.
Estrogen and Progestogen Combinations

Products containing combinations of estrogen and progestogen work primarily by inhibiting ovulation.75,76
Other mechanisms that may contribute to the action of combined products include thickening of the cervical
mucus which impedes sperm from entering the cervix, interference with fertilization by altering tubal motility
of the ovum, and inflammation and atrophy of the endometrial lining.75
Combination oral contraceptive pills (COCs) contain varying amounts of ethinyl estradiol and different
amounts and types of progestogens. Many brand-name and generic options are available. The pills are
usually taken in a cyclical manner: active pills are taken for 21 days followed by a 7-day hormone-free
interval. The hormone-free interval consists of placebo pills, or no pills at all. COCs that have a shortened
pill-free interval (4 days) and extended cycles (pill-free intervals every 84 days) are also available. Failure
rates range from 0.3% when used correctly and consistently, to 9% with typical use.77 COCs may also be
given continuously (no pill-free days).78
The transdermal contraceptive patch (Evra) contains ethinyl estradiol and the progestogen norelgestromin.
It is applied in a cyclical manner: one patch is applied once weekly for 3 weeks followed by a 1-week
hormone-free interval. Failure rates range from 0.3% when used correctly and consistently, to 9% with typical
use.77 Patches may also be administered continuously (no hormone-free days).78
The vaginal contraceptive ring (NuvaRing) contains ethinyl estradiol and the progestogen etonorgestrel. It is
also used in a cyclical manner: one ring inserted into the vagina and left in place for 3 weeks, followed by a
1-week hormone-free interval. Failure rates range from 0.3% when used correctly and consistently, to 9% with
typical use.77 Vaginal rings may also be administered continuously (no hormone-free days).78
Progestogen-only Contraceptives
The progestogen-only pill or mini-pill (Micronor) contains norethindrone; it works primarily by causing
changes to the cervical mucus making it less hospitable to sperm.76 The progestogen-only pill is taken daily
with no hormone-free interval. As the mechanism of action is time-dependent, it is important that the
progestogen-only pill be taken at the same time each day; a delay greater than 3 hours is considered a
missed pill. Failure rates range from 0.3% when used correctly and consistently, to 9% with typical use.77
Depot medroxyprogesterone acetate (DMPA) injection (Depo-Provera) contains medroxyprogesterone

acetate which is absorbed slowly from the injection site. The primary mechanism of action of DMPA is to
suppress ovulation.76 It is injected intramuscularly every 12–13 weeks. Failure rates range from 0.2% when
used correctly and consistently, to 6% with typical use.77
The levonorgestrel intrauterine system (LNG-IUS) contains levonorgestrel on a vertical stem. Like the
copper IUD it offers the same “foreign body” mechanism of action plus the levonorgestrel causes thickening
of the cervical mucus, an antiproliferative effect on the endometrium and possible suppression of ovulation
in some women. There are 3 products available in Canada. The Mirena IUS releases LNG 20 μg/day and
should be replaced every 5 years.79 The Jaydess IUS releases LNG 6 μg/day and should be replaced every 3
years.80 The Kyleena IUS releases 17.5 μg/day and should be replaced every 5 years.81 Failure rates ranged
from 0–1.2% for Mirena,79 0.4–0.9% for Jaydess80 and 0.2–1.4% for Kyleena.81 Both Jaydess and Kyleena
have a smaller and narrower insertion tube than Mirena and therefore they may be an option for women with
small and/or narrow uterine cavities. Long-acting reversible contraception such as a levonorgestrel IUS is
preferred in young women at high risk of contraceptive failure due to incorrect or inconsistent use.71,72,73
.....
Emergency Contraception
Introduction
For more information on emergency contraception, consult the Compendium of Therapeutic Choices:
Contraception.
Table 4 lists selected products for emergency contraception.
Ailments—Contraceptive Products: Emergency Contraceptives.
Emergency contraception (EC) is a means of avoiding unplanned pregnancies. EC must be used after having
unprotected sex but before implantation occurs. It offers no protection against HIV or other STI
transmission. EC is meant to be used after an isolated act of intercourse and should not be relied upon as a
routine method of contraception because it is not as effective as contraceptives used on a regular basis.
Examples of situations that warrant EC include unprotected intercourse, a broken condom, displacement of
a diaphragm or cervical cap during intercourse, sexual assault, missed doses of regular birth control or other
errors in the use of a regular contraceptive method.87
Methods of EC include the use of hormones or IUDs. Hormonal methods are the most commonly used.
Levonorgestrel is the progestogen-only method. Estrogen/progestogen combinations are also known as the
Yuzpe method. Ulipristal is an anti-progestogen used for EC.88,89
Hormonal EC is normally used within 72 hours of unprotected intercourse and is more effective the earlier it
is used. There is some evidence that hormonal EC may be somewhat effective beyond the 72-hour period,
up to 5 days after intercourse. Insertion of an IUD can be used as a method of EC up to 7 days after
unprotected intercourse.84,88
A Cochrane review concluded that ulipristal was marginally more effective than levonorgestrel, and
levonorgestrel was more effective than the Yuzpe method. The copper IUD was noted as being the most
effective EC method, offering the added benefit of providing ongoing contraception.90
Copper Intrauterine Device (IUD)

The postcoital insertion of a copper IUD is a highly effective means of EC.91 To avoid the risk of use after
implantation, insertion within 5 days of unprotected intercourse was typically recommended.92 However,
evidence suggests that the copper IUD is effective if inserted within 2–10 days of unprotected
intercourse.84,88,92 The 2015 Canadian Contraception Consensus by the Society of Obstetricians and
Gynaecologists of Canada (SOGC) recommends copper IUDs be used for EC up to 7 days after unprotected
intercourse, provided pregnancy has been ruled out and there are no other contraindications to use.35
Another benefit of the use of a copper IUD for EC is that it can be left in place and used as an effective
contraceptive method for the life of the device. Obtaining an IUD for this indication is not as easy as the
Yuzpe or levonorgestrel options. Insertion of an IUD requires a trained professional and a pelvic
examination.
Mechanism of Action
The popularity of the copper IUD as a choice for EC may have been negatively affected due to the belief
that IUDs function as an abortifacient.93 This is based on one of the proposed mechanisms of action:
that IUDs function by preventing implantation of a fertilized ovum. A scientific statement from the WHO
argued that it was unlikely that the efficacy of IUDs was based mainly or exclusively on their ability to
interfere with implantation.94 They added that IUDs most likely interfere with steps in the reproductive
process that occur before fertilization of the ovum, e.g., direct toxic effect on the sperm. After reviewing
the available evidence, the American College of Obstetricians and Gynecologists also concluded that
IUDs do not function as an abortifacient.95
Efficacy
The copper IUD is a highly effective means of EC, reducing the risk of pregnancy by 99%.84
Adverse Effects
IUDs can cause vaginal bleeding and uterine cramping. Insertion of the IUD can be painful.84
Progestogen-only (Levonorgestrel)
Mechanism of Action
The precise mechanism of action of LNG in EC has not been clearly elucidated but is believed to be
multifactorial. If LNG is given in the first half of the menstrual cycle it will prevent or postpone
ovulation.87 The progestogen also causes thickening of the cervical mucus, which will alter sperm
mobility and migration. LNG may interfere with implantation by altering the endometrium but data are
conflicting. It has also been suggested that LNG alters Fallopian tube motility but currently no data
support this suggestion. The mechanism of action is likely a combination of the above, and may depend
somewhat on when LNG is given in relation to the time of unprotected intercourse and the phase of the
menstrual cycle. LNG has no effect on an existing pregnancy.87
Efficacy
Several studies have evaluated the efficacy of LNG as a method of emergency contraception. Eight
studies including over 9500 women reported a reduction in rate of pregnancies ranging from 59–94%.84
In one of the largest multicentre comparative clinical trials (including almost 2000 women), the LNG
method produced a slightly better response than the Yuzpe method.82 Pregnancy rates were 3.2% and
1.1% with the Yuzpe and LNG methods, respectively. Efficacy was highly dependent on the timing of the
first dose relative to the time of unprotected intercourse. If the first dose was given within 24 hours,
pregnancy rates were 2% and 0.4% for Yuzpe and LNG, respectively. At 25–48 hours post-intercourse,
pregnancy rates rose to 4.1% and 1.2%, and at 49–72 hours to 4.7% and 2.2% respectively.
The efficacy of levonorgestrel may be reduced with increased body weight or BMI.96 In March 2014,
Health Canada issued an advisory to inform women and healthcare practitioners that levonorgestrel
emergency contraceptives are less effective in women weighing 75–80 kg and ineffective in women
weighing more than 80 kg.85 In May 2014, SOGC responded to Health Canada's advisory and concluded
that, until further evidence is available, women who do not have access to or do not wish to use
alternative emergency contraceptive methods (such as copper IUDs) should not be discouraged from
using levonorgestrel-only emergency contraception as it may still provide some benefit.86 The European
Medicines Agency completed an extensive review and recommends that emergency contraceptives
containing levonorgestrel continue to be used irrespective of body weight as the benefits outweigh the
risks.97,98
Adverse Effects
There is a lower incidence of adverse effects reported with the levonorgestrel regimen compared with
the Yuzpe method. In a comparative trial, adverse effects of the levonorgestrel and Yuzpe groups were
nausea (23.1% vs. 50.5%), vomiting (5.6% vs. 18.8%), dizziness (11.2% vs. 16.7%), fatigue (16.9% vs.
28.5%), headache (16.8% vs. 20.2%), breast tenderness (10.8% vs. 12.1%) and lower abdominal pain
(17.6% vs. 20.9%).82 If vomiting occurs within 2 hours of administration, some practitioners recommend
the dose be repeated.89
Irregular spotting and breakthrough bleeding have been reported in studies as ranging in incidence from
3–37%.83 Menses should occur within 1 week of the normally expected time after administration of LNG.
If menses does not occur, the woman should be assessed for possible pregnancy.87
Despite levonorgestrel not being recognized as a major teratogen, pregnancy is still considered a
contraindication to its use for EC. Levonorgestrel has no known adverse effects on clotting factors, so its
use in women with a history of thromboembolism and migraine with aura is safer than the Yuzpe
method.99
Administration and Instructions for Use

LNG is packaged both as a single 1.5 mg tablet and as two 0.75 mg tablets, to be taken together to make
a 1.5 mg dose. The tablets (1 or 2 depending on the product) should be taken as soon as possible (within
72 hours) after unprotected intercourse.100 As noted previously, LNG may be taken up to 120 hours after
unprotected intercourse although the efficacy will be lower than when it is taken earlier.84 Women should
be advised of the common adverse effects. If menses does not occur within 3 weeks of the dose, assess
for possible pregnancy. Administration of LNG will not protect against future acts of unprotected
intercourse. Therefore, her customary method of contraception should be resumed (see Table 2).
Alternatively, she may abstain from sex or use backup contraception until menses occurs, then restart
contraception after the next menstrual period starts as per usual “start” instructions; she should continue
to abstain from sex or use backup contraception until the method is effective. Women may be referred
as needed to an appropriate healthcare practitioner for additional counseling regarding ongoing
contraceptive methods and/or STI services.
84,101
Table 2: Resumption of Contraception After Emergency Contraception (EC)
Contraceptive When to Resume
Method
Barrier methods With next sexual intercourse.
Combination Initiate new pack/product 1 day after EC. Abstain from sex or use
hormonal methods backup contraception for 7 days until the method is effective.
(oral, patch, ring)
Medroxyprogesterone Perform a pregnancy test the day after EC to rule out a pre-existing
acetate injection pregnancy. If negative, inject DMPA and abstain from sex or use
(DMPA) backup contraception for 7 days. Repeat pregnancy test 2–3 wk after
injection.
Progestin-only pill Continue the day after EC. Abstain from sex or use backup
contraception for 48 h.
Copper intrauterine Insert after start of next menses. Abstain from sex or use backup
device contraception before IUD is inserted and, once inserted, until it is
effective as per manufacturer's recommendation.
Levonorgestrel Insert the day after EC. Abstain from sex or use backup contraception
intrauterine system for 7 days until the method is effective.
Estrogen-progestogen Combinations
The use of an estrogen/progestogen combination for emergency contraception was first described by Yuzpe
et al. in 1974.102 Various brands of oral contraceptives can be used to obtain the correct dose of hormones
(see Table 3). As this method is less effective and has more side effects than levonorgestrel or ulipristal,
SOGC recommends that it be used only when other methods are not available.103
Table 3: Examples of Estrogen/Progestogen Combinations for Emergency Contraception
Brand Name Estrogen Progestin 1st Dose 2nd Dose

ethinyl estradiol 20 levonorgestrel 100
Alesse µg µg 5 tablets po 5 tablets po
Brand Name Estrogen Progestin 1st Dose 2nd Dose
ethinyl estradiol 30 levonorgestrel 150
MinOvral µg µg 4 tablets po 4 tablets po
ethinyl estradiol 30 levonorgestrel 125 4 yellow

Triquilar µg µg 4 yellow tablets po tablets po
Mechanism of Action
Several possible mechanisms of action have been proposed for the Yuzpe method. These mechanisms
depend on the point in the menstrual cycle at which the hormones are administered. EC will either delay
ovulation, or result in anovulation if taken before ovulation occurs.88 The progestogen component will
also cause thickening of the cervical mucus.87
Efficacy
Failure rates reported in trials using the Yuzpe method have ranged from 0.2–7.4%.104 A meta-analysis
of 8 studies estimated that the Yuzpe method probably prevented 74% of pregnancies.105 The efficacy of
the Yuzpe method is higher when taken closer to the time of unprotected intercourse and decreases over
time. A WHO Task Force study showed that delaying the first dose of the Yuzpe method from 12–24
hours after intercourse increased the risk of pregnancy by up to 50%.104
Adverse Effects
Nausea (50%) and vomiting (20%) are the most commonly reported adverse effects of the Yuzpe
method.84 For this reason, the use of an antinauseant (e.g., dimenhydrinate) 1 hour before the hormone
doses is recommended. If vomiting occurs up to 2 hours after administration of the hormone dose, some
practitioners recommend that the dose be repeated.84
Other possible side effects include headache, dizziness, fatigue, mood changes, menstrual irregularities,
vaginal bleeding and abdominal pain.91
Regular menses should occur on the expected day, but the Yuzpe method can delay menses by a few
days. Approximately 11.5% of women experience a delay of greater than 3 days beyond expected
menses.106
Pregnancy is the only contraindication to the Yuzpe method; past history of thromboembolism and
migraine with aura are relative contraindications.105,107 Pregnancy itself probably poses a far greater
risk of thromboembolism to women with a previous history of embolic events than the Yuzpe method.91
The risk of thromboembolism due to pregnancy in this population has been estimated to be 60 per 100
000 women.91 The risk of thromboembolism due to the Yuzpe method is unknown, but 3 cases of
venous thromboembolism have been reported in the United Kingdom after approximately 4 million
uses.107

The first dose of the Yuzpe method (4–5 tablets, depending on the oral contraceptive product being used
—see Table 3) should be taken as soon as possible (within 72 hours) after unprotected intercourse. As
noted previously, this method may be used up to 120 hours after unprotected intercourse although the
efficacy will be lower. The second dose of the Yuzpe method should be given 12 hours after the first
dose.84 If menses does not occur within 3 weeks of the dose, assess for possible pregnancy.
Administration of the EC will not protect against future acts of unprotected intercourse. Therefore, a
woman should abstain from intercourse or use a method of contraception until her next menses occurs.
Her customary method of contraception may be resumed as per the suggestions in Table 2. Women may
be referred as needed to an appropriate healthcare practitioner for additional counselling regarding
ongoing contraceptive methods and/or STI services.
Ulipristal
In 2015, ulipristal acetate 30 mg was approved in Canada for prevention of pregnancy when taken within 120
hours (5 days) of unprotected intercourse or known or suspected contraceptive failure.108
Mechanism of Action
Ulipristal is a selective progesterone receptor modulator that prevents progesterone from occupying its
receptor by competitive inhibition. The primary mechanism of action for emergency contraception is
believed to be inhibition or delay of ovulation.
Efficacy
Two multicenter clinical trials found ulipristal significantly reduced the risk of pregnancy after
unprotected intercourse from an estimated expected rate of 5.5% to observed rates of 2.1% and 1.78%.
Pregnancy rates did not rise significantly when ulipristal was taken later (up to 120 hours after
unprotected intercourse) compared with immediately after.109
As with levonorgestrel, the efficacy of ulipristal may be reduced with increased body weight or BMI. A
subgroup analysis of pooled data from the two phase III clinical trials shows no significant reduction in
observed pregnancy rate compared with the expected pregnancy rate for women with a BMI >30 kg/m2
and an extensive review by the European Medicines Agency (EMA) determined there are limited and
inconclusive data on the effect of high body weight/high BMI on the contraceptive efficacy of
ulipristal.109 The EMA recommends that emergency contraceptives containing ulipristal continue to be
used irrespective of weight as the benefits outweigh the risks.97,98
Adverse Effects
The most common adverse reactions reported in the trials were headache, nausea, abdominal pain,
dysmenorrhea, fatigue and dizziness. While limited human data do not suggest a safety concern with
ulipristal exposure during pregnancy, it is contraindicated in women with known or suspected pregnancy.
Due to its high-affinity binding to the progesterone receptor, use of ulipristal may reduce the
contraceptive action of progestogen-containing hormonal contraceptive methods. After use of ulipristal,
a reliable barrier method of contraception should be used with subsequent acts of intercourse that occur
in that same menstrual cycle.109

Ulipristal is available as a single 30 mg tablet. The tablet should be taken as soon as possible (within 120
hours) after unprotected intercourse or known or suspected contraceptive failure. Women should be
advised of potential adverse effects. If menses does not occur within 3 weeks of the dose, assess for
possible pregnancy. Administration of ulipristal will not protect against future acts of unprotected
intercourse. Women should abstain from intercourse or use a barrier method of contraception until the
next menses occurs. If a woman wishes to start or continue hormonal contraception after taking
ulipristal, it is recommended that she wait 5 days as ulipristal may reduce the efficacy of the hormonal
contraceptive. Abstinence or backup contraception is advised for those 5 days and the first 14 days after
the hormonal contraceptive is initiated. Women may be referred as needed to an appropriate healthcare
practitioner for additional counselling regarding ongoing contraceptive methods and/or STI
services.103,109
.....
Surgical Methods of Contraception
Procedures
Surgical methods of contraception (sterilization) are one of the most effective methods of contraception. In
women, this is most commonly achieved by cutting or occluding the Fallopian tubes, thus blocking
fertilization.110 Failure rates are 0.5% when used correctly (adherence to postprocedural instructions) and
are the same with typical use.77 In men, the vas deferens is blocked or occluded (vasectomy) so that sperm
can no longer pass into the ejaculate and out of the body.110 Failure rates range from 0.1% when used
correctly (adherence to postprocedural instructions) to 0.15% with typical use.77
Selected Products for Emergency Contraception

Table 4: Selected Products for Emergency Contraception

Effects
Drug Class: Contraceptives, emergency postcoital: intrauterine device (IUD)
copper IUD Use within 7 Major: None Interferes with implantation

Flexi-T, Nova- days of Salpingitis, after fertilization. Can be
T unprotected uterine used as ongoing method of
intercourse perforation, contraception.
$70–180 as an cervical
emergency perforation,
contraceptive endometrial
embedding,
menorrhagia,
pain, infection,
ectopic
pregnancy.
Drug Class: Contraceptives, emergency postcoital: oral progestin

Effects
levonorgestrel 1.5 mg po (1 Nausea, Carbamazepine, May be taken up to 120 h

Contingency x 1.5 mg abdominal griseofulvin, modafinil, after unprotected intercourse
One, Next tablet or 2 × pain, fatigue, phenobarbital, phenytoin, but efficacy will be lower.84
Choice, 0.75 mg headache, protease inhibitors, St.
NorLevo, tablets taken dizziness, John's wort, topiramate Heath Canada advisory
Option 2, together) as breast may decrease regarding reduced
Plan B soon as tenderness levonorgestrel serum effectiveness in women
possible after (incidence is concentrations. weighing 75–80 kg and lack
$16 unprotected generally of effectiveness in women
intercourse lower than weighing ≥80 kg.85 SOGC
(most with Yuzpe recommends women who do
effective if method);82 not have access to or do not
taken within spotting, wish to use alternative
72 h) breakthrough emergency contraceptive
methods should not be
bleeding.83 discouraged from using
levonorgestrel-only
emergency contraception as
it may still provide some
benefit.86
Drug Class: Contraceptives, emergency postcoital: oral selective progesterone receptor modulator
ulipristal 30 mg po Nausea (9%), CYP3A4 inducers (e.g. Not intended for use as a
Ella within 120 h headache rifampicin, phenytoin, routine contraceptive.
of (9%), phenobarbital, Efficacy not evaluated in
$26 unprotected dysmenorrhea carbamazepine, St. John’s women with a BMI ≥35
intercourse (5%), wort, barbiturates,
or known or abdominal carbamazepine, kg/m2.
suspected pain (5%), topiramate) may decrease
contraceptive fatigue (3.5%), serum concentrations and
failure dizziness result in decreased
(3.3%). efficacy.
CYP3A4 inhibitors increase
serum concentrations.
Ulipristal binds to the
progesterone receptor with
high affinity and may
interfere with the action of
progestogen-containing
medicinal products.
Contraceptive action of
combined hormonal
contraceptives and
progestogen-only
contraception may be
reduced. Concomitant use
of ulipristal and emergency
contraception containing
levonorgestrel is not
recommended.
a Cost of 1 dose; includes drug cost only.

.....
Resource Tips
Action Canada for Sexual Health & Rights. Available from: www.sexualhealthandrights.ca.
Society of Obstetricians and Gynaecologists of Canada. SexualityandU.ca. Available from:

www.sexualityandu.ca.
Suggested Readings
Black A, Guilbert E et al. SOGC Clinical Practice Guideline. Canadian Contraception Consensus (Part 1 of 4).
J Obstet Gynaecol Can 2015;37:S1-28. Available from: sogc.org/wp-
content/uploads/2015/11/gui329Pt1CPG1510E.pdf.
Black A, Guilbert E et al. SOGC Clinical Practice Guideline. Canadian Contraception Consensus (Part 2 of 4).
J Obstet Gynaecol Can 2015;37:S1-39. Available from: sogc.org/wp-
Black A, Guilbert E et al. SOGC Clinical Practice Guideline. Canadian Contraception Consensus (Part 3 of 4):
Chapter 7–intrauterine contraception. J Obstet Gynaecol Can 2016;38:182-222. Available from:
www.jogc.com/article/S1701-2163%2815%2900024-9/pdf.
Pallone SR, Bergus GR. Fertility awareness-based methods: another option for family planning. J Am Board
Fam Med 2009;22:147-57.
References
1. Statistics Canada. Births, estimates, by province and territory. Available from:

www.statcan.gc.ca/tables-tableaux/sum-som/l01/cst01/demo04a-eng.htm. Accessed April 21,
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2. Canadian Institute for Health Information. Induced abortions reported in Canada in 2013. Available
from: www.cihi.ca/en/quick-stats. Accessed April 21, 2016.
3. Altfeld S, Handler A, Burton D et al. Wantedness of pregnancy and prenatal health behaviors. Women
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4. Wellings K, Wadsworth J, Johnson A et al. Teenage fertility and life chances. Rev Reprod 1999;4:184-
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5. Botting B, Rosato M, Wood R. Teenage mothers and the health of their children. Popul Trends 1998;
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6. Fisher W, Boroditsky R, Morris B. The 2002 Canadian Contraception Study: part 1. J Obstet Gynaecol
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7. Fisher W, Boroditsky R, Morris B. The 2002 Canadian Contraception Study: part 2. J Obstet Gynaecol
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9. Hall JE. The female reproductive system: infertility and contraception. In: Fauci AS et al., eds.
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contraception: a systematic review of 35 years of experience. Hum Reprod 2012;27:1994-2000.
93. Sivin I. IUDs are contraceptives, not abortifacients: a comment on research and belief. Stud Fam
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94. Mechanism of action, safety and efficacy of intrauterine devices. Report of a WHO Scientific Group.
World Health Organ Tech Rep Ser 1987;753:1-91.
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Bulletin 104. Washington: ACOG; 1987.
96. Glasier A, Cameron ST, Blithe D et al. Can we identify women at risk of pregnancy despite using
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97. European Medicines Agency. Assessment report. For emergency contraceptive medicinal products
containing levonorgestrel or ulipristal. 2014; EMA/464144/2014. Available from:
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_Variation/human/001027/WC500176357.pdf.
98. European Medicines Agency. Levonorgestrel and ulipristal remain suitable emergency contraceptives
for all women, regardless of bodyweight. 2014; EMA/440549/2014. Available from:
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99. Glasier A. Safety of emergency contraception. J Am Med Womens Assoc 1998;53:219-21.
100. Health Canada. Drug Product Database online query. Teva Branded Pharmaceutical Products. Plan B
[product monograph]. Available from: health-products.canada.ca/dpd-bdpp/index-eng.jsp.
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107. Trussell J, Rodriguez G, Ellertson C. New estimates of the effectiveness of the Yuzpe regimen of
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Available from: www.e-therapeutics.ca. Accessed April 21, 2016. Subscription required.
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monograph]. Available from: health-products.canada.ca/dpd-bdpp/index-eng.jsp. Accessed April 20,
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Contraceptive technology. 20th rev. ed. New York: Ardent Media; 2011. p. 435-82.

Nonhormonal Birth Control
Emergency Contraception (Birth Control)
Dysmenorrhea
Thomas E.R. Brown, BScPhm, PharmD

CPhA acknowledges the contribution of Katrina Mulherin as a previous author of this chapter.
Reproductive Physiology
Female reproductive physiology revolves around the menstrual cycle. The average length of a menstrual
cycle is 28 days, but it can range from 23–35 days. On average, a woman will menstruate 400 times from
menarche to menopause.
Female reproduction is regulated by the hypothalamic-pituitary-ovarian (HPO) axis. A normal menstrual

cycle begins with the pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus.
The release of GnRH stimulates the pituitary to release follicle-stimulating hormone (FSH) and luteinizing
hormone (LH). The rate and amplitude of GnRH pulses from the hypothalamus determine which hormone
(FSH or LH) is released by the pituitary. The first day of the menstrual cycle is identified as the first day of
menstruation, when recruitment of follicles in the ovary begins. At the start of each new menstrual cycle,
FSH stimulates a group of follicles in the ovary. These follicles produce and secrete estradiol. This is known
as the follicular phase of the menstrual cycle. By around the seventh day, one follicle becomes dominant,
continues to grow and secretes estradiol. Estradiol causes the hypothalamus to decrease GnRH release and
therefore FSH declines. This decline causes nondominant follicles to undergo atresia, i.e., they cease to
grow and eventually die. Estradiol concentrations rise throughout the follicular phase and peak just prior to
ovulation.
The follicular phase of the menstrual cycle in the ovary corresponds to the proliferative phase in the
endometrium. Estradiol released through stimulation of the follicles in the ovaries causes the endometrial
lining to proliferate.
Ovulation occurs around day 14 of the menstrual cycle. At this time the pituitary increases the secretion of
LH. A surge in LH signals the dominant follicle to rupture and release the egg into the Fallopian tube
(ovulation). The ruptured follicle undergoes luteinization and becomes the corpus luteum. Progesterone and
estradiol are produced and secreted by the corpus luteum.1 This second half of the menstrual cycle is
referred to as the luteal phase. Progesterone and estradiol concentrations rise during the luteal phase. The
corpus luteum has a 14-day lifespan; therefore, if fertilization does not occur, the corpus luteum undergoes
atresia and progesterone and estradiol concentrations fall.
The luteal phase of the menstrual cycle corresponds to the secretory phase in the endometrium.
Progesterone stimulates glandular cells in the endometrium to produce glycogen, mucus and
prostaglandins. These changes in the endometrial tissue are known as secretory changes.
If fertilization and implantation do not occur by around day 23 of the menstrual cycle, the corpus luteum
regresses, progesterone and estradiol concentrations decline, the endometrium undergoes involution and
menstruation begins.
Pathophysiology
Dysmenorrhea is defined as painful menstruation, and can be primary or secondary. Primary dysmenorrhea
is attributed to uterine contractions with no underlying pathology whereas secondary dysmenorrhea is due
to pelvic disease such as endometriosis, inflammatory disease or uterine polyps.2 The main focus of this
chapter is primary dysmenorrhea.
Prevalence
The reported prevalence of dysmenorrhea ranges from 6–80%, with the most common being 50%. The
peak incidence is in women between 20 and 24 years of age, and it decreases with age. Dysmenorrhea is
the most common cause of missed school or workdays in young women. Approximately 10% of women
will suffer from severe symptoms.2
Etiology
Dysmenorrhea occurs as prostaglandins are released from lysing endometrial cells in the luteal phase of
an ovulatory cycle. During anovulatory cycles, the endometrial tissue contains smaller amounts of
prostaglandins; therefore, these cycles are usually painless.2 Prostaglandins have a direct effect on the
endometrium and surrounding tissues, resulting in the signs and symptoms of dysmenorrhea.2
The role of prostaglandins in the pathogenesis of dysmenorrhea is well established. Women with
dysmenorrhea have higher concentrations of PGF2-alpha and PGE2 in their menstrual fluid than women
who do not complain of pain on menstruation.2 Moreover, administering these prostaglandins by
infusion induces the same discomfort and symptoms experienced by women with dysmenorrhea.
Women with dysmenorrhea have increased uterine activity, resulting in increased resting tone, increased
strength and frequency of contractions and/or dysrhythmic contractions.2
Dysmenorrhea usually begins 6–12 months after menarche and occurs only with ovulatory cycles. It
tends to decrease with age and after childbirth.3,4
Risk Factors
Onset of dysmenorrhea has been linked with age <30 years, BMI <20, early menarche (<12 years of age),
longer cycles and duration of bleeding, heavy or irregular menstrual flow, premenstrual syndrome (PMS),
pelvic inflammatory disease, sterilization, sexual assault4 and smoking.5 Protective factors may include
use of oral contraceptives, exercise, higher parity and fish intake.
The diagnosis of dysmenorrhea is based on the presence of symptoms, a normal pelvic exam and the
patient's response to therapy.3 Individuals who do not respond to a proven therapy should be
investigated for causes of secondary dysmenorrhea.2 Menstrual pain occurs a few hours before or just
after menstruation begins and usually lasts for 48–72 hours. The pain is described as cramping and is
most intense over the lower abdomen, but it may radiate to the back and inner thighs.5 Associated
symptoms include nausea and vomiting, fatigue, diarrhea and headache.2
Goals of Therapy
Relieve symptoms
Minimize time lost from work, school and other activities
Identify patients who may have secondary dysmenorrhea and require further medical assessment
Patient Assessment
Assess patients with dysmenorrhea to confirm that their complaints are consistent with the etiology, signs
and symptoms of primary dysmenorrhea (Figure 1). Cues that additional patient evaluation is required
include onset of pain more than 2 years postmenarche, symptoms that occur outside the first 3 days of
menses, changes in the severity or pattern of the pain or in the characteristics of the menstrual fluid (e.g.,
degree of flow, odour, colour, flow pattern). Response to a proven therapy for primary dysmenorrhea is
usually a confirmation of the diagnosis; therefore, if a trial fails the patient requires further assessment.
There is some evidence that exercise may reduce symptoms of dysmenorrhea;6,7 however, large, well-
designed trials are lacking. Regular aerobic exercise can also decrease stress, which may be a contributing
factor.3 A small (n=92) randomized trial suggests particular yoga poses may be beneficial in relieving
dysmenorrhea.8 The high degree of safety of these poses makes this an attractive nonpharmacologic
treatment. It is unclear whether diet is associated with dysmenorrhea; however, decreasing fat intake may be
of some benefit.9
Warm baths or applying a heating pad, heat patch or hot water bottle to the abdomen may reduce
discomfort. In a randomized controlled study, heating pads provided pain relief equivalent to the use of
ibuprofen. When both heating pads and ibuprofen were used together there was no more pain relief than
with either agent used alone; however, pain relief occurred faster when both therapies were combined.10,11
A single trial examining the use of a sericite belt (source of infrared rays) with a heat pack found a
statistically significant decrease in visual analog scale pain score for patients using the belt. The clinical
significance of this finding is doubtful and the trial design may have led to heat packs rather than the belt
causing the beneficial effect.12
Behavioral interventions such as massage with aromatic oils (lavender, clary sage, marjoram oils 2:1:1 and
rose aboolue, rose otto, clary sage, rose geranium and ginger 0.5:0.1:1:1:1),13,14 relaxation therapy,
biofeedback, pain management sessions and coping skills have been studied; however, good quality trials
are lacking.15 Surgical ablation of the pelvic nerve pathways requires further study and is not
recommended.16 Spinal manipulation has not been shown to provide benefit in dysmenorrhea.17
High-frequency transcutaneous electric nerve stimulation (TENS) may have some utility in the treatment of
dysmenorrhea.18,19 A Cochrane systematic review (10 trials in 944 subjects) examining the effectiveness of
acupressure and acupuncture found some evidence for benefit; however, due to the small number of
subjects and studies, further investigation is needed.20
For most women, drug therapy is required and nonpharmacologic measures are used adjunctively.3
For more information on pharmacologic management of dysmenorrhea, consult the Compendium of
Therapeutic Choices: Dysmenorrhea.
Pharmacologic agents that decrease the amount of prostaglandins in endometrial tissue or inhibit
prostaglandin synthesis are considered first-line therapies for the treatment of dysmenorrhea.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Ailments—Analgesic Products: Internal Analgesics and Antipyretics.
NSAIDs reduce the pain of dysmenorrhea by decreasing prostaglandin concentrations in endometrial

and menstrual fluid. NSAIDs commonly used in dysmenorrhea are included in Table 1.
Moderate or excellent pain relief is achieved more often with NSAIDs vs. placebo.21 Many NSAIDs have
been used in the management of dysmenorrhea. Some NSAIDs have theoretical advantages in terms of
site of action such as acetic acids (e.g., indomethacin), propionic acids (e.g., ibuprofen, naproxen) and
fenamates (e.g., mefenamic acid) which reduce prostaglandin concentrations in endometrial and
menstrual fluid.3 Mefenamic acid not only inhibits the formation of prostaglandins but also blocks
prostaglandins at the receptor site. The clinical significance of these pharmacologic differences is
questionable and head-to-head comparisons of NSAIDs lend little support for recommending one agent
over another in terms of efficacy.21
The NSAID should be administered with food at the onset of pain or menses and continued for 72 hours,
as the peak concentration of prostaglandins occurs in the first 48 hours.22 An initial loading dose may
help obtain faster relief of symptoms. Women who do not obtain adequate relief of symptoms may try
starting NSAIDs 1 or 2 days prior to expected menses. NSAIDs should be used for 3 cycles before being
declared a treatment failure.23 If symptoms are not relieved or if pain becomes worse, refer the patient to
an appropriate healthcare professional for further assessment.
In terms of safety, NSAIDs have higher overall rates of adverse events (combined GI disturbance, CNS
effects and hypersensitivity reactions) compared with placebo. When these events are analyzed
separately only CNS adverse effects have been shown to be statistically significant. This finding is based
predominantly on 2 trials using indomethacin and naproxen.21 Safety comparisons among NSAIDs do
not indicate the superiority of any agent in this patient population.21
NSAIDs have well-documented drug interactions and contraindications which may not be relevant with
occasional, short-term use of these agents. In dysmenorrhea, use is generally limited to 3 days; however,
the risks may outweigh the benefits and professional judgment must be used.
In several studies, neither acetaminophen nor ASA was better in providing pain relief than placebo.24,25
Two trials have shown ASA to be inferior to indomethacin and fenoprofen in terms of pain relief.21
Caution is advised regarding the use of ASA in adolescents or young adults because of the possible
association with Reye's syndrome when ASA is used for conditions such as influenza or varicella. Three
trials comparing acetaminophen with NSAIDs indicate that NSAIDs provide superior pain relief in
dysmenorrhea.21 Acetaminophen may have value as additive therapy to NSAIDs and in women with
intolerance or contraindications to NSAIDs.26
Hormonal Contraceptives
If NSAIDs are contraindicated, if they fail or if birth control is also required, a combined oral
contraceptive (COC) is often used to treat dysmenorrhea. COCs relieve dysmenorrhea symptoms by
reducing the amount of prostaglandins in menstrual fluid (because they reduce the actual amount of
fluid), and by inhibiting ovulation (dysmenorrhea occurs only in ovulatory cycles).3 COCs are up to 90%
effective in relieving dysmenorrhea symptoms.27 This evidence is garnered from older formulations of
medium- to high-dose estrogens (50–150 µg ethinyl estradiol ) plus first- and second-generation
progestogens (norgestrel, levonorgestrel or norethindrone). There are insufficient data on low-dose
estrogens (≤35 µg ethinyl estradiol) plus first-, second- or third-generation agents (desogestrel,
gestodene) or newer progestogens (drospirenone) to suggest they are as effective as the older
formulations.28 However, due to safety concerns, low-dose estrogen preparations (≤35 µg ethinyl
estradiol) are currently used. Formulations containing ≥50 µg ethinyl estradiol are no longer available in
Canada. Safety data for use of COCs in this specific population (women with dysmenorrhea) are
lacking.27
According to one randomized, double-blind, controlled trial, continuous COC regimens (3 months) do not
appear to offer any benefit beyond cyclic 28-day regimens.29 While a difference in efficacy between
continuous and cyclic regimens may exist, the evidence is weak.30
Comparative efficacy of NSAIDs vs. COCs for treating dysmenorrhea is unknown.27
The combination of a COC and an NSAID may also be beneficial. About 10% of women do not respond to
treatment with NSAIDs, COCs or both.31
Levonorgestrel-containing intrauterine systems (IUS) and oral and parenteral progestogens may have
some benefit in dysmenorrhea.32 However, larger-scale confirmatory trials are required before use can be
recommended.
For further discussion of hormonal contraceptives, consult the Compendium of Therapeutic Choices:
Contraception.
Other
Pamabrom is a mild diuretic that is marketed in combination with acetaminophen for relief of
dysmenorrhea. There are no trials to support the use of this agent in women with dysmenorrhea.
Beta 2-adrenoceptor agonists have been used to treat dysmenorrhea in the past. A 2012 Cochrane
systematic review examining these medications (isoxsuprine, terbutaline oral spray, ritodrine or
orciprenalin) in dysmenorrhea found little evidence to support their use. Given the lack of data to support
efficacy and the known side effect profile of beta 2-adrenoceptor agonists, they are not recommended
for use in dysmenorrhea.33
Ailments—Herbal and Natural Products: Single Entity; Vitamin and Mineral Products: Single Entity, Solid
Combinations.
Cholecalciferol (vitamin D3) supplementation may alleviate dysmenorrhea in women with low vitamin D
levels. In a small randomized placebo-controlled trial of menstruating women with low vitamin D levels, a
single oral dose of 1 mL cholecalciferol (300 000 IU/mL) 5 days before the anticipated commencement
of the next menstrual cycle decreased pain intensity and the requirement for NSAID use. Further
corroboration of this small trial is required.34
Alternative approaches for managing dysmenorrhea include magnesium supplements,24 omega-3 fatty
acids,35 transdermal nitroglycerin, vitamin B1,36,37 vitamin B6, vitamin E,37,38,39 shirazi thymus
vulgaris40 and valerian root.23,37,41,42 These therapies require further study to determine their role in
treating dysmenorrhea.
Chinese herbal medicine (individually-designed formulae or standard) has shown positive effects on
pain and overall symptoms, and has reduced requirement for further medication.43 However, the nature
of these individualized treatments and variations among the agents used in trials poses difficulty in
evaluating Chinese herbal medicines. While the quality of current studies precludes recommendation of
these therapies, further investigation seems warranted.
Women who do not respond to standard therapy should discuss these options with their healthcare
practitioner.
Efficacy: If a patient fails to respond to a 3-cycle trial of an NSAID and/or a combined oral contraceptive in
conjunction with nonpharmacologic measures, further assessment is required.
Safety: Inform patients taking medication for dysmenorrhea about common adverse effects and the
timeframe associated with them. Instruct patients to report any signs of serious adverse effects to their
Resource Tips
American College of Obstetricians and Gynecologists. Patient Education Pamphlet. FAQ: Frequently asked
questions. Gynecologic problems. Dysmenorrhea. Available from:
www.acog.org/~/media/For%20Patients/faq046.pdf.
Lefebvre G, Pinsonneault O, Antao V et al. Primary dysmenorrhea consensus guideline. J Obstet Gynaecol
Can 2005;27:1117-46.
Algorithms
Figure 1: Treatment of Dysmenorrhea
Abbreviations: NSAID = nonsteroidal anti-inflammatory drug; CHC = combined hormonal contraceptive
Drug Table
Table 1: NSAIDs commonly used for Dysmenorrhea
Drug/Costa Dosage Adverse Effects Drug Interactionsb Comments
Drug Class: NSAIDs

Drug/Costa Dosage Adverse Effects Drug Interactionsb Comments
ibuprofen 200–400 mg Very common Anticoagulants (increase Take with

Advil, Advil Q6–8H po; start (>10%): risk of bleeding); SSRIs food to
Liqui-Gels, with onset of dyspepsia, (may increase risk of GI minimize GI
Motrin, pain or menses nausea/vomiting. bleeding); decrease upset.
Motrin IB, and continue for Common (5– effect of Caution in
Motrin 2–3 days 10%): nonspecific antihypertensives, asthmatic
Liquid Gels, Maximum dose rash, pruritus, diuretics; may increase or ASA-
generics for self-care: dizziness, lithium levels; may sensitive
1200 mg/day po headache. increase levels of patients.
$ methotrexate (with high
Usual maximum NSAIDs may be doses methotrexate); Avoid in
dose: nephrotoxic and may inhibit phenytoin patients at
2400 mg/day po should not be metabolism. risk of
used in severe peptic ulcer
renal impairment. and in renal
impairment.
naproxen Loading dose Very common Anticoagulants (increase Take with

Naprosyn, 500 mg po; then (>10%): risk of bleeding); SSRIs food to
generics 250 mg Q6–8H dyspepsia, (may increase risk of GI minimize GI
po or 500 mg nausea/vomiting. bleeding); decrease upset.
$$ BID po effect of
Common (5– Caution in
Maximum daily 10%): nonspecific antihypertensives, asthmatic
dose: rash, pruritus, diuretics; may increase or ASA-
1250 mg/day po dizziness, lithium levels; may sensitive
headache. increase levels of patients.
methotrexate (with high
NSAIDs may be doses methotrexate); Avoid in
nephrotoxic and may inhibit phenytoin patients at
should not be metabolism. risk of
used in severe peptic ulcer
impairment.
naproxen 220–440 mg Very common Anticoagulants (increase Take with

sodium Q8–12H po; (>10%): risk of bleeding); SSRIs food to
Aleve, start with onset dyspepsia, (may increase risk of GI minimize GI
generics of pain or nausea/vomiting. bleeding); decrease upset.
menses and Common (5– effect of Caution in
$ continue for 2–3 antihypertensives,
10%): nonspecific asthmatic
days rash, pruritus, diuretics; may increase or ASA-
Maximum dose dizziness, lithium levels; may sensitive
for self-care: headache. increase levels of patients.
440 mg/day po methotrexate (with high
NSAIDs may be doses methotrexate); Avoid in
Usual maximum nephrotoxic and may inhibit phenytoin patients at
dose: should not be metabolism. risk of
1375 mg/day po used in severe peptic ulcer
impairment.

b NSAIDs have well-documented drug interactions and contraindications that may not be relevant with occasional,
short-term use of these agents. In dysmenorrhea, use is generally limited to 3 days; however, the risks may
sometimes outweigh the benefits and professional judgment must be used.
Legend: $ <$1 $$ $1–2
Suggested Readings
Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. Obstet Gynecol
2006;108:428-41.
Borgelt LM, Gunning KM. Disorders related to the menstrual cycle. In: Koda-Kimble MA, Alldredge BK, Corelli
RL et al., eds. Koda-Kimble and Young’s applied therapeutics: the clinical use of drugs. 10th ed. Philadelphia:
Wolters Kluwer; Lippincott Williams & Wilkins; 2013. p. 1149-74.
Khan KS, Champaneria R, Latthe PM. How effective are non-drug, non-surgical treatments for primary
dysmenorrhea? BMJ 2012;344:e3011.
Laufer LR, Gambone JC. Menstrual cycle-influenced disorders. In: Hacker NF, Moore JG, eds. Essentials of
obstetrics and gynecology. 5th ed. Philadelphia: WB Saunders; 2010. p. 386-9.
Lefebvre G, Pinsonneault O, Antao V et al. Primary dysmenorrhea consensus guideline. J Obstet Gynaecol
Can 2005;27:1117-46.
Osayande AS, Mehulic S. Diagnosis and initial management of dysmenorrhea. Am Fam Physician
2014;89:341-6.
References
1. Gambone JC. Female reproductive physiology. In: Hacker NF, Moore JG, eds. Essentials of obstetrics
and gynecology. 5th ed. Philadelphia: WB Saunders; 2010. p. 34-45.
2. Laufer LR, Gambone JC. Menstrual cycle-influenced disorders. In: Hacker NF, Moore JG, eds.
Essentials of obstetrics and gynecology. 5th ed. Philadelphia: WB Saunders; 2010. p. 386-9.
3. Hansen LB, Gunning K. Disorders related to the menstrual cycle. In: Koda-Kimble MA, Young LY et al.,
eds. Applied therapeutics: the clinical use of drugs. 9th ed. Philadelphia: Wolters Kluwer;Lippincott
Williams & Wilkins; 2009. p. 47-20-47-24.
4. Latthe P, Mignini L, Gray R et al. Factors predisposing women to chronic pelvic pain: systematic
review. BMJ 2006;332:749-55.
5. Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. Obstet Gynecol
2006;108:428-41.
6. Daley AJ. Exercise and primary dysmenorrhoea: a comprehensive and critical review of the literature.
Sports Med 2008;38:659-70.
7. Brown J, Brown S. Exercise for dysmenorrhoea. Cochrane Database Syst Rev 2010;2:CD004142.
8. Rakhshaee Z. Effect of three yoga poses (cobra, cat and fish poses) in women with primary
dysmenorrhea: a randomized clinical trial. J Pediatr Adolesc Gynecol 2011;24:192-6.
9. Barnard ND, Scialli AR, Hurlock D et al. Diet and sex-hormone binding globulin, dysmenorrhea, and
premenstrual symptoms. Obstet Gynecol 2000;95:245-50.
10. Akin MD, Weingand KW, Hengehold DA et al. Continuous low-level topical heat in the treatment of
dysmenorrhea. Obstet Gynecol 2001;97:343-9.
11. Potur DC and Komurcu N. The effects of local low-dose heat application on dysmenorrhea. J Pediatr
Adolesc Gynecol 2014;27:216-21.
12. Lee CH, Roh JW, Lim CY et al. A multicenter, randomized, double-blind, placebo-controlled trial
evaluating the efficacy and safety of a far infrared-emitting sericite belt in patients with primary
dysmenorrhea. Complement Ther Med 2011;19:187-93.
13. Ou MC, Hsu TF, Lai AC et al. Pain relief assessment by aromatic essential oil massage on
outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet Gynaecol
Res 2012;38:817-22.
14. Kim Y, Myenong S, Yang Y et al. Self-aromatherapy massage of the abdomen for the reduction of
menstrual pain and anxiety during menstruation in nurses: a placebo-controlled clinical trial. Eur J
Integr Med 2011;3:e165.
15. Proctor ML, Murphy PA, Pattison HM et al. Behavioural interventions for primary and secondary
dysmenorrhoea. Cochrane Database Syst Rev 2007;3:CD002248.
Male Sexual Dysfunction
Tom Smiley, BScPhm, PharmD

Introduction
Sexual dysfunction refers to difficulties engaging in sexual intercourse which may be due to physical or
psychologic factors or both. This chapter focuses on erectile dysfunction and premature ejaculation.
Erectile Dysfunction
Introduction
The Canadian Urology Association defines erectile dysfunction (ED) as the preferred clinical term to
describe persistent or recurrent inability to achieve and maintain a penile erection of sufficient rigidity to
permit satisfactory sexual activity for at least 3 months.1
It is estimated that approximately 50% of Canadian men between the ages of 40 and 88 have some degree
of ED.2 The prevalence of ED increases with age, tripling between the ages of 40 and 70 years.3 About two-
thirds of men over the age of 70 years experience ED according to the large landmark cross-sectional
Massachusetts Male Aging Study (MMAS).4
Pathophysiology
The male erection is a vascular event that is initiated by neuronal action and maintained by a complex
interplay between vascular and neurologic events.5 Parasympathetic input causes relaxation of trabecular
smooth muscle and dilation of the helicine arteries of the penis. This leads to expansion of the lacunar
spaces and entrapment of blood in the cavernous spaces. Increasing pressure within these spaces causes
the penis to become erect, resulting in compression of the venules against the tunica albuginea. The tunica
albuginea must have sufficient stiffness to compress the venules penetrating it, blocking venous outflow
and maintaining tumescence and rigidity.5 Erectile dysfunction secondary to smooth muscle
pathophysiology may be a consequence of insufficient nitric oxide for smooth muscle relaxation (e.g.,
associated with endothelial disease), an inadequate number of smooth muscle cells (e.g., cell apoptosis
from diabetes or neuropathy) and/or tunical degeneration (caused by Peyronie's disease).6
Factors that play a role in promoting ED are usually categorized as being organic, psychogenic or drug-
related.7
ED is most often associated with organic causes. Within this etiologic classification, atherosclerosis is most
prominent.8 Psychogenic causes of ED may include anxiety, depression or psychosis with a potential loss of
self-confidence. Many interrelationships between depression and ED may be possible. The occurrence of
either condition may cause, result from, or exacerbate the other.9 In the MMAS, men who scored highest on
depression scales had an almost 90% probability of moderate or complete ED compared with 25% for the
least depressed.4 Depression and ED also share a number of risk factors, including smoking, obesity,
dyslipidemia and sedentary lifestyle.9
Risk factors and potential mechanisms of ED are presented in Table 1 and drug causes of ED are presented
in Table 2.
Table 1: Risk Factors and Mechanisms of Erectile Dysfunction

Risk Factor Mechanism or Cause
Metabolic syndrome Endothelial dysfunction and down-regulation of
nitric oxide synthase
Lower urinary tract symptoms of benign Possible decrease in nitric oxide in the penis,
prostatic hyperplasia (BPH) bladder and prostate
Cardiovascular disease Possible endothelial dysfunction in penile

vasculature
Tobacco smoking Possible endothelial dysfunction, associated

atherosclerosis and sympathetic overactivity
Central neurologic conditions, e.g., Disruption of neural control or proerectile

Parkinson's disease, hemorrhagic or ischemic processes
stroke, tumors, Alzheimer's disease
Spinal cord injury Dependent on the extent and location of the

spinal lesion; nonsustained reflex erections
commonly maintained
Endocrinologic conditions such as Disruption of testosterone-mediated up-regulation

hypogonadism, hypothyroidism, of nitric oxide synthase; low testosterone levels
hyperthyroidism, hyperprolactinemia from hyperprolactinemia-influenced changes in
the hypothalamic-pituitary axis
Diabetes mellitus Vasculopathy from endothelial dysfunction and

autonomic neuropathy
Adapted with permission from McVary KT. Erectile dysfunction. N Engl J Med 2007;357:2472-81. Copyright © 2007 Massachusetts Medical
Society. All rights reserved.
Table 2: Drugs Commonly Associated with Erectile Dysfunction

Possible Alternative
Treatment or Course of
Drug Class Examplesa Action
5-alpha reductase inhibitors Dutasteride, finasteride Consult urologist
Antiandrogens Bicalutamide, flutamide, Consult oncologist

nilutamide
Antiepileptic drugs Carbamazepine, phenytoin Consult neurologist
Antidepressants Lithium, MAO inhibitors, tricyclic Bupropion, mirtazapine

antidepressants, SSRIs
Antihypertensive drugs Beta-blockers, calcium channel ACE inhibitors, angiotensin

blockers, clonidine, hydralazine, receptor blockers
methyldopa
Antipsychotic agents Butyrophenones, phenothiazines, Consult psychiatrist

risperidone
Possible Alternative
Treatment or Course of
Drug Class Examplesa Action
Cytotoxic agents Methotrexate Treatment varies according
to condition
Diuretics Spironolactone, thiazides Furosemide
H2-receptor antagonists Cimetidine, ranitidine Proton pump inhibitors
Opioids Hydromorphone, morphine, Acetaminophen, NSAIDs

oxycodone
Antiparkinsonian agents Levodopa Consult neurologist
Other Alcohol, cocaine, corticosteroids, Consult appropriate

cyclophosphamide, digoxin, specialist
luteinizing hormone-releasing
hormone agonists
a Not a comprehensive list.
Goals of Therapy
Restore erectile capacity
Patient Assessment
Refer patients with ED to an appropriate healthcare provider to evaluate the psychological and organic
factors causing ED. A thorough history including assessment of modifiable causes of ED such as blood
pressure, blood glucose, smoking, alcohol and drug use is imperative for a proper diagnosis. Men with
psychogenic erectile dysfunction (except when caused by severe depression) usually have normal nocturnal
and early morning erections. If the patient indicates the presence of rigid erections (often when awakening),
the efferent neurologic and circulatory systems that mediate erections are intact, and the dysfunction is
probably psychogenic in nature.10
An estimated 25% of ED cases may be attributable to medications prescribed for other conditions.11 It is
important to perform a detailed medication history, identify potential causative agents and recommend
alternative medications that have little or no risk of inducing erectile dysfunction (see Table 2). In some
instances, either waiting to see if tolerance to the sexual side effect develops or reducing the dose of the
offending agent is attempted before switching to another medication. If a decision is made to remove an
offending agent, advise the patient of any potential risks associated with an abrupt discontinuation, and
recommend an appropriate withdrawal schedule.
Management of erectile dysfunction consists of psychotherapy/behavioural therapy, medical treatment or

(most commonly) a combination of the two (see Figure 1).
Psychotherapy/Behavioural Therapy
Careful attention to psychological factors and attempts to alleviate sexual anxieties should be a part of
the therapeutic intervention in all patients with erectile dysfunction. Psychotherapy/behavioural therapy
alone may be beneficial for patients in whom no organic causes are detected, or in cases where patients
refuse medical/surgical interventions. Focus should be on treating coexistent problems such as issues
related to the loss of a partner, dysfunctional relationships, psychotic disorders or substance
abuse.3,12,13 This approach has been reported to relieve depression and anxiety and improve sexual
function; however, outcome data have not been quantified and success of specific techniques is poorly
documented.
Vacuum Constriction Devices

Ailments—Male Sexual Health Products: Vacuum Constrictive Devices for Erectile Dysfunction.
Vacuum constriction devices are effective in all cases of erectile dysfunction, irrespective of the
pathogenesis of ED.14 However, vacuum therapy may not be tolerated by most patients and is not usually
considered a first-line option.
Erection is induced by creating a vacuum around the penis, and it is maintained by using a constriction
band. The devices are difficult for some patients to use and may impair ejaculation, which can cause
some discomfort. Some men may experience petechiae (reddish pinpoint-sized dots) and ecchymosis
(bruising).15,16 Petechiae are caused by placing the penis under negative pressure too rapidly, and
ecchymosis is due to the penis being held under vacuum pressure too long. The major drawback of
these devices is the necessity for precoital application, making acceptance by the sexual partner of
major importance. Refer patients to their urologist for proper selection of a vacuum constriction device.
Vascular Surgery
Surgery of the penile venous system, generally involving venous ligation, has been effective in patients
with demonstrated venous leakage.3 However, evidence from longer-term follow-up studies shows
decreased effectiveness of this procedure. Arterial revascularization procedures have a limited role and
should be restricted to the clinical investigation setting in medical centres with experienced personnel.1,3
Surgery is performed in isolated cases and usually for the correction of congenital or trauma-induced
vascular abnormalities.12
Penile Prostheses
Penile prosthesis placement is indicated for a motivated patient with ED who desires reconstitution of
penile function adequate for intercourse and in whom first- and second-line treatments have failed.17
The most basic prosthesis is the semi-rigid rod prosthesis which consists of 2 rod-like cylinders that are
implanted in the corpora cavernosa. A prosthesis may have a mechanically jointed backbone or have a
malleable one that allows the phallus to be dressed upward or downward. The surgery permanently
alters the corpora, ending most hope of return to natural erections. There is also a risk of repeat surgery
with all of the devices.3
Most patients using penile prostheses have found them to be satisfactory. Those with penile fibrosis find
the device to be especially helpful.14 In a study of more than 200 men, over 88% said they would
recommend the device to a relative or a friend.18
The high initial cost of the device is a consideration.14 Perineal pain may be experienced upon insertion,
and it may last for 1–2 months.14 Sepsis may occur in 2–16% of cases. However, according to a 2-year
study the removal rate was only 4.4%.14
For further discussion of pharmacologic therapy for erectile dysfunction, consult the Compendium of
Therapeutic Choices: Male Sexual Dysfunction.
A general overview of the management of ED is presented in Figure 1.
Phosphodiesterase-5 (PDE5) is an enzyme found in trabecular smooth muscle, which catalyzes the
degradation of cGMP.8 By blocking this pathway, PDE5 inhibitors increase cellular levels of cGMP and
promote erection by up-regulation of the nitric oxide-cGMP cell-signaling system. This action enhances and
prolongs smooth muscle relaxation and vasodilation in the corpus cavernosum.19 Oral PDE5 inhibitor
therapy is considered first-line because the agents are effective, minimally invasive and associated with
minimal adverse effects. The three PDE5 inhibitors currently available on the Canadian market are sildenafil,
tadalafil and vardenafil. There is no evidence to suggest that one of these agents is more effective than
another for the treatment of ED. Tadalafil may be dosed once daily, eliminating the need for predicting when
sexual activity will take place.
PDE5 inhibitors are well tolerated, with discontinuation rates due to adverse events consistently less than
5%.8 Each PDE5 inhibitor has a specific side-effect profile that differs from the others, and that could vary
among individuals. Headaches and flushing appear to be a class effect and are usually mild and transient.
Priapism (prolonged erections over more than 4 hours) occurs infrequently with use of PDE5 inhibitors and
is considered an emergency condition. As a result of the overall effectiveness and tolerability of these drugs,
guidelines recommend PDE5 inhibitors should be offered to most patients presenting with ED and without
contraindications, e.g., concomitant nitrate use.20 Table 3 presents counselling tips for patients using PDE5
inhibitors.
Testosterone replacement therapy is indicated and effective only for ED caused by diagnosed male
hypogonadism (approximately 6% of ED sufferers).21 In men suffering from hypogonadism, testosterone
therapy has also been shown to improve libido and may positively influence bone mass.22 In a meta-analysis
of 16 studies, testosterone treatment was associated with improvement in ED in men with hypogonadism
57% of the time versus 16.7% of the time in men using placebo.23 The highest response rate was achieved
with transdermal testosterone therapy, with 80.9% of participants responding, compared with a 51.3%
response rate with intramuscular therapy and 53.2% with oral therapy.
Testosterone replacement therapy is available in oral capsule form as testosterone undecanoate, topically
as a transdermal patch or a gel, or as an injection in the form of testosterone cypionate or testosterone
enanthate. It should be discontinued in patients who do not respond to treatment within 3 months.6
Intracavernous injection is a second-line therapy to be used if PDE5 inhibitor therapy is contraindicated or

not tolerated. These injections contain alprostadil (synthetic prostaglandin E1), either alone, or in
combination with papaverine and phentolamine (“triple P” therapy). They are effective in treating erectile
dysfunction of vascular, neurogenic or psychogenic causes. Good results are attained in 70–80% of
patients.24,25,26,27 The drugs are self-injected into the corpus cavernosum through the lateral aspect of the
shaft of the penis, after cleansing the area with alcohol. Complications from intracavernosal injection may
include penile pain, priapism or fibrotic changes at the injection site.
Transurethral therapy, sometimes referred to as MUSE (medicated urethral system for erections), consists of
alprostadil pellets inserted into the urethra with a special device. This therapy is effective in approximately
43% of patients. The most common adverse effects include penile pain (32%) and urethral pain or burning
(12%).28,29,30
Table 3: Counselling Tips for Patients Using Phosphodiesterase-5 Inhibitors

Sexual stimulation is necessary for the drug to work. The drug is not an aphrodisiac.
Onset to effect is 30–60 min for sildenafil, vardenafil and tadalafil (if not using once-daily dosing)
for most men. It is advisable to take the medication at least 1 h before planned sexual activity to
increase potential for success.
High-fat meals may delay the time to onset of action with sildenafil and vardenafil.
Success increases with each use of the drug, even up to 6–8 attempts. Do not assume the drug is
not going to work if complete success is not experienced.
If the first dose of the drug is ineffective, a higher dose may be necessary.
Side effects are usually mild and temporary and may include headache, flushing or stomach upset.
Prolonged erection (lasting more than 4 h) is a medical emergency.
Scheduled patient follow up is important (see Monitoring of Therapy). Remind patients to contact
their healthcare provider should the medication lose its effectiveness or if cardiovascular status
changes. Advise patients that options exist if complete success is not achieved upon first use of
the medication.
Routinely ask patients using any type of therapy for ED about tolerability and effectiveness.
For PDE5 inhibitors, follow up with the patient 1 or 2 weeks after initial drug trial to discuss
effectiveness and any side effects. Consider timing of medication administration in evaluating whether
the medication is working. If the medication is well-tolerated but not effective, and timing is not an
issue, consider recommending an increased dose to the prescriber (if not at maximum recommended
dose). Further monitoring at the time of medication refills should assess continued effectiveness and
tolerability of the drug as well as the patient's cardiovascular status.
Monitor patients taking testosterone replacement therapy 1–3 months after initiating therapy and then
at least annually for testosterone levels, clinical response and adverse effects.16
.....
Premature Ejaculation
Pathophysiology
The International Society for Sexual Medicine defines premature ejaculation (PE) as a male sexual
dysfunction characterized by ejaculation which always or nearly always occurs prior to or within about 1
minute of vaginal penetration, or a clinically significant reduction in latency time, often to about 3 minutes or
less (acquired premature ejaculation), and the inability to delay ejaculation on all or nearly all vaginal
penetrations, with negative personal consequences, such as distress, bother, frustration and/or the
avoidance of sexual intimacy.31 There is insufficient evidence to extend this definition to situations other
than intravaginal sexual activity (e.g., men having sex with men).31
PE may be the most common male sexual dysfunction reported by patients with a prevalence of
approximately 30%.31,32 The causes of PE are largely unknown and no biological factor has been shown to
be definitively causative in the majority of men with PE.31
Organic factors are implicated in a relatively small proportion of cases of PE. These include trauma to the
sympathetic nervous system, prostatic hypertrophy, prostatitis, urethritis, alcoholism, diabetes,
arteriosclerosis, cardiovascular disease, venous leakage and polyneuritis. Premature ejaculation has been
described following withdrawal from antipsychotics and opiates.33,34,35 It is associated with the use of
desipramine and sympathomimetics (e.g., pseudoephedrine), and with alcohol-related peripheral
neuropathy.36
Goals of Therapy
Goals of Therapy
Improve sexual functioning of the patient
Improve quality of relationship between patient and sexual partner
Patient Assessment
The assessment of PE should be multidimensional to reach a sound treatment decision. This includes self-
reporting as well as behavioural, physiological and medical evaluations. Refer patients to an appropriate
healthcare provider for the proper diagnosis of PE. Medical evaluation of PE should include inquiry into
genitourinary symptoms, symptoms of generalized or localized neurological disease, previous abdominal or
pelvic trauma and use of medications.
Various nonpharmacologic treatments exist for men suffering from PE. Frequently, men will have to use a
combination of 4–5 techniques to obtain the desired results. These techniques can be taught to the
individual or to the couple.
Examples of individual procedures include:37

physiologic relaxation training (e.g., focusing on breathing, body awareness and muscle relaxation
exercises)
sensual awareness training (e.g., teaching the man to become aroused by his own sensations instead
of partner interaction)
pubococcygeal muscle control training
pelvic floor rehabilitation training
pacing techniques (e.g., stop-start technique, pause-squeeze technique)
testicular restraint technique.
Examples of techniques taught to couples include:37
sensate focus pleasuring exercises

partner genital exploration/relaxation exercises
pacing techniques
intercourse acclimatization.
The “pause-squeeze” technique by Masters and Johnson38 is considered by some specialists to offer the
best results. In this technique the partner puts one thumb on the frenulum of the penis, with the first and
second fingers of the same hand just above and before the coronal ridge. A firm grasping pressure is
applied for four seconds and then released. The pressure is applied front-to-back with the specific pressure
proportional to the degree of erection present: a firm squeeze with an erect penis; a moderate squeeze when
the penis is more flaccid. The squeeze may lead to a temporary, 10–25% decrease in the erection. This
technique is less effective when it is self-applied.38 The pause-squeeze technique is part of an elaborate
treatment regimen that the couple must follow. Initially this technique is used during mutual masturbation.
After several days of practice the couple is instructed to transfer this process to coitus. Later, a basilar
squeeze technique may be taught, where the partner applies the squeeze technique to the base of the penis,
to minimize interruptions to lovemaking.
The testicular restraint technique is a physiological aid to help delay orgasm by preventing the testicles from
ascending into the perineum. Some men can benefit from cuffing the testicles and gently pulling down.
Alternatively, Velcro-type devices and leather straps can be used to achieve the same effects. These items
are available at most stores that sell sexual aids.37
If the health professional is not comfortable discussing behavioural therapy for PE with the patient, referral
to a sex therapist, psychologist or psychiatrist is recommended.
For further discussion of pharmacologic therapy for premature ejaculation, consult the Compendium of
Therapeutic Choices: Male Sexual Dysfunction.
Ailments—Male Sexual Health Products: Premature Ejaculation.
Topical lidocaine/prilocaine cream may be used to delay ejaculation.39,40,41 The mixture available in Canada
contains 2.5% of each ingredient. If topical anesthetics are used, advise the patient to apply the cream to the
penis 20 minutes before intercourse40 and encourage application of a condom to reduce transfer of the
anesthetic to the vagina during intercourse.41
The International Society for Sexual Medicine recommends daily dosing of citalopram (20–40 mg),
clomipramine (12.5–50 mg), fluoxetine (20–40 mg), paroxetine (10–40 mg) or sertraline (50–200 mg) for
the management of PE.31 Alternatively, on-demand dosing of clomipramine, fluoxetine, paroxetine or
sertraline 3–6 hours before intercourse is also effective, albeit to a lesser extent.31 Response to treatment
usually starts within 5–10 days of regular daily dosing with antidepressants and full therapeutic benefit may
require 2–3 weeks of continuous treatment.
The International Society of Sexual Medicine guidelines do not recommend on-demand or daily dosing of
PDE5 inhibitors in the treatment of lifelong PE in men with normal erectile function, as there is conflicting
evidence regarding the safety and efficacy of this practice and more high-quality evidence is required.31
Weak evidence suggests that tramadol may be an effective option for the treatment of PE when other
therapies have failed.42 Caution must be observed due to the risk of addiction and side effects. It should not
be combined with an SSRI due to risk of serotonin syndrome. Further research is needed to assess the
efficacy and safety of tramadol in the treatment of PE.31
Inquire during regular visits about the success or failures associated with the therapy. The International
Society of Sexual Medicine guidelines recommend the question associated with the Clinical Global
Impression of Change: “Compared to before starting treatment, would you describe your premature
ejaculation problem as: much worse, worse, slightly worse, no change, slightly better, better, or much
better?”31
.....
Algorithms
Figure 1: Management of Erectile Dysfunction

Resource Tips
International Society of Men's Health (ISMH). Available from: www.ismh.org.
Remedy's Health Communities. Available from: www.healthcommunities.com/health-topics/sexual-

health.shtml.
The Sex Information and Education Council of Canada (SIECCAN). 235 Danforth Avenue, Toronto, Ontario,
M4K 1N2. (Tel.) 416-466-5304; (Fax) 416-778-0785. Available from: www.sieccan.org.
Suggested Readings
Althof SE, McMahon CG, Waldinger MD et al. An update of the International Society of Sexual Medicine's
guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014;2:60-90.
Bella AJ, Lee JC, Carrier S et al. 2015 CUA Practice guidelines for erectile dysfunction. Can Urol Assoc J
2015;9:23-9.
References
1. Bella AJ, Lee JC, Carrier S et al. 2015 CUA Practice guidelines for erectile dysfunction. Can Urol
Assoc J 2015;9:23-9.
2. Grover SA, Lowensteyn I, Kaouache M et al. The prevalence of erectile dysfunction in the primary
care setting: importance of risk factors for diabetes and vascular disease. Arch Intern Med
2006;166:213-9.
3. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA
1993;270:83-90.
4. Feldman HA, Goldstein I, Hatzichristou DG et al. Impotence and its medical and psychosocial
correlates: results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
Menopause and Perimenopause

Pathophysiology
Definition
Menopause is the cessation of menses for at least 12 consecutive months.1 This may be a naturally
occurring event or it can be related to the removal or destruction of the ovaries. On average, natural
menopause occurs at 51 years of age.1 A menopause that occurs before the age of 40 is defined as a
premature menopause, and menopause occurring after 55 years of age is considered a late
menopause.1 Perimenopause refers to the time leading up to menopause, typically characterized by
missed menstrual periods with or without symptoms of hypoestrogenism.1 Perimenopause has an
average duration of 4 years with a range of 2–8 years. The climacteric is an older term that
encompasses the perimenopause, menopause and postmenopause.
Physiology
At the time of menopause, the ovary has no follicles left that respond to the stimulation of follicle-
stimulating hormone (FSH).2 The lack of follicular stimulation and development signals the end of the
regular menstrual cycle and the monthly fluctuations of both estradiol and progesterone
concentrations.2 Without follicular development and the designation of a graafian (dominant) follicle,
estradiol concentrations remain low and ovulation does not occur; therefore, progesterone
concentrations remain low as well.2 As a result, endometrial proliferation occurs rarely and there are no
secretory changes. The pituitary gland increases the production and release of both FSH and luteinizing
hormone (LH) in an attempt to entice the ovary to initiate follicular development.2 The ovary cannot
respond; therefore, FSH and LH concentrations remain elevated while estradiol and progesterone
concentrations remain low.2
The postmenopausal female continues to produce estrogen in the adipose tissue as a result of the
conversion of androstenedione (from the adrenal gland) to estrone.2 The amount of estrone produced
depends on the amount of adipose tissue present. Estrone has a weaker effect on the endometrium than
estradiol; therefore, proliferation of endometrial tissue is rare, except in women who are obese.
During perimenopause, cessation of menses, along with the increase in FSH and LH and decrease in
estradiol and progesterone, occurs gradually over several months to years.2 The ovary becomes slow to
respond to FSH and LH. Therefore, it can take longer for follicular development and endometrial
proliferation to occur; however, unlike in menopause, the follicles in the ovary are still able to respond and
ovulation does still occur.2
Perimenopausal women may suffer from vasomotor symptoms as well as vaginal dryness. The
approach to therapy in these individuals is similar to menopausal women. However, it is important to
note that many of the therapies have been studied only in postmenopausal women. Perimenopausal
women can also suffer from premenstrual symptoms (see Premenstrual Syndrome) and must still
consider the possibility of becoming pregnant.
For the most part, menopause can be diagnosed based on the absence of menses for 12 consecutive
months and the symptoms an individual is experiencing. Blood tests are seldom of value in diagnosing
menopause.
There are several different signs and symptoms of hypoestrogenism and their onset can vary widely
among women. They can start in the perimenopausal period or present several years after menopause.1
Initially, a woman may experience changes in menstrual function such as irregular and/or heavy
periods,3 and she may also experience vasomotor symptoms. Vasomotor symptoms are often referred
to as either hot flashes or hot flushes. If they occur during sleep they are referred to as night sweats.
Approximately 85% of women experience some form of vasomotor symptom and in 25% the symptoms
can be severe. Night sweats can lead to insomnia, fatigue and irritability. Changes in menstrual function
and vasomotor symptoms may begin in the perimenopause. The menstrual irregularities end at the time
of menopause; however, the peak incidence of hot flashes occurs at the time of menopause with
maximum symptoms occurring within the first 2 years after the last period. Although most
postmenopausal women (60%) experience vasomotor symptoms for less than 7 years, symptoms may
persist for 15 years or more in up to 15% of women.1
Urogenital aging occurs after menopause and consists of vaginal dryness, pain with intercourse and
urinary incontinence.1 Other symptoms of menopause can include changes in the skin (e.g., increased
wrinkling), decreased libido, loss of memory and sleep disturbances (difficulty sleeping, fragmented
sleep). It is uncertain whether these symptoms are a result of decreased hormone concentrations or
secondary to vasomotor and urogenital symptoms. Mood disturbances (depression, anxiety) may also
accompany menopause but most appear to resolve by the age of 60.
Long-term Implications
The 3 main causes of illness and disability in developed countries for postmenopausal women are
cardiovascular disease, cancer, and osteoporosis associated fractures.1 With respect to osteoporosis,
the most rapid bone loss occurs in the first 15 years following menopause, after which bone loss
continues at a much slower rate. For more information on age-related bone health, see Osteoporosis.
Premature menopause (before the age of 40) may result from premature ovarian failure or damage to
ovarian function and is associated with osteoporosis, sexual dysfunction and premature cardiovascular
disease.1 Compared with natural menopause, induced menopause (from surgery, radiation or
chemotherapy) may also have different physiologic effects on the rate of loss of bone mass,
atherosclerosis, vulvovaginal atrophy and libido as the ovarian sources of both androgen and estrogen
are reduced prematurely and simultaneously.1
Goals of Therapy
Relieve undesirable vasomotor or urogenital symptoms of perimenopause and menopause
Prevent or minimize menopause-related bone loss
Help the woman maintain the highest possible quality of life
The healthcare practitioner can support the goals of therapy by educating women on all aspects of
menopause, including long-term health implications and options for their treatment or prevention.
Patient Assessment
It is important to determine what symptoms a woman is experiencing and the degree to which these
symptoms are bothersome (Figure 1). Women with mild symptoms may try nonpharmacologic approaches
and women experiencing only mild vaginal symptoms may try vaginal lubricants or moisturizers. Women
with more debilitating symptoms should be informed regarding the risk and benefits of hormone therapy
(HT) and nonhormonal therapies.
Exercise
A small study on the effects of exercise and vasomotor symptoms concluded that exercise decreases
hot flashes; however, HT was significantly more effective4 and a Cochrane review including this trial
concluded that the evidence is insufficient to demonstrate the benefit of exercise on vasomotor
symptoms.5 However, the benefits of regular exercise extend beyond menopausal symptom
management to positive impact on both physical and mental health, including improvements in serum
lipid levels, weight and stress levels and protection from coronary vascular disease, osteoporosis,
diabetes and breast cancer. For these reasons, women aged 18–64 are advised to accumulate at least
150 minutes of moderate to vigorous aerobic physical activity per week in bouts of 10 minutes or more
and to perform muscle- and bone-strengthening activities using major muscle groups at least 2 days per
week.1
Sexual Activity
Increasing blood flow to the pelvic region may relieve vaginal dryness and pain on intercourse. This is
usually done through sexual stimulation. Therefore, in women who are experiencing vaginal dryness,
increasing sexual activity, rather than avoiding it due to discomfort, may be beneficial.6 To increase
lubrication, sexual intercourse itself is not necessary if it is uncomfortable; any form of sexual activity
will help restore vaginal moisture.
Pelvic Floor Exercises
Kegel exercises may be of value in women who are experiencing incontinence.7 Kegel exercises involve
alternating contraction and relaxation of the pelvic muscles. The contraction is similar to trying to stop
urinating and should be held for 4–8 seconds. When done correctly, the abdominal and leg muscles are
not recruited. Kegel exercises can be done several times a day.
Lifestyle and Dietary Measures
Smoking cessation may reduce the occurrence of vasomotor symptoms.
Dietary measures such as decreasing fat intake and increasing fruit, vegetables and whole grains, along
with weight loss where appropriate, may reduce vasomotor symptoms.8
Ingestion of spicy foods, alcohol or caffeine can exacerbate vasomotor symptoms. Therefore, the
simplest strategy to reduce the number of hot flashes and night sweats is to avoid spicy foods and to
limit alcohol and caffeine intake.
There has been considerable discussion about the potential benefit of ingesting phytoestrogens to
relieve menopausal symptoms. These are plant-based substances that may have weak estrogenic
and/or antiestrogenic activity. There are 2 main types of phytoestrogens: lignans and isoflavones. They
are found in a variety of food substances; the richest dietary source of lignans is flax seed and the
richest source of isoflavones is soy products, e.g., tofu and tempeh.9 Observational studies comparing
Western and Asian women have shown that Asian women have less vasomotor menopausal
symptoms.10 This may be attributed to differences in the amounts of dietary phytoestrogens ingested by
these 2 populations.11 However, it is difficult to confirm this through prospective studies. The results of
studies looking at increasing the amount of phytoestrogens through diet have been variable and the
amount of phytoestrogens that need to be consumed remains unknown.12,13 A meta-analysis of oral
phytoestrogen intervention for postmenopausal symptoms concluded the phytoestrogens reduced the
frequency of hot flashes without serious adverse effects.14
Temperature Control
Vasomotor symptoms can be exacerbated by a warm environment. To minimize this possibility, the
indoor temperature should be kept comfortably cool, and it is recommended that a woman dress in
layers so that clothes may be removed as needed to maintain comfort.
Psychoeducational Interventions
A 2008 systematic review of 14 studies (of fair to poor quality) involving 475 women investigated
psychoeducational interventions to alleviate hot flashes.15 Five of the studies evaluated the following
strategies: education, counselling, cognitive-behavioural strategies and mindfulness-based stress
reduction and all showed improvements in vasomotor symptoms. Nine of the trials evaluated relaxation
techniques and 5 of these studies showed improvement in hot flashes, but the evidence was considered
insufficient as the results were inconsistent and the trial quality was poor. A 2014 Cochrane review
further determined the available evidence on relaxation techniques as treatment for vasomotor
symptoms in postmenopausal women was of low quality and insufficient to show effectiveness.16
Two studies examining cognitive behavioural therapy (CBT) as treatment for vasomotor symptoms in
breast cancer survivors17 and menopausal women18 showed both group and self-guided CBT were
superior to usual-care (usual-care patients received information about VMS, advice on treatment options
and symptom management, and instructions for paced breathing and relaxation). Citing this evidence,
the North American Menopause Society recommended CBT as an effective nonhormonal management
option for menopause-associated vasomotor symptoms in their 2015 position statement.19 The
manuals for both group20 and self-guided21 CBT are available to patients and healthcare practitioners.
Acupuncture
Uncontrolled trials evaluating acupuncture have shown improvement in vasomotor symptoms; however,
the results have been inconsistent. Controlled trials have shown no effect of acupuncture on reducing
hot flashes.22,23 A Cochrane review found insufficient evidence to determine whether acupuncture is
effective for controlling menopausal vasomotor symptoms but cautioned that the available evidence was
of low or very low quality.24
For further discussion of pharmacologic therapy for menopause and perimenopause, consult the
Compendium of Therapeutic Choices: Menopause.
Therapy for Urogenital Symptoms
For more information on the management of urinary incontinence, see Urinary Incontinence.
Ailments—Feminine Care Products: Vaginal Lubricants and Moisturizers.
There are nonhormonal treatment options to alleviate the dryness and discomfort of vaginal atrophy.
Vaginal lubricants (e.g., K-Y Jelly) are used prior to intercourse to provide lubrication. Bioadhesive
vaginal moisturizers, including polycarbophil gels (e.g., Replens) and hyaluronic acid gels (e.g.,
Gynatrof), are used continuously to increase vaginal moisture. A randomized, controlled trial comparing
Replens to conjugated equine estrogen vaginal cream showed that both products increased vaginal
moisture and helped restore the vaginal epithelium.25 A systematic review that compared vaginal
estrogen with nonhormonal moisturizers found patients with 2 or more symptoms of vulvovaginal
atrophy were substantially more improved using vaginal estrogens, but those with just one symptom or
only minor complaints had similar symptom resolution with either estrogen or nonhormonal
moisturizer.26
Information on nonhormonal therapy for vaginal dryness can also be found in Table 1.
Therapy for Vasomotor Symptoms
Minor Ailments—Herbal and Natural Health Products: Combinations, Single Entity.
Many of the studies evaluating the efficacy of natural health products for the treatment of
menopausal symptoms have limitations such as small size, lack of control group or other poor
design factors. Additionally, lack of standardization of natural health product composition (roots,
extracts, herb mixtures) and variability in doses used make comparisons between trials difficult.
Black cohosh is the most commonly used natural health product for the treatment of vasomotor
symptoms in Germany. One large study using black cohosh demonstrated improvements in
menopausal symptoms, however 3 small trials failed to show any improvement in vasomotor
symptoms.27,28 The Herbal Alternatives for Menopause Trial, a 1-year randomized, double-blind,
placebo-controlled trial, showed no benefit of black cohosh compared with placebo in diminishing hot
flashes and night sweats.29 A Cochrane review of trials of black cohosh concluded that there is
insufficient evidence to support its use for menopausal symptoms.30 Side effects reported with black
cohosh include GI upset and decreased blood pressure. Several cases of hepatotoxicity have been
reported but their association with black cohosh is uncertain.31 The safety of black cohosh use in
women with breast cancer is not known.
Studies evaluating phytoestrogen supplements have shown variable results. A systematic review
examined a total of 14 trials of soy- or red clover–based isoflavones for vasomotor symptoms.27 The
results for soy were mixed and the composition and dose of soy supplements varied across the
studies, making any recommendations regarding soy use difficult. No benefit was shown with the use
of red clover.27,28 A meta-analysis of oral phytoestrogen intervention for postmenopausal symptoms
concluded the phytoestrogens reduced the frequency of hot flashes without serious adverse
effects,14 while a Cochrane review of trials of phytoestrogen supplements found no evidence of
serious adverse effects but no conclusive evidence of efficacy in alleviating hot flashes or night
sweats.13 A strong placebo effect was noted in most trials.
Studies have failed to show a beneficial effect of oil of evening primrose, dong quai, ginseng or other
natural health products for reducing hot flashes.19,27,28,32
Hormone Therapy
The gold standard for treating symptoms of menopause is estrogen. Estrogen may be administered
by oral, transdermal or vaginal routes.
There are several differences between oral and transdermal estrogens. Oral estrogens cause an
increase in HDL-cholesterol, a decrease in LDL-cholesterol and an increase in triglycerides.
Transdermal estrogens primarily lower LDL-cholesterol with little change in HDL-cholesterol and no
effect on triglycerides. Transdermal estrogen also has less impact on the coagulation cascade and
gallbladder compared to oral estrogen. Therefore, transdermal therapy should be preferentially
offered to women at high risk of venous thromboembolism, women with malabsorption, women with
spontaneous or estrogen-induced hypertriglyceridemia, and obese women with metabolic
syndrome.1 Smoking induces liver enzyme activity; therefore, smokers may achieve higher
concentrations of estrogens from a transdermal system compared with oral therapy.
Progestogens are combined with estrogen to reduce the risk of endometrial cancer. Therefore, in a
woman who has had a hysterectomy, estrogens are often used alone. Progestogens can be
administered either cyclically (12–14 days each month) or continuously, whereas estrogen is usually
given continuously. Estrogens with cyclic progestogens will often produce a menstrual bleed,
whereas estrogen with continuous progestogen should induce amenorrhea after 6–8 months of
therapy.
Different types of progestogens are available.33 Oral micronized progesterone (Prometrium) does
not blunt the positive effects of estrogen on HDL-cholesterol, whereas both medroxyprogesterone
and norethindrone can blunt estrogen's positive effect. Oral micronized progesterone may also cause
sedation; therefore, it should be taken at bedtime.
Vaginal therapy (vaginal cream, vaginal tablets or vaginal ring) provides estrogen directly to vaginal
tissues and alleviates symptoms of atrophy; it may be used for the treatment of urogenital aging.
Vaginal estrogen is preferred when urogenital symptoms are the only concern and may be required if
symptoms persist while the woman is taking systemic estrogen. Specifically in the case of urinary
incontinence, there is modest evidence that vaginal estrogen lessened incontinence while systemic
estrogen worsened it.1,34
While vaginal therapy results in less systemic absorption than oral therapy, studies reported
increased serum estradiol levels with vaginal application of estrogen (especially conjugated equine
estrogen cream, compared with the tablet or ring formulations), indicating that some systemic
estrogen absorption occurs.35 However, many studies of vaginal estrogen have shown no evidence of
endometrial proliferation after 6–24 months of use; therefore, concomitant progestogen therapy or
endometrial surveillance is not generally recommended for endometrial protection in asymptomatic
(nonbleeding) women receiving an appropriate dose of vaginal estrogen therapy.1 Patients using
vaginal estrogens should be advised to adhere to the dosage and administration guidelines and to
report any bleeding or spotting to their healthcare practitioner for further evaluation.
Combined hormonal contraceptives provide effective menstrual cycle control as well as relief of
vasomotor symptoms and are an option for perimenopausal women who require supplemental
estrogen.
Alternatives to estrogen for the treatment of vasomotor symptoms include progestogen therapy
alone, clonidine, SSRIs (e.g., paroxetine, fluoxetine, sertraline, citalopram or escitalopram), SNRIs
(e.g., venlafaxine or desvenlafaxine) and gabapentin. Evidence supporting efficacy of these agents
varies from well-controlled trials to case reports and adverse effects may be significant.1,36,37
Prevention of Osteoporosis
Ailments—Vitamin and Mineral Products: Single Entity, Solid Combinations.
To prevent bone loss, intake of calcium 1200 mg daily (ideally from dietary sources) and
supplementation of vitamin D 800–2000 IU daily is recommended for women >50 years of age (see
Table 2).38,39 For more information on prevention of osteoporosis, consult Osteoporosis.
Both nonpharmacologic and pharmacologic therapies may require several weeks to months of use before
efficacy can be established. The length of therapy is variable. Vasomotor symptoms resolve within 5 years
of menopause for the majority of women; it is therefore reasonable to continue therapy for up to 5 years.
Urogenital atrophy may continue to be problematic indefinitely.
Every woman must make a subjective decision about the intrusiveness or tolerability of a given symptom
and participate fully in the decision-making process regarding therapy. Armed with accurate, current
information, she can make both short- and long-term decisions about symptom control and prevention of
heart disease, osteoporosis and other menopause or age-related health issues. Monitoring can include
asking the patient at each visit about the efficacy and side effects of her therapy, checking for interactions if
she begins (or has already started) a new therapy and answering any questions she may have.
Resource Tips
North American Menopause Society. Available from: www.menopause.org.
Society of Obstetricians and Gynaecologists of Canada. menopauseandu.ca. Available from:

www.menopauseandu.ca in English or www.mamenopause.ca in French.
Algorithms
Figure 1: Assessment of Patients with Menopausal Symptoms
Drug Tables
Table 1: Nonhormonal Topical Therapies for Vaginal Dryness

Drug Class: Lubricants, vaginal
vaginal gels Apply as Specialty None known Use prior to intercourse to

or jelly needed lubricants provide lubrication.
Astroglide, vaginally (e.g., flavoured,
Gyne- scented) may
Moistrin, K-Y contain
Jelly, others ingredients
that cause
$ local irritation.
Drug Class: Moisturizers, vaginal

hyaluronic Use None known May alter the The duration of use depends
acid vaginally absorption of on evolution of symptoms.
Gynatrof, QHS for at vaginally May be used every other day.
Zestica, least 2–3 administered Safe for use with latex,
others wk. May be hormones, polyurethane and
used for including polyisoprene condoms.
$$ longer contraceptive
periods vaginal rings.
polycarbophil Apply None known None known Use to increase vaginal

gel vaginally moisture and restore
Replens every 3 epithelium. Not to be used as
days on a occasional lubricant. Not to
$ continuous be used as a substitute for a
basis vaginal lubricant prior to
intercourse.
Legend: $ <$10 $$ $10–20

Table 2: Nutritional Requirements to Prevent Bone Loss

Interactions
Drug Class: Nutritional Supplements
calcium 1200 mg/day po When taken as a May decrease Doses

Caltrate, from all sources supplement: absorption of >500 mg/day
generics (dietary and constipation, bisphosphonates, should be
supplements) flatulence, nausea; iron, divided.
$ rarely, levothyroxine, Select product
hypercalcemia, quinolones, based on salt
hypercalciuria, tetracycline. type and
renal calcification, Separate amount of
renal stones (at administration by elemental
high doses). 2 h. calcium per
tablet.
Calcium
carbonate
requires acidic
medium for
best
absorption
(take with or
after meals).
Supplements
are available
as tablets,
chewable
forms,
effervescent
and liquid
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Interactions
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generics po from all sources intoxication (>50 calcium multivitamins
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Suggested Readings
North American Menopause Society. The 2012 hormone therapy position statement of: The North American
Menopause Society. Menopause 2012;19:257-71.
Position statement: non-hormonal management of menopause-associated vasomotor symptoms: 2015

position statement of the North American Menopause Society. Menopause 2015;22:1155-72.
Reid R, Abramson BL, Blake J et al. Managing menopause. J Obstet Gynaecol Can 2014;36:S1-80. Available
from: sogc.org/wp-content/uploads/2014/09/gui311CPG1505Erev.pdf.
Shifren JL, Grass ML; NAMS Recommendations for Clinical Care of Midlife Women Working Group. The
North American Menopause Society recommendations for clinical care of midlife women. Menopause
2014;21:1038-62.
Stuenkel CA, Davis SR, Gompel A et al. Treatment of symptoms of the menopause: an Endocrine Society
clinical practice guideline. J Clin Endocrinol Metab 2015;100:3975-4011.
References
1. Reid R, Abramson BL, Blake J et al. Managing menopause. J Obstet Gynaecol Can 2014;36:S1-80.
Available from: sogc.org/wp-content/uploads/2014/09/gui311CPG1505Erev.pdf.
2. Wren B. Menopause. In: Hacker NF, Moore JG, eds. Essentials of obstetrics and gynecology. 3rd ed.
Philadelphia: WB Saunders; 1998. p. 602-9.
3. Paramsothy P, Harlow SD, Greendale GA et al. Bleeding patterns during the menopausal transition in
the multi-ethnic Study of Women's Health Across the Nation (SWAN): a prospective cohort study.
BJOG 2014;121:1564-73.
4. Lindh-Astrand L, Nedstrand E, Wyon Y et al. Vasomotor symptoms and quality of life in previously
sedentary postmenopausal women randomised to activity or estrogen therapy. Maturitas
2004;48:97-105.
5. Daley A, Stokes-Lampard, H, Thomas A. Exercise for vasomotor menopausal symptoms. Cochrane
6. Leiblum S, Bachmann G, Kemmann E et al. Vaginal atrophy in the postmenopausal woman. The
importance of sexual activity and hormones. JAMA 1983;249:2195-8.
7. Bo K, Hagen RH, Kvarstein B et al. Pelvic floor muscle exercise for the treatment of female stress
incontinence: III. Effects of two different degrees of pelvic floor muscle exercises. Neurol Urodyn
1990:489-502.
8. Kroenke CH, Caan BJ, Stefanick ML et al. Effects of dietary intervention and weight change on
vasomotor symptoms in the Women's Health Initiative. Menopause 2012;19:980-8.
9. Murkies AL, Wilcox G, Davis SR. Clinical review 92: Phytoestrogens. J Clin Endocrinol Metab
1998;83:297-303.
10. Tham DM, Gardner CD, Haskell WL. Clinical review 97: Potential health benefits of dietary
phytoestrogens: a review of the clinical epidemiological and mechanistic evidence. J Clin Endocrinol
Metab 1998;83:2223-35.
11. Lock M. Ambiguities of aging: Japanese experience and perceptions of menopause. Cult Med
Psychiatry 1986;10:23-46.
12. Davis SR. Phytoestrogen therapy for menopausal symptoms? BMJ 2001;323:354-5.
13. Lethaby A, Marjoribanks J, Kronenberg F et al. Phytoestrogens for menopausal vasomotor
symptoms. Cochrane Database Syst Rev 2013;12:CD001395.
14. Chen MN, Lin CC, Liu CF. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and
systematic review. Climacteric 2015;18:260-9.
15. Tremblay A, Sheeran L, Aranda SK. Psychoeducational interventions to alleviate hot flashes: a
systematic review. Menopause 2008;15:193-202.
16. Saensak S, Vutyavanich T, Somboonporn W et al. Relaxation for perimenopausal and
postmenopausal symptoms. Cochrane Database Syst Rev 2014;7:CD008582.
17. Mann E, Smith MJ, Hellier J et al. Cognitive behavioural treatment for women who have menopausal
symptoms after breast cancer treatment (MENOS 1): a randomised controlled trial. Lancet Oncol
2012;133:309-18.
18. Ayers B, Smith M, Hellier J et al. Effectiveness of group and self-help cognitive behavior therapy in
reducing problematic menopausal hot flushes and night sweats (MENOS 2): a randomized
controlled trial. Menopause 2012;19:749-59.
19. Position statement: non-hormonal management of menopause-associated vasomotor symptoms:
2015 position statement of the North American Menopause Society. Menopause 2015;22:1155-72.
20. Hunter M, Smith M. Managing hot flushes and night sweats with group cognitive behaviour therapy: an
evidence-based treatment manual for health professionals. New York: Routledge; 2015.
21. Hunter M, Smith M. Managing hot flushes and night sweats: a cognitive behavioural self-help guide to
the menopause. New York: Routledge; 2014.
22. Lee MS, Shin BC, Ernst E. Acupuncture for treating menopausal hot flushes: a systematic review.
Climacteric 2009;12:16-25.
23. Carpenter JS, Neal JG. Other complementary and alternative medicine modalities: acupuncture,
magnets, reflexology, and homeopathy. Am J Med 2005;118:109-17.
24. Dodin S, Blanchet C, Marc I et al. Acupuncture for menopausal hot flushes. Cochrane Database Syst
Rev 2013;7:CD007410.
25. Nachtigall LE. Comparative study: Replens versus local estrogen therapy in menopausal women.
Fertil Steril 1994;61:178-80.
26. Rahn DD, Carberry C, Sanses TV et al. Vaginal estrogen for genitourinary syndrome of menopause: a
systematic review. Obstet Gynecol 2014;124:1147-56.
27. Nedrow A, Miller J, Walker M et al. Complementary and alternative therapies for the management of
menopause-related symptoms: a systematic evidence review. Arch Intern Med 2006;166:1453-65.
28. Low Dog T. Menopause: a review of botanical dietary supplements. Am J Med 2005;118:98-108.
29. Newton KM, Reed SD, LaCroix AZ et al. Treatment of vasomotor symptoms of menopause with black
cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med
2006;145:869-79.
30. Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms. Cochrane Database
Syst Rev 2012;9:CD007244.
31. Painter D, Perwaiz S, Murty M. Black cohosh products and liver toxicity: update. Canadian Adverse
Reaction Newsletter 2010;20:1-2. Available from: www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/carn-
bcei_v20n1-eng.php#_Black_cohosh_products.
32. Herbal medicines for menopausal symptoms. Drug Ther Bull 2009;47:2-6.
33. The Writing Group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens on heart
disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin
Interventions (PEPI) trial. JAMA 1995;273:199-208.
34. Cody JD, Jacobs ML, Richardson K et al. Oestrogen therapy for urinary incontinence in post-
menopausal women. Cochrane Database Syst Rev 2012;10:CD001405.
35. Suckling J, Lethaby A, Kennedy R. Local oestrogen for vaginal atrophy in postmenopausal women.
36. Nelson HD, Vesco KK, Haney E et al. Nonhormonal therapies for menopausal hot flashes: systematic
review and meta-analysis. JAMA 2006;295:2057-71.
37. Shams T, Firwana B, Habib F et al. SSRIs for hot flashes: a systematic review and meta-analysis of
randomized trials. J Gen Intern Med 2014;29:204-13.
38. Papaioannou A, Morin S, Cheung AM et al. 2010 clinical practice guidelines for the diagnosis and
management of osteoporosis in Canada: summary. CMAJ 2010;182:1864-73.
39. Khan A, Fortier M, Reid R et al. Osteoporosis in menopause. J Obstet Gynaecol Can 2014;36:S1-15.
Available from: sogc.org/wp-content/uploads/2014/09/JOGC-Sept2014-CPG-312_Eng_Online-
Complete.pdf.
40. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.

Menopause and Perimenopause
Pregnancy and Fertility Testing

Pregnancy Testing
Introduction
For an overview of the female reproductive cycle, see Contraception.
Once an ovum is fertilized, it may take about 9 days before it is implanted in the endometrial wall. Human
chorionic gonadotropin (HCG) is detectable in the blood and urine once the ovum is fertilized and implanted.
In healthy women, HCG is a specific marker for pregnancy, because it is produced only by the placenta.
HCG, a glycoprotein produced by the trophoblastic cells of the placenta, maintains the corpus luteum. It
replaces luteinizing hormone (LH). HCG can be detected as soon as 6–8 days after conception, and is
highest in concentration between 9 a.m. and 12 p.m. Its concentration in the blood doubles about every 2
days, reaching a peak in 60–70 days. It then decreases to a lower level for the rest of the pregnancy. The
half-life of HCG is about 5.6 hours. Following parturition it returns to baseline within 10 days. The detection
of HCG is the basis of pregnancy testing kits.1
Initial pregnancy tests can be performed on urine samples and later confirmed with a blood test. Detectable
HCG levels start at 5 mIU/mL during the first week of gestation and rise to a peak of about 100 000 mIU/mL.
Blood tests can detect levels as low as 1 mIU/mL and most urine tests are able to detect 20–100 mIU/mL.
Prior to the advent of a biological assay for HCG, pregnancy tests were performed by injecting a woman's
urine into a female rabbit. After 5 days, the rabbit was sacrificed and its uterus examined. Since HCG causes
swelling of the corpus luteum and of the uterus, a heavy/enlarged rabbit's uterus meant that the woman was
most likely pregnant.
In the 1960s, immunoassay technology allowed synthesis of an antibody that combined with HCG to
produce a precipitant or change a coloured substrate. The pregnancy testing kits in use today represent the
third generation of pregnancy testing technology.
Ailments—Home Testing Products: Pregnancy Tests.
First-generation Tests
These tests used polyclonal antibodies, which recognized multiple binding sites on HCG. Unfortunately,
these antibodies also reacted with other substances such as LH and follicle-stimulating hormone (FSH),
resulting in false-positive results. This generation of tests has been replaced by second- and third-generation
tests, which do not require sample collection and preparation, an incubation period or technical skill.
Second-generation Tests
Modern pregnancy tests employ monoclonal antibody technology and are more specific. In second-
generation testing kits, the anti-HCG antibody is bound to a solid surface such as a stick, bead or filter paper.
If HCG is present, it forms a complex with the antibody to produce a change in colour of a chromogen-
reactive enzyme. The HCG becomes sandwiched between the 2 antibodies, one attached to the test surface
and the other attached to the colour-producing enzyme.
Second-generation tests can detect HCG as early as the first day of a missed menstrual period and take a
shorter time (1–30 minutes) to perform compared with first-generation tests.
Third-generation Tests
The tests available today for home use are third-generation tests (e.g., ClearBlue, First Response) in which
the technology is even more refined. One anti-beta-subunit HCG monoclonal antibody is linked to a coloured
substrate. If present, HCG binds to this antibody and the resulting complex binds to a second monoclonal
antibody bound to a solid surface. The second monoclonal antibody is the alpha-subunit and elicits the
colour change. Ease of use and accuracy are significant advantages of third-generation tests, so much so
that one American study estimates that one third of women in the US have used third-generation pregnancy
tests.2
Pregnancy testing kits afford early detection of pregnancy in privacy, and earlier detection can permit earlier
prenatal care.3 They also enable earlier avoidance of harmful chemicals, x-rays, drugs and elective surgery,
all of which could potentially harm a developing fetus. The tests are easy to use and readily available with
numerous generic versions. They offer speed, convenience and confidentiality, along with economical cost.
Proper Use
It is important to carefully follow the manufacturers' instructions for the specific pregnancy test being used.
There may be variations among tests such as the method for collecting the urine, the length of time required
to apply urine to the test stick or the symbols used to communicate test results. It is recommended to test
at least one day after a missed period and to use the first urine sample of the morning when the HCG levels
will be most concentrated. It is advisable to collect the urine midstream to avoid contamination of the
sample. In general, urine is either collected in a small plastic cup or directly applied to a testing stick during
urination. If urine is collected in a cup, a dropper is used to place a small amount of urine on the test, or the
absorbent end of a test stick is placed into the cup for a specified amount of time. If urine is directly applied
to a test stick during urination, it is important to place the absorbent end of the stick into the urine stream
for the specified amount of time (e.g. 5 seconds). Once the urine has been applied, the test should be placed
on a clean, level surface with the result window facing up for the required amount of time indicated in the
instructions. Most third-generation tests have control windows to indicate whether the test was performed
correctly. Once the specified testing time has elapsed, the control window can confirm whether a successful
test has occurred and the test result can be read. A test is considered positive even if the indicator line or
symbol is very faint as it confirms HCG was detected in the urine.
False-positive and false-negative results are possible regardless of which generation of test is used. Human
error (e.g., holding the wrong end of the test stick in urine stream, exposing the test stick to the urine for less
than the required length of time) is usually the cause of erroneous results. The easier a test is to use, the
less likely errors will occur.
Timing of the pregnancy test is essential in that accuracy is more closely related to ovulation than to
intercourse. Sperm can remain viable in the Fallopian tubes up to 5 days after intercourse and implantation
takes an additional 6–12 days after ovulation (and subsequent fertilization). Therefore, false-negative
results are possible up to 17 days after intercourse.
Other errors leading to false results include:
Using an expired testing kit

Not following the timing recommendations (waving the stick through the urine stream too quickly)
Testing too early after conception when HCG levels are too low to be detected
Testing too late (after 60–70 days when HCG levels decline)
Soap residue, blood or protein in the urine sample
Cloudy, pink or red urine
Strong urine odour
Warm or hot water rinses of the test surface before or after sampling
Use of fertility drugs containing HCG (note: clomiphene will not affect tests), hormones, corticosteroids
Ectopic production of HCG by nontrophoblastic tumours
Conducting the test after missed or incomplete abortion.
Often pregnancy testing kits are purported to be 99% accurate and able to detect pregnancy as early as the
first day of a missed period; however, a study showed that of 7 testing kits, only 2 would have detected 95%
and 80% of pregnancies on the first day of the missed period.4 Caution is required when interpreting
pregnancy test results.
.....
Fertility Testing
Methods Used to Predict Ovulation

Table 1 compares various methods of predicting the time of ovulation, including prediction methods other
than those that are hormone-based.
Table 1: Methods Used to Predict Ovulation

Test Indicators of Ovulation
Basal body temperature Elevation of basal temperature (0.5°F or 0.28°C) over up to 3
days, lasting at least 11 days, usually continuing to day 1 of
menses5,6
Chloride ion Chloride ions levels increase about 6 days prior to ovulation
(device is a wrist band with a microcomputer chip which detects
chloride ions in perspiration on the skin).7 This test is not sold in
Canada
Cervical mucus Abundant watery discharge; clear, elastic and stretchable mucus
(tested with fingers); changes occur about 3–4 days prior to
ovulation5
Saliva Fern-like pattern on glass; changes occur about 3–4 days prior
to ovulation (saliva is licked on a slide which then is examined
under a microscope)5
Endometrial biopsy (late luteal Histology within 2 days of chronological cycle day based on LH
phase) surge1
Menstrual cycle history Most cycles are 26–30 days (range 23–35 days) with ovulation
mid-cycle, (e.g., around day 14 for a 28-day cycle). The
postovulatory phase is usually more likely to be consistently
around 14 days (e.g., in a 35-day cycle, ovulation might occur
around day 21)6
Midluteal serum progesterone Values greater than 10 ng/mL1
Urinary LH kits (ovulation Colour change 20–48 h before ovulation;8 specific time range is
prediction kits) product-dependent
Basal Thermometers
Ailments—Home Testing Products: Thermometers.
Basal body temperature is the temperature that occurs prior to rising in the morning. It can be taken orally,
rectally or vaginally but must be consistently measured the same way and at the same time each day. A
basal thermometer measures a more narrow range of temperatures than a fever thermometer (36–38°C or
96–99°F) and is able to detect small fluctuations in the basal temperature. Basal thermometers are easier to
read than fever thermometers, and digital versions measuring to 2 decimal points may be even more user
friendly.
Electronic basal thermometers combine data about menstrual cycle history with the measured temperatures
to provide information about the timing of fertility.
Progesterone is thermogenic; elevated levels cause a rise in body temperature. About 12–24 hours prior to
ovulation, a drop in temperature occurs; however, it is not always possible to detect the drop. When ovulation
occurs, the corpus luteum releases progesterone, causing a significant rise in temperature that is detectable
and lasts for several days. The temperature increase is about 0.5°F or 0.28°C and is measurable by a basal
thermometer.9 This temperature rise occurs over a period of up to 3 days and is usually maintained until the
first day of menses—day 1 of the next cycle. It is not the temperature itself that is significant, but the
maintained high temperature. A woman records her basal temperatures daily on a graph. With several cycles
of data, a pattern may emerge, i.e., the usual day of ovulation in a woman's cycle.5,6
To be relevant, the basal body temperature needs to be measured in a consistent manner. Sleep
disturbances can affect the temperature, and at least 4 hours of uninterrupted sleep is required before
taking the temperature. Air travel, especially with a change in time zones, and jet lag can adversely affect the
measurement, as can any factor that may on its own impact temperature, e.g., alcohol consumption, stress,
anxiety, or illness, including infections.
Being able to identify a rise in temperature enables a woman to determine when she is most fertile and likely
to conceive. Sexual intercourse (ideally every 2 days) during this time will increase the chance of
conception. Conversely, a woman will also know when to avoid sexual intercourse if she does not want to
conceive. For more information on contraception, see Contraception.
Some women learn to use symptothermal charting, which combines symptoms (e.g., mucus, pain, breast
tenderness, spotting) and basal body temperatures, allowing the fertile period to be more accurately
pinpointed.
Ovulation Prediction Kits

Ovulation prediction kits are not intended to be used as contraception.
Urine-based Kits
While basal thermometers identify the rise in temperature that accompanies progesterone release,
ovulation prediction tests identify the luteinizing hormone (LH) surge that precedes ovulation by
measuring its concentration in the urine. Conception is most likely to occur within 36 hours following the
LH surge; therefore, a positive ovulation prediction test identifies the most fertile phase of the menstrual
cycle.10
These tests employ polyclonal and monoclonal antibody technology. One antibody is bound to a test
surface and another to an enzyme. If LH is present, it becomes sandwiched between the two antibodies
and produces a colour change on the test surface. With no LH in the urine, the second antibody bound to
the enzyme is washed away and no colour change occurs. The colour intensity depends upon the
amount of LH present.
Most ovulation tests are mixtures of polyclonal and monoclonal antibodies. The polyclonal antibodies
may bind with either the alpha- or beta-subunit of LH or even the entire molecule. The monoclonal
antibodies are usually specific for the beta-subunit, which is a more accurate identifier of LH.11
More recently, tests are beta-subunit–specific antibodies bound to coloured latex particles. The second
monoclonal antibody is bound to the test surface. Without LH, the antibody bound to the coloured latex
is washed away.
Usually kits contain 5 daily tests that require 3–60 minutes to perform. Using the average length of her
cycle, a woman uses a chart to determine the day of her cycle on which she should begin testing. Some
test results are compared with baseline colour charts, some to the previous test and others to a control
window. These tests are up to 98.3% accurate if performed properly.12
Because of its effects on estrogen levels, women taking clomiphene should not start testing for the LH
surge until 3 days after taking their last tablet. Otherwise, the test may not accurately indicate the peak
fertility time.
Fertility Monitors
Fertility testing technology has advanced to include monitors containing software programs that more
specifically pinpoint fertility. These test kits combine the use of monitors with urine testing. The kits
contain from 5–20 urine tests and the software program tracks the cycle day, indicating when a urine
test should be performed. It usually reports the degree of fertility as low, high or peak.
These advanced tests use monoclonal technology and not only test for LH, but also for estrone-3-
glucuronide (E3G), which is a urinary metabolite of estradiol. Estradiol stimulates the secretion of
cervical mucus that is favourable for the survival and transport of sperm. The rise in estradiol levels
corresponds to the appearance of sperm-supportive cervical mucus. Estradiol levels gradually rise in the
early stage of the cycle, reaching a threshold that triggers the LH surge. With these tests, the stick is not
read visually, but is inserted into the monitor, which optically reads the test and displays the result.13
For all of these kits, urine should be collected at the same time each day, and while some tests are to be
done on the first urine in the morning, others can be performed anytime during the day as long as there is
a sufficient volume to ensure an effective concentration of LH. Human error accounts for the majority of
false readings. The inclusion of test controls and comparison of the results to the previous days' results
reduce the chance of errors.
Test results can be affected by tetracycline and other drugs that affect the menstrual cycle such as
hormonal contraceptives, fertility treatments that contain HCG or LH and hormone therapy. Pregnancy,
breastfeeding, polycystic ovary syndrome and menopause may also affect results.8 After pregnancy,
breastfeeding or discontinuation of hormonal contraceptives or other hormonal therapy, 2 consecutive
menstrual cycles are required before a woman can accurately test for LH surge.
Saliva-based Kits
Saliva-based testing detects a fern-like pattern in dried saliva seen under a microscope at a 40× to 60×
magnification. Prior to ovulation, estrogen levels rise causing an increase in the salinity of saliva, which
produces fern-like patterns when the saliva is dried. Testing is recommended to be performed first thing
in the morning before eating, drinking, smoking or brushing the teeth. The saliva sample needs to be
dried for at least 5 minutes and bubbles in the sample should be avoided. While the fern-like patterns are
usually seen 3–4 days prior to ovulation, daily testing is sometimes recommended to detect changes.
Note that not all women's saliva produces a fern-like pattern, and not all women are able to recognize this
pattern.
Proper Use
The choice of a fertility testing method or methods depends upon personal preference, motivation of the
woman or couple, physical factors (e.g., regularity of the menstrual cycle) and/or the complexity of the
testing method. While some studies of accuracy have shown urinary LH tests to be superior to other fertility
testing methods,8 factors such as human error, variability in menstrual cycles and concurrent medical
conditions can have a significant impact on the accuracy of any method.
Home diagnostic kits give an approximate time of ovulation and an indication of when a woman may be
more fertile. Each kit has a chart or graph that can be used to determine, based on the woman's cycle, when
testing should begin. These instructions should be followed for best results.
Couples using home ovulation predictor kits and/or basal body temperature charts to detect ovulation
should be instructed in the interpretation of the results. Intercourse should begin before the expected day of
ovulation and should occur at approximately 2-day intervals. This timing takes advantage of the fact that
sperm survive for up to 5 days in the female reproductive tract, especially in good cervical mucus. Because
sperm reserves of the male require at least 2 days for replenishment, more frequent intercourse may result
in small volumes and a slightly lower sperm count. The use of artificial lubricants (e.g., K-Y jelly) during
intercourse may interfere with fertility because they decrease sperm motility.
Methods Used to Detect Male Infertility

Male infertility is defined as any condition in which the male adversely affects the chances of achieving
successful pregnancy with his fertile female partner, and it is responsible for approximately 30–40% of
infertility cases. While there are many physiological causes of male infertility, it is generally related to sperm
production and quality, or ejaculation. Diagnostic evaluation begins with history, physical examination and
semen analysis.
Semen analysis examines characteristics such as sperm count, morphology and motility. Sperm count
refers to the amount of sperm in the ejaculate with the normal range defined as 20–150 million sperm/mL
of semen.14 Home sperm count tests use the bottom of this range, 20 million sperm/mL, as the threshold
for their results. A positive result indicates the sperm count is above 20 million sperm/mL, and a negative
result indicates that the count is below 20 million sperm/mL.15,16
Home sperm tests are immunodiagnostic devices, employing monoclonal antibodies that recognize the
spermatid and sperm-specific acrosomal protein SP-10. SP-10 is readily released from the sperm’s
acrosomal compartment with mild detergents and remains soluble in aqueous solutions, making it available
for detection by monoclonal antibodies.15
To perform the test, men are advised to wait at least 48 hours, but not more than 7 days, after their last
ejaculation to collect their semen sample. For testing, semen is ejaculated directly into a collection cup and
allowed to stand for 20–60 minutes to allow it to liquefy (it is too thick to be tested immediately after
ejaculation). A pipette is then used to stir the semen and draw a sample which is added to a detergent-
containing buffer solution. The mixture is gently agitated and allowed to stand for 2 minutes before being
applied directly to the sperm test assay device. Test results are read 7 minutes after the semen mixture is
applied to the assay. The test contains a control line and a test line. A test is positive if any line at all appears
at the test position, regardless of how dark or faint it may be. If no line appears in the control position, the
test did not run correctly and the results are not valid.16
Human error at any stage in the testing process can impact the validity of the results. Some common
causes of error include testing a sample collected less than 48 hours after previous ejaculation; not
collecting the entire ejaculate, especially the initial drops; not waiting for the sample to liquefy (minimum 20
minutes, up to 3 hours); not adding the correct amount of semen to the buffer solution; adding solid material
from the sample to the buffer solution; not adding the correct number of drops of the sperm mixture to the
test device; applying the sperm mixture to the incorrect area on the test device; or reading the test
incorrectly due to poor lighting or vision.16
As male infertility cannot be diagnosed on the basis of sperm count alone, the role of the home sperm count
test is limited to that of a front-line self-diagnostic tool to direct men to a fertility specialist. The test may
assist couples concerned about their fertility in deciding whether to seek comprehensive clinical evaluation
of the fertility status of the male partner. While a negative result may indicate infertility, it is important to
appreciate that a positive result cannot be interpreted as confirmation of fertility.
.....
References
1. Stanford JB, White GL, Hatasaka H. Timing intercourse to achieve pregnancy: current evidence.
Obstet Gynecol 2002;100:1333-41.
2. Pray WS, Pray GE. Detecting pregnancy and ovulation with home test kits. US Pharm 2012;37:12-5.
3. Gannon K. Who is most apt to turn to a home pregnancy test? Drug Topics 1992;136:46.
4. Cole LA, Sutton-Riley JM, Khanlian SA et al. Sensitivity of over-the-counter pregnancy tests:
comparison of utility and marketing messages. J Am Pharm Assoc (2003) 2005;45:608-15.
5. Pyper CM. Fertility awareness and natural family planning. Eur J Contracept Reprod Health Care
1997;2:131-46.
6. Moghissi KS. Accuracy of basal body temperature for ovulation detection. Fertil Steril 1976;27:1415-
21.
7. Lennard J. Advanced technology for fertility prediction. US Pharm 2006;12:49-54.
8. Eichner SF, Timpe EM. Urinary-based ovulation and pregnancy: point-of-care testing. Ann
9. Downs KA, Gibson M. Basal body temperature graph and the luteal phase defect. Fertil Steril
1983;40:466-8.
10. Corsan GH, Ghazi D, Kemmann E. Home urinary luteinizing hormone immunoassays: clinical
applications. Fertil Steril 1990;53:591-601.
11. Engle JP. Ovulation predictors. Am Drug 1993;207:55.
12. When the test really counts: part two: the fertility window. Consum Rep 2003;68:48-50.
13. Miller PB, Soules MR. The usefulness of a urinary LH kit for ovulation prediction during menstrual
cycles of normal women. Obstet Gynecol 1996;87:13-7.
14. Essential Evidence Plus. John Wiley & Sons, Inc. Infertility (male). Available from:
www.essentialevidenceplus.com. Accessed September 17, 2015. Subscription required.
15. Coppola MA, Klotz KL, Kim KA et al. SpermCheck Fertility, an immunodiagnostic home test that
detects mormozoospermia and severe oligozoospermia. Hum Reprod 2010;25:853-61.
16. SpermCheck Fertility. Instructions for use. Home sperm test for male fertility. Available from:
www.spermcheck.com/wp-content/uploads/2012/05/SCF_US-FNL-INSERT.pdf. Accessed
September 17, 2015.
Premenstrual Syndrome

CPhA acknowledges the contribution of Katrina Mulherin as a previous author of this chapter.
Pathophysiology
Definition
The term premenstrual syndrome (PMS) refers to the cyclic recurrence of physical and/or cognitive (behavioural) symptoms during the luteal phase of the menstrual
cycle (after ovulation), that ameliorate upon onset of menses.1 Premenstrual dysphoric disorder (PMDD) is a severe subtype of PMS that includes significant mood
changes and impairment of functioning.1 For a more complete discussion of the menstrual cycle see Contraception or Dysmenorrhea.
PMS symptoms occur in 90% of women of reproductive age at some point in life,1 whereas PMDD affects 3–8% of women.1 The main focus of this chapter is PMS.
Etiology
The etiology of PMS has not been fully elucidated.2,3 Several theories have been proposed involving fluctuations in hormonal levels during the menstrual cycle,
dysregulation of neurotransmitter systems and nutritional deficiencies.
Increased sensitivity to normal fluctuations in sex steroid hormones (estradiol and progesterone) during the menstrual cycle has been proposed as a possible etiologic
factor in PMS.2,4 A study of premenstrual women demonstrated that the occurrence of symptoms was due to an abnormal response to normal hormonal fluctuations.5
Because ovarian sex hormones can affect the synthesis, release, reuptake and inactivation of neurotransmitters,6 fluctuations in these hormones may lead to PMS or
PMDD in susceptible women.4
Serotonin is a neurotransmitter that plays a role in modulating mood and behaviour.7 Studies have shown that women with PMS have lower whole blood serotonin
concentrations and decreased platelet uptake of serotonin during the late luteal phase of the menstrual cycle, compared with control subjects.7 Decreased serotonergic
neurotransmission may be associated with depressed mood, irritability, anger, aggression, poor impulse control and appetite disturbances.7
Although evidence for serotonin abnormalities in PMS is the most convincing, abnormalities in the catecholaminergic, gamma-aminobutyric acid (GABA) and opioid
neurotransmitter systems have been observed in women with PMS.2,4,8 Additionally, the association between negative mood and the luteal phase of the menstrual cycle
has been questioned in a systematic review of 47 studies collecting prospective data on mood and menstrual cycles.9
Risk Factors
A case-control study of over 3000 American women aged 27–44 found higher doses of vitamin D lowered the risk of developing PMS. Specifically, women with median
daily vitamin D intake of 706 IU had a relative risk of experiencing PMS of 0.59 compared with women with median daily intake of 112 IU.10 A subsequent case-control
study of 186 women aged 18–30 found no relationship between low plasma levels of late luteal phase 25-hydroxyvitamin D3 and PMS, but similar to the first study, found
a lower risk of PMS in women who consumed ≥100 IU/day of vitamin D.11 Research to date does not address whether vitamin D monotherapy is effective in treating
PMS. Deficiencies in certain nutrients such as calcium, magnesium, manganese, vitamin B6, vitamin E and linoleic acid have been reported in PMS.4 However, consistent
excess or deficiency in these dietary factors has not been clearly documented in women with PMS as compared with control subjects.12
PMS is twice as prevalent in identical twins compared with fraternal twins, suggesting a genetic predisposition to PMS.2,4
Evidence suggests that high body mass index,13 stress14 and traumatic life events15 may be risk factors for experiencing PMS. Low parity, oral contraceptive use,
menstrual cycle characteristics and socioeconomic or lifestyle variables are not consistently associated with the development of PMS.4
PMS is frequently a diagnosis of exclusion, as there is no currently accepted diagnostic test for this condition.4,16,17 Indeed, some clinicians challenge the very existence
of PMS.16 The differential diagnosis may include anemia, diabetes, thyroid disorders, chronic fatigue syndrome, endometriosis, polycystic ovaries, adverse effects from
oral contraceptives, perimenopause, fibrocystic breast changes and various psychiatric disorders.4,16 These conditions should be considered before a firm diagnosis of
PMS is made.
A diagnosis of PMS is generally agreed upon if symptoms:16
are present during the luteal phase of the menstrual cycle

reach their peak shortly before the beginning of menstruation and remit at the onset of menses or shortly thereafter
are severe enough to interfere with daily functioning and interpersonal relationships
are absent during the follicular phase of the menstrual cycle.
The diagnosis of PMS is confirmed through prospective monitoring of a woman's symptoms during at least 2 menstrual cycles.4,16,18 A daily symptom calendar can be
used to determine whether the woman's symptoms are cyclical and are confined to the luteal phase.
Over the last several decades, research into PMS has identified over 100 premenstrual symptoms.19 Symptoms of PMS can be divided into 2 broad categories: cognitive
(or behavioural) and physical (Table 1).3 The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) includes PMDD as a formal diagnosis.20,21
However, debate continues surrounding the potential for pathologizing normal female physiology in establishing diagnoses for PMS and PMDD.22
Table 1: Symptoms of Premenstrual Syndrome

Cognitive/Behavioural Physical
Aggression Acne
Anger Appetite change

Cognitive/Behavioural Physical
Anxiety Bloating, fluid retention, oliguria
Depression Breast pain or swelling
Fatigue Constipation
Forgetfulness Dizziness or vertigo
Hostility Fatigue
Irritability Headache
Lethargy Hot flashes
Mood lability Muscle aches
Panic attacks Nausea and vomiting
Poor concentration Pelvic heaviness or pressure
Reduced coping skills Weight gain
The onset of PMS and related symptoms can occur at any time after puberty23 with typical onset in the mid-twenties.1 Women usually seek treatment in their thirties.4,23
Perimenopausal women can suffer from PMS, but it subsides after menopause.
The number of symptoms required for a diagnosis of PMS is not consistent among different authorities.16,23 The criteria developed by the American College of
Obstetricians and Gynecologists require the presence of at least 1 symptom from a list of specific cognitive and physical symptoms during the 5 days prior to menses
and occurring over several cycles. Symptoms must cause social or economic decline in function.24,25 To prevent overdiagnosis of this condition, it is suggested that the
presence of 5 or more symptoms that change in severity throughout the menstrual cycle is appropriate for a diagnosis of PMS.23
Goals of Therapy
Relieve symptoms
Minimize functional impairment
Healthcare practitioners can support these goals by providing patient education about the pathophysiology of PMS, the proper use of symptom diaries to evaluate
symptoms and available treatment options.
Patient Assessment
For a diagnosis of PMS, patients should prospectively report, for at least 2 menstrual cycles, symptoms in the latter half of their cycle. Table 2 presents a sample chart that
patients may use to record their symptoms. These complaints should be cyclic in nature, i.e., they should resolve at the start of menses and not be present during the entire
menstrual cycle (see Pathophysiology, Clinical Presentation). Refer patients who have severe, debilitating symptoms with a strong affective or psychological component for
assessment of possible PMDD (see Table 3). Women with mild to moderate symptoms of PMS often do not seek or require pharmacologic treatment.1
a
Table 2: Sample Monitoring Chart for Premenstrual Symptoms
Day of
Menstrual 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Cycle
Affective or Cognitive Symptoms
Aggression
Anger
Anxiety
Depression
Fatigue
Forgetfulness
Hostility
Irritability
Lack of
energy
Mood swings
Day of
Menstrual 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Cycle
Panic attacks
Poor
concentration
Reduced
coping skills
Physical Symptoms
Acne
Appetite
change
Bloating, fluid
retention,
less urine
than usual
Breast pain
or swelling
Constipation
Dizziness or
vertigo
Fatigue
Headaches
Hot flashes
Muscle aches
Nausea and
vomiting
Pelvic
heaviness or
pressure
Weight gain
a Rate symptoms according to severity (e.g., 3 = severe, 2 = moderate, 1 = mild, 0 = absent).
Table 3: DSM-5 Diagnostic Criteria for Premenstrual Dysphoric Disorder (PMDD)

A. In the majority of menstrual cycles, at least five symptoms must be present in the final week before onset of menses, start to improve within a
few days after the onset of menses and become minimal or absent in the week post menses.
B. One (or more) of the following symptoms must be present:

1. Marked affective lability (e.g., mood swings, feeling suddenly sad or tearful, or increased sensitivity to rejection).
2. Marked irritability or anger or increased interpersonal conflicts.
3. Marked depressed mood, feelings of hopelessness or self-deprecating thoughts.
4. Marked anxiety, tension and/or feelings of being keyed up or on edge.
C. One (or more) of the following symptoms must additionally be present, to reach a total of five symptoms when combined with symptoms from
Criterion B above.
1. Decreased interest in usual activities (e.g., work, school, friends, hobbies).
2. Subjective difficulty in concentration.
3. Lethargy, easy fatigability or marked lack of energy.
4. Marked change in appetite, overeating or specific food cravings.
5. Hypersomnia or insomnia.
6. A sense of being overwhelmed or out of control.
7. Physical symptoms such as breast tenderness or swelling, joint or muscle pain, a sensation of “bloating,” or weight gain.
Note: The symptoms in Criteria A–C must have been met for most menstrual cycles that occurred in the preceding year.
D. The symptoms are associated with clinically significant distress or interference with work, school, usual social activities or relationships with
others (e.g., avoidance of social activities; decreased productivity and efficiency at work, school or home.)
E. The disturbance is not merely an exacerbation of the symptoms of another disorder, such as major depressive disorder, panic disorder,
persistent depressive disorder (dysthymia) or a personality disorder (although it may co-occur with any of these disorders.).
F. Criterion A should be confirmed by prospective daily ratings during at least two symptomatic cycles. (Note: The diagnosis may be made
provisionally prior to this confirmation.)
G. The symptoms are not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication, other treatment) or another
medical condition (e.g., hyperthyroidism).
Reprinted with permission from the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, (Copyright ©2013). American Psychiatric Association. All Rights Reserved.
Figure 1 presents the suggested management of patients with PMS.
Lifestyle Modifications
Relaxation and stress reduction techniques (reflexology, massage, biofeedback) and treatments such as acupuncture and light therapy, although not rigorously studied,
can be recommended to women suffering from PMS as a means of promoting a healthy lifestyle and symptom control.1,26,27 Because symptoms of PMS can include
both insomnia and hypersomnia, encourage appropriate sleep hygiene techniques (see Insomnia).1,4 Symptom diaries (Table 2) confer a sense of understanding and
control of PMS and are recommended for monitoring and improvement in the symptoms themselves.23
Data suggest regular moderate exercise has a beneficial effect on the symptoms of PMS4,23,28 including breast tenderness, fluid retention, stress and depression.4,28
Encourage women to engage in moderate aerobic activity 3–4 times weekly as a method of alleviating their symptoms.4
Dietary Modifications
In a study on the effects of caffeine restriction, a large proportion of women who refrained from consuming methylxanthine-containing foods and beverages noted
improvement in breast symptoms.12 Although data are limited, it is reasonable to recommend that women who suffer from PMS limit their intake of caffeine from coffee,
tea, chocolate and caffeine-containing soft drinks.12,29
Carbohydrate intake may lessen appetite changes and cognitive symptoms.30 Recommend small, frequent carbohydrate servings to women experiencing these
symptoms.
Restricting salt intake in the luteal phase has been suggested as a method of alleviating PMS symptoms of fluid retention, weight gain, bloating and breast swelling and
tenderness.23,25 Although not studied, it is a reasonable recommendation for reducing PMS symptoms.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Analgesic Products: Internal Analgesics and Antipyretics;
Feminine Care Products: Dysmenorrhea and Premenstrual Syndrome Symptom Relief; Vitamin and Mineral Products: Single Entity, Solid Combinations.
The use of prostaglandin inhibitors is based on a theory that PMS results from an excess of prostaglandins.23 NSAID choices include ibuprofen and naproxen. Ibuprofen and
naproxen are expected to provide symptomatic relief of headache, breast pain and muscle aches experienced during PMS.4,23 Ibuprofen or naproxen should be started at the
onset of pain and used short-term in the lowest effective dose. For more information see Headache.
A randomized, controlled trial showed that calcium 1200 mg daily (in the form of calcium carbonate) was more effective than placebo for reducing symptoms of negative
affect, water retention, food cravings and pain in women with PMS. The authors speculated that calcium supplementation might act to replace a calcium deficit, leading to
decreased parathyroid hormone secretion and reduced neuromuscular irritability and vascular reactivity.31 Calcium has the strongest evidence among herbs, vitamins and
minerals for its use in PMS (see Table 4).32,33
Several small, randomized, placebo-controlled trials have shown magnesium to be a promising treatment alternative for premenstrual symptoms such as fluid retention.4,23
Although the evidence is not definitive for magnesium,24 if a woman chooses to try this supplement, a dose of 200–400 mg daily throughout the cycle could be
recommended.4 A mild laxative effect has been observed with higher doses of magnesium (see Table 4).4
The rationale for using pyridoxine (vitamin B6) in the treatment of PMS stems from the fact that it is a cofactor in the synthesis of dopamine and the metabolism of
tryptophan (a serotonin precursor).12 Vitamin B6 increases the inhibitory to excitatory amine ratio, which could theoretically alleviate PMS, as several symptoms are thought
to represent an excitatory state of the CNS.12 Some evidence supports the use of vitamin B6 in the treatment of premenstrual symptoms.32,34,35,36 A meta-analysis of 9
trials36 and a systematic review34 studying the use of vitamin B6 in PMS concluded that it is likely beneficial in treating premenstrual symptoms and premenstrual
depression. Vitamin B6 can be recommended in doses of 50–100 mg daily.34,35,36 Doses exceeding 200 mg daily have been associated with peripheral neuropathy (see
Table 4).36
Although vitamin E has been proposed as a potential treatment of PMS, there is no definitive evidence to support its efficacy.23
Several combination products include an analgesic as well as pamabrom (a diuretic) and/or pyrilamine (an antihistamine). Evidence that the addition of these 2 agents
offers superior efficacy over an analgesic alone is not available. Most experts believe that if these 2 agents have added benefit, their effects are mild at best.
Oral contraceptives (OCs) containing ethinyl estradiol and various first-, second- and third-generation progestogens have been used to treat PMS but there are few data to
support use.1,25 Psychological response to hormonal fluctuations is thought to be responsible for PMS. OCs halt ovulation but also cause hormonal fluctuations which may
explain lack of efficacy for cognitive symptoms.25 Physical symptoms may improve but adverse effects from OCs are similar to PMS symptoms and patients may find OCs
cause more problems.1 If an OC is used, theoretically, a monophasic preparation might be preferred.1,25 Initial studies of 4 months of continuous daily ethinyl estradiol 20 µg
and levonorgestrel 90 µg for treatment of PMS and PMDD indicates questionable efficacy in short-term trials. The high placebo response suggests little clinical benefit for
this treatment.37
OCs containing ethinyl estradiol 20 or 30 µg plus drospirenone 3 mg have been studied in PMS and PMDD. Drospirenone is an antimineralocorticoid progestogen with a
similar diuretic effect to spironolactone 25 mg. This diuretic effect, coupled with the reduced hormonal fluctuations seen with monophasic OCs, provides a theoretical basis
for its efficacy in PMS. The 20 µg strength of ethinyl estradiol plus drospirenone 3 mg (24/4 preparation where 24 days of active tablets are followed by 4 days of inert
tablets) has been approved in the United States for use in women with PMDD who wish to use OCs for contraception. A Cochrane review of drospirenone-containing OCs
concluded that drospirenone 3 mg/ethinyl estradiol 20 µg combinations may be effective for endpoints of symptom severity and functional improvement in women with
PMDD, but efficacy was not shown beyond 3 months of treatment.38 Placebo response was high, suggesting little clinically significant effect. No benefit was seen in patients
experiencing less severe PMS symptoms.38 In Canada OCs containing drospirenone (21/7 and 24/4 preparations) are indicated for contraception but not for PMS or PMDD.
Observational studies and systematic reviews have found an increased relative risk of venous thromboembolism (VTE) in women using drospirenone-containing products
compared with combination OCs containing levonorgestrel or norgestimate.39,40,41,42,43,44,45 These findings were supported by population-based, case-control studies in 2
large primary care databases in the United Kingdom.46 Women who have a family history of VTE or cancer, are on bed rest, or who have other risk factors predisposing to
VTE may not be candidates for a drospirenone-containing OC. Given the lack of evidence for sustained clinical benefit for PMDD, consider the risk-benefit ratio of using
drospirenone-containing OCs.
Progestogens other than drospirenone require further high-quality trials to determine whether they ameliorate symptoms of PMS.47
The SSRIs citalopram, escitalopram, fluoxetine, paroxetine and sertraline may be effective in treating symptoms of PMS/PMDD.48 A 2013 Cochrane review examined 31
trials comparing various SSRIs with placebo for effectiveness in PMS and PMDD. SSRIs appeared to have a more defined benefit in women experiencing PMDD than PMS as
most of the trials enrolled predominantly women experiencing PMDD. Benefit was seen at low, moderate or high doses whether they were taken continuously or only in the
luteal phase of the menstrual cycle. Statistically significant differences in efficacy were apparent, however the degree of clinical significance is questionable. The trials were
conducted over a limited 2- to 6-month period and therefore effectiveness beyond 6 months has not been established. Risk of experiencing an adverse effect at a moderate
and high SSRI dose was considerable, particularly asthenia and nausea. Notably, the review included predominantly industry-funded trials of low to moderate quality.
The Cochrane review suggested physical symptoms may also be ameliorated by SSRIs; however, it may be that these patients had a mixture of psychological and physical
manifestations. An earlier secondary analysis of SSRI effectiveness in PMS and PMDD indicated psychological benefits in PMS and PMDD but not physical relief.49 Patients
with physical symptoms only may not find SSRIs effective.
Other antidepressants such as clomipramine, duloxetine and venlafaxine have also been used in PMS but have comparatively less support than SSRIs for use in this
population.1
Other therapies include spironolactone for breast tenderness and fluid retention, as well as bromocriptine for breast tenderness.1 The dopamine agonist cabergoline (0.5
mg daily on day 14 and day 21 of the menstrual cycle) showed similar efficacy to bromocriptine for breast tenderness associated with PMS in a preliminary trial.50 GnRH
analogues (e.g., goserelin, leuprolide, nafarelin) and danazol (used during luteal phase) are reserved for severe or unresponsive cases of PMS due to their extensive and
serious adverse effect profiles.1
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Herbal and Natural Health Products: Single Entity.
Oil of evening primrose has been shown to be no better than placebo in relief of PMS-related symptoms.29,51,52 St. John's wort has a lack of well-designed trials to
support use.1,53 A Cochrane review found one well-designed trial that supported the use of jingqianping granule, a traditional Chinese medicine for increasing the rate of
recovery from PMS. However, further study is needed before this remedy can be recommended.54 Ginkgo biloba has been shown to decrease the severity of both
physical and psychological symptoms of PMS in a preliminary trial.55 At this time, there is insufficient evidence to recommend these strategies as appropriate methods
of treating PMS.
Chasteberry has been found to have benefit in reducing cyclical breast discomfort and for improving symptoms of PMS overall.1,32,56,57 However, variances in dosing
and study design complicate recommendations. Doses used in trials include 4 mg daily of an extract standardized to 6% of agnuside, 20–40 mg daily of the fruit extract,
40 drops daily of a fluid extract or 35–45 drops 3 times daily of a tincture.57 Side effects of chasteberry include dizziness, headache, fatigue, dry mouth and mild GI
discomfort. A trial comparing chasteberry with fluoxetine found similar efficacy between the 2 treatments.58
Encourage women to self-monitor their response to various treatment measures by charting their symptoms regularly (Table 2).
Efficacy: Women with unrelenting or progressive symptoms despite drug therapy for 1–3 months (depending on drug and degree of response) should have treatment
reassessed.
Safety: Adverse effects of drugs should be screened at appropriate intervals depending on therapy chosen.
Resource Tips
Massachusetts General Hospital. MGH Center for Women's Mental Health. PMS & PMDD. Available from: www.womensmentalhealth.org/specialty-clinics/pms-and-pmdd/.
U.K. National Health Service. Choices: your health, your choices. Premenstrual syndrome (PMS). Available from: www.nhs.uk/Conditions/Premenstrual-
syndrome/Pages/Introduction.aspx.
Algorithms
Figure 1: Treatment of Patients with Premenstrual Syndrome (PMS)

Drug Table
Table 4: Selected Therapies for Premenstrual Syndrome
Drug/Costa Dosage Adverse Effects Drug Interactions Comments
Drug Class: Minerals
calcium 1200 mg Constipation. Caution in severe renal Decreases absorption of Improvement in mood, water retention,
Caltrate, (elemental impairment. bisphosphonates, iron, cravings, pain; corroborating trials are
generics calcium) daily in levothyroxine, phenytoin, required to confirm efficacy.
divided doses po phosphate, quinolones,
$$ tetracyclines.
Antacid effect may alter absorption
of other medications; calcium
dosing should be separated from
other medications by 2 h.
May decrease therapeutic effect of
calcium channel blockers.
May enhance inotropic effects of
digoxin and lead to arrhythmias.
Thiazide diuretics decrease
excretion of calcium and may
increase risk of hypercalcemia.
magnesium 200–400 mg daily Diarrhea, asthenia, dizziness. Magnesium salts decrease GI Good quality evidence is lacking to
generics po absorption of drugs dosed support use, but may be helpful for fluid
concomitantly; dosing should be retention. Contraindicated in severe renal
$ separated by 2 h. impairment and heart block.
Drug Class: Vitamins
pyridoxine 50–100 mg daily Nausea, headache, paresthesia. Metabolism of levodopa increased; Do not exceed recommended dose.
generics po Sensory neuropathy (ataxia, numbness effect prevented when levodopa
Do not exceed of hands and feet) has occurred with combined with carbidopa.
$ 200 mg/day chronic use of large doses. High doses (80–200 mg/day) may
increase metabolism of phenytoin
and barbituates.
Estrogen therapy increases
pyridoxine requirements.

Legend: $ < $3 $$ $3–6
Suggested Readings
Douglas S. Premenstrual syndrome. Evidence-based treatment in family practice. Can Fam Physician 2002;48:1789-97.
Borgelt LM, Gunning K. Disorders related to the menstrual cycle. In: Koda-Kimble MA, Alldredge BK, Corelli RL et al., eds. Koda-Kimble and Young’s applied therapeutics: the
clinical use of drugs. 10th ed. Philadelphia: Wolters Kluwer; Lippincott Williams & Wilkins; 2013. p. 1149-74.
Jarvis CI, Lynch AM, Morin AK. Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. Ann Pharmacother 2008;42:967-78.
Jurgens T, Whelan AM. Advising patients on the use of natural health products to treat premenstrual syndrome. Can Pharm J 2009;142:228-33.
Laufer LR, Gambone JC. Menstrual cycle-influenced disorders. In: Hacker NF, Gambone JC, Hobel CJ, eds. Hacker and Moore's essentials of obstetrics and gynecology. 5th ed.
Philadelphia: Saunders;Elsevier; 2010. p. 386-9.
Yonkers KA, O'Brien PM, Eriksson E. Premenstrual syndrome. Lancet 2008;371:1200-10.
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41. Parkin L, Sharples K, Hernandez RK et al. Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: nested case-
control study based on UK General Practice Research Database. BMJ 2011;342:d2139.
42. Jick SS, Hernandez RK. Risk of non-fatal venous thromboembolism in women using oral contraceptives containing drospirenone compared with women using oral
contraceptives containing levonorgestrel: case-control study using United States claims data. BMJ 2011;342:d2151.
43. Gronich N, Lavi I, Rennert G. Higher risk of venous thromboembolism associated with drosperenone-containing oral contraceptives: a population-based cohort study.
CMAJ 2011;183:E1319-25.
44. Wu CQ, Grandi SM, Filion KB et al. Drospirenone-containing oral contraceptive pills and the risk of venous and arterial thrombosis: a systematic review. BJOG
2013;120:801-10.
45. de Bastos M, Stegeman BH, Rosendaal FR et al. Combined oral contraceptives: venous thrombosis. Cochrane Database Syst Rev 2014;3:CD010813.
46. Vinogradova Y, Coupland C, Hippisley-Cox J. Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the
QResearch and CPRD databases. BMJ 2015;350:h2135.
Prenatal and Postpartum Care
Carla Dillon, BScPharm, ACPR, PharmD

General Principles of Drug Use in Pregnancy and Breastfeeding

The management of common medical conditions during pregnancy and breastfeeding often includes self-medication. It can be a
therapeutic challenge to accurately determine the efficacy and safety of management strategies in this patient population. This
chapter provides an overview of the assessment and management of some common minor ailments encountered in pregnancy and
the postpartum period.
Many women are faced with the dilemma of how to best manage their medical conditions during pregnancy and breastfeeding and
few medications are officially approved for use during these times. When treating common medical conditions in a pregnant or
breastfeeding woman, the risks and benefits to the patient, fetus and nursing infant must be weighed carefully to help her make an
informed decision about medication use. Take care to provide accurate, current and relevant information in a calm, nonalarming
manner; provide the perspective that even if a woman does not take any medication during pregnancy, there is a baseline risk of 1–3%
for major fetal malformations.1,2 Table 1 and Table 2 provide some guiding principles for medication use during pregnancy and
breastfeeding.
3,4,5,6
Table 1: Principles of Recommending Drug Therapy to Pregnant and Breastfeeding Women
Recommend nonpharmacologic therapy first whenever feasible.
Determine the gestational or infant age. Risk posed by a drug may vary by pregnancy trimester. Premature and newborn
infants may be more vulnerable to drug effects.
Consider whether the benefits of drug therapy outweigh the risks.
Choose drugs with published data in pregnancy and breastfeeding over newer drugs with less information.
Choose the most effective agent with the most reassuring safety data in the lowest possible dose for the shortest possible
duration.
Choose single entity products to avoid unnecessary drug exposure.
Consider local application of drugs whenever possible to minimize systemic absorption.
Choose drugs with shorter half-lives whenever feasible to minimize medication exposure to the fetus/infant.
Any prolonged use of drug therapy (>3 days) should be approved by a healthcare practitioner.
Reassess if initial therapy for minor ailments fails to provide relief after 3 days.
Whenever feasible, schedule doses when the least amount of drug is anticipated to be in the breast milk (e.g., right after
breastfeeding or before the baby is expected to have a long sleep period). Drug diffuses from the milk back to the vascular
compartment as plasma drug concentration falls, so that the lowest levels in milk occur just prior to the next dose. Dosing in
this manner may not always be practical particularly when breastfeeding young infants who feed frequently and sleep for only
short intervals.
If several drugs are equally useful, select the drug that is excreted in breast milk in the lowest concentration with the least
effect on the infant.
3,4,5,6
Table 2: Myths and Facts Regarding Drug Therapy during Pregnancy and Breastfeeding
Myths Facts
“Women who are pregnant Although only a few medications are specifically indicated for use during pregnancy, many
should not take any medications are safe for use in pregnancy.7,8 Uncontrolled medical conditions can often
medications.” “Women should
pose a greater risk to a fetus than the treatment medication.9,10
stop their medications if they
become pregnant.”
Myths Facts
“The fetus is only susceptible The first 3 months of gestation may be the most critical in terms of fetal structural
to teratogenic effects from malformations, but functional and behavioural defects are also associated with later
drug therapy taken during the exposure. Teratogenic agents are defined as those that are capable of producing structural
first 3 months of pregnancy.” or functional abnormalities in the embryo or fetus.11
“This drug causes Animal data cannot always be extrapolated to human situations,5 e.g., erythromycin is
malformations in animals, so it considered a safe antibiotic to use in pregnancy, but it has been reported to cause
should not be used in
malformations in rats,8 and in contrast, thalidomide was found to be safe in most animal
pregnancy.”
models, but can cause limb defects in human fetuses.7
“Due to ease of availability, it Many nonprescription drugs require careful consideration of beneficial vs. harmful effects
can be assumed that or have limited safety data in those who are pregnant or breastfeeding.7,12
nonprescription drug therapies
are safe to use in pregnancy
and breastfeeding.”
“Due to ease of availability, In many cases, there is little reliable human data about the safety of natural health
natural health products can be products during pregnancy or breastfeeding, e.g., echinacea.12 Certain herbs such as blue
considered safe in pregnancy cohosh are specifically contraindicated due to empirical evidence that they can act as
and breastfeeding.”
abortifacients and cause cardiovascular defects.13 As with any other medicine, one must
weigh the risks and possible benefits of using natural health products during pregnancy.
Some natural health products may contain undeclared drugs or contaminants.
“If a drug is excreted in breast In many cases, only very low concentrations of drugs are present in breast milk and they
milk, it is contraindicated in a are still considered safe to use in breastfeeding.14 In general, taking drugs during
breastfeeding mother.” breastfeeding poses much less risk to the infant than drug therapy during pregnancy.
Healthcare practitioners should consult specific references to determine drug safety in
breastfeeding.
Prenatal Nutrition
Key Nutritional Recommendations in Pregnancy

Proper nutrition plays a very important role in a healthy pregnancy. Additional nutrients are needed to meet the needs of the
developing fetus (see Table 3).
Table 3: Key Nutritional Recommendations in Pregnancy

Nutrient Role in Daily Nonpharmacologic Pharmacologic Comments
Pregnancy Requirement Therapy Therapy
General Nutrient Eat a well-balanced Prenatal and Advise women not to
requirements are diet. See Canada's postpartum vitamin increase the dose of
increased due to Food Guide.15,16,17 If and mineral a multivitamin or
needs of the patient is not getting supplementation. take more than one
growing fetus. adequate nutrition When selecting a multivitamin as high
from diet, recommend multivitamin, the doses of vitamin A
dietary counselling. product should (>10 000 IU or
contain vitamin B12 in >3000 µg RAE per
addition to the day) can cause birth
ingredients discussed defects.16,17
below.16,17
Calcium Supports fetal 1000 mg for Eat foods high in Supplementation with May cause or
skeletal those calcium, e.g., dairy at least 1000 mg/day exacerbate
development. 19–50 y (plus products and calcium is recommended for constipation. High
Adequate intake vitamin D 600 fortified juices.20 those with a dietary rate of bone loss
reduces the risk IU); 1300 mg intake of less than during pregnancy
of hypertension for those 600 mg/day, e.g., less and breastfeeding,
and pre- <19 y (plus than 2 dairy thus adequate intake
eclampsia.18,19 vitamin D 600 servings/day.18,19 is essential for
Maintains IU)20,21,22 The upper limit of maternal bone
maternal stores. total daily intake is health.20 Calcium-
2500 mg for those based antacids can
19–50 y and 3000 mg have the dual
for those <19 y.21 benefits of calcium
supplementation
and heartburn
relief.20
Folic acida Essential for 0.4 mg Eat foods high in folic Supplementation with Women with
normal See acid (e.g., fortified 0.4 mg/day, in moderate risk of
development of Comments. grains, spinach, lentils, addition to dietary NTDb: 1 mg daily
fetal spine, brain chick peas, sources, is beginning at least 3
and skull. asparagus, broccoli, recommended for all months prior to
Reduces the risk peas, brussels women with child- conception and
of NTDs (e.g., sprouts, corn and bearing potential. continuing until 12
spina bifida, oranges). Diet alone is Start at least 2–3 wk gestational age,
anencephaly).16 unlikely to meet months followed by 0.4–1
Neural tube requirement.16 preconception, mg daily until 4–6
development continuing throughout wk postpartum or as
occurs early in pregnancy and for 4– long as
pregnancy 6 wk postpartum or breastfeeding
(during wk 3 and as long as
continues.23
4) when many breastfeeding
women may not continues.16,23 Women with high
be aware they risk of NTDc: 4 mg
are daily beginning at
pregnant.16,17 least 3 months prior
to conception and
continuing until 12
wk gestational age,
followed by 0.4–1
mg daily until 4–6
wk postpartum or as
long as
breastfeeding
continues.23
Iodine Increased 220–250 µg Eat foods with iodine, Supplementation with Sustained iodine
requirement as e.g., saltwater 150 µg/day intake >500–1100
iodine is seafood, milk. A suggested.27,29,30 µg/day should be
essential for teaspoon of table salt Avoid kelp/seaweed avoided due to the
fetal neurologic in Canada contains products as they may potential for fetal
development 380 µg of iodine. be contaminated with hypothyroidism.29
and to maintain Kosher, pickling and
heavy metals.27,31
maternal sea salt contain much
metabolism.24,25 less iodine.26
Processed foods
generally do not use
iodized salt.27,28
Iron Supports normal 27 mg Eat foods high in Supplementation with May exacerbate
fetal brain heme iron, e.g., meat, 16–20 mg/day is constipation, nausea
development poultry and fish. Eat recommended.17 and vomiting;
and builds fetal nonheme iron sources consider temporary
iron stores in the (e.g., fortified food, discontinuation in
third trimester. tofu, lentils, beans) the first trimester33
Lowers risk of with vitamin C- or intermittent
maternal containing foods. Diet dosing (e.g., 120 mg
anemia.32 alone is unlikely to once weekly) in
meet requirement.17 those who are not
anemic.34
a For simplicity the term folic acid is used interchangeably with folate. Folic acid is the synthetic form of the B vitamin which is found in fortified
foods and supplements. Folate is the natural form found in food.
b Moderate risk includes: maternal or paternal personal or family history of other folate-sensitive congenital anomalies (limited to specific
anomalies for cardiac, limb, cleft palate, urinary tract, congenital hydrocephaly); maternal or paternal family history of NTD in a first- or second-
degree relative; maternal diabetes; maternal kidney dialysis; maternal use of folate-inhibiting medications (carbamazepine, cholestyramine,
metformin, methotrexate, phenobarbital, phenytoin, primidone, sulfasalazine, triamterene, trimethoprim, valproic acid); maternal GI malabsorption
conditions (e.g., Crohn's disease, active Celiac disease, gastric bypass surgery).23
c High risk includes: maternal or paternal personal NTD history or a previous NTD pregnancy.23
Abbreviations: IU = international units; NTD = neural tube defect; RAE = retinol activity equivalent
.....
Pathophysiology
NVP is very common, occurring in about 70% of pregnant women. Approximately one third of pregnant women will experience nausea
without vomiting.35 Despite popular use of the term “morning sickness,” NVP persists throughout the day in the majority of cases.36
NVP usually appears by 4–6 weeks' gestation and disappears by 12–16 weeks; however, it can persist throughout pregnancy in up to
20% of cases.1,37,38 The nausea and/or vomiting is usually self-limiting and not associated with any adverse fetal outcome.39 Severe
vomiting resulting in significant maternal weight loss may increase the risk of low birth weight babies.39,40 Even less severe NVP can
negatively affect a woman's daily life. It can cause emotional, social and economic problems for the woman and her family.1,41
Although it occurs rarely, severe NVP, or hyperemesis gravidarum, may lead to dehydration, malnutrition and weight loss, requiring
hospitalization.1 Hyperemesis gravidarum affects on average 1% of pregnancies and is usually a diagnosis of exclusion.35,39 Onset is
nearly always in the first trimester, usually between weeks 6 and 8.40 Hyperemesis gravidarum may persist throughout the pregnancy,
but usually becomes less extreme as the pregnancy progresses. It tends to recur in subsequent pregnancies, so a previous history
makes the diagnosis more likely.39
The etiology of NVP is unknown, but it is postulated that multiple factors are involved. Hormonal changes, specifically first trimester
elevations of human chorionic gonadotropin (hCG), progesterone and/or estradiol have been implicated. Other proposed causes or
contributors include slower gastric emptying, Helicobacter pylori infection, psychological predisposition, genetic predisposition,
carrying a female fetus and evolutionary adaptation.1,41,42
Goals of Therapy
Reduce incidence and severity of NVP
Improve functioning and quality of life
Maintain adequate fetal and maternal nutrition
Prevent dehydration and significant weight loss
Reduce the risk of progression to more severe NVP
Minimize negative fetal effects from treatment
Patient Assessment
Counsel patients with adequate hydration and nutrition despite NVP on nonpharmacologic measures to relieve symptoms. Patients
with more severe nausea and vomiting with signs of dehydration or weight loss must be assessed immediately by a healthcare
practitioner. The Motherisk Pregnancy-Unique Quantification of Emesis (PUQE-24) scoring system can be used in assessing severity
and response to treatment.43 Information on NVP can also be found in Nausea and Vomiting.
Pregnant women can take many measures to alleviate NVP. Avoiding aggravating factors such as certain smells, fried or spicy food,
an empty stomach, stress and fatigue is key. Taking prenatal multivitamins and/or iron supplements after meals or at bedtime is also
suggested.39,42 If the size of the prenatal multivitamin or its iron content is an aggravating factor, consider temporarily stopping the
multivitamin, switching to a chewable multivitamin, or switching to multivitamin with no iron or a lower iron content.33 Intermittent iron
supplementation (e.g., once weekly) may also be considered in women who are not anemic34 (see Table 3). It is important to maintain
the recommended intake of folic acid; a folic acid supplement may be needed if the prenatal multivitamin is changed or temporarily
discontinued. Detailed information for patients on management of morning sickness is found in Morning Sickness—What You Need to
Know.
Acupressure at the Neiguan or P6 point, located 3 finger-widths up from the wrist crease, by use of wrist bands (e.g., Seabands) has
been used in the management of nausea and vomiting and appears to be safe in pregnancy.37,44 This method has shown varying
degrees of effectiveness; a short-term study found comparable efficacy to pyridoxine for mild to moderate symptoms.36,37,44
Products: Antiemetics; Vitamin and Mineral Products: Single Entity.
Antiemetics are indicated for the treatment of moderate NVP that fails to respond to nonpharmacologic interventions (see Table 8).
The therapy of choice in the management of NVP that is unresponsive to nonpharmacologic measures is Diclectin, a combination
delayed-release product containing the first-generation antihistamine doxylamine 10 mg and the B vitamin pyridoxine 10 mg.3,37,45,48
It is the only product with Health Canada approval for NVP. Over 33 million pregnant women worldwide have taken delayed-release
doxylamine with pyridoxine and it has not been found to increase the risk of teratogenesis or affect neurodevelopment.2,48,58 To
prevent early morning symptoms, 2 Diclectin tablets are taken at bedtime. One additional tablet can be taken in the morning and
midafternoon to control daytime nausea. Due to its delayed release, tablets should be taken on a regular basis and not on an as
needed basis.48 Supratherapeutic doses (up to 12 tablets per day) may be needed by some women and appear safe, but evidence is
limited to small studies.38,59 Due to the antihistamine component the most common adverse effect of Diclectin is drowsiness. On
discontinuation, Diclectin should be gradually tapered to prevent sudden recurrence of NVP symptoms.48
Pyridoxine, also known as vitamin B6, is a component of Diclectin. In the United States, pyridoxine monotherapy is the recommended
first-line pharmacologic option for NVP.37,60 Pyridoxine can be used in combination with other drug therapies (e.g., dimenhydrinate).41
Although case reports sparked concern that taking pyridoxine during pregnancy might cause seizures in some newborns, further
investigation suggests the infants had an underlying vitamin B6 deficiency disorder which was unmasked when maternal
supplementation was stopped.54
Dimenhydrinate is a second-line treatment option but may be preferred when oral drug administration is not possible.1,39,45 If the
patient is vomiting frequently, it can be given orally or rectally 30 or 45 minutes before a dose of Diclectin.1,41
Ginger (Zingiber officinale) traditionally has been used in many forms (e.g., ginger tea, ginger ale, gingersnaps and powdered ginger
root) to alleviate nausea. Powdered ginger root is the form of ginger most commonly used in studies. Small randomized, controlled
trials indicate ginger reduces nausea and vomiting of pregnancy and its efficacy is at least comparable to that of dimenhydrinate and
pyridoxine.36,49,50,51,52,61 However, replicating this effect in practice is hindered by the lack of description of the composition of ginger
used and lack of standardization of many ginger products.62 The usual dose is up to 1000 mg per day.41 Licensed NHP ginger
products are available (e.g., Gravol Ginger). Ginger does not appear to be teratogenic and is generally considered safe during
pregnancy. However, there are limited data on fetal effects with ginger supplementation.63,64,65
Information regarding efficacy and safety is lacking for other traditional remedies such as peppermint, raspberry leaf and chamomile.
Other agents that have been used in the treatment of nausea and vomiting during pregnancy include metoclopramide, ondansetron,
phenothiazines (e.g., chlorpromazine, promethazine, prochlorperazine) and methylprednisolone. These agents are used as
monotherapy or adjunctive therapy after inadequate response to Diclectin.41,60 Metoclopramide and phenothiazines are not
teratogenic but can cause extrapyramidal effects in the mother, and in the newborn if given near term. Safety data for ondansetron are
conflicting. Due to its potential to cause QT prolongation, cleft palate and fetal heart defects, use should be limited to after 10 weeks'
gestation. Similarly, methylprednisolone use should be delayed until after 10 weeks' gestation due to possible association with cleft
palate.41
.....
Allergic Rhinitis during Pregnancy and Breastfeeding
Pathophysiology
Rhinitis affects at least 20% of pregnancies.66 Common symptoms of allergic rhinitis include nasal itchiness, clear watery rhinorrhea
and sneezing.66 Hormonal changes in pregnancy can worsen nasal symptoms and can induce a form of rhinitis, termed “rhinitis of
pregnancy,” which presents as congestion and occurs in the absence of other signs of respiratory tract infection or a known allergic
cause. Rhinitis of pregnancy occurs in approximately 9% of pregnancies and usually begins later in the pregnancy but can start at any
time, with resolution of the syndrome within 1–2 weeks postpartum.67,68,69,70 More information can be found in Allergic Rhinitis.
Goals of Therapy
Relieve symptoms
Improve functioning and quality of life (e.g., improve sleep)70
Minimize risk of complications such as sinusitis and aggravation of pre-existing asthma
The mainstay of nonpharmacologic management of allergic rhinitis during pregnancy is minimizing exposure to allergens, such as
pollen, animal dander, dust mites or mold growth, and remaining indoors when necessary. Avoiding exposure to irritants such as
cigarette smoke, smog and strong odours is also important. For both allergic and pregnancy-induced rhinitis, nocturnal congestion
may be temporarily relieved by elevating the head of the bed and/or use of external nasal dilators (e.g., Breathe Right nasal strips).70
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Cough, Cold and
Allergy Products.
Therapies for allergic rhinitis and the common cold are outlined in Table 9.
Due to its local application and lack of toxicity, irrigation via nasal saline sprays, mists or washes is a recommended sole or adjuvant
therapy in providing symptom control to irritated nasal passages during pregnancy.66,67,68,69,112
Antihistamines are first-line agents in the treatment of allergic rhinitis.69 During pregnancy, first-generation antihistamines are
considered safe; chlorpheniramine is considered an agent of choice for allergic rhinitis.3,67,76 Caution is advised with usual or high-
dose first-generation antihistamine therapy near the end of term due to the potential for withdrawal effects in the newborn and
retinopathy of prematurity, particularly in low-birth-weight newborns.67 The second-generation antihistamines loratadine,
desloratadine and cetirizine are also considered safe during pregnancy; fexofenadine can be considered as an alternative (due to less
available safety data).70,76,80,113,114,115,116 First- or second-generation antihistamines may be used safely during
breastfeeding.76,117,118,119,120 Second-generation antihistamines are sometimes preferred during breastfeeding due to their lower
potential to cause adverse effects in the infant, reduced milk production, sedation or anticholinergic effects compared with first-
generation antihistamines.72
Decongestants can be utilized supplementally for additional symptom relief, if nasal saline fails. Systemic pseudoephedrine is
generally considered safe to use during pregnancy; however, first-trimester use may cause a small increased risk of abdominal wall
and intestinal defects.12,75,102,104 Phenylephrine is more likely than pseudoephedrine to have vasoactive effects such as
hypertension and reduced uterine blood flow (though not reported in humans), and is reserved as an alternative to
pseudoephedrine.101,102,103,121,122,123 First-trimester use of phenylephrine has been associated with congenital defects (mostly
minor), but further data are required.103,102 Although topical decongestants have lower systemic absorption, evidence is limited
regarding use during pregnancy.12,75,102,108,124,125 First-trimester use of decongestants should be avoided if possible.70,102,104
Intranasal sodium cromoglycate (cromolyn sodium) is considered a first-line treatment option for allergic rhinitis during
pregnancy.67,69,80 It is well tolerated with few adverse effects and is considered safe in pregnancy and breastfeeding due to minimal
absorption across nasal membranes.6,67,72
Intranasal corticosteroids are reserved for allergic rhinitis symptoms unresponsive to antihistamines, decongestants and/or sodium
cromoglycate.69 Information regarding the efficacy of intranasal corticosteroids in rhinitis of pregnancy is limited to a single study
where no benefit was found.70,126 Inhaled corticosteroids are widely used in the treatment of asthma during pregnancy, particularly
beclomethasone, budesonide and fluticasone.66,67,80 Systemic absorption is minimal; more safety information is available for
inhaled/intranasal budesonide.67,80,127 The majority of data indicate no association with an increased risk of congenital abnormalities
with low to moderate doses;128 however, a small associated risk may exist between intranasal budesonide and cardiac defects, and
between inhaled budesonide and orofacial clefts.96 Minimize exposure when feasible, particularly during the first trimester.89,96 Data
are limited on the safety of intranasal corticosteroids during breastfeeding. They may be excreted into breast milk in small quantities;
however, it is unlikely to be clinically significant and they are generally considered compatible with breastfeeding.6,72,96
The antileukotrienes zafirlukast and montelukast have been used in the treatment of allergic rhinitis after other treatments have
failed. Harmful effects have not been seen in animal studies but human pregnancy data are limited and use should be limited to cases
where the benefit clearly outweighs risk.67 Safety of these agents in breastfeeding has not been established.6,67,72
Allergen immunotherapy can be continued during pregnancy. However, to reduce the risk of a severe allergic reaction, it should not be
initiated during pregnancy nor should the strength of the allergen be increased.67,80 No data are available for safety in breastfeeding;
however, it is unlikely to pass into breast milk and it is considered safe to continue breastfeeding.6
For more information on further therapy, see Allergic Rhinitis.
.....
Other Common Conditions in Pregnancy
Other Common Conditions in Pregnancy

Table 4 describes the management of some conditions commonly encountered in pregnancy. Many conditions are covered in detail in
specific chapters as outlined in the endnotes. See also Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions.
Information regarding therapy for depression in pregnancy is discussed in conjunction with therapy of postpartum depression (see
Pharmacologic Therapy in Postpartum Depression section).
Table 4: Management of Selected Common Conditions in Pregnancy

Condition Cause Nonpharmacologic Pharmacologic Therapya Monitoring of Comments
Therapy Therapy
Backacheb, Back muscles Backache, pelvic Acetaminophen is the drug of Reassess if ASA (at analgesic
under strain due to pain: Relaxation choice.5,12 Limit codeine to symptoms are doses), ibuprofen
Headachec, growing abdomen. exercises; massage; short-term use in pregnancy. severe or do and naproxen have
Pelvic pain Weight of uterus rest in recumbent High doses of codeine close to not improve not been associated
can contribute. position; good term or prolonged use during after 5 days. with congenital
Headache posture and lifting pregnancy can cause neonatal With codeine, malformations in the
commonly results techniques; majority of
opiate withdrawal.87 monitor
from muscle moderate exercise patient for studies.131,132,133
tension.129 (land- or water- adverse However, areas of
based); pelvic tilts; effects such controversy exist
elevation of one leg as (small, possible
while standing; constipation increased risk of
acupuncture.129,130 or drowsiness inhibition of egg
Headache: Cool wet and reassess implantation,131
if adverse gastroschisis132 and
cloth to forehead.129
effects are
intolerable. cardiac defects134
with first-trimester
exposure; premature
closure of ductus
arteriosus and fetal
renal problems with
use in the last 8 wk
of pregnancy131 and
maternal bleeding
during
delivery).12,75,131
Patient must be
assessed by
appropriate
healthcare
practitioner
immediately if
headache is severe
and/or associated
with blurred vision or
nausea/vomiting as
this may be a sign of
hypertension or
preeclampsia.129,131
Therapy Therapy
Common Viral Bedrest; maintain Many products contain more Reassess if Avoid use of
Coldd fluid intake; humidify than 1 ingredient. Use single- symptoms are vitamins and
air; hard candy for a ingredient products where associated minerals for cold
sore throat; possible to minimize exposure with fever, symptoms (e.g., zinc
saltwater to unnecessary drugs. Avoid nausea or lozenges, vitamin C)
gargle.12,135 alcohol-containing products. vomiting. beyond those in
prenatal
multivitamins as
higher doses lack
safety information
and may exacerbate
other pregnancy
conditions, e.g.,
nausea.12 Avoid
echinacea
due to limited data
in pregnancy and
lack of
standardization of
product content.12
Therapy Therapy
Constipatione Reduced GI motility Dietary: Eat foods Regular use of bulk laxatives Reassess if Avoid mineral oil
due to increased high in fibre, e.g., such as psyllium and/or stool symptoms do and castor oil as
progesterone whole grains, softeners such as docusate, not improve they may interfere
levels. Other vegetables, fruits, which are poorly absorbed, can after 5–7 with absorption of
factors: high fibre cereals. be used for prevention. Since days. fat-soluble vitamins
compression of Add fibre to diet these agents take several days such as vitamin K
intestines by slowly to prevent to work, other agents may be (could decrease
enlarging uterus, bloating and needed for acute management. availability to
increased water gas.136,137 The Docusate has questionable fetus).141 Castor oil
resorption by suggested adequate efficacy.139 Consider dosage may stimulate
colon, iron and fibre intake during reduction or temporary uterine contractions
calcium pregnancy is 28 discontinuation of iron and result in
supplementation supplements in those without bleeding, abortion or
g/day.138 Increase
and reduced uterine
fluid intake, e.g., 6–8 anemia.140
physical activity.
glasses of water For acute treatment: glycerin rupture.141,142
Occurs in 10–40%
of daily.136,137,139 suppositories, PEG, and senna— Lactulose is poorly
pregnancies.136,137 Lifestyle: Regular generally, these agents have absorbed and
Can exacerbate moderate limited study data, but are poorly considered
absorbed and considered compatible with
nausea. exercise.136,137,139
compatible for as-needed, short- pregnancy; however,
term use during its sweet taste may
pregnancy.136,137,143 144 exacerbate nausea.
Use of osmotic
laxatives (e.g.,
sodium phosphate,
magnesium
hydroxide) is
generally
discouraged as
other options are
less likely to cause
electrolyte
imbalances.141
Regular use of
osmotic laxatives
such as lactulose or
stimulant laxatives
such as bisacodyl
can result in
excessive fluid and
electrolyte loss;
therefore,
monitoring,
adequate hydration
and a balanced diet
are important.137
Therapy Therapy
Hemorrhoidsf Increased venous Dietary: Prevent Regular use of bulk laxatives Monitor for Ointments or
pressure below the constipation and such as psyllium and/or stool allergic suppositories
uterus; straining, e.g., softeners such as docusate) reactions, containing topical
constipation and increase dietary may relieve some discomfort which for anesthetics (e.g.,
associated chronic fibre and fluids. (see constipation topical rectal benzocaine,
straining; vessel Lifestyle: Maintain above).137,141,142 Of the rectal products may pramoxine),
walls relaxed by normal bowel agents, external products resemble vasoconstrictors
progesterone (can function. Apply ice preferred due to minimal hemorrhoid (e.g., epinephrine) or
lead to pack or cold absorption (unless the skin is symptoms. hydrocortisone
swelling).137,142 compress to help chafed). Those inserted into Topical should be used only
Occurs in 25–35% relieve itching. Keep rectum may be readily absorbed astringents under supervision of
anal area clean to from rectal mucosa. A skin can sting and a healthcare
of pregnancies.142
avoid irritation by protectant (e.g., petrolatum) can exacerbate practitioner due to
cleaning with soap be used to prevent further skin symptoms.141 possible systemic
and water after each damage. Reassess if absorption with
bowel movement symptoms do consequent effects
and drying area by Although lacking data in on the fetus.
pregnancy, short-term use of not improve
dabbing (not after 5–7 Avoid
wiping). Use a warm topical astringents (e.g.,
hamamelis, zinc sulfate) can be days. vasoconstrictors in
water sitz bath for those with
10–15 min or soak used to clean and soothe the
hemorrhoid area. hypertension.
in a warm water
bath as needed for Acetaminophen may be used for Reassess if severe
comfort. Sit on an pain, protrusion,
pain relief.137,142
air doughnut to bleeding or fecal
relieve discomfort seepage.137
from
pressure.137,142
Pigmentary Cause of this facial Can be initiated and Broad-spectrum sunscreen is Monitor for Usually resolves
changes skin exacerbated by sun used in prevention and skin redness, after pregnancy.
(melasma, hyperpigmentation exposure. Avoid management.145 Recommend burning, However, up to 30%
chloasma, disorder is excessive exposure irritation, of cases may be
an SPF of at least 30.146
mask of unknown. Risk to sunlight.145 unusual skin persistent.149
pregnancy) factors include Topical hydroquinone 2–4% discolouration.
darker skin types, applied BID to the affected areas May reoccur and
genetic disposition, may be effective. However, data darken with
exposure to UV in pregnancy are limited and subsequent
light, pregnancy, systemic absorption does occur. pregnancies.150
oral hormonal Suggest limiting use to severe
contraceptives and cases under medical
underlying thyroid supervision.147,148
disorders.145 Effectiveness of hydroquinone is
enhanced by concurrent use of
broad-spectrum sunscreen.146
Therapy Therapy
Reflux Decreased Dietary: Eat small Calcium-containing antacids Monitor for Avoid ASA (e.g.,
Esophagitisg pressure or blunted frequent meals; eat may be used. Space doses apart heartburn, Alka-Seltzer). See
response of the slowly; avoid foods from iron-containing regurgitation Backache,
lower esophageal that cause supplements. Do not exceed and nausea as Headache, Pelvic
sphincter caused heartburn; eat in an recommended doses. well as other Pain row.
by hormonal upright position; Magnesium- or alginic acid- signs and Avoid sodium
changes. Other drink warm milk; containing antacids as well as symptoms of bicarbonate due to
factors likely avoid oral intake the H2 antagonists ranitidine heartburn. short duration of
contribute. Usually (other than water) Reassess if effect, possible
and famotidine are also safe
1st reported in within 3 h of going symptoms do rebound symptoms
to bed. Lifestyle: options.152 not improve
early pregnancy.151 and metabolic
Elevate the head of Proton pump inhibitors can be after 7 days alkalosis with
Predominant
the bed using used when other therapies have and/or if a H2
symptoms are
blocks, or use 2 chronic use.136,143
failed (omeprazole is the most receptor
heartburn and
extra pillows to raise studied in antagonist is Avoid magnesium
regurgitation which
the head; lay on the pregnancy).136,137,153,154,155,156 required. trisilicate due to
are aggravated by
left side of the body; association with
meals and lying
avoid stooping, fetal nephrolithiasis,
down.136 Occurs in bending or hypotonia,
30–80% of assuming other respiratory distress
cases.137 positions that tend and CV
to worsen reflux; impairment.136,143
chew
gum.129,136,137,151
a Use the lowest effective dose for the shortest duration possible. Short-acting formulations are generally preferred to minimize fetal exposure
time. Avoid alcohol/ethanol-containing liquid formulations. Consider the risk vs. benefit for each individual, including any risk associated with
under-treating a maternal condition.
b
For more information, see Low Back Pain.
c For more information, see Headache.
d For more information, see Viral Rhinitis, Influenza, Sinusitis and Pharyngitis.
e For more information, see Constipation.
f For more information, see Hemorrhoids.
g For more information, see Dyspepsia and GERD.
Abbreviations: ASA = acetylsalicylic acid; CV = cardiovascular; GI = gastrointestinal; H2 = histamine 2; NSAID = nonsteroidal anti-inflammatory
drug; PEG = polyethylene glycol; PPI = proton pump inhibitor; UV = ultraviolet
.....
Vaccinations during Pregnancy and Breastfeeding
Vaccinations during Pregnancy and Breastfeeding

Immunization during pregnancy or breastfeeding can provide the dual benefit of protecting the mother and the fetus/newborn by
eliminating the mother as a source of disease transmission as well as transmitting protective levels of maternal antibodies
transplacentally or via breast milk. Inactivated or toxoid vaccines can be given to pregnant women when indicated. However, live
vaccines are generally contraindicated during pregnancy due to the theoretical risk of transmitting the disease to the fetus. Most
vaccines can be given to breastfeeding women with the exception of those vaccines that may pose a risk of transmitting the disease
to the infant (e.g., Bacille Calmette-Guérin vaccine, smallpox vaccine, yellow fever vaccine).157 More information on the use of
selected vaccines during pregnancy and breastfeeding can be found in Table 5.
Table 5: Use of Selected Vaccines during Pregnancy and Breastfeeding

Vaccine Use during Pregnancy Use during Breastfeeding Comments
Hepatitis A Recommended when indicated (e.g., close contact with a person with
hepatitis A, or travel to an endemic area).158
Hepatitis B Recommended when indicated (e.g., ongoing exposure risk).159

Vaccine Use during Pregnancy Use during Breastfeeding Comments
Influenza Recommended in all patients at any Recommended in all patients.160 Live attenuated influenza
(inactivated) stage of pregnancy. vaccine is not
Associated with reduced maternal recommended during
and newborn influenza-related pregnancy but may be
morbidity. used during breastfeeding
when indicated.160
The risk of influenza-related
hospitalization increases with
gestation.160
Meningococcal Recommended when indicated (e.g., travel to a high-risk area, postexposure

conjugate prophylaxis or during an outbreak).161
Pertussis Recommended in those ≥26 weeks' Recommended to be given as early Available only as a
(acellular) gestation if not previously as possible postpartum if pertussis combination vaccine
vaccinated against pertussis in vaccine not previously received in (Tdap recommended).
adulthood, or during local pertussis adulthood.162 The greatest morbidity
outbreak, irrespective of and mortality from
immunization history.162 pertussis occurs in
children <6 months.162
Pneumococcal Recommended when indicated (e.g., those with underlying medical

polysaccharide conditions such as asthma, diabetes mellitus).163
or conjugate
Tetanus toxoid Recommended when indicated (postexposure prophylaxis).164
Abbreviations: Td = tetanus diptheria; Tdap = tetanus, diptheria and acellular pertussis
.....
Use of Common Substances/Products during Pregnancy
Use of Common Substances/Products during Pregnancy

Information on the use of some common substances/products during pregnancy can be found in Table 6.
Table 6: Use of Common Substances/Products during Pregnancy

Recommendation
Substance/Product Comments
in Pregnancy
Alcohol Avoid use.165 Regular use of alcohol or exposure to high levels of alcohol, can cause fetal
harm (fetal alcohol spectrum disorder). The amount of exposure required to
cause harm is unclear; therefore, abstinence is recommended.165,166
The Alcohol and Substance Use Helpline (1-877-327-4636) provides patients
and healthcare practitioners with information and counselling on alcohol and
recreational substance use during pregnancy and breastfeeding.
Caffeine Consume ≤300 Conflicting data on the potential for harm (e.g., small for gestational age) with
mg/day. consumption >300 mg/day.167,168 Average amounts of caffeine in common
drinks and foods can be found on the Public Health Agency of Canada's
website.169
Cigarette smoking Avoid use and Associated with a number of negative effects (e.g., spontaneous abortion,
exposure to preterm labour, small for gestational age, sudden infant death syndrome,
second-hand childhood respiratory problems).
smoke. If cessation is unsuccessful after education and behavioural therapy, use of
smoking cessation medications should be considered.170,171,172
Prevention of Gestational and Neonatal Exposure to Tobacco Smoke
(PREGNETS) website (www.pregnets.org) provides information and support
for those trying to quit smoking during pregnancy and breastfeeding.
See also Tobacco Use Disorder: Smoking Cessation.
Recommendation
Substance/Product Comments
in Pregnancy
Hair treatments (e.g., Occasional hair Limited human data are available. Based on animal data, minimal systemic
bleaching, colouring, treatments unlikely absorption and lack of reports of fetal harm, having hair treatments 3–4 times
straightening) to pose a risk. during pregnancy at 6- to 8-wk intervals is unlikely to pose a risk to the
fetus.173,174
.....
Postpartum Perineal Care and Postepisiotomy Pain
Pathophysiology
The perineum is a diamond-shaped area between the vagina and the anus.175 A Canadian study found 92% of women who had a
vaginal delivery experienced perineal pain on the first day postpartum. A week later 61% reported pain and by 6 weeks postpartum
only 7% reported perineal pain.176 Perineal pain results from trauma to the area as a result of bruising, tearing, episiotomies
(enlargement of the vaginal orifice by surgical cutting of the perineum to facilitate delivery) and/or use of a vacuum or forceps to
assist delivery.175,177 The perineum is an extremely tender site for a cut or stitches and women report a wide range of pain, from mild
to excruciating.176 Perineal pain can cause reduced mobility, discomfort during urination or defecation, urinary and fecal incontinence,
discomfort while sitting, and sexual dysfunction, and can interfere with providing newborn care.178,179 The degree and duration of
pain are related to the intensity of the trauma. Those who had episiotomies and more extensive tearing (third or fourth degree tears),
reported perineal pain at 6 weeks at a rate of 13% and 20% respectively.176 In contrast, pain resolved within 2.5 weeks for those with
an intact perineum or minor tears.180
Goals of Therapy
Relief of perineal pain
Prevention of complications such as infection
Patient Assessment
When perineal pain is severe or associated with foul-smelling discharge, burning, bleeding or high fever, the patient should be
assessed by an appropriate healthcare practitioner immediately.
Nonpharmacologic measures to relieve symptoms and help with perineal healing include localized cooling,178,181 Kegel exercises and
rinsing the area with warm water from a perineal squirt bottle after using the toilet. Detailed information for patients on perineum care
can be found in Care of the Vaginal Area (Perineum) after Childbirth—What You Need to Know.
Products: Internal Analgesics and Antipyretics; Skin Care Products: Anesthetics.
Short-term relief of perineal pain can be obtained using a local agent (see Table 10). Wipes containing hamamelis (witch hazel) may
reduce pain and itching.180 Topical anesthetic products containing lidocaine are also available but should be used only under the
direction of a healthcare practitioner due to the risk of systemic absorption from the area of trauma. The efficacy of topical
anesthetics for perineum pain is unclear due to lack of evidence.187 Nonopioid analgesics such as acetaminophen, ibuprofen and
naproxen sodium are first-line oral medications for pain in breastfeeding women.188,189,190 NSAIDs (e.g., ibuprofen, naproxen sodium)
may provide similar efficacy to codeine/acetaminophen products and do not cause constipation.190 Opioid analgesics such as
codeine were initially considered compatible with breastfeeding; however, depending on ethnicity, 1–29% of the population are
ultrarapid metabolizers of CYP2D6, which results in increased conversion of codeine to morphine.88,89,90,191 A case report in 2006 of
an infant death related to ultrarapid metabolism of codeine by the breastfeeding mother sparked concern regarding the safety of
codeine use.191 If a codeine product is deemed necessary, use the lowest effective dose and limit use to a maximum of 4 days if
possible. Closely monitor mother and infant for signs of opioid toxicity, e.g., sedation, lethargy and poor milk intake by infant.88,192
.....
Postpartum Depression
Pathophysiology
Pathophysiology
Postpartum blues (“baby blues”) is common, occurring in 15–85% of new mothers.193 Symptoms generally begin sometime in the
first week after delivery and may include sadness, insomnia, tearfulness, irritability, fatigue, anxiety and poor appetite. Postpartum
blues has only a minimal effect on the mother's ability to function and is transient, resolving spontaneously within 1–2 weeks.193,194
The cause is unknown, although hormonal changes after delivery are believed to play a role. Postpartum blues usually does not
require therapy due to its transient course.
Postpartum depression (PPD) occurs in approximately 13% of new mothers.195 In contrast to the baby blues, PPD is more disabling;
the mother often finds it difficult to take care of her infant and herself. PPD is also more persistent, lasting longer than 2 weeks. The
incidence is highest in the first 3 months postpartum with peak onset in the first 4–6 weeks, but may occur anytime in the first 6
months after delivery. The symptoms are the same as for major depressive disorder and can include lowered energy, difficulty
concentrating, severe anxiety, feelings of worthlessness or guilt, disturbed sleep and changes in appetite. Maternal attitudes toward
the infant are highly variable but can include disinterest, fear of being alone with the infant or excessive intrusiveness that inhibits
adequate infant rest.196 Thoughts of self-harm or suicide can also be present. The etiology may be complex and include biologic and
psychosocial factors.193,194
PPD may result in the mother feeling too unwell to initiate or maintain breastfeeding. Untreated PPD can also result in impaired child
development and is associated with poor cognitive functioning, behavioural inhibition and emotional maladjustment in infants and
children.193
For more information on depression see Depression.
Goals of Therapy
Relieve depressive symptoms
Identify patients at risk of postpartum depression
Educate patients on recognizing danger signs
Patient Assessment
Postpartum women should be monitored carefully by their healthcare practitioners. The diagnosis may be difficult to make since
changes in sleep, appetite and energy are routine with the arrival of a new baby. The Edinburgh Postnatal Depression Scale is a
validated and readily available screening tool consisting of 10 multiple choice questions to be answered by the new mother.193,194 A
brief patient information sheet with a checklist is provided in Postpartum Depression—What You Need to Know. If any of the signs on
the checklist apply to a postpartum patient, strongly advise her to seek help by immediately referring her for counselling and/or
specialized mental health treatment, and encourage completion of the more specific Edinburgh scale.
Psychotherapy may be effective for some women suffering from PPD. Specifically, supportive counselling, cognitive behavioural
therapy, interpersonal therapy and psychodynamic therapy have shown benefit.195 However, psychotherapy may not be an option for
some women due to cost, lack of a therapist in the area and difficulty arranging child care to attend sessions.193 Some women may
receive benefit from light therapy, peer support groups and/or regular exercise.
For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments—Herbal and Natural
Health Products: Single Entity; Vitamin and Mineral Products: Single Entity.
St. John's wort has been used in the treatment of mild to moderate depression. Information in breastfeeding is conflicting ranging
from reports of no adverse effects in infants to reports of jaundice, colic, drowsiness and lethargy.6,197,198 St. John's wort can interact
with many other medications as it induces CYP3A4, including reducing the effectiveness of oral contraceptives.197 Due to the
variability in composition of products and potential for drug interactions, other treatment options are preferred. Use during pregnancy
should be avoided as there are insufficient human or animal data.198,199 If a pregnant woman chooses to use St. John's wort,
encourage enrollment in the Motherisk St. John's wort study (1-800-670-6126; www.motherisk.org).
Omega-3 fatty acid supplementation has been investigated for treating depression. Randomized controlled trials have not shown a
benefit over placebo in postpartum women; however, studies have been limited by small sample size and variation in the dose of
omega-3 used.193,199 Although omega-3 supplementation cannot presently be recommended for perinatal depression, women should
be encouraged to meet dietary intake requirements to aid in normal fetal and infant development.
The safety and efficacy of S-adenosyl-methionine (SAMe) for treating postpartum depression and depression during pregnancy have
not been established; its use should be avoided.199,200 Folic acid has been found to augment antidepressant efficacy, but has not
been specifically studied in perinatal depression; doses beyond routine supplementation cannot be recommended (see Table 3).199
Women who are breastfeeding may prefer psychotherapy over medication; however, it may be less effective than medication for
severe depressive symptoms. PPD generally requires medication and possibly hospitalization to prevent suicide or infanticide.
Antidepressants pass into breast milk but usually do not produce adverse effects in the infant. Monitor the infant for irritability,
sedation, poor weight gain and change in feeding patterns.193 The choice of antidepressant should be based on the woman's
symptoms and history of antidepressant use. Treat for a minimum of 9 months.194
For further information on pharmacotherapy of depression, see Depression.
.....
Postpartum Contraception
Introduction
Most healthcare practitioners suggest waiting about 4–6 weeks before resuming intercourse, to allow the woman's body to heal. The
uterus and vagina must return to their prepregnancy size, a process that usually occurs more quickly in breastfeeding women.
Many variables such as fatigue, postpartum depression and decreased sex drive can influence this time frame. Many women take
much longer before they feel like resuming intercourse; however, surveys indicate a significant number choose to resume intercourse
before 6 weeks.201 Couples need to make individual decisions based on comfort level.
Ovulation usually resumes within 4 weeks after delivery in nonlactating mothers. In breastfeeding mothers, the onset of ovulation is
delayed but more variable as it is influenced by the extent of breastfeeding.201
The choice of contraceptive method is highly individual. Discussion of the pros and cons of various methods should begin during the
last trimester of pregnancy to provide sufficient time to make an informed choice. Contraception should be initiated in the third
postpartum week.201,202 Some long-term contraceptive methods should not be started before 6 weeks postpartum; other options
(e.g., barrier methods, progestin-only contraceptives) may need to be used in the interim (see Other Nonhormonal Methods and
Hormonal Contraceptives).
Lactational Amenorrhea Method (LAM)

The lactational amenorrhea method (LAM) uses breastfeeding as a contraceptive method. LAM can be as effective as oral
contraceptives; however, it is influenced by a number of factors that may make this an impractical method for many women. For LAM
to be effective, the mother must breastfeed at regular intervals (no greater than 4 hours during the day or 6 hours at night) and must
exclusively breastfeed (supplemental food should be no greater than 5–10% of total feedings).203 Expressing milk by pump is less
vigorous than suckling and may reduce the efficacy of LAM. Even with full breastfeeding and adequate milk production, frequent
suckling is believed to be necessary to achieve the full contraceptive effect of LAM.204 After 6 months or when menstruation resumes,
the risk of ovulation increases and thus the efficacy of LAM declines.203 Some suggest an additional form of contraception be started
in the third postpartum month.201
Other Nonhormonal Methods

Barrier methods include male and female condoms, sponges, diaphragms and cervical caps, all supplemented by spermicides. Male
condoms can be used almost immediately postpartum and can be a good short-term option for those waiting for initiation of a more
long-term method. Lubricated condoms can help offset vaginal dryness experienced by some women postpartum.202
Diaphragm and cervical cap fitting or refitting should be performed 6–8 weeks after delivery, to allow for completion of uterine
involution.201 The sponge may have a higher failure rate among women who have delivered a child than among women who have not,
even with perfect use.202,205 To decrease the risk of toxic shock syndrome, contraceptive sponges, cervical caps and diaphragms
should not be used while there is continued postpartum bleeding.201,202 The lower effectiveness of barrier methods compared with
intrauterine and hormonal options should be considered when choosing a method.206
A copper intrauterine device (IUD) can be inserted between 10 minutes and 48 hours postpartum. If this window is missed, wait until
>4 weeks postpartum (due to risk of expulsion).207,208 Although there may be a small increased risk of uterine perforation if IUD
insertion occurs while breastfeeding or if <36 weeks postpartum,209 benefits are considered to outweigh risks.207,208 Copper IUDs
have no known effect on lactation.201,202,206
For more information on barrier contraceptive devices, see Contraception.
Hormonal Contraceptives
For more information on hormonal therapy, consult the Compendium of Therapeutic Choices: Contraception
Postpartum use of combination estrogen-progestin contraceptives is restricted due to increased risk of venous thromboembolism
(VTE) and possible negative effects on breastfeeding.210 However, after 6 weeks postpartum an estrogen-progestin contraceptive can
be initiated.203,210
The risk of VTE postpartum is estimated to be 22- to 84-fold greater than that of nonpregnant, nonpostpartum females.211 This risk
steadily declines postpartum and within 6 weeks most women have returned to their pre-pregnancy risk.201,211 As estrogen-progestin
contraceptives independently increase risk of VTE, it is recommended to delay their initiation until more than 6 weeks
postpartum.203,210 Earlier use (>3 weeks postpartum) may be considered in select, low-risk women.210
Whether to initiate combined estrogen-containing contraceptives in those who are breastfeeding is an area of controversy. Estrogen
has the potential to reduce lactation; however, studies in this area are generally of poor quality and data are lacking with the low-dose
estrogen products.202,212 It is recommended to wait at least until breastfeeding is well established (at least 4–6 weeks
postpartum).202,203,210
Progestin-only contraceptives (oral progestin, medroxyprogesterone depot injection and levonorgestrel intrauterine device) are
generally initiated 4–6 weeks postpartum in breastfeeding women. This time frame is based on the paucity of high-quality data for
earlier use and the theoretical concern that neonates are unable to effectively metabolize progestins in breast milk.202,203,210,213
However, due to the lack of evidence of negative effects on breastfeeding or infant growth and development, guidelines indicate use
of progestin-only contraceptives can be considered earlier than 30 days postpartum.210,213,214,215,216 Although there may be a small
increased risk of uterine perforation if IUD insertion occurs while breastfeeding or if <36 weeks postpartum,209 benefits are
considered to outweigh risks.207,208
.....
Drug Therapy during Breastfeeding
Drug Therapy during Breastfeeding

Nearly all drugs will be present in breast milk to some degree following maternal ingestion.6 Many lists of drugs that are acceptable to
ingest during breastfeeding have been developed, but they differ and are based on subjective interpretation of data. Most of the
published data come from single case reports, and reports of drug concentration in breast milk are often based on single dose
measurements, not accounting for effects of drug accumulation.11 Therefore, it is difficult to interpret the clinical significance of this
information. Additionally, a drug's effect on milk production is an important consideration. Refer to Table 1 for general principles of
drug therapy during breastfeeding.
Table 7 outlines some information pertaining to common medication use during breastfeeding. See also Pregnancy and
Breastfeeding: Self-care Therapy for Common Conditions.
a
Table 7: Common Medications Usually Considered Compatible with Breastfeeding
Drug Class Comments
Acid Limited data available. Calcium-containing antacids are preferred as they have the additional benefit of
suppressors replacing maternal calcium lost during breastfeeding. Magnesium-containing antacids, alginic acid and
sucralfate are poorly absorbed thus unlikely to produce effects in a breastfed infant.151 H2-antagonists
are considered compatible; famotidine is preferred as it concentrates in breast milk to a lesser degree
than ranitidine or cimetidine and has more safety data than nizatidine.6,7,72 Data on maternal use of
omeprazole (and other PPIs) during breastfeeding are very limted.217 Some experts suggest that since
these medications are excreted in low amounts into breast milk and are extremely acid labile and
therefore likely to be destroyed in the stomach before infant absorption could occur, they are not
expected to cause any adverse effects in breastfed infants.6,219,220
Analgesics Acetaminophen is the drug of choice.6,218 Like acetaminophen, ibuprofen is routinely used to treat
infant fevers. Ibuprofen is compatible with breastfeeding with low levels passing into breast milk.6 Other
options include ASA, codeine and naproxen. ASA is excreted into breast milk; however, no cases of
Reye's syndrome from breast milk exposure have been documented.6,185 Codeine, although compatible
in most cases, can produce serious toxicity in infants whose mothers are ultrarapid metabolizers of
CYP2D6.88,188,192 More data are available for ibuprofen than naproxen sodium. Ibuprofen has a slightly
shorter half-life than naproxen sodium—2 h vs. 10 h.185 See also: Pharmacologic Therapy in Postpartum
Perineal Care and Postepisiotomy Pain section.
Antidiarrheals Bulk-forming agents (e.g., psyllium) and attapulgite are not absorbed. Loperamide and bismuth have
minimal GI absorption, and are unlikely to affect a breastfed infant.6 Salicylate is absorbed from bismuth
subsalicylate; however, there are no documented reports of Reye's syndrome in infants exposed to
salicylates via breast milk.6
Drug Class Comments
Antihistamines See Table 9. First- and second-generation antihistamines can be used.6,72,80 First-generation
antihistamines may cause sedation and irritability in the infant and reduce milk production due to their
anticholinergic effects.
Decongestants See Table 9. Saline nasal spray is the drug of choice. No data available for medicated nasal sprays but
due to minimal systemic absorption are preferred over oral agents.218 Oral pseudoephedrine is
considered safe in breastfeeding; however, it may reduce milk production and cause irritability in the
infant.6,218
Laxatives Bulk-forming agents are preferred for preventing constipation as they are not absorbed.218 Glycerin
suppositories can be used for acute constipation. GI absorption is minimal for bisacodyl, docusate, PEG
and lactulose and they are unlikely to affect a breastfed infant.6,218 Senna and cascara have been
associated with loose stools or diarrhea in some breastfed infants.6,218 Avoid mineral oil and castor oil
due to the potential to reduce absorption of fat-soluble vitamins.
Vitamins and Appropriate when used in normal doses. In addition to folic acid supplementation before and during
minerals pregnancy, it is recommended that women continue daily supplementation with a multivitamin
containing folic acid 0.4–1 mg for 4–6 wk postpartum, or as long as breastfeeding continues.16 Calcium
supplementation may be needed to achieve the recommended intake (<19 y = 1300 mg/day, 19–50 y =
1000 mg/day) and replace maternal calcium stores which are transferred into breast milk. Vitamin D
intake should be 600 IU/day during breastfeeding.20,21,22 Iodine requirement is increased during
breastfeeding (i.e., 250–290 µg/day).26,29 Supplementation with 150 µg/day is recommended.25,29
a See Table 1 for general principles of drug therapy during breastfeeding.
Abbreviations: ASA = acetylsalicylic acid, aspirin; H2 = histamine 2; IU = international units; PEG = polyethylene glycol; PPI = proton pump inhibitor
.....
Suppression of Lactation
Introduction
For women who are unable to breastfeed or choose not to, suppression of lactation may be desired. Without suckling stimulation,
lactation will gradually cease. However, women may experience leakage, engorgement and/or pain before lactation ends.221 These
symptoms begin 1–4 days postpartum and peak by day 3–5, with some women still experiencing pain at day 14.222
Despite lack of evidence, the following nonpharmacologic methods are routinely used to reduce the discomfort associated with
lactation suppression:
Wearing a well-fitting, supportive bra (recommended over breast binding which is associated with more breast leakage,
tenderness and pain)223
Expressing milk gently (by hand or pump) just enough to relieve pressure but not fully emptying the breast. A warm shower or
compress helps induce milk letdown to facilitate expression.221 Those who have experienced loss of a child may find comfort in
donating their expressed milk if a milk bank is readily available
Placing ice packs or cold cabbage leaves in the bra to reduce pain and swelling.221
Nonprescription analgesics are used to reduce pain.221 In 1988 the US FDA recommended against the routine use of pharmacologic
therapies (other than analgesics) for lactation suppression.222 Bromocriptine and estrogen are not recommended due to lack of
evidence of efficacy and safety concerns including risk of seizures, MI or severe hypotension with bromocriptine224,225 and venous
thromboembolism with estrogens postpartum.224
.....
Drug Tables
Table 8: Drug Therapy for Nausea and Vomiting of Pregnancya
Drug/Costb Dosage Adverse Monitoring of Therapy Comments

Effects
Drug Class: Antihistamine Antiemetics
dimenhydrinate 50–100 mg Q4–6H Sedation, Monitor patient for signs and Can also be given
Gravol PRN po or pr anticholinergic symptoms of sedation and parenterally. Minimal
Preparations, (maximum 200 effects, e.g., anticholinergic effects, e.g., dry data on efficacy.
generics mg/day when used dry mouth, mouth, constipation. Reassess if
concurrently with constipation.46 nausea and vomiting not improved
$ Diclectin 4 No known after 3 days or adverse effects are
tablets/day)37,45 teratogenic intolerable.
effects.47
Drug Class: Antihistamine/vitamin combination
doxylamine 1 tablet in the Sedation, Monitor patient for sedation and Considered drug of
delayed- morning and anticholinergic anticholinergic effects. Reassess if choice.
release/pyridoxine afternoon and 2 effects e.g., nausea and vomiting not improved Use on a regular rather
10 mg/10 mg tablets at dry mouth, after 3 days or adverse effects than PRN basis.
Diclectin bedtime41 constipation.48 intolerable. Up to 12 tablets/day
can be used in some
$$$ cases.
Taper on
discontinuation.48
ginger 250 mg QID or 500 Belching52 Reassess if nausea and vomiting Onset of action is up
Gravol Ginger, mg BID po not improved in 5 days. to 3 days.
others (maximum 1000 Dose based on
mg/day)41,49,50,51 powdered ginger root.
$ Products may not be
standardized.
Drug Class: Vitamins
pyridoxine 10 mg or 25 mg No known Refer to physician if nausea and Has reduced nausea

generics Q8H po teratogenic vomiting not improved in 3 days. and vomiting in small
Preliminary data effects in RCTs.56,57 Consider
$ suggest doses up doses used for other sources of
to 200 mg/day can nausea and pyridoxine in total
be safely used in vomiting.54 dose (e.g., Diclectin,
pregnancy53 High doses prenatal vitamin).
(especially
>1000
mg/day) have
been
associated
with
neuropathy.55
a To be used only on the advice of a healthcare practitioner.

b Cost of 1–day supply; includes drug cost only.

Legend: $ <$2 $$ $2–4 $$$ $4–6
Table 9: Selected Drug Therapy for Allergic Rhinitis and the Common Cold in Pregnancy and Breastfeeding
Drugab/Costc Dosage Maternal Monitoring of Therapy Comments

Adverse Effects
Drug Class: Antihistamines, first-generation

Adverse Effects
brompheniramine 4 mg Q4–6H Sedation (less Monitor mother for sedation Pregnancy:

No single-entity po (maximum than with and anticholinergic effects, e.g., Limited data. Initial data
products. 24 mg/day) diphenhydramine), dry mouth.71 suggested a possible
Component of anticholinergic congenital defect
many cough/cold effects, including Monitor breastfeeding infant for association but this was
products: , mucosal drying, signs of irritability, excessive not seen in subsequent
Robitussin, which may inhibit crying and altered sleep.6,72 studies.73,74
generics lactation.71 If infant experiences these If possible, avoid in last 2
effects or if mother's symptoms wk of pregnancy due to
$ do not improve after 1 wk, possible neonate
reassess. withdrawal and increased
risk of retinopathy of
prematurity.1,66,73,75
Breastfeeding:
Limited data. Irritability,
excessive crying and
disturbed sleeping have
been reported in a
breastfed infant.6,72,73
Small, occasional doses
unlikely to cause adverse
effects.72
chlorpheniramine 4 mg Q4–6H Sedation (less Monitor mother for sedation Pregnancy:

Chlor-Tripolon, po (maximum than with and anticholinergic effects, e.g., Considered safe in
generics 24 mg/day) diphenhydramine), dry mouth.71 pregnancy/drug of
anticholinergic
$ effects, including Monitor breastfeeding infant for choice.3,76
mucosal drying, signs of irritability, excessive Most data support no
which may inhibit crying and altered sleep.6,72 increased risk of
congenital effects. If
lactation.71 If infant experiences these possible, avoid in last 2
do not improve after 1 wk, possible neonatal
prematurity.12,66,75,77
Breastfeeding:
Very limited data.
Sedation or irritability
possible in the infant.6,72
Small occasional doses
unlikely to cause adverse
effects.72
Adverse Effects
diphenhydramine 25–50 mg Sedation, Monitor mother for sedation Pregnancy:

Benadryl Q4–6H po anticholinergic and anticholinergic effects, e.g., Most data support no
Preparations, (maximum effects, including dry mouth.71 increased risk of
generics 300 mg/day) mucosal drying, congenital effects in
which may inhibit Monitor breastfeeding infant for
signs of irritability, excessive pregnant women.
$ lactation.71 Considered compatible
crying and altered sleep.6,72
with pregnancy.3,78
If infant experiences these If possible, avoid in last 2
do not improve after 1 wk, possible neonatal
prematurity. Avoid use
with temazepam as
animal data suggest an
increased risk of
stillbirth.12,75,78
Breastfeeding:
Very limited data.
Excreted into breast milk.
Sedation or irritability
possible in the
infant.6,72,78
Drug Class: Antihistamines, second- generatione
cetirizine 5–10 mg once Preferred by Monitor mother for sedation Pregnancy:

Reactine, daily po patients due to and anticholinergic effects, e.g., Considered safe in
generics ease of dry mouth.71 pregnancy, although more
administration safety data are available
and because it is Monitor breastfeeding infant for
$ for first-generation
nonsedating in signs of irritability, excessive
crying and altered sleep.6,72 antihistamines.3,70,76,79,80
most patients.69 Breastfeeding:
Sedation and If infant experiences these
anticholinergic effects or if mother's symptoms Likely excreted in human
effects, including do not improve after 1 wk, breast milk in small
mucosal drying, reassess. amounts.
which may inhibit BSACI considers drug of
lactation but less choice for urticaria;
common than however, very limited
with first- specific data available and
generation no data for hydroxyzine
(the parent
antihistamines.71
compound).6,72,79,81
Approved in children >2 y.
Theoretically less likely to
cause sedation or
irritability in an infant than
first-generation
antihistamines.
Adverse Effects
desloratadine 5 mg once Preferred by Monitor mother for sedation Pregnancy:

Aerius, generics daily po patients due to and anticholinergic effects, e.g., Animal data and human
ease of dry mouth.71 data for the parent
$ administration compound (loratadine)
signs of irritability, excessive suggest it is safe, but no
nonsedating.69 human data are available
Sedation and crying and altered sleep.6,72
with desloratadine.76,82
anticholinergic If infant experiences these Breastfeeding:
effects, including effects or if mother's symptoms
mucosal drying, do not improve after 1 wk, No specific data available,
which may inhibit reassess. but loratadine levels in
lactation but less breast milk are very small
common than and AAP classifies the
with first- parent compound
generation (loratadine) compatible
antihistamines.71 with breastfeeding.6,72,82
cause sedation or
first-generation
antihistamines.
fexofenadine 120 mg daily Preferred by Monitor mother for sedation Pregnancy:

Allegra po (given as patients due to and anticholinergic effects, e.g., Animal data suggest
60 mg BID or ease of dry mouth.71 possible concerns. Very
$ as 120 mg administration limited human data
once daily) and because it is Monitor breastfeeding infant for
signs of irritability, excessive available.76,83,84
nonsedating.69 Considered an alternative
Sedation and crying and altered sleep.6,72
agent to those with better
anticholinergic If infant experiences these and/or more safety data.
effects, including effects or if mother's symptoms Breastfeeding:
mucosal drying, do not improve after 1 wk,
which may inhibit reassess. Likely excreted into breast
lactation but less milk in small amounts.
common than AAP classifies it as
with first- compatible with
generation breastfeeding. However,
no specific data are
antihistamines.71
available. Limited data
available for the parent
compound
(terfenadine).6,72,83
cause sedation or
first-generation
antihistamines.
Adverse Effects
loratadine 10 mg once Preferred by Monitor mother for sedation Pregnancy:

Claritin, Claritin daily po patients due to and anticholinergic effects, e.g., Considered safe in
Liquid Capsules, ease of dry mouth.71 pregnancy, although more
generics administration safety data are available
signs of irritability, excessive for first-generation
$ nonsedating.69
crying and altered sleep.6,72 antihistamines.3,70,76,80,85
Sedation and Breastfeeding:
anticholinergic If infant experiences these
effects, including effects or if mother's symptoms Small amounts excreted
mucosal drying, do not improve after 1 wk, in human breast milk.6,72
which may inhibit reassess. Approved in children >2
lactation but less y.86
common than AAP and BSACI classifies
with first- it as compatible with
generation
breastfeeding.81,85
antihistamines.71 Theoretically less likely to
cause sedation or
first-generation
antihistamines.
Drug Class: Antitussives
codeine 10–20 mg Sedation, Use under healthcare Pregnancy:

generics Q4–6H PRN constipation, practitioner supervision. Should Data do not suggest risk
po (maximum palpitations, and not exceed 4 days in a
breastfeeding mother. Closely of birth defects.88,91
$ 120 mg/day)87 dizziness.88
monitor breastfeeding infants If possible, avoid use in
for sedation, lethargy, grey skin the first trimester.
and poor milk intake: refer to Avoid long-term use or
appropriate healthcare high doses close to term
practitioner if these symptoms (risk of neonatal opiate
develop.6,72,89,90 In most cases, withdrawal).88
there is consistency between Breastfeeding:
CNS depression in mother and Indicated for
infant. If the mother is nonproductive cough.87
symptomatic (e.g., somnolent, Mothers who are
groggy), the infant should be ultrarapid metabolizers of
examined for signs of CNS CYP2D6 have increased
depression.89 conversion of codeine to
morphine which resulted
in death of a breastfed
infant. Although a minority
of the population are rapid
metabolizers of 2D6,
caution is warranted; use
the lowest effective dose
for 4 days or less, or use
alternative treatment
options.6,72,89,90
Adverse Effects
dextromethorphan 10–20 mg Minimal Monitor infant for sedation.6 Choose ethanol-free

Q4H or 30 mg If symptoms do not improve products.
Benylin DM, Q6–8H po after 1 wk, reassess. Pregnancy:
Robitussin DM, (maximum Considered safe in
generics 120 mg/ pregnancy.
day)92 Most data support no
$ increased risk of
congenital effects.12,75,93
Breastfeeding:
Indicated for
nonproductive cough.92
No data in human
breastfeeding, but
considered probably
safe.6,72,93
Drug Class: Corticosteroids, intranasal
mometasone 2 sprays in Nasal irritation, Monitor mother for nasal Pregnancy:

furoate each nostril sore throat.94 irritation, sore throat and Avoid use in first trimester
Nasonex once daily reduced milk supply.
Monitor breastfeeding infant for if possible.96
Reduce to 1 No human data.
$$$ reduction in feeding, growth,
spray in each Considered probably
nostril once weight gain.72,95 compatible with
daily if pregnancy based on low
possible systemic bioavailability
and safety of other
inhaled corticosteroids in
asthma.97
Breastfeeding:
No human data.
Considered probably
compatible based on
minimal maternal
systemic absorption via
intranasal route.72,95,97
triamcinolone 2 sprays in Nasal irritation, Monitor mother for nasal Pregnancy:

acetonide each nostril sore throat.94 irritation, sore throat and Avoid use in first trimester
Nasacort Allergy once daily reduced milk supply.
24HR Monitor breastfeeding infant for if possible.96
Reduce to 1 Considered compatible
spray in each reduction in feeding, growth,
$$ with pregnancy based on
nostril once weight gain.72,98 data with inhaled form
daily if and safety of other
possible inhaled corticosteroids in
asthma.99
Breastfeeding:
Considered compatible
based on minimal
maternal systemic
absorption via intranasal
route.72,99
Drug Class: Decongestants, oral

Adverse Effects
phenylephrine 10 mg Q4H po Signs and If mother's adverse effects Pregnancy:

No single entity (maximum 60 symptoms of intolerable or symptoms do not Limited evidence of
products. mg/day) adrenergic improve after 1 wk, ressess. possible association with
Component of Efficacy at stimulation; Monitor infants for signs and endocardial cushion
many cough/cold currently palpitations, symptoms of adrenergic defect with first trimester
products:, recommended increased blood stimulation, e.g., irritability, use, however absolute risk
Robitussin, others oral dosages pressure, excessive crying, altered sleep
has been nervousness, minimal.101,102 Potentially
patterns.6 can reduce uterine blood
$ questioned100 insomnia and
dizziness.100 flow.70,75,103
May reduce milk If possible, avoid use,
production. particularly in the first
trimester.70,102
Breastfeeding:
Although oral
bioavailability is low, it
may be excreted into
breast milk in small
amounts. No data in
human breastfeeding are
available. May reduce milk
production.6,72
Not preferred as
alternatives with better
and/or more safety data
exist.
pseudoephedrine 30–60 mg Signs and If mother's adverse effects Pregnancy:

Q4–6H po symptoms of intolerable or symptoms do not Generally considered safe
Eltor 120, (maximum adrenergic improve after 1 wk, reassess. in pregnancy. Some
Sudafed, generics 240 mg/day) stimulation; Monitor infants for signs and sources recommend
palpitations, symptoms of adrenergic avoidance of
$ increased blood stimulation, e.g., irritability, pseudoephedrine during
pressure, excessive crying, altered sleep the first trimester based
nervousness, patterns.6,72,104,105 on a single, small study
insomnia and showing increased risk of
dizziness.100 gastroschisis,106 however,
May reduce milk a subsequent, larger study
production. from the same group did
not show increased
risk.102
Breastfeeding:
Excreted in breast milk in
small amounts but AAP
classifies it as compatible
with breastfeeding.
Irritability has been
reported in breastfed
infants. Avoid in mothers
with insufficient milk
production.6,72,105
Drug Class: Decongestants, topical

Adverse Effects
oxymetazoline Use lowest Local burning and If symptoms not improved after Pregnancy:
Claritin Allergy effective dose stinging, sneezing 3–5 days refer to physician.12 Generally considered safe
Decongestant, according to and dryness of Monitor infants for signs and
Dristan Long manufacturer's nasal mucosa. in pregnancy;75,80
symptoms of adrenergic however, data on safety
Lasting Nasal instructions Use sparingly stimulation, e.g., irritability,
Mist, generics (maximum 3–5 are limited and
excessive crying, altered sleep
days) to minimize conflicting.102,107 No
$ patterns.6 adverse effects reported
tolerance or
rebound with single dose use.108
congestion.12 Using higher than the
recommended dose may
reduce uterine blood
flow.109
Breastfeeding:
No data in human
breastfeeding. Preferred
over oral agents due to
presumed low systemic
absorption.4,6,72
sodium chloride Spray into Well tolerated. If symptoms not improved after Pregnancy:
(normal saline) nostrils as 1 wk, reassess. Drug of choice. Safety
Hydrasense, needed
Rhinaris, Salinex, well established.66,69
generics Breastfeeding:
Drug of choice. Safety
$ well established.
xylometazoline Use lowest Local burning and If symptoms not improved after Pregnancy:
Balminil, Otrivin, effective dose stinging, sneezing 3–5 days refer to physician.12 Generally considered safe
generics according to and dryness of Monitor infants for signs and
manufacturer's nasal mucosa. in pregnancy;75,80
symptoms of adrenergic however, data on safety
$ instructions Use sparingly stimulation, e.g., irritability,
(maximum 3–5 are limited and
excessive crying, altered sleep
days) to minimize conflicting.102,107 No
patterns.6 adverse effects reported
tolerance or
rebound with single dose use.108
congestion.12 Using higher than the
recommended dose may
reduce uterine blood
flow.109
Breastfeeding:
No data in human
breastfeeding. Preferred
over oral agents due to
presumed low systemic
absorption.4,6,72
Drug Class: Mast cell stabilizers
sodium 1 spray in each Nasal irritation, Monitor breastfeeding infant for Pregnancy:
cromoglycate nostril 6 times sneezing, cough, irriatbility, insomnia, diarrhea, Considered compatible
Rhinaris CS Anti- daily unpleasant constipation and weight gain.6
allergic with pregnancy.111
Reduce to taste.110 Breastfeeding:
BID–TID after
$$ No data.
adequate
Considered compatible
response110 due to low systemic
absorption.6,72,111
a Consider the risk vs. benefit for each individual, including any risk associated with undertreating a maternal condition.
b Use the lowest effective dose for the shortest duration possible. Short-acting formulations are generally preferred to minimize fetal/infant
exposure time. Avoid alcohol/ethanol-containing liquid formulations.
c Cost of smallest available pack size; includes drug cost only.
d May reduce rhinorrhea, sneezing, nasal itch and congestion via antihistamine and anticholinergic effects.
e May reduce rhinorrhea, sneezing, nasal itch and congestion via antihistamine effects.
f Relief of cough through centrally mediated cough suppression. A combination of a first-generation antihistamine and a decongestant is
recommended for coughs due to postnasal drip, i.e., upper airway cough syndrome.
g Other corticosteroid nasal products are available on prescription. For more information see Allergic Rhinitis.
h Relief of congestion through vasoconstriction of respiratory mucosa.
i Relief of congestion through vasoconstriction of respiratory mucosa or osmotic effect (normal saline).
Abbreviations: AAP = American Academy of Pediatrics; BSACI = British Society for Allergy and Clinical Immunology; CNS = central nervous
system; CYP = cytochrome P450; NVP = nausea and vomiting of pregnancy
Legend: $ <$10 $$ $10–20 $$$ $20–30

Table 10: Selected Drug Therapy for Perineal Care and Postepisiotomy Paina
Drug/Costb Dosage Adverse Drug Interactions Comments

Effects
Drug Class: Analgesics
acetaminophen 325–650 mg Q4– Minimal. Acetaminophen has been reported to If pain not relieved
Atasol 6H PRN po increase INR in warfarin-treated after 2 days, further
Preparations, (maximum 4000 patients.183 Check INR if assessment required.
Tylenol, mg/day)182 acetaminophen ≥2 g/day is used for Considered safe in
generics ≥3 consecutive days. Adjust warfarin breastfeeding mothers.
dosage as required. Amount in breast milk
$ significantly less than
pediatric therapeutic
dose.6
ibuprofen 200–400 mg Q6– GI effects Warfarin: Increased anticoagulant If pain not relieved
Advil, Advil 8H PRN po (e.g., nausea, effect. Antihypertensives: possible after 2 days, further
Liqui-Gels, (maximum dose heartburn), reduction in antihypertensive effect assessment required.
Motrin, Motrin for self–care: dizziness.184 which may require additional Considered safe in
IB, Motrin 1200 mg/day)184 antihypertensive therapy. breastfeeding mothers.
Liquid Gels, Lithium may interfere with Amount in breast milk
generics sodium/water balance. Monitor significantly less than
lithium levels when NSAID added. pediatric therapeutic
$ Increased risk of GI bleeding with dose.6
SSRIs.
naproxen 220–440 mg/day GI effects Warfarin: Increased anticoagulant If pain not relieved
sodium PRN po in 1 or (e.g., nausea, effect. Antihypertensives: possible after 2 days, further
Aleve, generics divided doses heartburn), reduction in antihypertensive effect assessment required.
(maximum dose dizziness.184 which may require additional Considered safe in
$ for self–care: 440 antihypertensive therapy. breastfeeding.
mg/day) Lithium may interfere with However, more data
sodium/water balance. Monitor available for ibuprofen,
lithium levels when NSAID added. and ibuprofen has a
Increased risk of GI bleeding with shorter half-life.6,185
SSRIs.
Drug Class: Local agents
hamamelis Use as needed for Contact May reduce itching and

Tucks comfort dermatitis.186 pain.
Medicated If pain not relieved
Pads after 2 days,
recommend a trial of
$$$/40 pads oral analgesic.
a See Table 1 for general principles of drug therapy during breastfeeding.

b Cost of 1-day supply unless otherwise specified; includes drug cost only.
Legend: $ <$2 $$ $2–4 $$$ $4–6
Resource Tips
LactMed (a database, from the U.S. National Library of Medicine, of drugs and other chemicals to which breastfeeding mothers may
be exposed. Includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in
the nursing infant). Available from: toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT.
Lalonde A, Schuurmans N, Senikas V. Healthy beginnings: giving your baby the best start, from preconception to birth. Available from:
www.sogc.org/healthybeginnings/index.html.
Motherisk (a Canadian clinical, research and teaching program dedicated to antenatal drug, chemical and disease risk counselling).
Motherisk Helpline: 416-813-6780. Available from: www.motherisk.org.
Motherisk. Alcohol and Substance Use Helpline: 1-877-327-4636. Available from: www.motherisk.org/prof/alcohol.jsp.
Motherisk. Nausea and Vomiting of Pregnancy (NVP) Helpline: 1-800-436-8477. Available from:
www.motherisk.org/prof/morningSickness.jsp.
Organization of Teratology Information Specialists. MotherToBaby. Fact Sheets. Available from: www.mothertobaby.org/otis-fact-
sheets-s13037.
Public Health Agency of Canada. The healthy pregnancy guide. Available from: www.phac-aspc.gc.ca/hp-gs/guide/index-eng.php.
Society of Obstetricians and Gynaecologists of Canada. Available from: www.sogc.org.
Suggested Readings
Briggs GG, Freeman RK. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. 10th ed. Philadelphia: Wolters
Kluwer; 2014.
Exposure to psychotropic medications and other substances during pregnancy and lactation: a handbook for health care providers (a
Canadian resource developed by the Centre for Addiction and Mental Health and the Motherisk Program). Available from:
www.camh.ca/en/education/about/camh_publications/Pages/exposure_psychotropic_meds_pregnancy.aspx.
Ferreira E, Martin B, Morin C. Grossesse et allaitement: guide thérapeutique. 2nd ed. Montréal: CHU Sainte-Justine; 2013.
Hale TW, Rowe HE. Medications and mothers' milk: a manual of lactational pharmacology. 16th ed. Plano: Hale Publishing; 2014.
Society of Obstetricians and Gynaecologists of Canada. Clinical practice guidelines [multiple topics]. Available from: sogc.org/clinical-
practice-guidelines/.
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Urinary Incontinence
Cheryl A. Sadowski, BSc(Pharm), PharmD

Introduction
Urinary incontinence has traditionally been defined as the involuntary loss of urine.1 However, the term lower
urinary tract symptoms (LUTS) is used to describe the broader spectrum of symptoms that can occur with
or without incontinence, which can increase morbidity in many individuals.1,2,3
LUTS can be broadly classified into storage or voiding symptoms and can be acute or chronic.4,5 Storage
symptoms include daytime frequency, nocturia and urgency. These are often attributable to an overactive
bladder, the primary focus of this chapter. Voiding symptoms are associated with benign prostatic
hyperplasia, urinary obstruction, poorly contractile bladder or sphincter dysfunction, leading to urinary
hesitancy, slow stream, incomplete bladder emptying and dribbling (see Benign Prostatic Hyperplasia and
Associated Lower Urinary Tract Symptoms).
The main types of urinary incontinence include: urge, stress, mixed (urge and stress), overflow, and
functional (inability to toilet) incontinence.4,6,7 Worldwide, LUTS are very common (14% of men and >30% of
women) and will become more so as the population ages.8 In the Canadian Urinary Bladder Survey (CUBS),
43% of men and 57% of women report one or more LUTS.9 The mean age of men was only 44 years and of
women 45 years.
In addition to the over $1 billion/year spent on the treatment of LUTS in Canada, the economic impact (e.g.,
work disruptions) and psychosocial issues (e.g., stigma, embarrassment, isolation, anxiety and depression)
can be very costly.8,10,11,12,13,14,15 LUTS are associated with medical complications (e.g., skin breakdown,
pressure ulcers, increased frequency of urinary tract infections, increased rate of falls and fractures).16,17,18
It appears that urinary urgency has the greatest impact on quality of life, although all forms of LUTS have
also been associated with decreased quality of life, affecting recreational activities, sexual activities and
daily life.11,19,20
Pathophysiology
The lower urinary tract includes the bladder and urethra and has 2 functional phases—storage and voiding.
During the storage phase, the detrusor muscle relaxes and the urethral sphincter tightens. The voiding
phase, also known as the micturition cycle, starts when the mechanoreceptors in the bladder wall are
stimulated as the bladder volume approaches 250 mL (this volume varies by individual, from 150–600 mL).
The cortical centre is then alerted and if the individual is in an appropriate setting, the detrusor muscle
contracts while the sphincter opens in a coordinated fashion to allow urine to flow.
The bladder is innervated by the autonomic nervous system (Figure 1). The sympathetic system causes
relaxation of the detrusor muscle and tightening of the sphincter. Conversely, the parasympathetic system
causes contraction of the detrusor and relaxation of the sphincter. In a “fight or flight” response, when the
sympathetic system is dominant, the body shuts down the urinary tract to divert blood and attention to other
urgent issues.
Figure 1: Innervation of Bladder Structures

A: Detrusor muscle contraction due to parasympathetic activity B: Detrusor muscle relaxation due to inhibition of parasympathetic
activity C: Bladder relaxation due to beta-adrenergic sympathetic activity D: Bladder neck/sphincter contraction due to alpha-
adrenergic sympathetic activity E: Pelvic floor muscle contraction due to voluntary somatic activity
While LUTS are not necessarily a normal part of aging, older adults are more susceptible to these symptoms
due to changes in physiology such as decreased bladder capacity, increased post-void residual volume and
increased spontaneous bladder muscle contractions.21,22 The pathophysiology depends on the type of
incontinence (Table 1). Some medications are associated with causing or exacerbating urinary incontinence
(Table 2).23,24,25
Table 1: Types of Urinary Incontinence

Type of
Incontinence Pathophysiology Symptoms Contributing Factors
Stress Loss of bladder neck Urine loss triggered by Pregnancy, childbirth,
incontinence support (weak pelvic activities that cause a pelvic organ prolapse,
floor muscle) and/or rise in intra-abdominal postmenopausal
intrinsic urethral pressure such as atrophic changes, pelvic
sphincter deficiency; coughing, sneezing, surgery (e.g., prostate
more common in jumping, lifting, surgery), obesity,
women. exercise, shouting. smoking, medications
Variable volumes of (see Table 2).
urine lost.
Type of
Incontinence Pathophysiology Symptoms Contributing Factors
Urge Involuntary contractions Involuntary loss of urine Age; dementia; obesity;

incontinence due to instability of due to inability to postmenopausal
(“overactive detrusor muscle (or postpone voiding when atrophic changes;
bladder”) hyper-reflexia of the urge is first prostate surgery;
detrusor muscle due to perceived. neurologic damage
neurologic disorder). Symptoms include associated with
Results in inability to frequency, nocturia conditions such as
suppress contractions; enuresis. diabetes, stroke,
more common in older multiple sclerosis,
individuals and those Can be triggered by Parkinson disease;
with neurologic cues such as running bladder irritants such as
conditions (e.g., multiple water or opening the infection, stones,
sclerosis, spinal cord door to the bathroom. concentrated urine from
injury). Variable volumes of inadequate fluid intake;
urine lost. constipation;
medications (see Table
2).
Mixed Features of both stress Symptoms of both Combination of stress

stress/urge and urge incontinence. stress and urge and urge incontinence
incontinence incontinence. factors.
Overflow Bladder outlet Continuous dribbling of Prostatic hyperplasia,

incontinence obstruction or detrusor small volumes of urine; bladder neck
hypoactivity. occurs predominantly in contracture, urethral
men with prostatic stricture, constipation,
hyperplasia. Urinary diabetes, neurologic
bladder is almost problems, medications
always full. (see Table 2).
Functional Genitourinary system is Patient has loss of Cognitive and/or

incontinence normal, but the patient urine; occurs physical impairment;
is physically unable to predominantly in psychological and/or
get to or use the toilet in patients with physical environmental barriers
time. disability, dementia or (e.g., lap belts or trays
other psychiatric illness. in a geri-chair, locked
areas of a facility, stairs
required to reach a
toilet).
Table 2: Drugs Associated with Urinary Incontinence

Urinary Symptom Medications Mechanism
Functional incontinence Alcohol Loss of central micturition

Antidepressants (if sedating) reflex; manifests as decreased
awareness of need to urinate.
Antipsychotics
Muscle relaxants
Opioids
Sedative-hypnotics
Urinary Symptom Medications Mechanism
Cholinergic agonists (e.g., Increased urinary frequency

bethanechol) associated with detrustor
Cholinesterase inhibitors (e.g., muscle contractions.
donepezil, galantamine,
rivastigmine)
Overflow incontinence Alpha-agonists (e.g., Urinary retention resulting from

decongestants, midodrine, impaired detrusor contractility or
pseudoephedrine) urethral sphincter tightening.
Anticholinergics Opioids also cause constipation,
Calcium channel blockers which increases
parasympathetic discharge.
Opioids
Stress incontinence ACE inhibitors Decreased urethral sphincter

Alpha-antagonists (e.g., tone.
tamsulosin, terazosin) ACE inhibitors may cause cough,
Cholinergic agonists (e.g., which increases intra-abdominal
bethanechol) pressure.
Cholinesterase inhibitors (e.g.,

donepezil, galantamine,
rivastigmine)
All types of urinary Diuretics (e.g., furosemide) Increased urinary output and
incontinence Glucocorticoids (systemic) detrusor contractions.
NSAIDs (e.g., celecoxib) Fluid retention leading to

nocturnal enuresis.
Thiazolidinediones
Goals of Therapy
Eliminate or reduce frequency of incontinence episodes
Eliminate or reduce severity of symptoms
Prevent complications:
urinary tract infections
skin breakdown
falls
catheterization
Improve quality of life for patient and caregivers
Patient Assessment
The key areas of patient assessment are bladder history, previous pelvic surgery, medical history (including
medication history), physical examination and laboratory investigations.3,26,27,28,29,30 A full assessment
requires medical workup with a physical examination, laboratory data and possibly urodynamic and
cystoscopic evaluations.31
Bladder History
A number of questionnaires and structured instruments have been designed to determine whether LUTS
are problematic for individuals. The basic 3 items are if, when, and how urinary symptoms occur.26 Some
experts have recommended starting the interview or approaching patients with the following case-
finding questions:32,33,34
Do you ever leak urine/water when you do not want to?

Do you ever leak urine/water when you cough, laugh or exercise?
Do you leak urine/water on the way to the bathroom?
Do you ever use pads, tissues, or cloth in your underwear to catch urine/water?
Do you use pads or protective garments?
How often do you leak urine?
Bladder or voiding diaries can also be helpful in documenting a patient's particular symptom pattern and
response to therapy. Table 3 presents a reliable and validated sample diary for patients to use. A 3-day
diary collection of data is recommended to assess the situation.3,35
Table 3: Sample Voiding Diary

What
activity
Did were
you you
Bathroom: feel a doing
Intake of
Urine Accidental strong when
Liquids
Volume Leaks urge you
Type Volume S = small S = small to go? had
Time M= M= Y= the
of moderate moderate yes urge to Pad/Absorbable
Date day L= large L= large N = no go? Product Use
Medical History
Gynecologic and obstetric history

History of pelvic surgery
Bowel history
Comorbid conditions, e.g., diabetes, stroke, arthritis, Parkinson disease
Sensory impairments, e.g., vision
Functional status and mobility
Current and recently used medications (see Table 2)
Physical Examination
A thorough physical exam is required to rule out modifiable contributing factors. Assessment should
include:
Abdominal examination (e.g., bladder distension)

Pelvic/gynecologic functions (e.g., cystocele, prolapse)
Rectal function (e.g., tone, fullness)
Prostate evaluation (e.g., size, consistency, symmetry, tenderness)
Neurologic function (e.g., sensory and motor)
Musculoskeletal function (e.g., mobility)
Investigations
Urinalysis
Urine culture
Bladder scan to assess postvoid residual volume
If further workup is required:36
Serum metabolic profile, e.g., electrolytes, glucose

Urodynamic (uroflowmetry, cystometry, pressure flow studies) and cystoscopic evaluations
Ailments—Incontinence Products: Devices.
Nonpharmacologic interventions are considered first-line therapies and should be continued when
pharmacologic treatments are employed. The advantage of these measures is that they are often easy to
use, do not cause side effects and are less expensive than pharmacologic agents. Table 4 discusses
nonpharmacologic interventions.37,38,39,40,41,42,43,44,45
The choice of a first- vs. second-line approach is patient specific. A patient may choose an intervention that
is easy to implement, more readily accessible, or one that allows for treatment without any devices prior to
purchasing any products.
For each type of LUTS, it is appropriate to present the patient with the options and then to aid the patient in
deciding on the best method of treatment. Often patients will fare better with a combination of multiple
nonpharmacologic treatments or a combination of nonpharmacologic and pharmacologic interventions.
Table 4: Nonpharmacologic Therapy for Urinary Incontinence

Type of
Urinary
Intervention Incontinence Description Benefits Drawbacks
Timed voiding Urge or mixed Start with No financial Patient still is
voiding every 30 cost toileting
min, then Does not frequently at
eventually require a lot of the beginning
increase the training Life schedule
interval between can centre
voiding by 30 around toileting
min until the
individual can Takes many
control the weeks or
bladder for up to months to
3-h intervals. achieve control
Bowel management Urge or Relieving Decreased Requires

overflow constipation constipation treatment by
decreases diet or with
parasympathetic laxative
activity medications.
(decreased Caution with
involuntary additional fluid
bladder intake that can
contraction) or aid
can reduce constipation
pressure on the but worsen
bladder caused incontinence
by stool
impaction.
Electrical stimulation Urge, stress Brief electrical Device can be Invasive

(e.g., posterior tibial or mixed impulses are used May be
nerve, sacral, administered via independently expensive if
intravaginal) needles or by the patient therapy is not
surface covered by
electrodes to health plan
inhibit detrusor
overactivity, or Requires
to strengthen cleaning
the pelvic floor. Benefit is lost
The probe may after treatment
be inserted into cessation
the anus or
vagina.
Biofeedback Urge, stress A vaginal or Can be used Costly

exercises or mixed rectal probe independently Delay from time
detects at home of use to full
contractions benefit is
and sends an realized
auditory or
visual signal
telling the
patient how
strong the
contractions
are.
Pelvic floor muscle Urge, stress The individual Little cost and Can be
training (Kegel or mixed contracts the time required distracting if
exercises) pelvic floor, as if Can be done client attempts
to hold in flatus even if to complete
or interrupt mobility is a this while doing
urinary flow, for concern other activities
5 seconds, then Like any activity
relaxes for 10 involving
seconds. skeletal
Exercises are muscles, this
increased takes up to 6
starting at 30 wk to show
times per day. benefit. Can
The goal is to cause myalgia
hold the if exercises are
tensions for 10 overdone or
seconds, then done
relax for 20 improperly
seconds,
repeating up to
100 times per
day. Can also be
combined with
biofeedback.
Vaginal weights, Stress Tampon-shaped Discreet Weights must

vaginal cones weights are Does not be purchased
inserted into and require If weight is too
held in the counting and heavy it can fall
vagina for short timing like out
periods of time. Kegel
Gradually the May be
exercises distracting or
time is extended
and the weight uncomfortable
is increased. if not properly
inserted
Requires
cleaning
Like any activity
involving
skeletal
muscles, this
takes up to 6
wk to show
benefit
Physiotherapy (pelvic Urge, stress A Exercises can Like any activity

floor exercises) or mixed physiotherapist often be done involving
may work with independently skeletal
the patient to by the patient muscles, this
continue takes up to 6
exercises wk to show
beyond Kegel benefit
exercises to
improve pelvic
floor strength.
Surgical procedures Stress Repositioning of Most surgeries Most types of
for women: the bladder neck are minimally surgery have
Suburethral sling and urethra to invasive effects that last
(e.g., tension- the normal for many years
free vaginal tape, anatomic Women who
transobturator positions. plan to have
tape, synthetic more children
mesh tape) are not eligible
Open retropubic for surgery in
colposuspension most cases, as
the pregnancy
Bladder neck would negate
needle the surgical
suspension intervention
Laparoscopic
colposuspension
Surgical procedures Stress Usually used in Minimally Balloon may

for men: inflatable men after invasive become
implant prostatectomy, Immediate damaged and
implant is results require
inflated near the replacement
bladder neck to
lift it into correct
anatomical
position.
Pessary Stress A product is Can be Can cause

inserted into the inserted and erosions or
vagina and fitted left for vaginal
by a specialist extended infections if not
so that the periods of fitted or
pessary time cleaned
supports the Patient does properly
bladder and not feel the Can interfere
urethra through device if with sexual
the vaginal wall, inserted intercourse
while preventing properly
prolapse of the
vagina or cervix.
Bulking agents Stress A bulking agent Minimally Product may

(e.g., autologous invasive disperse and
fat, ethylene Results are procedure may
vinyl chloride, immediate have to be
collagen, or repeated
silicone) is Long term
injected around effects of
the bladder neck injections are
to provide better unknown
support and
positioning of
the bladder and
urethra.
Weight management Stress Weight loss in Other risk Lifestyle
if BMI >25 kg/m2 overweight factors interventions
individuals can improve, e.g., may be difficult
reduce pressure reduced risk of to implement
on the lower diabetes,
abdomen. improved
blood pressure
control
Catheterization Overflow A Foley catheter The patient Catheters

(indwelling can control increase the
catheter), or in- voiding if risk of urinary
and-out he/she and bladder
catheterization independently infections
can be done to conducts in- Mobility
bypass an and-out
obstruction. catheterization Embarrassment
due to urine
Accurate bag (for
measures of indwelling
urine volume, catheter)
content, etc.,
can be taken Some urine
leakage may
still occur
around the
catheter
Restriction of irritants Urge Caffeine and Benefit can be Lifestyle

(e.g., reduction in alcohol are noticed changes are
alcohol and caffeine diuretics and immediately often the most
intake) direct bladder difficult to
irritants. implement
Fluid intake Urge Ensuring Ensures urine Individuals

management consumption of that is not have difficulty
6–8 glasses of concentrated implementing
water/day to and irritating fluid intake
prevent when they deal
dehydration and with LUTS
concentrated Other
urine, which is a conditions,
bladder irritant; such as heart
avoiding fluids failure, may
in the evening. contraindicate
Some a certain
individuals may volume of fluid
require intake
restriction of
fluids to prevent
excessive urine
production.
Urethral plugs, Stress, The product Can be applied May cause
urethral caps, penile overflow blocks the by the patient irritation and
clamps urethra to skin erosion
prevent May increase
dribbling. urinary tract
infections
Commodes or urinals All The device is Easy access, Odour

placed at the usually at the Embarrassment
bedside or bedside
convenient to Some
Allows for individuals still
the individual to independence
allow for voiding require
in voiding if assistance to
when moving to mobility is a
a toilet is not an transfer onto
concern the commode
option.
or to use the
urinal
Environmental All Installing a Improved Some

modification higher toilet or safety in the interventions
toilet seat, environment can be costly
adding grab Decreased risk Can be
bars, or clearing of falls noticeable
the way for easy which can be
access to the associated with
toilet. social stigma
Adaptive clothing All Wear easy to Improved Can be costly

remove clothing. mobility and to purchase
Choose clothing comfort different
that can be clothes
easily cleaned May require a
and can change in style
accommodate of clothing
insertion of
pads or
absorbable
products.
Alarms All An alarm can be Can allow Expensive

used to alert patient to Invasive
someone for manage
scheduled toileting Alarm can let
toileting, or can independently others know
be used in the there is a health
underwear or problem
bedpad to
detect wetness.
Absorptive products All The product is Allow the Costly
(pads, guards, liners, worn to absorb patient to Numerous
undergarments, urine leakage. function types requiring
underwear, etc.) independently healthcare
Large practitioner to
selection of direct to the
products appropriate
available for product
different Odour if not
needs used properly
Urge Incontinence
For further discussion of pharmacologic therapy for urge incontinence, consult the Compendium of
Therapeutic Choices: Urinary Incontinence in Adults.
Some patients may self-treat with anticholinergic medications, such as dicyclomine, dimenhydrinate,
diphenhydramine or scopolamine. However, these medications are not recommended for the
management of urge incontinence due to the availability of safer and more effective alternatives.
The most common medications used for the treatment of urge incontinence have antimuscarinic
properties to reduce the responsiveness of the detrusor muscle to parasympathetic impulses. Such
agents include darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine and trospium. These drugs
reduce incontinence episodes, improve continence and often improve quality of life.46,47,48,49,50
However, some patients may not tolerate the increased incidence of side effects (e.g., constipation,
blurred vision, dry mouth) when using relatively less selective products (oxybutynin, tolterodine,
trospium).51,52,53,54,55,56,57 Due to toxicity and lack of approved indication for LUTS, tricyclic
antidepressants should not be used.
Botulinum toxin (onabotulinumtoxinA) injection into the detrusor muscle is approved for the
management of urinary incontinence.58,59 For troublesome nocturia in younger patients (<65 years of
age), desmopressin at bedtime may be of benefit but may increase the risk of hyponatremia.60,61 The
evidence is controversial regarding estrogen, but it appears that intravaginal estrogen may reduce
urinary urgency in some postmenopausal women with vaginal atrophy or dysuria and urge
incontinence.62,63
Stress Incontinence
This type of urinary incontinence is not usually treated pharmacologically. First-line treatment focuses on
pelvic floor muscle training (see Table 4).
Estrogen therapy is ineffective and should not be used to manage this type of urinary incontinence.46,64
Although duloxetine reduces the frequency of urinary incontinence episodes and improves quality of life
compared with placebo, it is associated with increased adverse effects (e.g., nausea, diarrhea, headache,
dizziness, fatigue, dry mouth, liver toxicity, suicidal ideation).62 Duloxetine is not licensed in Canada for
the management of stress urinary incontinence.
Mixed Stress/Urge Incontinence
When a patient exhibits symptoms suggestive of both urge and stress incontinence, treatment could be
directed at the predominant type or both types.
Overflow Incontinence
For further discussion of pharmacologic therapy for overflow incontinence, consult the Compendium of
Therapeutic Choices: Urinary Incontinence in Adults.
Bethanechol is a cholinergic agonist that increases parasympathetic activity, increasing bladder

contractions and relaxing sphincters. This medication can be used for bladder stimulation when it has
been confirmed that an obstruction is not present. The side effects are consistent with cholinergic
agonism and include diarrhea, nausea, hypersalivation and lacrimation. Alpha-blockers (nonselective:
doxazosin, prazosin, terazosin; selective: alfuzosin, tamsulosin) may be helpful in treating overflow
incontinence in cases of benign prostatic hyperplasia or sphincter hyperspasticity.
Monitoring involves the following general parameters and recording how bothersome they are:
Improvement in symptoms, e.g., nocturia, dysuria, hesitancy, urgency

Number of episodes of incontinence or severity of LUTS/day
Number of micturitions/day
Volume of urine/micturition
Number of absorptive products used
Urinary flow parameters
When starting pharmacologic therapy, the healthcare practitioner should monitor the patient on a weekly
basis for the first month then monthly for the next 3 months then once or twice yearly. This ensures that side
effects due to medication use are addressed promptly and informs the healthcare practitioner if the
medication is beneficial in reducing symptoms of urinary incontinence. Voiding diaries are useful patient
tools for monitoring the efficacy of interventions (see Table 3) and the patient should be encouraged to
monitor symptoms daily until symptom control in achieved.
Resource Tips
Bladder and Bowel Foundation (UK). Available from: www.bladderandbowelfoundation.org.
Canadian Continence Foundation. Available from: www.canadiancontinence.ca.
Canadian Nurse Continence Advisors. Available from: www.cnca.ca.
Canadian Urological Association. Available from: www.cua.org.
Canadian Women's Health Network. Available from: www.cwhn.ca.
Overactive Bladder Support Sites:
Peeing Problem. Available from: peeingproblem.ca/en.
The Powder Room. Available from: www.powderroom.ca/en.
The Society of Obstetricians and Gynaecologists of Canada. Available from: www.sogc.org.
Urology Nurses of Canada. Available from: www.unc.org.
Suggested Readings
Frank C, Szlanta A. Office management of urinary incontinence among older patients. Can Fam Physician
2010;56:1115-20.
49. Reynolds WS, McPheeters M, Blume J et al. Comparative effectiveness of anticholinergic therapy for
overactive bladder in women: a systematic review and meta-analysis. Obstet Gynecol
2015;125:1423-32.
50. Shamliyan T, Wyman JF, Ramakrishnan R et al. Benefits and harms of pharmacologic treatment for
urinary incontinence in women: a systematic review. Ann Intern Med 2012;156:861-74.
51. Madhuvrata P, Cody JD, Ellis G et al. Which anticholinergic drug for overactive bladder symptoms in
adults. Cochrane Database Syst Rev 2012;1:CD005429.
52. Swinburn P, Lloyd A, Ali S et al. Preferences for antimuscarinic therapy for overactive bladder. BJU Int
2011;108:868-73.
53. Oefelein MG. Safety and tolerability profiles of anticholinergic agents used for the treatment of
overactive bladder. Drug Saf 2011;34:733-54.
54. Chapple C, Khullar V, Gabriel Z et al. The effects of antimuscarinic treatments in overactive bladder:
a systematic review and meta-analysis. Eur Urol 2005;48:5-26.
55. Andersson KE. Antimuscarinics for treatment of overactive bladder. Lancet Neurol 2004;3:46-53.
56. Staskin DR. Overactive bladder in the elderly: a guide to pharmacologic management. Drugs Aging
2005;22:1013-28.
57. Gibson W, Athanasopoulos A, Goldman H et al. Are we shortchanging frail older people when it
comes to the pharmacological treatment of urgency urinary incontinence? Int J Clin Pract
2014;68:1165-73.
58. Duthie JB, Vincent M, Herbison GP et al. Botulinum toxin injections for adults with overactive bladder
syndrome. Cochrane Database Syst Rev 2011;(12):CD005493.
59. Yokoyama T, Chancellor MB, Oguma K et al. Botulinum toxin type A for the treatment of lower urinary
tract disorders. Int J Urol 2012;19:202-15.
60. Raskolnikov D, Friedman FM, Etwaru DJ et al. The evaluation and management of persistent
nocturia. Curr Urol Rep 2014;15:439.
61. Ebell MH, Radke T, Gardner J. A systematic review of the efficacy and safety of desmopressin for
nocturia in adults. J Urol 2014;192:829-35.
62. Shamliyan TA, Kane RL, Wyman J et al. Systematic review: randomized, controlled trials of
nonsurgical treatments for urinary incontinence in women. Ann Intern Med 2008;148:459-73.
63. Cody JD, Jacobs ML, Richardson K et al. Oestrogen therapy for urinary incontinence in post-
menopausal women. Cochrane Database Syst Rev 2012;10:CD001405.
64. Hersh L, Salzman B. Clinical management of urinary incontinence in women. Am Fam Physician
2013;87:634-40.

Urinary Incontinence
Vaginal Symptoms, Hygiene and Infections
Laura-Lynn Pollock, BSc(Pharm), NARTC, Dip AC

Vaginal Physiology
The vagina is a fibromuscular structure that connects the external genitalia, or vulva, with the internal cervix
and uterus. It provides a channel for the removal of menstrual discharge, and the transverse folds or rugae
of the vaginal wall allow the flexibility of size and shape that are required for sexual intercourse and
childbirth.
Normal vaginal length is variable but is usually between 8 cm and 10 cm. The vagina is positioned at a 45°
angle, upwards and posteriorly. It is in close proximity to the bladder, urethra, perineum and rectum (Figure
1).1
A healthy vaginal environment is maintained by balancing many host factors including bacterial flora,
hormonal influences and the epithelial cells lining the vaginal wall. Estrogen induces the maturation of the
epithelial cells and stimulates the proliferation of epithelial basal cells. It also increases the cells' ability to
store glycogen, which is subsequently metabolized to lactic acid by the vaginal bacterium Lactobacillus
vaginalis, making the vagina acidic with a pH of 3.5–5.5. The nonpathogenic lactobacilli thrive in the acidic
environment while the proliferation of more troublesome microflora is controlled.2,3
Normal vaginal discharge varies in quantity, consistency and appearance throughout the menstrual cycle.
This discharge can be due to mucus production of the cervical glands, a transudate from the capillaries of
the vaginal walls and/or from other sources such as the uterus. Monthly hormone fluctuations are
responsible for the changing characteristics of the discharge. Sometimes the discharge is pasty, white and
scanty. Around the time of ovulation it is wet and slippery with the consistency of uncooked egg white. There
may be no apparent discharge on the days immediately after menses has stopped. Vaginal discharge
contributes to the health of the vagina and helps to maintain the pH and normal microflora. It should not
cause irritation, burning or itching.3,4
A mild odour may occur when vaginal discharge combines with secretions from glands in the vulvar area.
This odour should not be unpleasant or cause concern. Causes of unusual or unpleasant odour, genital
irritation or itching may include poor hygiene, allergic or sensitivity reactions to products used, vaginal
infections or a forgotten tampon.3,4,5,6
Figure 1: Female Reproductive System
Genital Hygiene
Introduction
Proper genital hygiene can be achieved very simply. The perineal area should be washed daily using warm
water and mild soap. The outer labia should be gently separated and the clitoral area cleaned and rinsed.
This area can be sensitive to perfumes and harsh ingredients in some soaps, so only mild products should
be used. After cleansing, the perineal area should be rinsed well with warm water to remove soap residue.
The vagina cleanses itself naturally through its secretions and does not require further cleansing.1,5
Normal genital hygiene does not require the use of specialized commercial products; however, a number of
products are marketed for just that purpose including vaginal douches, genital towelettes, cleansers and
feminine deodorant sprays. Genital hygiene products are used by women of all ages. Women often initiate
use of these products in their teens and continue into adulthood. Common reasons for their use include
menstrual hygiene, to reduce vaginal odour or vaginal irritation and for hygiene related to sexual
activity.7,8,9,10
Vaginal Douching
Douching is a process of instilling fluid into the vagina and flushing the cavity.
There are no substantiated benefits to routine douching and it can be associated with significant adverse
outcomes:
Douching may disrupt the normal vaginal environment, increasing the risk of irritation or
infection11,12,13
Douching may play a role in the development of ascending infections of the genital tract (e.g.,
salpingitis and pelvic inflammatory disease), ectopic pregnancy and possibly cancer of the
cervix11,12,13
Douching postcoitally is not an effective contraceptive method. It should be avoided until at least 6
hours after intercourse if a vaginal spermicide has been used, because douching can decrease the
effectiveness of the spermicide
Douching should also be avoided within 24 hours prior to a vaginal examination as this may hinder
detection of a vaginal infection.
Despite the possible adverse outcomes, douching is still used by women for a variety of reasons. To
decrease potential risks, it is important to provide sound advice to these women to help prevent adverse
effects. The use of suitable solutions and appropriate technique are important safety factors. Douching
should be avoided during pregnancy unless recommended by a healthcare practitioner. Douching is never
recommended as a contraceptive method or as a treatment for suspected vaginal infections.7,8,9,10
Examples of douching solutions include:
Plain warm water (simple and least likely to be harmful)

Vinegar and water (available commercially or can be made at home by adding 15–30 mL vinegar to 1 L
of warm water; produces transient decrease in vaginal microflora, similar to flushing with saline)13
Commercially available products containing perfumes, astringents, anti-infectives or proteolytics (these
ingredients do not increase effectiveness and can be irritating).
Instillation of the solution is by means of a vaginal syringe. There are two basic kinds of syringes—the
fountain syringe and the bulb syringe. The fountain syringe consists of a piece of tubing attached to a bag
(similar to a hot water bottle). A rounded plastic nozzle on the end of the tubing is inserted into the vagina.
Gravity creates the flow of the solution. The bulb syringe has no tubing; the vaginal tip is attached directly to
a small bag or bottle. The fluid is forced out of the bulb by squeezing the device or by the inward pressure
exerted by the distended walls of the bulb.
Proper technique is essential for safe douching. The pressure used to instill the solution should be gentle,
not forceful. Too much pressure may cause reflux of the solution (and possibly of bacteria) into the uterus
and increase the risk of pelvic infection. Correct technique is outlined in Vaginal Douching—What You Need
to Know.
Other Genital Hygiene Products

Genital towelettes (e.g., Tucks) are premoistened disposable wipes that are generally safe for occasional
use. They contain ingredients such as perfumes, astringents, emollients and anti-infectives and can be
irritating or cause allergic reactions. Mild soap and warm water is preferred for daily cleansing.
Genital washes (e.g., Summer's Eve) are liquid cleansers designed for daily use on the external genitalia.
They provide no additional benefit over mild soap and water, but there is no significant risk to their use.
Genital deodorant sprays (e.g., Summer's Eve FDS) contain ingredients such as perfumes and propellants
and are marketed to reduce genital odour. Their use is not recommended. They can mask the odour of
infections and cause treatment delays. Their use is associated with a high incidence of irritation and allergic
reactions. If used, they must not be applied to the inside of the vagina.
.....
Vaginal Dryness
Pathophysiology
It is common to have periods of time when vaginal lubrication is decreased. Low estrogen levels during
perimenopause or menopause, in the postpartum period, during breastfeeding and immediately following
menses may result in vaginal dryness. Tampons and certain medications can contribute to decreased
vaginal lubrication.
Medications associated with decreased vaginal lubrication include:14,15,16,17

Antiarrhythmics
Antidepressants
Antihistamines
Antihypertensives
Chemotherapy
Combined hormonal contraceptives
This decreased lubrication may be transient, or it may be long term, as is often the case for peri- or
postmenopausal women.1,4,18 For more information, see Menopause and Perimenopause.
Reduced estrogen levels cause thinning of the vaginal tissue, loss of collagen support, increased vaginal pH
and reduced production of vaginal lubrication even when sexual arousal has occurred. These changes are
associated with a number of vaginal symptoms, including:14,15,16,17
abnormal bleeding
discharge
dyspareunia (pain during sexual intercourse)
pruritus
slow production of lubrication with sexual arousal
vaginal dryness.
Goals of Therapy
Provide lubrication to vaginal tissue
Decrease symptoms associated with vaginal dryness
Increase level of comfort during sexual intercourse
Patient Assessment
The majority of women seeking advice and relief from vaginal dryness are in peri- or postmenopause.
Approximately 15% of perimenopausal and 29–57% of postmenopausal women experience symptoms of
vaginal dryness due to urogenital atrophy.14,18 It is reasonable to recommend a trial of nonprescription
vaginal lubricants or moisturizers to women with mild to moderate symptoms.15,16,17 Vaginal estrogen
therapy is more effective than lubricants and moisturizers for vaginal atrophy; therefore, women with severe
vaginal dryness or those who have been unresponsive to nonprescription measures should be referred to an
appropriate healthcare practitioner for assessment.19
Some relief from vaginal dryness may result from increasing blood flow to the pelvic region through sexual
stimulation. Any form of sexual excitement may help restore vaginal moisture. Intercourse is not necessary
to achieve this effect and should be avoided if it is painful.14,18
Ailments—Feminine Care Products: Vaginal Lubricants; Herbal and Natural Health Products: Single Entity.
First-line options consist mainly of vaginal lubricants and moisturizers. The promotion of condoms for safe
sex has been a catalyst for the increased use and development of products that enhance vaginal lubrication.
Nonmedicated, water-based products are safe for external and internal application. For vaginal dryness,
dyspareunia and for comfort during condom use, vaginal lubricants can be applied to the penis (on the
outside of a condom if one is worn) and the opening of the vagina during intercourse. The lubricants may be
water-based (e.g., K-Y Liquid/Jelly, AstroGlide), silicone-based (e.g., Astroglide X Silicone Liquid) or oil-based
(e.g., mineral oil, olive oil), but oil-based lubricants must not be used with latex condoms. Specialty
lubricants (flavoured, scented) are also available and some may contain ingredients such as methyl
salicylate that can provide a warm, stimulating sensation when applied. These additional ingredients may
increase the risk of sensitivity reactions to the products. Vaginal lubricants are short-acting and require
frequent re-application.14,15,16,17,18
Bioadhesive vaginal moisturizers, including polycarbophil gels (e.g., Replens) and hyaluronic acid gels (e.g.,
Gynatrof), attach to the vaginal epithelium and provide water and electrolytes to the cells. Other vaginal
moisturizers contain less adherent but equally effective ingredients such as pectin.20 Moisturizers have a
longer duration of action (2–3 days) than lubricants and are used on a regular basis, not immediately prior to
intercourse. Most women will gain maximum relief from symptoms if a vaginal moisturizer is applied every 3
days, but they can be applied more or less frequently if needed.16,17,19,20 Oil-based products should be
avoided because they can be irritating, difficult to remove, and can damage condoms, diaphragms and
cervical caps.
Hormonal supplementation with estrogens and progestogens is an option (see Menopause and
Perimenopause). Supplementation can be in the form of systemic hormone therapy or by vaginal application
of estrogen. Estrogen replacement reverses the vaginal changes seen with menopause and relieves
symptoms. Vaginal estrogen provides localized benefits with less systemic absorption/effects compared
with oral therapy. Concurrent progestogen supplementation is generally not required with low doses of
vaginal estrogen.21 Careful use of systemic hormone supplementation may be of benefit if there are a
number of menopausal symptoms to treat, but it is sometimes necessary to apply estrogen vaginally to
relieve vaginal symptoms even if the woman is also using systemic hormones.14,19,22,23 Topical
formulations include cream, vaginal tablets or ring-shaped devices that are inserted into the vagina and
deliver estrogen over an extended period. For further discussion of pharmacologic therapy for menopause,
consult the Compendium of Therapeutic Choices: Menopause.
Two small, short-term studies comparing the effects of vaginal application of bioadhesive polymers and
estrogen creams on atrophic vaginal changes demonstrated significant improvement in vaginal symptoms
with the use of both therapies.24,25 However, hormonal therapy (conjugated estrogen and dienestrol creams)
was significantly superior to bioadhesive polymers for most parameters measured. Similar results were
seen in a systematic review that examined vaginal estrogen and nonhormonal vaginal moisturizers for
genitourinary symptoms of menopause. Patients with 2 or more symptoms of vulvovaginal atrophy were
substantially more improved using vaginal estrogens, but those with just 1 symptom or only minor
complaints had similar symptom resolution with either estrogen or nonhormonal moisturizer.26

Black cohosh has been used in the management of menopausal symptoms including vaginal dryness,
although evidence of efficacy is lacking.27,28 It can cause nausea and headache and is contraindicated
in pregnancy and breastfeeding. The usual dose is 3–6 mL per day of a 1:5 tincture in 60% ethanol, or
500–1000 mg dried root or rhizome 2–3 times daily. Black cohosh should be used with caution in
women already taking estrogen and there is concern about its ability to potentiate the action of
antihypertensive drugs.28,29,30 Hepatotoxicity after the use of black cohosh supplements has been
reported, but analysis revealed that authentic black cohosh was not present in the supplement in most
cases. It is still unclear whether there is any connection between black cohosh ingestion and liver toxicity
but caution is recommended.31
.....
Vulvovaginal Candidiasis
Pathophysiology
The healthy vagina is host to a number of microorganisms including lactobacilli, streptococci, staphylococci,
Gardnerella vaginalis, Candida albicans (and other Candida species), anaerobes and Ureaplasma urealyticum.
The types and numbers of organisms vary due to such factors as age, sexual history, contraceptive method,
pregnancy, menstruation, antibiotic use, vaginal trauma (e.g., surgery) and even tampon use.3,22,32
Normally, the organisms live in balance in the vaginal environment without adverse effects. When this
harmony is disrupted, overproduction of host organisms or colonization by acquired pathogens can occur.
These changes set the stage for the development of vaginitis.32,33,34
Vaginitis describes a group of conditions that have similar symptoms but a variety of causes (Table
1).33,35,36 Treatment for vaginitis is specific to the cause, so the correct diagnosis is important. Self-
treatment is recommended for candidiasis only.
Table 1: Common Causes of Vaginitis

Cause Common Symptoms Vaginal pH
Vulvovaginal candidiasis Severe pruritus of vulva and vaginal areas <4.5
Stinging/burning
“Cottage cheese” discharge
Atrophy Vaginal discharge 7

Spotting
Soreness, burning
Bacterial vaginosisa “Fishy” odour 5–6

Creamy discharge (yellow/grey)
Trichomoniasis Frothy, wet discharge ≥6

Pruritus possible
a Bacterial vaginosis, the most common cause of vaginitis, is a polymicrobial infection involving deficiency of
lactobacilli and overgrowth of anaerobes, often (but not always) including G. vaginalis.36
Goals of Therapy
Relieve symptoms
Cure the infection
Prevent recurrence
Prevent misdiagnosis and delayed treatment of another condition
Patient Assessment
The decision to recommend treatment for vulvovaginal candidiasis must be made with care. Other forms of
vaginitis or sexually transmitted diseases (which can have similar symptoms)37 and allergic or adverse
reactions must be ruled out.
Further evaluation may be required if the patient:33,34,36,37

is prepubertal—vulvovaginal candidiasis is not common in this group and should be assessed
presents with vaginal symptoms for the first time
has an underlying illness such as diabetes
is pregnant
has a recurrence of vulvovaginal candidiasis within 2 months of the last episode (complicated cases
may require alternative drug therapy)
is immunosuppressed
is at risk of a sexually transmitted infection (STI), e.g., history of unprotected intercourse, multiple
partners, casual sexual encounters.
Potential predisposing factors for vulvovaginal candidiasis include:32,33,36

Chemical irritants, e.g., antiseptics, deodorants, soaps
Diabetes mellitus
Diet
Immunocompromised conditions, e.g., HIV/AIDS
Medications, e.g., antibiotics, chemotherapy, corticosteroids, hormone therapy, oral contraceptives,
tamoxifen
Menses
Pregnancy
Stress
Synthetic undergarments
Tight-fitting clothing
Women who have symptoms of vulvovaginal candidiasis and have had a previous diagnosis of candidiasis
may be candidates for self-treatment. An assessment approach is outlined in Figure 2.
Although there is no specific nonpharmacologic therapy for vulvovaginal candidiasis, preventive measures
are suggested for women wishing to avoid recurrences.
After bacterial vaginosis, Candida is the second most common cause of vaginitis. Many women experience
recurrent or resistant infections and may wish to control their symptoms by using preventive measures.
These include modifying potential predisposing factors where possible. There is a lack of evidence to
support the use of preventive measures such as clothing and dietary modifications but these may be worth
trying in recurrent, resistant cases and generally do not cause adverse outcomes.33,36
Good genital hygiene measures are important, to keep the tissue healthy and free from irritation. Vaginal
deodorants, douches, harsh soaps and perfumed products for genital use should be avoided, as irritation or
allergic reactions may occur. The regular use of products such as panty liners has not been shown to
promote the occurrence of vulvovaginal candidiasis.38
Tight clothing and synthetic underwear should be avoided, to minimize the development of warm, moist,
irritated skin where Candida can proliferate. Cotton underwear and loose-fitting undergarments and pants
are recommended.39
Dietary modifications have been tried with varying success. Although there is not a clear association
between Lactobacillus in the gut and vulvovaginal candidiasis, consumption of yogurt with active
Lactobacillus may decrease the incidence of recurrent infections.40,41 However, data are inconsistent42 and
more studies are required before this is recommended.
Severe dietary restrictions such as yeast-free and sugar-free diets can be tried but are difficult to follow and
no data support their efficacy.32
Table 3 outlines treatment options for uncomplicated vulvovaginal candidiasis.
Ailments—Feminine Care Products: Anti-infectives for Vaginal Fungal Infections.
After the woman has been assessed to verify the likelihood of vulvovaginal candidiasis, self-treatment can
be considered. Simple cases (women with a history of diagnosed vaginal candidiasis and no complicating
medical conditions who experience infrequent, mild to moderate symptoms)32,33 can be treated with
nonprescription vaginal antifungals. Short-course therapy (1–3 days) is effective and convenient and may
increase adherence due to its simplicity; however, results are not achieved more quickly than longer course
treatment (6–7 days). If successful, symptoms resolve within 7 days of beginning treatment.
Several vaginal antifungal products are available for vulvovaginal candidiasis. Vaginal antifungals are as
effective as oral antifungals for uncomplicated cases.50 [Evidence: SORT A] Effectiveness rates (80–90%)
are similar among azole agents and among products.49,50 Selection is determined by length of therapy
desired, dosage form preferred and the woman's previous experience.
Providing directions to ensure correct use and adherence with the chosen regimen is important. The
intravaginal product is usually administered at bedtime to increase contact time with vaginal tissue and
should be continued through menses if it commences during therapy. The complete course of treatment
should be used even if symptoms resolve before completion of the doses. If vulvar symptoms are
significant, a topical antifungal can be used adjunctively.
Single-dose oral therapy with fluconazole 150 mg is an effective option with high patient acceptability and
adherence; however, it has not been shown to be superior to vaginal antifungal therapy for uncomplicated
cases of vulvovaginal candidiasis.50 Oral fluconazole is well tolerated but it can cause side effects such as
nausea, abdominal discomfort and headache. A single dose of oral fluconazole 150 mg may be considered
as an alternative to topical azoles in women who are pregnant,45 and may also be used in women who are
breastfeeding as amounts excreted into breast milk result in lower exposure than with neonatal fluconazole
doses.46
Boric acid 600 mg capsules inserted intravaginally (not taken orally) once or twice daily for 14 days have
also shown variable success in the treatment of resistant vaginal candidiasis and may be an option for
women who do not respond to other therapies.43,48,51,52,53
Probiotics, such as Lactobacillus capsules, have been used orally and sometimes vaginally during courses
of oral antibiotic therapy, in an attempt to normalize the vaginal flora and prevent vaginal candidiasis.54 This
measure has had little success in decreasing vaginal candidiasis. If a woman wishes to use such a bacterial
replacement while taking antibiotics it will not interfere with therapy but the combination will likely not
reduce the occurrence of vulvovaginal candidiasis.54,55
A small study using probiotics in combination with oral antifungal therapy showed a significant benefit for
treating vulvovaginal candidiasis.56 More research is needed to confirm this result; however, there is no
reason to avoid the combination and there may be possible therapeutic benefits.
Patient preference will play a significant role in the final choice of therapy. If nonprescription therapy is
ineffective, the patient requires further examination and evaluation. More extensive therapy may be required.
Generally, the woman's sexual partner is not treated for candidal infection; however, in resistant or recurrent
vaginal infection it may be appropriate to recommend that the male partner use antifungal cream on his
penis daily for 7 days while the woman is receiving treatment.34 Refraining from sexual intercourse is also
recommended during treatment of resistant or recurrent vaginal infection.
Women with persistent symptoms that have not responded to self-treatment and women with severe
symptoms or complications (e.g., diabetes, pregnancy, immunosuppression, HIV infection and risk of other
STIs) require further assessment. Persistent cases may respond better to a longer course of therapy (6, 7 or
14 days) or a change in the antifungal product. Complicated cases must be treated individually.36
More extensive therapy may be required for persistent or recurrent cases of vaginal candidiasis or for
women with a greater tendency to develop candidiasis, e.g., immunocompromised patients. Therapy options
include switching to an alternative vaginal antifungal agent or longer courses of oral fluconazole or
intravaginal antifungal therapy.32,33,36,43
For more information on pharmacologic management of vulvovaginal candidiasis, consult the Compendium
of Therapeutic Choices: Sexually Transmitted Infections.
Prophylaxis of Vulvovaginal Candidiasis

Prophylactic therapy is sometimes prescribed for women with recurrent candidiasis. Single-dose daily or
weekly treatments of oral or topical therapy can help reduce recurrence of candidiasis. Resistance is a
concern with prophylactic azole treatment, so it should only be used in women with a persistent problem
and under the supervision of an appropriate healthcare practitioner. Vaginal boric acid capsules have also
been used monthly, e.g. 300 mg vaginally for 5 days at the beginning of each menstrual cycle.43
Prevention of Resistance
Reports of azole-resistant candidiasis are of concern.33,36,37,50 Self-treatment of vaginal infections is
among the speculated, yet unproven, causes; misdiagnosis and inappropriate or incomplete courses of
therapy may also be contributing to this resistance. Although not substantiated, it is a reminder that the
correct diagnosis and appropriate product use is important for proper self-treatment with vaginal
antifungals. Candida glabrata is one of the organisms found in resistant cases. C. glabrata tends to be found
in older women who have used azole therapy and who have a complicating underlying illness such as
diabetes.48 Women with recurrent symptoms of vaginitis may require further evaluation and therapy.36
Monitoring may be difficult for the healthcare practitioner, as women with vaginal candidiasis are often
otherwise healthy individuals who may not be regular clients. Ensure that the woman understands that
symptoms should resolve within 7 days of the start of treatment, no matter which regimen is used. She
should also know what to do in case of adverse effects or unsuccessful treatment (see Table 2).
Table 2: Monitoring of Therapy for Vulvovaginal Candidiasis

Therapy
Vulvovaginal itching Patient: Daily for 7–10 Eradication of If symptoms still present
and burning, days symptoms 1 wk after start of
dyspareunia, Healthcare therapy, patient requires
discharge practitioner: After 7 further evaluation and
days or next therapy.
pharmacy visit
Increased irritation As above As above Increased severity of

(may indicate adverse symptom(s) should be
reaction to product or assessed promptly;
inappropriate therapy) discontinue therapy and
ensure patient receives
further evaluation by
appropriate healthcare
practitioner.
.....
Toxic Shock Syndrome
Pathophysiology
Toxic shock syndrome (TSS) is a severe, life-threatening condition resulting from toxin-producing strains of
Staphylococcus aureus. Menstrual TSS became a significant concern with the introduction of
hyperabsorbable tampons in the late 1970s. These products had the ability to act as a reservoir for S.
aureus. Since the removal of these products from the market, the rate of TSS has decreased but it still poses
a risk to some women. The prevalence of menstrual TSS is 1–5 per 100 000 women of menstrual age per
year. It primarily affects young women (15–25 years of age) who use tampons during menses. Studies have
demonstrated that many women have antibodies that protect them from experiencing a reaction to the
toxin-producing S. aureus; however, some women have little innate protection.57
Tampon use is a major risk factor for the development of menstrual TSS. Other risk factors include the use
of diaphragms, cervical caps and contraceptive sponges.58
TSS can evolve clinically in rapid fashion, with a healthy woman becoming very ill in less than 12 hours.
Criteria for diagnosis include:58,59

Temperature >38.9°C
Hypotension
Rash with subsequent desquamation, particularly on the hands and feet
Involvement of at least 3 of the following systems: GI (vomiting, profuse diarrhea), muscular (severe
myalgia), mucous membranes (hyperemia), kidney (renal insufficiency), liver (increased enzymes),
blood (thrombocytopenia) and CNS (disorientation, confusion).
If left untreated, TSS can be fatal.
The role of the healthcare practitioner is to:
Educate patients about signs and symptoms of TSS and how to avoid it
Know how to ask key questions to identify possible TSS, so that it will be evident when urgent referral
for medical care is necessary60
Assess patients for possible TSS.
Patient Assessment
If a young woman presents with symptoms including fever, rash, vomiting, profuse diarrhea, dizziness
and/or faintness, TSS should be among the diagnoses considered. Ask the patient how the onset of illness
relates temporally to her menstrual period, whether she uses tampons and what contraceptive method she
uses. If symptoms are consistent with TSS and can be temporally associated with the use of tampons, a
diaphragm, cervical cap or contraceptive sponge, the intravaginal product should be removed immediately
and she should be referred for immediate medical attention. Treatment of TSS includes aggressive fluid
replacement and iv antibiotic therapy.58,59
Prevention
Risk reduction is the key to minimizing the occurrence of TSS that is associated with menstruation and/or
contraceptive devices. Advise women on proper use of tampons and barrier contraceptives that are
associated with an increased risk of TSS (see Toxic Shock Syndrome—What You Need to Know).
.....
Resource Tips
Canadian Women's Health Network. Keeping your vagina healthy. Available from: www.rcsf.ca/node/40797.
Our Bodies Ourselves. Available from: www.ourbodiesourselves.org.
Algorithms
Figure 2: Assessment of Patients with Vulvovaginal Candidiasis

Drug Table
Table 3: Treatment Options for Uncomplicated Vulvovaginal Candidiasis43

Effects
Drug Class: Azole antifungals, oral
fluconazole Uncomplicated Headache, Inhibitor of CYP2C9, Do not use in girls

infection: nausea, CYP2C19 and <12 y.44
Diflucan 150 mg po × abdominal pain, CYP3A4. Decreases
single dose diarrhea, serum concentration A single dose of
One,
dyspepsia, of clopidogrel's active oral fluconazole
CanesOral, Recurrent
dizziness. metabolites and 150 mg may be
generics
infection:b enhances the QTc- considered as an
150 mg every alternative to
$ prolonging effect of
72 h po × 3 topical azoles in
dronedarone,
doses; then women who are
fluoroquinolones,
150 mg weekly pregnant or
macrolides,
po × 6 methadone, pimozide, breastfeeding.45,46
monthsc quinine, tricyclic
antidepressants and
ziprasidone.
Decreases
metabolism of
atorvastatin,
benzodiazepines
(monitor for
increased toxic
effects), calcium
channel blockers,
clarithromycin,
colchicine,
erythromycin,
fentanyl, lovastatin,
phenytoin,
phosphodiesterase-5
inhibitors,
simvastatin,
solifenacin and
sulfonylureas.
Drug Class: Azole antifungals, topical

Effects
clotrimazole Uncomplicated Local May diminish Also available as

Canesten infection: hypersensitivity. therapeutic effect of an external cream.
Vaginal, 200 vaginal progesterone; External
generics mg/vaginal avoid concomitant application of
tablet: 1 tablet use. topical cream to
$ daily pv × 3 vulva once or
days or twice daily for up
500 to 7 days may
mg/vaginal reduce itching and
tablet: 1 tablet irritation.
pv × single Menstruation does
dose or not necessitate
avoiding or
1% vaginal stopping
cream: 1 treatment.
applicatorful Safe for use in
daily pv × 7 pregnancy; 7–14
days or days treatment
2% vaginal may be necessary.
cream: 1 Follow up required
applicatorful if symptoms
daily pv × 3 persist despite
days or treatment or recur
within 2 months of
10% vaginal
onset.
cream: 1
applicatorful
pv × single
dose
Recurrent
infection:b
intravaginal
azole × 7–14
days to
achieve
mycologic
remission,
followed by
clotrimazole
500
mg/vaginal
tablet once
monthly × 6
months
Effects
miconazole Uncomplicated Local Topical miconazole Also available as

Monistat, infection: hypersensitivity. may cause increased an external cream.
generics 100 mg/ovule: INRs and bleeding in External
1 ovule daily women taking application of
$ pv × 7 days or warfarin. If necessary topical cream to
400 mg/ovule: to use together, vulva once or
1 ovule daily consider more twice daily for up
pv × 3 days or frequent INR to 7 days may
monitoring, e.g., every reduce itching and
1200 2 days. Caution
mg/ovule: 1 irritation.
patient to watch for Menstruation does
ovule pv as a signs of bleeding.
single dose or not necessitate
May diminish avoiding or
2% vaginal therapeutic effect of stopping
cream: 1 vaginal progesterone; treatment.
applicatorful avoid concomitant Safe for use in
daily pv × 7 use. pregnancy; 7–14
days or days treatment
4% vaginal may be necessary.
cream: 1 Follow up required
applicatorful if symptoms
daily pv × 3 persist despite
days treatment or recur
within 2 months of
onset.
terconazole Uncomplicated Local May diminish Health Canada

Terazol 7, infection: hypersensitivity. therapeutic effect of safety warning:
generics 0.4% vaginal vaginal progesterone; Anaphylaxis and
cream: 1 avoid concomitant toxic epidermal
$$ applicatorful use. necrolysis (TEN)
daily pv × 7 have been
days reported during
terconazole
therapy. Therapy
should be
discontinued if
anaphylaxis or
TEN develops.47
Drug Class: Weak acids

Effects
boric acid Recurrent Local irritation None known Extemporaneously

vaginal infection:b prepared by filling
capsulesd #1 gelatin capsule
300–600 mg shell with 300–
capsule daily 600 mg boric acid
$$
pv × 14 days powder USP.
then maintain
with 300 mg NOT to be taken by
capsule pv × 5 mouth.
days per Contraindicated in
month pregnancy.
beginning the
Not first-line
first day of
therapy, although
menstrual
reported to be
cycle.
Continue for 6 >90% effective.48
monthsc Option if first-line
agents are
unsuccessful or
irritating or if
infection is
resistant.
a Cost for specified duration of treatment; includes drug cost only.

b Recurrent vulvovaginal candidiasis is defined as 4 or more episodes per year. Treatment for recurrent VVC requires
induction therapy followed immediately by maintenance treatment.
c Maintenance therapy should continue for 6 months. In cases of recurrence after completed therapy, induction and
maintenance treatment should be repeated. Recurrence rates on maintenance treatment are low but can be as high
as 50% in women off all therapy.
d Extemporaneously compounded preparation.

Legend: $ <$10 $$ $10–20
Suggested Readings
Boston Women's Health Book Collective. Our bodies, ourselves. New York: Simon & Schuster; 2011.
Nurbhai M, Grimshaw J, Watson M et al. Oral versus intra-vaginal imidazole and triazole anti-fungal
treatment of uncomplicated vulvovaginal candidiasis (thrush). Cochrane Database Syst Rev
2007;4:CD002845.
van Schalkwyk J, Yudin MH; Infectious Disease Committee et al. Vulvovaginitis: screening for and
management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis. J Obstet Gynaecol Can
2015;37:266-74.
Watson C, Calabretto H. Comprehensive review of conventional and non-conventional methods of

management of recurrent vulvovaginal candidiasis. Aust N Z J Obstet Gynaecol 2007:47:262-72.
References
1. Alcamo IE, Krumhardt B. The female reproductive system. In: Barron's anatomy and physiology: the
easy way. 2nd ed. Hauppauge: Barron's Educational Series; 2004. p. 492-500.
56. Martinez RC, Franceschini SA, Patta MC et al. Improved treatment of vulvovaginal candidiasis with
fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett Appl
Microbiol 2009:48:269-74.
57. Parsonnet J, Hansmann MA, Delaney ML et al. Prevalence of toxic shock syndrome toxin 1-
producing Staphylococcus aureus and the presence of antibodies to this superantigen in
menstruating women. J Clin Microbiol 2005;43:4628-34.
58. Goodman B. Body: toxic shocker. Health 2005;2:70.
59. Waldvogel F. Staphylococcus aureus (including toxic shock syndrome). In: Mandell GL, Bennett JE,
Dolin R, eds. Mandell, Douglas and Bennett's principles and practice of infectious diseases. 4th ed.
New York: Churchill Livingstone; 1995. p. 1765-7.
60. Issa NC, Thompson RL. Staphylococcal toxic shock syndrome. Suspicion and prevention are keys to
control. Postgrad Med 2001;110:55-6, 59-62.

Genital Hygiene for Women
Genital Deodorant Sprays
Toxic Shock Syndrome
Vaginal Douching
Vaginal Yeast Infection
Genital Hygiene for Women—What You Need to Know
Tips for good genital hygiene:
Wash the area around the outside of the vagina daily with warm water and mild soap. Rinse well.
The inside of the vagina cleanses itself naturally. It is not necessary to douche (rinse out) the inside of the
vagina. Douching is not recommended.
A mild genital odour is normal. You can keep the normal odour to a minimum by washing the genital area each
day.
Signs of a possible problem:
You shower, bathe or wash every day but find that you have:
Itching or irritation in the genital area

An unusual or unpleasant odour
Discomfort (burning, stinging) with sexual intercourse
You may have forgotten to remove a tampon or you may have an infection. See your health-care provider.
Genital Deodorant Sprays—What You Need to Know
You do not need to use genital deodorant sprays to keep the genital area clean. A daily shower or bath with a mild soap is all
that you need. However, if you do decide to use a genital deodorant spray, follow the instructions below.
Apply the spray to the external genital area only.

Apply the spray lightly. The propellants in the spray can cause an irritation if you use too much.
Shake the spray can before using it.
Hold the can at least 20 cm (8 inches) from your genital area.
Stop using the spray if it causes burning, irritation or itching. Wash the area with warm water and mild soap. If
symptoms don’t improve, see your health-care provider.
Do not spray inside the vagina.

Do not use the spray on irritated or broken skin.
Do not use the spray before sexual intercourse. The spray can irritate the penis or vagina.
Do not insert tampons right after you use the spray.
Do not use the spray when you’re wearing menstrual pads. It may cause irritation.
Toxic Shock Syndrome—What You Need to Know
What is toxic shock syndrome?
Toxic shock syndrome (TSS) is a life-threatening infection caused by bacteria that produce deadly toxins. Women who use
tampons, contraceptive sponges, diaphragms or cervical caps have a higher risk of developing TSS. A person who has TSS
needs immediate medical attention.
What are the symptoms of TSS?
People with TSS can suddenly become very sick, with symptoms such as:
High fever
A rash that looks like a sunburn
Low blood pressure (shock)
Dizziness or fainting
Vomiting
Diarrhea
Confusion
What you can do to lower your risk of TSS:
Use sanitary pads instead of tampons during your period, especially overnight.
If you use tampons, use the lowest absorbency that meets your needs. Change tampons 4–6 times a day and
never wear one for longer than 8 hours.
Do not use contraceptive sponges, diaphragms or cervical caps during your period.
If you recently had a baby, do not use tampons for postpartum bleeding. Do not use contraceptive sponges,
diaphragms or cervical caps while you are still bleeding. Have a diaphragm or cervical cap refitted 6–8 weeks
after you have a baby.
When should you see your health-care provider?
If you have the symptoms described above and think you might be at risk of TSS, see your health-care provider right away.
TSS is very dangerous. If it is not treated quickly it can be fatal.
Vaginal Douching—What You Need to Know
Some people think that douching keeps a woman’s vagina clean and smelling fresh. Some people think that douching can
prevent pregnancy. Both of these ideas are wrong.
You do not need to douche to keep your vagina clean. The vagina has its own natural cleaning system.
Douching does not work as birth control. You need to use birth control pills or another method to prevent
pregnancy.
Douching is not routinely recommended. Talk to your health-care provider before using a douche.
Is there a safe way to douche?
Find out when it is safe to douche and how to do it properly. Ask your health-care provider.
Do Not:
Do not douche if you think you have a vaginal infection. Signs of a vaginal infection are irritation around the
genitals or an unusual odour. See your health-care provider to find out if you have a vaginal infection. You will
need treatment to cure it.
Do not douche for at least 24 hours before having a vaginal examination.
Do not douche if you are pregnant, unless your health-care provider tells you it is okay.
Do not douche within 6 hours after having sex if you used a vaginal spermicide. Douching can prevent the
spermicide from working.
Do:
Avoid douching or use a douche only occasionally.

Avoid perfumed products.
Wash reusable douching equipment with hot water and soap every time you use it.
Learn how to douche safely. Follow the instructions below.
How do you use a douche safely?
To start:
If you are using a fountain syringe: Fill the bag with solution. Clamp off the tubing and hang the bag about 30
cm (1 foot) above your hips when you are sitting down. Don’t hang it higher than recommended. The pressure
will be too high.
If you are using a bulb syringe: Fill the bag or bottle with solution.
To use the douche:
Lie on your back in the bathtub with your knees bent.

Gently insert the plastic tip into the vagina. Slip it in as far as it will go comfortably.
Release the clamp on the fountain syringe or gently squeeze the bulb syringe to start the flow of fluid into the
vagina.
When enough fluid is inside, you will have a mild feeling of fullness in the pelvic area. Putting in too much fluid
or using too much pressure can push fluid into the uterus. This could cause irritation or infection.
Gently remove the plastic tip from the vagina. Use 1 hand to hold the labia (on either side of the opening to the
vagina) together. This will keep the fluid from flowing out of the vagina.
Release the labia after 1 minute and let the fluid come out.
Dispose of the douching equipment. If it is reusable, wash it with soap and hot water.
Vaginal Yeast Infection—What You Need to Know
What is a vaginal yeast infection?
A vaginal yeast infection is caused by a group of fungi called Candida. Yeast are tiny organisms that live in small numbers on
the skin and inside the vagina. The inside of the vagina is usually too acidic for a lot of yeast cells to grow, but if the
conditions change, yeast cells may begin to multiply.
Things such as your menstrual period, pregnancy, diabetes, antibiotics and birth control pills can change the environment
inside of the vagina so that yeast cells can grow more easily. Moisture and irritation of the vagina may also make it easy for
yeast to grow.
What are the signs of a yeast infection?
A yeast infection can be uncomfortable but it is usually not serious. You may have any of the following symptoms:
Itching and burning in the vagina and around the vulva (the skin that surrounds your vagina)
A white discharge from the vagina that looks like cottage cheese
Pain during sexual intercourse
Swelling of the vulva (you may not be able to notice this)
Vaginal yeast infections are very common. However, the symptoms are similar to other more serious conditions (e.g., some
sexually transmitted infections—STIs). Your health-care provider can tell you if you have a yeast infection or not. See your
health-care provider if:
You have never had a yeast infection before

You have diabetes or a weak immune system
You are pregnant
You are not sure if you have a yeast infection
Treating yourself for a yeast infection when you have another kind of infection can make the problem worse.
What is the treatment for a yeast infection?
If you have a yeast infection, your health-care provider may recommend medication that you can buy without a prescription.
The treatment will only work if you have a vaginal yeast infection.
Nonprescription medicine for a yeast infection may be a cream or an ovule (tablet) that is inserted inside the vagina using a
special applicator. You can also use the cream on the external skin to help reduce itching. The cream will only work if the
irritation is caused by the same infection. Another type of treatment is a capsule that you take by mouth. Make sure you know
the right way to take your medicine.
How to get the most from the treatment:
Read the directions completely before using the medication.

Use the medication exactly as recommended by your health-care provider.
If you use medication that you insert into the vagina, use it at bedtime to make sure it stays inside the vagina.
Continue treatment even if your period starts.
Use menstrual pads or panty liners to absorb leakage or if your period starts. Do not use tampons. They will
absorb the medication and decrease its effectiveness.
Finish all the treatment even if your symptoms go away before it is finished.
Wash reusable applicators with water and soap after each use. Throw out disposable applicators after 1 use.
Do not share applicators with anyone else.
Shower or bathe every day to keep the genital area clean.
How to feel more comfortable:
Wear loose-fitting, cotton underwear and pants.

Wear pantyhose with a cotton crotch piece.
Avoid tight-fitting clothes.
Is it okay to have sex while using the treatment?
Sex is not recommended during your treatment. Your partner could become infected.
The medicine used in the vagina to treat a yeast infection can decrease the effectiveness of spermicides,
condoms, diaphragms and cervical caps. These birth control methods will not work as well during a treatment
and for up to 3 days afterward.
When should you see your health-care provider?
Before using any nonprescription treatment for the first time. You must be sure that you have a yeast infection
before using any medicine.
If you still have symptoms 7 days after the treatment.
If the symptoms get worse during treatment.
What can you do to avoid getting another infection?
Reduce the amount of sugar in your diet.

Eat unsweetened yogurt.
Wear cotton underwear.
Don’t wear pantyhose or tights every day.
Wipe from front to back after using the toilet. This helps to keep bacteria out of your vagina.
Change out of a wet bathing suit or damp clothes as soon as you can.
Avoid coloured or perfumed toilet paper, bubble bath, feminine hygiene sprays and deodorant sanitary pads or
tampons.
Dental Conditions
Michelle Bourassa, BPharm, MSc, DMD

Introduction
This chapter describes the recommended therapy for several dental conditions: dentin hypersensitivity
(sensitive teeth), cracked tooth syndrome, postendodontic discomfort, acute alveolar osteitis (dry socket),
pulpal inflammation (pulpitis), necrotic pulp, apical periodontitis and periradicular abscess.
For patient assessment, see Figure 1. For an illustration of tooth anatomy, see Teething, Figure 1.
Dentin Hypersensitivity
Pathophysiology
Dentin is composed of tubules containing fluid that is in contact with the pulp. External stimuli disturb or
cause movement of this fluid, thereby activating the nociceptive receptors in the pulp and leading to the
perception of pain.1,2,3,4
Dentin hypersensitivity, also known as sensitive teeth, is characterized by sharp pain of short duration
arising from exposed dentin in response to various stimuli, which cannot be ascribed to any other dental
defect or pathology. Stimuli are generally chemical (e.g., acid), thermal (e.g., cold or hot drinks or food,
exposure to air), mechanical (e.g., toothbrush, probe, fingernails) or osmotic (e.g., sugar, gel) in nature.
Dentin hypersensitivity may be the result of root denudation (exposure) due to gingival recession from
toothbrush abrasion. Exposed dentin secondary to the loss of enamel in the crown area or at the radicular
level may be another cause of dentin hypersensitivity. Consumption of acidic foods and beverages
combined with vigorous tooth brushing with an abrasive toothpaste can lead to progressive erosion. Other
causes of dentin hypersensitivity include periodontal disease or surgery, erosion or abfraction (a noncarious
lesion) occurring at the cementoenamel junction on the lingual or buccal side of the tooth.
The prevalence of dentin hypersensitivity falls between 4% and 74% of adults.5 Dentin hypersensitivity is
encountered more often in young individuals with root exposure due to rapid gingival recession. Maxillary
teeth seem to be more frequently affected, and the buccal surface is the site most often involved.6
Prevention
Prevention plays an important role in managing this condition.1,3,4,7,8 If dentin hypersensitivity occurs,
advise patients to brush their teeth properly, to limit their intake of acidic foods and beverages, and to avoid
brushing within 2 hours of consuming acidic foods and beverages.5 Rinsing with water following intake of
acidic foods or drinks may also be beneficial. Encourage regular periodontal exams, with supportive therapy
when indicated.
Treatment
Evidence is insufficient to permit the development of evidence-based guidelines for the treatment of dentin
hypersensitivity. The following recommendations are based on clinical experience.9
Chemical or physical blockade of the patent dentinal tubules can prevent movement of the fluid they
contain. Physical blockade can be achieved with the application of fluoride varnishes, sealants, resins, glass
ionomer cements or soft tissue grafts. Chemical desensitization occurs when pulpal nociceptor activity is
blocked or the tubules are occluded with a protein precipitate, a crystallized oxalate deposit or potassium
formulations.
Desensitizing toothpastes exert their effect chemically and are the mainstay of treatment of this condition.
Recommend the use of a desensitizing toothpaste that contains potassium salts, oxalate salts, citrate salts,
strontium salts, stannous fluoride or arginine, applied with a soft or ultra-soft toothbrush. Several
commercially available products have received the Canadian Dental Association (CDA) seal of approval
(e.g., Sensodyne products, Colgate sensitive products, Crest Pro-health products).10,11 Advise patients that
it may take up to 2 weeks to achieve benefit from a desensitizing agent.4
Dental professionals may also apply highly concentrated fluoride preparations (varnishes or solutions) or
oxalate salt preparations, which often provide pain relief soon after administration. In resistant or recurrent
cases, the dentist may employ physical techniques to achieve a fast and more sustained resolution of the
pain.
Ailments—Dental Products: Dentifrices.
.....
Cracked Tooth Syndrome
Pathophysiology
Sudden pain that occurs on biting and ceases after the pressure is withdrawn is a classic sign of a cracked
tooth.3,12,13 The pain may be sharp, intense and of short duration, and may occur when eating or when
biting on an object (e.g., pencil). Although the usual stimulus is biting, some patients experience sensitivity
to thermal changes (particularly cold) or upon exposure to sweets.14 The pain may originate from the pulp
or the periodontium.
A cracked tooth can occur as a result of trauma, extensive filling, or when an intact tooth with an opposing
cusp is occluding against a marginal ridge or a foreign body such as a lingual barbell typically worn by
individuals with tongue piercings.
Treatment
Various restorative techniques are used to treat cracked teeth.15 The prognosis depends on the type and the
extent of the crack. A poor prognosis is associated with fractures occurring below the level of the alveolar
bone; in these cases extraction is usually required.
.....
Postendodontic Discomfort
Pathophysiology
Discomfort following endodontic treatment (root canal) is common. A root canal is a procedure used to
eliminate pulpal and periapical diseases. Root canals involve mechanical and biochemical debridement and
treatment of the canal system of the affected tooth. The apical extrusion of debris produced during the
procedure may lead to apical periodontitis.
Treatment
Usually the pain is mild and requires no medication, or can be relieved by mild analgesics (e.g.,
acetaminophen, ibuprofen).2,3 The results of a systematic review suggest that the combination of
acetaminophen and ibuprofen were most effective for acute pain relief.16 The discomfort generally
subsides within a few days. On occasion, an acute periapical abscess may occur, causing swelling and pain.
Advise the patient to consult a dentist immediately. Appropriate treatment includes draining the abscess
through the canal or by incision, and NSAIDs or a combination of analgesics for pain control. If signs of
systemic infection are present, the patient may require oral antibiotic therapy.
For more information regarding analgesics for dental pain and antibacterial regimens for orofacial
infections, consult the Compendium of Pharmaceuticals and Specialities: Drugs in Dentistry.
.....
Acute Alveolar Osteitis (“Dry Socket”)
Pathophysiology
Approximately 1–4% of patients undergoing surgical extraction of an impacted third molar (wisdom tooth)
will experience a painful complication known as acute alveolar osteitis.3,17 In this condition, the healing
process is delayed and the bone of the socket is exposed and extremely sensitive. The moderate to severe
pain that generally develops 1–3 days after the procedure is usually dull and throbbing, and often radiates to
the ear. The extraction site may have a foul odour and impart a bad taste in the mouth. Regional
lymphadenitis may be seen in some patients. Although rare, fever may accompany this condition and is self-
limiting if untreated. The etiology is not completely understood but increased fibrinolytic activity at the
surgical site is suspected. Some risk factors have been identified such as gender (female more than male),
site of extraction, traumatic extractions, age and smoking.18
Treatment
If patients experience acute alveolar osteitis, advise them to consult a dentist as soon as possible.
Treatment generally consists of gentle irrigation of the site with normal saline followed by the insertion of
an iodoform gauze soaked with eugenol for pain relief. The dressing may be changed every second to third
day for 3–6 days if the pain persists.
Even without intervention, the patient would not have any sequelae other than pain throughout the healing
period. Provide patients with adequate systemic analgesia such as an NSAID, acetaminophen with codeine
or another opioid or opioid combination if more appropriate. The results of a systematic review suggest that
the combination of acetaminophen and ibuprofen were most effective for acute pain relief.16
For more information regarding analgesics for dental pain, consult the Compendium of Pharmaceuticals and
Specialities: Drugs in Dentistry.
.....
Pulpal Inflammation (Pulpitis)
Introduction
The initial presentation of pulpitis is usually reversible; if untreated it may progress to an irreversible pulpitis.
Reversibility may be preserved if the cause is rapidly removed. Common causes include:2,8
Caries
Recent or faulty restoration (filling)
Trauma
Exposed tubules
Periodontal scaling
Pathophysiology
When the pulp is exposed to a noxious stimulus, an inflammatory reaction is induced with classic
manifestations of:
Vasodilation
Increased intracellular tissue pressure
Increase in cellular infiltrates
Increased levels of mediators such as prostaglandins and neuropeptides
Although initially reversible (enough reparative cells remain in the pulp to allow recovery), the condition
could continue to degenerate and may require endodontic therapy to stop the process.2,3,7,8,19,20 The main
symptom of reversible pulpitis is sensitivity or mild pain of brief duration after exposure to cold, sweets and
sometimes heat. The pain subsides upon removal of the stimulus. There is no spontaneous pain nor pain on
biting. Usually a cause can be identified on dental examination. The type of insult and the patient's age are
important factors that affect whether the pulp can recover. With aging, the ability of the pulp to repair itself
diminishes.
With irreversible pulpitis, the pain can occur spontaneously and it may be more prolonged on exposure to
the initial stimulus. Irreversible pulpitis results from significant pulpal injury (e.g., from caries, trauma or
cumulative effect of multiple restorations) and does not respond to removal of the causative factor.2,7
Treatment
Reversible pulpitis is treated by correcting the cause.2,3,7,8,21 If patients experience discomfort following a
recent restoration or periodontal scaling, reassure them that the symptoms should diminish and disappear
over a 3-month period. Symptomatic treatment (e.g., desensitizing toothpaste) may help, and symptoms
should be monitored. If the discomfort worsens or lasts longer than 3 months, the patient should seek
dental advice.
Caries is treated by removing the decay and placing a filling to occlude the dentinal tubules (see Teething). If
the cavity is extensive and the exposed pulp is carious, the pulpitis is classified as irreversible. In these
cases the treatment of choice is a root canal.
In some cases, extraction may be necessary. Pain is usually controlled with nonprescription analgesics (e.g.,
acetaminophen, ibuprofen or naproxen sodium), but may require prescription doses of NSAIDs.3,21 The
results of a systematic review suggest that the combination of acetaminophen and ibuprofen were most
effective for acute pain relief.16
There is insufficient evidence to support the benefits of antibiotics for irreversible pulpitis.22
.....
Pulp Necrosis
Pathophysiology
Pulp necrosis may result when inflamed pulp degenerates further; causes are the same as those seen with
irreversible pulpitis. At this stage, the reparative potential of the pulp is totally absent and the pulp lacks
viable tissue. Inflammation of the periapical tissue may be associated with pulp necrosis.2,8
Often, the patient has had a previous episode of symptoms related to irreversible pulpitis. Necrotic pulp
does not respond to stimuli such as cold or heat. The patient may feel spontaneous dull and throbbing pain
that worsens on lying down or that is stimulated by biting. The latter suggests inflammation of the periapical
tissues.2,8
Treatment
The appropriate treatment options are extraction or endodontic therapy (root canal). An NSAID or mild
analgesic may be prescribed by the dentist for a few days for possible postoperative pain or discomfort.2
The results of a systematic review suggest that the combination of acetaminophen and ibuprofen were
most effective for acute pain relief.16
.....
Acute Apical Periodontitis
Pathophysiology
Acute apical periodontitis is moderate to severe inflammation of the periodontal tissues located near the
apex of a tooth. Although it is most frequently associated with a pulpal condition (reversible or irreversible
inflamed or necrotic pulp), nonpulpal causes have been identified such as trauma or bruxism (grinding or
clenching the upper and lower teeth together, often while sleeping). The periapical tissues show a marked
inflammatory response with vasodilation and polymorphonuclear lymphocyte infiltration.2,21
Treatment
Acute apical periodontitis is treated by tooth extraction or endodontic therapy. If endodontic treatment is
chosen, canal debridement and drainage should be performed by a dentist on an emergency basis.
Generally, the drainage provides partial to complete relief of the pain. Some discomfort may persist for a few
days and can be managed with a mild analgesic or an NSAID. The results of a systematic review suggest
that the combination of acetaminophen and ibuprofen were most effective for acute pain relief.16 In more
severe cases, an opioid analgesic may be required, but use should be limited to a short period of time.2,21
For more information regarding analgesics for dental pain, consult the Compendium of Pharmaceuticals and
Specialties: Drugs in Dentistry.
.....
Chronic Apical Periodontitis
Pathophysiology
Chronic apical periodontitis is a type of granuloma with inflammation around the tooth’s root tip. Some
patients may be completely asymptomatic and unaware of the problem while others may experience mild
sensitivity on biting or percussion (i.e., the dentist may test by tapping on the tooth).2,21 The condition is
usually a low-grade, long-standing response to canal bacteria and irritants and presents as apical
radiolucency on x-ray, which is often when the condition is discovered. The cause is usually necrotic pulp,
but chronic apical periodontitis may be associated with other conditions including central giant cell
granuloma or cemental dysplasia.2,21
Treatment
Chronic apical periodontitis can be treated with the same modalities as necrotic pulp (extraction or root
canal). Analgesics can relieve some potential post-procedural discomfort and usually antibiotics are not
indicated.2,21
.....
Acute Periradicular Abscess
Pathophysiology
Acute periradicular abscess (also known as apical abscess) is an infection resulting from bacterial invasion
of the ligament space, surrounding the root and/or apex of the tooth. Patients experience severe pain when
biting or palpating the affected tooth.2In severe cases, the patient may present with fever, swelling of the
tissues adjacent to the tooth, and tenderness of the cervical and submandibular lymph nodes.23
Treatment
The gold standard of therapy is to remove the cause of infection and involves primarily establishing
drainage through the root canal by a dentist on an emergency basis.2,8,21 If swelling is severe, drainage of
pus through the fluctuant tissue may be required. Consider antibiotic therapy if the patient demonstrates
signs of systemic infection or is immunocompromised.
If swelling increases, incision and drainage may be required. If extraoral (i.e., outside the mouth) swelling
occurs, the patient requires an immediate dental consultation. If a dentist is not available, the patient should
seek medical assistance. Treatment with an antibiotic (e.g., amoxicillin or penicillin, clindamycin,
moxifloxacin or a combination of metronidazole with amoxicillin) is required.2,23,24 If not treated promptly,
the infection may spread to surrounding tissues and structures, spread throughout the body and serious
complications may arise. Severe cases have required drainage of extraoral pus.24,25
For more information regarding antibacterial regimens for orofacial infections, consult the Compendium of
Pharmaceuticals and Specialties: Drugs in Dentistry.
.....
Suppurative Apical Periodontitis or Chronic Periradicular Abscess
Pathophysiology
Suppurative apical periodontitis (also known as chronic periradicular abscess) refers to an apical lesion that
has established drainage through a sinus tract.8,26 The patient may report a “gumboil” or a foul taste in the
mouth. The culprit tooth is usually asymptomatic. Gentle pressure on the gum may expel pus from the
fistula.8,24,26 The cause of this condition is usually necrotic pulp.
Treatment
The usual treatment of suppurative apical periodontitis is tooth extraction or a root canal procedure.
Analgesics can relieve potential postprocedural discomfort and antibiotics are not usually indicated.2
.....
Algorithms
Figure 1: Assessment of Patients with Dental Conditions

Resource Tips
American Dental Association. Mouth Healthy: A-Z topics. Available from: www.mouthhealthy.org.
Canadian Dental Association. Your oral health. Available from: www.cda-adc.ca/en/oral_health/index.asp.
Suggested Readings
Miglani S, Aggarwal V, Ahuja B. Dentin hypersensitivity: recent trends in management. J Conserv Dent
2010;13:218-24.
Rossman LE, Hasselgren G, Wolcott JF. Diagnosis and management of orafacial dental pain emergencies.
In: Cohen S, Hargreaves KM, eds. Pathways of the pulp. 9th ed. St. Louis: Mosby Elsevier; 2006. p. 40-58.
References
1. West NX. Dentine hypersensitivity: preventive and therapeutic approaches to treatment. Periodontol
2000 2008;48:31-41.
2. Berman LH, Hartwell GR. Diagnosis. In: Cohen S, Hargreaves KM, eds. Pathways of the pulp. 9th ed.
St. Louis: Mosby Elsevier; 2006. p.2-39.
3. Holland GR. Management of dental pain. In: Lund JP, ed. Orofacial pain: from basic science to clinical
management. Chicago: Quintessence Pub.; 2001. p. 211-20.
4. Somerman M. Desensitizing agents. In: ADA/PDR guide to dental therapeutics. 5th ed. Chicago:
American Dental Association; 2009. p. 339-50.
5. Miglani S, Aggarwal V, Ahuja B. Dentin hypersensitivity: recent trends in management. J Conserv
Dent 2010;13:218-24.
6. Splieth CH, Tachou A. Epidemiology of dentin hypersensitivity. Clin Oral Investig 2013;17:S3-8.
7. Bender IB. Pulpal pain diagnosis–a review. J Endod 2000;26:175-9.
8. Rossman LE, Hasselgren G, Wolcott JF. Diagnosis and management of orafacial dental pain
emergencies. In: Cohen S, Hargreaves KM, eds. Pathways of the pulp. 9th ed. St. Louis: Mosby
Elsevier; 2006. p. 40-58.
9. Al-Sabbagh M, Harrison E, Thomas MV. Patient-applied treatment of dentinal hypersensitivity. Dent
Clin North Am 2009;53:61-70.
10. Davies M, Paice EM, Jones SB et al. Efficacy of desensitizing dentifrices to occlude dentinal tubules.
Eur J Oral Sci 2011;119:497-503.
11. Maldupa I, Brinkmane A, Rendeniece I et al. Evidence based toothpaste classification, according to
certain characteristics of their chemical composition. Stomatologija 2012;14:12-22.
12. Lynch CD, McConnell RJ. The cracked tooth syndrome. J Can Dent Assoc 2002;68:470-5.
13. Banerje S, Mehta SB, Millar BJ. Cracked tooth syndrome. Part 1: aetiology and diagnosis. Br Dent J
2010;208:459-63.
14. Mathew S, Thangavel B, Mathew CA et al. Diagnosis of cracked tooth syndrome. J Pharm Bioallied
Sci 2012;4:S242-4.
15. Lubisich EB, Hilton TJ, Ferracane J. Cracked teeth: a review of the literature. J Esthet Restor Dent
2010;22:158-67.
16. Moore RA, Wiffen PJ, Derry S et al. Non-prescription (OTC) oral analgesics for acute pain- an
overview of Cochrane reviews. Cochrane Database Syst Rev 2015;11:CD010794.
17. Noroozi AR, Philbert RF. Modern concepts in understanding and management of the “dry socket”
syndrome: comprehensive review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2009;107:30-5.
18. Kolokythas A, Olech E, Miloro M. Alveolar osteitis: a comprehensive review of concepts and
controversies. Int J Dent 2010;2010:249073.
19. Germain L. Differential diagnosis of toothache pain. Part 1, odontogenic etiologies. Dent Today
2012;31:92-7.
20. McClannahan SB, Baisden MK, Bowles WR. Endodontic diagnostic terminology update. Northwest
Dent 2011;90:25-7.
21. Carrotte P. Endodontics: Part 3. Treatment of endodontic emergencies. Br Dent J 2004;197:299-305.
22. Fedorowicz Z, van Zuuren EJ, Farman AG et al. Antibiotic use for irreversible pulpitis. Cochrane
23. Siqueira JF, Rocas IN. Microbiology and treatment of acute apical abscesses. Clin Microbiol Rev
2013;26:255-73.
24. Baumgartner JC, Hutter JW, Siquiera JF. Endodontic microbiology and treatment of infections. In:
Cohen S, Hargreaves KM, eds. Pathways of the pulp. 9th ed. St. Louis: Mosby Elsevier; 2006. p. 580-
609.
25. Furst IM, Ersil P, Caminiti M. A rare complication of tooth abscess–Ludwig's angina and
mediastinitis. J Can Dent Assoc 2001;67:324-7.
26. Roberts G, Scully C, Shotts R. Dental emergencies. In: Scully C, ed. ABC of oral health. London: BMJ
Books; 2001. p. 35-8.

Urgent Tooth Problems
Oral Hygiene, Dental Plaque and Caries

Dental Plaque
Pathophysiology
Dental plaque is defined as a gelatinous deposit that adheres to the tooth surfaces, fillings or dental
prostheses and is not removed by rinsing with water. Plaque is composed of aerobic and anaerobic bacteria
in a matrix of bacterial or salivary glycoproteins and dextrans. Dental plaque is also referred to as
“biofilm”.1,2 Deposition of plaque may occur on all surfaces of the teeth and may be recognizable within 24
hours. The area with the highest predilection for accumulation of plaque is the interproximal space of the
molars and premolars, followed by the interproximal space of the anteriors and finally by the facial surfaces
of the molars and premolars. Other areas of accumulation are the gingival margins along with pits and
fissures.2 For an illustration of dental anatomy, see Teething, Figure 1.
When freshly cleaned teeth are exposed to saliva, a layer of salivary glycoproteins adheres to the surface of
the teeth. Oral microorganisms can attach to the glycoproteins or to the tooth enamel itself. Sticky dextrans
and levans produced by the bacteria constitute the matrix that permits colonization and aggregation of
more bacteria. Initially, plaque is made of gram-positive cocci and rods; with time, gram-negative rods and
spirochetes join the existing microorganisms and the volume of plaque increases.3
Dental plaque can be divided into 2 types based on its location relative to the gum (supragingival or
subgingival). Supragingival plaque is usually white to yellow in colour. When present in small amounts, it can
be detected around the collar of the tooth with a probe or disclosing solution. When the volume is large, the
eye can easily identify it.3,4
Subgingival plaque is a key factor in the development of periodontal diseases. On the tooth surface of
subgingival plaque, the initial constituents and stages of plaque formation may be the same as for
supragingival plaque. The plaque surface adjacent to the gingiva is, however, somewhat different. The
structure appears less dense; the matrix is reduced and bacteria are more free.
Microbiology of Plaque
The microbiology of dental plaque varies greatly on an individual basis and from one area to another in the
same mouth. Gram-positive bacteria predominate and are mainly from the Streptococcus and Actinomyces
species. Gram-negative organisms such as Veillonella and Neisseria are also found, to a lesser extent.
Facultative anaerobic streptococci represent a significant proportion of bacteria encountered in plaque. The
types and relative amounts of microorganisms evolve with time, eventually producing an ecologic
environment favouring anaerobes.3,5,6,7 With progression of periodontal disease, anaerobic gram-negative
bacilli become more dominant.3,4
Consequences of Plaque
The presence of plaque plays an important role in 2 pathologic processes in the mouth, the development of
caries (cavities) and periodontal diseases.4,5,8,9 Therefore, effective removal of supragingival dental plaque
on a continuous daily schedule is essential to dental and periodontal health throughout life.10 Subgingival
plaque can be removed only with a professional cleaning.
Cariogenic Effect
Dietary sucrose increases plaque formation and the resulting plaque is more cariogenic. Studies have
shown that ingestion of sucrose favours the colonization and aggregation of microorganisms on teeth
and prosthetic devices. Streptococcus mutans and lactobacilli play a primary role in cariogenic plaque.
They act by metabolizing sucrose into an acid that causes demineralization of the enamel and, with time,
tooth decay.5,8
Periopathogenic Effect
To initiate and maintain periodontal disease, plaque has to be present at the tooth surface. The
pathogenic role of dental plaque is described in Periodontal Conditions: Gingivitis and Periodontitis.
Calculus
Dental calculus (tartar) is defined as the calcification of existing plaque deposits on the teeth or any other
hard surface in the mouth (fillings, fixed or removable prostheses).3 It can be located supragingivally or
subgingivally. When visible, it has a yellowish colour that may be darkened by dietary or exogenous
pigmentation (e.g., coffee, tea, red wine, smoking). Its formation starts in areas close to the salivary gland
openings, i.e., lingual (tongue) side of the lower incisors and the buccal (cheek) side of the upper molars.
When located under the margin of the gingiva, the calculus often takes on a dark colour and is very adherent
to the cementum of the tooth.
The surface of the calculus is usually rough and favours plaque retention, subsequently leading to irritation
and periodontal inflammation.
The presence of dental plaque is a prerequisite for calculus formation. In most patients, calcification occurs
within 48 hours in newly formed plaque. The amount of calculus being formed varies greatly from one
individual to another, and depends on many factors such as the composition of saliva and the concentration
of certain enzymes. Therefore, control of calculus formation begins with controlling plaque formation.
Calculus requires removal by a professional, with ultrasonic, sonic or sharp instruments. In contrast,
supragingival plaque can be controlled with good oral hygiene.
Plaque Control
Mechanical Methods
Mechanical removal of plaque may be achieved by brushing the teeth after every meal and at bedtime,
and by flossing once a day, preferably at bedtime. Plaque removal is more effective when toothpaste is
used;8,9 fluoride-containing toothpaste is recommended for caries prevention. In some patients, tools
such as interproximal or interspace single-tufted brushes, dental sticks (wood or plastic), handles with a
rubber tip or wide spongy floss (e.g., Superfloss) may be helpful for removing plaque from areas difficult
to access with a toothbrush and floss.2,9,11 These devices can also be useful for patients with
orthodontic braces, dental implants, wide spaces between teeth or fixed dental prostheses such as
bridge work.
Irrigating devices (e.g., dental water flosser, irrigation syringe) can also be useful for patients with
bridges or orthodontic appliances, after oral surgery, or for patients who do not have good manual
dexterity. They can remove food debris and possibly some plaque.12 Therefore, they can be
recommended as adjunctive devices only. Some studies suggest that a greater reduction of gingival
inflammation may result from subgingival irrigation with chlorhexidine by the dentist.13,14
Table 1 presents a nonexhaustive list of devices and their role in removing plaque.
9,15,16
Table 1: Dental Cleaning Devices
Device Role
Toothbrush Removes plaque from buccal (cheek) and lingual (tongue)

sides and occlusal (biting) surfaces of the teeth
Dental floss Removes plaque from interproximal surfaces (between the

teeth)
Interdental brush, interproximal Removes plaque from concave root surfaces when
brush attachment loss (detachment of the gingiva due to bone
Toothpick loss) is present, and from other difficult-to-reach areas
Rubber tip
Stimulator (rod curved at one Removes plaque by applying contouring pressure to

end with a sharp rubber tip) hyperplastic gingival papillae (noninflammatory enlargement
of the gingivae)11
Tooth Brushing
The most recommended tooth brushing technique is the sulcular method, which focuses on removal
of the plaque adjacent to and within the sulcus (see Teething).8,14,16 It is a very effective method for
the removal of plaque, particularly from the gingival area of the tooth and gingival crevice (sulcus).
The minimum brushing time required to effectively remove plaque is 2–3 minutes.8,15,17 The tongue
should be brushed as well. The technique is described in detail in the patient information section at
the end of the chapter.
Toothbrushes
A suitable toothbrush is one with soft or extra-soft, flexible, rounded bristles that can penetrate into
the gingival crevice to effectively remove plaque without causing trauma to soft and hard tissues. It
should also be small enough to easily reach all areas of the mouth.13,14,16 Toothbrush replacement is
recommended every 3 months, or as soon as the bristles start to splay.16 Studies have found no
consistent superiority of one manual toothbrush over another for either plaque removal or gingival
inflammation reduction.2,15
Mechanical/powered toothbrushes simulate manual tooth brushing in various ways, such as side-to-
side or circular motion. A Cochrane systematic review found that powered toothbrushes are superior
to manual toothbrushes at removing plaque and reducing gingival inflammation, and are not more
likely to cause injuries to gingivae. Long-term benefits of this for dental health are unclear.10,18 The
use of a mechanical brush may be beneficial when manual technique has failed, for patients with
limited dexterity or for patients with orthodontic appliances.2,13,15
Dentifrices
Dentifrices (toothpastes, gels, pastes) aid in:17
Minimizing the accumulation of plaque and tartar

Strengthening the enamel against caries (fluoride-containing products)
Cleaning the teeth by removing food debris and some stains
Freshening the mouth.
Dentifrices contain various combinations of the ingredients found in Table 2.19
Toothpaste with an attractive appearance and flavour encourages prolonged and regular use.17 The
market is overwhelmed with toothbrushes and toothpastes. Products that have obtained the
Canadian Dental Association (CDA) seal meet the needs of most patients. Particular needs should be
discussed with the patient's dentist or dental hygienist.
Minor Ailments—Dental Products: Dentifrices.
2,19
Table 2: Ingredients of Toothpastes
Ingredients Role Comments
Detergents, e.g., Foaming action may Adverse effects (e.g., development of

sodium lauryl sulfate, increase the solubility aphthous ulcers) in small percentage of
sodium-N-lauryl of plaque during patients may necessitate switching to a
sarcosinate brushing toothpaste without these agents.
Flavouring agents, Improve palatability Xylitol, in combination with fluoride in

e.g., xylitol, toothpaste, may also decrease tooth
sweetening agents decay.20
Humectants, e.g., Prevent toothpaste

glycerol, propylene from drying out
glycol, sorbitol
Thickening agents, Stabilize the

e.g., mineral colloids, formulation
natural gums,
seaweed colloids,
synthetic celluloses
Abrasive agents, e.g., Remove debris and May cause burning sensation, drying of
calcium carbonate, residual stains; mucous membranes, taste alteration,
dehydrated silica whiten teeth gingival abrasion or enamel erosion.
gels, hydrated Tooth powders contain about 95%
aluminum oxides, abrasives compared with 20–40% in
magnesium toothpastes and gels.
carbonate, phosphate
salts
Peroxides, sodium Whiteners May work by breaking down pigments

triphosphate that accumulate on or in the tooth
enamel. Some stains cannot be removed
by toothpastes containing these
whiteners, e.g., tetracycline staining,
mottling.
Pyrophosphates, zinc Prevent supragingival Mechanism not established. One

citrate calculus (tartar) hypothesis is the reduction of crystal
formation. Do not growth on the tooth surface through
affect subgingival or chelation of cations.
existing calculus.
Ingredients Role Comments
Stannous fluoride, Prevent gingival Reduce plaque accumulation through

triclosan, zinc citrate inflammation antibacterial and anti-inflammatory
activity.21 Stannous fluoride (and other
toothpaste ingredients) may interact with
chlorhexidine mouthwash, rendering both
agents less effective. Use them 30 min
apart.
Fluoride Reduces caries At a concentration of 1000–1100 ppm,

formation fluoride makes enamel more resistant to
demineralization. Excess amounts can
cause fluorosis (see Caries: Fluoride).
Flossing
Dental floss and tape, waxed or unwaxed, are equally effective for cleaning proximal surfaces.
Individual factors such as contacts (where 2 adjacent teeth come together), restorations, tooth
alignment and manual dexterity determine the type of floss used. The floss should slip easily
between the teeth and pass the margin of the fillings without tearing and becoming lodged in the
interproximal spaces. Unwaxed floss is suitable for most people; if it does not slide easily between
the teeth, a waxed floss can be used. For persistent problems with tearing or fraying, brands such as
Glide, Colgate Total or Eez-Thru can be tried.
Floss-holding devices have proven effective for some patients who have difficulty guiding the floss
with their fingers.14
Flossing should be performed every 24 hours along with brushing at least twice a day to prevent
plaque formation and subsequent caries and gingival inflammation.2,22
Chemotherapeutic Methods
Mouthwashes
In addition to plaque removal through brushing and flossing, chemical plaque control agents may be
desirable in some circumstances, and the use of a mouthwash has shown some benefits.23 A
number of commercially available mouthwashes may be good adjuncts to help control the
development of supragingival plaque and reduce subsequent gingivitis (Table 3). Oxygenating agents
(e.g., hydrogen peroxide, carbamide peroxide) are not recommended because of lack of efficacy and
potential adverse effects such as chemical burns of oral mucosa, decalcification of teeth and black
hairy tongue.
Minor Ailments—Mouth Products: Mouthwashes.
19,23,24
Table 3: Mouthwashes
Active Ingredient(s) Plaque and Comments
Gingivitis
Reduction
Cetylpyridinium Moderate Less effective than chlorhexidine. May cause
chloride 0.05% staining of teeth.
e.g., Cepacol
Chlorhexidine 0.12% High Gold standard. Requires prescription.

e.g., Peridex Limit use to once or twice daily; prolonged use
may cause tooth staining, taste disturbances and
discoloration of tongue.
Other adverse effects include local irritation or
allergic reactions.
Essential oils (thymol, High Use for 30 seconds twice daily; high alcohol
menthol, eucalyptol content in some products; may cause burning
and methyl salicylate), sensation, bitter taste or mucosal drying; not
e.g., Listerine recommended for children because of alcohol
content.
Care of Prostheses
Any removable prosthesis should be cleaned after eating and before going to bed. Plaque and tartar can
accumulate on artificial teeth as on natural ones. A denture brush or a soft toothbrush may be used to
clean the prosthesis using a denture cleaner or mild soap. The gums and the remaining teeth should be
cleaned carefully as well, with a soft toothbrush. For patients who wear a partial denture, special
attention should be paid to cleaning the teeth under the denture's metal clasps as plaque may become
trapped, increasing the risk of tooth decay.25 The toothbrush is not sufficient to remove debris; therefore,
immersing the device in a commercial denture cleaning solution is helpful.26,27,28 The patient should
soak the dentures for 15 minutes once daily in the cleaning solution, then brush them. Dentures with
metal parts are not compatible with all cleaning solutions; some solutions (e.g., sodium hypochlorite)
may cause corrosion of the metal. Household products should be avoided because they are too abrasive
for use on acrylic resin surfaces. Dentures should be cleaned over a basin filled with water so that if they
are accidentally dropped, the water will prevent breakage.
In spite of proper cleaning techniques, calculus may build up on some prostheses. Calculus should be
removed in the dental office with an ultrasonic cleaner.
Dentures should not be worn at night unless recommended by the dentist. They should be placed in a
container and soaked (completely covered) in lukewarm water to prevent dehydration and subsequent
dimensional change.
If the patient is not able to brush the dentures after the midday meal, they should at least thoroughly
rinse the dentures and mouth.
A Health Canada advisory in February 2010 alerted denture wearers to serious health risks associated
with excessive use of zinc-containing denture adhesives. Zinc is absorbed systemically when small
amounts of zinc-containing adhesives are swallowed during normal use. When these adhesives are
applied too frequently or in excessive quantity, over-exposure to zinc can lead to copper deficiency with
possible blood dyscrasias and/or neurologic symptoms. Caution patients to use adhesives only
according to the manufacturers' instructions and to consult their physician if they may have been
exposed to excessive amounts of zinc through overuse of these products.
Implants should be brushed and flossed carefully every day. All sides of the implant should be brushed,
and floss used with caution where the implant meets the gum line.25,29,30 Interdental brushes with nylon-
coated core wire may be helpful for maintaining dental implants.31 Advise patients to avoid using
brushes with hard and/or metal components, which can scratch the surface and allow for calculus
deposits to form.
.....
Caries
Dental Caries
Dental caries is a localized and progressive dissolution and destruction of the calcified tissues of the teeth
resulting from an infectious process.8,32
Bacteria from dental plaque (predominantly S. mutans and lactobacilli) are capable of producing organic
acids from the metabolism of dietary carbohydrates as well as from proteolytic enzymes. In response to the
decrease in pH at the tooth surface, calcium and phosphate ions diffuse out of the enamel, and
demineralization takes place. With an increase in pH, the process may be reversed. With time, disintegration
of the mineral component of enamel and dentin occurs, with subsequent formation of a cavity on either the
enamel surface or root surface.
Patients with xerostomia (dry mouth) have a higher risk and incidence of caries (see Dry Mouth).33
Early Childhood Caries

Any preschool-age child presenting with one or more decayed, missing (due to caries) or filled tooth
surfaces in a primary tooth is considered to have early childhood caries (ECC), a complex and chronic
disease. To reduce the risk of ECC, the Canadian Dental Association recommends dental assessments
for infants within 6 months of the first tooth erupting and at least by the age of 1 year.34 Healthcare
practitioners who identify children with ECC should refer them to a dental professional for further
assessment and care.
Enamel Caries
Initially, the lesion appears as a white spot due to demineralization of the enamel. With repeated
exposure to acid, the surface changes from smooth to rough and may become stained. If left untreated,
pitting and then cavitation occurs.8
Arrested Caries
Under favourable conditions, the lesional process in the enamel may stop, become inactive and may
even regress. Most of the time, arrested enamel caries have an opaque or dark appearance.8
Dentin Caries
In the dentin, demineralization is followed by bacterial invasion. Dentin has the ability to produce
secondary dentin in an attempt to protect the pulp, but its proximity to the pulp also represents a risk of
bacterial invasion into the tooth structure.8
Susceptible Sites
The sites on the tooth where plaque can accumulate are more prone to decay: pits and fissures (occlusal
surface for the posteriors and palatal surface for the anteriors), smooth enamel surfaces that shelter
cariogenic biofilm (proximal and cervical areas), and the root surface. Susceptibility is also dependent
upon host factors such as the volume and composition of the saliva.8,32
Caries Prevention
Caries Prevention
Prevention of caries can be achieved by:8,32
Protecting the teeth or strengthening the tooth structures

Reducing the amount of substrate available to the bacteria
Removing plaque and calculus through mechanical or chemical procedures.
A combination of the following interventions can facilitate the goals of caries prevention:8,32,33,34,35
Dental assessment of infants within 6 months of eruption of first tooth and no later than 1 year of age
Regular professional dental care
Good, regular oral hygiene methods:
daily mouth cleaning or tooth brushing for all infants, including those who are breastfed36
Diet low in sugar and dietary acids
Topical and/or systemic fluorides
Optimize salivary flow.
Caries Treatment
Depending on caries risk and incidence, some therapeutic modalities may be recommended:8,35,37,38
Modification of the diet in order to limit the substrate, e.g., favouring a noncariogenic diet and limiting
exposure to sucrose
Modification of microflora, e.g., antibacterial mouthwash, topical fluoride
Plaque disruption, i.e., good oral hygiene involving brushing, flossing, use of other aids
Modification of tooth surface, e.g., topical or systemic fluoride, smoothing of tooth surface
Stimulation of salivary flow, e.g., sugarless gum, xylitol-containing gum, saliva substitutes, medications
Restoration of tooth surfaces, e.g., sealing of pits and fissures at risk of caries, restoration of cavitated
lesions, correction of defects.
Pits and Fissures Sealants

The Canadian Dental Association supports the appropriate use of selective sealants based on an individual
caries risk assessment and diagnosis by the dentist, along with nutritional counselling, good oral hygiene
optimal fluoride exposure and regular dental exams.25,39
Role of Saliva
Saliva plays various protective roles against tooth decay:6,8,33
Acts as a reservoir of calcium, phosphate and fluoride ions and therefore favours remineralization
Contains IgA, lysozyme and peroxidase, which provide some antibacterial action
Decreases plaque accumulation and helps eliminate food debris
At high flow rates it has an alkaline pH, which helps buffer against organic acids.
Fluoride
The use of fluoride to prevent and control dental caries is well documented, safe and effective.35,40,41,42
Systemic fluoride improves the crystallinity and decreases the acid solubility of enamel formed in the pre-
eruptive phase of tooth development. In addition, it may affect tooth anatomy and reduce the risk of caries
associated with pits and fissures in the teeth. Locally administered fluoride benefits the enamel by reducing
demineralization and promoting remineralization of early caries. The resulting remineralized enamel has
improved resistance to acid attack. In the presence of fluoride, acid production by bacteria in plaque is
decreased, as is the synthesis of extracellular polysaccharides.8,24
The addition of fluoride to drinking water is recognized as a cost-effective public health measure.35 In areas
where the water is not fluoridated, supplemental oral fluoride may be considered.25,42,43
For caries prevention in children, the monitored use of fluoridated dentifrice is recommended until the child
is able to expectorate the dentifrice, which is around the age of 6 years.25,35,40 For a child between 3 and 6
years old, a pea-sized amount on the toothbrush is recommended; for a child younger than 3, only a rice
grain–sized amount of toothpaste should be used and the teeth should be brushed by an adult. To minimize
the risk of fluorosis, it is important for the caregiver to ensure the child does not swallow the toothpaste. A
nonfluoridated dentifrice may be considered until the age of 3.40 In some cases, based on the individual
child's risk of caries, professionally applied fluoride may be indicated. For children considered at high risk of
caries, home protocols may be recommended by the dentist on an individual basis.35,42
CDA does not recommend the routine use of fluoride supplements before the eruption of the first permanent
tooth. In individual cases where the benefits outweigh the risk of dental fluorosis, practitioners may
recommend supplements to young children at appropriate doses. To minimize the risk of dental fluorosis, all
other sources of fluoride should be carefully assessed to ensure that total fluoride intake does not exceed
0.05–0.07 mg/kg body weight.35
After the eruption of the first permanent tooth the risk of dental fluorosis is decreased and fluoride
supplement in the form of lozenges or chewable tablets could be considered as the fluoride would be
delivered locally (intra-orally). Lozenges and chewable tablets should be used preferentially over drops for
their local action. A lozenge or chewable tablet containing 1 mg of fluoride delivers the same amount of
fluoride as 1 g (average amount used) of a 1000 ppm fluoride toothpaste.35
Excessive amounts of fluoride may result in dental fluorosis, which typically manifests as white specks on
the child's teeth. It is a permanent cosmetic alteration of the enamel; there is no evidence that it affects the
health of the child. It affects mainly younger children.33 To minimize the risk of fluorosis, the total daily dose
of fluoride should not exceed 0.05–0.07 mg/kg of body weight.42
Fluoride mouthwashes could be recommended to patients at high risk of developing caries, as a preventive
measure. The CDA does not recommend this measure for patients under 6 years of age.35
Other forms of fluoride may be applied professionally (fluoride gels, foams and varnishes) in infants and
adult patients at high risk of developing caries.35,41,42
For most Canadians the other forms of fluoride supplements (chewable tablets, lozenges, drops) are not
recommended. They may be indicated for high-risk individuals in nonfluoridated communities when fluoride
is not obtained in other forms (toothpaste) and after a careful analysis of the total amount from all other
sources has been completed.35
Children who may be at higher risk of caries due to orthodontic or prosthodontic appliances or reduced
salivary function, or children with high caries activity, should be considered for fluoride supplements.40
Gastric distress, headache and weakness have been reported in cases of excessive ingestion. Allergic
reactions such as rash and other idiosyncratic reactions have been rarely reported.40 When taken as
directed, no adverse effects have been reported.40
To prevent overdoses, no more than 120 mg of fluoride should be dispensed per household at one time.40
Fluoride tablets should be taken with a glass of water or juice. Calcium from milk or other dairy products
may bind with fluoride causing both to be poorly absorbed.40
.....
Resource Tips
Canadian Dental Association. Available from: www.cda-adc.ca.
Perry DA. Plaque control for the periodontal patient. In: Newman MG, Takei HH, Klokkevold PR et al., eds.
Carranza's clinical periodontology. 11th ed. St. Louis: Saunders; 2012. p. 452-60.
Suggested Readings
Ritter AV, Eidson RS, Donovan TE. Dental caries: etiology, clinical characteristics, risk assessment, and
management. In: Heymann HO, Swift EJ, Ritter AV, eds. Sturdevant's art and science of operative dentistry. 6th
ed. St. Louis: Elsevier/Mosby; 2013. p. 41-88.
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3. Manson JD, Eley BM. The oral environment in health and disease. In: Manson JD, Eley BM, eds.
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4. McHugh WD. Dental plaque: thirty years on. In: Newman HN, Wilson M, eds. Dental plaque revisited :
oral biofilms in health and disease : proceedings of a conference held at the Royal College of
Physicians, London, 3-5 November 1999. Cardiff: BioLine; 1999. p. 1-4.
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6. Marsh PD, Bradshaw DJ. Microbial community aspects in dental plaque. In: Busscher HJ, Evans LV,
eds. Oral biofilms and plaque control. Australia: Harwood Academic; 1998. p. 43-55.
7. Jones CG. Chlorhexidine: is it still the gold standard? Periodontol 2000 1997;15:55-62.
8. Ritter AV, Eidson RS, Donovan TE. Dental caries: etiology, clinical characteristics, risk assessment,
and management. In: Heymann HO, Swift EJ, Ritter AV, eds. Sturdevant's art and science of operative
dentistry. 6th ed. St. Louis: Elsevier/Mosby; 2013. p. 41-88.
9. Perry DA. Plaque control for the periodontal patient. In: Newman MG, Takei HH, Klokkevold PR et al.,
eds. Carranza's clinical periodontology. 11th ed. St. Louis: Saunders; 2012. p. 452-60.
10. Perry DA. Plaque control for the periodontal patient. In: Carranza FA, Newman M G, Takei HH et al.,
eds. Carranza's clinical periodontology. 10th ed. St. Louis: Saunders Elsevier; 2006. p. 728-48.
11. West NX, Moran JM. Home-use preventive and therapeutic oral products. Periodontol 2000
2008;48:7-9.
12. Gorur A, Lyle DM, Schaudinn C et al. Biofilm removal with a dental water jet. Compend Contin Educ
Dent 2009;30:1-6.
13. Forgas L. Plaque control. In: Fedi PF, Vernino AR, Gray JL, eds. The periodontic syllabus. 4th ed.
Philadelphia: Lippincott Williams & Wilkins; 2000. p. 75-85.
14. Wilson TG, Kornman KS. Treating plaque-associated gingivitis. In: Wilson TG, Kornman KS, eds.
Fundamentals of periodontics. Chicago: Quintessence Pub.; 1996. p. 319-47.
15. Handcock EB, Newell DH. Preventive strategies and supportive treatment. Periodontol 2000
2001;25:59-76.
16. Manson JD, Eley BM. Prevention of periodontal disease. In: Manson JD, Eley BM, eds. Outline of
periodontics. 4th ed. Oxford: Wright; 2000. p. 132-44.
17. Forward GC, James AH, Barnett P et al. Gum health product formulations: what is in them and why?
Periodontol 2000 1997;15:32-9.
18. Yaacob M Worthington HV, Deacon SA et al. Powered versus manual toothbrushing for oral health.
19. Mariotti AJ, Burrell KH. Mouthrinses and dentifrices. In: American Dental Association. ADA guide to
dental therapeutics. 2nd ed. Chicago: ADA Pub.; 2000. p. 211-29.
20. Riley P, Moore D, Ahmed F et al. Xylitol-containing products for preventing dental caries in children
and adults. Cochrane Database Syst Rev 2015;3:CD010743.
21. Riley P, Lamont T. Triclosan/copolymer containing toothpastes for oral health. Cochrane Database
Syst Rev 2013;12:CD010514.
22. Sambunjak D, Nickerson JW, Poklepovic T et al, Flossing for the management of periodontal
diseases and dental caries in adults. Cochrane Database System Rev 2011;12:CD008829.
23. Stoeken JE, Paraskevas S, van der Weijden GA. The long-term effect of a mouthrinse containing
essential oils on dental plaque and gingivitis: a systematic review. J Periodontol 2007;78:1218-28.
24. Jackson RJ. Metal salts, essential oils and phenols–old or new? Periodontol 2000 1997;15:63-73.
25. Canadian Dental Association. Available from: www.cda-adc.ca. Accessed December 2015.
26. Gornitsky M, Paradisl I, Landaverde G et al. A clinical and microbiological evaluation of denture
cleansers for geriatric patients in long-term care institutions. J Can Dent Assoc 2002;68:39-45.
27. Nishi Y, Seto K, Kamashita Y et al. Examination of denture-cleaning methods based on the quantity
of microorganisms adhering to a denture. Gerodontology 2012;29:e259-66.
28. de Souza RF, de Freitas Oliveira Paranhos H, Lovato da Silva CH et al. Interventions for cleaning
dentures in adults. Cochrane Database Syst Rev 2009;7:CD007395.
29. McGivney GP, Castlebeery DJ, eds. McCracken's removable partial prosthodontics. 9th ed. St. Louis:
Mosby; 1995. p. 442-3.
30. American Dental Association. Available from: www.ada.org. Accessed December 2015.
31. http://www.ncbi.nlm.nih.gov/pubmed/23306040Todescan S, Lavigne S, Kelekis-Cholakis A.
Guidance for the maintenance care of dental implants: clinical review. J Can Dent Assoc
2012;78:c107.
32. Manton DJ, Drummond BK, Kilpatrick N. Dental caries. In: Cameron AC, Widmer RP, eds. Handbook
on pediatric dentistry. 3rd ed. Edinburgh: Mosby Elsevier; 2008. p. 39-52.
33. Bourassa M, Perusse R. Making their mouths water: general principles for treating xerostomia
patients. Canadian J Restorative Dentistry Prosthodontics 2008;1:24-7.
34. Canadian Dental Association. CDA position on early childhood caries. Ottawa (ON): CDA. Available
from: www.cda-adc.ca/_files/position_statements/earlyChildhoodCaries.pdf. Accessed December
2015.
35. Canadian Dental Association. CDA position on use of fluorides in caries prevention. Available from:
www.cda-adc.ca/_files/position_statements/fluoride.pdf. Accessed December 2015.
36. Canadian Dental Association. CDA position on breastfeeding and early childhood caries. Ottawa (ON):
CDA. Available from: www.cda-adc.ca/_files/position_statements/BreasfeedingandECC.pdf.
Accessed December 2015.
37. Deshpande A, Jadad AR. Impact of polyol-containing chewing gums on dental caries: a systematic
review of original randomized controlled trials and observational studies. J Am Dent Assoc
2008;139:1602-14.
38. Splieth CH, Alkilzy M, Schmitt J et al. Effect of xylitol and sorbitol on plaque acidogenesis.
Quintessence Int 2009;40:279-85.
39. Beauchamp J, Caufield PW, Crall JJ et al. Evidence-based clinical recommendations for the use of
pit-and-fissure sealants: a report of the American Dental Association Council on Scientific Affairs. J
Am Dent Assoc 2008;139:257-68.
40. Burrel KH, Chan JT. Systemic and topical fluorides. In: American Dental Association. ADA guide to
dental therapeutics. 2nd ed. Chicago: ADA Pub.; 2000. p. 230-41.
41. American Dental Association Council on Scientific Affairs. Professionally applied topical fluoride:
evidence-based clinical recommendations. J Am Dent Assoc 2006;137:1151-9.
42. Brearley Meser L, Mekertichian K. Fluoride modalities. In: Cameron AC, Widmer RP, eds. Handbook
on pediatric dentistry. 3rd ed. Edinburgh: Mosby Elsevier; 2008. p. 53-69.
43. Tubert-Jeannin S, Auclair C, Amsallem E et al. Fluoride supplements (tablets, drops lozenges or
chewing gums) for preventing dental caries in children. Cochrane Database Syst Rev
2011;12:CD007592.

Periodontal Conditions: Gingivitis and Periodontitis

Pathophysiology
Periodontal disease includes any pathologic process involving the periodontium, the tissues supporting the teeth
including the cementum, periodontal ligament, alveolar bone and gingiva (see Teething).1 Periodontal diseases are
divided into 2 categories: gingivitis and periodontitis. Gingivitis is inflammation of the gingiva whereas periodontitis
also involves the loss of connective tissue attachment and leads to the resorption of the tooth-supporting bone.2
Plaque is the most common cause of gingivitis and periodontitis. Plaque (also referred to as biofilm) is composed
of aerobic and anaerobic bacteria in a matrix of bacterial or salivary glycoproteins and dextrans.3,4 Many local and
systemic factors influence the periodontal inflammatory response to plaque (see Table 1).1,5,6,7,8
1,5,6,7,8
Table 1: Factors Influencing Periodontal Inflammatory Response
Local Factors Systemic Factors
Quality of oral hygiene Aging
Anatomic factors, e.g., root morphology, position of Endocrine imbalance (diabetes)

tooth in arch, root proximity
Iatrogenic factors, e.g., dental procedures, Hematologic disorders

restorative material, dentures, implants (peri-
implantitis)9
Traumatic injury, e.g., toothbrush abrasion, food Emotional or psychological stress

impaction, fingernail scratch, orthodontics
Chemical injury, e.g., ASA tablets applied to the Medications

gum5
Smoking Genetic disorders
Neoplasms, leukemia, multiple myeloma
Nutritional deficiencies
Pathogenesis of Periodontal Disease
Plaque or biofilm accumulate at the gingival or supragingival level.1,7,10,11 If not disrupted, it matures
microbiologically, and an inflammatory reaction can be initiated. The tissue reaction produces intermediate
products that serve as nutrients for gram-negative anaerobic bacteria. Concomitantly, the inflammation and
bacterial enzymes increase tissue permeability, allowing high molecular weight products from the bacteria to
penetrate the superficial tissues. Eventually, a balance between the bacterial challenge and the host response is
achieved, resulting in a chronic inflammatory process known as gingivitis.
Little is known about what causes the shift from stable, chronic gingivitis to periodontitis. The induction and
progression of periodontitis most likely involves disruption in the balance between the bacteria and the host
defenses. The bacterial population may change, or host defenses could be transiently or permanently altered by
such things as psychological stress, viral infection or smoking. Figure 1 illustrates progressive changes in the
development of periodontitis.
In the chronic state, gram-negative bacteria are found in the diseased sites. The predominant gram-negative
organisms are Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia,
Tannerella forsythensis (previously Bacteroides forsythus), Campylobacter rectus, Treponema denticola and
Fusobacterium nucleatum; many others may also be present.7 These bacteria produce factors that may be
responsible for tissue destruction and alteration of host defenses. Clinical signs of the disease may be partially
explained by the normal inflammatory and immune processes detected in the periodontal tissues. The
accumulation of bacteria induces the entry of chemotactic products into the tissue and stimulates the migration
of inflammatory and immune cells, e.g., polymorphonuclear cells, macrophages and lymphocytes. Dental plaque
located supragingivally is a reservoir for bacteria that can migrate subgingivally to form a biofilm in the gingival
crevice.12
Based on antibody patterns, there appears to be local control of the response. After prolonged exposure to
endotoxins, the protective effect of the antibodies tends to decline. Destruction of supragingival plaque through
frequent professional cleaning and good oral hygiene has been associated with a beneficial effect on the
subgingival bacterial population in moderately deep pockets.12 In addition, dental interventions such as scaling
and root planing have been shown to reactivate the antibodies and provide better protection. Enzymes such as
collagenases from the polymorphonuclear cells and fibroblasts, along with inflammatory mediators (e.g.,
interleukin-1-b and prostaglandin E2) may be potentially destructive to the connective tissues and bone. When
inflammation is allowed to become chronic, the epithelial cells in the junctional epithelium tend to migrate
toward the apex.
Figure 1: Progressive Changes in Periodontal Conditions
Prevalence
Gingivitis
Gingivitis is the most common form of periodontal diseases. Gingival inflammation in one or more sites of
the mouth can be seen in most people.1,13
The prevalence and severity of gingivitis vary significantly with age.8 In an epidemiological study of the U.S.
population, gingivitis was detected in early childhood, increased in frequency and severity in adolescence
and tended to decrease in frequency in adult groups.12 In young children, the gingiva around the deciduous
teeth seems to be resistant to plaque-induced inflammation.
From the age of 5 or 6 years to puberty, gingivitis is reported very frequently. In fact, chronic gingivitis has
been found in 80% of children under the age of 12 and in almost 100% at the age of 14. The incidence of
inflammation peaks at around age 12 for girls and age 14 for boys. It seems that the gingival tissue reacts
more severely to plaque deposition at puberty than after puberty.14
In a group of teens 15–19 years, 79% of subjects showed some gingival inflammation.15 The prevalence of
gingivitis was 54% in the 19–44 age group and declined to 44% at age 45–64 and to 36% in subjects 65
years or older. In most cases the gingivitis was limited to a few teeth.14,15
Acute necrotizing ulcerative gingivitis has a low prevalence in rich countries and a higher one in poorer
countries, often affecting malnourished children.14 In western countries, it is usually seen in the 16–30 age
group.
Periodontitis
A survey conducted in 2000 in Americans reported a prevalence of moderate to severe periodontitis in 4.2%
of an adult population.1
In children, periodontal disease is often associated with systemic conditions such as juvenile diabetes
mellitus, Down syndrome and many others.14
Risk Factors
Both prevalence and severity of periodontal disease increase with age and it seems to become clinically
significant in the fourth decade of life.8,14 For all age groups, the disease seems to be 1.5 times more prevalent
in men than in women. People with African background had twice the risk of having periodontal pockets,
compared with Caucasians.16 Socioeconomic status is also a contributing factor, since pockets and loss of
attachment are seen in a higher percentage of people with less than a Grade 12 education and in people with a
lower income.7,15,17 Genetic variation may explain why, in equal age groups, the transition from gingivitis to
periodontitis appears to be earlier and the disease more severe in Asians than in Europeans.8,14 Studies
estimate the risk of periodontitis in a smoker to be 2.5–7 times greater than in nonsmokers.7,18
It is difficult to reliably predict who will progress from gingivitis to periodontitis. Considerable variations have
been found in the clinical presentation and the rates of disease progression of chronic periodontitis.14
Consequences of Periodontal Disease on Systemic Health
The link between periodontal disease and systemic health is not as established as previously believed;19
investigations to determine a clearer relationship are underway.1 The following conditions are being studied:
Coronary heart diseases

Adverse pregnancy outcome
Poor glycemic control in patients with diabetes20
Stroke
Hyperlipidemia
Rheumatoid arthritis
Left ventricular hypertrophy
Obesity
Pulmonary infection
Mortality in the elderly
Blood cancers, kidney cancer, pancreatic cancer
Goals of Therapy
Reduce etiologic factors to reduce or eliminate inflammation
Prevent progression of periodontal disease
Restore and maintain optimal gingival and periodontal health
Motivate the patient to maintain a rigorous oral hygiene routine
Patient Assessment
Periodontal disease is assessed and managed by dentists, dental hygienists and periodontists. Encourage patients
to maintain good oral hygiene and to see their dentist regularly. The recommended frequency varies according to
the needs of each patient, but is never less than once yearly.
Gingivitis
Gingivitis is inflammation of the gingiva. There are many subtypes of gingivitis (Table 2), but they share the
following characteristics:1,21,22,23
Discoloration of gingival tissue (red or red-blue)

Signs of inflammation such as: bleeding on brushing or gentle probing; swelling or puffiness; loss of
stippling of the gingiva (surface becomes smoother); loss of gingival tone; firm and leathery texture of the
gingival tissue
The gingival margin is located at or coronal to the cementoenamel junction. Pseudo-pockets may be
encountered if swelling or hyperplasia is present
Probing depths are between 1 and 3 mm or more if swelling is present (Figure 1)
Pain is uncommon
22,24
Table 2: Classification of Periodontal Diseases
1. Gingival diseases
a. Dental plaque-induced gingival diseases
i. Gingivitis associated with dental plaque only
ii. Gingival diseases modified by systemic factors
A. Associated with the endocrine system
B. Associated with blood dyscrasias
iii. Gingival diseases modified by medications
A. Gingival hyperplasia (cyclosporine, phenytoin, calcium channel blockers)
B. Oral contraceptive-associated gingivitis
iv. Gingival diseases modified by malnutrition
b. Non-plaque-induced gingival lesions
i. Gingival diseases of specific bacterial origin
ii. Gingival diseases of viral origin
iii. Gingival diseases of fungal origin
iv. Gingival lesions of genetic origin
v. Gingival manifestations of systemic conditions
A. Mucocutaneous disorders
B. Allergic reactions
vi. Traumatic lesions
vii. Foreign body reactions
viii. Not otherwise specified
2. Chronic periodontitisa
3. Aggressive periodontitisa
4. Periodontitis as a manifestation of systemic disease
a. Associated with hematological disorders
b. Associated with genetic disorders
c. Not otherwise specified
5. Necrotizing periodontal diseases
a. Necrotizing ulcerative gingivitis
b. Necrotizing ulcerative periodontitis
6. Abscesses of the periodontium
a. Gingival abscess
b. Periodontal abscess
c. Pericoronal abscess (see Teething)
7. Periodontitis associated with endodontic lesions
8. Developmental or acquired deformities and conditions
a. Localized tooth-related factors that modify or predispose to plaque-induced gingival
diseases/periodontitis
b. Mucogingival deformities and conditions around teeth
c. Mucogingival deformities and conditions on edentulous ridges
d. Occlusal trauma
a May be generalized or localized.
Periodontitis
Periodontitis usually involves progression of gingivitis to include apical migration of the junctional epithelium,
attachment loss, loss of bone and pocketing.17,23,25 The usual clinical findings are:
Discoloration of gingival tissue (red or red-blue), or it may appear normal

Signs of inflammation such as: bleeding on brushing or probing; smooth, shiny gingival surface; loss of
stippling of the gingiva; suppuration on occasion; exposed root surface(s)
The gingival margin may be located anywhere relative to the cementoenamel junction
Probing depths are in the range of 4 mm or more (Figure 1)
Occasional pain
Gingivitis
The most common form of gingivitis is plaque-induced gingivitis.17,26,27 The other forms of gingivitis are very
rare; consult specialized references for more information.
Plaque control is the gold standard of treatment for gingivitis induced by dental plaque. See Oral Hygiene,
Dental Plaque and Caries.
Periodontitis
Periodontitis is treated by dental professionals. The progression of most periodontal diseases can be delayed or
stopped if the treatment plan achieves the following objectives:1,17,21,26,28,29
Removal of the causative factors

Reduction or elimination of all pockets and establishment of a normal sulcus depth
Restoration of physiologic gingival and bone architecture
Establishment of a functional occlusion by occlusal adjustment and restorative procedure
Maintenance of periodontal health through adequate plaque control by the patient and regular visits to the
dentist for close follow up and early intervention, in case of recurrence.
To achieve these objectives, the following interventions may be required:
Phase I
Scaling and root planing
Removal of overhanging restorations and other plaque retentive areas
Extraction of tooth or teeth
Preliminary occlusal adjustment (selective grinding of teeth to establish a stable bite) and
odontoplasty (modification of tooth contours)
Patient motivation and instruction in proper oral hygiene procedures
Evaluation of the results
Phase II
Surgical treatment. This phase includes all procedures designed to reduce or eliminate pockets by
resecting or relocating the gingival margin. It may also include the correction of alveolar bone defects
and mucogingival defects.
Phase III
Restorative treatment. When indicated, this step involves completion of occlusal adjustment,
operative dentistry, replacement of missing tooth or teeth by fixed and/or removable prostheses,
placement of dental implants and permanent splinting.
Phase IV
Maintenance treatment. Patients must continue maintenance therapy for their lifetime. Patients who
have been diagnosed with moderate to advanced periodontitis may require maintenance recalls as
often as every 3 months. The interval between recall appointments is dictated by the level of disease
control achieved by the patient at home.
Gingivitis
If plaque control cannot be achieved manually (e.g., due to lack of dexterity) or in patients who are systemically
compromised or post-operative, topical antimicrobial products may be used as an adjunct to regular plaque
control measures. The Canadian Dental Association has approved several mouth rinses to help in plaque control
and reduction of gingivitis. More information about these products and information for patients on proper
brushing, flossing and use of chlorhexidine mouthwash, can be found in Oral Hygiene, Dental Plaque and Caries.
Periodontitis
Dental Office Procedures
The effectiveness of scaling and root planing may be slightly increased when combined with irrigation of the
crevice with a antimicrobial agent such as chlorhexidine or povidone-iodine irrigation solution;30,31,32
however, they may stain the teeth. Iodine derivatives are rarely used in modern practice; they are
contraindicated in pregnant or nursing women, in patients with sensitivity to iodine, and those at risk of
hypothyroidism.33
Chlorine-releasing agents (e.g., sodium hypochlorite, chlorine dioxide chloramines-T) have also been
employed in periodontal therapy, although evidence for their long-term efficacy and safety is lacking.34
Topical Antibacterials
As an adjunct to tooth brushing and flossing, some dental practitioners recommend the use of chlorhexidine
0.12% mouthwash to reduce levels of periodontal pathogens in saliva. Chlorhexidine has shown efficacy vs.
broad spectrum bacteria, good adherence to tooth surfaces and oral mucosa, and a low potential for
irritation. It should be used under the supervision of a dentist and for a limited period of time, due to the
potential for reversible staining of the teeth and irreversible staining of fillings associated with prolonged
use.30,31,33,35 Patient information on the proper use of chlorhexidine mouthwash can be found in Oral
Hygiene, Dental Plaque and Caries.
Triclosan is available as a toothpaste and has shown moderate efficacy in vivo.36 Commercially available
toothpastes containing triclosan may reduce gingival inflammation and bleeding.37 Anti-infective agents
may also be placed subgingivally in vehicles that will allow slow release of the agent into the periodontal
pocket. Agents studied include chlorhexidine chips,38 tetracycline fibres, doxycycline gel,39 minocycline gel
and metronidazole gel. Only doxycycline gel (Atridox) is currently available in Canada. Studies have shown
little benefit when these products were used as adjuncts to mechanical therapy.40,41 They are not
recommended as single therapy.17,42,43,44
Systemic Antibacterials
Patients with plaque-induced gingivitis or chronic periodontitis usually respond well to mechanical
periodontal therapy. While little additional benefit is expected from the use of a topical anti-infective agent,
some patients may benefit from adjunctive systemic antibacterial therapy.30,44,45 The goal of antimicrobial
therapy is to destroy subgingival microorganisms that remain after local treatment. The best candidates for
systemic therapy are patients with continuing loss of periodontal attachment despite appropriate local
therapy, refractory periodontitis, early onset periodontitis, medical conditions predisposing to periodontitis,
or acute or severe periodontal infections, e.g., periodontal abscess, acute necrotizing
gingivitis/periodontitis.30,45
The adult oral dosages of antibacterials commonly prescribed for treatment of periodontitis are presented in
Table 3.
The optimal agent and dosage regimen, especially for refractory periodontitis, remain unclear. The selection
of an agent and dosage regimens have been established empirically rather than through systematic
research.
The adult oral dosages of antibacterials commonly prescribed for treatment of acute periodontal abscesses
are presented in Table 4. The benefits of systemic antibiotics for periodontal abscesses are unclear;46
therefore, patient selection for therapy should be considered on a case-by-case basis.47
To prevent progression to periodontitis and even eliminate gingivitis, encourage patients with gingivitis to
adhere to the oral hygiene regimen recommended by their dentist. Evidence suggests that toothbrushing in
addition to flossing regularly reduces gingivitis.48
Encourage patients who are undergoing treatment for periodontitis to keep their scheduled dental
appointments and to adhere to prescribed therapy.
Monitor the patient's use of chlorhexidine mouthwash to help minimize staining due to prolonged use.

See Oral Hygiene, Dental Plaque and Caries.
Resource Tips
American Academy of Periodontology. Patient resources. Available from: www.perio.org/patient-resources.
Drug Tables
Table 3: Antibacterial Regimens for Periodontitis43,45,47
Class Drug Dosage Adverse Effects Drug Interactions Costa
Fluoroquinolones ciprofloxacin 500 mg BID Abdominal pain, Concomitant $

po × 8 days nausea, vomiting, iron, antacids,
Cipro, photosensitivity, sucralfate reduce
Ciprofloxacin, dizziness, headache, absorption of
other drowsiness, fluoroquinolones;
generics insomnia, diarrhea, increased INR
pseudomembranous with warfarin.
colitis. Potential Consider
adverse effects on alternative in
developing cartilage; patients taking
avoid in children and CYP1A2
in pregnancy. substrates (e.g.,
duloxetine,
clozapine,
cyclobenzaprine),
due to inhibition
of CYP1A2 by
ciprofloxacin.
Avoid combining
with highest-risk
QTc prolonging
agents (e.g.,
amiodarone,
escitalopram,
fluoxetine).
Lincosamides clindamycin 300 mg TID Diarrhea, C. difficile Absorption of $

Dalacin C, po × 8 days infection. clindamycin
generics decreased by
kaolin.
Absorption of
erythromycin
decreased by
clindamycin.
Macrolides azithromycin 500 mg daily Infrequent GI May increase $$

Zithromax, po × 4–7 disturbance. concentration of
generics days colchicine,
dabigatran,
warfarin; dose
adjustments
and/or close
clinical
monitoring are
recommended.
Increased risk of
rhabdomyolysis
with simvastatin,
atorvastatin.
Avoid combining
with highest-risk
QTc prolonging
agents (e.g.,
amiodarone,
escitalopram,
fluoxetine).
Nitroimidazoles metronidazole 500 mg TID GI upset, urethral Disulfiram-like $$

generics po × 8 days burning, reaction with
250 mg TID discolouration of alcohol may
po × 8 days urine (dark or occur during
in reddish brown). treatment.
combination Increased
with concentration of
amoxicillin warfarin, dose
500 mg TID adjustments
po × 8 days and/or close
in clinical
combination monitoring are
with recommended.
ciprofloxacin Avoid combining
with highest-risk
QTc prolonging
agents (e.g.,
amiodarone,
escitalopram,
fluoxetine).
Penicillins amoxicillin 500 mg TID Usually well Penicillins may $

Amoxicillin, po × 8 days tolerated. increase serum
other Hypersensitivity concentration of
generics reactions (ranging methotrexate,
from minor rashes and decrease
to anaphylactic serum
shock). Nausea, concentration of
vomiting, diarrhea. the active
metabolite of
mycophenolate.
Tetracyclines
may decrease
the therapeutic
effect of
penicillins.
Tetracyclines doxycycline 100–200 mg GI effects; yeast Serum $$

generics once daily overgrowth; concentrations of
po × 21 days photosensitivity; tetracyclines may
may increase risk of be reduced by
azotemia; antacids,
pseudotumor calcium,
cerebri; magnesium and
contraindicated in iron salts,
pregnant women. carbamazepine,
chronic alcohol
ingestion,
phenobarbital
and phenytoin.
Methotrexate
concentrations
may be increased
by tetracyclines.
Avoid combining
with retinoic acid
derivatives due to
increased risk of
pseudotumor
cerebri.
Tetracyclines minocycline 100–200 mg GI effects; yeast Serum $$$

generics once daily overgrowth; concentrations of
po × 21 days photosensitivity; tetracyclines may
may increase risk of be reduced by
azotemia; antacids,
pseudotumor calcium,
cerebri; magnesium and
contraindicated in iron salts,
pregnant women. carbamazepine,
chronic alcohol
ingestion,
phenobarbital
and phenytoin.
Methotrexate
concentrations
may be increased
by tetracyclines.
Avoid combining
with retinoic acid
derivatives due to
increased risk of
pseudotumor
cerebri.
a Cost of specified course of treatment; includes drug cost only.

Legend: $ < $15 $$ $15–30 $$$ $30–45
Table 4: Antibacterial Regimens for Acute Periodontal Abscesses43,45,47

Class Drug Dosagea Adverse Drug Comments Costb
Lincosamides clindamycin Loading Diarrhea, C. Absorption of To be $$
Dalacin C, dose of difficile clindamycin considered in
generics 600 mg infection. decreased by patients with
po, kaolin, allergy to
followed absorption of beta-lactam
by 300 erythromycin antibacterials.
mg QID decreased by
po clindamycin.
Macrolides azithromycin Loading Infrequent GI May increase To be $$$

Zithromax, dose of disturbance. concentration considered in
generics 1 g po, of colchicine, patients with
followed dabigatran, allergy to
by 500 warfarin; dose beta-lactam
mg daily adjustments antibacterials.
po and/or close
clinical
monitoring are
recommended.
Increased risk
of
rhabdomyolysis
with
simvastatin,
atorvastatin.
Avoid
combining with
highest-risk QTc
prolonging
agents (e.g.,
amiodarone,
escitalopram,
fluoxetine).
Nitroimidazoles metronidazole 250 mg GI upset, Disulfiram-like May be used $

generics TID po urethral reaction with as
burning, alcohol may monotherapy
discolouration occur during or in
of urine (dark treatment. combination
or reddish Increased with
brown). concentration amoxicillin or
of warfarin, ciprofloxacin.
dose
adjustments
and/or close
clinical
monitoring are
recommended.
Avoid
combining with
highest-risk QTc
prolonging
agents (e.g.,
amiodarone,
escitalopram,
fluoxetine).
Penicillins amoxicillin Loading Usually well Penicillins may $$
Amoxicillin, dose of tolerated. increase serum
other 1 g po, Hypersensitivity concentration
generics followed reactions of
by 500 (ranging from methotrexate,
mg TID minor rashes to and decrease
po anaphylactic serum
shock). concentration
Nausea, of the active
vomiting, metabolite of
diarrhea. mycophenolate.
Tetracyclines
may decrease
the therapeutic
effect of
penicillins.
a
Treat for 3 days, then evaluate patient to determine whether further antibiotic therapy or dosage adjustment is required.
b Cost of 3-day supply; includes drug cost only.

Legend: $ < $3 $$ $3–6 $$$ $6–9
Suggested Readings
Cummins D. Vehicles: how to deliver the goods. Periodontol 2000 1997;15:84-99.
Dentino A, Lee S, Mailhot J et al. Principles of periodontology. Periodontol 2000 2013;61:16-53.
Flemmig TF. Periodontitis. Ann Periodontol 1999;4:32-7.
Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000 2001;25:8-20.
Slots J; Research, Science and Therapy Committee. Systemic antibiotics in periodontics. J Periodontol
2004;75:1553-65.
References
1. Dentino A, Lee S, Mailhot J et al. Principles of periodontology. Periodontol 2000 2013;61:16-53.

2. Armitage GC; Research, Science and Therapy Committee of the American Academy of Periodontology.
Diagnosis of periodontal diseases. J Periodontol 2003;74:1237-47.
4. Claydon NC. Current concepts in toothbrushing and interdental cleaning. Periodontol 2000 2008;48:10-22.
5. Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J
Periodontol 1992;63:322-31.
6. Socransky SS, Haffajee AD. Evidence of bacterial etiology: a historical perspective. Periodontol 2000
1994;5:7-25.
7. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000 2002;28:12-5.
8. Tessier JF, Baehni PC. Epidémiologie et étiologie des maladies parodontales. In: Bercy P, ed. Parodontologie:
du diagnostic à la pratique. Paris: De Boeck Université; 1996. p. 25-35.
9. Smeets R, Henningsen A, Jung O et al. Definition, etiology, prevention and treatment of peri-implantitis—a
review. Head Face Med 2014;10:34.
10. Kornman KS. The pathogenesis of periodontal diseases: an overview. In: Wilson TG, Kornman KS, eds.
11. Teughels W, Quirynen M, Jakubovics N. Periodontal microbiology. In: Newman MG, Takei HH, Klokkevold PR
et al., eds. Carranza's clinical periodontology. 11th ed. St-Louis: Saunders Elsevier; 2012. p. 232-70.
12. Burt B; Research, Science and Therapy Committee of the American Academy of Periodontology. Position
paper: epidemiology of periodontal diseases. J Periodontol 2005;76:1406-19.
13. Ronderos M, Michalowicz B. Epidemiology of periodontal diseases and risk factors. In: Rose LF, ed.
Periodontics: medicine, surgery, and implants. St. Louis: Elsevier Mosby; 2004.
14. Manson JD, Eley BM. Epidemiology of pariodontal disease (the size of the problem). In: Manson JD, Eley
BM, eds. Outline of periodontics. 4th ed. Oxford: Wright; 2000. p. 119-31.
15. Brown LJ, Loe H. Prevalence, extent, severity and progression of periodontal disease. Periodontology 2000
1993;2:57-71.
16. Oliver RC, Brown LJ, Loe H. Variations in the prevalence and extent of periodontitis. J Am Dent Assoc
1991;122(6):43-8.
17. Pihlstrom BL, Ammons WF. Treatment of gingivitis and periodontitis. Research, Science and Therapy
Committee of the American Academy of Periodontology. J Periodontol 1997;68:1246-53.
18. Muller HP, Stadermann S, Heinecke A. Longitudinal association between plaque and gingival bleeding in
smokers and non-smokers. J Clin Periodontol 2002;29:287-94.
19. Li C, Lv Z, Shi Z et al. Periodontal therapy for the management of cardiovascular disease in patients with
chronic periodontitis. Cochrane Database Syst Rev. 2014;8:CD009197.
20. Simpson TC, Weldon JC, Worthington HV et al. Treatment of periodontal disease for glycaemic control in
people with diabetes mellitus. Cochrane Database Syst Rev 2015;11:CD004714.
21. Wilson TG, Kornman KS. The periodontium in health and disease. In: Wilson TG, Kornman KS, eds.
22. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann
23. Gray J. Plaque-related periodontal diseases: pathogenesis. In: Fedi PF, Vernino AR, Gray JL, eds. The
periodontic syllabus. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 31-40.
24. American Academy of Periodontology Task Force Report on the Update to the 1999 Classification of
Periodontal Diseases and Conditions. J Periodontol 2015;86:835-8.
26. Pihlstrom BL. Periodontal risk assessment, diagnosis and treatment planning. Periodontology 2000
2001;25:37-58.
27. Jackson RJ. Metal salts, essential oils and phenols–old or new? Periodontology 2000 1997;15:63-73.
28. Gray J. Host defenses and periodontal disease. In: Fedi PF, Vernino AR, Gray JL, eds. The periodontic
syllabus. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 51-69.
29. Carranza FA, Takei HH. The treatment plan. In: Newman MG, Takei HH, Klokkevold PR et al, eds. Carranza's
clinical periodontology. 11th ed. St-Louis: Saunders Elsevier; 2012. p. 384-6.
30. Slots J, Jorgensen MG. Efficient antimicrobial treatment in periodontal maintenance care. J Am Dent Assoc
2000;131:1293-304.
31. Jorgensen MG, Slots J. Practical antimicrobial periodontal therapy. Compend Contin Educ Dent 2000;21:111-
4, 116, 118-20.
32. Eberhard J, Jepsen S, Jervoe-Storm PM et al. Full-mouth treatment modalities (within 24 hours) for chronic
periodontitis in adults. Cochrane Database Syst Rev 2015;4:CD004622.
33. Slots J. Primer for antimicrobial periodontal therapy. J Periodontal Res 2000;35:108-14.
34. Galvan M, Gonzalez S, Cohen CL et al. Periodontal effects of 0.25% sodium hypochlorite twice-weekly oral
rinse. A pilot study. J Periodont Res 2014;49:696-702.
35. Addy M, Moran JM. Clinical indications for the use of chemical adjuncts to plaque control: chlorhexidine
formulations. Periodontology 2000 1997;15:52-4.
36. Barnett ML. The role of therapeutic antimicrobial mouthrinses in clinical practice: control of supragingival
plaque and gingivitis. J Am Dent Assoc 2003;134:699-704.
37. Riley P, Lamont T. Triclosan/copolymer containing toothpastes for oral health. Cochrane Database Syst Rev
2013;12:CD010514.
38. Ciancio SG. Local delivery of chlorhexidine. Compend Contin Educ Dent 1999;20:427-32.
39. Garrett S. Local delivery of doxycycline for the treatment of periodontitis. Compend Contin Educ Dent
1999;20:437-40, 442, 444.
40. Hanes PJ, Purvis JP. Local anti-infective therapy: pharmacological agents. A systematic review. Ann
41. Bonito AJ, Lux L, Lohr KN. Impact of local adjuncts to scaling and root planing in periodontal disease
therapy: a systematic review. J Periodontol 2005;76:1227-36.
42. Cummins D. Vehicles: how to deliver the goods. Periodontol 2000 1997;15:84-99.
43. Ciancio S, Mariotti A. Antiinfective therapy. In: Newman MG, Takei HH, Klokkevold PR et al., eds. Carranza's
clinical periodontology. 11th ed. St-Louis: Saunders Elsevier; 2012. p. 482-91.
Teething

Pathophysiology
The normal primary dentition (also called deciduous or milk teeth) is composed of a total of 20 teeth,
divided as follows: 4 incisors, 2 canines (cuspids) and 4 molars on each arch. The complete permanent
(adult) dentition includes a total of 32 teeth: 4 incisors, 2 canines, 4 premolars and 6 molars in each
arch.1,2,3 Figure 1 represents the normal anatomy of an adult molar and its related structures.
Figure 1: Anatomy of a Molar
Table 1 presents the usual age range for tooth eruption. Figure 2 depicts the normal primary and permanent
dentition.
1,2,3
Table 1: Usual Tooth Eruption Times
Teeth Upper (maxillary) Lower (mandibular)
Primary
Central incisors 7–12 months 6–10 months
Lateral incisors 9–13 months 7–16 months
Canines (cuspids) 16–22 months 16–23 months
First molars 13–19 months 12–18 months
Second molars 25–33 months 20–31 months
Permanent
Teeth Upper (maxillary) Lower (mandibular)
Central incisors 7–8 y 6–7 y
Lateral incisors 8–9 y 7–8 y
Canines (cuspids) 11–12 y 9–10 y
First premolars 10–11 y 10–12 y
Second premolars 10–12 y 11–12 y
First molars 6–7 y 6–7 y
Second molars 12–13 y 11–13 y
Third molars (“wisdom teeth”) 17–21 y 17–21 y
Figure 2: Occlusal Surface of Primary Teeth (upper and lower) and Permanent Teeth (upper and lower)
Primary Teeth
The eruption of the primary teeth is accompanied by signs and symptoms in about two-thirds of
infants.4,5 Usually the symptoms are transient. They may appear up to 4 days prior to the emergence of
the tooth. The peak in incidence and severity is usually on the day of eruption or 1 or 2 days before.
These symptoms generally resolve within 3 days after eruption.4,5
For a few days prior to eruption, the gum overlying the tooth may show signs of inflammation such as
redness, irritation, swelling and tenderness. The child may have a greater tendency to rub the gum by
biting their fingers, lip, toys or some other object. This action induces more salivation and drooling, which
can cause some facial irritation or skin rash. The local inflammation may be sufficient to explain the
irritability of the child, which may manifest as agitation, restlessness, crying and insomnia. A meta-
analysis reported the most common symptoms associated with primary tooth eruption as: gingival
irritation (87%), irritability (68%), and drooling (56%).6 Other reported symptoms include a decrease in
appetite for solid food, increased thirst, mild increase in body temperature (up to 37.7°C),7 loose stools,
ear rubbing and nasal congestion.5,6,8,9
Symptoms associated with an erupting tooth may coincide with an infectious process. Do not overlook
the possibility of infection particularly when more severe symptoms are present. Fever, diarrhea,
vomiting or symptoms of upper respiratory tract infection require assessment; do not presume they are
caused by teething.1,2,4,5,10
Permanent Teeth
The eruption of a permanent tooth may be associated with the same gingival manifestations as with
primary teeth, but the symptoms are usually much less pronounced. There may be local inflammation on
the gum over and around the erupting tooth, from a few days prior to emergence of the tooth, to a few
days after eruption.11 Part of the gingiva may overlie the usually distal portion of the surface of the tooth
for a relatively long period of time before completely receding. This part of the mucosa is called the
operculum. Usually no symptoms result from its presence, but it can be problematic, particularly around
the third molars, in the presence of mechanical trauma or plaque. Severe inflammation and marked
swelling might then be seen at the operculum. This condition is called pericoronitis and is most often
seen in teenagers and young adults. The patient may present with localized or diffuse pain, swelling
and/or trauma at the operculum, bad breath and a foul taste in the mouth. When pus is present, the
condition is called pericoronal abscess, and immediate dental or medical attention is recommended
because the infection may spread into the oropharyngeal area and medially to the base of the tongue.12
Swelling may extend to the adjacent tissue, and the patient may experience limitation in opening the
mouth, lymphadenopathy and low-grade fever.5,11,13,14,15
Delayed Tooth Eruption
There is a wide range in eruption times of primary and permanent teeth, due to individual variation (see
Table 1). Developmental age is more important than chronological age in assessing delays in eruption. In
an otherwise healthy child, a delay of up to 6 months if a primary tooth is involved or up to 12 months in
the case of a permanent tooth is usually of no clinical significance.16,17 Delays can be caused by local
factors such as the presence of a tooth in the erupting path, insufficient space in the arch or a dental
infection. Rarely, systemic conditions or iatrogenic factors such as chemotherapy or radiotherapy of the
head and neck can delay tooth eruption. Table 2 summarizes the possible causes of delayed tooth
eruption. Consult a dentist when delays of more than 12 months are encountered.
10,17,18,19
Table 2: Causes of Delayed Tooth Eruption
Systemic Causes (infrequent) Local Causes Iatrogenic Causes
Down syndrome Lack of arch space Chemotherapy

Cleidocranial dysplasia Ankylosis of the predecessor Radiotherapy of the head
Congenital hypopituitarism Premature loss of the and neck
Congenital hypothyroidism predecessor
Gaucher's disease Cysts
Osteoporosis Supernumerary teeth (extra

teeth)
Ectodermal dysplasia
Hypovitaminosis D
Eruption Cysts
Occasionally, a localized, dome-shaped, fluctuant, bluish, swollen area, sometimes surrounded by
inflammation, appears on the gum overlying the crown of an erupting tooth. The space is filled with
tissue, fluid and blood. This condition is called an eruption cyst and is more often seen over erupting
molars. Eruption cysts may be encountered in the first and second decades and there is no gender
predilection.8,10,20
Goals of Therapy
Minimize pain, irritability and sleep disruption associated with teething pain
Prevent complications through involvement of medical or dental professionals when indicated for
systemic illness, eruption cysts, delayed tooth eruption, pericoronitis or pericoronal abscess
Patient Assessment
Table 3 lists circumstances in which referral to a dentist or physician is indicated.
Table 3: When to Refer Patients with Teething Problems

Condition Recommendation
Pericoronitis Dental consultation as soon as

possible
Pericoronal abscess Urgent dental or medical consultation
Delays of over 6 months in a primary tooth eruption or 12 Dental consultation as soon as

months in a permanent tooth eruption possible
Suspected systemic illness in a young child, e.g., fever, Medical consultation when appropriate
vomiting, diarrhea, symptoms of upper respiratory (these symptoms are not normally
infection associated with teething)
Eruption cysts that do not spontaneously drain, or that Dental consultation as soon as
cause discomfort and/or interfere with feeding possible
Treatment of Teething Pain
Local measures can help minimize a child's discomfort during tooth eruption.1,2,8,10 Something hard,
smooth and clean may be given to the child to bite and chew on, such as a frozen facecloth. Safe
teethers, cooled in the refrigerator before use, can be very effective in reducing the local symptoms. They
should not have any small parts that could break off and cause the child to choke. The Canadian Dental
Association recommends rubbing the back of a small, cold spoon on the gum (see Resource Tips).1
Avoid long-term contact with very cold items. Do not place anything in the child's mouth that could be a
choking hazard. Teething biscuits are not recommended because of their sugar content.
Ailments—Analgesic Products: Internal Analgesics and Antipyretics; Dental Products: Topical Analgesics
for Teething.
For teething pain in infants that is not relieved by nonpharmacologic measures, oral analgesics, such as
acetaminophen or ibuprofen, can be used at the usual analgesic doses (see Table 4).1,8,10 Systemic
analgesics should never be rubbed on the gum.
Although their use is controversial, topical anesthetic agents (benzocaine 7.5–10% in a gel formulation)
may be applied in a thin layer to the affected gum using a cotton swab or finger, up to 4 times daily.8,10
The duration of action is 30–45 minutes. Because of concern about disabling the gag reflex if the child
swallows the anesthetic, it is recommended that the caregiver wait for an hour before feeding the child, if
a local anesthetic has been applied to the gum. Methemoglobinemia is an uncommon but serious
adverse effect that has been reported with the use of benzocaine applied to the oral mucosa.21,22,23 This
condition affects oxygen delivery to tissues and is characterized by bluish discoloration of the skin,
nausea and fatigue, and can progress to stupor, coma and death. Avoid using benzocaine in patients
with hemoglobin or enzyme abnormalities that affect oxygen transport.
Treatment of Pericoronitis or Pericoronal Abscess

These conditions require a dental consultation for appropriate treatment. They can be treated by the dentist
with careful debridement of the area with curettage, followed by irrigation with physiologic saline solution,
chlorhexidine 0.12% solution or hydrogen peroxide 3%. Some cases require surgical removal of the
operculum, extraction of the involved tooth, or extraction or selective grinding of the opposing tooth.14
When systemic manifestations or extensive swelling are present, an antibacterial agent targeting gram-
negative anaerobes (e.g., penicillin, amoxicillin/clavulanate, clindamycin or metronidazole) is usually
prescribed along with irrigation and extraction.9,24,25
Analgesics (e.g., acetaminophen or ibuprofen) may be used to control the pain and decrease the fever when
present. The patient may be instructed to rinse at home with lukewarm salt water (about one-half teaspoon
of table salt in a cup of warm water) every 2–3 hours for 2–3 days.13,15
For more information regarding drug therapy for dental conditions, consult the Compendium of
Pharmaceuticals and Specialties: Drugs in Dentistry.
Treatment of Eruption Cysts

Eruption cysts usually rupture spontaneously. In rare cases, marsupialization (surgical excision of a small
amount of gum tissue from the roof of the cyst) under local anesthesia may be indicated if significant
discomfort or interference with feeding occurs.1,18,20
Drug Table
Table 4: Pediatric Analgesic Doses for Teething Pain
Analgesics acetaminophen 10–15 Uncommon with infrequent $

Atasol mg/kg/dose use and recommended dose.
Preparations, Q4–6H po or Chronic use and overdose
Tempra, pr PRN for associated with
Tylenol, symptom hepatotoxicity, nephropathy.
generics management; Potential for toxicity enhanced
maximum 75 if concurrent dehydration,
mg/kg/day prolonged fasting, diabetes
Do not mellitus, obesity, concomitant
exceed adult viral infection or family history
dose of hepatotoxic reaction.
NSAIDs ibuprofen Children ≥6 Uncommon with infrequent $

Advil Pediatric months: 5–10 use and recommended dose.
Drops, Motrin mg/kg/dose GI intolerance and bleeding.
Children's, Q6–8H po Skin rash, allergic reactions,
generics PRN for tinnitus.
symptom Reduced renal function, acute
management; renal failure, sodium and
maximum 40 water retention. Dehydration
mg/kg/day enhances risk of renal toxicity.
Do not
exceed adult
dose
Children <6
months: 5
mg/kg/dose
Q8H
a Cost of 1-day supply; available without prescription.
Legend: $ <$2
Resource Tips
American Dental Association. Available from: www.ada.org.
Suggested Readings
Massignan C, Cardoso M, Porporatti AL et al. Signs and symptoms of primary tooth eruption: a meta-
analysis. Pediatrics 2016;137(3):1-19.
Ramos-Jorge J, Pordeus IA, Ramos-Jorge ML et al. Prospective longitudinal study of signs and symptoms
associated with primary tooth eruption. Pediatrics 2011;128:471-6.
Twetman S, Garcia-Godoy F, Goepferd SJ. Infant oral health. Dent Clin North Am 2000;44:487-505.
References
1. Canadian Dental Association. Dental development. Available from: www.cda-

adc.ca/en/oral_health/cfyt/dental_care_children/development.asp. Accessed February 4, 2016.
2. Pinkham JR. The dynamics of change. In: Pinkham JR, ed. Pediatric dentistry: infancy through
adolescence. 4th ed. St. Louis: Elsevier Saunders; 2005. p. 166-205.
3. Cameron AC, Widmer RP, Street N et al. Eruption dates of teeth. In: Cameron AC, Widmer RP, eds.
Handbook of pediatric dentistry. 3rd ed. New York: Mosby Elsevier; 2008. p. 453-55.
4. Macknin ML, Piedmonte M, Jacobs J et al. Symptoms associated with infant teething: a prospective
study. Pediatrics 2000;105:747-52.
5. Ramos-Jorge J, Pordeus IA, Ramos-Jorge ML et al. Prospective longitudinal study of signs and
symptoms associated with primary tooth eruption. Pediatrics 2011;128:471-6.
6. Massignan C, Cardoso M, Porporatti AL et al. Signs and symptoms of primary tooth eruption: a
meta-analysis. Pediatrics 2016;137(3):1-19.
7. Jaber L, Cohen IJ, Mor A. Fever associated with teething. Arch Dis Child 1992;67:233-4.
8. Parkin SF. Some oral and dental diseases of childhood. In: Parkin SF, ed. Notes on paediatric
dentistry. Oxford: Wright; 1991. p. 170-82.
9. Wake M, Hesketh K, Lucas J. Teething and tooth eruption in infants: a cohort study. Pediatrics
2000;106:1374-9.
10. Noren J, Koch G, Rasmussen P. Disturbances in tooth development and eruption. In: Koch G, ed.
Pedodontics, a clinical approach. 1st ed. Copenhagen: Munksgaad; 1991. p. 250-74.
11. Nowak A, Crall J. Prevention of dental disease. In: Pinkham JR, ed. Pediatric dentistry infancy through
adolescence. 2nd ed. Philadelphia: W.B. Saunders; 1994. p. 192-208.
12. Meng HX. Periodontal abscess. Ann Periodontol 1999;4:79-83.
13. Peterson LJ. Principles of management of impacted teeth. In: Peterson LJ, ed. Contemporary oral
and maxillofacial surgery. 2nd ed. St. Louis: Mosby; 1993. p. 225-60.
14. Holland GR. Management of dental pain. In: Lund JP, ed. Orofacial pain: from basic science to clinical
management. Chicago: Quintessence Pub.; 2001. p. 211-20.
15. Abrams H, Jasper SJ. Diagnosis and management of acute periodontal problems. In: Falace DA, ed.
Emergency dental care: diagnosis and management of urgent dental problems. Philadelphia: Lea &
Febiger; 1995. p. 132-50.
16. Aldred MJ, Crawford JM, Cameron AC et al. Dental anomalies. In: Cameron AC, Widmer RP, eds.
17. Karp JM. Delayed tooth emergence. Pediatr Rev 2011;32:e4-17.
18. Vaysse F, Noirrit E, Bailleul-Forestier I et al. [Eruption and teething complications]. Arch Pediatr
2010;17:756-7. [French].
19. Huber KL, Suri L, Taneja P. Eruption disturbances of the maxillary incisors: a literature review. J Clin
Pediatr Dent 2008;32:221-30.
20. Aldred MJ, Cameron AC. Paediatric oral medicine and pathology. In: Cameron AC, Widmer RP, eds.
21. Moos DD, Cuddeford JD. Methemoglobinemia and benzocaine. Gastroenterol Nurs 2007;30:342-5.
22. Government of Canada. Healthy Canadians. Benzocaine sprays with methemoglobinemia. Notice to
hospitals—Health Canada issued important safety information on benzocaine sprays. November 23,
2006. Available from: healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2006/14393a-eng.php.
23. U.S. Food and Drug Administration. FDA Drug Safety Communication: Reports of a rare, but serious
and potentially fatal adverse effect with the use of over-the-counter (OTC) benzocaine gels and liquids
applied to the gums or mouth. April 7, 2011. Available from:
www.fda.gov/Drugs/DrugSafety/ucm250024.htm.
24. Sixou JL, Magaud C, Jolivet-Gougeon A et al. Evaluation of the mandibular third molar pericoronitis
flora and its susceptibility to different antibiotics prescribed in France. J Clin Microbiol 2003;41:5794-
7.
25. Canadian Dental Association. What is pericoronitis and how is it treated? May 27, 2013. Available
from: www.oasisdiscussions.ca/2013/05/27/pc-2/. Accessed December 2015.

Teething Pain
Aphthous Ulcers (Canker Sores)
Adeline T. Chau Markarian, BSc(Pharm), ACPR

Introduction
Aphthous ulcers (aphthous stomatitis, canker sores) and recurrent aphthous ulcers (recurrent aphthous
stomatitis) are an inflammatory and noninfectious oral problem of unknown etiology.1,2 These ulcers are the
most prevalent oral lesions in the general population with a frequency of 5–25% and a 3-month recurrence
rate of 50%.1 The first occurrence is usually between the ages of 10 and 20 years with more than one-third
of school-aged children experiencing these oral lesions.3,4 Aphthous ulcers that start in adult age tend to be
associated with other systemic conditions or tend to have definable predisposing factors.5 With age, the
frequency and severity of aphthous ulcers tend to decrease.5 Women, patients under the age of 40 years,
individuals with a family history of aphthous ulcers and those in middle and upper-middle class
socioeconomic groups have a higher frequency of aphthous ulcers than the general population.5,6,7
Pathophysiology
The etiology of aphthous ulcers is unknown but probably multifactorial with local trauma and stress thought
to be the most likely precipitating factors.1,2,5 Allergies, genetic predisposition, nutritional deficiencies,
preservatives, foods (e.g., chocolate, coffee, peanuts, cereals, almonds, strawberries, cheese, tomatoes and
wheat flour), systemic disease, hormonal changes and some medications (e.g., NSAIDs) may also play a
role.1,2,5,6 Patients with aphthae may have considerable pain which leads to difficulty eating, speaking and
swallowing.1,2,6 Persistent and recurring ulcers can result in weight loss and a decrease in quality of life.1
There are 3 types of aphthous ulcers: minor, major and herpetiform. The most common are minor aphthae,
occurring in 70–87% of cases.1,6
Minor aphthae appear as recurrent, small, round or oval, clearly defined, painful ulcers with shallow necrotic
centres, raised margins and erythematous halos. See Photo, Aphthous Ulcer (Canker Sore). They are usually
smaller than 1 cm in diameter and have a whitish grey pseudomembrane. Lesions may appear as single or
multiple ulcers (1–5 ulcers) usually on movable oral mucosa including the mucosa of the lips and cheeks,
the floor of the mouth, the underside of the tongue and the soft palate.1,6 Minor aphthae heal spontaneously
without scarring within 7–10 days but heal more slowly than other oral wounds.5 A vague localized feeling
of discomfort may precede the actual appearance of the lesion by a few days.6
Photo 1: Aphthous Ulcer (Canker Sore)

Dr. P. Marazi/Science Photo Library
Major aphthae (Sutton's disease or periadenitis mucosa necrotica recurrens) are less common, occurring in
7–20% of affected patients and are more severe than minor aphthae. Although similar in appearance to
minor aphthae, they are larger, exceeding 1 cm in diameter, deeper and appear in larger numbers (1–10
ulcers).1 These aphthae involve the mucosa overlying minor salivary glands and can be found on the lips,
soft palate and throat.5 They often scar and can persist for weeks to months causing significant difficulty
swallowing.1 They are frequently found in patients infected with human immunodeficiency virus (HIV).
Herpetiform aphthous ulcers are the least common, representing 5–10% of cases. They appear as multiple
small clusters of pinpoint ulcers, 2–3 mm in diameter and 10–100 in number but they may coalesce into
widespread, irregular lesions. These ulcers may last 7–30 days and have the potential to scar. Women tend
to be affected more often with herpetiform aphthous ulcers and these ulcers usually have a later age of
onset than minor and major aphthae.6
Goals of Therapy
Infrequent, minor aphthous ulcers:
Control local pain

Reduce duration of ulcers
Restore normal oral function
Ensure adequate food and fluid intake
Decrease frequency and severity of recurrences
Patient Assessment
When evaluating a patient with symptoms suggestive of aphthous ulcers, consider other conditions with
oral ulcerative manifestations. These include infections (viral, treponemal, fungal), autoimmune diseases
(e.g., Behçet's syndrome, inflammatory bowel disease, lupus erythematosus), hematologic diseases (cyclic
neutropenia) and neoplasms (squamous cell carcinoma). Patients with iron or vitamin deficiencies (e.g.,
vitamins B1, B2, B6, B12 or folic acid) or gastrointestinal diseases (e.g., ulcerative colitis, Crohn's disease or
celiac disease) may also present with aphthae-like ulcers.5 Alternative diagnoses to aphthous ulcers include
primary or secondary oral herpes simplex infections, chickenpox, hand-foot-mouth disease and periodic
fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA). Patients with white thickened
patches on the mucosa of the cheeks, gums or tongue may have leukoplakia, a precancerous lesion
associated with the use of tobacco products8 (see Photo, Leukoplakia).
Photo 2: Leukoplakia
Custom Medical Stock Photo/Science Photo Library
Aphthous ulcers normally are not preceded by fever or vesicles and occur almost exclusively on movable
oral mucosa (inside of the cheeks and lips, tongue, floor of mouth and soft palate). When patients present
with a mouth lesion that is not easily distinguished as an aphthous ulcer or have additional symptoms, such
as fever, skin lesions, uveitis, genital ulceration, recurrent bloody or mucous diarrhea, head/neck adenopathy
or malar rash, they may be suffering from some other type of lesion or a systemic disorder and should be
assessed further (Figure 2).2 Figure 1 illustrates the structures of the oral cavity.
Figure 1: Anatomy of the Mouth
Prevention
Several well-recognized factors may contribute to the development and duration of aphthous ulcers.
Local Trauma
If accidental self-biting leads to the development of aphthous ulcers, advise the patient to chew carefully
and slowly, using extra caution or avoiding sharp-edged foods such as hard candy, hard toast, crackers
or potato chips.6 Teeth, dental procedures and devices can also cause trauma and aphthous ulcers.
Patients should consult with their dentist if their teeth or dental appliances have sharp points. Taking
care while brushing teeth gently with a soft toothbrush and the early replacement of toothbrushes to
prevent injury from “splayed” bristles can also help prevent trauma to the oral mucosa.5 Sodium lauryl
sulfate (SLS), commonly found in toothpastes, may interfere with the ulcer healing process and may
worsen pain of existing ulcers.9,10 Patients with SLS-related adverse reactions should use toothpastes
that do not contain this detergent.6,11
Emotional and Environmental Stress
Stress may precede 60% of initial ulcers and may be involved in 21% of recurrent cases.1 Frequency of
aphthous ulcers is 3 times greater in medical and dental students than in the general population.1
Relaxation and imagery training may significantly reduce aphthous ulcers.1
Nutritional Deficiencies
Deficiencies involving iron, zinc, folic acid and vitamins B1, B2, B6 and B12 are more common in patients
with aphthous ulcers than in people without aphthous ulcers.1 Treatment with sublingual
cyanocobalamin 1000 µg daily for 6 months may shorten ulcer episodes, reduce number of ulcers per
month and diminish level of pain even in patients not deficient in vitamin B12.6,12 Vitamin B12 ointment
may also provide some analgesic benefit as adjunctive therapy after 2 days of treatment.13 Calcium and
vitamin C may be deficient in patients with aphthous ulcers. Hematologic screening in children and in
patients with a history of ulcers exceeding 6 months may detect these deficiencies.6,11 Patients with
nutritional deficiencies respond well to replacement therapy.1
Allergies
Oral hypersensitivity reactions to various food additives, essential oils, mints and dental materials and
antibodies to cow's milk and wheat protein have been observed in patients with recurrent aphthous
ulcers (RAU).1 Strict elimination diets involving cow's milk or glutens may resolve or improve RAU.1 If an
allergic or hypersensitivity reaction is suspected, referral to specialist care is warranted.
Drug-related Causes
It has been suggested that patients with RAU have a higher medication intake than those without RAU.14
Medications associated with RAU include ACE inhibitors, antiarrhythmic medications, beta-blockers,
NSAIDs and opioid analgesics.6,14,15 Although the mechanism is not well understood, drug-related
aphthous ulcers usually resolve once the medication is discontinued.15 Smoking appears to offer a
protective effect by producing keratinization of the oral mucosa, although smoking is a risk factor for
other oral lesions including leukoplakia.2,14,15 Nicotine-containing products also tend to decrease the
frequency of RAU.5
Treatment of Underlying Systemic Disease
Identification and treatment of certain systemic diseases have been associated with improvement of
RAU. These systemic conditions include Sweet's syndrome, Crohn's disease, Behçet's disease, various
types of neutropenia, pernicious anemia, systemic lupus erythematosus, HIV infection, PFAPA syndrome
and mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome.5
All patients with aphthous ulcers can benefit from avoiding foods that cause pain. These include foods that
are hard, crusty, sharp, spicy, salty, acidic or difficult to chew, such as crackers, toasted bread, potato chips,
pickles, tomatoes, nuts, citrus fruits and juices. Alcoholic beverages and chocolate may also cause pain and
should be avoided when ulcers are present.6
Patients should address any sources of oral trauma such as ill-fitting dentures, sharp/broken teeth or using
harsh toothpastes containing the detergent sodium lauryl sulfate.
Chemically cauterizing the ulcers with topical compounds (e.g., silver nitrate, hydrogen peroxide) is painful
and should be administered only under specialist care due to the possibility of causing local necrosis and
delaying healing. Cauterization may decrease pain severity after 1 day but has little effect on speed of
healing.2,16,17
Encourage patients to maintain regular daily oral hygiene, which includes twice-daily brushing and flossing
the teeth and a professional dental cleaning at least every 6 months (see Oral Hygiene, Dental Plaque and
Caries).6 Aphthae can be cleansed by rinsing the mouth with salt and water (2.5–5 mL table salt per 250 mL
warm water) several times daily, especially after meals. There is no evidence to suggest that other cleansing
rinses (e.g., sodium perborate or half-strength hydrogen peroxide diluted to 1.5%) provide an advantage over
saline rinses.5
Patients with major or herpetiform aphthous ulcers, RAU or who have severe pain, difficulty eating, drinking,
chewing and swallowing require further evaluation and more extensive drug therapy.
The efficacy of treatment options for aphthous ulcers is mainly anecdotal as few well-designed studies are
available.15 Treatment is therefore empirical and nonspecific and the choice of agent will depend on severity
of pain, number of ulcers, frequency of episodes and patient's tolerance to treatment.15,18
The American Academy of Oral Medicine recommends topical agents as first-line therapy (see Table 3).15
Topical Therapy
Ailments—Mouth Products: Cold Sores and Canker Sores.
Protectants
Placing a mucosal adherent agents such as hydroxypropyl cellulose or carboxymethyl cellulose over
the ulcer may provide temporary pain relief and protection.
Local Anesthetics
Infrequent minor aphthous ulcers resolve on their own and may require only short-term pain
management. Patients seeking temporary pain relief can apply a product containing a topical
anesthetic such as benzocaine or lidocaine.16 The duration of action of topical anesthetics is
relatively short (20–45 minutes) and these agents may be used with oral analgesics and protectants
to provide longer pain relief.
Gels, ointments and pastes can be applied directly to the ulcer using a cotton-tipped swab, such as a
Q-tip, 4 times a day, before meals and at bedtime, for up to 1 week.4 To maximize effectiveness,
remind patients to dry the affected mucosa prior to drug application and avoid eating, drinking and
speaking for 30 minutes after each application.6
Local anesthetics should be used with caution in children under 2 years of age. Increased absorption
of benzocaine in infants and young children has led to methemoglobenemia. The use of excessive
amounts can lead to choking from difficulty swallowing and to being burned from hot food.
Gel formulations have a high alcohol content and may cause an initial stinging or burning on
application which can be distressing to children. Applying ice before using a gel may help prevent this
side effect or another dosage form may be selected.4
For painful ulcers, benzydamine 0.15% topical solution containing ethanol 10% could be used as a
rinse every 3 hours on as-needed basis. The solution should not be swallowed and ingestion of food
or hot liquids while the mouth is numb should be avoided to minimize the risk of burning the mouth
or biting the tongue or cheeks.19
Local Anti-inflammatories
Topical corticosteroids (e.g., clobetasol, fluocinonide, triamcinolone) are useful in relieving pain due
to their anti-inflammatory properties.6 Topical corticosteroids are not effective for preventing ulcer
recurrence or frequency.20 Nevertheless, their efficacy can improve if they are started during the early
phase of ulceration, when lymphocyte activity is at its maximum.
Establishing effective topical delivery of these agents is a problem because they are readily rubbed or
washed away within the mouth. Using the more potent corticosteroids and compounding them with a
mucosal adherent improves delivery. Triamcinolone in Orabase is available commercially and
corticosteroid ointment formulations mix well with equal parts of Orabase, providing better
adherence to the oral mucosa.4 In addition, patients should be advised not to eat or drink for 30
minutes following application. Oropharyngeal candidiasis is a potential side effect and patients
should be monitored for the development of this condition when using topical corticosteroids (see
Oral Candidiasis).6
Dexamethasone ointment can reduce pain and ulcer size when applied to the affected areas 3 times
daily after meals for 5 days. Serum concentration of dexamethasone is not detectable after
applications.21,22 When compared with triamcinolone acetonide in Orabase, dexamethasone
ointment may show faster healing of ulcers with similar speed of pain reduction.23
Local Antibiotics
Tetracycline 5% or minocycline 0.2% mouthwashes may significantly reduce the pain, ulcer size and
duration of RAU as compared with placebo.16,24 The usual dosage is tetracycline 250 mg or
minocycline 10 mg 4 times a day for 10 days, administered as a solution that is retained in the mouth
for 1–2 minutes then expectorated. Tetracycline is chemically unstable in aqueous solution but can
be neutralized with a specific base (see Table 1).16 Using these oral rinses for more than 5 days may
predispose patients to oral fungal infections, skin reactions, sore throat or stained teeth.1,6 Another
concern with frequent or prolonged use is the development of bacterial resistance. Benefits of this
treatment should be weighed against its risks.
Topical application of penicillin G troches (50 mg 4 times daily) may reduce pain as well as lessen
the size, severity, duration and frequency of ulcers.25
Table 1: Preparation and Use of Chemically Stable Tetracycline Suspension

Tetracycline mouthwash 5% (w/v)
Ingredients:
Tetracycline mouthwash 5% (w/v)
Tetracycline hydrochloride 5 g
Methyl-4-hydroxybenzoate 0.1 g
Sodium citrate 6.5 g
Propylene glycol 0.6 g
Sorbitol solution 70% (non-crystallizable) 65.5 g
Tragacanth 0.5 g
Purified water to 118.2 g
Preparation:
1. Dissolve methyl-4-hydroxybenzoate in propylene glycol.

2. Dissolve sodium citrate in purified water.
3. Mix dry tragacanth and tetracycline hydrochloride. Mix equal part of sorbitol solution
and form a gel with the rest of sorbitol solution.
4. Add sodium citrate solution in portions and stir.
5. Add propylene glycol with the dissolved methyl-4-hydroxybenzoate and stir.
Expiration: 6 months
Mode of application: Shake before use. Apply 5 mL of the suspension for 5 min in the mouth
cavity up to 5 times daily and for intensive therapy, the same dose to be used for 10–15 min.
Reproduced with permission from Altenburg A, Zouboulis CC. Current concepts in the treatment of recurrent aphthous stomatitis.
Skin Therapy Lett 2008;13(7):1-4.
Original source: Neues Rezeptur-Formularium for compounded medication: Rezepturhinweise: Tetracyclinhydrochlorid in
zahnärztlichen Anwendungen und Mundspülungen. Govi-Verlag Pharmazeutischer Verlag Eschborn (2005).
Systemic Therapy
All systemic therapies lack convincing efficacy data.26 These agents are not generally recommended or
required but they may be considered for severe cases of major RAU that are unresponsive to all topical
therapies.1,6 With all systemic medications, aphthous ulcers may recur after discontinuation of therapy.
Acetaminophen may be recommended for pain relief using dosages based on the age or weight of the
patient. NSAIDs should be avoided as these agents may cause aphthous ulcers and worsen these
lesions.1,2,5
Colchicine 1–2 mg daily may induce complete remission and reduce the duration and frequency of
ulcers after 3 months of therapy. Symptomatic response may be durable over several years.27
Montelukast 10 mg daily for 1 month followed by alternate day dosing for the second month may reduce
pain, time to healing and number of new aphthous lesions.28
Dapsone can be used for oral and genital aphthous ulcers. It acts as both an antibiotic and an anti-
inflammatory agent. Recommended dose is 100–150 mg daily and can be given with ascorbic acid 500
mg daily to prevent hematologic side effects (hemolysis, methemoglobinemia and agranulocytosis).
Upon discontinuation of treatment, rapid relapse is common.6 In patients with complex aphthosis, weak
evidence suggests that a combination of both colchicine (up to 1.8 mg/day) and dapsone (up to 125–
150 mg/day) may also be effective.29
Pentoxifylline 400 mg 3 times daily may reduce pain severity and size of ulcers.20 This oral anti-TNF
agent has few adverse effects (nausea) and can be used in patients with multiple comorbidities or with
contraindications to more aggressive treatments. However, it should not be used in pregnant women.6
For patients who do not respond to colchicine or pentoxifylline, systemic corticosteroids can be used for
acute exacerbations.16 Prednisolone, or its equivalent, can be given at 10–30 mg daily for up to 1 month
to shorten the ulcer's duration. Longer treatments are not recommended as new lesions cannot be
avoided and long-term adverse effects may occur, such as depression, hyperglycemia, lipodystrophy,
moon facies and osteopenia/osteoporosis.6 Of note, oral corticosteroids are considered safe
medications for pregnant patients.
Weak evidence suggests that the anti-TNF agent infliximab may be an effective treatment option for
patients with severe recurrent oral ulcers who do not respond to other therapies. Infliximab leads to rapid
healing of the lesions within a few days after the first dose with no recurrence for 6–8 weeks.6 The usual
dose is 5 mg/kg body weight at variable frequencies.
Thalidomide is an anti-TNF agent with limited use for this indication due to its severe side effects profile
(neuropathy, abdominal discomfort, fatigue). This agent is used for the treatment of major aphthae in
HIV-positive patients (200 mg/day), but may also be effective for the treatment of major aphthae and
orogenital ulcers (50 mg/day). Thalidomide may induce complete remission as early as 14 days of
starting treatment but causes adverse effects in the majority of patients.18 This agent should not be
used in pregnant women due to its teratogenicity.17
Anecdotal Therapies
Therapies that have been suggested for aphthous ulcers but have received little or no evaluation are listed in
Table 2. Some of these products may interact with other medicines or even cause aphthous ulcers;
therefore, they should be avoided.7
Table 2: Anecdotal Therapies for Aphthous Ulcers (Not Recommended)

2-octyl cyanoacrylate (tissue Levamisole Sucralfate suspension as
adhesive) Licorice, deglycyrrhizinated mouth rinse
Acidophilus L-Lysine Testosterone, subcutaneous
Acyclovir Thiamine
Mixturesa
Agrimony Tormentil
Nicotine patches and
Calendula chewable tablets Vitamin B complex
Caraway Oak bark Vitamin C
Cranesbill Oral contraceptives Witch hazel
Cyclosporine A Prostaglandin E2 gel Zinc lozenges
Echinacea Raw egg
Helium-neon lasers Sage
a
Various combinations, e.g., 1 part prednisolone syrup 15 mg/5 mL or dexamethasone elixir 0.5 mg/5 mL, 2 parts
diphenhydramine elixir 12.5 mg/5 mL, 3 parts doxycycline 25 mg/5 mL or minocycline 50 mg/5 mL, 6 parts lidocaine
2% viscous; used as rinse or applied to ulcer.
Advise patients and monitor for potential side effects and complications of treatment. For example, oral
corticosteroid use can lead to oral candidiasis, and antimetabolites and alkylating agents can cause
hematologic suppression. The patient should monitor ulcer pain daily. Healthcare practitioners should
monitor patients for ulcer pain every 3 days for the first week then 1 week later. If the ulcer worsens or is still
present after 14 days of self-care, patient may require further assessment and treatment. An oral ulcer is
considered chronic if it lasts longer than 2 weeks.30
Resource Tips
Mayo Clinic. Diseases and Conditions. Canker sore. Available from: www.mayoclinic.com/health/canker-
sore/DS00354.
U.S. National Library of Medicine; National Institutes of Health. MedlinePlus. Canker sore. Available from:
www.nlm.nih.gov/medlineplus/ency/article/000998.htm.
Algorithms
Figure 2: Assessment of Patients with Aphthous Ulcers
Drug Table
Table 3: Topical Therapies for Aphthous Ulcers

Drug Dosage
Class:aAnesthetics
Drug/Cost Adverse Effects Comments
benzocaine Apply to Application site May be useful to apply to sores before

Anbesol, affected area burning, edema, eating so mastication could be less
Kank-A, in the mouth erythema, pruritus, painful.
Orajel, others up to QID rash, stinging,
tenderness,
$ urticaria.
Rarely
methemoglobinemia
signs and symptoms
(e.g., respiratory
distress and
cyanosis).
benzydamine Rinse mouth Burning, cough, dry Dose should be held in the mouth for
0.15% with 15 mL mouth, headache, about 30 seconds for best effect.
Pharixia, TID–QID as nausea, numbness,
generics needed; do sedation, stinging,
not swallow vomiting.
$$
lidocaine Apply to Application site May be useful to apply to sores before

Xylocaine affected area burning, edema, eating so mastication could be less
Viscous, in the mouth erythema, pruritus, painful.
generics up to QID rash, stinging,
tenderness,
$ urticaria.
Rarely
methemoglobinemia
signs and symptoms
(e.g., respiratory
distress and
cyanosis).
Drug Class: Anti-inflammatories
triamcinolone Dab on the Local irritation, To avoid a granular gritty sensation do

acetonide ulcers up to sticky or pasty not rub or spread the paste when
Oracort TID sensation in the applying to the lesions. If using
mouth. multiple times daily, it is preferable to
$$ apply after eating.
Drug Class: Protectants
carboxymethyl Use as often Sticky or pasty Coat the involved area of the mouth
cellulose as needed sensation in the with a thin film. Hold in position until it
Orabase particularly mouth. becomes sticky. Do not rub it in.
Paste after eating
a
Legend: $ < $10 $$ $10–20
Suggested Readings
Altenburg A, Zouboulis CC. Current concepts in the treatment of recurrent aphthous stomatitis. Skin Therapy
Lett 2008;13:1-4.
Belenguer-Guallar I, Jiménez-Soriano Y, Claramunt-Lozano A. Treatment of recurrent aphthous stomatitis. A

literature review. J Clin Exp Dent 2014;6:e168-74.
Messadi DV, Younai F. Aphthous ulcers. Dermatol Ther 2010;23:281-90.
References
1. Barrons RW. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst Pharm
2001;58:41-50.
2. McBride DR. Management of aphthous ulcers. Am Fam Physician 2000;62:149-54, 160.
3. Mayo Clinic. Diseases and Conditions. Canker sore. Available from:
www.mayoclinic.com/health/canker-sore/DS00354. Accessed February 25, 2016.
4. Flaitz CM, Baker KA. Treatment approaches to common symptomatic oral lesions in children. Dent
Clin North Am 2000;44:671-96.
5. Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis:
a consensus approach. J Am Dent Assoc 2003;134:200-7.
6. Messadi DV, Younai F. Aphthous ulcers. Dermatol Ther 2010;23:281-90.
7. Sawair FA. Recurent aphthous stomatitis: do we know what patients are using to treat the ulcers? J
Alternat Complement Med 2010;16:651-5.
8. For the dental patient. Common mouth sores and patches. J Am Dent Assoc 2002;133:391.
9. Shim YJ, Choi JH, Ahn HJ et al. Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a
randomized controlled clinical trial. Oral Dis 2012;18:655-60.
10. Healy CM, Paterson M, Joyston-Bechal S et al. The effect of a sodium lauryl sulfate-free dentifrice on
patients with recurrent oral ulceration. Oral Dis 1999;5(1):39-43.
11. Bailey J, McCarthy C, Smith RF et al. Clinical inquiry. What is the most effective way to treat recurrent
canker sores? J Fam Pract 2011;60:621-32.
12. Volkov I, Rudoy I, Freud T et al. Effectiveness of vitamin B12 in treating recurrent aphthous
stomatitis: a randomized, double-blind, placebo-controlled trial. J Am Board Fam Med 2009;22:9-16.
13. Liu HL, Chiu SC. The effectiveness of vitamin B12 for relieving pain in aphthous ulcers: a
randomized, double-blind, placebo-controlled trial. Pain Manag Nurs 2015;16:182-7.
14. Boulinguez S, Reix S, Bedane C et al. Role of drug exposure in aphthous ulcers: a case-control study.
Br J Dermatol 2000;143:1261-5.
15. Femiano F, Lanza A, Buonaiuto C et al. Guidelines for diagnosis and management of aphthous
stomatitis. Pediatr Infect Dis J 2007;26:728-32.
16. Altenburg A, Zouboulis CC. Current concepts in the treatment of recurrent aphthous stomatitis. Skin
Therapy Lett 2008;13:1-4.
17. Altenburg A, El-Haj N, Micheli C et al The treatment of chronic recurrent oral aphthous ulcers. Dtsch
Arztebl Int 2014;111:665-73.
18. Chattopadhyay A, Shetty KV. Recurrent aphthous stomatitis. Otolaryngol Clin North Am 2011;44:79-
88.
19. Lalla RV, Schubert MM, Bensadoun RJ et al. Anti-inflammatory agents in the management of
alimentary mucositis. Support Care Cancer 2006;14:558-65.
20. Bruce A, Rogers RS. New and old therapeutics for oral ulcerations. Arch Dermatol 2007;143:519-23.
21. Belenguer-Guallar I, Jiménez-Soriano Y, Claramunt-Lozano A. Treatment of recurrent aphthous
stomatitis. A literature review. J Clin Exp Dent 2014;6:e168-74.
22. Liu C, Zhou Z, Liu G et al. Efficacy and safety of dexamethasone ointment on recurrent aphthous
ulceration. Am J Med 2012;125:292-301.
23. Al-Na'mah ZM, Carson R, Thanoon IA. Dexamucobase: a novel treatment for oral aphthous
ulceration. Quintessence Int 2009;40:399-404.
24. Gorsky M, Epstein J, Rabenstein S et al. Topical minocycline and tetracycline rinses in treatment of
recurrent aphthous stomatitis: a randomized cross-over study. Dermatol Online J 2007;13(2):1.
25. Zhou Y, Chen Q, Meng W et al. Evaluation of penicillin G potassium troches in the treatment of minor
recurrent aphthous ulceration in a Chinese cohort: a randomized, double-blinded, placebo and no-
treatment-controlled, multicenter clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2010;109(4):561-6.
26. Brocklehurst P, Tickle M, Glenny AM et al. Systemic interventions for recurrent aphthous stomatitis
(mouth ulcers). Cochrane Database Syst Rev 2012;9:CD005411.
27. Fontes V, Machet L, Huttenberger B et al. [Recurrent aphthous stomatitis: treatment with colchicine.
An open trial of 54 cases]. Ann Dermatol Venereol 2002;129:1365-9. [French].
28. http://www.ncbi.nlm.nih.gov/pubmed/19926502Femiano F, Buonaiuto C, Gombos F et al. Pilot study
on recurrent aphthous stomatitis (RAS): a randomized placebo-controlled trial for the comparative
therapeutic effects of systemic prednisone and systemic montelukast in subjects unresponsive to
topical therapy. Oral Surg Med Oral Pathol Oral Radiol Endod 2010;109:402-7.
29. Lynde CB, Bruce AJ, Rogers RS. Successful treatment of complex aphthosis with colchicine and
dapsone. Arch Dermatol 2009;145:273-6.
30. Munoz-Corcuera M, Esparza-Gomez G, Gonzales-Moles MA et al. Oral ulcers: clinical aspects. A tool
for dermatologists. Part I. Acute ulcers. Clin Exp Dermatol 2009;34:289-94.

Canker Sores
Canker Sores—What You Need to Know
To help your canker sore feel better:
Avoid foods that hurt—foods that are hard, crusty, sharp, spicy, salty, acidic or hard to chew, e.g., crackers,
potato chips, pickles, oranges, lemons, tomatoes and fruit juices.
Take care to keep your teeth and gums clean but be careful not to hurt the canker sore. Brush your teeth using a
soft toothbrush twice a day and use dental floss once a day. Use a new soft toothbrush if your old one has
bristles that are spread apart or broken, which can hurt your mouth or the canker sore.
Rinse your mouth with 1/2–1 teaspoonful (2.5–5 mL) of table salt dissolved in 1 cup of warm water several
times a day to help soothe the canker sore. Use this rinse after meals to remove bits of food that may bother
the canker sore. Be sure to spit out the salt water after rinsing.
Most mouthwashes for bad breath have a high alcohol content and using them will make the canker sore sting.
Don't use these mouthwashes when you have a canker sore.
A canker sore should get better on its own in 10–14 days. Your pharmacist may suggest you use an ointment
with an anesthetic in it to help the pain for a short time. You may use this 4 times a day for no longer than 14
days. Put a small amount of anesthetic ointment on the canker sore, using a cotton-tipped swab (Q-tips), before
eating meals and before going to bed.
Your pharmacist may suggest that you cover the canker sore with a small amount of Orabase or Zilactin to help
lessen the pain.
You may use a nonprescription pain medicine such as acetaminophen to help reduce the pain. Your pharmacist
can help you choose a pain medicine that is right for you and tell you how to take it.
To help prevent canker sores:
If you sometimes bite the inside of your cheek and a canker sore appears at that spot, take extra care while
chewing. Chew your food slowly and try not to talk while you are chewing.
If you have any teeth or dental work with sharp points, see your dentist so that the sharp points can be made
less irritating.
Most toothpastes have an ingredient called sodium lauryl sulfate. Some people have fewer canker sores when
they use a toothpaste that does not have this ingredient in it. Your pharmacist can suggest a toothpaste if you
want to try this approach.
You should see a doctor or dentist if:
The canker sore is still there after 14 days.

The canker sore has gotten larger or if more canker sores have developed.
The pain is not controlled when using the medication recommended, and you have difficulty chewing or
swallowing.
You also feel sick, have a fever, pain in the joints, irritated eyes or many watery bowel movements.
Cold Sores (Herpes Labialis)
James S. Conklin, BSc(Pharm), ACPR

Pathophysiology
Two herpes simplex viruses (HSV) are most relevant to cold sores: herpes simplex-1 (HSV-1) and herpes
simplex-2 (HSV-2). HSV-1, which is most commonly transmitted via saliva, causes the majority of oral
herpes infections; HSV-2, which is present in genital secretions, causes the majority of genital herpes
infections.1,2 However, orogenital contact may cause a primary infection of either type in either the oral or
genital region.1,2 Both HSV-1 and HSV-2 can cause primary or recurrent infections. When symptomatic, and
involving the oral region, a first infection is known as primary herpes gingivostomatitis. Although not
inevitable, 20–40% of patients who experience a primary herpes infection develop subsequent recurrent
herpes infections caused by reactivation of HSV that remains latent in neural ganglion cells.1,2 Recurrences
in the oral region most commonly affect the vermilion border of the lips and are known as herpes labialis,
cold sores or fever blisters2,3 (see Photo, Cold Sore). Less commonly, recurrences appear on the palate, chin
or oral mucosa.2
Photo 1: Cold Sore
Primary HSV-1 infection occurs in approximately one-third of school-aged children4 and serological evidence
of HSV-1 infection is evident in up to 80% of adolescents and adults.1,2 Babies generally acquire anti-HSV
antibodies from their mothers, which protect them from infection until around 6 months of age.3
The incidence of infection with HSV-2 increases after sexual activity begins, with risk factors including being
female, a history of sexually transmitted disease and multiple sexual partners.3,5,6
Goals of Therapy
Reduce any discomfort, including pain or itching
Reduce viral shedding
Reduce the duration of lesions
Reduce the severity of the episode
Prevent secondary bacterial infection
Prevent recurrences
Patient Assessment
Primary HSV infections are frequently subclinical, or cause symptoms difficult to differentiate from upper
respiratory tract infections.2,7,8 Symptomatic infections may be characterized by malaise, fever, chills,
muscle aches, lymphadenopathy and multiple crops of painful vesicles or blisters and ulcerative erosions on
the tongue, palate, gingiva, buccal mucosa and lips, occurring 1–26 days after inoculation.1,2 The lesions
rupture readily, leaving small ulcers covered with a pseudomembrane and surrounded by erythema.5 This
primary infection lasts 1–3 weeks without scarring.6 Constitutional symptoms may last 10–14 days.2 Oral
shedding of the virus may continue up to 23 days.6 In severe primary episodes, discomfort may interfere
with eating and drinking to the point of dehydration.2 Some patients go on to have recurrent infections,
typically 1–6 episodes per year, while others never experience a second episode.2 A first episode in a patient
already seropositive for HSV is termed a nonprimary initial infection, and these infections tend to be less
severe.2
A prodromal tingling, itching or burning sensation in the location of the eruption may occur 2–24 hours
before the appearance of the vesicles in 60% of patients.2,5,6 The lesion then appears over 1–2 days.6
Papules on an erythematous base usually become vesicles within hours and then break open, leaking a
clear, sticky fluid, and subsequently progress through the stages of ulceration, crusting, and healing over
72–120 hours.2,6 Time to full healing without scarring may take up to 7–10 days.5,6 Generally there are no
systemic symptoms and patients complain only of the unsightly appearance and pain, and sometimes
itching. In a quarter of recurrent cases, the infection heals before blisters or ulcers can form.1
Patients who are immunosuppressed by disease or drug therapy are at higher risk of recurrences of HSV.
This includes those receiving immunosuppressive cancer chemotherapy or drugs to suppress rejection of
organ transplantation, and those with acquired immunodeficiency syndrome (AIDS). Atopic individuals may
develop a rapidly progressing HSV cutaneous infection.
Refer immunocompromised patients or those with frequent, persistent, recurrent or swollen oral lesions to
an appropriate healthcare practitioner for assessment (Figure 1).
Prevention
Common stressors that can precipitate recurrences include emotional stress, dental extraction, fever,
hormonal factors, hyperthermia, menstruation, physical trauma or surgery, sun exposure (UV light) and
upper respiratory infection.1,2,5,9
Prophylactic treatment prior to dental procedures may be indicated to prevent a recurrence.10
Protecting affected areas from sun exposure, especially while at the beach and on ski hills, will likely reduce
the frequency of cold sore recurrences.6,7,11 A sunscreen with an SPF of 30 or higher should be applied to
the lips and face 30 minutes prior to exposure.
Reducing stress (e.g., eating well, getting enough sleep and exercise, relaxation) may also help prevent
recurrences in individuals for whom stress is a known trigger.5,7
Avoid spread of cold sores to other parts of the body and to other people by frequent hand washing and
avoiding skin-to-skin contact with others until after the blister has dried up and crusted over.
Advise patients to keep the lesion clean with gentle washing using a mild soap and water. This can also be
accomplished by soaking the area with cool, tap-water compresses.12 Patients should avoid excessive
touching of the lesion and should wash their hands frequently to prevent autoinnoculation and spread of
HSV.
Heat application is a treatment yet to be evaluated through randomized research. Devices in the shape of a
lipstick have been marketed for use on areas where prodromal symptoms are felt. It is postulated that the
high temperature (50 degrees Celsius) blocks replication of the virus and the resultant formation of
blisters.1 More evidence is required before such devices could be recommended for the treatment of cold
sores.
Although oral HSV infections in immunocompetent patients are self-limiting, antivirals and analgesics can
be recommended for primary or recurrent infections. Topical protectants are also available to help prevent
cracking and excessive drying of the HSV lesions (e.g., allantoin, calamine, cocoa butter, petrolatum, zinc
oxide).13 Table 1 presents nonprescription medications commonly used to manage cold sores. For further
discussion of pharmacologic therapy for cold sores, consult the Compendium of Therapeutic Choices:
For comparative ingredients of nonprescription products, consult the Compendium of Products of Minor
Ailments—Analgesic Products: Internal Analgesics and Antipyretics; Mouth Products: Cold Sores and Canker
Sores; Skin Care Products: Anesthetics, First Aid.
Analgesics
Systemic analgesics such as acetaminophen, ibuprofen or naproxen can be recommended to control

moderate to severe pain for a period not exceeding 3 days. Topical products containing anesthetics such
as benzocaine, camphor, lidocaine, menthol, phenol, pramoxine, or prilocaine may be useful in relieving
mild pain for a relatively short period of time. See Table 1 for commonly used doses.
Antivirals
The topical antiviral docosanol prevents the herpes simplex virus from spreading to healthy cells.
Without treatment, the accepted natural healing time of cold sores is 7–10 days. A pivotal efficacy trial
of docosanol vs. placebo (polyethylene glycol) found a reduced time to healing of 4.1 days vs. 4.8 days
(-17 hours) and a reduced time to cessation of pain of 2.2 vs. 2.7 days (-12 hours) when the creams were
applied 5 times daily, with the first applications within 12 hours of episode onset.17 [Evidence: SORT B]
Because the time to healing in the placebo group was also significantly lower than natural healing time,
the issue of a potential therapeutic effect of the polyethylene glycol vehicle has been raised.18
Docosanol is a safe and effective topical treatment of cold sore lesions and should be applied 5 times
daily at the first sign of pain, itching, burning, redness or tingling.
Several other antiviral agents including acyclovir, famciclovir and valacyclovir have been studied for
either the treatment or prophylaxis of cold sores. Not all of these drugs have an official indication for
cold sores in the general population. Valacyclovir and famciclovir (prodrugs of acyclovir and penciclovir,
respectively) are designed to increase the bioavailability of their active forms.2 Generally speaking, these
antiviral agents have few toxic effects because they are converted by viral thymidine kinase to active
drug only once they are inside virally infected cells.2
Three differing approaches to antiviral treatment may be used: intermittent episodic therapy (IET),
chronic suppressive therapy (CST) or intermittent suppressive therapy (IST).2
IET is the treatment of isolated, acute episodes of HSV at the first clinical sign or symptom. For initial
primary infections, evidence supports the use of acyclovir, valacyclovir and famciclovir.19,20,21,22,23
Prompt initiation of treatment is more efficacious, but does not decrease recurrences.2 IET for recurrent
infections is effective if begun within 48 hours of an outbreak.2 Evidence supports the use of oral
acyclovir, valacyclovir, famciclovir and acyclovir 5% cream with or without topical
hydrocortisone.24,25,26,27,28,29,30 Overall, topical treatments appear to be less effective than systemic
treatments.2
CST is not indicated for most patients with HSV infection, but may be appropriate for the 5–10% of
patients who experience frequent recurrences (≥6 per year), who also experience disfigurement, difficulty
swallowing or severe pain, have prolonged episodes, or are particularly distressed.2 Evidence supports
the use of oral acyclovir and valacyclovir.23,25,31,32
IST is appropriate when recurrences can be anticipated based on known precipitating factors (see
Prevention), particularly in situations where decreasing viral shedding will decrease the likelihood of
infecting seronegative individuals.2 Specific dosing guidelines are not available for IST, but extrapolation
of data from CST studies is thought to be appropriate.2 Oral acyclovir has been shown to have some
effect on preventing sunlight-induced recurrences but data for topical acyclovir cream are conflicting
(possibly due to poor penetration from site of application).33,34,35,36
Corticosteroids
Corticosteroids are not routinely recommended for use in oral inflammation caused by viruses, as they
may mask the spread of infection and suppress the normal immune response. However, their topical use
(e.g., fluocinonide 0.05%, hydrocortisone 1%) in conjunction with antivirals may be helpful.37
There is some evidence that a cream of lemon balm (Melissa officinalis) containing 1% of a 70:1 leaf
extract, applied to the site of a cold sore during the prodromal stage, reduces the number and size of
lesions, although the overall severity of the outbreak is not lessened.38,39 Lemon balm is usually applied
2–4 times daily from first sign of prodrome to a few days after the lesions have healed.38,39,40
Lysine, one of the essential amino acids, is marketed in oral and topical dosage forms for prevention and
treatment of cold sores. Evidence regarding the effectiveness of lysine for this indication varies. Some
studies suggest its efficacy in prevention is dose dependent. Studies using lower dosages (e.g., 624 mg
daily) did not show benefit whereas 6 of 7 studies using doses ranging from 750–4000 mg daily support
its use to decrease the frequency of recurrences, and to reduce the severity and time to healing.8,41,42
Large amounts of nitrogen are produced through the metabolism of lysine. Persons with renal or hepatic
disease may have difficulty eliminating this nitrogen and therefore its use as a supplement is
contraindicated in these patients. Lysine can increase the absorption and decrease the elimination of
calcium.41,42 Topical application of lysine in a combination product also containing zinc oxide and 14
other ingredients seemed to decrease symptoms and duration of cold sores when applied every 2
hours.43
Other Therapies
Limited evidence from a single small study suggests that zinc sulfate 22.5 mg twice daily for 4 months
may reduce the occurrence of cold sores as well as the duration of lesions during an episode.8
There is no published evidence regarding the safety and effectiveness of heparin in the treatment of cold
sores, although it is an ingredient in frequently recommended products.
Caustic substances such as silver nitrate may create further damage and should not be applied to cold
sores.
Highly astringent topical ingredients such as tannic acid are not recommended for treatment of cold
sores. They have the potential to cause excessive drying of the area with resultant fissuring, discomfort
and potential bacterial superinfection.12,13 In addition, the herpes virus may be fractionated by
astringents thereby causing resistant strains to emerge.13
Cold sores are expected to resolve within 2 weeks. If nonpharmacologic and pharmacologic treatments do
not relieve the discomfort, the lesions spread, or the patient develops symptoms of systemic illness (e.g.,
fever, malaise, swollen glands), further evaluation is indicated. If application of a product containing a local
anesthetic causes increased erythema and edema in the area of the lesion, contact dermatitis should be
suspected and the product discontinued.
Resource Tips
Herpes-Coldsores (HC) Support Network. Herpes-coldsores. Available from: www.herpes-coldsores.com.
MayoClinic. Diseases and Conditions. Cold sore. Available from: www.mayoclinic.org/diseases-

conditions/cold-sore/basics/definition/con-20021310.
MedicineNet. Cold sores (non-genital herpes simplex infections). Available from:

www.medicinenet.com/herpes_simplex_infections_non-genital/article.htm.
U.S. Centers for Disease Control and Prevention. Available from: www.cdc.gov.
Algorithms
Figure 1: Assessment of Patients with Cold Sores

Drug Table
Table 1: Nonprescription Drug Therapy For Cold Soresa
Drug/Costb Dosage Adverse Drug Comments

Drug Class: Analgesics, Oral

acetaminophen Adults and Nausea, rash; Increased risk of Should not be

Atasol Preparations, children >12 chronic use of hepatotoxicity used for >3
Tempra, Tylenol, y: 10–15 high doses may with excessive days.
generics mg/kg Q4– produce alcohol intake (>3 Intended for
6H po, not to significant liver drinks/day). pain relief.
$ exceed 4000 and renal Acetaminophen
mg/24 h toxicity. may increase INR
Children <12 in warfarin-treated
y: 10–15 patients; check
mg/kg Q4– INR if
6H po/pr as acetaminophen
needed for dose exceeds 2
symptom g/day for ≥3
management; consecutive days.
maximum 75 Adjust warfarin
mg/kg/day. dosage as
Do not required.
exceed adult
dose
ibuprofen All age Dizziness, Increased risk of Should not be

Advil, Advil Liquid Gels, groups: 5–10 headache, bleeding with used for >3
Motrin, generics mg/kg Q6– lightheadedness, anticoagulants days.
8H po, not to dyspepsia, (e.g., warfarin) or Intended for
$ exceed 3 nausea, antiplatelet drugs pain relief.
doses/day heartburn, (e.g., clopidogrel).
Maximum abdominal pain. May decrease
dose for self- effect of
care: 1200 antihypertensives.
mg/day May decrease
renal clearance of
lithium; monitor
lithium levels.
Increased risk of
GI bleeding when
used with SSRIs
or corticosteroids.
naproxen sodium Adults and Dizziness, Increased risk of Should not be

Aleve, generics children >12 headache, bleeding with used for >3
y: 220 mg lightheadedness, anticoagulants days.
$ Q8–12H po, dyspepsia, (e.g., warfarin) or Intended for
not to exceed nausea, antiplatelet drugs pain relief.
440 mg/day heartburn, (e.g., clopidogrel).
abdominal pain. May decrease
effect of
antihypertensives.
May decrease
renal clearance of
lithium; monitor
lithium levels.
Increased risk of
GI bleeding when
used with SSRIs
or corticosteroids.
Drug Class: Analgesics, Topical
benzocaine Adults and Application site No significant May offer

Anbesol, Orajel, others children >2 y: numbness and drug interactions. temporary relief
Apply to tingling. Allergic of pain and
$$ affected area contact itching. More
for 1–5 h dermatitis. likely to cause
then remove sensitization
than lidocaine.
Available as
liquid, gel or
cream in
various
strengths.
camphor/menthol/phenol Adults and Mild tingling, No significant Offer temporary

Blistex, Blistex Lip children >2 y: cool feeling. drug interactions. relief of pain
Medex, others Apply to May leave a and itching
affected area white residue on associated with
$ 3–4 times skin. cold sores.
daily Camphor at a
concentration
>3% and
menthol >1%
can cause
irritation and
inflammation
and are
therefore
contraindicated
in treatment of
cold sores.
lidocaine Adults and Application site No significant May offer

Maxilene, generics children >2 y: numbness and drug interactions. temporary relief
Apply to tingling. Allergic of pain and
$$ affected area contact itching. May be
for 1–5 h dermatitis. less sensitizing
then remove than
benzocaine.
Available as
liquid, gel or
cream in
various
strengths.
lidocaine/prilocaine 2.5% Adults and Application site No significant Application

EMLA Cream children >2 y: numbness and drug interactions. times longer
Apply to tingling. Allergic than 5 h have
$$ affected area contact no added
for 1–5 h dermatitis. benefit since
then remove the analgesic
effectiveness
dissipates over
time.
May reduce the
duration of
symptoms and
the duration of
eruptions by
about half.14,15
May offer
temporary relief
of pain and
itching.
pramoxine Adults and Burning or No significant Local

Gold Bond Medicated children >2 y: stinging at site drug interactions. anesthetics
Anti-Itch, Polysporin Itch Apply to of application. with a non-
Relief, others affected area ester, non-
for 1–5 h amide structure
$$ then remove (e.g.,
pramoxine) are
thought to be
the least
sensitizing.14,15
Cross-
sensitization
with other local
anesthetics is
unlikely.
Drug Class: Antivirals, Topical

docosanol 10% Adults and Mild and No significant Inhibits fusion

Abreva children >12 infrequent drug interactions. between the
y: Apply to stinging plasma
$$$ the affected sensation. membrane and
area at the the herpesvirus
first sign of envelope
pain, itching, leading to
burning, blocking viral
redness or entry into the
tingling every cell.16,17
3 h for 5–10 Most effective
days if used early in
the course of
an outbreak
before a large
number of host
cells are
infected. May
decrease
duration of
painful
symptoms and
time to healing
by 17–79
h.16,17
a
For more information on antiviral therapy for HSV infection, consult the Compendium of Therapeutic Choices:
b
Cost of smallest available pack size or 3-day supply; includes drug cost only.
Legend: $ < $5 $$ $5–10 $$$ $10–15
Suggested Readings
Cernik C, Gallina K, Brodell RT. The treatment of herpes simplex infections: an evidence-based review. Arch
Intern Med 2008;168:1137-44.
Cunningham A, Griffiths P, Leone P et al. Current management and recommendations for access to antiviral
therapy of herpes labialis. J Clin Virol 2012;53:6-11.
Drugge JM, Allen PJ. A nurse practitioner's guide to the management of herpes simplex virus-1 in children.
Pediatr Nurs 2008;34:310-8.
Gilbert SC. Management and prevention of recurrent herpes labialis in immunocompetent patients. Herpes
2007;14:56-61.
Opstelten W, Neven AK, Eekhof J. Treatment and prevention of herpes labialis. Can Fam Physician
2008;54:1683-7.
References
1. Opstelten W, Neven AK, Eekhof J. Treatment and prevention of herpes labialis. Can Fam Physician
2008;54:1683-7.
Mouth Products: Cold Sores and Canker Sores
Product Manufacturer Dosage Anesthetic Other Active Ingredients

Form
Abreva GlaxoSmithKline gel docosanol 10%
Consumer
Healthcare
Anbesol Gel Paladin gel benzocaine

10%
Anbesol Gel Extra Paladin gel benzocaine

Strength 20%
Anbesol Liquid Paladin liquid benzocaine

Extra Strength 20%
Blistex DCT Blistex ointment camphor 0.38%

menthol 0.6%
octinoxate 7.3%
oxybenzone 4.5%
phenol 0.48%
Blistex Five Star Blistex ointment homosalate 9.6%

Lip Protection octinoxate 7.5%
octisalate 5%
oxybenzone 5%
petrolatum 30.1%
Blistex Fruit Blistex stick dimethicone 2%

Smoothies Lip octinoxate 7.5%
Balm
oxybenzone 2.5%
Blistex Lip Balm Blistex ointment dimethicone 2%

Regular/Berry/Mint oxybenzone 2.5%
padimate O 6.6%
Blistex Lip Medex Blistex ointment camphor 1%

menthol 1%
phenol 0.54%
Form
Blistex Medicated Blistex ointment camphor 0.38%
Lip Conditioner menthol 0.6%
SPF 15
meradimate 2.5%
padimate O 6.6%
phenol 0.45%
Blistex Medicated Blistex ointment camphor 0.5%

Lip Ointment phenol 0.5%
menthol 0.6%
dimethicone 1.1%
Blistex Moisture Blistex ointment octinoxate 7.5%

Melt oxybenzone 2.5%
petrolatum 31.7%
Blistex Silk & Shine Blistex stick dimethicone 2%

Lip Balm octinoxate 7.5%
oxybenzone 2.5%
Canker Care+ Quantum Health gel menthol 0.5%
Canker Cover Quantum Health patch menthol 2.5 mg

Patch
Canker-Xa Sunstar GUM gel aloe vera

polyvinyl pyrrolidone (PVP)
sodium hyaluronate
Cold Sore Lotion Rougier liquid benzoin 10%

camphor 4%
menthol 2%
Coldsore-FX Valeant ointment propolis 30 mg
Dynamiclear Rapid Paladin gel calendula officinalis 0.5 mg

sulfate 40 mg
hypericum perforatum 0.5 mg
Kank-A Blistex liquid benzocaine cetylpyridinium chloride 0.1%

20%
L-Lysine 500 mg various capsule lysine hydrochloride 500 mg
L-Lysine 1000 mg various tablet lysine 1000 mg

Form
Lipactin GlaxoSmithKline gel heparin sodium 160 IU/g
Consumer zinc sulfate 5 mg
Healthcare
Lipclear Cold Sore Quantum Health patch N/Ab

Patch
Patch uses hydrocolloid technology
to aid healing
Lipclear Lysine Quantum Health ointment lysine 1.6%

Plus Ointment zinc oxide 1.2%
Lypsyl Extreme Lornamead stick camphor 0.53%

Cold Sore Relief menthol 0.7%
Orabase Paste ConvaTec paste gelatin 13.3%

pectin 13.3%
sodium carboxymethyl cellulose
13.3%
Orajel Dual Action Church & gel benzocaine menthol 2%

Gel Dwight 15%
Orajel Maximum Church & gel benzocaine

Strength Dwight 20%
Orajel Maximum Church & liquid benzocaine

Strength Liquid Dwight 20%
Orajel Maximum Church & paste benzocaine

Strength PM Dwight 20%
Orajel Maximum Church & swab benzocaine

Strength Swabs Dwight 20%
Orajel Mouth Sore Church & gel benzocaine zinc chloride 0.1%
Gel Dwight 20%
Orajel Regular Church & gel benzocaine

Strength Dwight 10%
Orajel Ultra Canker Church & gel benzocaine menthol 2%

Sore Gel Dwight 15%
OralMedic Barrier Epien Medical swabstick HybenX (a mixture of

Solution hydroxybenzenesulfonic acid,
hydroxymethylbenzenesulfonic
acid, sulfuric acid and water)
Form
Peroxyl Mouth Colgate liquid hydrogen peroxide 2%
Sore Rinse
Polysporin Lip Johnson & ointment camphor 1.5%

Therapy Johnson menthol 0.75%
phenol 0.5%
Polysporin Cold Johnson & patch N/Ab

Sore Patch Johnson
Patch uses hydrocolloid technology
to aid healing
Zilactin-B Blairex gel benzocaine

10%
Zilactin Cold Sore Blairex gel benzyl alcohol 10%

Gel
a Ingredient strengths not available.

b N/A = Not applicable.
Dry Mouth
Victoria Kletas, BScPharm, MSc

Pathophysiology
Dry mouth, also known as xerostomia, is a common symptom usually associated with salivary hypofunction resulting in reduced
quantity or altered quality of saliva. It has been estimated that a 50 percent reduction in salivary secretion needs to occur before
xerostomia becomes apparent.1 However, xerostomia and hyposalivation are not synonymous since xerostomia (a subjective
feeling) may exist in the presence of normal salivary flow (an objective measure) and some patients may not complain of
xerostomia even in the presence of demonstrated hyposalivation. Xerostomia affects about one in every 4–5 adults. It can occur
at any age but is more prevalent in older individuals, affecting 25% of women and 16% of men.2 Rates in institutionalized elderly
people may be as high as 50%.3
Xerostomia is not a disease, but a manifestation secondary to a medical condition, a drug or radiation to the salivary glands
(head and neck area) in cancer patients.4 Following radiation therapy, the degree of permanent xerostomia depends on the
volume of salivary gland included in the fields of radiation and the total radiation dose. Radiation causes a change to secretory
cells resulting in a reduction of salivary output and increased viscosity of the saliva.5
Xerostomia can be a component of graft-versus-host disease following bone marrow transplantation.2,6 Mouth breathing due to
dyspnea, nasal obstruction or delivery of oxygen via nasal prongs can be a major cause of dry mouth in the terminally ill.7
Individuals infected with HIV may sometimes experience salivary and parotid gland enlargement leading to xerostomia.4 The
risk of dry mouth is also increased by smoking or chewing tobacco and the intake of caffeine-containing beverages.8 Patients
undergoing hemodialysis or with poorly controlled diabetes may also be at risk of xerostomia.9,10
Sjögren's syndrome, a chronic inflammatory autoimmune disease, is a common cause of dry mouth.11 It is characterized by
lymphocytic infiltration of salivary and lacrimal glands and, in addition to xerostomia, results in blurred vision, decreased
lacrimal function, recurrent eye and mouth infections, difficulty swallowing, dry nasal passages, dry throat, and smell and taste
alterations.11,12 Other systemic diseases that can cause xerostomia are listed in Table 1.
Table 1: Systemic Conditions that can Cause or are Associated with Dry Mouth
Autoimmune diseases Neurologic disorders Miscellaneous
Celiac disease Bell's palsy Absent or malformed salivary glands
Rheumatoid arthritis Parkinson's disease Alcoholic cirrhosis
Scleroderma Psychiatric disorders Bone marrow transplantation
Sjögren's syndrome Alzheimer's disease Dehydration
Systemic lupus erythematosus Anxiety Hypertension
Endocrine disorders Depression Nephritis
Addison's disease Viral infections Nutritional deficiencies
Diabetes mellitus Hepatitis C Primary biliary cirrhosis
Hyperlipidemia HIV infection
Hypothyroidism Mumps
Genetic diseases
Cystic fibrosis
Down syndrome
Saliva has various protective functions which include maintaining the neutral pH of the mouth, promoting remineralization of
teeth, coating the teeth and lubricating the oral mucosa, providing local antimicrobial activity and assisting in the taste
mechanism.6 The loss of saliva's protective functions can affect all of the mouth's functions and may increase the risk of
developing Candida infection and dental caries.13 It can also lead to a lack of efficacy of certain medications (e.g., sublingual
nitroglycerin or lorazepam). Table 2 lists potential complications of dry mouth that may affect a person's general well-being and
quality of life.2
Table 2: Potential Complications of Dry Mouth

Avoidance of some foods that are difficult to chew and swallow Inhibition of taste sensation
Decreased ability to chew and swallow Oral infections, e.g., candidiasis, gingivitis
Decreased nutritional status Tooth loss
Impaired ability or willingness to talk Wearing dentures becomes uncomfortable or
Increased dental caries impossible
Consider xerostomia if a patient is having difficulty eating dry foods such as crackers,4 or if lipstick adheres to the front teeth in
women.14 On examination, the mucosa may be dry and sticky, with the saliva appearing stringy or foamy. Dental caries may be
found at the cervical margin (neck of teeth) or incisal margins (the tips) of the teeth.4 The mucosa may appear erythematous
due to overgrowth of Candida albicans, with patches commonly affecting the hard or soft palate and dorsal surface of the
tongue.
Goals of Therapy
Prevent complications of dry mouth such as dental caries, poor nutrition, fungal infection
Relieve symptoms and improve mouth comfort
Patient Assessment
Help patients evaluate their condition by referring to Figure 1. Patients may have differing perceptions of whether or not their
mouths are dry. Some have sufficient saliva flow, but complain of dry mouth. Others have true xerostomia, yet do not recognize
that their mouths are dry. Encourage patients to conduct a daily mouth examination and check for any red or white patches,
ulcers or tooth decay. If anything unusual is found, or if patients are complaining of dry mouth, further assessment is warranted
to find the underlying cause.
Difficulty eating (e.g., mouth feels dry while eating, patient has difficulty swallowing food and needs to sip water to swallow dry
food), is suggestive of salivary hypofunction as the cause of dry mouth.6 The continuous presence of dry mouth symptoms
during the day is associated with more significant salivary hypofunction than if there is gradual onset of symptoms over the
course of the day. Symptoms of dry mouth that occur only at night are usually not associated with salivary hypofunction
because salivary function normally approaches zero during sleep.6 Sleep apnea, nasal congestion and breathing through one's
mouth may cause exacerbation of nighttime symptoms of dry mouth.
Patients may experience regional or generalized mucosal pain, often described as “burning,” or they may describe the inability to
eat acidic or spicy foods, leading them to make changes in their diet.6 This can be suggestive of chronic atrophic candidiasis,
secondary to dry mouth. Patients with chronic atrophic candidiasis frequently also have angular cheilitis, seen as “cracks” in the
corners of the mouth. Such patients require formal diagnosis and treatment and appropriate referral is recommended (see Oral
Candidiasis).
One of the more common causes of xerostomia (especially in the elderly) is medications. Many classes of drugs can cause dry
mouth including adrenergic agonists, anticholinergics, antidepressants, antiemetics, antihistamines, antiparkinson agents,
antipsychotics, benzodiazepines, decongestants, opioids and urinary antispasmodics.15,16,17 The drug effects on quantity and
quality of saliva are generally not permanent. Drugs that cause significant dry mouth in more than 10% of patients are listed in
Table 3.17,18
Table 3: Drugs Causing Significant Dry Mouth in >10% of Patients

Adrenergic agonists nortriptyline Benzodiazepines
isoproterenol paroxetine alprazolam
pseudoephedrine phenelzine chlordiazepoxide
Alpha-adrenergic receptor agonists trimipramine clonazepam
clonidine venlafaxine clorazepate
Antiarrhythmics Antiemetics diazepam
propafenone nabilone flurazepam
Anticholinergics prochlorperazine lorazepam
atropine sulfate Antihistamines oxazepam
belladonna chlorpheniramine temazepam
benztropine mesylate diphenhydramine Biologic response modulators
glycopyrrolate Antiparkinson agents interferon alfa-2a
ipratropium bromide selegiline interferon alfa-2b
scopolamine trihexyphenidyl Ergot alkaloids
Antidepressants Antipsychotics ergotamine
amitriptyline loxapine NSAIDs
amoxapine olanzapine Opioid analgesics
bupropion Antispasmodics Retinoic acid derivatives
clomipramine dicyclomine isotretinoin
desipramine flavoxate Skeletal muscle relaxants
doxepin oxybutynin cyclobenzaprine
Assess the ability of patients with dry mouth to swallow solid dosage forms and assist in exploring alternative options.
Whenever possible, treatment should be directed towards the underlying cause of dry mouth. However, since most systemic
illnesses causing dry mouth are not curable, management is usually directed towards treatment and prevention of
complications and symptomatic control of dry mouth.
Dental Care
Inform patients they are at increased risk of dental caries because of their decreased saliva,6 and advise them to visit their
dentist and dental hygienist for regular checkup and practice regular brushing and flossing of the teeth. Remind patients with
xerostomia to avoid sugary or acidic foods or beverages, to help prevent dental caries.
Salivary Flow Stimulation
If the patient's salivary glands are still functioning, physiologic stimulation of saliva flow can be accomplished through
masticatory or gustatory stimuli.6 Encourage patients to chew sugarless gum or suck on sugarless hard candies as needed
throughout the day. These substances are sweetened using an alcohol sugar such as xylitol, mannitol, maltitol, lactitol or
erythritol, and do not promote dental caries.19 Labels should be carefully read to ensure the product does not contain simple
sugars such as glucose, fructose, sucrose, lactose and maltose, which are cariogenic.19
Water Consumption
For general good health it is important that people have sufficient fluid intake. However, unless xerostomia is due to
dehydration, patients should not assume that drinking large volumes of water will overcome oral dryness. Frequent small
sips of water during the day and sucking on ice chips will help relieve oral symptoms. Lemon juice should be avoided since it
depletes the salivary glands of saliva and may erode tooth enamel.20 The use of saliva substitutes may be more convenient
for patients during the day or those awakened at night with dry mouth symptoms. Frequent intake of water at night can lead
to nocturia and interrupted sleep.
For comparative ingredients of nonprescription product, consult the Compendium of Products for Minor Ailments—Mouth
Products: Dry Mouth.
Saliva Substitutes
Artificial saliva products can help to replace moisture and lubricate the mouth. They are formulated to mimic natural saliva,
but not to stimulate salivary gland production.21 Artificial saliva substitutes cannot replace all the functions of saliva and
their action is short-lived due to swallowing.6,22 Use has not been shown to prevent caries or oral candidiasis; therefore, they
must be considered as replacement therapy rather than a cure.2,6 These products come in a variety of formulations including
solutions, sprays, patches, gels and lozenges and are most convenient for patients to use while travelling or talking and to
prevent nocturia from increased fluid intake during the night. They are most useful when used immediately before bedtime or
speaking.23 They contain agents to optimize viscosity, such as hydroxymethylcellulose or carboxymethylcellulose, as well as
electrolytes and flavouring (see Table 4).2 There are limited data to suggest superiority of any of the products; therefore,
selection should be based on availability and personal preference.23 For cracked lips that may be sore, suggest using
petroleum jelly.20
Moi-Stir, available as a spray or swabs, contains electrolytes normally present in saliva, including the chloride salts of
calcium, magnesium, potassium and sodium, as well as sodium phosphate dibasic. Mouth Kote is a mouth moisturizer
composed of yerba santa, water, xylitol, sorbitol and citric acid. Yerba santa (Eriodictyon californicum) is said to have
expectorant properties and is used as a flavouring agent.24,25
OraMoist patch is composed of synthetic polymers, xylitol and enzymes such as glucose oxidase and lysozyme. The patch
adheres to the hard palate or the inside of the cheeks and dissolves over a period of 2–4 hours.
Oral Balance gel is an oral moisturizer containing a synthetic polymer, polyglycerylmethacrylate, and the salivary enzymes
lactoperoxidase and glucose oxidase. In patients with dry mouth secondary to radiation of the salivary glands, it afforded
more relief to patients with severe xerostomia than to those with moderate xerostomia.26 The duration of its moistening
effect averaged 1 hour during the daytime and more than 4 hours during the night.26
The Biotene line of dry mouth products, including toothpaste, mouthwash and gum, contain salivary enzymes,
lactoperoxidase, glucose oxidase and lysozyme, the goal being to replace the missing salivary enzyme activity in patients
with salivary hypofunction. Patients with dry mouth due to radiation therapy for head and neck cancer have anecdotally
reported improvement in their oral symptoms with the use of these products.27,28 Patients with xerostomia following
radiation therapy preferred the taste and consistency of Biotene toothpaste and Oral Balance gel over commercial
toothpastes and carboxymethylcellulose gel, but symptom improvement did not reach statistical significance.27
Sialogogues
Anethole trithione stimulates the parasympathetic nervous system and increases the secretion of acetylcholine. While it has
been used for many years in the treatment of chronic xerostomia, reports differ as to its efficacy. Further research is needed
to establish its safety and efficacy for this indication.29,30
Another sialogogue is the cholinergic agonist pilocarpine.6,31 It stimulates the exocrine glands with a duration action of 3–5
hours.32 The lowest effective and tolerated dose should be used for maintenance therapy. Salivary secretion is maximally
stimulated approximately 1 hour after administration of pilocarpine. No tolerance to the secretagogue effects of pilocarpine
has been reported, nor has long-term improvement in baseline salivary function been found. Increased salivary output is
transient, dose-related and consistent.33 Pilocarpine is effective in patients with Sjögren's syndrome and in those who
develop xerostomia while receiving radiation therapy for head or neck cancer.33 Pilocarpine administered as a mouthwash,
by diluting pilocarpine eye drops in water to make a 1–2% pilocarpine solution, has been used effectively to increase salivary
flow without any systemic side effects.34 Its use to treat medication-induced xerostomia is not a Health Canada–approved
indication. Use of pilocarpine is contraindicated in patients with uncontrolled asthma or when miosis is undesirable (e.g.,
acute iritis, angle-closure glaucoma).23
Dental Care
The use of fluoride is very important in preventing dental caries in patients with xerostomia. It is applied professionally by the
dentist or hygienist and maintained by the patient through daily use of high-fluoride–containing toothpastes (e.g., Prevident)
or mouth rinses (e.g., Oral B Fluoride 0.05%, alcohol-free). Sodium fluoride rinses 0.05% used twice daily have been effective
in preventing demineralization of enamel in patients with xerostomia while receiving radiation therapy.35 Patients should
avoid use of commercial mouth rinses containing alcohol since alcohol has a drying effect on the oral mucosa.23
Reassess patients advised to practice appropriate self-care for dry mouth after 1 week. If they are achieving improved mouth
comfort through increased intake of fluids and use of sugarless candy and are practicing good dental hygiene, encourage them
to continue these measures. Encourage them to seek the advice of a dentist on the care of their teeth and for evaluation of the
cause of their dry mouth when appropriate. Evaluate patient acceptance of a saliva substitute (taste, dosage form, degree of
comfort attained). Advise patients who are not achieving mouth comfort with one product to try another.22 If mouth
complications arise (e.g., oral candidiasis) or the dryness worsens, further evaluation by a healthcare practitioner is necessary.
If pilocarpine has been prescribed, monitor the patient for excessive cholinergic side effects such as sweating and flushing. If no
improvement in mouth discomfort is noted after 1 week of use, dosage adjustment may be necessary.
Resource Tips
Mayo Clinic. Diseases and Conditions. Dry mouth. Available from: www.mayoclinic.com/health/dry-mouth/HA00034.
National Institute of Dental and Craniofacial Research. Dry mouth (xerostomia). Available from:
www.nidcr.nih.gov/OralHealth/Topics/DryMouth.
Sjögren's Syndrome Foundation. Available from: www.sjogrens.org. Offers useful resources for people with Sjögren's syndrome,
including management of dry mouth. Contact them for information concerning The Moisture Seekers newsletter.
Algorithms
Figure 1: Assessment of Patients with Dry Mouth
Drug Table
Table 4: Pharmacologic Therapy for Dry Mouth

Effects
Drug Class: Saliva Substitutes
electrolyte solution Spray 1–2 No known No known significant Safe to swallow.

Moi-Stir puffs into significant drug interactions.
mouth PRN adverse
$ effects.
polyglycerylmethacrylate/lactoperoxidase/glucose Apply gel No known No known significant Safe to swallow.

oxidase onto tongue significant drug interactions.
Biotene Oral Balance and spread adverse
thoroughly effects.
$ inside the
mouth PRN
Effects
xylitol/polyvinylpyrrolidone/glucose oxidase/ Attach one Patch may not No known significant Some users may
lysozyme patch to the dissolve drug interactions. not like the
OraMoist hard palate completely, taste.
or the inside necessitating
$ of the manual
cheeks Q2– removal. May
4H PRN cause burning
and irritation at
application site.
Leaves sticky
residue in
mouth.
yerba santa Spray 3–5 No known No known significant Safe to swallow.

Mouth Kote puffs into significant drug interactions.
mouth PRN; adverse
$ swirl in effects.
mouth for 10
s then spit
Drug Class: Sialogogues
anethole trithione 25 mg TID Diarrhea, urine No known significant Requires several

Sialor po before discolouration. drug interactions. days of
meals Contraindicated treatment to
$$ in patients with show efficacy.
jaundice or
biliary tract
obstruction.
pilocarpine 5–10 mg TID Asthenia, chills, May cause cardiac May require up
Salagen po conjunctivitis, conduction to 12 wk of
Reduce dizziness, disturbance if taken treatment to
$$$ starting and headache, concomitantly with show dry mouth
maintenance hyperhidrosis, beta-blockers. May symptom
doses in myalgia, cause additive effects improvement.
patients with nausea, when taken with drugs An
hepatic pruritus, rash, exhibiting extemporaneous
impairment rhinitis, skin parasympathomimetic preparation of a
flushing, activity. May pilocarpine 1–
tachycardia, antagonize 2% mouthwash
taste anticholinergic effects has been used
perversion, of anticholinergic to increase
tremor, drugs. Inhibits salivary flow. Its
vomiting. CYP2A6 and therefore use to treat
may affect the medication-
pharmacokinetics of induced
CYP2A6 substrates. xerostomia is
not a Health
Canada–
approved
indication.
a
Cost of smallest available pack size or 30-day supply of tablets; includes drug cost only.
Legend: $ < $50 $$ $50–100 $$$ $100–150
Suggested Readings
Delli K, Spijkervet FK, Kroese FG et al. Xerostomia. Monogr Oral Sci 2014;24:109-25.
Furness S, Worthington HV, Bryan G et al. Interventions for the management of dry mouth: topical therapies. Cochrane Database
Syst Rev 2011;12:CD008934.
Pinna R, Campus G, Cumbo E et al. Xerostomia induced by radiotherapy: an overview of the physiopathology, clinical evidence,
and management of the oral damage. Ther Clin Risk Manag 2015;11:171-88.
Plemons JM, Al-Hashimi I, Marek CL et al. Managing xerostomia and salivary gland hypofunction: executive summary of a report
from the American Dental Association Council on Scientific Affairs. J Am Dent Assoc 2014;145:867-73.
Villa A, Connell CL, Abati S. Diagnosis and management of xerostomia and hyposalivation. Ther Clin Risk Manag 2014;11:45-51.
References
1. Dawes C. Physiological factors affecting salivary flow rate, oral sugar clearance, and the sensation of dry mouth in man.
J Dent Res 1987;66:648-53.
2. Holmes S. Xerostomia: aetiology and management in cancer patients. Support Care Cancer 1998;6:348-55.
3. Glazar I, Urek MM, Brumini G et al. Oral sensorial complaints, salivary flow rate and mucosal lesions in the
institutionalized elderly. J Oral Rehabil 2010;37:93-9.
4. Greenspan D. Xerostomia: diagnosis and management. Oncology (Williston Park) 1996;10:7-11.
5. Bartels CL. Xerostomia. Helping patients with dry mouth. Available from:
www.oralcancerfoundation.org/dental/xerostomia.htm. Accessed February 3, 2016.
6. Daniels TE, Wu AJ. Xerostomia–clinical evaluation and treatment in general practice. J Calif Dent Assoc 2000;28:933-41.
7. Sweeney MP, Bagg J, Baxter WP et al. Oral disease in terminally ill cancer patients with xerostomia. Oral Oncol
1998;34:123-6.
8. Filshie J, Rubens CN. Complementary and alternative medicine. Anesthesiol Clin 2006;24:81-111, viii.
9. Bossola M, Tazza L. Xerostomia in patients on chronic hemodialysis. Nat Rev Nephrol 2012;8:176-82.
10. Napeñas JJ, Brennan MT, Fox PC. Diagnosis and treatment of xerostomia (dry mouth). Odontology 2009;97:76-83.
11. Dyke S. Clinical management and review of Sjögren's syndrome. Int J Pharm Compound 2000;4:338-41.
12. Pray SW. Help for patients with dry mouth. US Pharm 2000;25:16, 19-22.
13. Korsten MA, Rosman AS, Fishbein S et al. Chronic xerostomia increases esophageal acid exposure and is associated
with esophageal injury. Am J Med 1991;90:701-6.
14. Zunt S. Evaluation of the dry mouth patient. Alpha Omegan 2007;100:203-9.
15. American Dental Association. ADA guide to dental therapeutics. 1st ed. Chicago: ADA Publishing; 1998.
16. Sreebny LM, Schwartz SS. A reference guide to drugs and dry mouth. Gerodontology 1986;5:75-99.
17. Wynn RL, Meiller TF. Drugs and dry mouth. Gen Dent 2001;49:10-2, 14.
18. Sreebny LM, Schwartz SS. A reference guide to drugs and dry mouth–2nd edition. Gerodontology 1997;14:33-47.
19. Hayes C. The effects of non-cariogenic sweeteners on the prevention of dental carries: a review of the evidence. J Dent
Educ 2001;65:1106-9.
20. Taubert M, Davies EM, Back I. Dry mouth. BMJ 2007;334:534.
21. Flynn AA. Counseling special populations on oral health care needs: Am Pharm 1993;NS33:33-9.
22. Wynn RL, Meiller TF. Artificial saliva products and drugs used to treat xerostomia. Gen Dent 2000;48:630-6.
23. Guggenheimer J, Moore PA. Xerostomia: etiology, recognition and treatment. J Am Dent Assoc 2003;134:61-9.
24. Natural Medicines Comprehensive Database. Yerba santa. Available from: naturaldatabase.therapeuticresearch.com.
Accessed February 6, 2016. Subscription required.
25. Yerba santa monograph. In: Review of natural products. St. Louis: Facts and Comparisons; 1991.
26. Regelink G, Vissink A, Reintsema H et al. Efficacy of a synthetic polymer saliva substitute in reducing oral complaints of
patients suffering from irradiation-induced xerostomia. Quintessence Int 1998;29:383-8.
27. Epstein JB, Emerton S, Le ND et al. A double-blind crossover trial of Oral Balance gel and Biotene toothpaste versus
placebo in patients with xerostomia following radiation therapy. Oral Oncol 1999;35:132-7.
28. Warde P, Kroll B, O'Sullivan B et al. A phase II study of Biotene in the treatment of postradiation xerostomia in patients
with head and neck cancer. Support Care Cancer 2000;8:203-8.
29. Ferguson MM. Pilocarpine and other cholinergics drugs in the management of salivary gland dysfunction. Oral Surg Oral
Med Oral Pathol 1993;75:186-91.
30. Hamada T, Nakane T, Kimura T et al. Treatment of xerostomia with the bile secretion-stimulant drug anethole trithione: a
clinical trial. Am J Med Sci 1999;318:146-51.
31. Vivino FB, Al-Hashimi I, Khan Z et al. Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients
with Sjögren syndrome: a randomized, placebo-controlled, fixed-dose, multicentre trial. P92-01 Study Group. Arch Intern
Med 1999;159:174-81.
32. Salagen tablets. In: Physicians' desk reference. 51st ed. Montvale: Medical Economics Books; 1997. p. 1546-7.
33. Fox PC, Alkinson JC, Macynski AA et al. Pilocarpine treatment of salivary gland hypofunction and dry mouth
(xerostomia). Arch Intern Med 1991;151:1149-52.
34. Bernardi R, Perin C, Becker FL et al. Effect of pilocarpine mouthwash on salivary flow. Braz J Med Biol Res 2002;35:105-
10.
35. Meyerowitz C, Featherstone JD, Billings RJ et al. Use of an intra-oral model to evaluate 0.05% sodium fluoride mouth
rinse in radiation-induced hyposalivation. J Dent Res 1991;70:894-8.
Halitosis
Shirin Abadi, BSc(Pharm), ACPR, PharmD, MBA, FCSHP

Introduction
Halitosis, bad breath, fetor ex ore, fetor oris and oral malodor are all terms used to describe unpleasant or
offensive odours emitted in the exhaled breath. In its simplest form, bad breath may be related to
substances ingested such as herbs, spices, garlic, onion, tobacco or alcohol. With a reported prevalence as
high as 50%, halitosis can be of great concern to many patients.1 Given the growing interest, the diagnosis
and treatment of halitosis are being incorporated into routine dental care, and specialized dental and
multidisciplinary clinics are being set up solely for the treatment of patients with halitosis.2
Pathophysiology
Halitosis can be broadly classified into 3 main categories (Figure 1). Genuine halitosis occurs when oral
malodor is truly present. Pseudohalitosis occurs when oral malodor is of concern to the patient, but is not
perceived by others. Halitophobia occurs when the patient believes halitosis is present, despite having
received treatment for genuine halitosis or pseudohalitosis, while lacking any physical or social evidence for
the presence of bad breath.1
Figure 1: Classification of Halitosis
Physiologic halitosis arises from the putrefactive process, the decomposition of organic matter by
microorganisms within the mouth, especially at the back of the tongue. The major elements in the
production of oral malodor are volatile sulphur compounds (VSC), primarily hydrogen sulfide, methyl
mercaptan and dimethyl sulfide (breakdown products of methionine and cysteine), as well as indole and
skatole (breakdown products of tryptophan) and cadaverine (breakdown product of lysine).3 Halitosis
usually occurs when there is a shift from gram-positive to gram-negative anaerobic proteolytic bacteria such
as Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia and spirochetes.3 Gram-
positive anaerobic bacteria such as Solobacterium moorei may also be involved in the initial stages of the
production of bad breath.3 Ingestion of systemic antibiotics or regular use of an antibacterial mouthwash
can put the patient at risk of overgrowth of anaerobic, odoriferous bacteria or fungi that can be a source of
bad breath. Other contributing factors to bad breath include decreased salivary flow, reduced carbohydrate
substrate and increased pH.3,4,5 The oral cavity is the main source of halitosis in most healthy individuals.5
Pathologic halitosis is caused by disease or malfunction of the oral tissues (e.g., gingivitis, dental abscess
or jaw osteonecrosis), and includes halitosis due to periodontal disease and xerostomia (dry mouth).
Xerostomia may be due to a number of factors, including insufficient water intake, breathing through the
mouth, medication use (e.g., anticholinergic agents), excessive use of alcohol-based mouthwash, radiation
therapy, chronic medical conditions (e.g., depression), smoking and regular caffeine intake. Extraoral
pathologic halitosis refers to malodor originating from sources other than the mouth. These may include the
nasal, paranasal and laryngeal regions, the upper digestive tract and the lungs, or disorders in any other
body system (e.g., diabetes mellitus, hepatic cirrhosis, uremia, malignancy or internal bleeding). Nasal
malodor is the most common origin of extraoral halitosis, and may be due to a nasal infection (e.g.,
sinusitis), problems affecting airflow or mucous secretions (e.g., polyps, postnasal drip) or craniofacial
anomalies (e.g., cleft palate).3
Pseudohalitosis and halitophobia may have a psychological component, which require the expert advice of a
mental health specialist for appropriate management.
There is no reliable way for people to properly assess their breath odour other than organoleptic (human
nose) assessments. Some people have a lifelong concern with having bad breath, while at the other
extreme, others do not seem to notice that their breath is offensive. Also, the perception of oral malodour
differs among members of different cultures.4,6
Goals of Therapy
Identify and resolve causes of halitosis
Eliminate or minimize signs and symptoms of halitosis
Encourage safe and effective oral hygiene and regular dental care
Prevent recurrences and complications
Improve self-confidence and quality of life
Patient Assessment
Evaluate patients seeking help for bad breath based on their personal, dental and medical history (Figure 2).
Information collected should include the patient's specific symptoms and complete medication history, the
types of food ingested, tobacco use and alcohol and caffeine intake, as well as whether there are any
specific times during which bad breath is most noticeable. Certain foods (e.g., garlic) are known to cause
bad breath, and tobacco and alcohol use may also contribute to halitosis. Most people have bad breath
upon awakening. Irregular eating can also lead to hunger ketosis and bad breath. Poor dental hygiene, as
well as pain and discomfort in the mouth and oral cavity, may signify pathology that requires treatment.
Assess patients who wear dentures to determine proper denture hygiene. The long-term use of
mouthwashes with alcohol content or antibacterial agents may also contribute to halitosis. For patients
experiencing frequent dry mouth, it is important to identify and treat its cause (see Dry Mouth). Patients with
halitosis, pseudohalitosis or halitophobia complicated by other medical conditions or symptoms require
further assessment.
The oral cavity is the source of bad breath in the majority of patients, and good oral hygiene along with the
treatment of any periodontal or oral disease is necessary to relieve the problem. Encourage patients to visit
a dental care professional for assessment of oral diseases and for removal of dental plaque and
accumulated bacteria on the dorsum of the tongue and in the periodontal pockets. Encourage tooth
brushing with a soft-bristled toothbrush at least twice a day, and flossing daily.7
A clean tongue is a healthy pink colour. A whitish haze on the tongue can indicate bacterial or fungal
buildup.8 Cleaning the tongue along with other oral hygiene measures may be helpful in decreasing
physiologic halitosis.8,9 Tongue cleaning can be accomplished through the use of a soft, small-headed,
child-size toothbrush, or by using a specially designed tongue cleaner or tongue scraper.10 The tongue is
stroked from the back to the tip with the brush or cleaner, then the mouth is rinsed with water. The posterior
portion of the tongue is the most important area to clean, but care should be taken not to induce gagging.
It is also important for patients to understand that they should not be overzealous in their cleaning, to avoid
causing damage to and bleeding from the tongue's surface. Tongue scrapers must be used cautiously and
adult toothbrushes are not recommended for tongue cleaning.1 Cleaning the tongue with either a cleaner or
a scraper may reduce VSC levels more than by cleaning with a toothbrush.8 However, this reduction in VSC
levels may not be long-lasting.8
Drinking plenty of fluids and cleaning the mouth after consuming dairy products, meat or fish are adjunctive
measures for treating bad breath.11 Saliva has many functions in keeping the mouth healthy, including
lubrication, oxygenation, buffering and antimicrobial action. Increasing saliva flow and tongue action help
decrease bad breath; chewing sugarless gum and munching on fibrous vegetables, such as raw carrots and
celery, can help accomplish this.8,12
Mouthwash
Mouthwashes may supplement oral hygiene. Regular use of a mouthwash may reduce bad breath but
single-use mouthwashes may have only a short-term benefit.13 Most commercial mouthwashes mask
odours and provide antiseptic properties for a relatively short time (less than 30 minutes).5 Rinsing with
water is of little help because water offers no antiseptic properties and can wash away saliva, which
does have these properties.8 The action of mouthwashes is optimized when deeply gargled (in addition
to rinsing) prior to going to bed. Residues of the oral rinse may remain in the mouth longer during sleep
as the individual is not eating or drinking; this is also the time when bacterial activity is at its highest due
to decreased salivary flow.14 The quality of the available evidence supporting the effectiveness of
mouthwashes is low, due to sparse data and various methodological flaws (e.g., diversity in the baseline
characteristics of the participants and the methods used to assess outcomes).15
Chlorhexidine gluconate 0.12% mouthwash appears to be effective in reducing oral malodor by exerting
its antibacterial activity on supragingival plaque and the tongue.15 Its side effects include tooth staining
and taste disturbances.15,16,17 Chlorhexidine mouthwashes are not recommended to be used for more
than one week and should be discontinued if mouth ulcers are present.3
Regular use of cetylpyridinium-containing mouthwashes may reduce bad breath at 2 weeks, while the
regular use of sodium chlorite-containing mouthwashes may reduce bad breath at 4 weeks.13 Sodium
chlorite is not commercially available in Canada.
Chlorine dioxide and zinc-containing mouthwashes (e.g., zinc lactate 0.14%, zinc chloride) may be
effective in neutralizing odoriferous sulphur compounds.15,18,19,20,21 Zinc-containing mouthwashes may
be more effective at concentrations ≥1%.17 However, chlorine dioxide and zinc lactate are not
commercially available in Canada.
Mouthwashes containing essential oils (e.g., eucalyptol) may be successful in reducing moderate
malodor.16 A potential role may exist for agents such as triclosan, hydrogen peroxide, dehydroascorbic
acid, sodium bicarbonate, iminium, allylpyrocatechol, L-trifluoromethionine and medications used for
Helicobacter pylori eradication.17 Further large, well-designed, randomized controlled trials that examine
the long-term use of mouthwashes are required to identify the role of these agents in the management
of halitosis.
Combination mouthwashes, such as those containing chlorhexidine and cetylpyridinium chloride,

chlorhexidine and zinc, or chlorhexidine, cetylpyridinium chloride and zinc, have demonstrated enhanced
effectiveness on VSC levels in clinical trials.15 It is thought that chlorhexidine and cetylpyridinium may
exert a synergistic antimicrobial effect against VSC-producing bacteria, and zinc may transform volatile
sulphur compounds into non-odoriferous breakdown products.15 However, well-designed trials are
needed to further establish the safety and efficacy of these combination products, which are not
commercially available in Canada. There are currently no other pharmacologic therapies with an
established role for the treatment of bad breath available in Canada, unless bad breath is caused by
decreased salivary flow (see Dry Mouth).
Ailments—Mouth Products: Mouthwashes.
Chlorophyll, parsley, menthol and mint have been known as breath fresheners for many years. Garcinia
mangostana (mangosteen) may also play a role in reducing VSC levels.15 However, there is insufficient
reliable evidence supporting regular use of these products for the management of halitosis.15,17,22
After 1 week of practising good oral hygiene including gentle cleaning of the tongue, the patient should see
an improvement in their bad breath and this routine should be continued. If the patient's tongue hurts or
bleeds following cleaning, or if tongue cleaning causes excessive gagging, it is likely that further instruction
on tongue cleaning is required. Dentists and dental hygienists may be better situated to give these
instructions.
Mouthwashes containing antibacterial agents such as chlorhexidine and cetylpyridinium may stain the
teeth.15 Zinc-containing mouthwashes may cause a metallic taste in the mouth. Products containing
alcohol may cause dryness with long-term use, which can exacerbate bad breath. Monitor the duration of
use of these products when possible, and discourage the use of products containing alcohol or antibacterial
agents.
Resource Tips
American Academy of Family Physicians. Family Doctor. Halitosis. Available from:
familydoctor.org/familydoctor/en/diseases-conditions/halitosis.html.
Mayo Clinic. Diseases and Conditions. Bad breath. Available from: www.mayoclinic.org/diseases-
conditions/bad-breath/basics/definition/con-20014939.
Yaegaki K, Coil JM. Examination, classification, and treatment of halitosis; clinical perspectives. J Can Dent
Assoc 2000;66:257-61.
Algorithms
Figure 2: Assessment of Patients with Halitosis

Denture
a See Dry Mouth.

b See Bad Breath—What You Need to Know.
Suggested Readings
Bollen CM, Beikler T. Halitosis: the multidisciplinary approach. Int J Oral Sci 2012;4:55-63.
Fedorowicz Z, Aljufairi H, Nasser M et al. Mouthrinses for the treatment of halitosis. Cochrane Database Syst
Rev 2008;(4):CD006701.
Rösing CK, Loesche W. Halitosis: an overview of epidemiology, etiology and clinical management. Braz Oral
Res 2011;25:466-71.
Scully C, Greenman J. Halitology (breath odour: aetiopathogenesis and management). Oral Dis 2012;18:333-
45.
Van den Broek AM, Feenstra L, de Baat C. A review of the current literature on management of halitosis. Oral
Dis 2008;14:30-9.
References
References
1. Yaegaki K, Coil JM. Examination, classification, and treatment of halitosis; clinical perspectives. J
Can Dent Assoc 2000;66:257-61.
2. Bollen CM, Beikler T. Halitosis: the multidisciplinary approach. Int J Oral Sci 2012;4:55-63.
3. UpToDate. Rosenberg M. Bad breath. Available from: www.uptodate.com. Accessed March 3, 2016.
Subscription required.
4. Scully C, Greenman J. Halitology (breath odour: aetiopathogenesis and management). Oral Dis
2012;18:333-45.
5. Messadi DV. Oral and nonoral sources of halitosis. J Calif Dent Assoc 1997;25:127-31.
6. Eli I, Baht R, Koriat H et al. Self-perception of breath odor. J Am Dent Assoc 2001;132:621-6.
7. Weinberg. MA. Halitosis: the “bad breath” syndrome. US Pharm 2001;26:46, 48, 51-52, 57.
8. Van der Sleen MI, Slot DE, Van Trijffel E et al. Effectiveness of mechanical tongue cleaning on breath
odour and tongue coating: a systematic review. Int J Dent Hyg 2010;8:258-68.
9. Outhouse TL, Al-Alawi R, Fedorowicz Z et al. Tongue scraping for treating halitosis. Cochrane
10. Seemann R, Kison A, Bizhang M et al. Effectiveness of mechanical tongue cleaning on oral levels of
volatile sulfur compounds. J Am Dent Assoc 2001;132:1263-7.
11. Carlson-Mann L. The use of tongue cleaners in the treatment of halitosis. Probe 1998;32:114-5.
12. Reingewirtz Y, Girault O, Reingewirtz N et al. Mechanical effects and volatile sulfur compound-
reducing effects of chewing gums: comparison between test and base gums and a control group.
Quintessence Int 1999;30:319-23.
13. Scully C, Porter S. Halitosis. Clin Evid (Online) 2008.pii:1305.
14. Rosenberg M. Clinical assessment of bad breath: current concepts. J Am Dent Assoc 1996;127:475-
82.
15. Fedorowicz Z, Aljufairi H, Nasser M et al. Mouthrinses for the treatment of halitosis. Cochrane
16. Loesche WJ. The effects of antimicrobial mouthrinses on oral malodor and their status relative to
US Food and Drug Administration regulations. Quintessence Int 1999;30:311-8.
17. Van den Broek AM, Feenstra L, de Baat C. A review of the current literature on management of
halitosis. Oral Dis 2008;14:30-9.
18. Borden LC, Chaves ES, Bowman JP et al. The effect of four mouthrinses on oral malodor. Compend
Contin Educ Dent 2002;23:531-6, 538, 540.
19. Kozlovsky A, Goldberg S, Natour I et al. Efficacy of a 2-phase oil: water mouthrinse in controlling oral
malodor, gingivitis, and plaque. J Periodontol 1996;67:577-82.
20. Rassameemasmaung S, Sirikulsathean A, Amornchat C et al. Effects of herbal mouthwash
containing the pericarp extract of Garcinia mangostana L on halitosis, plaque and papillary bleeding
index. J Int Acad Periodontol 2007;9:19-25.
21. Winkel EG, Roldan S, Van Winkelhoff AJ et al. Clinical effects of a new mouthrinse containing
chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-centre, double-blind,
placebo-controlled study. J Clin Periodontol 2003;30:300-6.
22. Natural Medicines Comprehensive Database. Stockton: Therapeutic Research Facility; 2009.
Available from: naturaldatabase.therapeuticresearch.com. Accessed March 3, 2016. Subscription
required.

Bad Breath
Bad Breath—What You Need to Know
What causes bad breath?
The most common cause of bad breath is a problem with your teeth or gums. If you have not seen a dentist or a dental
hygienist recently, make an appointment. They can find out if your teeth or gums are causing bad breath.
Another cause of bad breath is dry mouth. It can cause problems with your teeth and with eating. Many medications can
cause dry mouth. If you have this problem, please talk to your pharmacist.
Nose and throat problems, and some other diseases, can also cause bad breath. If you think you may have a condition that
could be causing bad breath, please talk to your health-care provider.
Things you can do to help stop bad breath:
Take good care of your teeth and gums. Brush your teeth at least twice a day using a soft toothbrush. Replace
your toothbrush at least every 3 months. Floss between your teeth at least once a day.
To remove bacteria, brush the back of your tongue gently using a soft child-size toothbrush. Ensure that you are
using the right tongue-cleaning procedure by asking your dentist or dental hygienist.
Visit the dentist and dental hygienist regularly; once a year is good, every 6 months is better.
You can try using a mouthwash at bedtime. Mouthwashes are unlikely to provide long-lasting relief. They work
for a longer period of time if you swish them in your mouth for 30 seconds and gargle for 30 seconds before
spitting and if you do not eat or drink for at least 30 minutes after using them.
Avoid regular use of mouthwashes containing alcohol or antibacterial agents. The alcohol in the mouthwash
can make your mouth dry, and your breath worse. The antibacterial agent in the mouthwash can lead over time
to the excessive growth of resistant bacteria or microbes that can cause bad breath.
Some mouthwashes contain an ingredient that may stain your teeth, such as chlorhexidine and cetylpyridinium.
Check with your pharmacist before choosing a mouthwash.
If you wear removable dentures:
Rinse dentures with water after meals to remove loose food debris
Brush dentures with lukewarm water, soap or a denture paste, using a denture brush or a regular soft
toothbrush at least twice a day to remove plaque and food debris and to help prevent stains
Brush your gums and any natural teeth using a separate soft toothbrush at least 2 times a day
Take dentures out at bedtime; clean and store them appropriately
If you wear removable braces, it is also important to keep them clean. Ask your dentist for directions on how
best to keep your braces clean.
Avoid using tobacco and regular alcoholic and caffeinated beverages. They can cause bad breath.
Eat regular meals, including breakfast, and avoid long periods of hunger.
Snack on foods that require lots of chewing, such as raw celery and carrot sticks. Chewing causes saliva to flow
and helps keep your breath fresh.
Chew sugarless gum. This will also cause saliva to flow.
Consume fewer substances associated with bad breath, such as garlic and spicy foods.
Drink plenty of fluids during the day.
Oral Candidiasis
Karen Wlock, BScPharm

Pathophysiology
Candida organisms are fungi that normally live as commensals in the human oral cavity.1 It is estimated that
up to 60% of healthy, immunocompetent adults carry Candida species as part of their normal oral flora.2,3
However, when the normal flora is compromised (e.g., by weakened host defence mechanisms), Candida
overgrowth and direct tissue invasion may occur, leading to the development of opportunistic disease.1,3
Oral candidiasis, also known as oral thrush, oral candidosis, or moniliasis, is a mucocutaneous opportunistic
infection caused by Candida species. Host factors are believed to play a more significant role than the
virulence of Candida in the pathogenesis of disease.1
Oral candidiasis is often denoted as a “disease of the diseased” since it selectively occurs in individuals with
weakened host defence mechanisms.1,4 Oral candidiasis is the most common fungal infection found in
both immunocompetent and immunocompromised populations, with prevalence greatest among infants
and the elderly.5,6 Xerostomia, experienced by 30–77% of palliative care cancer patients secondary to
cancer treatment and medications administered for symptom relief, predisposes these individuals to oral
candidiasis.7
The high incidence of oral candidiasis in humans can be explained by a multiplicity of predisposing factors
(Table 1).
Table 1: Risk Factors for Developing Oral Candidiasis

Disease States Medications
Addison's disease Broad-spectrum antibiotics
Anemia (due to iron, folic acid or vitamin B12 Cytotoxic chemotherapy
deficiency) Immunosuppressive drugs
Diabetes mellitus Inhaled corticosteroids
Human immunodeficiency virus (HIV) infection Other
and AIDS
Infancy and childhood (due to an
Hypothyroidism underdeveloped immune system)
Leukemia Local mucosal trauma
Xerostomia (dry mouth): may be caused by Poor dental or denture hygiene (particularly in
anticholinergic drugs, radiation therapy, dental the elderly)
appliances
Pregnancy
Smoking tobacco
C. albicans, reported to account for up to 80% of Candida species isolated from the oral cavity, is considered
the major cause of oral candidal infections.1,3,8 Other Candida species that cause infection to a lesser
extent include C. glabrata, C. tropicalis, C. krusei and C. dubliniensis.1,9
The human immunodeficiency virus (HIV) pandemic has contributed greatly to the resurgence of oral
candidal infections in humans.9 Up to 90% of HIV-infected individuals are expected to develop oral
candidiasis at some point during their disease and, because of this trend, oral candidal infection is often
used as a clinical marker to predict HIV disease progression.4,9,10
Goals of Therapy
Resolve infection or reduce acute candidal overgrowth to a level which can be controlled by the host's
defences and thereby prevent complications (e.g., progression to esophageal candidiasis).11
Prevent recurrences by managing any underlying risk factors (e.g., use of inhaled corticosteroids, poor
dental hygiene, uncontrolled diabetes mellitus) and instituting antifungal prophylaxis if warranted (e.g.,
in high-risk patients with HIV/AIDS or advanced cancer).
Patient Assessment
Candidal infections are often associated with predisposing factors; therefore, a thorough medical/dental
history is required to identify and manage any underlying conditions that may be contributing to the
infection. In addition, physical examination of the lesions and a description of the signs and symptoms are
paramount to an accurate diagnosis and the differentiation between the various clinical presentations (see
Figure 1). Diagnosis of any form of oral candidiasis is based on clinical recognition of typical lesions.
Microbiologic tests (e.g., smears, stains and cultures) can be used when doubts regarding diagnosis exist or
resistance to an antifungal agent is suspected. Various test methods for identifying the fungal species are
available.12 Empiric therapy with an antifungal medication is often reasonable when the diagnosis is
uncertain.
Candidiasis in the oropharyngeal region may be localized (primary oral candidiasis) or may be a
manifestation of generalized candidal infection (secondary oral candidiasis).9,13 Primary oral candidiasis
may present as several clinical variants, including acute pseudomembranous (thrush), erythematous or
hyperplastic candidiasis. Symptoms vary, and clinical presentation may range from no symptoms at all to a
burning sensation painful enough to interfere with swallowing and oral food intake, anorexia and weight
loss, nutritional deficiency and decreased quality of life.3,14 It is noteworthy that oral candidiasis may appear
with more than one group of symptoms simultaneously.15,16
Acute pseudomembranous candidiasis, commonly known as thrush, is characterized by creamy, whitish-

yellow, elevated plaques (pseudomembranes) on the mucosal lining of the mouth, most frequently on the
tongue, soft palate and inner cheek.2,9,15 The plaques are easily wiped off with a tongue blade, exposing a
raw, erythematous base that is not usually painful.1 Although typically an acute infection,
pseudomembranous candidiasis can persist for up to several months or years, especially in patients
receiving inhaled or intraoral topical corticosteroids or in HIV-infected individuals. This form of candidiasis is
most commonly diagnosed in the first few weeks of an infant's life, in elderly patients and in those with
underlying malignancies or HIV infection.1,16
Erythematous candidiasis, or atrophic candidiasis, can develop from pseudomembranous candidiasis as

plaques are shed, exposing the underlying erythematous lesions. These lesions vary in size, and are
accompanied by inflammation of the surrounding tissues. Erythematous lesions can be found on the palate
and on the tongue, where they can cause depapillation and dekeratinization.15 This form of candidiasis
often follows the use of broad-spectrum antibiotics (e.g., tetracycline) or the use of inhaled corticosteroids8
and is the most common variant in HIV infection.9,15,16
Hyperplastic candidiasis, or candidal leukoplakia, is a less common form of oral candidiasis predominantly
seen in smokers and males over 30 years of age.9 It is characterized by chronic, discrete lesions that appear
as small, translucent white plaques or larger, opaque lesions on the tongue, palate or inner cheek.1,9 The
white plaques cannot be easily wiped off as in the pseudomembranous variant.3,9 Leukoplakias are
considered to be premalignant; therefore, biopsy is recommended.3,9
Candida-associated lesions include denture stomatitis and angular cheilitis.9 Denture stomatitis presents as
chronic red, edematous lesions on the denture-bearing mucosa of denture wearers.1 Although patients are
usually symptomless, some experience mild soreness, burning or tingling beneath the denture.
Approximately 50% of complete denture wearers experience denture stomatitis.15 Commonly associated
with denture stomatitis is angular cheilitis, a mixed bacterial-fungal infection characterized by sore,
erythematous fissuring at the angles of the mouth.9,15,16 Angular cheilitis may also be a sign of vitamin B12,
folic acid or iron deficiency.3
The development of thrush associated with inhaled corticosteroids (ICS) is rare; the risk can be reduced by
the use of a spacer device with metered dose inhalers. Rinsing the mouth and gargling with water after
using an ICS or reducing the dose of the ICS when appropriate can also be helpful in preventing recurrent
episodes of oral candidiasis.
To aid in healing and prevention of oral candidiasis or angular cheilitis associated with wearing dentures,
advise patient to:
remove dentures overnight

wear dentures for no longer than 6 hours during the day, to allow the gums to heal and to reduce
inflammation
keep dentures clean and soak them in disinfectant solution when not in use
clean the gums, tongue and affected mucosa with a soft toothbrush
review proper fitting of dentures with an oral health practitioner
stop smoking.
Patients with oral candidiasis due to dry mouth caused by medication may benefit from a medication review
and assessment; a reduction in dose or stopping the offending agent may be helpful. Keeping the mouth
moist by taking frequent sips of water may also be helpful.
If patients with diabetes experience recurrent oral candidiasis, review diabetes control and refer to an
appropriate healthcare practitioner.
If an infant is experiencing thrush, advise parents to keep all toys and feeding bottles/nipples sterilized, to
prevent autoinfection and recurrence. If the mother is breastfeeding and also experiencing candidal
infection of the nipples, refer her to an appropriate healthcare practitioner for education regarding proper
latching and for possible dual pharmacologic treatment of mother and baby.
Elimination of the underlying factor(s) responsible for the opportunistic infection may be sufficient to allow
the microflora to return to normal. However, in the majority of cases treatment with an antifungal agent is
necessary.1 Inadequately treated or refractory oral candidiasis can be of particular concern in
immunocompromised or myelosuppressed patients, as an initially localized infection may lead to regional
(e.g., oropharyngeal to esophageal) or systemic (life-threatening candidemia) spread of the
microorganism.17
The pharmacologic agents most commonly used for the treatment of oral candidiasis fall into 3 major
categories (see Table 2): polyenes (nystatin), azoles (fluconazole, itraconazole, posaconazole) and
echinocandins (anidulafungin, caspofungin, micafungin).3,9,18 The echinocandins are administered
parenterally, therefore, these agents are rarely used for uncomplicated disease.
Topical nystatin oral suspension is the most commonly used treatment for oral candidiasis,4,9 and is
recommended for initial episodes and mild disease.19 Nystatin is well tolerated and does not interact with
other medications because it is largely not absorbed from the GI tract when administered orally.
Azoles are recommended as second-line agents due to the emergence of azole-resistant Candida strains.9
Resistance of fungi to polyenes is rare. C. glabrata and C. krusei are innately less susceptible to azoles, and
C. albicans can acquire azole resistance. Oral fluconazole is the most commonly recommended azole, and
is recommended for the treatment of moderate to severe disease.19 In cases of recurrent infections (e.g.,
patients with HIV/AIDS), fluconazole is considered the drug of choice for episodic treatment and chronic
suppression of oral candidiasis.9,10,19,20 However, in cases of fluconazole resistance, oral itraconazole or
posaconazole can be equally effective alternatives.9,21,22,23
Historically, gentian violet in 1% aqueous or USP (containing 10% alcohol) solution was applied locally for
the treatment of oral candidiasis.24 However, this agent causes mucosal irritation, ulceration and staining,
making it difficult to determine therapeutic progress and decreasing adherence.24 The safety of gentian
violet is also questionable, as it has been linked to carcinogenicity in animal studies.24,25
Evidence is insufficient to support probiotic therapy in the treatment or prevention of intraoral candidiasis.
However, 1 intervention study suggests that probiotic strains of lactobacilli and propionibacteria may be
effective in lowering oral Candida levels in the elderly.26 More clinical trials are required to determine the role
of probiotics in oral candidiasis therapy, especially with respect to dosing and antibiotic-induced disease.27
There is insufficient evidence to support the use of natural health products in the treatment of oral
candidiasis.28
For comparative ingredients of nonprescription products, consult the Compendium of Products of Minor
Ailments—Skin Care Products: Antifungals.
Since the majority of risk factors for developing a candidal infection are associated with
immunocompromised states, it is important to monitor susceptible individuals for signs and symptoms of
infection so that early treatment can be instituted and the infection can be resolved before spreading.
Monitor patients taking broad-spectrum antibiotics, undergoing chemotherapy or radiation therapy or those
who take corticosteroids orally or by inhalation for signs and symptoms of oral candidiasis. If identified in a
patient, prompt evaluation by an appropriate healthcare practitioner is necessary. Once antifungal treatment
is initiated, advise the patient to monitor symptoms on a daily basis during treatment and for up to 2 weeks
after clearing of symptoms to ensure the infection has completely resolved.
Resource Tips
Canadian Paediatric Society. Caring for Kids. Thrush. Available from:
www.caringforkids.cps.ca/handouts/thrush.
Algorithms
Figure 1: Assessment of Patients with Oral Candidiasis

Drug Table
Table 2: Pharmacologic Therapy for Oral Candidiasis

Effects
Drug Class: Antifungals, Azole

Effects
fluconazole Treatment: Abdominal Rifampin enhances Recommended

Diflucan, 100–200 pain, diarrhea, fluconazole metabolism for the
generics mg daily po nausea, which may necessitate treatment of
× 7–14 vomiting increased fluconazole dose moderate to
$ days when these 2 drugs are used severe
Preventive concomitantly. Decrease disease. In
therapy for dosage of midazolam and HIV/AIDS
recurrent triazolam if these drugs are patients,
infections: used with fluconazole. fluconazole is
100–200 Monitor for increased considered the
mg 3 times prothrombin time in patients drug of choice
weekly po receiving concomitant for treatment
fluconazole and warfarin. of oral
Monitor for increased candidiasis.
phenytoin plasma
concentration with
concomitant fluconazole
use. Monitor for
hypoglycemia when
fluconazole is used with
sulfonylureas (e.g.,
glyburide). Monitor for
increased cyclosporine levels
and serum creatinine in
patients receiving
fluconazole and
cyclosporine.
itraconazole Capsules: Abdominal Itraconazole is mainly The

Sporanox 100–200 pain, metabolized through itraconazole
Capsules, mg daily po constipation, CYP3A4. Other substances oral solution
Sporanox after a diarrhea, that either share this should be
Oral Solution meal × 2–4 dyspepsia, metabolic pathway or modify swished in the
wk heart failure, CYP3A4 activity may oral cavity and
$$ Solution: hepatotoxicity, influence the swallowed and
200 mg hypokalemia, pharmacokinetics of advise patient
daily po on nausea, itraconazole. Similarly, not to rinse
empty peripheral itraconazole may modify the mouth with
stomach × neuropathy, pharmacokinetics of other water after
1–3 wk pruritus, substances that share this swallowing.
pulmonary metabolic pathway because
edema, rash, itraconazole is a potent
urticaria, CYP3A4 and P-glycoprotein
vomiting. inhibitor.
Effects
posaconazole 100 mg Diarrhea, Contraindicated with Not used as a

Posanol BID po oral headache, cisapride, ergot alkaloids, first-line agent.
suspension nausea. pimozide, quinidine, May be
$$$$ after a sirolimus and statins. Avoid considered for
meal on concomitant administration resistant
the first with cimetidine, phenytoin cases.
day then and rifabutin. Posaconazole
100 mg is metabolized via UDP
once daily glucuronidation and is a
after a substrate for P-glycoprotein.
meal × 13 Therefore, inhibitors or
days inducers of these clearance
pathways may affect
posaconazole plasma
concentrations.
Posaconazole
concentrations are unlikely to
be altered by inhibitors of
CYP450 enzymes.
Posaconazole is a strong
inhibitor of CYP3A4; may
raise plasma levels of drugs
metabolized through this
enzyme pathway.
Drug Class: Antifungals, Polyenes
nystatin Swish & Diarrhea, GI No clinically significant drug Nystatin's

generics swallow irritation, interactions. GI absorption of relatively short
100 000– nausea, rash, nystatin is insignificant. contact time
$ 500 000 urticaria, with the oral
units QID vomiting. mucosa, high
po × 7–14 clearance from
days the oral cavity
and
requirement
for frequent
applications
potentially
limit its
usefulness.
a
Cost for specified duration of treatment; includes drug cost only.
Legend: $ <$100 $$ $100–200 $$$ $200–300 $$$$ $300–400
Suggested Readings
Pappas PG, Kauffman CA, Andes D et al. Clinical practice guidelines for the management of candidiasis:
2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009;48:503-35.
Pienaar ED, Young T, Holmes H. Interventions for the prevention and management of oropharyngeal
candidiasis associated with HIV infection in adults and children. Cochrane Database Syst Rev 2010;
Complementary and Alternative Therapies
Cynthia Richard, BScPh, PhD

Paul A. Spagnuolo, BSc, MSc PhD
CPhA acknowledges the contribution of Janet Webb as a previous author of this chapter.
Introduction
The promotion of wellness to prevent disease and enhance quality of life has engaged individuals in
proactive self-care. Greater public awareness about the importance of attaining and maintaining wellness
has been accompanied by a remarkable increase in the use of unconventional therapies in patient self-care.
These therapeutic approaches bring with them terminologies and philosophies that can be confusing to
those trained in the conventional medical sciences typically practised in North America. A vital step in better
understanding these approaches is recognition of the extent of use by Canadians, user demographics,
reasons for use and patterns of use, all of which continue to evolve. Appreciating the diversity of treatments
and the philosophies behind them, finding objective evidence to support or not support their use and the
efforts to integrate validated therapies into patient care are challenges facing Canada's healthcare
practitioners.
Definitions
Increased human mobility and improved global communication have led to increased awareness of and
exposure to previously unfamiliar therapies, and a greater exploration of these treatments by North
Americans. Use has surged in developed nations, where these treatments are better known as
complementary and alternative medicine (CAM).1 It is challenging to define the spectrum of CAM
approaches. As Western medicine becomes experienced with certain practices, the approaches become
standard treatment and are no longer considered complementary or alternative. The National Center for
Complementary and Integrative Health (NCCIH) in the United States defines CAM as a group of diverse
medical and healthcare systems, practices and products that are not generally considered part of
conventional medicine. Conventional medicine (also called Western or allopathic medicine) is medicine as
practiced by holders of M.D. (medical doctor) and D.O. (doctor of osteopathic medicine) degrees and by
allied health professionals, such as physical therapists, psychologists and registered nurses. The
boundaries between CAM and conventional medicine are not absolute, and specific CAM practices may
become widely accepted with time.2
Although the terms “complementary” and “alternative” medicine are often used interchangeably, they are
considered distinct.2 Alternative medicine is used in place of Western medicine (e.g., using herbs rather
than conventional pharmaceuticals to treat a condition), whereas complementary medicine is used in
combination with Western medicine. Integrative medicine combines conventional Western medicine and
those complementary treatments for which there is sound evidence of effectiveness and safety, but does
not replace conventional therapy (e.g., massage and guided imagery to ease pain).2,3
Prevalence
Although surveys of CAM use provide inconsistent findings because the definition of CAM varies (e.g., some
include prayer in the definition, some only include supplements), they can still be useful to identify trends
and patterns.4 A 2010 survey of Canadians on the use of natural health products (NHPs) found that 73% of
Canadians used NHPs (including vitamins).5 Between 1990 and 1997 in the United States, the use of herbal
products increased by 380% and high-dose vitamin use increased by 130%.6 A 2012 survey of Americans
revealed approximately 33% of adults and 12% of children had used CAM (excluding vitamins and minerals)
in the preceding 12 months.7,8 Dietary supplements (including fish oil, glucosamine/chondroitin, melatonin
and probiotics) were the most commonly used complementary health measures, followed by deep breathing
techniques. From 2002 to 2012, there was an increase in the use of yoga and tai chi in adults. A survey
performed in 2005 in the United Kingdom revealed that 29% of respondents taking prescription drugs had
used CAM in the preceding 12 months. The most commonly used therapies were massage, acupuncture,
aromatherapy and herbal medicine.9 General trends include higher prevalence rates of CAM in Western
regions, women, those with higher levels of education and income and, importantly, in those with chronic
conditions.7,8,10,11,12,13,14,15
Certain populations are more likely to use CAM therapies. Surveys undertaken in various regions of Canada
have demonstrated high use of CAM therapies by ethnic Chinese Canadians.16,17,18 First Nations
communities also maintain traditional healing practices as demonstrated by a study in Nova Scotia, which
found 66% of attendees to a clinic used Mi'kmaq medicine in addition to Western medicine, and of these
92.4% did not discuss this use with their physician.19
A survey of Canadians revealed that 12% of the general population visited a CAM practitioner in the previous
12 months. Percentages for patients with specific conditions were: 15% for asthma, 19% for migraine, and
8% for diabetes. Surveyors hypothesized that patients with adequate control of their disease were less likely
to seek alternatives.15 This theory is supported by an analysis of consultations with alternative healthcare
practitioners (massage therapy, acupuncture, homeopathic/naturopathic treatment) in Ontario. Women with
chronic conditions (fibromylagia, chronic fatigue, high blood pressure, and chemical sensitivities) were more
likely to seek a CAM provider if they felt their healthcare needs were not being met.20
It is estimated that 57–80% of cancer patients use one or more CAM interventions.21 The incidence of
lifetime use of a CAM product/therapy or visit to a CAM therapist was found to have increased in randomly
selected breast cancer survivors in Ontario from 67% in 1998 to 82% in 2005, with 41% of respondents in
2005 reporting use of CAM to manage their cancers.22 A survey examining the use of herbal remedies by
cancer patients in the United Kingdom found that usage increased with time since diagnosis.23 The use of
CAM by pediatric cancer patients since diagnosis was 20–60% in the majority of studies included in a
systematic review.24 Other studies have found similar CAM usage in Canadian pediatric patients in
cardiology and neurology clinics.25,26
Chronic, difficult-to-treat conditions prompt patients to seek alternatives, and those facing devastating
diseases turn to CAM when conventional treatments have been exhausted (although most patients with life-
threatening conditions do not use CAM exclusively).
Safety
Although Canadian consumers desire reliable information on CAM, they often base their choices on
potentially unreliable or unsubstantiated sources. While scientific evidence and advice from healthcare
practitioners affect their choices, patients give strong consideration to the treatment’s “naturalness”,
perceived lack of side effects, and advice from friends and family when deciding to use CAM
treatments.27,28 Claims by unscrupulous manufacturers and distributors can mislead and confuse
consumers with pseudoscientific jargon and rhetoric.29,30 In Canada, although NHPs require premarket
approval and evidence to support efficacy, safety and quality and must meet labelling standards, verbal
claims are often made by health food store personnel despite lack of supporting evidence.31 A lack of
knowledge of basic safety issues such as herb-drug interactions and contraindications increases the risks
of an adverse outcome when such personnel provide advice.32 Of additional concern is the lack of
accreditation or standards for some CAM practitioners in Canada.33
A 2010 survey of Canadians regarding NHPs demonstrated increasing public awareness regarding NHP
safety issues with physicians and pharmacists the most preferred NHP information sources.5 Nonetheless,
many Canadian consumers are reluctant to discuss NHP usage with conventional healthcare practitioners,
fearing lack of support in their decisions to choose NHPs and doubt regarding the consumer's values and
beliefs.34 It has been estimated that less than 1% of those who use NHPs disclose this information to their
pharmacist.35 Case reports have highlighted that using a stepwise approach to conducting a medication
history can identify NHP use and prevent unnecessary harm.36 This approach is recommended as part of
Best Possible Medication History (BPMH) guidelines.37
When assessing the safety of CAM therapies, in addition to potential harm caused directly by the therapies
themselves, practitioners must also consider indirect harm that may arise from choosing less effective CAM
treatments over conventional methods that have proven efficacy.38 For example, patients may choose a
CAM treatment over surgery and chemotherapy for cancer treatment, and this may contribute to disease
progression. Factors such as the severity and acuteness of the illness, safety and efficacy of the desired
CAM treatment, and toxicity associated with conventional treatment must be considered in the risk-benefit
analysis of CAM vs. conventional medical treatment.
Evidence
While there may be evidence to support certain CAM treatments, there is often a gap between published
randomized controlled trials (RCTs) finding CAM to be of little or no effect, and anecdotal reports of clinical
benefit by CAM practitioners and their patients.39 Pharmacists are well placed to discuss CAM options with
patients, especially NHP selection, but many feel ill equipped to provide reliable information based on sound
research.40,41 This leads to frustration at the pharmacy, as less than half of patients surveyed thought that
their pharmacist provided useful information about complementary therapies.42 In direct contrast to drug
therapy where research precedes marketing approval, a lack of regulatory oversight in CAM has seen these
therapies become embedded and diversified before clinical trials are conducted.31,39,40,43,44 For example,
an assessment of published RCTs of herbal interventions found quality of the reports to be unsatisfactory,
reinforcing the need for adoption of established reporting standards.45 The Consolidated Standards of
Reporting Trials (CONSORT) group has developed an Herbal Medicinal Intervention extension to their RCT
reporting guidelines, addressing factors such as naming of the products, details of product composition and
quality testing.46 Similar guidelines have been developed for reporting of acupuncture interventions and
nonpharmacologic treatment interventions.47,48
Mainstream medicine has historically overlooked, ignored or rejected CAM, citing lack of convincing
evidence, flawed methodology and bias in CAM research, but increasing use by patients demands greater
understanding by practitioners as well as better quality research. Many conventional medicine practitioners
claim that benefits from CAM treatment are due only to placebo effect; indeed, factors that may be part of
CAM such as the degree of individualization, time spent with the practitioner, and physical interventions
(such as acupuncture) are associated with a stronger placebo response.49,50 For health professionals to
adopt any evidence into clinical practice they must be aware of research results, be able to assess and
interpret research findings, then apply the evidence into clinical practice.51 Because CAM does not have a
tradition of reliance on double-blinded, randomized, controlled trials that inform modern evidence-based
medicine, there are obstacles to this approach, as there are with many nonpharmacologic treatment
interventions (see Table 1). Application of scientific research findings into clinical practice by both
conventional and CAM practitioners can be haphazard and inconsistent.60 Schools that teach CAM
therapies do not have a tradition of research or research infrastructure, so in certain areas of practice
(traditional Chinese medicine) investigators are not familiar enough with clinical trial methodology to
perform research that satisfies Western reviewers.
Developing an evidence base for CAM therapies is a well-recognized challenge being addressed
internationally. To promote standards of practice in CAM, the World Health Organization has developed
training benchmarks to ensure practitioners have adequate knowledge, skills and awareness of appropriate
usage and safety in a variety of CAM practices, including traditional Chinese medicine, Ayurveda,
naturopathy, osteopathy and others.61 Additionally, the Cochrane group involved in CAM is distributing
guidelines on trial design and reporting standards to CAM practitioners, with a particular focus on traditional
Chinese medicine.58 The NCCIH within the National Institutes of Health has invested US $2 billion to
support CAM research.51 Education programs are underway both to educate CAM practitioners on clinical
research methodology58 and to introduce conventional healthcare practitioners to CAM, to promote open
dialogue with patients.62,63 A recent survey of Canadian regulated CAM schools (including schools of
chiropractic, naturopathy, massage therapy and acupuncture) indicated that research methods and
evidence-based healthcare training were offered by 81% and 91% of the schools respectively.64 In addition,
suggested core competencies in pharmacy students include the ability to access and critically appraise
sources of information related to NHPs and the ability to educate patients on the safety and effectiveness of
NHPs.65
Despite the challenges, high-quality RCTs in CAM can be designed66 and do exist.59 In Canada, collaborative
projects to gather CAM evidence include the Canadian Institute of Natural and Integrative Medicine
(www.cinim.org), and IN-CAM (the Canadian Interdisciplinary Network for Complementary and Alternative
Medicine Research) (www.incamresearch.ca). IN-CAM also provides high-quality reviews of CAM therapies
and natural health products. Systematic reviews are being used to gather and synthesize evidence and to
identify potential areas of research. Cochrane Complementary Medicine is a group dedicated to producing
and disseminating systematic reviews of RCTs in numerous CAM areas (acupuncture, massage,
chiropractic, homeopathy, herbal medicine, mind-body therapy). Although not without challenges
(considering the heterogeneity of CAM therapies), nearly 800 systematic reviews involving CAM were listed
in the Cochrane Library in 2015. Cochrane reviews of CAM treatments for specific conditions are made
readily available as plain language summaries.67
Table 1: Challenges with Research Involving CAM
Locating published evidence44,52,53,54

lack of consistent CAM terminology and indexing headings
publication bias in high-impact journals
foreign language
journal reviewers may be unfamiliar with CAM methods
many CAM journals are not included in conventional databases (PubMed)
Methodology and research design issues39,43,44,55,56,57,58,59

heterogeneity of products and practices
lack of standardization of biologic products hampers reproducibility
individualization of treatment approaches makes effects of treatment difficult to
measure
difficulties with blinding (e.g., acupuncture)
expectation bias and placebo effect
lack of appropriate animal models for some areas of CAM, such as those involving
nonpharmacologic treatment interventions
lack of funding for large CAM trials
Integrative Medicine
Integrative initiatives are fostering closer collaboration between conventional and CAM practitioners, to
deliver a more comprehensive approach to patient care. Integration can occur on different levels—as
individual practitioners combine therapies (e.g., physicians performing acupuncture), or in integrative clinics
and institutions where conventional and CAM practitioners work together.68 Collaboration and
communication between conventional and CAM practitioners will improve monitoring of adverse effects,
identify potential therapeutic benefits of an integrative approach, and foster progress through research.69
Additionally, working in a collaborative integrated environment positively affects job satisfaction and
personal growth of Canadian practitioners.70 In Alberta, the CAM in UME Project (Complementary and
Alternative Medicine Issues in Undergraduate Medical Education) is a medical education initiative to
facilitate educating undergraduate medical education students about issues related to patients’ use of CAM
(www.caminume.ca). The project does not teach medical students to practice complementary therapy, but
to be prepared to practice medicine in an environment where CAM may be used by their patients in
combination with conventional treatments.63 Other Canadian examples of initiatives to promote integrative
medicine include CARE (Complementary and Alternative Research and Education), which is an academic
pediatric integrative medicine program at the University of Alberta (www.CARE.ualberta.ca), and
InspireHealth, an integrative cancer care program with several centres in British Columbia
(www.inspirehealth.ca).
With the increasing use of CAM therapies, and the integration into mainstream medical practice, healthcare
practitioners must become familiar with relevant terminology. The following provides definitions and brief
descriptions of categories of CAM and therapeutic modalities that healthcare practitioners may encounter in
this evolving area.
Categories of CAM
The National Center for Complementary and Integrative Health in the United States groups CAM therapies
into 5 major categories (see also Table 2 and Table 3).
Alternative Medical Systems2
These are complex and comprehensive systems of treatment, encompassing both theory and practice,
which have developed outside the sphere of conventional medicine. Some have been in use for thousands
of years (e.g., traditional Chinese medicine) while others have been developed more recently (e.g.,
homeopathy). These include traditional Chinese medicine, Ayurveda, homeopathy and naturopathic
medicine (see Definition of Therapeutic Modalities).
Mind-body Interventions2,72,73,74
These therapies utilize the brain or mind to influence body function (see Table 2). The concept that the mind
can influence illness is integral in the healing approaches of traditional Chinese and Ayurvedic medical
systems.71 Evidence from RCTs and systematic reviews suggest a connection between the nervous system
and other body systems (e.g., the immune, autonomic and endocrine systems), which may be activated to
promote self-healing and well-being. Observed positive psychological effects and enhanced quality of life
may be of particular use for individuals with chronic conditions and in need of palliative care. The
connection between the mind and body has been explored in the use of support groups for cancer patients
(now considered mainstream therapy) and in the effect of exercise on altered mood (e.g., increased
endorphins to combat depression). In pediatrics, hypnosis, guided imagery and biofeedback have been used
effectively to manage pain, anxiety, stress and sleep disorders.59 Mind-body interventions are considered
low risk.
Natural Product–Based Therapies2,75
Also known as biologically-based practices, this describes the use of natural/biologic products, which can
be derived from plants (e.g., herbs) or animals (e.g., shark cartilage), and also includes vitamins, minerals,
fatty acids, amino acids, proteins, prebiotics, probiotics, whole diets and functional foods (see Table 2).
Orthomolecular and megavitamin therapies are in this category.
Manipulative and Body-based Methods2,76,77,78
These manual therapies (e.g., chiropractic and massage therapy) involve manipulation or movement of the
body (see Table 2). Some methods propose that bodily function depends on proper body alignment, and that
misalignment or asymmetry results in illness, possibly at a site distant from the distortion. Correction of
body symmetry optimizes the balance between the sensory and motor nervous systems.76 Restoration of
structural imbalance to improve blood and lymph flow is one of the proposed mechanisms by which these
therapies facilitate the body's ability to heal itself.76
Energy Therapies2
These methods seek to manipulate energy fields (biofields) within or surrounding the body (see Table 2). In
traditional Chinese Medicine this is referred to as qi (pronounced “chee”) which is the vital life force that
circulates through the body in invisible pathways termed “meridians”. In Ayurveda these life forces are
referred to as doshas. The underlying theory maintains that the universe is permeated with a “life force” or
“vital energy” that also surrounds and pervades the human body.79 Imbalance or blockages of the energy
may result in disease, and therapy is aimed at correcting these problems. For treatment of a condition, a
close, cooperative participation between the practitioner and the patient is required. Therapeutic touch, reiki
and qigong are examples of energy therapies.
2,71
Table 2: Major Groupings of Selected Common CAM Approaches
CAM Category Examples
Alternative medical systems Ayurvedic medicine

Traditional Chinese medicine
Homeopathy
Naturopathy
Japanese traditional medicine
Tibetan traditional medicine
Mind-body interventions Aromatherapy

Biofeedback
Hypnosis
Imagery
Relaxation techniques
Meditation
Tai chi
Yoga
Natural product–based therapies Herbalism

Nutrition therapy (includes diet therapy, dietary
supplements)
Hydrotherapy
Manipulative and body-based methods Chiropractic manipulation

Craniosacral massage
Massage
Osteopathic manipulation
Reflexology
Rolfing
Tui Na
Energy therapies Acupuncture, Acupressure, Moxibustion

Magnetic therapy
Qigong
Reiki
Therapeutic touch
2,71
Table 3: Examples of Delivery Methods for CAM
CAM Delivery Method Examples
Treatments primarily self-administered Herbal remedies

Nutritional supplements
Health foods
Meditation
Magnetic therapy
Treatments administered by provider Acupuncture

Massage therapy
Reflexology
Chiropractic manipulation
Osteopathic manipulation
Treatments self-administered under Ayurveda

periodic supervision or guidance by Biofeedback
provider
Homeopathy
Hydrotherapy
Nutritional therapy
Tai chi
Definition of Therapeutic Modalities
Acupressure
Acupressure is a manual therapy that applies deep pressure to certain acupuncture points.76,80 It is
theorized that different noxious stimuli, including emotional trauma, cause energy to accumulate in
particular pressure points situated along the channels or meridians through which qi flows. Application
of pressure by the practitioner improves flow of qi, causing a release and dissipation of tension,
alleviation of disease and relief of pain.76 It has been studied for the treatment of nausea of pregnancy,
headache, backache, stroke, pain associated with chemotherapy and traumatic brain injury.80,81
Application of pressure to a particular point on the inside of the wrist has been promoted to alleviate
motion sickness, however there is limited evidence to support its efficacy.82
Acupuncture
Acupuncture can describe either a therapeutic discipline or a technique, which can vary with different
traditional approaches and is now practiced by both conventional and CAM practitioners.83 Needles of
various sizes, but commonly having a shaft of 25 mm and a diameter of 0.25 mm, are inserted at
specific points on the body to regulate the flow of qi along chosen meridians.84,85 In a more
conventional approach, these acupuncture points are termed “trigger points,” which correspond to areas
of increased sensitivity that can produce referred pain in a characteristic manner.86 Anatomically, these
points often correspond to peripheral nerve junctions and may be involved in pain transmission. The
technique itself involves the insertion of several needles (usually 4–10), and may vary with respect to
angle and depth of insertion, length of time retained (often 10–30 minutes), manipulation methods (e.g.,
twirling, electrical current) and frequency of treatment.86 Variations on needle therapy include Shiatsu,
moxibustion, acupressure and electric currents. Areas of interest in acupuncture treatment include pain
management, including postoperative dental pain, headache, substance abuse, nausea, asthma, urticaria
and stroke rehabilitation.81,86,87,88,89 Neural pathways, neurotransmitters and hormonal factors are
believed to be affected by acupuncture.90 Research supports the use of acupuncture in pain secondary
to temporomandibular dysfunction, fibromyalgia, osteoarthritis, low back pain and idiopathic
headache,91,92 including recurrent headache in children.21,59 Systematic reviews have concluded
acupuncture is an option for chronic pain,93 migraine prophylaxis94 and tension-type headache.95
Applied Kinesiology
This diagnostic technique used by chiropractors and other practitioners is distinct from kinesiology, and
uses acupressure points and muscle strength testing to identify health and nutritional problems.75,96
Practitioners assert that weakness in particular muscles corresponds to specific illnesses or
deficiencies which can be corrected by manipulation or supplements.
Aromatherapy
Aromatherapy is a treatment method using volatile (essential) oils derived from plants whose fragrance
or odour is deemed an integral part of therapy.97 The oils are extracted from plants, diluted with
vegetable oil then often applied to the skin by massage, or they can be delivered in steam for inhalation
of the scent.80 When applied externally, the fragrance, the massage itself and the dermal absorption of
the constituents are all deemed beneficial,98 although a psychological component cannot be ruled out.72
In the United Kingdom, aromatherapy has been used in conventional settings such as hospices, palliative
care units, cancer units and pediatric units.97
Ayurveda
Ayurveda is a major medical system that originated in India and possibly dates back as much as 5000
years.2,80,99,100 It is a complex system of theory and practice, which considers the body, mind and spirit,
and attempts to achieve harmony and balance between them. It is believed that the body is a miniature
representation of the universe. The same elements that form the universe form the human body; when
the elements are out of balance (i.e., imbalance within the body or between the body and the
environment), ill health results. Patient assessment includes physical examination as well as
consideration of mental and social factors. Treatment choices include manipulation, diet, yoga,
meditation, purification to rid the body of toxins (possibly involving vomiting, purgation or enemas) and
rejuvenation therapies to build the body's strength. Herbal therapies are employed, as well as minerals
and metals, which might include heavy metals. As with other herbal therapies, the safety of Ayurvedic
herbs may be questionable as lead poisoning has occurred following the use of Ayurvedic remedies
brought into Canada.101
Biofeedback
Biofeedback is a system that permits a patient to regulate body function (e.g., heart rate, blood pressure,
degree of muscle contraction) by receiving feedback signals from instruments monitoring a particular
physiological function (e.g., brain waves), and to adjust the physiologic process accordingly.80 It may be
effective for varied conditions including irritable bowel, bladder disorders, asthma, headache, post-
traumatic stress disorder, cardiac arrhythmias and hypertension.75,96
Chinese Herbal Medicine
Chinese herbal medicine is an integral part of Chinese medicine, which encompasses use of animal
parts and minerals in addition to plant material.84,102 Substances can be categorized according to their
properties, which include heat clearing, wind dispelling or blood rectifying. The use of medicinal
substances can be complex, with specific combinations selected based on their compatibility and
complementary/synergistic effects.103 Typical combinations contain 2–40 herbs in differing amounts,
and the combination will be adjusted during the course of treatment according to the clinical
presentation.102 They are usually consumed as a decoction (simmered tea) but also may be dispensed
in solid dosage forms or used externally. Be aware that some imported herbal products may contain
contaminants or be otherwise adulterated.
Chiropractic
Chiropractic is a body-manipulation therapy aimed at correcting misalignment within the

musculoskeletal system.78 Chiropractors apply a variety of manoeuvres, such as sharp thrusts, to the
spine, pelvis and limbs in order to adjust alignment and correct disorders.104 Although formerly
advocated for treating a wide variety of complaints, today it is limited primarily to treating
musculoskeletal disorders. There is evidence for its use in acute low back pain and in tension-type and
migraine headache.78,96 While rare, stroke or vertebral artery dissection have followed manipulation of
the neck, although causation has not been established.78
Craniosacral Therapy
Craniosacral therapy is a manual technique in which gentle pressure is applied to the skull to adjust and
normalize rhythmic pulsations of the cerebrospinal fluid.105,106 It has been purported to relieve pain
(e.g., headache) and vertigo.
Cupping and Bleeding
This is a component of Chinese medicine in which a warm glass or bamboo cup is placed on the skin. As
it cools, the suction created draws blood and lymph to the skin surface. It is used to assist circulation
and to remove “cold and damp” which are considered external causes of disease.84,105 Arab healers
believed that cupping would relieve a variety of ailments, from toothache to elephantiasis.85
Dietary Supplements
This term has various interpretations. In the United States it is defined by the Dietary Supplement Health
and Education Act (1994) as a product intended to supplement the diet which may contain one or more
dietary ingredients including vitamins, minerals, amino acids, herbs or other botanicals and other
substances.107 It is an oral dosage form (pill, tablet, capsule or liquid) and must be labelled as a dietary
supplement. Its intended use is to resolve a nutritional deficiency or to improve or sustain the function of
the body. If used to diagnose, prevent, treat or cure a disease it is considered a drug, and not a dietary
supplement. The Act does not require proof of efficacy or safety or standardization.107 The accepted
regulatory term in Canada is Natural Health Product (NHP), which is defined differently (see Natural
Health Products).
Functional Foods
According to Health Canada, “a functional food is similar in appearance to, or may be, a conventional
food, is consumed as part of a usual diet and is demonstrated to have physiological benefits and/or
reduce the risk of chronic disease beyond basic nutritional functions”.108 Functional foods are
developed through various means, including fortification with vitamins and/or minerals beyond
mandatory requirements, addition of bioactive ingredients, and enhancement of bioactive components
through processes such as plant breeding and special livestock feeding.109 Examples of foods that are
thought to have benefit by supplying biologically active ingredients are eggs enriched with omega-3 fatty
acids, cereals containing oat bran and tomatoes rich in lycopene.110 Exemptions in the Food and Drugs
Regulations have allowed some functional foods to carry health claims; for example, margarines
containing plant sterols may claim to reduce cholesterol on their labels.111
Functional Medicine
Functional medicine is a patient-centred care model that integrates conventional and CAM practices, and
considers the interplay between environment, lifestyle, genetic and mind-body factors, and their influence
on the health of an individual. Nutrition, diet and exercise are strategies emphasized in disease
prevention; conventional diagnostic and treatment methods are combined as necessary with CAM
therapies in treatment.112
Herbalism
Herbalism is an approach that uses plant-based medicines as substitutes for pharmaceuticals, and as
vehicles to optimize health and wellness. The WHO has taken the position that, in the absence of
opposing scientific evidence, the traditional and historical use of herbal remedies provides evidence of
their efficacy and safety;113,114 they also published a document to guide quality control in herbal
medicines.115 Medical herbalism has been a sustained therapeutic approach in numerous countries,
including Western nations such as Germany where modern pharmacology and herbalism successfully
coexist.1 The entire plant kingdom, including moss, algae and fungi may be utilized (although some
herbal traditions also use animal parts, insects, metals, rocks or shells).116 The basis of herbalism is the
belief that the physiological response to a plant will be different than the response to an individual
chemical component of the plant.105 Growing conditions and collection and storage methods will also
affect response, as will the expectations of the patient and the cultural significance of the plant (which
may contribute to increased placebo response).
Holistic Medicine
This is an approach that takes into account the body, mind and spirit of an individual, as well as their
interaction, to maintain health and well-being.105,117 Some argue that competent physicians have always
done this, and that it is not the exclusive domain of CAM practitioners.3 What might be termed a holistic
approach, the practice of involving multidisciplinary teams (physicians, spiritual healers and
psychological counsellors) has been successfully incorporated into conventional medical
practices.118,119
Homeopathy
Homeopathy is an alternative medical system, dating back to the early nineteenth century, based on the
philosophy that the body has an innate ability to heal itself, and that “like cures like”.77,83,120,121 It
teaches that symptoms are manifested when the body attempts to heal itself or to correct an imbalance.
The presenting symptoms guide therapy. The premise is that a substance that produces a specific
pattern of symptoms in a healthy person will, when given in homeopathic doses, help fight an illness with
identical symptomatology. Homeopathic remedies are chosen based on the mental and emotional state
of the patient, in addition to the physical. Therapies are highly individualized and, in general, should be
made only by a trained homeopath. The closest match between the symptoms of the individual and the
remedy is attempted, recognizing that different people will exhibit different symptom patterns. There are
more than 2000 homeopathic substances, which are derived from plants, minerals, metals, animal
products and even diseased tissues. The substances are prepared in serial dilutions, which are
vigorously shaken with each dilution, which is believed to increase potency. Potencies are typically noted
as X or C, indicating 1:10 dilutions, or 1:100 dilutions, respectively (e.g., 6X will denote 6 dilutions of
1:10). The goal of the dilution process is that no molecules of the original substance exist in the final
preparation. Paradoxically, the greater the dilution, the higher the potency. Preparations of highest
potency are reserved for use under the direction of a homeopath. In North America, asthma, headache,
depression, allergies, psychosocial problems and skin conditions are among the most frequent
conditions treated by homeopaths. In the United Kingdom, homeopathy is often used in children to treat
minor self-limiting conditions.122 Homeopathic medicines are regulated as natural health products in
Canada, and authorized products are identified by an eight-digit Homeopathic Medicine Number (DIN-
HM).123 The WHO has developed a document addressing safety issues in homeopathic remedies.124
Hydrotherapy
Hydrotherapy includes a multitude of diverse applications including baths, saunas, douches, immersion,
wraps and colonic irrigation, where water is used as the main tool of the therapeutic intervention.85,125
Hypnotherapy
Hypnotherapy is used to induce a state of relaxation by selective attentional focusing using imagery or
distraction, where intrusive thoughts can be ignored.21,75,126 It includes a suggestive component where
therapeutic goals can be introduced (e.g., a pain-free state). It is possible to maintain the behaviour once
the hypnotic state has been terminated. Muscle relaxation, altered perception and cognitive distraction
are possible mechanisms.126 It has been used with some success in smoking cessation and has been
found useful in coping with pain, distress and anxiety in children with cancer undergoing bone marrow
aspiration.21
Imagery
Imagery involves the use of directed mental images to promote changes in attitudes or behaviour, relieve
symptoms or to encourage physical healing. The process may be guided by a practitioner or patients can
be instructed in its application. It is often used for alleviation of stress and its sequelae including
insomnia. It is thought to reduce the need for the use of analgesics in cancer patients.21
Iridology
Iridology is a discredited method of diagnosis which examines changes in the iris to determine state of
health.72,80
Magnet Therapy
Magnet therapy involves the application of magnets to treat disorders by influencing ionic currents in the
body causing stimulation of cells and enhanced blood flow.55,106 It is not to be confused with magnetic
healing, which was a form of hypnosis. Unipolar or bipolar magnets are fastened into clothing, worn like
jewelry (e.g., bracelets), held in place against the skin by adhesive or used in bedding. They have been
promoted to treat musculoskeletal complaints such as chronic low back pain, muscle pain in postpolio
syndrome and neuropathic pain in diabetes, although a systematic review did not support their use for
pain relief.55
Massage Therapy
Massage therapy is a manipulative method that uses a variety of manual techniques (stroking, kneading,
friction, vibration) applied to soft tissues.76,78 Human touch itself is considered to be a beneficial part of
massage. It is used in traditional medical systems including Ayurveda and Chinese medicine. Massage
is used to promote relaxation, relieve muscle tightness, alleviate pain, reduce anxiety and promote sleep.
It is used to promote the growth and development of premature infants59 and might benefit patients
suffering from anxiety and chronic cancer pain.21 It should not be used in patients with deep vein
thrombosis, advanced osteoporosis, fractures or where skin is compromised.78
Meditation
Meditation is one of the most commonly used mind-body interventions to induce relaxation and a sense
of calm.96 It is a self-directed practice that involves a conscious mental process of becoming aware of
one's thoughts and achieving mastery over them. It is becoming increasingly recommended in Western
conventional medicine as it has been shown to reduce symptoms of anxiety.127 Functional magnetic
resonance imaging has shown that meditation can activate areas of the brain involved in attention and in
the control of the autonomic nervous system. It is an element of different traditional medical systems
including Chinese medicine and Ayurveda as a component of yoga, qigong and tai chi. Preliminary
evidence has found that some meditation techniques alter blood flow in the brain, lower blood pressure,
slow respiratory rate, improve immune function, help with coping strategies and provide a positive
emotional state.75,96,126
Moxibustion
Moxibustion is a component of Chinese medicine that involves the burning of dried and powdered leaves
of Artemesia vulgaris.84 It can be burned in very small amounts directly on the skin, on a mediating
substance placed between the burning material and the skin surface or on the handle of an acupuncture
needle. It is believed that the burning substance has the ability to enter the meridians and affect the flow
of qi. Moxibustion is used in combination with acupuncture for a wide variety of conditions.
Natural health products (NHPs) have been regulated in Canada since 2004.123 According to Health
Canada, the definition of a natural health product includes both function and substance.128 Function
captures substances for use in the diagnosis, treatment, mitigation or prevention of disease/disorder;
restoring, correcting or modifying organic functions in a manner which maintains or promotes health.
Acceptable substances include materials derived from plants, algae, bacteria, fungi and non-human
animals; these include vitamins and minerals, herbal remedies, homeopathic medicines, traditional
medicines like traditional Chinese medicines, probiotics, and other products like amino acids and
essential fatty acids. Numerous exclusions are listed such as antibiotics, blood products, tobacco,
injectables, biologics, cannabis and others. Natural health products must be safe for use as patient self-
selected products and are available for purchase without the consultation of a healthcare practitioner.
Premarket authorization is required for sale. Manufacturers must provide evidence that products are
safe, effective and of high quality before obtaining a product license, although the type of evidence
varies depending on whether the product has a traditional use claim (supported by traditional evidence)
or a modern use claim (typically supported by randomized controlled trials).128,129,130
Contamination is a frequent problem with imported NHPs due to lack of rigorous manufacturing
standards. In particular, many Chinese herbal products are the subject of Health Canada warnings for
containing undeclared medications, bacteria and fungi; most of these are not authorized for sale in
Canada.131,132,133 Practitioners should be reminded to recommend only natural health products that are
authorized for sale in Canada, as indicated by a Natural Product Number (NPN), Homeopathic Medicine
Number (DIN-HM), or Exemption Number (EN).
Naturopathic Medicine
Naturopathic medicine is a system of treatment, defined by a broad scope of practice, that emphasizes
the healing power of nature, and which draws from a wide variety of therapeutic approaches.125,134,135
The use of nutrition, herbs and natural products is fundamental, with treatments borrowed from Chinese
medicine, homeopathy, herbalism, Ayurveda and manual therapies. As it does not identify with one
particular mode of therapy, it is generally defined by its approach. This includes core principles of
preventive medicine, treatment of the whole person and determination of the cause of the disease.
Treatment combinations are individualized for each patient, in an effort to aid self-healing and restore
normal body function, rather than attempt to focus on the treatment of symptoms. Interventions include
natural products, nutritional counselling, acupuncture, naturopathic manipulation, traditional Chinese
medicine, homeopathy and many others.135
Nutraceutical
Health Canada defines a nutraceutical as “a product isolated or purified from foods that is generally sold
in medicinal forms not usually associated with food. A nutraceutical is demonstrated to have a
physiological benefit or provide protection against chronic disease”.108 From a legal standpoint, these
products are regulated as natural health products in Canada. The concentrated dosage forms can deliver
ingredients in amounts exceeding those found in food.29 Examples include omega-3 fatty acids derived
from marine sources and isoflavones isolated from soy, sold in capsule form.
Orthomolecular Therapy
Orthomolecular therapy is a term derived from the Greek word “orthos,” meaning straight or correct, and
was first used by Linus Pauling in 1968 to describe the treatment of disease with large quantities of
nutrients, especially vitamins.80 It is similar to megavitamin therapy but minerals, amino acids,
hormones and metabolic intermediates can also be administered. The amounts of nutrients
administered may be 20–600 times the recommended daily intake.
Osteopathic Medicine
Osteopathic medicine is a system that originated as a manipulative method, but has evolved into
mainstream medicine in the United States where practitioners receive a Doctor of Osteopathy (DO)
degree and restrict themselves to conventional medicine.76,104,136 Underlying principles are based on an
appreciation of the connection between the body's tissues, fluids and systems; treatment is aimed at
restoring integrity of structures and improving interactions of the body's systems. Osteopaths perform
various practices which include manual techniques that combine manipulation and massage therapy,
such as thrusting (similar to chiropractic methods) and lymphatic drainage and craniosacral therapy
(similar to massage therapy). Osteopathic methods attempt to correct symmetry, motion restriction,
tissue texture changes and tenderness. In countries other than the United States, such as Great Britain,
osteopaths earn Bachelor of Science degrees and have practices similar to that of chiropractors.
Qigong
Qigong is an energy therapy that is a major branch of Chinese medicine and is aimed at manipulating
qi.84 It involves a wide variety of activities to balance, regulate and harness qi in order to promote health,
longevity, healing and spiritual development. An internal form has the patient acting alone using exercise,
breathing or relaxation methods. In the external form, a practitioner projects his or her qi into the patient
via their hands, the use of needles or visualization. In healthy volunteers, it has been shown to reduce
cortisol levels, and might be of use to relieve stress.126 Other potential benefits include hypertension and
respiratory disease.75 Qigong may also improve quality of life for cancer patients.137
Reflexology (Zone Therapy)
Reflexology is a manual technique in which the practitioner applies deep pressure using their fingers and
thumbs on the patient’s feet.76,98 Different zones on the feet are thought to correspond to areas on the
body (equated with meridians) and application of pressure is thought to enhance the flow of energy in
the body. Reflexology has been applied for the relief of symptoms associated with chronic conditions
such as asthma, headache, and bladder or bowel problems, and to patients suffering stroke, brain injury
or spinal cord injury.81
Reiki
Reiki is an energy therapy developed in the mid-nineteenth century whereby practitioners channel the
universal life energy (i.e., reiki) through meditation and prayer from their own body to the patient's, to
promote healing.76,79 Reiki has been used in the treatment of fibromyalgia, pain, cancer and depression,
as well as for overall well-being, but research has not confirmed usefulness for any condition.138
Relaxation
Relaxation employs various techniques, approaches and modes of practice.75,96 Most involve repetitive
action (focus on a word, sound, phrase, muscular activity), and adopting a passive attitude toward
intruding thoughts with a return to focus. It has been studied in anxiety, depression, pain and irritable
bowel syndrome.96
Rolfing
Rolfing is a manipulation method that uses deep muscle massage to correct distortions in the body.76,79
It teaches that distortions in posture reflect a withdrawal response to past emotional and physical
trauma, and restoring correct posture with manipulation will release the traumas, resulting in a feeling of
lightness and well-being.
Shiatsu
Shiatsu is a Japanese massage technique in which pressure is applied to specific points on the body
likened to acupuncture points.76,80,139 It may be combined with passive stretching to optimize the
effect. It has been likened to acupressure in technique, but is used more for prevention of illness than
treatment.
Tai chi
Tai chi is a series of precise, focused slow-moving postures accompanied by controlled breathing and a
calm, relaxed mind, which involves physical and mental discipline.126 It is used to unite body and mind
and promote balance in life. Limited evidence demonstrates a lowering of blood pressure and heart rate
and a reduction in stress. Tai chi may be useful in osteoarthritis of the knee,140 prevention of falls in the
elderly,141 and improving balance in patients with mild to moderate Parkinson's disease.142
Therapeutic Touch
Therapeutic touch is an energy therapy developed in the late 1960s in which providers move their hands
above the surface of a patient's body in an attempt to correct imbalance in the patient's energy field and
facilitate healing.76,80,143 Practitioners believe that their hands can transfer energy from themselves to a
patient to achieve energy balance within the patient. It is a popular treatment for pain, anxiety,
Alzheimer's dementia and stress; therapeutic touch is also used to improve well-being of cancer
patients.96
Traditional Chinese Medicine
Traditional Chinese medicine, also known as traditional Oriental medicine, is a comprehensive and major
medical system, dating back to 3000 BC, which comprises many traditions, philosophies and
approaches to treatment.77,80,83,102,144 It is based on fundamental concepts that include a balance
between yin and yang (opposing yet complementary phenomena that exist simultaneously throughout
the universe and the body) and unimpeded flow of qi (the vital force or energy which circulates through
the body in invisible pathways termed “meridians”). Health problems may reflect a lack of harmony
within an individual, or between individuals and their environment, resulting in a blockage in the flow of qi
and an imbalance of yin and yang. Diagnosis of the patient involves a multitude of techniques in addition
to taking a medical history, which include assessing temperament, examining the tongue and properties
of the pulse and noting qualities of speech and breath. The practitioner evaluates how illness manifests
itself in the patient, and then treats the person, not the disease. Treatments are highly individualized, and
employ various methods, to target the deep cause of the disease rather than only symptoms.102 Chosen
methods of therapy include diet, herbal therapy, acupuncture, moxibustion, cupping and bleeding, tui na
and qigong.
Traditional Medicine
The WHO defines traditional medicine as “the sum total of the knowledge, skills, and practices based on
the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in
the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical
and mental illness”.145
Tui Na
Tui Na is a manipulative practice within Chinese medicine, which involves trained practitioners
manipulating soft tissues and joints.76,84 Attention is given to the flow of qi along meridians, and
acupuncture points are stimulated. It is commonly used in orthopedic and neurological applications, and
can be used in situations where acupuncture is considered inappropriate (e.g., pediatrics).
Yoga
Yoga is one of the top CAM modalities used in North America and is intended to promote relaxation and
achieve balance in mind, body and spirit through the use of physical postures, breathing exercises,
meditation and a philosophical approach.96,146 The numerous schools of yoga incorporate these
components in varying proportions.75,96,146 Possible benefits include rejuvenation, awareness, self-
realization, stress reduction, increased strength and improved flexibility. It is advocated as a way to
increase the mind's flexibility and resilience when faced with stress. Limited research suggests yoga
may help with various conditions including asthma,96 hypertension,96 depression,147 pain148 and
anxiety; and it may also improve overall fitness, strength and flexibility.146 It should be noted that
individuals with certain medical conditions (glaucoma, hypertension, severe osteoporosis) could be at
risk with some postures.
Summary
Increasing focus on self-care has led patients to explore CAM therapies as means of improving their health
and well-being. As primary healthcare practitioners, pharmacists are at the forefront and are often the most
trusted practitioners when it comes to consulting on CAM modalities. Understanding the nature of CAM, the
history and terminology, and the potential benefits and limitations, will improve the pharmacist-patient
relationship and can significantly improve the health of the patient. While, in general, there is limited
scientific evidence to support the use of CAM modalities to improve disease outcome, there is evidence to
suggest their utility in improving health quality. It is important for pharmacists to be aware patients are
participating in these practices and to engage patients to better understand the nature of their CAM
practices. This open-minded approach will enable a more comprehensive approach to the patient's overall
health.
Resource Tips
Arthritis Research UK. Complementary and alternative medicines for the treatment of rheumatoid arthritis,
osteoarthritis and fibromyalgia. Available from: www.arthritisresearchuk.org/arthritis-
information/complementary-and-alternative-medicines/complementary-and-alternative-medicines.aspx.
Arthritis Research UK. Practitioner-based complementary and alternative therapies for the treatment of
rheumatoid arthritis, osteoarthritis, fibromyalgia and low back pain. Available from:
www.arthritisresearchuk.org/arthritis-information/complementary-and-alternative-
medicines/complementary-and-alternative-therapies.aspx.
Suggested Readings
Deng GE, Frenkel M, Cohen L et al. Evidence-based clinical practice guidelines for integrative oncology:
complementary therapies and botanicals. J Soc Integr Oncol 2009;7:85-120.
Kemper KJ, Vohra S, Walls R et al. American Academy of Pediatrics. The use of complementary and
alternative medicine in pediatrics. Pediatrics 2008;122:1374-86.
Monti DA, Sufian M, Peterson C. Potential role of mind-body therapies in cancer survivorship. Cancer
2008;112:2607-16.
Rogovik AL, Vohra S, Goldman RD. Safety considerations and potential interactions of vitamins: should
vitamins be considered drugs? Ann Pharmcother 2010;44:311-24.
Siow YL, Gong Y, Au-Yeung KK et al. Emerging issues in traditional Chinese medicine. Can J Physiol
Pharmacol 2005;83:321-34.
Tachjian A, Maria V, Jahangir A. Use of herbal products and potential interactions in patients with
cardiovascular diseases. J Am Coll Cardiol 2010:55:515-25.
Vogel JH, Bolling SF, Costello RB et al. Integrating complementary medicine into cardiovascular medicine. A
report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus
Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and
Integrative Medicine). J Am Coll Cardiol 2005;46:184-221.
References
1. WHO Congress on Traditional Medicine and the Beijing Declaration. WHO Drug Info 2009;23:8-11.
2. National Center for Complementary and Integrative Health. Complementary, alternative, or integrative
health: what’s in a name? Bethesda: NCCIH, National Institutes of Health. Available from:
nccih.nih.gov/health/integrative-health. Accessed April 21, 2016.
3. Ernst E. Disentangling integrative medicine. Mayo Clin Proc 2004;79:565-6.
4. Barnes PM, Powell-Griner E, McFann K et al. Complementary and alternative medicine use among
adults: United States, 2002. Adv Data 2004;343:1-19.
5. Health Canada. Ipsos-Reid. Natural health product tracking survey—2010 final report. January 2011.
Available from: www.hc-sc.gc.ca/dhp-mps/prodnatur/index-eng.php. Accessed April 21, 2016.
6. Eisenberg DM, Davis RB, Ettner SL et al. Trends in alternative medicine use in the United States,
1990-1997: results of a follow-up national survey. JAMA 1998;280:1569-75.
7. Clarke TC, Black LI, Stussman BJ et al. Trends in the use of complementary health approaches
among adults: United States, 2002-2012. Natl Health Stat Report 2015;79:1-16.
8. Black LI, Clarke TC, Barnes PM et al. Use of complementary health approaches among children aged
4-17 years in the United States: National Health Interview Survey, 2007-2012. Natl Health Stat Report
2015;78:1-19.
9. Hunt KJ, Coelho HF, Wider B et al. Complementary and alternative medicine use in England: results
from a national survey. Int J Clin Pract 2010;64:1496-502.
10. Park J. Health reports: use of alternative health care, 2003. Ottawa: Statistics Canada. The Daily
2005 Mar 15. Available from: www.statcan.gc.ca/daily-quotidien/050315/dq050315-eng-htm.
Home Testing

Introduction
Home diagnostic devices are used for early diagnosis, to determine whether a certain therapy is effective, to
monitor a medical condition, and for screening. Their advantages include confidentiality, convenience,
relatively immediate results and an increased understanding of a condition. Considered by some to be the
“ultimate house call”,1 home diagnostic devices are meant to augment appropriate medical care. Home
testing involves individuals in their health. Advances in technology have increased ease of use and accuracy.
Home testing does not replace appropriate medical care and professional counselling, and there are
potential pitfalls. The privacy afforded by home testing can contribute to misinformation, avoidance of
treatment and even misdiagnosis, all of which may adversely affect health. Some home diagnostic devices
may be inaccurate or inconsistent or test for conditions that may not be appropriate for home testing, e.g.,
metabolic hormone tests.
This chapter addresses home tests for blood pressure, cholesterol, menopause, drug detection, alcohol use,
blood coagulation, celiac disease and urine, and some miscellaneous tests. Two commonly used home
testing measures (blood glucose devices and pregnancy/fertility tests) are discussed in Diabetes Care
Devices and Pregnancy and Fertility Testing.
Blood Pressure
Ailments—Home Testing Products: Electronic Blood Pressure Monitors.
Hypertension is asymptomatic, but is a leading risk factor for morbidity and mortality.2 It is estimated that 1
in 5 Canadian adults have hypertension. One-third of those with hypertension have uncontrolled blood
pressure and one-fifth are unaware that they have hypertension. Of those patients who are aware of their
hypertension only 64% are adequately treated (BP<140/90) with medication.3
Home blood pressure monitoring enables an individual to evaluate whether a new drug or treatment is
working, to chart their course (which may act as motivation for adherence), and to identify “white coat”
hypertension. The Canadian Hypertension Education Program (CHEP) Guidelines suggest that the use of
home blood pressure monitoring on a regular basis should be considered in people with diabetes, suspected
nonadherence, demonstrated white-coat effect, and blood pressure controlled in the office but not at home
(masked hypertension).4
Home blood pressure monitoring should never be considered for self-diagnosis of hypertension. If the blood
pressure is elevated with home blood pressure readings, medical advice should be sought for a definitive
diagnosis of hypertension.5
Electronic Blood Pressure Monitors
Electronic blood pressure monitors are oscillometric, i.e., they measure blood pressure by analyzing
small changes in cuff pressure.6,7 The pressure in the inflated cuff changes as blood moves through
expanding and contracting blood vessels. Most electronic monitors have a liquid crystal diode display
which makes reading the blood pressure numbers easy. Pulse readings are often provided along with
blood pressure readings. Accuracy can be a problem with electronic models. If the reading is
consistently too high or too low, it may still be used to evaluate trends, but if the monitor reads too high
one time and too low the next, readings have no value. Once purchased, electronic models should be
compared in accuracy with blood pressure readings done by a healthcare practitioner. This comparison
should be repeated periodically. Both the British Hypertension Society and the Association for the
Advancement of Medical Instrumentation have formulated validation standards that indicate whether a
particular model is accurate.8 The Canadian Hypertension Society endorses electronic models that meet
the validation standards of these organizations. A heart with a check mark logo appears on the
endorsed models.9
The proper technique for using blood pressure monitors is important, and should be checked from time
to time to ensure no bad habits have developed.5,10,11 The blood pressure reading should be taken under
the same circumstances and at approximately the same time of day. Blood pressure changes with daily
cycles, and is typically the lowest during sleep. Activities that can raise blood pressure include public
speaking (10 mm Hg), strenuous exercise (60–70 mm Hg), sexual activity (up to 100 mm Hg in men and
80 mm Hg in women) and competitive video gaming (20 mm Hg).12,13
Principles of accurate blood pressure measurement include:
Patient should not exercise within the preceeding 30 minutes

Ensure the right cuff size is chosen. Cuff size is based on the measurement of the upper arm. For
people with thin arms less than 23 cm, there are small cuffs. An adult cuff ranges from 23–33 cm; a
large from 33–43 cm. There are also cuff sizes for children
Cigarettes, caffeine and decongestant medications should be avoided for about an hour before the
blood pressure measurement is taken
Sitting in a chair in a warm, calm environment with both feet on the floor, ankles not crossed, is
recommended. The arm in which the blood pressure is to be measured should rest on a firm
surface such as a table, palm up, and at the level of the heart. Bulky clothing can interfere with the
reading and should be removed. Cuff is placed mid-arm, at heart level, with the bottom of the cuff 3
cm from the fold of the elbow
The bladder and bowels should be emptied prior to the reading
Talking while measuring blood pressure will affect the reading
It is recommended that 2 or 3 readings be taken at one time, resting for about 5 minutes between
each reading. The readings can be compared and averaged. Keeping a log of blood pressure
readings will reflect what is normal for an individual and the effect of various activities or
medications on blood pressure readings.
Electronic models that work on the wrist or finger have been developed; however, their use should be
discouraged as they are not as accurate as devices that work on the upper arm.4 Table 1 provides blood
pressure targets for selected patients being treated for hypertension.
14
Table 1: Blood Pressure Targets in Treated Patients
Setting Target SBP/DBP (mm Hg)
Homea <135/85
Office
General patient population (including those with <140/90

chronic kidney disease)
Isolated systolic hypertension Age ≤80 y: SBP<140
Age >80 y: SBP <150
Diabetes <130/80
a Measured by a validated home blood pressure monitor.

Abbreviations: DBP = diastolic blood pressure; SBP = systolic blood pressure
Cholesterol
Ailments—Home Testing Products: Cholesterol Test Kits.
Elevated cholesterol levels increase the risk of coronary heart disease and stroke. It is estimated that 40% of
Canadians have high cholesterol. In-office screening of high-risk individuals and lowering cholesterol levels
with diet or medication reduce mortality and morbidity.15,16
Cholesterol home tests screen only for elevated total cholesterol; it should be noted that the 2012 Canadian
Cardiovascular Society guidelines for diagnosis and treatment of dyslipidemia do not include cholesterol
home tests as a method of screening.15 These tests use an optical reader to determine total cholesterol in a
blood sample. A drop of blood is drawn using a lancet and placed on a test strip. Most test strips do not
require wiping, but rather use capillary action to move the blood sample to the optical reader.
The test strip is impregnated with a reagent that reacts with cholesterol in the blood sample to produce a
colour change. The optical reader uses light absorption to determine the degree of colour change, and thus
the cholesterol content of the sample. The results are expressed digitally on a liquid crystal diode display.
Test results take 3–15 minutes, depending upon the device, and represent total cholesterol. Home tests do
not distinguish among low-density lipoproteins (LDL), high-density lipoproteins (HDL) and triglycerides. To
obtain a breakdown of the cholesterol fractions a laboratory procedure is required.
A record of results may be useful for observing trends in an individual's cholesterol over time and under
various conditions. This may provide an impetus for healthy lifestyle choices.
Menopause
Ailments—Home Testing Products: Menopause Test Kits.
Home diagnostic tests for menopause look for a constantly high level of follicle-stimulating hormone (FSH).
During a normal menstrual cycle FSH levels vary, rising as an ovum matures in the ovaries and falling after
the release of the ovum at midcycle. With decreasing ovarian function closer to menopause, the body
produces less estrogen, causing FSH levels to remain constantly high. However, the Canadian Consensus
Conference on Menopause, 2006 indicates that the measurement of FSH alone is not indicative of
menopause.17
The test is an immunochromatographic one-step test that uses enzyme-linked-immunosorbent serologic

assay (ELISA) to detect FSH in urine. A positive result is indicated by a colour change, and 2 positive tests
taken a week apart indicate a constantly high level of FSH consistent with menopause. Therefore, if the first
test is positive, it should be repeated 1 week later.
A control is built into the test to ensure the test itself is working; however, damaged or expired test material
should not be used. The test should be performed using the first urine of the morning because it has the
highest concentration of FSH. This also ensures the 2 tests are performed at about the same time each day,
minimizing the effect of diurnal variation.
Oral contraceptives and hormone supplements can cause false-negative results by decreasing levels of
FSH. During pregnancy FSH levels are elevated, and an undetected pregnancy will result in a false-positive
result, as will ovarian or pituitary tumors, which increase FSH levels. Many incorrect results are due to
human error—damaging the absorbent end of the test wand, using too small or too large a urine sample,
turning the wand upside down after sampling, reading the results too early or too late.
Home tests alone are not diagnostic of menopause, and other criteria such as cessation of menstrual
periods need to be considered.18 Menopause home tests do not indicate the presence or absence of
fertility, and should never be the basis of a contraceptive decision. Menopause occurs over months and
years, thus menopause home test kits are limited in that they capture FSH levels only in a general
quantitative way at a specific time.
Multiple Drug Detection

Some drugs are abused, are potentially addictive, can impair cognitive functioning and/or are the subject of
workplace drug screening. These drugs can result in health complications and self-harm. Of special concern
are marijuana, phencyclidine (PCP), methamphetamine, cocaine and opiates such as heroin.19,20,21
Home drug detection kits are urine tests that use ELISA technology. Drugs can be detected for 3–30 days
after use, depending upon the drug and its usage. Other drug detection kits use hair or saliva samples which
usually require mailing to a testing laboratory, sometimes located in the United States.
Marijuana can be detected up to 2–8 days after last use; however, with chronic use it can be detected
up to 20–30 days after last use. False-positive results have been associated with hemp-containing
foods (usually labelled as such), NSAIDs (ibuprofen and naproxen) and the proton pump inhibitor
omeprazole. It is not clear whether other members of these drug classes have the same effect.
Second-hand marijuana smoke does not usually cause false-positive results.22
Phencyclidine can be detected up to 3–7 days after the last dose, and 14–30 days after the last dose
with chronic use. Dextroamphetamine, diphenhydramine and ketamine can cause false-positive
results.22
Methamphetamine can be detected 3–4 days after the last dose, and numerous drugs are associated
with false-positive results: amantadine, amphetamine, bupropion, chlorpromazine, desipramine,
dextroamphetamine, ephedrine, labetalol, methylamphetamine or ecstasy, pseudoephedrine,
phenylephrine, selegiline and trazodone.22
Cocaine can be detected up to 8 days after the last dose. Topical anesthetics and coca leaf teas can
cause false-positives.22
Opiates can be detected up to 4 days after the last dose, depending upon the compound ingested.
Dextromethorphan, poppy seeds, quinine, quinolone antibiotics and rifampin can cause false-positive
results.23,24
Adding products like bleach, alum, oxidizing agents and goldenseal will result in a negative test; however, the
test will detect that the urine has been tampered with.25,26
Alcohol
Alcohol use and intoxication can cause loss of alertness, impairment of judgment, coma and death. It is
implicated in automobile accidents and birth defects. After consumption, alcohol is excreted through the
liver and kidneys with 1–5% excreted by evaporation through the breath.
Urine and blood laboratory tests are able to determine alcohol levels; however, home tests measure alcohol
found in the breath. The breath is exhaled onto a test substrate housed in a tube. A colour change indicates
the presence of alcohol, but often not the quantity of alcohol. Some home tests are intended to be carried
on a key chain to be used prior to using a car key.
Breathalyzer tests used by law enforcement agencies also measure alcohol in the breath. These tests utilize
an infrared spectroscopic analysis which extrapolates the amount of alcohol detected to a blood alcohol
level. Alcohol vapour captured in a chamber will absorb a certain wave frequency when light is beamed
through it. The more alcohol present, the more light is absorbed (and thus prevented from reaching a
receptor). A computer chip translates the receptor information into a blood alcohol level. Breathalyzers used
by law enforcement agencies are accurate and can be expensive. Various less-expensive home versions are
available using the same technology,27 but accuracy may vary from product to product.
Blood Coagulation
Ailments—Home Testing Products: Blood Coagulation Monitors.
Home blood coagulation monitors measure prothrombin time (PT) and calculate the International
Normalized Ratio (INR).28 Individuals use home blood coagulation tests in conjunction with a coagulation
clinic and/or laboratory testing in order to adjust their own anticoagulant dosage. The variability of INR
results has been reported to be 15%;29 however, this is similar to the variability in laboratory-obtained
results.
These monitors use a whole blood sample applied to a cartridge, where it is drawn by capillary action into a
channel coated with dried thromboplastin. When the thromboplastin has been rehydrated by the blood
sample, coagulation begins. The mixture will continue to move along the channel until a blood clot forms. A
laser photometer detects cessation of flow as a change in light scattering, resulting in a PT measurement
that is then used to calculate the INR. Results take about 2 minutes. With INR readings above the
therapeutic range, home monitors appear to be less accurate. Home monitoring is not recommended in
patients with antiphospholipid syndrome, but may be less invasive and better accepted than laboratory
procedures in children requiring anticoagulation.
Individuals using home blood coagulation monitors require training, the ongoing support of a coagulation
centre and education on using dosage adjustment guidelines. Record keeping is paramount as is continuing
evaluation of correct technique and accuracy of the monitor. If individuals are considering home coagulation
monitoring, it is important that they work with either their family physician and/or coagulation clinic as well
as their pharmacist. The cost of the monitor and testing supplies may limit their use. Some private
insurance plans may cover associated costs.29
Celiac Disease
Ailments—Home Testing Products: Celiac Disease Test Kits.
Celiac disease occurs largely in Caucasians of Northern European ancestry and is an autoimmune disease.
Estimated prevalence is 1 in 100 North Americans. With exposure to gliadin and related gluten proteins
found in grains such as wheat, barley and rye, the intestinal enzyme transglutaminase modifies the gluten
proteins which in turn trigger the body's immune response. The result is damage to the epithelia and villi of
the small intestine, causing the associated symptoms, such as diarrhea, flatulence, weight loss and
weakness.
Although present even in childhood, celiac disease may not manifest until the fourth decade of life or even
later. There is a familial tendency and with a diagnosis of celiac disease, it is usually recommended that
family members are also tested. Biopsy of the small intestine, genetic testing for a specific HLA-DQ2 gene
(which the vast majority of affected people have) and serological testing for specific IgA antibodies to
transglutaminase are used to diagnose the disease.
A home self-test using ELISA technology is available for detection of the antibody to transglutaminase. The
test uses a blood sample and includes a control; however, data on the accuracy of these tests are limited,
and they cannot be used to confirm or exclude a diagnosis of celiac disease. Patients with symptoms of
celiac disease should consult an appropriate healthcare practitioner for a definitive diagnosis and to
address potential complications including other related immune diseases. A gluten-free diet is the
recommended treatment for celiac disease (see Special Diets).30
Dip-and-read Urine Tests

Ailments—Home Testing Products: Urine Glucose and Ketone Test Kits.
Dip-and-read urine tests are used for a variety of conditions such as pregnancy and fertility (see Pregnancy
and Fertility Testing); however, these home diagnostic tests are also used to test for pH, proteins, glucose,
ketones and other substances.31
Dip-and-read urine tests for protein usually detect albumin, but may not detect other proteins. False-positive
results may be caused by excessive exercise, cold exposure, pregnancy, fever, urinary tract infections,
diabetes, and even changes in posture. If a dip-and-read urine test is positive for protein, medical attention
should be sought since there are numerous potential causes including kidney disease, heart disease, certain
types of cancer, rheumatoid arthritis and lupus.32
Glucose dip-and-read urine tests were used to monitor control of diabetes; however, these have been
replaced by blood glucose monitors. Ketones are the result of the breakdown of fat and are detected in
poorly controlled diabetes and in some diets, e.g., the Atkins diet.33
Urine is usually acidic, with a pH ranging from 4.5–5. Ingestion of proteins or acidic foods can increase the
acidity of urine, and dip-and-read pH tests are used to confirm high-dietary protein intake in patients on high-
protein diets. Kidney disease, urinary tract infections and vomiting are associated with elevated urinary pH;
diabetic ketoacidosis, diarrhea and starvation lead to lower urinary pH.
Dip-and-read urine tests are considered semiquantitative in that the test colour is compared with a colour
chart which represents a range of values.
With dip-and-read urine tests, technique is important:
Collect urine in a clean sample bottle

Wash hands before collecting the sample and clean the genital area
Collect a midstream sample—begin urinating into the toilet, pause, then urinate into the sample bottle
until a sufficient sample is obtained, and if needed finish urinating into the toilet
Completely immerse the test area of the dip-and-read urine test in the collected sample
Shake off any excess urine and read the test according to the directions
If the urine sample is not being used immediately, it should be stored in the refrigerator and allowed to
warm to room temperature prior to testing.34
Fecal Occult Blood Testing

Diagnostic tests for fecal occult blood are not available without a requisition from a qualified healthcare
practitioner. They are often ordered for people at risk of colorectal cancer: over age 50, personal history of
inflammatory bowel disease, polyps or colorectal cancer, or family history of colorectal cancer. Colorectal
cancer is the third most common cause of cancer in Canada with a mortality rate as high as 60%. Early
detection is vital to improved survival, and proper use of these tests is essential.
Since patients may perform these tests at home, the following information may be helpful:35,36,37
A blood loss of 0.5–0.75 mL causes the stool to appear dark red or black and tarry; these tests detect
even smaller or occult amounts
Fecal occult blood testing can differentiate between blood and other substances causing stool
discolouration, such as dietary intake of beets
Increased dietary fibre is recommended, to encourage any lesions to bleed and improve accuracy of
the test
Some foods may interfere with the test and are to be avoided for 48–72 hours prior to testing:
artichokes, broccoli, cantaloupe, grapefruit, horseradish, melons, mushrooms, parsnips, radishes, red or
rare meat, turnips, vitamin C enriched foods
Some drugs can cause inaccurate results: colchicine, corticosteroids, iron, NSAIDs including ASA,
reserpine, warfarin; medical recommendations are usually required regarding these drugs prior to
testing
Some physical conditions can affect test results: anal fissures, bleeding gums, diarrhea, diverticulitis,
hemorrhoids, menstruation, nosebleed, peptic ulcer disease, proctitis and ulcerative colitis. Testing
may need to be postponed until these conditions are managed
Stool samples are retrieved from the toilet bowl, thus the toilet bowl must be free of chemicals such as
toilet bowl cleaners, disinfectants and deodorizers
Since cancerous lesions may bleed intermittently, 3 consecutive stool samples are usually
recommended to minimize the chance of a false-negative.
Examples of Other Home Diagnostic Tests

Although numerous home diagnostic devices are advertised extensively and available via the Internet (see
Table 2), many more sensitive and specific tests are available through healthcare practitioners at little or no
cost (e.g., a laboratory “cholesterol test” measures a complete lipid panel at no expense to the patient).
Before purchase of a home diagnostic test, the following should be considered:
The diagnosis or measurement should be relevant to overall health, e.g., the pH of urine may have no
affect on health
The measurement should provide useful information, e.g., elevated FSH levels are not diagnostic of
menopause; elevated PSA levels are not diagnostic of prostate cancer
The testing kit should be appropriate for home use, e.g., home cholesterol tests may be misinterpreted
Bogus, contaminated, and counterfeit home diagnostic devices do exist and should be avoided.
Healthcare practitioners, the Consumers Union and Health Canada provide information about home
testing and recalls of kits
Some home diagnostic tests are performed entirely at home; others are collection kits with collected
samples mailed to a testing laboratory, sometimes located in the United States. Attention should be
paid to the location of the testing laboratory, because collected samples may degrade in transit.
Confidentiality should be assured for any collected samples sent to a testing laboratory
A good understanding of how to interpret or act on the results of a home diagnostic test is essential
for safe use
Home diagnostic tests that could be potentially dangerous should be avoided, e.g., allergy testing, in
which a potential allergen is used
Simpler, more straightforward alternatives may be available, e.g., using plastic wrap for skin cancer test
kits rather than the transparent sheet that is provided in the kit (see Table 2)
Home testing for infections should always be performed in conjunction with appropriate medical
attention.38
With time, technological changes may make some of these home tests more viable.
An evolving area of home testing is the use of apps for computers and mobile phones. Mental health
assessments, diabetes monitoring, exercise activity, weight loss and food intake are some examples. As
with all home tests, these home testing apps do not replace care provided by healthcare practitioners.
Table 2: Additional Home Diagnostic Tests

Home Diagnostic Mechanism Commentsa
Test
Allergy testing39 Uses a challenge with a substance Allergy testing needs to be

that could potentially cause an performed with medical supervision
allergy. in the event that an allergic reaction
results.
Alzheimer's Uses a scent challenge with various Other causes of changes in smell
disease40,41 odours; in some cases changes in sensation can cause false-positives,
smell sensation is indicative of e.g., nasal congestion; a subjective
Alzheimer's disease. test; an alternative is the Mini
Mental Test.
Test
Helicobacter A test for the gram-negative Fails to identify whether the

pylori42 bacterium responsible for peptic infection is current since antibodies
ulcer disease; an may persist for 6 or more months;
immunochromatographic assay for false-negatives occur when
antibodies to the bacteria using a antibody levels are low.
blood sample and ELISA technology.
Hepatitis43 A test for antibodies to the virus; Uses a blood sample; must be
different assays are able to identify mailed to a testing laboratory,
different viruses, e.g., A, B, C. usually located in the United States.
Human A test for the antibodies to the virus Uses a blood sample; false-
immunodeficiency using ELISA technology; with early negatives result with testing too
virus44,45,46 detection, precautions can be taken early or too late—antibodies take 2–
to prevent transmission of the 8 wk to develop and in late disease
infection. antibody production is low; false-
positives occur in multiparous
women, those with autoimmune
diseases, recently vaccinated
people and those with a history of
multiple blood transfusions.
A 2009 Health Canada Advisory
warned against using these tests—
see
www.healthycanadians.gc.ca/recall-
alert-rappel-avis/hc-
sc/2009/13392a-eng.php.
Influenza47 A nasal swab used in a 3-step Appropriate medical consultation is

procedure to detect antigens to preferred.
influenza A and B.
Male fertility48,49 A test for quality and quantity of Uses a reagent to stain the sperm in
sperm. the sample; resulting colour is
compared with a quantitative colour
chart.
A test for DHEA and/or testosterone. Uses a saliva sample.
Metabolic A test for 1 or more metabolic Uses a saliva sample.

hormones, e.g., hormones depending upon the
cortisol, thyroid50 testing capacity of the kit purchased.
Prostate A test for prostate specific antigen Uses a blood sample for in-home
cancer51,52 (PSA) which is elevated in prostate detection; benign prostate
cancer. hyperplasia, prostatitis, autoimmune
disease or sexual activity within 48
h of testing may produce false-
positives; some rapidly growing
tumors do not elevate PSA levels.
Test
Skin cancer53 A test for changes in appearance of Uses a transparent sheet that is
skin growths. placed on the skin and any growths
are traced; changes over time are
noted.
Streptococcal A throat swab is tested using ELISA Both are difficult to use with
infections54 technology for bacterial antigens. uncooperative children.
Throat and ear examination kits with
fully illustrated guide books.
Tobacco use55 A test for nicotine or cotinine, a Uses a saliva or urine sample for in-
nicotine metabolite; cotinine can be home testing; testing of a hair
detected up to 4 days after tobacco sample provides results of up to 90
has been used. days after tobacco has been used;
however, the hair sample must be
mailed to a testing laboratory,
usually located in the United States.
Urinary tract A urine dip test for nitrites produced False-negative results may be
infections56 by gram-negative bacteria from caused by vegetarian diets,
nitrates, or for leukocyte esterase, tetracycline, high intake of vitamin
indicating the presence of C.
leukocytes in the urine.
Vaginal A test strip worn as a “panty liner” Normal pH of vaginal secretions is

infections57 which detects the pH of vaginal 4–4.5; bacterial and trichomonas
secretions by a colour change. infections raise the pH to 5–6:
inaccurate results occur with
sweating, during menstruation, less
than 1 day before or 5 days after a
menstrual period, within 48 h of
intercourse or douching, with
menopause and within 72 h of
applying a vaginal product such as a
contraceptive cream.
a
Availability of these tests may vary: most are not available for direct purchase in Canada and must be obtained
and/or analyzed via laboratories in the United States.
Potential Home Diagnostic Testing Problems

Many home tests focus on health conditions that are represented by national health organizations, e.g., the
Canadian Diabetes Association. These organizations may have information and/or guidelines regarding the
test, including the accuracy and appropriateness of use. Human error is the primary reason for failure or
erroneous results when home testing.
Care in preparing, administering and interpreting the results is needed:
Note the accuracy of the test as well as the substance for which the test is designed (e.g., cholesterol
tests measure only total cholesterol and do not provide a lipid profile)
Read all directions and identify all test components prior to testing
Check the kit expiry date; do not use an expired test kit
A clean, undisturbed, well-lit area is ideal for testing; test surfaces should not be touched, and hands
should be washed prior to testing to reduce potential contamination
If the test equipment or monitor uses batteries, make sure they are charged
Directions for sample collection, including the best time of day for collection, should be followed
carefully and any timing should be done accurately with a timer, watch or clock with a minute hand
If the test uses a control and it fails, results are invalid and should not be used
Interpretation of the results is essential; e.g., the meaning of a positive or negative result, and when to
seek medical attention
The calibration of monitors should be checked on a routine basis
If testing is ongoing (e.g., blood pressure), keep a log or diary
If the subject resists the test procedure (e.g., taking a blood or urine sample or throat swab) the sample
may not be adequate and the result inaccurate
The required manual dexterity and eyesight is also essential
Human error can occur at each step of a test; tests with fewer steps have less potential for human
error
Many manufacturers have toll-free telephone numbers and websites that are useful resources
Home diagnostic tests offered via the Internet may not be recognized as accurate, may not be
approved for use in Canada, or may require sending a sample to a central laboratory in a manner that
degrades the sample.
References
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3. Statistics Canada. Blood pressure of Canadian adults, 2009 to 2011. Available from:
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4. Canadian Hypertension Education Program (CHEP). Hypertension Canada. 2015 CHEP
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6. van Egmond J, Lenders JW, Weernick E et al. Accuracy and reproducibility of 30 devices for self-
measurement of arterial blood pressure. Am J Hypertens 1993;6:873-9.
7. Rotch AL, Dean JO, Kendrach MG et al. Blood pressure monitoring with home monitors versus
mercury sphygmomanometer. Ann Pharmacother 2001;35:817-22.
8. Bultemeier NC, White JR, Campbell RK. Home monitoring of blood pressure. US Pharm 2001;26:81-
90.
9. Hypertension Canada. Devices endorsed by Hypertension Canada. Available from:
hypertension.ca/en/devices-endorsed-by-hypertension-canada. Accessed October 29, 2015.
10. King DS et al. Educating patients on hypertension and blood pressure monitoring. Drug Topics
1998;142:1.
11. Hypertension Canada. Measuring blood pressure the right way [poster]. Available from:
www.hypertension.ca/images/2013_EducationalResources/2013_MeasureBPPoster_EN_HCP1040.pdf.
12. National High Blood Pressure Education Program Working Group report on ambulatory blood
pressure monitoring. Arch Intern Med 1990;150:2270-80.
13. Pickering TG, James GD, Boddie C et al. How common is white coat hypertension? JAMA
1988;259:225-8.
14. Canadian Hypertension Education Program (CHEP). Hypertension Canada. 2015 CHEP online
guidelines. Available from: guidelines.hypertension.ca. Accessed October 29, 2015.
15. Genest J, McPherson R, Frohlich J et al. 2009 Canadian Cardiovascular Society/Canadian guidelines
for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the
Information for the Traveller
Mark Kearney, BSc(Pharm), MSc

Introduction
Today's travellers seem to be exposed to more risks than they ever have in the past. A number of factors,
ranging from an aging population to global warming, have contributed to this situation. Ease of travel has
contributed to the development of areas of the world that were once considered exotic and remote. While
the presence of resorts at these destinations supports the comfort of the traveller, they can give the traveller
a false sense of security with regard to the health risks that may be present. Canada has an aging
population with the financial means and the desire to travel. However, they are more likely to be on treatment
for chronic medical conditions and are less likely to receive optimal benefit from vaccinations, two factors
that leave them at increased risk for travel-related illnesses.
Generally speaking, any traveller to a tropical destination or developing country should receive a pre-travel
assessment from a healthcare practitioner certified in travel health. The assessment will identify current
risks for the traveller based on their destination and the type of activities they are planning, and it will inform
them of the required and recommended vaccines that can help them reduce their risks to diseases.
Information provided in this chapter focuses on nonprescription medications and healthcare advice to
assist the patient in reducing their health risks. Patients may also need help to determine their pre-travel
needs for vaccinations and other related prescription products. To assess their needs, key information will
be required, including their destination, the type of activities they intend to do, an up-to-date vaccination
history and a list of their current medications.
Online references can support travellers in making informed decisions about their travel health needs,
including the need to seek a pre-travel assessment from a qualified healthcare practitioner. Those who
frequently assist travellers seeking pre-travel information will find it beneficial to make themselves familiar
with online references provided within this chapter.
Travel First Aid Kits

First aid kits designed for various types of travel can be purchased from camping equipment stores. Basic
first aid kits can be purchased from the Canadian Red Cross or from Saint John Ambulance. Alternatively,
first aid kits can be prepared by purchasing the necessary supplies from a pharmacy. The contents of these
kits will vary depending on the destination and remoteness and type of travel. A partial list of medications
and supplies that could be included in a first aid kit can be found in Table 1. Items for the first aid kit should
be organized in a sealed plastic bag or a plastic box.
Medications
Analgesics: Acetaminophen is effective for the relief of mild to moderate pain and the reduction of fever
(see Fever). Ibuprofen or naproxen will effectively relieve pain and fever and help in controlling
inflammation.
Antacids: An antacid (e.g., calcium carbonate, aluminum and magnesium hydroxide) is effective in the
relief of indigestion and heartburn (see Dyspepsia and GERD).
Antidiarrheals: Both loperamide and bismuth subsalicylate are effective in the management of mild
travellers' diarrhea.1 Bismuth subsalicylate can also be used as a preventive agent.2 More severe
symptoms (e.g., with cramps, bloody diarrhea or fever) require antibiotic therapy (see Diarrhea).
Antihistamines: Antihistamines can be used to treat minor allergic reactions (see Allergic Rhinitis and
Atopic, Contact, and Stasis Dermatitis). Certain antihistamines (e.g., dimenhydrinate) are useful to
control symptoms associated with motion sickness3 (see Nausea and Vomiting).
Antiseptics: Clean water can be used to wash minor cuts or abrasions. If the risk of infection is high
cleanse the area with hydrogen peroxide 3% or isopropyl alcohol 70% to prevent skin infections (see
Minor Cuts and Wounds).
Decongestants: Oral pseudoephedrine is useful in adults for relieving congested eustachian tubes during
descent of an aircraft.4 Topical decongestants are generally not useful for this purpose4 (see
Complications Affecting the Ear: Ear Piercing, Foreign Bodies and Barotrauma).
Emergency contraception: Oral levonorgestrel is available without a prescription at pharmacies and can
be used by female travellers to significantly reduce the risk of pregnancy in instances of contraceptive
method failure (e.g., broken condom), unprotected consensual intercourse or in cases of sexual
assault5,6 (see Contraception).
Insect repellents: Insect repellents containing DEET (N, N-diethyl-m-toluamide) or icaridin are effective
against a variety of mosquitoes, ticks, fleas, chiggers and flies. Preparations containing soybean oil 2%
and p-menthane 3,8 diol (PMD; oil of lemon eucalyptus) are also effective. See Personal Protection
Against Vectors, below.
Laxatives: A laxative on its own or in combination with a stool softener (see Constipation) may be
helpful for constipation arising from factors associated with travel (e.g., dietary changes, dehydration).
Table 1: Travel First Aid Kits

Category Items
Medications Analgesic Decongestant Oral rehydration salts
Emergency
Antacid contraception Sunscreen
Topical antibiotic
Antidiarrheal Corticosteroid cream cream/ointment
Topical antifungal
Antihistamine Insect repellent cream
Topical antipruritic
Antiseptic agent Laxative lotion
First aid supplies Adhesive bandages Ice pack Sterile gauze
Adhesive tape Safety pins Thermometer
Fine tweezers Scissors Moleskin
Paper and pencil Latex or vinyl gloves Triangular bandages
Matches and candle Syringes and needles
Oral rehydration salts: Oral rehydration salts prevent dehydration due to travellers' diarrhea (see
Diarrhea). Alternatively, sports drinks, diluted 1:1 with potable water offer an alternative means of
rehydration.7
Corticosteroid creams: Hydrocortisone 0.5% or 1% cream is useful in various skin conditions such as
mild dermatitis and pruritus. Hydrocortisone lotion is more effective in treating larger areas. Clobetasone
0.05% is slightly more potent than hydrocortisone and also available without a prescription for the
treatment of similar conditions8 (see Atopic, Contact, and Stasis Dermatitis).
Sunscreens: Sunscreen with a SPF of 30 or greater and UVA blockers (e.g., mexoryl, parsol) helps
prevent sunburn (see Prevention and Treatment of Sun-induced Skin Damage).
Topical antibiotic creams or ointments: Topical antibiotic (e.g., polymyxin B/gramicidin/bacitracin) can
be used on superficial wounds likely to become infected (see Minor Cuts and Wounds).
Topical antifungal creams: Antifungal cream (e.g., clotrimazole, miconazole) can be used to treat topical
Candida infections associated with heat and humidity9 (see Fungal Skin Infections).
Topical antipruritic lotions: Lotions containing local anesthetics and antipruritics provide temporary
relief of itchiness associated with mild allergic reactions10 (see Atopic, Contact, and Stasis Dermatitis
and Insect Bites and Stings).
For comparative features or ingredients of nonprescription products, consult the Compendium of

Products for Minor Ailments.
Jet Lag
Jet lag presents with symptoms of malaise, fatigue, disruption of sleep-wake cycles, irritability and impaired
cognitive performance, which result from rapidly crossing multiple time zones and attempting to follow the
time schedule at the new destination.11 Typically, these symptoms are more severe when travelling
eastward than westward.11 This is because it is easier to adjust by extending the day rather than shortening
it.11,12,13 As a general rule, it takes 1 day to acclimatize for every hour of time difference at the new
destination.
Nonpharmacologic methods of minimizing jet lag symptoms include:11,12
If travelling for 2 days or less, follow the time schedule at the point of departure vs. the time schedule
at the destination
In cases of extended travel, adjust sleep and awakening times by 1 hour each day for several days prior
to departure in an attempt to coincide with the time change at the final destination13
Exposure to bright light in the early morning (5:00 a.m. to 11:00 a.m.) will advance the internal clock,
and exposure in the evening (10:00 p.m. to 4:00 a.m.) will delay it. Eastward travellers should seek light
in the morning and westward travellers should seek light in the evening13,14
Plan to arrive at new destination in the early evening (destination time) when possible
Anticipate the new time zone. Sleep on the plane if the arrival is in the morning and stay awake if arrival
time is in the evening
Be well rested prior to travel
Stay well hydrated during the flight by drinking plenty of fluid; avoid in-flight alcohol and caffeine
Exercise during the flight by stretching and walking; this is particularly helpful when the traveller wants
to remain awake
Exposure to outdoor daylight at the destination may help in resetting the circadian rhythm
Remain active during daylight hours on arrival at the destination and adopt local mealtimes
Plan on sleeping the same amount in a 24-hour period as when at home.
Endogenous melatonin is produced in the pineal gland.11,15,16 It is normally secreted at nighttime, between
the hours of 9:00 p.m. and 8:00 a.m. Melatonin acts on the internal clock governing circadian rhythms, such
as sleeping and body temperature. When these rhythms are disrupted, as with jet lag, sleep disturbances
can occur. Several studies show that exogenous melatonin is effective in alleviating the symptoms of jet lag
at doses of 3–5 mg daily.15 Timing of the administration appears to be important. Melatonin taken in
advance of departure may actually worsen the symptoms of jet lag compared to melatonin taken nightly
starting after arrival at the destination.16 It may be more effective to take a lower dose (0.5 mg) of
melatonin later in the night when crossing multiple time zones on westward trips so as to avoid overlap with
endogenous secretion.14 Dosage form also appears to be important. Sustained-release preparations seem
to be less effective than immediate-release formulations.15 In studies melatonin was effective when taken
for 3–5 days after arrival,15,16 but can be continued until symptoms of jet lag (e.g., daytime fatigue)
subside.17 Travellers should be aware that short-term use of melatonin can cause abdominal cramps,
dizziness, drowsiness, headache, irritability, nightmares and transient depressive symptoms, but the
incidence of these adverse reactions is low.15
High-altitude Illness
Travellers to destinations at altitudes above 2000 metres are at risk of altitude-induced illness.18 This term
encompasses acute mountain sickness (AMS), high-altitude cerebral edema (HACE) and high-altitude
pulmonary edema (HAPE).19 Symptoms of AMS typically occur within the first 48 hours after reaching a new
altitude, especially with rapid ascent. The symptom of HACE and HAPE results from the extravascular
movement of fluid in the brain and lungs. HACE is the end-stage of AMS and can be fatal. The progression
to HACE from mild AMS ranges from 12 hours to 3 days. HAPE can occur without pre-existing AMS and
accounts for most deaths from high-altitude illness.19 Symptoms for each type of altitude illness are listed
in Table 2.
While there are individual variations in susceptibility, the risk of illness increases directly with the rate of
ascent, the altitude at which one sleeps and the altitude reached.21 At altitudes between 2000 and 3500
metres, 9–34% will experience symptoms of AMS. Above 4000 metres, 42% will experience these
symptoms.18
Gradual, step-wise ascent is the best method of prevention. Travellers should heed the following:
Ascend slowly and avoid direct transport to altitudes above 3000 metres
Spend 1 or 2 nights at 2500–3000 metres before going higher
Above 3000 metres, sleeping altitude should not be increased by more than 300–400 metres per night
with a rest day (a second night at the same altitude) for every 1000 metres of altitude gained21
Plan day trips to higher elevation with a return to a lower sleeping altitude to accelerate
acclimatization.21
20
Table 2: Clinical Presentation of Variants of High-altitude Illness (Lake Louise Consensus)
Acute Mountain High-altitude Cerebral
Sickness Edema High-altitude Pulmonary Edema
In the setting of a recent In the setting of a recent In the setting of a recent gain in
gain in altitude, the gain in altitude, either: altitude, the presence of the following:
presence of headache the presence of a Symptoms—at least 2 of:
and at least one of the change in mental
following symptoms: dyspnea at rest
status and/or ataxia in
gastrointestinal a person with AMS, or cough
(anorexia, nausea the presence of both weakness or decreased exercise
or vomiting) mental status changes performance
fatigue or and ataxia in a person chest tightness or congestion
weakness without AMS Signs—at least 2 of:
dizziness or
crackles or wheezing in at least 1
lightheadedness
lung field
difficulty sleeping
central cyanosis
tachypnea
tachycardia
Abbreviations: AMS = acute mountain sickness
Travellers should avoid alcohol, sedative-hypnotics and heavy exertion at high altitude.21 In addition,
prophylaxis with acetazolamide 125 mg po twice daily is indicated for rapid ascents (24 hours or less) to
>3000 metres and rapid increases in sleeping altitude (e.g., 1000-metre increase in altitude within 24 hours).
Acetazolamide 250 mg po twice daily can also treat AMS if started early enough after symptoms appear.18
Dexamethasone 4 mg po twice daily for up to 10 days may be used to prevent symptoms, but does not
improve acclimatization and should be used in combination with temporary descent so as to facilitate
acclimatization.18,21
Treatment of AMS includes rest and acclimatization at the same altitude. This may take between 12 hours
and 4 days. Simple analgesics, e.g., ibuprofen 200 mg po every 6 hours, may help treat headache. Descent
of at least 500 metres is indicated if AMS is severe, if symptoms progress during acclimatization or if
symptoms of HACE or HAPE occur.21 For more information, see Suggested Readings.
Heat and Cold-induced Illnesses
Heat Illnesses
Trips to warmer climates put travellers at risk for heat-induced illness, typically classified as heat
exhaustion or heat stroke. Heat exhaustion occurs when the core body temperature rises to between
37°C and 40°C. Heat stroke occurs at core temperatures greater than 40°C, although elevated
temperature is not required for diagnosis. It may take up to 10 days for the thermoregulatory system to
fully adapt to increased demands placed on it by high temperatures and humidity.22 See Heat-Related
Disorders for a discussion of the signs and symptoms of various heat-related illnesses and their
management.
Travellers can take steps to prevent heat-related illnesses including the following:
Avoid long periods of strenuous physical activity during the first few weeks after arrival at a warm
destination
Maintain adequate hydration and electrolyte intake (see Fluid Requirements)
Avoid alcohol.
Be especially cautious if taking medications that increase the risk of heat-related illnesses, such as
amphetamines, anticholinergics, antiepileptics (e.g., topiramate), antipsychotics, beta-blockers, calcium
channel blockers, diuretics, MAOIs and sympathomimetics.23
Cold Illnesses
Cold illnesses involve either changes in core body temperature (hypothermia) or localized cold-induced
tissue injury (e.g., frostbite).
Hypothermia is defined as a core body temperature of less than 35°C. It can be further classified as mild
(core body temperature >32°C and <35°C), moderate (core temperature 28–32°C) or severe (core
temperature <28°C).
Frostbite is defined as tissue necrosis resulting from localized hypothermia of peripheral tissues.24 More
details can be found in Frostbite.
Certain medical conditions (e.g., hypothyroidism, diabetes, peripheral neuropathy, autonomic neuropathy,
peripheral vascular disease) and use of medications/substances (e.g., alcohol, antipsychotics, clonidine,
meperidine, nicotine/tobacco, sedatives) predispose travellers to cold illnesses. Environmental factors
such as wind and moisture can increase the risk of cold illnesses.25
In general, medical treatment should be sought immediately for cold-related illnesses as inappropriate
rewarming can cause complications. For mild hypothermia, external rewarming (e.g., blankets) is usually
sufficient if the affected person is able to generate heat through shivering. Moderate to severe
hypothermia is considered a medical emergency.25 For more information, see Suggested Readings.
Personal Protection Against Vectors

A vector is an organism that plays a role in the transmission of a pathogen between humans or from animal
to human.26 Vectors include fleas, tsetse flies, sand flies, ticks and certain freshwater snails. Mosquitoes
are also important vectors. The Anopheles mosquito is responsible for transmission of malaria, and the
Aedes mosquito transmits the dengue and chikungunya viruses. In addition, the Aedes mosquito transmits
Zika virus, which is a developing concern for travellers. Consult recommended references (see Table 4) for
appropriate precautions when travelling to areas where Zika may be present.
A traveller's risk of exposure to a vector depends on the destination, the type and location of
accommodations, the duration of the visit and the type of travel planned.
Risk reduction measures include sleeping in well-screened or air-conditioned areas, sleeping under
mosquito nets (preferably insecticide-treated), wearing clothing that provides good coverage (e.g., long
sleeves, trousers, socks) and using insect repellents. In regions where schistosomiasis (transmitted by
freshwater snails) is endemic, contact with freshwater (e.g., lakes, slow running streams) should be
avoided.27 When hiking in tick endemic areas, closed-toed footwear should be worn and pants should be
tucked into socks. Additionally, hikers should check for burrowing ticks on the skin after each trek.28,29
Screens and mosquito nets should have a mesh size of 1.5 mm or less and should be checked regularly for
holes. Mosquito nets impregnated with insecticides (e.g., permethrin) are significantly more effective in
preventing malaria than nets without insecticide. Impregnated nets also deter entry by vectors smaller than
the mesh size of the net (e.g., sandflies) and are safe for use by children and pregnant women. Permethrin-
treated nets remain effective even after laundering. All mosquito nets should either reach the floor all
around the bed or be tucked under the mattress. In areas with high pyrethroid resistance, there may be some
benefit to combining treated nets with non-pyrethroid insecticide sprays.30
Insect Repellents
Repellents containing diethyltoluamide (DEET) offer prolonged protection against mosquitoes and other
biting insects. Icaridin offers similar levels of protection.31 Repellents containing 2% soybean oil are
also effective for shorter durations of exposure (90–200 minutes).32,33
The duration of effect of insect repellents varies according to a number of factors, including the
concentration of repellent and amount applied, temperature and, possibly, wind conditions.28 It is
decreased by sweating, washing and abrasion. Health Canada recommends using a repellent containing
DEET or icaridin (picaridin).31 Various concentrations of DEET and icaridin are available and these vary in
their duration of effect.31 Using a formulation containing more than 30% DEET is not recommended,
since the duration of effect is not lengthened above this concentration but the risk of toxicity may be
increased.31 In children aged 6 months to 1 year, a product containing DEET 10% or less should be
applied daily. DEET 10% can be applied 3 times a day in children aged 2–12 years.31 In Canada, DEET
and icaridin products are not recommended for use in children under 6 months of age. In areas where
malaria and other insect-borne diseases are endemic, the risk of severe disease outweighs any risk from
properly applied products.31 DEET has been shown to cross the placenta. However, although there are
few formal studies, there is no evidence that the use of DEET by pregnant or breastfeeding women poses
a health hazard to unborn babies or children who are breastfeeding.34 See Insect Bites and Stings for
more information on available insect repellents.
28,31
Correct Application of Insect Repellents
Test for allergy before using a repellent for the first time by applying to a small patch of skin.
Reactions are rare and have typically been reported to occur within 15–30 minutes of
application with concentrations of DEET higher than those available on the Canadian
market.35,36
Apply sparingly to exposed skin, including the face, wrists, ankles and neck. To apply to the face,
dispense repellent into the hands, rub the hands together, then apply to face, taking care to
avoid the mouth, eyes and nose.
Health Canada recommends that sunscreen be applied at least 20 minutes prior to the
application of DEET-containing insect repellent if both are to be applied to the same area.37
Wash hands after application to avoid inadvertent transfer of repellent to eyes, mouth and nose.
Do not apply to broken or inflamed skin.
Do not apply to children's hands or face.
DEET may be applied to clothing made from cotton or wool. It may damage acetate, rayon,
spandex, nylon and other synthetic materials. Do not apply DEET under clothes.
Malaria
Up to 30 000 travellers from industrialized countries contract malaria each year38 and fatalities have been
reported in North America in returning travellers. The Centers for Disease Control provides an excellent
online resource to help travellers determine whether their itinerary includes areas where malaria is endemic
(wwwnc.cdc.gov/travel/). Advise travellers to make an appointment at a travel clinic to discuss options for
chemoprophylaxis, and to take precautions to prevent insect bites (see Personal Protection Against
Vectors).
Uncomplicated malaria typically presents with “flu-like” symptoms (fever, chills, sweats, myalgia, and
headache) that may recur at intervals of 48–72 hours. Gastrointestinal symptoms (nausea, vomiting) may
also be present, but are more common in children versus adults. However, this cyclical pattern is rarely seen
in the most severe form of malaria, caused by P. falciparum. Symptoms of severe P. falciparum malaria
usually occur about 10–12 days after infection and include jaundice, impaired consciousness, prostration,
abnormal bleeding and convulsions. Without prompt treatment, respiratory and renal failure, shock, coma
and death can occur within 3–7 days. Symptoms caused by other malaria species may appear from 14 days
to many months after infection and are typically not life-threatening. Travellers should be advised to seek
immediate medical attention if a persistent or cyclical fever develops within a year after returning from a
malaria risk area.39
Dengue Virus
Dengue Virus
Dengue virus has become a significant international health concern. The World Health Organization (WHO)
estimates that 50–100 million infections, 500 000 dengue hemorrhagic fever cases and 22 000 deaths
occur globally each year. Children are more likely to require hospitalization and are more likely to die from
the disease than adults.40 Dengue is the leading cause of systemic febrile illness and the second-most
common cause of hospitalization among travellers returning from the Caribbean, South America, South
Central Asia and Southeast Asia.41 Local transmission of dengue virus has been reported in Southern
Europe and the Mediterranean and the presence of dengue virus has been confirmed in 36 countries
previously thought to be dengue-negative, including the state of Florida.41,42 Dengue viruses are transmitted
to humans through the bites of infective female Aedes mosquitoes or via exposure to dengue-infected
blood.
Dengue fever (DF) is a severe, flu-like illness but seldom causes death. The incubation period is typically 4–7
days (range 3–14 days). Many travellers infected with dengue virus are asymptomatic. DF is defined
clinically by an acute febrile illness with 2 or more of the following symptoms:41
Headache
Retro-orbital pain
Muscle or joint pain
Rash
Hemorrhagic manifestation or leukopenia
The rash usually appears as the fever subsides, and lasts 2–4 days. The rash is either macular or
maculopapular and generalized, often confluent with small patches of normal skin, and it may become scaly
and itchy.
Approximately 1% of patients with DF develop dengue hemorrhagic fever (DHF) as the initial fever subsides
(usually 3–7 days following onset). Sequential exposure to different strains of the dengue virus is believed
to increase the risk of DHF.43 Without treatment, the fatality rate of DHF is approximately 5%.44 For more
information, see Suggested Readings.
There is currently no vaccine or medication to protect against dengue. As the Aedes mosquito is most active
during the daytime, precautions against insect bites should be taken during daylight hours whenever
travelling to areas of risk for dengue fever (see Personal Protection Against Vectors).
Chikungunya Virus
Chikungunya is a viral disease spread through the bite of an infected Aedes mosquito. Symptoms of the
disease typically begin within 3–12 days of exposure and can mimic dengue fever.
Symptoms include:
Fever
Headache
Arthritis-like joint pain or swelling
Rash
Chikungunya infection is usually not fatal, but joint pain may persist for months to years or cause chronic
disability.
Until recently, chikungunya outbreaks have been confined to Africa, the Americas, Asia, the Pacific Islands
and the Indian subcontinent. However, local transmission of the virus was reported for the first time in
Southern Europe in 2007 and on the Caribbean island of Saint Martin in December 2013. Since 2013, local
transmission of the virus has been reported on many other islands in the Caribbean, and in Central and
South America, Mexico and Florida.45 In the first half of 2015, over 10 000 cases of chikungunya were
confirmed in South and Central America and the Caribbean.46 In 2014, the Public Health Agency of Canada
reported an increase in travel-related chikungunya cases reported in Canada.47 For more information, see
Suggested Readings.
There is no vaccine or medication to protect against chikungunya and no treatment. Precautions against
insect bites should be taken during daylight hours whenever travelling to areas of risk for chikungunya (see
Personal Protection Against Vectors).
Travelling with Medication

When travelling, all regularly used medications, as well as any emergency or intermittent-use items (e.g.,
asthma inhalers, nitroglycerin sprays, epinephrine injectors), should be packed in carry-on luggage.
Travellers are advised to take extra amounts of each medication as well as a list of all medications (use the
generic or chemical name) in case of emergency. Most pharmacies can prepare a list of current prescription
medications, provided those medications were filled at the same pharmacy.
Medication should be stored in the original, labelled container to avoid problems at borders and to facilitate
drug identification in case of emergency. Consider placing silica packs in medication vials if extended travel
is planned in hot, humid environments.
Travellers who must bring syringes and needles to administer injectable medications (e.g., insulin, low
molecular weight heparin) should carry a letter from their physician authorizing such possession, which
should be presented at customs. When an itinerary includes significant changes in altitude (above 2000
metres), pressure in vials for injection must be equalized. To do this, insert the needle of an empty syringe
(without the plunger) into the upright vial for several seconds. Then proceed with the usual withdrawal and
injection procedures.48
Insulin is stable at room temperature for 30 days. Insulin that will not be used within that time period or any
medication that requires refrigeration must be kept cool for the duration of travel. This can be accomplished
using a cooler or a chilled thermos. The medication should then be refrigerated once the destination is
reached.
All nonprescription liquid medications, creams or ointments must be purchased in volumes of 100 mL or
less to be allowed through airport security in carry-on luggage, and must be placed in a clear, 1 L resealable
plastic bag. This volume limit does not apply to prescription medications.
If tablets or capsules might experience rough handling (e.g., backpacking), blister packing may prevent
breakage. Alternatively, placing cotton wool in the prescription vial may be helpful.
Before travelling, people who use controlled drugs or nonprescription codeine preparations should check
with embassies or consulates of the destination country and any country through which the person will
travel en route. Regulations vary, and what is legal in Canada may not be permitted in another country.
Travellers requiring oxygen therapy during air travel should contact the airline in advance.12
Most airlines will accommodate travellers with special diets if informed at least 24 hours in advance.
Venous Thromboembolism Prophylaxis

Long-distance travel is associated with a risk of venous thromboembolism (VTE) estimated at 0.1–4.8
cases per million travellers.49 The incidence of VTE is highest in the first 2 weeks after travel, gradually
decreasing to normal 8 weeks afterwards.50 The magnitude of this risk depends on a variety of factors:
Type of travel: factors such as a hypobaric environment and decreased oxygen tension may put air
travellers at greater risk of VTE than other forms of travel51,52
Duration of travel: flights over 4 hours are associated with a two-fold increased risk of VTE while flights
greater than 8 hours show the strongest association with VTE occurrence50,53,54
Frequency of travel: frequent flying (multiple flights greater than 4 hours within an 8-week period)
increases the risk for VTE50
Pre-existing individual risk factors: previous VTE, cancer, pregnancy, advanced age, recent surgery, leg
fractures and factor V Leiden or other genetic clotting disorders all increase risk for VTE50,53,54
Medication use: use of oral contraceptive or estrogen-based hormone replacement therapy has been
shown to increase the risk of VTE as could other medications that promote clotting (e.g., tranexamic
acid)49,50,53
Immobility during travel can increase the risk of VTE51,54
Extremes of height and weight: travellers shorter than 162 cm or taller than 185 cm and travellers with
a BMI >30 kg/m2 are at increased risk of VTE.50,53
Seventy to 90% of travellers experiencing VTE have one or more of the pre-existing individual risk factors
listed above.49 Travellers at high risk of VTE (e.g., cancer, recent surgery, hypercoaguable disorder, obesity)
should be assessed by a qualified healthcare practitioner. Recommendations to prevent VTE among high-
risk travellers on long flights include:
Maintain adequate hydration (avoiding alcohol will help)54

Contract the muscles in the calves regularly or get up out of the seat often. Sit in an aisle seat if
feasible54
Wear below-knee graduated compression stockings, providing 15–30 mm Hg of pressure at the
ankle.54
ASA does not appear to reduce the risk of travel-related VTE and is not recommended as prophylaxis in
high-risk travellers.55
Travel Clinics
It is recommended that when travelling outside Canada or the United States, travellers should plan a pre-trip
visit to their healthcare practitioner or a travel clinic at least 4–6 weeks before their trip. This is important, as
there are specific vaccination requirements that vary depending on the planned destination. Travel clinics
also provide other services such as assessment of malaria risk and need for expanded medical kits as well
as advice on personal protection against vectors.
Travel clinics are available across Canada. For a full listing, visit the Public Health Agency of Canada web
site at www.phac-aspc.gc.ca/ and click on the “Travel Health” link.
Travel Health Information Resources

Travellers seeking English-speaking physicians can inquire with hotel receptions, tour companies or
Canadian embassies. The International Association for Medical Assistance to Travellers (IAMAT) will supply
a directory of English-speaking physicians in 125 countries and territories (Table 3).56 IAMAT physicians
have agreed to provide services with set fee schedules.56 Membership in IAMAT is free of charge although a
small donation is requested to help support its work.
Table 3: Summary of International Association for Medical Assistance to Travellers (IAMAT) Services
Membership card—entitles bearer to services and fixed IAMAT rates
World directory—a directory of English-speaking physicians in 125 countries and territories
who have agreed to a set payment schedule
Traveller clinical record—a passport-size record completed by one's doctor prior to departure
World immunization chart—provides information on preventive measures
World malaria risk chart and protection guide—a guide to malaria prophylaxis
World schistosomiasis risk chart and information brochure—provides information on
preventive measures against schistosomiasis
World climate chart—summary of climate in any part of the world
IAMAT CANADA: 2162 Gordon Street, Guelph, Ontario N1L 1G6

Tel.: 519-836-0102
Fax: 519-836-3412
www.iamat.org
67 Mowat Ave., Suite 036, Toronto, Ontario M6K 3E3

Tel.: 416-652-0137
A variety of commercial databases and Internet sources are available for travel information. Even among
reputable websites, conflicting information can be found, and careful consideration by the user is needed.
Selected useful websites for travel information are listed in Table 4.
In addition, travellers may contact Global Affairs Canada for information on safety and security
considerations (1-800-267-6788 or www.international.gc.ca).
Table 4: Web Sites for Travel Medicine Recommendations for the Health Care Practitioner
Web Site URL Description
Centers for Disease wwwnc.cdc.gov/travel/ US recommendations; Yellow Book:

Control and Prevention Health information for international
(CDC) travel
Committee to Advise on www.phac-aspc.gc.ca/tmp- International travel health

Tropical Medicine and pmv/catmat-ccmtmv/index- information for health professionals
Travel (CATMAT) eng.php
Public Health Agency of www.phac-aspc.gc.ca Regularly updated including

Canada information on outbreaks and a list
of clinics providing travel health
services in Canada
World Health www.who.int General travel advice; country-

Organization (WHO) specific malaria risk and antimalarial
recommendations
Water Concerns for Travellers

Safe drinking water is essential for travellers to foreign countries, as well as for backpackers within Canada,
who rely on water from streams, ponds, rivers and lakes.
Fluid Requirements
To function optimally, males require an average intake of 3 L of water a day and women require an
average of 2.2 L.57 Fluid is replenished by consuming water, other beverages and solid foods. Because it
is difficult to measure the total amount of fluid obtained by eating food, it is recommended that only
fluids be counted toward meeting the daily requirement. Physical exertion increases fluid loss and more
fluids should be consumed. Processed bottled water or other bottled beverages are preferable sources
of fluids, but not always accessible while travelling. If bottled beverages are used, the seals on the
bottles should be checked to ensure they have not been refilled with unprocessed liquids. Otherwise, the
methods listed below should be used to treat water prior to consumption.
Unsafe Water
Drinking unsafe water may result in acute infections within hours or days, marked by vomiting, diarrhea,
fever, malaise and/or abdominal pain. Diseases contracted by drinking contaminated water may be of
viral, bacterial or protozoal origin and include amebiasis (E. histolytica), cholera, cryptosporidiosis, E. coli
enteritis, giardiasis (G. lamblia), hepatitis A, Shigella enteritis and typhoid fever.58,59 A survey of travellers
showed that young people were more likely to experience gastrointestinal illness.60 Except for E. coli,
cholera, typhoid and hepatitis A, vaccines are not available to protect travellers against most of these
diseases. Simple precautions to minimize the risk of infection are described in Diarrhea.
Water treatment methods outlined in this chapter are directed at preventing infectious illnesses from
bacteria, viruses and protozoa. However, environmental contaminants (e.g., copper, mercury, lead,
pesticides, herbicides) may also exist in water that has not been processed for human consumption. It is
best to verify with a local guide whether the drinking water source is suitable for humans.
While physical appearance is not a reliable indicator of safety, turbidity may not only indicate
contamination, but may also interfere with disinfection.59 Cloudy water should be strained through a
filter.29,58,59,61 It can then be boiled or chemically treated with iodine. Once purified, water should be
stored in clean, covered containers to reduce the chance of recontamination. Water treated with chlorine
or iodine remains drinkable for several days without refrigeration. Water treated by other means should
be consumed within 2 days.59
Recommended Water Treatment Methods
Heat
Boiling water is the most reliable, and therefore the preferred, method of purifying water for
drinking.59 Boiling eliminates bacteria, viruses and protozoa. Water should be boiled vigorously for 1
minute then allowed to cool to room temperature.59 At altitudes greater than 2000 metres above sea
level, water should be boiled for 3 minutes, or boiled for 1 minute then chemically treated with
iodine.29 Boiled water may taste flat; adding a pinch of salt or oxygenating the water by pouring the
water back and forth between two clean containers can improve the taste.29
29,59
Table 5: Iodine Products for Water Purification
Iodination Procedure
Tincture of iodine 2% solutiona Add 5 drops (0.25 mL) per L of clear water, or 10 drops
(0.5 mL) per L of cold (<5°C) or cloudy water. Mix
thoroughly and let stand for at least 30 min before
drinking. Very cold or cloudy water should be allowed to
stand several hours before use, if possible.
Saturated iodine solutionb Add 12.5 mL per L of water and let stand for 15–20 min;
add 20 mL per L and let stand for at least 20 min if cold
or cloudy water.
Tetraglycine hydroperiodideb Add 1 tablet per L of room temperature water and wait
15 min before use. Use 2 tablets per L of cold or turbid
water and wait 20 min.
a
Available in first aid kits and from pharmacies.
b
Available at camping equipment stores and drug wholesalers.
Iodination
Iodination is recommended only for short-term use (<2 weeks) if boiling is not feasible.29,58,59,61
Contact time of the iodine in water should be extended if the water is very cold or cloudy. Ideally, to
remove protozoal cysts such as G. lamblia and Cryptosporidium, water should be first poured through
a filter with an absolute pore size of one micrometre or less, then iodinated to kill viruses and
bacteria.29,58,59,61 Iodination should be used with caution in children and avoided in pregnant women
and travellers with thyroid disease.29,58,59,61 Prolonged ingestion of iodine may lead to
hypothyroidism or hyperthyroidism, goitre, hypersensitivity, iodism or poisoning, which is manifested
by corrosion of the GI tract, metallic taste, vomiting and abdominal pain.62 Iodine also crosses the
placenta and is excreted into breast milk.62 Iodine may stain and imparts an unpleasant taste to the
water; palatability can be improved by adding a vitamin C tablet or powdered drink crystals prior to
consumption. Table 5 lists iodine products appropriate for water purification and describes their use.
Chlorine
Treatment of water with chlorine bleach is not as reliably effective as iodine. Chlorine treatment
alone may not kill some enteric viruses, G. lamblia and E. histolytica cysts and Cryptosporidium
species.29 If chlorine is used, add 2 drops (0.1 mL) household chlorine bleach to 1 L water (4 drops if
water is cloudy), mix and let stand 30 minutes (longer if water is very cold).59 Another product,
chlorine dioxide, does kill Giardia effectively and has moderate effectiveness against
Cryptosporidia.63 Chlorine dioxide does not have an unpleasant taste, but is appropriate for only
short-term use.
Filters
Water treatment devices such as filters, micro filters or portable iodine-impregnated resin devices are
available from camping equipment stores. Filters or micro filters are available with small pore sizes
(0.1–0.3 micrometre). They may remove protozoa, G. lamblia cysts and large bacteria, but will not
remove viruses.29 Filtration alone is therefore inadequate to purify water. Although filtration is not
mandatory, it complements heating or iodine treatment, if it is used first to remove large particles.
Filters with iodine-impregnated resins are more effective against bacteria than protozoa and viruses.
The contact time with the iodine in the filter is too short to kill Giardia in cold water, Cryptosporidium
and some viruses.3
Suggested Readings
Centers for Disease Control and Prevention. 2016 Yellow book. Atlanta: U.S. Department of Health and
Human Services, Public Health Service; 2016. Available from: wwwnc.cdc.gov/travel/page/yellowbook-
home.htm.
Government of Canada. Travel health kit. Available from: travel.gc.ca/travelling/health-safety/kit.
World Health Organization. Poumerol G, Wilder-Smith A, eds. International travel and health 2012. Geneva:
WHO Press; January 1, 2012 and 2014 and 2015 updates. Available from: www.who.int/ith/en/.
References
1. DuPont HL, Ericsson CD, Farthing MJ et al. Expert review of the evidence base for self-therapy of
travelers' diarrhea. J Travel Med 2009;16:161-71.
Medical Devices and Aids to Daily Living
Marie Berry, BSc(Pharm), BA, LLB

Date of Revision: November 2015
Introduction
Medical devices and aids to daily living (also called assistive devices) are an integral part of the
contemporary home healthcare market. It is a growing segment of health care. In 2012, estimates placed
the size of the Canadian medical device market at approximately $6.8 billion.1 The market itself is broad
and, in addition to traditional items such as medical equipment, includes first aid and wound care products,
sports medicine items, incontinence aids, palliative care products and diagnostic equipment.
Several factors have combined to create this expanded market—longer life expectancies, technological
advances and economies involved in modern health care.
The Canadian population is living longer because of advances in medical knowledge and technology. Over
time, more elderly people will be living in their homes, requiring medical and assistive devices to carry on
their day-to-day living.
Improved technology enables individuals to stay at home or to go home earlier from hospital, and also
permits earlier diagnosis and self-care management.
In general, treatment in hospitals is expensive, and both medical and assistive devices allow less costly
home-based treatment. Patients are discharged earlier from hospital with home recovery, and not-for-
admission or “day” surgery is more common.
The use of medical and assistive devices has economic advantages and provides an improved quality of life
by reducing or even eliminating a person's disability. Orthopedic patients (e.g., those with hip replacements
or fractures) can be more mobile and independent during postoperative recovery periods. Individuals with
brain damage (e.g., from trauma or stroke) or cerebrovascular disease (e.g., vascular dementia) can be
better equipped to support daily living and self-care management. Patients with rheumatoid arthritis,
amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS) are better equipped to manage their diseases.
Patients with amputations can return home to await rehabilitation programs. Caregivers use medical and
assistive devices to facilitate the care they provide.
Medical Devices
Medical devices include a wide range of items. The legal definition is any article, instrument, apparatus or
contrivance, including any component, part or accessory thereof, manufactured, sold or represented for use
in the diagnosis, treatment, mitigation or prevention of a disease, disorder or abnormal physical state or its
symptoms.2 The definition also includes devices that could be used to restore, correct or modify a body
function or body structure, to diagnose pregnancy, and to care for pregnant individuals and their offspring. It
is a broad definition and at one time included products intended for animal use; however, the Medical
Devices Regulations address products for human use only.3
In general terms, a medical device is any item of equipment, product or system that is ready-made,
customized or adapted and used to maintain or improve functional capabilities of people with a permanent
disability or a temporary impairment or physical limitation. When choosing a medical or assistive device,
several factors need to be considered. The physical, cognitive and emotional characteristics of the person
for whom the piece of equipment is intended affect the choice. For example, a self-propelled wheelchair
may increase mobility; however, if the individual does not have the physical strength or endurance to propel
it, an electrical model may be a better choice. The nature of the activity needs to be considered, e.g.,
whether the medical or assistive device is to be used at work, at home or in a social setting. Considerations
include the social and cultural context, and whether the device is to be used in an institution or by the
individual or caregiver. The degree of complication of the technology involved in the equipment is also a
factor.
While a broad range of medical devices are listed in Table 1, this appendix focuses specifically on home
safety equipment, mobility aids, patient comfort aids, respiratory aids and home intravenous equipment.
Diagnostic tests intended for home use, wound care products, incontinence aids and ostomy products are
discussed elsewhere (see Diabetes Care Devices, Ostomy Care, Dressings, Pregnancy and Fertility Testing,
Urinary Incontinence and Home Testing).
Table 1: Medical Devices

Category Examples
Home safety equipment Bathroom safety: Mobility and transfer:

bath rails and poles walkers and canes
bed pans and urinals wheelchairs
commodes
shower chairs
transfer benches
Home diagnostic tools Blood glucose monitors Ovulation testing kits

Blood pressure monitors Pregnancy testing kits
Cholesterol testing kits
Patient comfort aids Adjustable beds Elastic compression stockings

Back, neck and limb braces Pressure therapy
Cushions Pillows
Respiratory aids Asthma nebulizers Spacers for inhalers

Nasal irrigation devices Vaporizers, humidifiers
Peak flow meters
Wound care products First aid products Surgical bandages

Specialized dressings
Incontinence aids Bedwetting alarm systems Under pads

Drainage bags Undergarments
Protectors and sheaths Urinary catheters
Surgical sundries Ear plugs Medicine measuring devices

Gloves Personal hygiene products
Manicure accessories
Sports and orthopedic Belts Massagers

products Braces Supports
Hot/cold therapy
Home intravenous Accessories such as tubing,

products infusion pumps, needles,
syringes
Sensory aids Hearing aids Magnifying glasses

Home Safety Equipment
Home safety equipment is durable medical equipment that is able to withstand day-to-day wear and is
intended for in-home use. At one time, high quality equipment was available only in hospital or
institutional settings, but today such equipment is intended for in-home use, either by the individual
alone or with the assistance of a caregiver. Home safety equipment can be divided into 2 groups that
represent the majority of these types of devices: equipment for bathroom safety and equipment for
mobility.
An area of growth is equipment designed for use by bariatric patients. In 2013, about 36% of Canadian
adults were considered overweight and 26% obese.4 Bariatric equipment is generally indicated for
individuals with a body mass index (BMI) of greater than 30. The majority of standard equipment such as
wheelchairs, walkers or bath chairs is intended for individuals weighing up to 250 pounds. Bariatric
equipment is wider, made from heavy-duty material and is intended for people weighing more than
standard equipment can support. The weight-carrying capacity is usually listed on the equipment.
Equipment for Bathroom Safety
Half of all falls involving Canadian seniors occur at home, with stairs and bathrooms posing the
greatest risk.5 Getting into or out of the bathtub presents a risk and bath oil and bubble bath increase
risk by making tubs more slippery.
Showers are an alternative, but some individuals have difficulty standing in a shower. Chairs designed
to be used in the shower are an option. Something as simple as a bath mat with suction cups
reduces the risk of falls. Bathtub and shower grab bars and poles, along with tub rails, make a
bathroom safer.6 Hand-held or portable shower nozzles facilitate washing while standing or sitting.
Shampoo Trays and Caps
For people confined to bed or in a wheelchair, shampoo trays make washing hair possible. Rinse-
free shampoo caps are now being used in and out of hospital to allow cleaning of the hair without
the use of running water.
Inflatable Bathtubs
Inflatable vinyl tubs fit over a bed and come with a hand-held shower and hose, making bathing in
bed a possibility.
Bath Boards/Bathtub Transfer Benches
Bathtub transfers are the greatest cause of anxiety in individuals with permanent or temporary
physical limitations, as this is when most falls occur. Requiring assistance in a bathtub transfer
may be a sign of lost independence and privacy to some individuals.
Bath boards sit across the tub and usually have handgrips. They are ideal for storing soap and
sponges within easy reach and for helping to maintain stability when stepping out of the bathtub.
Bath boards are anchored to the inside tub edges with adjustable clamps/grips. The board is the
same height as the tub edge and allows the individual to sit on the edge and slide across the
board for a sit-down shower or sponge bath.
Transfer benches straddle the bathtub with 2 legs outside the tub and 2 legs inside the tub. The
individual sits on the seat outside the bathtub, much like they would in a chair. While seated they
can move their legs 1 at a time over the bathtub edge and into the bathtub, pulling themselves
over to the portion of the seat positioned above the bath water. See Figure 1.
Transfer benches have adjustable heights but are not suitable for deep designer bathtubs. Several
trial runs while fully clothed and without bath water are recommended, to adjust the bench to the
correct height. The sitting surfaces must be slippery enough so that the transfer is easy, but not
so slippery that someone may slide off the surface, especially when it is wet. Transfer benches
and boards usually have water drainage holes in the seat surface to prevent the seat from
becoming too slippery.
Transfer benches should be easy to clean and if not permanent, they should be light and easy to
position. Suction cups and/or rubber tips limit movement of the equipment during transfers. Most
have side grab bars and backrests. They should be adjustable so that a person can enter the tub
from either the right or the left.
Figure 1: Use of Bathtub Transfer Bench
Bath/Shower Seats
Bath/shower seats have 4 legs set inside the tub or shower, allowing an individual to sit down
while bathing. Some have backrests, and all have suction cups or rubber tips on the legs to
prevent them from slipping. Suction-cup legs, adjustable leg heights, back support, and nonslip,
easy-to-clean surfaces are desirable features.
Raised Toilet Seats
Raised toilet seats facilitate sitting down and getting up from the toilet and enable more
comfortable transfers from wheelchair to toilet seat. Most raised toilet seats add 4 inches to the
toilet height, although some are adjustable up to 6.5 inches. For safety reasons, raised toilet seats
should attach directly to the toilet bowl by means of clamps. Raised toilet seats are portable and
can be used when travelling.
Some raised toilet seats have a cut-out area for leg positioning in patients with limited range of
movement at the hip or other conditions that prevent a normal flexed sitting position (e.g.,
following hip-replacement surgery).
Raised toilet seats may have attached hand grips. A safety bar can be attached to the wall next to
the toilet and hand rails can be used on a regular-height toilet. A trial run will help with the
appropriate placement. See Figure 2.
Figure 2: Raised Toilet Seat With Cut-out For Leg Positioning
Miscellaneous
Assistive devices such as wash mitts, wash sponges (some have a pocket for a bar of soap),
long-handled scrubbing brushes/sponges and tap turners make bathing easier and may help
prevent falls. The toilet tissue dispenser should be within easy reach. Various toilet assistive
devices enable individuals with limited manual dexterity to use toilet tissue and clean themselves.
Splashguards can be attached to any commode seat that sits higher than the toilet bowl.
Equipment for Mobility
Decreased mobility for an individual may mean limited participation in activities of daily living and/or
being housebound, bedridden or even institutionalized. Also, decreased mobility has associated health
risks such as thromboembolism. Equipment for mobility includes canes, walkers and wheelchairs.
Canes and Walkers
Canes and walkers increase safety and confidence with mobility by reducing instability. Aluminum
canes and walkers are lightweight and adjustable, thus easily manoeuvred and ideal for individuals
who, because of age or disease, do not have optimal muscle strength. Wooden canes are often
heavier and must be cut to adjust the length.
Canes and walkers should be measured to ensure a correct fit.7 The distance from the top of a cane
or walker handle to the ground should equal the distance from the wrist crease to the ground, when
the arm is straight down at the side. The measurement should be performed with the individual
standing erect and wearing everyday shoes. If the cane is too short, the user will lean forward. If it is
too long they will lean backward. Adjustable and telescopic canes enable an individual to find the
correct fit. Walkers are measured in a similar manner, and most are adjustable.
A cane handle should afford an easy yet firm grip. A swan's neck handle is easier for balancing, and
many handles have moulded grips. Metal and wooden cane tips or walker feet tend to slip. Rubber
tips are required to help prevent slips and falls, and are replaceable. A flip-back ice-gripping tip can be
attached to the tip of a cane for extra stability in winter. Quad bases (4 legs) add balance to canes
and different sized bases are available for stability. Although canes are most comfortably held in the
dominant hand, holding the cane in the hand contralateral to the weak or injured side will provide the
most balance.
Walkers may have wheels on 2 or 4 legs, and the wheels may be permanent or removable. Some
walkers feature a handbreak which will lock the rear wheels. Walker accessories include tote bags,
baskets, trays and attached seats. A folding walker eases transportation.
Crutches
Crutches are used as mobility aids and support for knee, leg, or ankle injuries. They may be required
on a short- or long-term basis, depending upon whether the injury heals or is ongoing. There are 2
broad categories: forearm or elbow crutches, which are used more often on a long-term basis, and
axillary or underarm crutches, which are mainly for short-term use. See Figure 3.
Forearm crutches have handgrips and the crutches extend above the wrist where they are secured by
a cuff or collar at the forearm. The majority of forearm crutches are adjustable; however, the
appropriate fit is needed. With the arms relaxed at the sides of the body, the handgrip should be level
with the wrist. The cuffs should fit around the forearm just below the elbow with a space of 1–2
inches to allow the elbow to bend. The flex in the elbow ideally should be 15–30 degrees for stability
and comfort.
Figure 3: Styles of Crutches

Axillary (underarm) crutches provide support for a lower body injury. The arm pads should not be
tight against the axilla, but rather there should be space enough for 2 or 3 fingers or about 1–1.5
inches between the arm pad and the axilla. The handgrip should be adjusted so that with hands in
place the arm is flexed about 15–30 degrees. Most crutches are adjustable to ensure proper fit.
If one crutch is used it should be used opposite the injury; however, with 2 crutches it is important to
remember to move the crutches first, then the body. Forearm crutches are more difficult to learn to
use, but they enable the user to be mobile on various surfaces and are ideal for more active
individuals with a chronic injury.
Various handgrips are available. Some have extra padding or gel covers and others have ergonomic
design. Forearm crutches have a variety of cuffs for comfort and durability. Some forearm crutches
have hinged cuffs allowing the crutch to drop away when the wearer reaches for an object. See
Figure 4. The arm pads of axillary crutches are also available with a variety of padding for comfort.
Figure 4: Hinged Forearm Crutch

Tips for using crutches:
Good posture is key for proper fit and use. Slouching over crutches leads to muscle strain and
pain. Leaning too far in front of or behind the crutches results in instability and increased risk of
falls.
Nonskid shoes can help prevent falls when using crutches.
When learning to use crutches, practice is important for preventing falls and increasing mobility.
Balance, coordination, and upper body strength are needed for using crutches. While forearm
crutches provide greater mobility, they also require more balance, coordination, and upper body
strength. Axillary crutches may be a better option for a first-time user.
Crutch tips are usually rubber and slip resistant. They should be inspected regularly for wear
and replaced if worn.
Wooden and metal crutches are both available. Metal crutches, especially aluminum, are lighter
and more durable.
When carrying several items, a backpack is recommended to avoid interference with crutch use.
Routine inspection is needed to ensure screws or fasteners are not loose and crutch tips or
pads are not worn.
Wheelchairs
Wheelchairs should provide comfortable and functional mobility.8 Consider the everyday routine of
the individual before choosing a wheelchair because the choice can vary depending on activities
(e.g., going to work, participating in sports). More than one wheelchair may be required to perform
different activities.
The method of propulsion of the wheelchair may be independent or assisted by another person.
Independent propulsion refers not only to propelling wheels or hand rims manually, but also to the
use of electrical controls with the hand, mouth, legs or feet.
Positioning of an individual in a wheelchair should provide adequate balance and support. The
buttocks should bear equal loads, with adequate back support. Ideally, the shoulder should align
vertically with the elbows, with the arms resting at right angles. The knees and ankles should be at
right angles as well. When the individual's centre of gravity is ahead of the wheelchair axle the
wheelchair is more stable, while propulsion is easier when the centre of gravity is over the axle.
People with severe disabilities may not be able to achieve the ideal position, and adaptation of the
chair may be needed.
Wheelchair seat dimensions should fit with body dimensions. A chair that is too large or too small
does not function well for the user. The seat and back should not sag. To ensure proper positioning,
seat height and individual requirements, the patient should be assessed while sitting in the chair.
The environment in which the chair will be used is a key factor.9 If the chair is to be used indoors, its
size and manoeuvrability must be considered as well as the architectural features of the building or
room in question. Measure doorways and check the turning axis of the chair to ensure the wheelchair
fits through doorways, both at home and at work.
Wheelchairs used outdoors should be able to negotiate uneven ground, slopes and curbs. This is a
major limitation of wheelchairs in that they were designed to function on man-made surfaces, and
perform poorly outdoors (e.g., in the park, on the beach).
Wheelchairs used for leisure activities may require high-performance features and should be easy to
transport. Appearance and styling may be important. Certain sports (e.g., basketball, track) require
specialized wheelchairs that are light and durable with easy manoeuvrability.
When travelling by car, close access to the car seat eases transferring between chair and car.
Lightweight chairs with detachable or swing-away armrests and footrests make transfers and
transportation easier. Transporter wheelchairs are lightweight and foldable, intended for occasional
use such as shopping in a mall or moving through an airport.
Wheelchair accessories can increase comfort and mobility, and can reduce health risks. Wheelchair
cushions reduce pressure sores and support the head. Harnesses and seat belts provide support and
increase safety. Trays, bags, stump boards, umbrellas and rain hoods, pushing gloves and cuffs,
portable ramps, padding, specialized cushions and transfer boards are other examples of wheelchair
accessories.
Wheelchair manufacturers use different terms to describe the same features. Check with the
manufacturer to clarify the terms and descriptions.
Table 2 summarizes considerations involved in selecting a wheelchair.
Table 2: Selecting a Wheelchair

Features Options/Considerations
Frame Amputee Regular, lightweight or bariatric construction

Indoor or outdoor Style
use Tilting, reclining or standing
Seat height/depth Standard Bariatric

Hemiplegic or low Variable
seat
Arm rests Fixed Full length

Removable Desk length
Swing-away Wrap-around
Backrest Height Sectional, adjustable, contoured

Reclining
Features Options/Considerations
Footrests/legrests Fixed Removable

Pivoting or swing- Elevated
away
Propulsion Regular drive Foot propulsion

One-handed drive Electrical
Wheels Spokes Pneumatic, semi-pneumatic or solid tires

Composite Wheel locks
Quick-release axle Anti-tip devices
Caster
width/diameter
Esthetics Upholstery and Individual's self-image, personality and

frame colour preferences
Capabilities of chair Home Community

Work Outdoor vs. indoor
Leisure/sports Terrain
School
Fit Seating and Size, weight, endurance, cognitive and

postural needs perceptual status of user
Range of motion
Cost Availability of In the case of children, changes in size

funding
Life expectancy of
the wheelchair
Patient Comfort Aids
Patient comfort aids include pressure therapy, pillows, cushions, elastic compression stockings and
back, neck and limb braces. Some of these devices are used therapeutically as well as for comfort.
Pharmacies may facilitate the supply of larger equipment such as adjustable beds.
Elastic Compression Stockings
Elastic compression stockings are also known as surgical or support stockings or hose. In the
simplest form, support stockings are intended to relieve tired, aching legs and prevent swelling of
feet, ankles and legs. Individuals who stand or sit for long periods of time or older individuals with
compromised venous return are ideal candidates for these stockings. Compression stockings may
be prescribed for medical conditions such as varicose veins, lymphedema, venous eczema and
ulceration, deep vein thrombosis, and post-thrombotic syndrome.10
Elastic compression stockings decrease superficial venous pressure, increase the upward flow in
unoccluded deep and superficial veins and raise local interstitial pressure. Compression of the leg
also prevents some edema. They are designed to give gradual support with the most pressure
exerted at the ankle, less at the calf and the least at the thigh.11 Stockings provide varying
compression, ranging from 12–60 mm Hg at the ankle. No single standard classification of
compression is used. The most common is: low or class 1 of less than 20 mm Hg; medium or class 2
of 20–30 mm Hg; and high or class 3 of >30 mm Hg.
A correct fit requires accurate measurements of the nonedematous leg, first thing in the morning. To
ensure effective compression, the stocking should be washed and dried according to the
manufacturer's directions and replaced every 2–3 months. They are intended to be removed at night
and put on in the morning before beginning daily activities. Manual dexterity is needed to put on or
remove the stockings, and devices are available to assist with this.
Compression stockings are available as pantyhose or socks (above or below the knee), with open or
closed toes and in various colours. See Figure 5. The required compression and affected leg area
should be the starting point in selection.
Antiembolism stockings are worn by the nonambulatory individual, to prevent venous emboli caused
by inactivity. They provide less support and are not suitable for ambulatory individuals.
Nontherapeutic elastic stocking are widely available and often used by air travellers or by people who
feel they have “tired legs”. Precise measurements are not needed and the compression is usually
uniform.
Proper fit is essential to ensure comfort and effectiveness. Ill-fitting stockings may be the reason an
individual discontinues wearing them. Some stockings, especially ones with high compression, may
be esthetically unappealing for some wearers and they may not be worn. The most common reasons
for not being able to wear compression stockings include: skin damage (especially seeping, open
wounds), allergy to any of the stocking components, extensive leg edema or a malformed leg, a
history of peripheral artery disease, and marked impairment of sensation in the leg.
Figure 5: Compression Stocking Styles
Respiratory Aids
Peak Flow or PEF Meters

Along with established predictive value of respiratory symptoms, peak flow meters help predict and
prevent exacerbations in a chronic pulmonary condition such as asthma. They allow home
monitoring of a patient's lung function and titration of medication but it is important that use of a
peak flow meter be linked to an action plan. Use of peak flow meters is contentious and the Canadian
Thoracic Society notes that most people do not require monitoring of peak expiratory flow (PEF).
Home monitoring may be suitable for adult patients who are poor perceivers of airway obstruction
and by patients with severe asthma; however, in many cases, monitoring of symptoms may be
sufficient.12
Peak flow meters measure the peak expiratory flow (PEF) rate, or the speed of air that can be forced
out after the lungs are fully inflated. PEF meters consist of a mouthpiece with a gauge, an indicator
and a scale. There are usually 2 mouthpieces to accommodate either children or adults.
After a complete exhalation, the individual inhales as deeply as possible, places the meter in the
mouth and blows out as hard and fast as possible. The final position of the indicator on the scale is
the PEF measured in litres per minute. Three consecutive readings are taken, and the highest of the 3
is recorded. Children as young as 4 years are able to perform this test.
While it is recommended that daily measurements be taken at 12-hour intervals, (e.g., 7 a.m. and 7
p.m.), measurements should be taken at times that are convenient and clinically significant for the
individual. Measurements are recorded in a log or graph and many meters come with a graph. A note
is made if inhaled corticosteroids or beta-agonists are used either before or after the test. These
values are compared to “predicted normal” values depending on age, race, gender, height and weight.
A better approach is comparison to the individual's personal best which is the highest PEF recorded
over a 2- to 3-week period during which asthma is under control.
A zoning system is usually used to make the test reading relevant for the patient. One frequently used
zoning system is based on traffic lights. A result in the green zone correlates to 80–100% of the
individual's personal best, yellow 60–80%, and red <60%. In the yellow zone, medication may have to
be re-evaluated, and in the red zone a bronchodilator is immediately required. If a reading appears in
the red zone twice within a 48-hour period, medical attention should be sought.
Problems that can cause false readings include the wrong size of mouth piece, the indicator not
being at the bottom of the scale before the test is begun, fingers blocking part of the mouthpiece
opening and atmospheric pressure effects. To ensure accuracy of peak flow meters, individuals
should be encouraged to take their meter to appointments with healthcare practitioners, to compare
the readings with spirometry results.
Vaporizers/Humidifiers
Vaporizers use heat to disperse moisture in the air, which increases the temperature of the space in
which they are used. Steam or spills from vaporizers can cause burns. Humidifiers require no heat.
They increase humidity by physically dispersing water droplets in the air.
The use of distilled water prevents some mineral buildup in humidifiers; however, vaporizers require
some minerals in the water to produce vapour. Regular cleaning of humidifiers and vaporizers is
essential to remove debris and limit microbial growth, thus reducing the risk of infection and allergic
reactions. Medication should not be added to humidifiers and if used with vaporizers, should only be
placed in the medication cup (not the water reservoir).
Nasal Irrigation Devices
Nasal irrigation devices are used to remove excess mucous from nasal cavities. Also termed nasal
lavage or douching, nasal irrigation can be useful as an adjunct to oral therapy in treating the
symptoms of rhinosinusitis and chronic sinusitis. Various devices are available, for example the neti
pot (see Figure 6), but all use the technique of pouring saline into one nostril and allowing it to drain
through the other nostril. Gravity and tilting the head facilitate the procedure.
Figure 6: Neti Pot

Oxygen Therapy
Ambulatory and hospice patients may require oxygen therapy. With the available technology (e.g.,
face masks, nasal cannulae, oxygen concentrators, tracheal or endotracheal tubes), oxygen therapy is
more portable.
Oxygenated water and ozone therapy are touted as beneficial; however, both are expensive and lack
evidence supporting their effectiveness.
Continuous Positive Airway Pressure Machines
Continuous positive airway pressure (CPAP) machines are used to treat obstructive sleep apnea-
hypopnea syndrome. Individuals affected by the syndrome experience cessation of breathing (apnea)
or shallow breathing (hypopnea) during sleep, which affects the quality and quantity of sleep and
results in daytime drowsiness. A mask fits over the face and the CPAP machine maintains an air
pressure in the mask that is slightly greater than the surrounding air, which promotes normal
breathing. Adherence to CPAP therapy is low; the machine itself is cumbersome, and other potential
factors include sleep disturbance and claustrophobia. Education, correct fit of the mask, and air
humidification of the bedroom may increase use.
One symptom of obstructive sleep apnea-hypopnea syndrome is snoring. Various devices are
available to reduce snoring along with the sleep apnea-hypopnea. Oral appliances reposition the
mouth allowing improved breathing and adhesive nasal strips applied to the bridge of the nose open
nasal passages.
Home Intravenous Programs
Patients with chronic illness and serious infections may require long hospitalizations away from family,
friends and work; however, they might be well enough to reside at home if they were able to obtain the
required medication. Home intravenous programs have been developed to meet this need.13
Examples of therapies that can be administered through home intravenous programs include:
Antibiotic therapy for diseases such as infective endocarditis, septic arthritis, cystic fibrosis and
osteomyelitis
Chemotherapy for conditions such as breast cancer, Hodgkin's disease, leukemia or testicular
cancer
Parenteral nutrition for patients with short bowel syndrome, inflammatory bowel disease, chronic
intractable diarrhea or chronic idiopathic intestinal obstruction syndrome.
The majority of home intravenous programs involve antibiotics.14 Other potential therapies include
parenteral nutrition, chemotherapy, analgesia, clotting factors for hemophilia, fluid therapy, and biologics
(e.g., infliximab, natalizumab, rituximab).
Home intravenous programs represent one of the fastest growing segments of the home health care
market. Several factors are responsible:
More reliable equipment (e.g., better catheters, home infusion pumps)

Increased patient awareness and involvement
Cost savings
Home health support from healthcare practitioners.
To succeed with a home intravenous program, a patient and their family must feel comfortable with the
technology and skill required. The patient must have adequate cognitive function and no psychosis or
drug addiction problems, both of which can adversely impact adherence (see Table 3).
Table 3: Criteria for Candidates of Home Intravenous Programs

Positive Criteria Negative Criteria
Medical stability Substance abuse

Manageable infection/disease Impaired vision
Adherence to program Home without running water, electricity,
Sufficient cognitive function refrigeration
Venous access
Most home intravenous patients have a venous catheter to which tubing and a prepared intravenous
drug are attached. The drug infusion takes place over a specified period of time and is accomplished
either by gravity or with the use of a pump. The catheter chosen may be a short peripheral line, midline or
central line (e.g., Broviac, Hickman or Groshong) depending on duration of therapy, the need for blood
sampling, age of the patient, drug properties (e.g., vesicant) and other factors.14 A heparin lock may be
used.
Subcutaneous infusion pumps are implanted devices used to infuse medication, blood products, fluids
or nutrition. The pump appears as a raised area under the skin surface. There is a port with a self-sealing
silicone rubber septum through which a Huber needle is inserted. The medication enters the body
through tubing attached to the Huber needle.
Analgesic pumps are portable external devices that pump analgesic medications, typically morphine,
through tubing and into a small needle placed in the subcutaneous tissue. The pump controls the flow of
medication and is usually programmed to provide a set dose per time period. The pump can also be
used manually with the patient having some control over dosage, but the pump is programmed to
provide a limited quantity per time period. The pump is hung outside the tub when showering or bathing
and placed under the pillow or hung on a hook when sleeping. Avoid exposing the pump to humidity, heat
or freezing.
Parenteral nutrition bypasses the GI tract completely and is infused into the circulation. With total
parenteral nutrition (TPN) there may be a loss of GI function, thus returning to orally provided nutrition
may be problematic.
Complications
Phlebitis, infiltration and infection at the catheter site are the most common problems. Air emboli,
dislodged catheters, migrating ports, catheter leaks and occlusion can also occur. Prepared
intravenous solutions must be stored carefully, most often in the refrigerator and sometimes in the
freezer.
Aids to Daily Living (Assistive Devices)

The term “aids to daily living” refers to assistive devices that make day-to-day life easier for both individuals
and caregivers by facilitating performance of personal care tasks (e.g., clothing with Velcro closures, handle
grips for cutlery, wheelchairs and canes). Assistive devices can enable an individual to avoid
institutionalization.15
Assistive devices are often recommended by occupational therapists who evaluate and recommend
adaptations that enable an individual's daily living activities to continue. Mastering the correct technique for
using an assistive device can enable individuals to relearn an old skill, perform an old task in a new manner,
or use equipment to perform a task.16 The emphasis is on simplifying tasks, planning ahead, organizing the
task, sitting and resting regularly when possible, and using correct body mechanics. Table 4 lists some
common aids to daily living.
Table 4: Examples of Aids to Daily Living

Dishes Partitioned; lip or raised edge; suction cup fixed on base; heated; food
guards.
Cups Easy-to-hold handles; detachable handles; attached straws and/or spouts;

nose cut outs; weighted bases; insulated; holders to stabilize.
Utensils Plastic coated spoons; weighted handles; easy to hold grips; swivel
utensils; extension handles; specialized handles for odd angles; foam
tubing to increase grip; putty to create a customized grip.
Kitchen Electric and manual knives and peelers with easy-to-hold handles; cutting
boards with nails to hold food for cutting; cutting boards with corner
guards; easy-to-use and hold can and jar openers.
Home accessories Doorknob and tap turners and grippers; easy-grip scissors; long reach
sponge mops, dusters and vacuums; reading lights and magnifiers; book
holders; reachers.
Personal care Extension combs and brushes; handle grippers for toothbrushes; zipper
pulls; elastic shoelaces; sock and pantyhose aids; button hooks; adaptive
clothing.
Communications Games, stickers and communication boards; pen grips; computer

accessories.
Recreation Playing card holders and shufflers; large size edition of games; knitting
needle holders; hand cuffs and mobile bridges for pool cues.
Tips for Using Medical and Assistive Devices

To gain the most benefit from medical and assistive devices, they should be used correctly:
Measurements must be accurate to ensure a correct fit. Read the directions carefully and be sure the
correct units are used (e.g., if the manufacturer lists sizes in inches, do the measurement in inches).
With any medical or assistive device that requires assembly, read the instructions carefully. One option
is to have it pre-assembled.
All directions for use should be thoroughly understood prior to use of any medical or assistive device. If
ambiguities exist, they should be clarified.
Most medical and assistive devices provide the manufacturer's contact information, such as a toll-free
number or website. Keeping this information handy makes it easier to investigate problems or ask
questions.
Resource Tips
Health professionals in the related field (e.g., respiratory technologists for inhalation devices, occupational
therapists for home safety equipment and assistive devices).
Organizations such as the Victorian Order of Nurses (VON) for in-home support of some types of medical
and assistive devices.
Retailers and manufacturers—including mail order, Internet and sports accessory retailers—may specialize
in medical and assistive devices.
The Lung Association has instructional videos on correct use of inhalers and other respiratory devices.
Available from: www.lung.ca/lung-health/get-help/how-use-your-inhaler.
Support Groups:
The Amyotrophic Lateral Sclerosis Society of Canada. 3000 Steeles Avenue East, Suite 200, Markham, ON
L3R 4T9. 1-800-267-4257. Available from: www.als.ca.
The Arthritis Society. 393 University Avenue, Suite 1700, Toronto, ON M5G 1E6. 1-800-321-1433. Available
from: www.arthritis.ca.
Easter Seals Canada. 40 Holly Street, Suite 401, Toronto, ON M4S 3C3. 416-932-8382. Available from:
www.easterseals.ca.
The Lung Association. 1750 Courtwood Crescent, Suite 300, Ottawa, ON K2C 2B5. 613-569-6411; 1-888-566-
5864. Available from: www.lung.ca.
The Multiple Sclerosis Society of Canada. 250 Dundas Street West, Suite 500, Toronto, ON M5T 2Z5. 416-
922-6065; 1-800-268-7582. Available from: www.mssociety.ca.
Spinal Cord Injury Canada. 130 Albert Street, Suite 512, Ottawa, ON K1P 5G4. 613-723-1913. Available from:
www.sci-can.ca.
References
1. Industry Canada. Canadian Life Science Industries. Medical devices. Medical device industry profile
2013. Available from: www.ic.gc.ca/eic/site/lsg-pdsv.nsf/eng/h_hn01736.html. Accessed April 28,
2016.
2. Canada. Department of Justice. Food and Drugs Act, R.S. 1985, c. F-27, section 2.
3. Canada. Department of Justice. Medical Devices Regulations, SOR/98-282, section 1.
4. Statistics Canada. Body composition of adults, 2012 to 2013. 2014. Available from:
www.statcan.gc.ca/pub/82-625-x/2014001/article/14104-eng.htm. Accessed March 23, 2015.
5. Public Health Agency of Canada. The facts: seniors and injury in Canada. 2011. Available from:
www.phac-aspc.gc.ca/seniors-aines/publications/public/injury-blessure/safelive-securite/chap2-
Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions
Myla E. Moretti, MSc, PhD

Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions

To view the complete table in a new window, please click on the “Printable Version” link.
Table 1: Pregnancy and Breastfeeding: Self-care Therapy for Common Conditions

For comparative ingredients of nonprescription products, consult the Compendium of Products for Minor Ailments.
Indication Self-care Drugs of Choice in Pregnancy Alternatives in Pregnancy Self-care Drugs of Alternatives in Comments
Choice in Breastfeeding Breastfeeding
Acne benzoyl peroxide1,2 benzoyl peroxide2 Topical tretinoin is

See also Acne. believed to be
nonteratogenic
and systemic
bioavailability is
low; however,
continuing use in
pregnancy may
not be warranted.3
Allergic Rhinitis Second-generation antihistamines: desloratadine, First- or second- See Nasal

See also Allergic cetirizine4,5,6 generation Congestion if
fexofenadine17,18,19 antihistamine
Rhinitis and antihistamines20,21,22,23
loratadine7,8,9,10,11 alone is
Prenatal and
Postpartum Care. First generation antihistamines: inadequate.
brompheniramine,12
chlorpheniramine,
doxylamine,
diphenhydramine,
pheniramine13,14,15,16
Backache/ acetaminophen15,16,24,25,26 acetaminophen Avoid NSAIDs in

headache/ ASA15,27,28,29,30,31,32,33,34,35 the third
ASA,
fever/pain (with or without codeine16) ibuprofen, trimester.36,37,38
codeine,
See also Fever, naproxen Limit codeine to
Headache, Low ibuprofen,
See comments short-term use in
Back Pain and naproxen pregnancy.
Prenatal and
Postpartum Care. Limit codeine in
breastfeeding to
short-term use (<4
days) in patients
for whom safer
effective
treatments are
unavailable.
Discontinue
codeine if either
mother or infant
displays signs of
toxicity.24,39
Chest Congestion guaifenesin15,16,27 guaifenesin No data on

See also Acute excretion into milk;
Cough, Prenatal however, not
and Postpartum expected to pose
Care. a risk to suckling
infant.
Cold Sores No
See also Cold nonprescription
Sores (Herpes therapy of choice;
Labialis). prescription
therapy may be
preferred.a
Conjunctivitis, See Comments Though

allergic absorption of
See also many
Assessment of nonprescription
Patients with Eye eye drops is
Conditions and minimal,
Conjunctivitis. prescription
products may
have more
evidence of safety
in pregnancy.
Conjunctivitis, See Comments Though

infectious absorption of
See also many
Assessment of nonprescription
Patients with Eye eye drops is
Conditions and minimal,
Conjunctivitis. prescription
products may
have more
evidence of safety
in pregnancy.
Constipation Bulk-forming agents: psyllium, bran See Comments magnesium hydroxide senna Glycerin
See also Stool softeners: docusate Bulk-forming agents: suppositories and
Constipation and psyllium, bran polyethylene
Prenatal and glycol (PEG) are
Stool softeners: acceptable for
Postpartum Care. docusate, bisacodyl short-term use in
acute constipation
during pregnancy.
Senna and other
stimulants may
induce uterine
contractions and
bowel dependence
—only short-term
use is advised.
Cough dextromethorphan,15,16,40,41 dextromethorphan codeine No data on

See also Acute excretion of
codeine dextromethorphan
Cough and
Prenatal and into milk; however,
Postpartum Care. not expected to
pose a risk to
suckling infant.
Limit codeine to
short-term use in
pregnancy.
Limit codeine in
breastfeeding to
patients for whom
safer effective
treatments are
unavailable and
limit to short-term
use (<4 days).
Discontinue
codeine if either
mother or infant
displays signs of
toxicity.24,39
Dandruff coal tar preparations, coal tar preparations, Not studied in

See also Dandruff pyrithione zinc pyrithione zinc human pregnancy
and Seborrheic or lactation;
Dermatitis. however, systemic
absorption is
expected to be
negligible.
Dermatitis See Comments Nonprescription topical Though

See also Atopic, corticosteroids (if used nonprescription
Contact, and on nipple or areola, wipe topical
Stasis Dermatitis. off prior to feeding). corticosteroids are
Water-based products probably safe,
preferred. appropriate
medical
assessment is
recommended to
identify potential
pregnancy-specific
dermatologic
conditions.
Diarrhea attapulgite/kaolin + pectin27 bismuth subsalicylate,27 attapulgite/kaolin + Avoid salicylate-

See also Diarrhea. pectin27 containing
psyllium15,16,27,42 loperamide27,43 compounds in the
See Comments psyllium15,16,27,42 third trimester.
loperamide27,43
Fungal Infections, No
mouth nonprescription
See also Oral therapy of choice.a
Candidiasis. Patient requires
further
assessment
and/or treatment.
Fungal Infections, No
nails nonprescription
See also Fungal therapy of choice.a
Nail Infections Patient requires
(Onychomycosis). further
assessment
and/or treatment.
Fungal Infections, clotrimazole, clotrimazole, Though these

skin miconazole, miconazole, nystatin topical antifungal
See also Fungal (topical) agents are
nystatin considered safe,
Skin Infections.
(topical) further
assessment is
See Comments
recommended to
identify potential
pregnancy-specific
dermatologic
conditions.
Fungal Infections, clotrimazole (topical, vaginal) fluconazole clotrimazole (topical, fluconazole Patient requires
vaginal 150 mg single dose vaginal) 150 mg single further
miconazole (topical, vaginal)44,45,46 dose assessment
See also Vaginal miconazole (topical,
Symptoms, and/or treatment
vaginal)47 if symptoms
Hygiene and
Infections. persevere after
nonprescription
treatment.
A single study
found elevated
risk for
spontaneous
abortion with
fluconazole;48
whenever
possible, limit use
to second half of
pregnancy.
Gingivitis/ See Comments See Comments No

periodontitis nonprescription
See also therapy of choice.a
Periodontal Consult dentist for
Conditions: a diagnosis and
Gingivitis and appropriate
Periodontitis. treatment
recommendations.
Hemorrhoids Bulk-forming agents: psyllium, bran See Comments Bulk-forming agents: See Comments No safety data
See also Stool softeners: docusate psyllium, bran available for
Hemorrhoids, Stool softeners: nonprescription
Topical: zinc oxide topical hemorrhoid
Prenatal and docusate
Postpartum Care. products; however,
Topical: zinc oxide because of the
small doses and
limited systemic
absorption, they
can be safely used
for symptom relief
if bulk-forming
agents and stool
softeners are
inadequate.
Influenza Treat symptoms

See also Viral and hydration as
Rhinitis, Influenza, necessary, see
Sinusitis and individual
Pharyngitis. symptoms.
Insect Bites and Treatment with ice may be sufficient diphenhydramine (oral or Treatment with ice may diphenhydramine Patient requires
Stings topical), be sufficient (oral or topical), further
See also Insect Nonprescription topical Nonprescription assessment
Bites and Stings. corticosteroids topical and/or treatment
corticosteroids if symptoms are
severe or do not
resolve within 7
days.
Topical
diphenhydramine
can cause allergic
contact
dermatitis.
Insect Repellents See Comments See Comments Use products with

See also Insect <30% DEET when
Bites and Stings. protective clothing
is not sufficient.
Lice permethrins,49,50 pyrethrins with piperonyl permethrins, Not studied in

See also Parasitic butoxide pyrethrins with piperonyl lactation; however,
Skin Infections: butoxide systemic
Lice and Scabies. absorption is
expected to be
negligible.
Nasal Congestion pseudoephedrine,31,32,53,54 Topical nasal saline nasal spray/drops pseudoephedrine Some sources
See also Allergic See Comments decongestants: Topical nasal (See comments) recommend
Rhinitis and oxymetazoline, avoidance of
saline nasal spray/drops decongestants: pseudoephedrine
Prenatal and xylometazoline,15,42,53
oxymetazoline, during the first
Postpartum Care.
phenylephrine 16,33,55,57 xylometazoline15,42,53 trimester based on
a single, small
study showing
increased risk of
gastroschisis;30
however, a recent
larger study from
the same group
did not show
increased risk.56
Though not
reported in
humans,
phenylephrine is
more likely than
pseudoephedrine
to produce
vasoactive effects
such as
hypertension and
reduced uterine
blood flow.
There may be a
risk of decreased
milk production
with
pseudoephedrine
in women whose
lactation is not
well established or
who have low milk
supply.
Nausea and doxylamine/pyridoxine58 dimenhydrinate16,59,60,61 dimenhydrinate Doxylamine 10

Vomiting mg/pyridoxine 10
See also Nausea mg (delayed-
and Vomiting and release
Prenatal and combination
Postpartum Care. product) is
available on
prescription.
Pharyngitis acetaminophen, ASA,15,27,35 naproxen acetaminophen, ASA, Short-term use for

See also Viral See comments codeine, pain relief is safe.
codeine, Avoid NSAIDs in
Rhinitis, Influenza, ibuprofen,
Sinusitis and ibuprofen third trimester.
Pharyngitis. See comments naproxen Limit codeine to
short-term use in
pregnancy.
Limit codeine in
breastfeeding to
short-term (<4
days) use in
patients for whom
safer effective
treatments are
unavailable.
Discontinue
codeine if either
mother or infant
displays signs of
toxicity.24,39
Patient requires
further
assessment as
bacterial infection
may require
prescription
treatment.
Pigmentary hydroquinone hydroquinone Minimal human

changes See Comments See Comments data do not
(chloasma, suggest
melasma) teratogenic risk;51
See also however, as
Prevention and treatment is
Treatment of Sun- cosmetic only, use
induced Skin should be avoided.
Damage. Systemic
absorption does
occur.52
Sunscreen use
can help to
prevent or
minimize
pigmentary
changes.
Pinworms See Comments See Comments Published safety

See also data exist only for
Pinworms. prescription
agents and
therefore they are
preferred for this
indication.
However, there are
no published
reports of adverse
outcomes in
pregnancy or
breastfeeding
associated with
pyrantel pamoate.
Reflux alginic acid compounds, aluminum, alginic acid compounds,

Esophagitis calcium and magnesium antacids, aluminum, calcium and
See also famotidine, magnesium antacids,
Dyspepsia and famotidine,
GERD and omeprazole62,63,64
Prenatal and ranitidine omeprazole65
Postpartum Care. ranitidine
Rhinorrhea First-generation antihistamines: First-generation

See also Allergic brompheniramine,12 antihistamines20,21,22,23
Rhinitis, Viral
Rhinitis, Influenza, chlorpheniramine,
Sinusitis and doxylamine,
Pharyngitis and diphenhydramine,
Prenatal and
Postpartum Care. pheniramine13,14,15,16
Scabies permethrins49,50 permethrins Not studied in

See also Parasitic lactation; however,
Skin Infections: systemic
Lice and Scabies. absorption is
expected to be
negligible.
Smoking nicotine replacement (patch, gum, nicotine replacement Nicotine

Cessation inhaler) (patch, gum, inhaler) replacement has
See also Smoking not been well
Cessation. studied in
pregnancy or
lactation but
would provide less
toxin exposure for
the patient than
cigarette smoke.
The addition of
counselling may
improve cessation
success rate.
Viral Rhinitis See Nasal Congestion

See also Viral See Rhinorrhea
Rhinitis, Influenza,
Sinusitis and
Pharyngitis.
Warts, common salicylic salicylic acid Avoid salicylates

or plantar acidpreparations15,27,28,29,30,31,32,33,34,35 preparations in the third
See also Plantar trimester.
Warts and Viral
Skin Infections:
Common and Flat
Warts.
a
For many conditions only prescription treatments have been studied. This does not mean that nonprescription therapy is unsafe, but there is no evidence available on
which to base a recommendation at this time. For further information on prescription treatment, consult the Compendium of Therapeutic Choices.
References
1. Rothman KF, Pochi PE. Use of oral and topical agents for acne in pregnancy. J Am Acad Dermatol 1988;19:431-42.
2. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin 2006;24:167-97, vi.
3. Kaplan YC, Ozsarfati J, Etwel F et al. Pregnancy outcomes following first-trimester exposure to topical retinoids: a systematic review and meta-analysis.
Br J Dermatol 2015;173:1132-41.
4. Einarson A, Bailey B, Jung G et al. Prospective controlled study of hydroxyzine and cetirizine in pregnancy. Ann Allergy Asthma Immunol 1997;78:183-6.
5. Wilton LV, Pearce GL, Martin RM et al. The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England. Br J
Obstet Gynaecol 1998;105:882-9.
6. Weber-Schoendorfer C, Schaefer C. The safety of cetirizine during pregnancy. A prospective observational cohort study. Reprod Toxicol 2008;26:19-23.
7. Moretti ME, Caprara D, Coutinho CJ et al. Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study. J Allergy Clin Immunol
2003;111:479-83.
8. Diav-Citrin O, Shechtman S, Aharonovich A et al. Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled
cohort study. J Allergy Clin Immunol 2003;111:1239-43.
9. Gilbert C, Mazzotta P, Loebstein R et al. Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review. Drug Saf 2005;28:707-19.
10. Kallen B, Olausson PO. No increased risk of infant hypospadias after maternal use of loratadine in early pregnancy. Int J Med Sci 2006;3:106-7.
11. Schwarz EB, Moretti ME, Nayak S et al. Risk of hypospadias in offspring of women using loratadine during pregnancy: a systematic review and meta-
analysis. Drug Saf 2008;31:775-88.
12. Seto A, Einarson T, Koren G. Evaluation of brompheniramine safety in pregnancy. Reprod Toxicol 1993;7:393-5.
13. Seto A, Einarson T, Koren G. Pregnancy outcome following first trimester exposure to antihistamines: meta-analysis. Am J Perinatol 1997;14:119-24.
14. McKeigue PM, Lamm SH, Linn S et al. Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. Teratology 1994;50:27-37.
15. Aselton P, Jick H, Milunsky A et al. First-trimester drug use and congenital disorders. Obstet Gynecol 1985;65:451-5.
16. Heinonen OP, Shapiro S, Slone D. Birth defects and drugs in pregnancy. Littleton: Publishing Sciences Group; 1977.
17. Schatz M, Petitti D. Antihistamines and pregnancy. Ann Allergy Asthma Immunol 1997;78:157-9.
18. Schick B, Hom M, Librizzi R et al. Terfenadine (Seldane) exposure in early pregnancy. Teratology 1994;49:417.
19. Loebstein R, Lalkin A, Addis A et al. Pregnancy outcome after gestational exposure to terfenadine: a multicenter, prospective controlled study. J Allergy
Clin Immunol 1999;104:953-6.
20. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet
Gynecol 1993;168:1393-9.
21. Findlay JW, Butz RF, Sailstad JM et al. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol 1984;18:901-
6.
22. Lucas BD, Purdy CY, Scarim SK et al. Terfenadine pharmacokinetics in breast milk in lactating women. Clin Pharmacol Ther 1995;57:398-402.
23. Hilbert J, Radwanski E, Affrime MB et al. Excretion of loratadine in human breast milk. J Clin Pharmacol 1988;28:234-9.
24. Rebordosa C, Kogevinas M, Horvath-Puho E et al. Acetaminophen use during pregnancy: effects on risk for congenital abnormalities. Am J Obstet
Gynecol 2008;198:178.e1-7.
25. Streissguth AP, Treder RP, Barr HM et al. Aspirin and acetaminophen use by pregnant women and subsequent child IQ and attention decrements.
Teratology 1987;35:211-9.
26. Smith J, Taddio A, Koren G. Drugs of choice for pregnant women. In: Koren G, ed. Maternal-fetal toxicology: a clinician's guide. 2nd ed. New York: Marcel
Dekker; 1994. p. 115-28.
27. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. 9th ed. Philadelphia: Wolters Kluwer
Health; Lippincott Williams & Wilkins; 2011.
28. Barry WS, Meinzinger MM, Howse CR. Ibuprofen overdose and exposure in utero: results from a postmarketing voluntary reporting system. Am J Med
1984;77:35-9.
29. Slone D, Siskind V, Heinonen OP et al. Aspirin and congenital malformations. Lancet 1976;1:1373-5.
30. Werler MM, Mitchell AA, Shapiro S. First trimester maternal medication use in relation to gastroschisis. Teratology 1992;45:361-7.
31. Torfs CP, Katz EA, Bateson TF et al. Maternal medications and environmental exposures as risk factors for gastroschisis. Teratology 1996;54:84-92.
32. Werler MM, Sheehan JE, Mitchell AA. Maternal medication use and risks of gastroschisis and small intestinal atresia. Am J Epidemiol 2002;155:26-31.
33. Zierler S, Rothman KJ. Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy. N Engl J Med 1985;313:347-
52.
34. Werler MM, Mitchell AA, Shapiro S. The relation of aspirin use during the first trimester of pregnancy to congenital cardiac defects. N Engl J Med
1989;321:1639-42.
35. Zierler S. Maternal drugs and congenital heart disease. Obstet Gynecol 1985;65:155-65.
36. Levin DL. Effects of inhibition of prostaglandin synthesis on fetal development, oxygenation, and the fetal circulation. Semin Perinatol 1980;4:35-44.
Nutritional Supplements
L. Maria Gutschi, BScPhm, PharmD

Peer Review Date: March 2016
Introduction
Vitamins and minerals cannot usually be synthesized in the body but occur naturally in certain foods. They are essential in small quantities for normal body metabolism,
functioning as cofactors within enzyme systems required for the function of life. Some vitamins such as A and D serve in hormonal or epigenetic pathways. If steady
intakes are not met, deficiency diseases occur, which can sometimes lead to death. However, excess intake can result in toxicities, even at doses which were generally
thought to be safe. Most individuals in North America ingest sufficient vitamins and minerals in their diets to prevent deficiency diseases; a small number may be at risk
and require supplementation of particular nutrients for identified deficiencies. Insufficient vitamin D levels may be common in Canadians due to our northern climate
since it is derived primarily from exposure to sunlight.
Nutritional supplements are defined as consumable health products that contain a nutrient or group of nutrients (vitamins, minerals, protein, carbohydrates, fats and oils)
which occur naturally in food and which are required for normal functioning of the body. They are intended to supplement but not substitute for a healthy diet. Nutrient
supplementation can contribute to overall health and vitality, providing sufficient vitamins, minerals and other nutrients for prevention of deficiency diseases. Although
preliminary studies may suggest that nutrient supplementation prevents or reduces risk of chronic disease, a benefit is yet to be proven by large trials in most cases.
Additionally, long-term nutrient supplementation may be harmful.
Chronic intake of some drugs can affect or interact with vitamins and minerals. Depending on the nature of interaction, it may be necessary to avoid combination therapy,
or drug therapy may necessitate supplementation.
Dietary Reference Intakes for Nutrients

The Dietary Reference Intakes (DRIs) are a comprehensive set of nutrient reference values for healthy populations that can be used for assessing and planning diets.1,2
Established cooperatively by Canada and the United States, DRIs are derived from scientific data and provide a range of values from optimal to maximum based on
indicators of good health, prevention of chronic disease and evaluation of the possible adverse effects of excess intake. The DRI encompasses the reference values
described below.
The Estimated Average Requirement (EAR) is the median usual intake value that is estimated to meet the requirement of half the healthy individuals in a life-stage and
gender group. At this level of intake, the other half of the individuals in the specified group would not have their needs met. The EAR is based on a specific criterion of
adequacy, derived from a careful review of the literature. Reduction of disease risk is considered along with many other health parameters in the selection of that criterion.
The EAR is used to calculate the Recommended Dietary Allowance (RDA).1,2 RDA is defined as the average daily dietary intake level thought to be sufficient to meet the
nutrient requirement of nearly all (97–98%) healthy individuals in a particular life stage and gender group.2
The Adequate Intake (AI) is a recommended average daily nutrient intake level based on observed/experimentally determined estimates of nutrient intake by a group (or
groups) of apparently healthy people who are assumed to be maintaining an adequate nutritional state. The AI is used when there are insufficient data to establish the
estimated average requirement on which to base the RDA of a nutrient. It is expected to meet or exceed the needs of most people in the age, gender or life-stage group.2
A diet with nutrient content below 10% of the EAR is considered the threshold for inadequate intake.3 Nutritional deficiency refers to an inadequate supply of a particular
nutrient that results in illness or disease and is corrected by supplementation of the deficient nutrient. Nutritional deficiency may be the result of inadequate dietary intake
or impairment of digestion, absorption, transport or metabolism.
Table 1 provides selected DRIs for common nutrients. Table 2 provides information on the roles, food sources, deficiency states and toxicity related to excess intake of the
fat-soluble vitamins (A, D, E and K). Table 3 provides information on the roles, food sources, deficiency states and toxicity related to excess intake of the water-soluble
vitamins: thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), biotin (B7), folic acid (B9), cyanocobalamin (B12) and ascorbic acid (C). Choline, while not a
vitamin, is an essential nutrient usually grouped with the B-complex vitamins. Table 4 provides information on selected essential minerals. Macrominerals (with
requirements measured in mg to g per day) include calcium, magnesium, phosphorous, potassium and sodium while microminerals (with requirements measured in µg to
mg per day) include copper, chromium, fluoride, iodine, iron, manganese, molybdenum, selenium, vanadium and zinc.
Goals of Therapy
Identify and correct any nutritional deficiencies (Table 5)
Tailor supplementation to individual and specific diets
Ensure excess is not consumed and limit antioxidant supplementation
Ensure no significant drug-nutrient interactions (Table 6)
Assess benefit vs. risk in individual patients for prevention or treatment of disease (Table 7)
Treatment of a disease or condition with micronutrient supplementation should be supported by good evidence and monitored for adverse events.
Indications for General Preventive Supplementation
A benefit from micronutrient supplementation is unlikely for most of the general adult population;4 encourage consumption of whole foods such as fruits, vegetables,
whole grains, legumes, nuts and fish as these may contain other important nutrients required for optimal health (e.g., phytochemicals such as flavonoids,
isothiocyanates, isoflavones, saponins) and have been shown to decrease risk of chronic disease and mortality.5,6 Clarity regarding the potential mortality benefit of
supplementation with specific nutrients (e.g., vitamin D and omega-3 fatty acids/fish oils) awaits more evidence from prospective randomized controlled trials.7 Most
Canadians have adequate intake of micronutrients although deficiencies in vitamin A, vitamin C, vitamin D, calcium, magnesium, zinc and folate have been identified in
high-risk groups (e.g., those at the lowest level of income and/or education).8 See Table 5 for a discussion of common deficiencies.
Certain groups of individuals may require specific preventive supplementation.
Conditions with increased requirements:
Pregnancy and breastfeeding

folic acid: pregnant and breastfeeding women require a folic acid supplement in addition to a diet of folate-rich foods. The recommended supplemental
dosage is based upon the female's or male partner's risk for a neural tube defect or other folic acid–sensitive congenital anomaly:9
low risk: 0.4 mg/day beginning at least 2–3 months before conception and continuing until 4–6 weeks postpartum or as long as breastfeeding
continues
moderate risk: 1 mg/day beginning at least 3 months before conception and continuing until 12 weeks' gestational age; then 0.4–1 mg/day until 4–6
weeks postpartum or as long as breastfeeding continues
high risk: 4 mg/day beginning at least 3 months before conception and continuing until 12 weeks' gestational age; then 0.4–1 mg/day until 4–6 weeks
postpartum or as long as breastfeeding continues
calcium: (intake from dietary sources recommended but many people do not ingest enough) 1300 mg/day for women ≤18 years; 1000 mg/day for those
≥19 years2
vitamin D: 600 IU/day;2 consider 2000 IU/day for pregnant women during winter months10
iron: if supplementation required, recommended dosage is 27 mg/day.2,11 Routine iron supplementation during pregnancy in nonanemic women
(hemoglobin >130 g/L) may not be without adverse effects12 and 16 mg/day total supplementation is proposed.13 Intermittent iron supplementation (± folic
acid) may be an alternative for preventing gestational anemia in nonanemic women with adequate antenatal care. Intermittent supplementation is less likely
to result in adverse events such as nausea and GI disturbances compared with a daily regimen, and results in similar maternal and infant outcomes.14
Additionally, the risk of high hemoglobin concentrations may be reduced. The most commonly used intermittent dosing schedule is 120 mg weekly
elemental iron, given on 1 day of the week in 2 divided doses. This regimen is not recommended for women who are anemic at the start of their
pregnancy.14
Drug-nutrient interactions (see Table 6).
Conditions with risk of inadequate intake:
Very low calorie diet (<800 kcal/day), either voluntary or involuntary (overall insufficient intake)
Exclusion diets—lack intake of certain foods, e.g., whole grains, deeply coloured vegetables and fruits, fortified cereals, animal-source foods
vegan diets:15,16 vitamin B12, vitamin D, calcium, omega-3 fatty acids (EPA/DHA), iron and zinc
lacto-ovo vegetarian diets:15,17 omega-3 fatty acids (EPA/DHA), iron and zinc
Chronic substance abuse (in particular for alcohol abuse): vitamin C, vitamin B1, folic acid, vitamin B6 and vitamin B2 (riboflavin)1
Poverty, social isolation, institutionalization:18 vitamin A, vitamin C, magnesium, calcium, folic acid, vitamin B12 and vitamin D
At-risk elderly (possibly due to polypharmacy, poor oral health, functional limitations, depression, dementia, social isolation): encourage increased oral intake to
manage insufficient micronutrient intake.19,20 Vitamin B12 deficiency (primarily due to chronic food-cobalamin malabsorption and to a lesser extent pernicious
anemia)21 and vitamin D deficiency are common in this group and may require supplementation
routine vitamin and mineral supplementation may be associated with increased mortality in elderly women, particularly supplemental iron.22
Supplementation is not associated with a decreased risk of infections in elderly persons living at home23
Children with severely restricted eating patterns.24,25
Conditions with risk of malabsorption:
Bariatric surgery: vitamins A, D, K, B1, B12, C and folic acid; calcium, copper, iron, selenium, and zinc. Patients require routine supplementation with vitamins and
minerals for 2 years or more, with doses higher than those provided by nonprescription supplements26,27
GI diseases known to cause malabsorption or maldigestion (e.g., lactose intolerance, gluten-sensitive enteropathy, food allergies): fat-soluble vitamins, vitamin
B12, vitamin K, zinc, iron, calcium
Swallowing, chewing or dental problems.
Daily Dietary Reference Intakes for Vitamins and Selected Minerals
1,2
Table 1: Daily Dietary Reference Intakes for Vitamins and Selected Minerals
Vitamins Minerals
Pantothenic Biotina Folateb

Age, Gender A B1 B2 B3 Acida (B5) B6 (B7) (B9) B12 C D E Ka Caa Fe Fa Se Zn
or Life Stage (IU) (mg) (mg) (mg) (mg) (mg) (µg) (µg) (µg) (mg) (IU) (mg) (µg) (mg) (mg) (mg) (µg) (mg)
0–6 monthsa 1333 0.2 0.3 2 1.7 0.1 5 65 0.4 40 400 4 2 200 0.27 0.01 15 2
7–12 1667 0.3 0.4 4 1.8 0.3 6 80 0.5 50 400 5 2.5 260 11c 0.5 20 3c
monthsa
1–3 y 1000 0.5 0.5 6 2 0.5 8 150 0.9 15 600 6 30 700 7 0.7 20 3
4–8 y 1333 0.6 0.6 8 3 0.6 12 200 1.2 25 600 7 55 1000 10 1 30 5
9–13 y 2000 0.9 0.9 12 4 1.0 20 300 1.8 45 600 11 60 1300 8 2 40 8
14–18 y Male 3000 1.2 1.3 16 5 1.3 25 400 2.4 75 600 15 75 1300 11 3 55 11
14–18 y 2333 1.0 1.0 14 5 1.2 25 400d 2.4 65 600 15 75 1300 15 3 55 9

Female
14–18 y 2500 1.4 1.4 18 6 1.9 30 600d 2.6 80 600 15 75 1300 27 3 60 12

Pregnancy
14–18 y 4000 1.4 1.6 17 7 2.0 35 500 2.8 115 600 19 75 1300 10 3 70 13
Breastfeeding
19–50 y Male 3000 1.2 1.3 16 5 1.3 30 400 2.4 90 600 15 120 1000 8 4 55 11
Vitamins Minerals
Pantothenic Biotina Folateb

Age, Gender A B1 B2 B3 Acida (B5) B6 (B7) (B9) B12 C D E Ka Caa Fe Fa Se Zn
or Life Stage (IU) (mg) (mg) (mg) (mg) (mg) (µg) (µg) (µg) (mg) (IU) (mg) (µg) (mg) (mg) (mg) (µg) (mg)
19–50 y 2333 1.1 1.1 14 5 1.3 30 400d 2.4 75 600 15 90 1000 18 3 55 8

Female
19–50 y 2567 1.4 1.4 18 6 1.9 30 600d 2.6 85 600 15 90 1000 27 3 60 11

Pregnancy
19–50 y 4333 1.4 1.6 17 7 2 35 500 2.8 120 600 19 90 1000 9 3 70 12

Breastfeeding
51–70 y Male 3000 1.2 1.3 16 5 1.7 30 400 2.4 90 600 15 120 1000 8 4 55 11
51–70 y 2333 1.1 1.1 14 5 1.5 30 400 2.4 75 600 15 90 1200 8 3 55 8

Female
≥71 y Male 3000 1.2 1.3 16 5 1.7 30 400 2.4 90 800 15 120 1200 8 4 55 11
≥71 y Female 2333 1.1 1.1 14 5 1.5 30 400 2.4 75 800 15 90 1200 8 3 55 8
a
RDA unknown; values represent AI.
b As dietary folate equivalents DFE (1 DFE = 1 µg folate from food = 0.5 µg folic acid supplement taken on an empty stomach = 0.6 µg from a fortified food or a supplement consumed
with food).
c
Value represents RDA.
d All women capable of becoming pregnant should take a supplement of 400 µg of folic acid daily, in addition to the amount of folate found in a healthy diet; this supplement should
continue until a pregnancy is confirmed and prenatal care begins. The critical time for neural tube formation is shortly after conception.
Abbreviations: AI = adequate intake; Ca = calcium; F = fluoride; Fe = iron; RDA = recommended dietary allowance; Se = selenium; Zn = zinc
Fat-soluble Vitamins
1,2,28
Table 2: Fat-soluble Vitamins
Nutrient Role and Sources Deficiency State Toxicity Prevention of Toxicity
vitamin A Required for vision, bone Deficiency rare, but inadequate TUL: 10 000 IU/day. Avoid supplementation of
(retinol) growth, reproduction, cell intake of retinol reported in 35% Teratogenic at doses preformed vitamin A
division, cell differentiation. of Canadians ≥19 years of age2 >10 000 IU/day. (retinol) in populations not
Regulates immune system at risk for deficiency.
and gene transcription. Abnormal visual adaptation to Hepatotoxic.
Encourage dietary intake
darkness:29,30 High intake of preformed
Food sources (preformed from vegetables and fruits
Changes in conjunctiva vitamin A through diet or
vitamin A): Liver, fish oils, as there is no evidence of
called Bitot spots supplementation may be
whole milk, eggs, fortified increased osteoporosis risk
food products. Severe deficiency causes associated with from dietary intake.
blindness osteoporosis and fracture
Food sources (provitamin
A): Leafy green vegetables, Dry skin, hair and eyes29,30 risk;31 can occur
orange and yellow Broken fingernails subclinically without signs
vegetables, tomato or symptoms of
Decreased resistance to
products, fruits. hypervitaminosis at total
infections (diarrhea and
doses of 5000 IU/day; risk
measles)29,30 may be highest in those
Papillary hyperkeratosis of the with low vitamin D intake.32
skin29,30
Patients/populations at risk of
Vitamin A deficiency:1
recent immigrants or
refugees from developing
countries with high
incidence of vitamin A
deficiency or measles
patients with Crohn’s
disease
patients with celiac disease
patients with pancreatic
diseases
beta-carotene Food sources No TUL established for No RDA established, but
(carotenoids): Coloured dietary beta-carotene.33 3–6 mg/day recommended.
fruits and vegetables. Supplementation with beta-
Oral beta-carotene
supplements increase risk carotene not generally
of first-time nonfatal MI, required but may be used
increase risk of CV for patients/populations at
risk of vitamin A deficiency
mortality34,35 in adult male
(see Vitamin A).
smokers; increase risk of
lung cancer diagnosis and High serum concentrations
death in patients at high of alpha-carotene (also
risk.35 found in yellow-orange and
dark green vegetables) are
Vitamin A and beta- associated with decreased
carotene supplementation,
risk of mortality.36
singly or combined,
increase risk of overall Lycopene, lutein and
mortality.33 zeaxanthin are carotenoids
which do not have vitamin A
activity but have health
promoting activity.
vitamin D Modulates transcription of Insufficiency and deficiency TUL: 4000 IU/day. Cholecalciferol (vitamin D3)
(D3: cholecalciferol >50 genes in cell common in Canadians (see Hypercalcemia, most useful in primary care.
differentiation, immunity, Table 5) hypercalciuria, reversible
D2: ergocalciferol) Avoid large single doses
insulin secretion, renal impairment, GI
hypertension. Children:37 (10 000 IU or more).
Rickets (costochondral symptoms.
Total amounts of vitamin D
Required for calcium beading, epiphyseal Single yearly high doses ingestion from various
metabolism. enlargement, bowed legs, (500 000 IU orally or supplements should be
Food sources: Salmon, persistently open anterior 300 000 IU IM) have been recorded/monitored.
sardines, tuna and fish oils, fontanelle) associated with increased
fortified milk/orange juice, risk of falls and fracture
Adults:37
some mushrooms. rates especially in the first
Osteomalacia/osteoporosis
Sunlight (activates 7- months post-dose.38
dehydrocholesterol in the 400 IU/day plus 2 g/day of
skin). calcium was associated
with small increased risk of
nephrolithiasis.39
Persons with primary
hyperparathyroidism,
sarcoidosis, tuberculosis
and lymphoma may have
increased risk of
hypercalcemia with
supplementation.
vitamin E Required as an antioxidant Children:40 TUL: 1000 mg (1500 Little or no supplementation

(α-tocopherol) for protection from Hemolytic anemia in IU)/day. in patients with a history of
damaging effects of free premature infants and GI upset at doses of 200– stroke, CABG surgery, MI or
radicals. newborns 800 mg/day, antiplatelet those at risk of prostate
Food sources: Nuts, seeds, effects and bleeding at cancer. Limit vitamin E
Hyporeflexia
vegetable oils, egg yolk, 800–1200 mg/day. Other supplementation for others
Spinocerebellar and retinal to <400 IU/day.
wheat germ, fortified or degeneration toxicity can occur at
enriched grain products. 1200 mg/day (emotional Ensure no significant drug-
Adults (rare):40 disturbances, nutrient interactions which
Overt deficiency syndromes thrombophlebitis, lipid and can increase bleeding risk
in adults have never been thyroid effects, gonadal (see Table 6).
described dysfunction).41
Intervention trials have not
supported the hypothesis
that vitamin E decreases CV
risk42,43 or prevents
cancer.42,44
Vitamin E supplementation:
showed a small
increased risk of heart
failure in people at
high risk of CVD44
may increase risk of
death from any cause
at doses >400
IU/day45
has no significant
effect on the incidence
or number of days of
respiratory infections
or antibiotic use46
may increase risk of
prostate cancer47
vitamin K Required for blood clotting Neonates (common):48,49 TUL has not been Single ingredient oral
and bone formation. prolonged bleeding and determined. supplements are not
Food sources: Green leafy prothrombin time, available in Canada.
vegetables, vegetable oils. hemorrhagic Excess intake of vitamin K
manifestations in newborns from food sources may
interfere with the effect of
Adults (uncommon):49
vitamin K antagonist
unexpected or excessive
anticoagulants, e.g.,
bleeding
warfarin.
Risk factors:
alcohol abuse
general malnutrition
malabsorption states
disseminated intravascular
coagulation
parencymal liver disease
polycythemia vera
Abbreviations: AI = adequate intake, established when evidence is insufficient to develop an RDA; is set at a level assumed to ensure nutritional adequacy; CABG = coronary artery
bypass graft; CV = cardiovascular; CVD = cardiovascular disease; RDA = recommended dietary allowance, i.e., average daily level of intake sufficient to meet the nutrient requirements of
nearly all (97–98%) healthy individuals; TUL = tolerable upper limit, i.e., maximum average daily intake likely to cause no risk of adverse health effects
Water-soluble Vitamins
1,2,28
Table 3: Water-soluble Vitamins
Prevention of
Nutrient Role and Sources Deficiency State Toxicity Toxicity
vitamin B1 Required coenzyme for Beriberi (wet): TUL has not been
mitochondrial enzymes High-output cardiac failure determined.
(thiamine)
involved in critical roles Palpitations, weakness, SOB
in the production of
Beriberi (dry):
energy from food.
Peripheral neuropathy (burning feet syndrome)
Food sources: Wide Absent knee jerk and deep tendon reflexes
variety of foods
Progressive weakness and muscle atrophy
including cereals (rice,
wheat), legumes, nuts, Sensory disturbances occur first followed by motor
wheat germ, pork. disturbances
Wernicke syndrome (CNS involvement occurs in alcohol
abusers):
Confusion
Ataxia
Nystagmus
Risk factors:
Malabsoption/malnutrition
Prolonged dieting
Weight loss surgery
Alcohol abuse
Long-term diuretic use; heart failure50
Dialysis51
Treatment with thiamine as the initial test is used to
diagnose deficiency
vitamin B2 Integral component of Deficiency rarely found in isolation. Signs/symptoms TUL has not been
flavoenzymes required include: determined.
(riboflavin)
for redox reactions and Cheilosis
metabolism of Angular stomatitis
carbohydrates, fats and Glossitis
proteins.
Seborrheic dermatitis
Food sources: Wide Corneal vascularization
variety of foods
Photophobia
including fortified
cereals, milk and milk Riboflavin deficiency may predispose pregnant women to
products, meat, eggs, preeclampsia
nuts. Risk factors:
Alcohol abuse
Hypothyrodism or adrenal insufficiency
Lactose intolerance
Malabsorptive states
Pregnancy and lactation
End stage renal disease, dialysis51
Prevention of
vitamin B3 Required to produce Pellagra: TUL: 35 mg/day Limit routine

hemoglobin and to Dermatitis (thick scaly pigmented rash in areas Prostaglandin- supplementation
(niacin, nicotinic
increase its oxygen- exposed to sunlight) mediated flushing to <30 mg/day.
acid,
carrying capacity. Helps Diarrhea and inflammation of mouth and tongue occurs in doses Treatment of
niacinamide)
maintain blood glucose (glossitis) >30 mg/day (itching, lipid disorders
levels in normal range. Dementia (apathy, disorientation, memory loss) increased intracranial requires larger
Food sources: Wide Also: blood flow, headache). doses and
variety of foods Sensitivity to sunlight Use of large doses should be
including beans, meats, Aggressiveness (>3 g/day) may cause monitored by a
cereals, vegetables. elevated liver enzyme clinician.
Insomnia
Weakness levels and is a risk
factor for jaundice and
Ataxia
hepatotoxicity (more
Risk factors: common with
Diets high in corn and low in protein sustained-release
Anorexia nervosa or obesity formulations), GI
symptoms, impaired
Dialysis51
glucose tolerance.
Homelessness
Alcoholism
HIV/AIDS
vitamin B5 Component of Deficiency exceptionally rare TUL has not been

coenzyme A which is determined.
(pantothenic
required to produce
acid)
energy from food.
Food sources: Liver,
kidney, yeast, egg yolk,
legumes, broccoli.
vitamin B6 Has role in production Severe deficiency uncommon TUL: 100 mg/day Avoid high-dose
of >100 enzymes Inadequacy associated with: Sensory neuropathy supplementation.
(pyridoxine)
required for chemical Microcytic anemia with progressive ataxia
reactions, e.g., glycogen can occur with high-
Seborrhoeic skin lesions,
phosphorylation. dose supplementation
Convulsions
Food sources: Fortified (100–500 mg/day);
Irritability, nervousness, insomnia
cereals, poultry, reversible upon
potatoes, spinach, Peripheral neuropathy (distal limb numbness appears discontinuation.
avocados, bananas, early, distal limb paresthesia or burning foot syndrome
occurs later) Supplementation to
nuts. reduce
Pyridoxine neuropathy occurs in both deficiency and hyperhomocysteinemia
toxicity states and subsequent
Deficiency also leads to hyperhomocysteinemia atherosclerosis has
been disappointing.
Risk factors:
Sickle cell disease
Malnutrition and malabsorption
Dialysis
Rheumatoid arthritis
Treatment with isoniazide, hydralazine, pyrazinamide
Alcohol abuse
vitamin B7 Required for Deficiency exceptionally rare TUL has not been
mammalian determined.
(biotin)
carboxylase enzymes.
Food sources: Egg
yolks, liver, yeast,
bananas, grapefruit,
watermelon, most
vegetables.
Prevention of
folic acid Required for new cell Megaloblastic anemia TUL: 1000 µg/day Studies
growth formation and Adverse fetal outcomes: Doses >1500 µg/day demonstrate
(folate)a maintenance, especially mixed results
Neural tube defects can cause irritability,
during periods of rapid confusion, regarding
Orofacial clefts
growth. exacerbation of seizure unmetabolized
Cardiovascular malformations folic acid or
Food sources: Legumes frequency, precipitate
(cooked kidney, pinto, Risk factors: or exacerbate vitamin intracellular
fava beans), green leafy Anorexia nervosa B12 deficiency. folate and
vegetables (spinach), Malabsorption increased cancer
Potential increase in
liver, fortified flour Alcohol abuse and CV risk;52,56
CV risk and colon
(mandatory in Canada), more study is
Hyperthyroidism cancer52,53 and
fortified breakfast required to
Pregnancy and lactation chronic high doses delineate risk-
cereals, oranges.
Dialysis51 may increase risk of benefit profile.
solid cancers.54 Avoid
Increased rate of supplements
cognitive decline in unless higher
elderly who take large folate need is
doses is possibly identified (e.g.,
related to low vitamin pregnancy,
B12 levels.55 breastfeeding,
methotrexate
use).
Limit total
supplement
intake to ≤0.4
mg/day.
Emphasize foods
high in folate
(e.g., green leafy
vegetables,
fruits) as intake
from foods is not
associated with
adverse effects.
vitamin B12 Required for red blood Pernicious anemia TUL has not been
cell formation, DNA Neurologic deterioration: determined.
(cyanocobalamin)
synthesis and Peripheral neuropathy
neurological function.
Cognitive impairment
Food sources: Meat,
fish, shellfish, eggs, Deficiency common in Canada57 (see Table 6)
poultry, fortified cereals.
choline Although not a vitamin, TUL: 3.5 g/day

choline is an essential Ingestion of 7.5 g/day
nutrient for structural may cause
integrity of cell hypotension.
membranes, cholinergic Cholinergic signs
neurotransmission, and (sweating and
lipid and cholesterol diarrhea) and a fishy
transport and body odour may occur
metabolism. with doses of
Accelerates synthesis
and release of 10–16 g/day.58
acetylcholine.
Food sources: Milk, liver,
eggs, peanuts; small
amounts are
synthesized in humans
from phospholipids.
Dietary sources provide
approximately 730–
1040 mg/day of choline,
mostly as lecithin
(phosphatidylcholine).58
Prevention of
vitamin C Required for collagen Chronic severe deficiency results in scurvy (rare) TUL: 2 g/day Limit
(ascorbic acid) formation, l-carnitine Early presentation: Several grams taken at supplementation
and protein synthesis. Malaise and lethargy once can cause to <2 g/day.
Maintains integrity of Irritability nausea, vomiting,
skin, connective tissue, Dry mouth and eyes esophagitis and
bone, blood vessel walls heartburn, flushing and
and dentine. Skin changes include perifollicular hemorrhages, corkscrew diarrhea. Sleep
hairs disturbances and
Required for wound
healing and recovery Purpura/ecchymoses seen on legs or buttocks fatigue have also been
from burns. Splinter hemorrhages reported.
Vitamin C is an Bleeding gums, friability, tooth loss Long-term ingestion of

important physiological Anemia and high output heart failure seen late in the 2 g/day may
antioxidant and disease precipitate urate or
regenerates other oxalate stones in the
Fractures, bleeding into muscles and joints
antioxidants including urinary tract and
Risk factors: increase risk of
vitamin E.
Receiving only cow’s milk during first year of life nephrolithiasis.59
Food sources: Fruits Alcoholism
(especially citrus),
Elderly
vegetables (peppers).
Low income
Smoking
Increased need in pregnancy and lactation,
thyrotoxicoses, burns, insulin deficiency
Dialysis51
Anorexia nervosa or anorexia due to cancer or HIV
infection
Fad diets or severely restricted eating patterns
Depletion can occur within 1–3 months; fatal if untreated
but prevention requires only 35 mg/day
a Folate refers to the form found naturally in foods; folic acid is the synthetic form used in fortified foods and supplements.
Abbreviations: AI = adequate intake, established when evidence is insufficient to develop an RDA; is set at a level assumed to ensure nutritional adequacy; CV = cardiovascular; RDA
= recommended dietary allowance, i.e., average daily level of intake sufficient to meet the nutrient requirements of nearly all (97–98%) healthy individuals; SOB = shortness of
breath; TUL = tolerable upper limit, i.e., maximum average daily intake likely to cause no risk of adverse health effects
Selected Macro- and Microminerals

1
Table 4: Selected Macro- and Microminerals
Nutrient Sources Toxicity Management
calcium Food sources: TUL: 2500 mg/day Typical diet provides 500–1000 mg elemental
Dairy Studies demonstrated mixed results concerning increased risk of calcium/day; avoid total amounts (from diet and oral
products, cardiac events, particularly MI, if excess calcium supplementation is supplements) >1.2 g/day.
calcium-set Ensure adequate vitamin D intake.
tofu, fortified used with or without vitamin D.60,61,62,63,64
foods, kale Calcium intake of >2 g/day (dietary or supplement) may be
and related associated with increased risk of prostate cancer.65
greens
(broccoli, bok More trials required to determine if there is a risk of calcium
choy, supplementation, especially in persons with adequate dietary
cabbage). calcium intake.
Deficiency not
uncommon in
selected
patient
groups in
Canada (see
Table 5).
irona Food sources TUL: 45 mg/day Avoid supplementation unless prescribed for known or
(heme iron Excess iron is stored in tissues and organs, e.g., liver, heart and may suspected iron deficiency or for increased need.
from lead to cirrhosis, heart failure. Absorption of nonheme iron, e.g., from plant sources,
hemoglobin): may be influenced by enhancers (ascorbic or malic acid)
Meat, poultry, Iron is extremely toxic in overdose; accidental poisoning/death has
or inhibitors (polyphenols, phytates, soy protein).
fish. occurred in children with ingestion of as little as 200 mg.66
Deficiency not
uncommon in
selected
patient
groups in
Canada (see
Table 5).
Nutrient Sources Toxicity Management
magnesium Food sources: TUL: 350 mg/day Average intake is generally less than recommended,
Green leafy Acute: doses of >5 g are associated with hypotension, nausea, however low dietary intake does not generally result in
vegetables; vomiting, facial flushing leading to muscle weakness, breathing symptomatic magnesium deficiency.
nuts, seeds, difficulties, cardiac arrythmias (plasma levels >1.74–2.61 mmol/L). Toxicity risks increased with impaired renal function.
whole grains,
foods high in Chronic: high doses from supplementation/medications may cause
fibre. diarrhea, nausea, cramping.
potassium Food sources: TUL has not been determined for healthy adults. Routine supplementation of potassium is not
Fruits and Doses >11 g as a single dose may lead to hyperkalemia in persons recommended.
vegetables, who are not accustomed to high intakes even if there is normal For more information on hyperkalemia, see Potassium
especially kidney function. Acute or chronic renal failure, excessive aldosterone Disturbances.
tropical fruits, secretion and medications (e.g., potassium-sparing diuretics, ACEIs,
baked ARBs, SMX/TMP) increase risk of hyperkalemia.
potatoes with
skin.
selenium Food sources: TUL: 400 µg/day

Organ meats, Selenosis (hair and nail brittleness and loss, gastrointestinal upset,
seafood;
plant sources garlic breath odour, fatigue, irritability and mild neuropathy) is rare.1
dependent on Cases were reported in 13 subjects taking supplements which, due
selenium to a manufacturing error, contained 27.3 mg (27 300 µg) per tablet.67
content of
soil.
Average diet
provides
approximately
100 µg/day.
zinc Food sources: TUL: 40 mg/day Avoid high-dose supplementation.

Shellfish, red Acute: Nausea, vomiting, anorexia, abdominal cramps. Monitor persons on high doses of zinc for treatment of
meat, nuts, macular degeneration for genitourinary effects (urinary
legumes. Chronic: Doses 150–450 mg/day affect copper status, alter iron
function, decrease immune function, decrease HDL. retention, UTI, urinary lithiasis).
Doses >80 mg/day as used in the AREDS study have been For more information, see Age-related Macular
associated with significant increase in genitourinary Degeneration.
hospitalizations.68
a
RDAs are given as doses of elemental iron. Requirements are 1.8 times higher in vegetarians due to the lower bioavailability of iron from a vegetarian diet.
Abbreviations: AI = adequate intake, established when evidence is insufficient to develop an RDA; is set at a level assumed to ensure nutritional adequacy; ARB = angiotensin II receptor
blocker; AREDS = Age-Related Eye Disease Study; HDL = high-density lipoprotein; RDA = recommended dietary allowance, i.e., average daily level of intake sufficient to meet the nutrient
requirements of nearly all (97–98%) healthy individuals; SMX/TMP = sulfamethoxazole/trimethoprim; TUL = tolerable upper limit, i.e., maximum average daily intake likely to cause no
risk of adverse health effects; UTI = urinary tract infection
Supplementation to Prevent or Treat Common Known Deficiency States

Table 5: Supplementation to Prevent or Treat Common Deficiency States
Deficiency Patient Groups Affected Recommendations
vitamin D (cholecalciferol) Approximately 10% of Canadians have Health Canada RDA (Table 1) differs from those of other groups:
inadequate levels for bone health and are at
Adequate levels:a >50 nmol/L risk for rickets or osteomalacia; 60% have Osteoporosis Canada80 recommends routine vitamin D
Deficiency (<25 nmol/L) may be supplementation for all Canadian adults year round:
levels <75 nmol/L,78 the suggested level
associated with muscle pain, bone pain needed for overall health and disease Adults 19–50 y (including pregnant or breastfeeding women):
Suboptimal levels (25–75 nmol/L) may prevention. 400–1000 IU daily
be associated with:69,70 Patient groups at increased risk of Adults >50 y and those at high risk:c 800–2000 IU daily
Decreased bone health, deficiency/suboptimal levels include:69 International Osteoporosis Foundation81
osteoporosis Dark-skinned individuals
Older adults: 800–1000 IU/day
Increased CV risk Lack of sunlight due to northern latitude,
Obese, limited sun exposure, non-European populations: 2000
use of occlusive clothing, staying indoors
Muscle weakness and falls IU/day
(e.g., elderly, obese or institutionalized
Increased risk of cognitive decline persons) Canadian Cancer Society82
in the elderly,71 schizophrenia,72 Medication-induced (see Table 6). Adults during fall and winter months: 1000 IU/day
type I diabetes, depression, cancer
(colon, possibly breast and Modest decrease in overall mortality, primarily Adults ≥ 50 y, dark skin or little sun exposure: 1000 IU/day all
prostate), cancer mortality, seen in elderly women who are year round
multiple sclerosis
institutionalized or in dependent care.79 Canadian Pediatric Society83
Evidence from observational studies
Pregnancy and breastfeeding: Consider 2000 IU/day,
suggests an association between low
serum vitamin D and all-cause and especially during winter monthsd
cardiovascular mortality.73,74 Large Maintenance range: 400–2000 IU/day
randomized controlled trials are Evidence and safety supports use of 800–1000 IU/day in
required to determine whether vitamin D Canadians.
supplementation mitigates this
For severe deficiency (levels <25 nmol/L), consider bolus dosing
risk.75,76 followed by maintenance:
Measurement of vitamin D levels is not 2000–4000 IU of D3 daily for 8–20 wk or
routinely requiredb unless high risk of
600 000 IU of D2 over 8 wk (e.g., 50 000 IU weekly for 8–12
deficiency or concerns regarding
wk)69
toxicity77
Optimal form of vitamin D and regimen for bolus dosing for severe
deficiency have not been established.
Appropriate vitamin D levels may improve dietary absorption of
calcium.69,84
vitamin B12 Persons with macrocytosis or neurologic For treatment of pernicious anemia, see Common Anemias.
symptoms. Encourage persons at risk of vitamin B12 deficiency to consume
Pernicious anemia occurs in 2–4% of
US population; overall rate of vitamin Persons >60 y (marginal depletion reported to foods high in vitamin B12.
B12 insufficiency is estimated at 1.5– be >20%).86 Malabsorption of vitamin B12 from food is the main cause of
15%85 Persons with gastric, ileal, pancreatic, Crohn's, deficiency in the elderly.
or celiac disease. Consider 1000 µg/day orally for persons taking drugs known to
Chronic use of PPIs, metformin or H2 receptor deplete vitamin B12 stores.
antagonists.
Exclusion diets.87
calcium Postmenopausal women.88 In postmenopausal women, ≤400 IU vitamin D and ≤1000 mg of

calcium supplements provided no benefit for the primary
Vegans or those who limit dairy product intake
(e.g., due to lactose intolerance). prevention of fractures;90 high quality evidence for the benefit of
higher doses of vitamin D is lacking but 800–2000 IU/day is often
Persons with anorexia or excess exercise
recommended.88 Excess calcium supplementation should be
leading to amenorrhea.89
avoided (limit to ≤1200 mg/day from all sources).88
Calcium carbonate should be taken with food to improve
absorption; calcium citrate can be taken without food and is more
readily absorbable. Avoid doses >500 mg elemental calcium at one
time.
Constipation, gas or bloating may be managed with smaller, more
frequent dosing, or differing formulations or salts.
Vegans and others who limit dairy intake can also obtain adequate
dietary calcium through foods such as beans, tofu, nuts, fortified
nut or soy beverages, blackstrap molasses, and a variety of
vegetables including low-oxalate greens (e.g., bok choy, broccoli,
Chinese cabbage, collards, and kale).15,91
iron Female adolescents, women with heavy Adult men and postmenopausal women should not take a
menstrual losses. supplement unless evaluated, as deficiency is rare and
Those at high risk of malabsorption (e.g., supplementation may be harmful.22
Crohn's or celiac disease). Vegetarians/vegans should consider consuming nonheme sources
Patients with renal failure, especially those on of iron together with foods high in vitamin C (e.g., citrus fruits) to
dialysis. improve absorption.
Persons who engage in intense aerobic
exercise; female and vegetarian/vegan
athletes; distance runners may also be at
risk.66
a
Evidence of the relationship between disease due to vitamin D insufficiency and 25-hydroxyvitamin D levels is evolving.
b Excludes patients with conditions such as osteoporosis, rickets, osteopenia, malabsorption syndromes and renal disease or those taking drugs that affect vitamin D metabolism.
c High-risk adults are those with osteoporosis, multiple fractures or conditions affecting vitamin D absorption.
d
The effectiveness of this regimen and possible side effects should be checked with periodic assays for 25(OH)D and calcium.
Abbreviations: CV = cardiovascular; IU = international unit; PPI = proton pump inhibitor; RDA = recommended dietary allowance; SPF = sun protection factor
Clinically Significant Drug-Nutritional Supplement Interactions

41,92
Table 6: Clinically Significant Drug–Nutritional Supplement Interactions
Supplement Drug Interaction Management
beta- Hepatotoxic drugs May increase risk of liver disease. Avoid combination.
carotene, (acetaminophen,
vitamin A carbamazepine,
isoniazid,
methotrexate)
Retinoids Additive toxic effects. Avoid combination.

(isotretinoin,
acitretin,
etretinate,
tazarotene)
Warfarin Increased risk of vitamin A toxicity and bleeding. Avoid combination.
calcium Diuretics Possible hypocalcemia (with loop diuretics) or May require calcium supplementation with loop diuretics.
hypercalcemia (with thiazides).
Fluoroquinolones, Decreased absorption, possible decreased efficacy, risk Separate calcium doses at least 4 h apart from
tetracyclines, of treatment failure. bisphosphonates; consider temporarily discontinuing
bisphosphonates, supplementation while receiving fluoroquinolones or
glucocorticoids tetracyclines. Normal dairy intake is unlikely to decrease
efficacy.
folic acid Methotrexate Increased folate requirements to prevent GI and liver Supplement with 1–5 mg/day; avoid on days when
(low-dose) toxicity. methotrexate ingested.
Phenytoin Folic acid may be a cofactor in phenytoin metabolism, Avoid folic acid supplements >1 mg/day.
decrease serum phenytoin levels with large doses of
folic acid and potential increase in seizure frequency.
iron Allopurinol Increased iron storage in liver. Avoid combination.
Bisphosphonates, Form insoluble complexes with iron. Separate doses at least 2 h apart. Avoid iron and levodopa
fluoroquinolones, combination.
levothyroxine,
levodopa,
tetracyclines
PPIs,93 H2 Decrease absorption of nonheme iron, retard clinical May require change to heme iron formulation if iron-deficiency
antagonists response to iron supplementation. anemia occurs on chronic PPI therapy.
Separate doses at least 2 h apart.
magnesium Bisphosphonates, Forms insoluble complexes; results in reduced Separate doses by at least 2 h.
tetracyclines absorption.
Diuretics Loop/thiazide diuretics: Possible magnesium depletion. Regular monitoring of magnesium levels required.
Potassium-sparing diuretics: Reduced magnesium
excretion.
PPIs94 Chronic long-term use of PPIs may cause Periodic monitoring suggested.
hypomagnesemia. Supplements may be required.
Possibly accompanied by hypocalcemia and
hypokalemia.
niacin Antihyperglycemic Impairs glucose tolerance in a dose-dependent manner. Doses >4 g/day may increase plasma glucose by an average
agents of 16% and HbA1c by 21%; increased requirements for
antihyperglycemic agents may be necessary.
Carbamazepine Niacin 60–80 mg/day may increase carbamazepine Monitor carbamazepine levels, avoid niacin supplementation.
levels.
Statins Increased risk of myopathies. Monitor signs and symptoms, use lowest dose possible.
pyridoxine Antiepileptic Can decrease phenytoin and phenobarbital serum levels Discontinue pyridoxine or increase dose of antiepileptic drug.
(vitamin B6) drugs (phenytoin, by increasing metabolism.
phenobarbital)
Isoniazid Acts as an antagonist and can induce peripheral Supplementation recommended but limit pyridoxine to 10–50
neuropathy. mg/day.
Supplement Drug Interaction Management
Levodopa Decreased anti-parkinson effect. Avoid supplementation; consider treatment with
levodopa/carbidopa combination.
vitamin B12 H2 blockers Possible decreased vitamin B12 levels but evidence is
conflicting.
Metformin 10–30% of patients who take metformin may have Supplementation of crystalline vitamin B12 may be required.
decreased vitamin B12 absorption.
PPIs93 Reduce absorption (probably by inhibiting intragastric Supplementation of crystalline vitamin B12 may be required,
proteolysis and the release of vitamin B12 from food). especially in the elderly or if on PPI >10 y.
vitamin D Antiepileptic Increased vitamin D metabolism to inactive compounds Supplementation may be required.
drugs and decreased calcium absorption.
(carbamazepine,
phenytoin,
phenobarbital)
Cholestyramine, Decreased absorption. Supplementation may be required.

colestipol, orlistat
Corticosteroids Can impair vitamin D metabolism; long-term use can Supplementation may be required.
contribute to development of osteoporosis as
corticosteroids also inhibit calcium absorption.
Rifampin Increased vitamin D metabolism. Supplementation may be required.
vitamin E Warfarin, ASA, May increase risk of bleeding. Limit vitamin E dose to ≤200 IU/day and monitor INR.
NSAIDs
Abbreviations: HbA1c = hemoglobin A1c; INR = International Normalized Ratio; NSAID = nonsteroidal anti-inflammatory drug; PPI = proton pump inhibitor
Evidence-based Supplementation to Prevent or Treat Disease

Table 7: Evidence-based Supplementation to Prevent or Treat Disease
Disease/Condition Supplement Evidence of Benefit/Risk Recommendations
Age-related macular antioxidants plus copper and May be beneficial; data primarily from AREDS95 Discuss supplementation with specialist/family
degeneration zinc in patients with age-related macular physician since data are not available for other
degeneration (AMD). The addition of lutein and patient groups.
zeaxanthin or omega-3 fatty acids to the original Beta-carotene–containing formulations are no
AREDS formula did not demonstrate reduced longer recommended for prevention of AMD
risk of progression of AMD.96 progression because of an increased risk of lung
For treatment of age-related macular cancer.96
degeneration, see Age-related Macular Lutein and zeaxanthin may be a suitable
Degeneration. replacement for beta-carotene in the original
AREDS formulation.
Cardiovascular omega-3 fatty acids Benefits of fatty fish/omega-3 fatty acid 2 servings weekly of low-mercury fish (tuna,
disease, primary supplementation have been questioned.97,98 sardines, salmon) recommended.
prevention May consider supplementation to provide 1 g/day
Definitive benefits to be determined in upcoming
trials. of EPA+DHAa in those who do not consume fish.
Persons with sensitivity to finned fish appear to
tolerate fish oil supplements;99 alternatively a
DHA supplement derived from algae may be used
for vegetarians, vegans or those with severe
allergies.
vitamin D Supplementation in older patients (>70 y) with Vitamin D supplementation is unlikely beneficial
isolated systolic hypertension did not improve for primary prevention of cardiovascular disease.
blood pressure, despite baseline low 25-
hydroxyvitamin D levels.100
Dosing of 100 000 IU/3 months may be a study
limitation.
folic acid Folic acid in combination with enalapril appears Persons with the lowest baseline folate levels
to reduce the risk of first stroke in persons with benefitted the most.
hypertension but without established CVD.101 Applicability to the Canadian population with
mandatory folic acid fortification program is
uncertain.
Cardiovascular B vitamins (folic acid, vitamin No benefit seen on CV events with B vitamins Avoid routine use.
disease, secondary B6, vitamin B12) and and potential harm from
prevention antioxidants antioxidants.102,103,104,105
omega-3 fatty acids Modest reduction in CV mortality and 1 g/day (EPA+DHA).a,109

hospitalization in patients with mild to severe HF
Formulation of omega-3 acid ethyl esters used in
and reduced EF.106 trials (Omacor/Lovanza) is not yet available in
No benefit seen if post-MI patients optimally Canada.
treated107 or given low doses.108 Routine supplementation with omega-3 fatty acid
Lack of benefit seen when initiated after acute capsules no longer recommended for secondary
phase of CV event.102 prevention of MI, but is unlikely to cause harm;110
≥2 servings of oily fish weekly as part of a
Lack of benefit for prevention of recurrent AF.111
Mediterranean diet for secondary prevention of MI
also unlikely to harm.110
Monitor INR if on warfarin.
Cancer prevention, folic acid 1 mg/day in high-risk patients with polyps not Avoid supplementation for cancer prevention
colon effective in reducing colon cancer112 and may especially in those at high risk; increasing folate
increase risk. from dietary sources may be beneficial.
Supplementation in the general population does
not appear to be beneficial.113
calcium, vitamin D Additional studies are needed on use of calcium,

vitamin D before these can be routinely
recommended.
antioxidants Avoid antioxidant supplementation.33,114
Cancer prevention, vitamin E Long-term vitamin E supplementation does not Limit or avoid vitamin E supplementation,
other prevent cancer.115 Supplementation increases especially in those at high risk (e.g., smokers).
risk of prostate cancer by 17%; effect is apparent Avoid in males, especially those >60 y.
by the third year of supplementation.47
selenium Selenium supplementation does not prevent Limit supplementation for primary prevention of
cancer.47 cancer.
B vitamins (folic acid, vitamin Vitamin B supplementation does not decrease Limit supplementation for primary prevention of
B6, vitamin B12) overall risk of breast cancer.116 breast cancer.
beta-carotene Beta-carotene supplements increase risk of Avoid beta-carotene, retinol especially in those at
gastric and lung cancer at doses of high risk (smokers); supplement with foods high
20–30 mg/day and at any dose in patients at in alpha-carotenes.36
high risk (smokers, asbestos exposure).105,117
vitamin D Benefit of vitamin D for cancer prevention Canadian Cancer Society recommends:
awaiting clarification from definitive trials as Adults during fall and winter months: 1000
data are conflicting (possible increased risk of IU/day
pancreatic cancer with high vitamin D levels).118 Adults ≥ 50 y, dark skin or little sun exposure:
1000 IU/day all year round82
Cancer prevention, niacinamide High-risk patients (i.e., ≥ 2 nonmelanoma skin 500 mg niacinamide (vitamin B3) twice daily; not
secondary, skin cancers in previous 5 y) had significant reduction niacin.119
in the rate of development of new skin
cancers.119 Rebound effect seen if treatment discontinued.119
Childhood omega-3 fatty acids Maternal supplementation with omega-3 fatty More studies required.
development acids during pregnancy did not result in
(cognitive and visual) significant differences in cognitive or visual
development.120,121
Supplementation of formula-fed infants with
omega-3 fatty acids may improve cognitive
development.122
Cognitive decline B vitamins (folic acid, vitamin Supplementation with B vitamins123 or Avoid high-dose vitamin B and antioxidant
B6, vitamin B12) and antioxidants (vitamin C, vitamin E, beta- supplementation.
antioxidants
carotene)124 does not prevent cognitive decline.
omega-3 fatty acids/fish oil Insufficient data to recommend omega-3 fatty A possible decreased risk with fish consumption
acid supplementation to prevent cognitive has been seen in observational trials.124
decline.
Diabetes omega-3 fatty acids Omega-3 fatty acids lower triglycerides and Awaiting controlled clinical trial data to support
VLDL but have no effect on glycemic control; observational data.
LDL levels may increase insignificantly.
Insufficient data to make recommendations for
diabetes prevention.125
vitamin D Risk of type 1 diabetes may be decreased in No change to current recommendations until RCT
children who were supplemented—may prevent evidence is available.
type 1 diabetes.126 Data are insufficient to recommend vitamin D for
primary prevention of type 2 diabetes or for
glycemic control.
B vitamins (folic acid, vitamin High-dose vitamin B therapy (folic acid, vitamin Avoid supplementation.
B6, vitamin B12) B6 and vitamin B12) did not slow progression of
diabetic nephropathy and increased risk of
vascular events.127
Gout vitamin C Vitamin C supplementation (median dose of 500 Limit doses to <2 g/day.
mg per day) modestly decreased serum uric acid More study required to determine optimal dose
levels in healthy patients,128 but a small RCT did and effect on clinical outcomes (number of gouty
not show any urate-lowering effects in patients attacks).
with gout.129
Headache omega-3 fatty acids Dietary intervention of increased n-3 EPA and Unknown if supplementation will result in similar
DHA and decreased n-6 LA intake decreased the outcomes. Larger confirmatory trials needed
number and intensity of headaches and before recommendation can be made.
increased quality of life.132 For more information, see Headache.
Heart failure omega-3 fatty acids May be considered in those with mild to 1 g daily of EPA+DHA.a
moderate heart failure.130 The formulation of omega-3 acid ethyl esters used
Those with preserved EF >40% may not benefit. in trials (Omacor/Lovanza) is not available in
Canada.
Monitor for increased bleeding if on warfarin.
Doses >3 g/day may be associated with bleeding.
coenzyme Q10 Supplementation has no effect on exercise Higher quality studies required to determine if
capacity or LV function in patients with heart there are benefits on morbidity or mortality when
failure despite increased blood levels.131 added to current standard of care.
Mood disorders B vitamins (folic acid, vitamin Limited data suggest potential benefit, especially Supplementation with vitamin B6 25 mg, vitamin
(major depressive B6 and vitamin B12) in women when used as adjunctive therapy.133 B12 500 µg and folic acid 2 mg daily may be
disorder) considered as adjuvant therapy in patients
Supplemental B vitamins may increase rates of
receiving antidepressants, or for stroke patients at
remission with antidepressant therapy in middle-
risk of depression.
aged and older adults.134
Balance potential benefit of folic acid
Supplemental vitamin B6, B12 and folic acid supplementation with long-term risk. Uncertain
decrease risk of depression after stroke or whether benefit occurs in those with or without
TIA.135 folate deficiency.
Short-term folic acid augmentation as
monotherapy may not provide benefit.136,137
omega-3 fatty acids/fish oil Data primarily as adjunctive therapy at doses of More studies required. For more information, see
1–4 g/day; EPA alone or with DHA appears to Depression.
show greater benefits.a,133
Fish oil supplementation during pregnancy does
not reduce risk of postpartum depression and
has not been shown to improve
neurodevelopment in offspring.121,138,139
selenium Insufficient evidence for the use of selenium to More studies required.
prevent postpartum depression.139
Pain, chronic or vitamin D One trial has shown a beneficial effect of Recommendation regarding use of vitamin D to
neuropathic supplementation with vitamin D in chronic pain decrease incidence of chronic pain awaits high
conditions.140 quality trial evidence.141
Pregnancy-related calcium Oral calcium may prevent pre-eclampsia and 1 g daily in divided doses may be beneficial,
conditions and decrease risk of death or complications related especially for women with low baseline calcium
pregnancy outcomes to hypertension.142 intake or at high risk of pre-eclampsia.
folic acid There is strong evidence to suggest that 0.4 mg/day via a daily multivitamin is
prophylactic therapy with folic acid, prior to and recommended for all women of child-bearing
during pregnancy, reduces the risk of fetal neural potential.9
tube defects.
SOGC makes specific supplementation
Preconception supplementation with folic acid recommendations based upon risk of neural tube
significantly reduces the risk of neonate being
defects:9
small for gestational age.143 Low-risk: Supplement 0.4 mg/day beginning
at least 2–3 months before conception and
continuing until 4–6 weeks postpartum or as
long as breastfeeding continues
Moderate-risk: Supplement 1 mg/day
beginning at least 3 months before
conception and continuing until 12 weeks'
gestational age; then supplement 0.4–1
mg/day until 4–6 weeks postpartum or as
long as breastfeeding continues
High-risk: Supplement 4 mg/day beginning at
least 3 months before conception and
continuing until 12 weeks' gestational age;
then supplement 0.4–1 mg/day until 4–6
weeks postpartum or as long as
breastfeeding continues.
magnesium Magnesium supplementation during pregnancy No evidence to recommend supplementation.

does not reduce risk of perinatal mortality, small-
for-gestational-age newborns or maternal pre-
eclampsia.144
vitamin D Observational studies suggest an association Consider recommending 2000 IU/day for pregnant
between maternal vitamin D levels and offspring women during winter months.83
birthweight, bone mass and serum calcium
concentrations. More studies are required to
provide evidence of benefit of supplementation
during pregnancy.145
Psychotic disorders/ omega-3 fatty acids/fish oil May be beneficial for early prevention in persons Requires confirmatory trials.
schizophrenia at ultra-high risk of psychosis.146
May allow decreased antipsychotic doses, but
its use for treatment of schizophrenia remains
experimental.147
Little evidence of benefit for manic symptoms of
bipolar disorder.148
folic acid Supplementation improved negative symptoms Folic acid 2 mg and vitamin B12 400 µg may be
in patients with specific gene variants beneficial in those with FOLH1 gene variants.
(FOLH1).149
Respiratory vitamin C Limited evidence that vitamin C may decrease Vitamin C prophylaxis may have a small, but
conditions pneumonia incidence and decrease respiratory consistent effect on the duration of symptoms of
symptoms; benefits seen in those at high risk of the common cold. Children in particular may
or known to have malnutrition/insufficient benefit.151
intake.150
Vitamin C supplementation halves the risk of a
common cold in persons who are under extreme
physical stress for short periods of time (e.g.,
marathon runners, skiers, soldiers in subarctic
conditions). No benefit seen for duration or
severity of cold.151
Vitamin C prophylaxis is not beneficial in
reducing incidence of the common cold in the
general population.151
zinc Zinc lozenges may reduce the duration of the Zinc lozenges ≥75 mg/day for the duration of the
common cold when administered within 24 cold is the recommended dose.
hours of onset of symptoms.152
Rheumatologic omega-3 fatty acids/fish oil Supplementation with fish oil as adjunct to 5.5 g/day of EPA+DHAa in liquid form.
conditions DMARD therapy may significantly increase the
Monitor for GI disturbances, burping; potential
remission rate in early RA.153 increased risk of bleeding.
vitamin D Supplementation with vitamin D 2000 IU Vitamin D supplementation may be beneficial, but
improved inflammatory and hemostatic markers larger trials required before routine
as well as disease activity in patients with SLE supplementation can be recommended.
and vitamin D insufficiency.154
Triglyceridemia omega-3 fatty acids Efficacy appears similar to fibrates.155 2–4 g/day of EPA+DHAa supplements in capsule
form.
Monitor for GI disturbances, burping; potential
increased risk of bleeding.
a EPA and DHA are essential fatty acids found in cold water fish.
Abbreviations: AF = atrial fibrillation; AREDS = Age-Related Eye Disease Study; CVD = cardiovascular disease; DHA = docosahexaenoic acid; DMARD = disease-modifying antirheumatic
drug; EF = ejection fraction; EPA = eicosapentaenoic acid; FOLH1 = folate hydrolase 1; HF = heart failure; INR = international normalized ratio; LA = linoleic acid; LDL = low-density
lipoprotein; LV = left ventricular; RA = rheumatoid arthritis; RCT = randomized controlled trial; SLE = systemic lupus erythematosus; SOGC = Society of Obstetricians and Gynaecologists
of Canada; TIA = transient ischemic attack; VLDL = very-low-density lipoprotein
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CTMA 2

Canada’s Trusted Reference for

Sample Chapters for Conference_J.indd 1 6/17/2016 2:35:16 PM

Communicating With Patients

Central Nervous System Conditions

Sample Chapters for Conference_J.indd 3 6/17/2016 2:35:16 PM

Metabolic and Cardiovascular Conditions

Sample Chapters for Conference_J.indd 4 6/17/2016 2:35:17 PM

Reproductive, Gynecologic and Genitourinary Health

Sample Chapters for Conference_J.indd 5 6/17/2016 2:35:17 PM

Sample Chapters for Conference_J.indd 6 6/17/2016 2:35:18 PM

Barbara J. Farrell, BScPhm, PharmD

Assessment and Triage

Table 1: Question Appropriately

Table 2: Speak at an Appropriate Language Level

A lot of phlegm Productive Digestive system Gastrointestinal

High blood pressure Hypertension Lower Decrease

Painkiller Analgesic Raise Increase or elevate

Cough suppressant Antitussive Condition Diagnosis

Shooting pain Radiating pain How bad Severity

Bum Rectum On the skin Topically

Table 3: Listen Effectively

Make an effort to understand how the Judgmental or critical responses (You

angry? weak or sick? worried? in pain?

Figure 2: What to Say when Counselling Patients

Table 6: Speaking Skills

Table 7: Verbal Skills to Use Over the Telephone

Start with a friendly greeting

Table 8: Nonverbal Skills to Use During Telephone Conversations

Be prepared Put the patient on hold

Tips for Special Situations

Minimize your contribution to the “off topic”

Tips for interacting with the angry patient:

Tips for interacting with the depressed/upset/crying patient:

Offer privacy, tissues, time alone

Determine preferences before recommending a product

Tips for interacting with the patient with hearing impairment:

Ask if the patient can hear you

Tips for interacting with the patient with vision impairment:

Tips for interacting with the patient with cognitive impairment:

Tips for interacting with the noncommunicative patient:

Wait during silence so the patient can respond

Tips for interacting with the elderly patient:

Tips for interacting with the patient with speech impairment:

Speak slowly and simply

Tips for interacting with the caregiver:

Provide written information for the patient

National Association of Pharmacy Regulatory Authorities. Professional competencies for Canadian

Lisa Dolovich, BSc Phm, PharmD, MSc

The Transtheoretical Model of Behaviour Change

This theory encompasses and integrates 5 core components:

Abbreviations: Cons = disadvantages; Pros = beneﬁts

Patient Assessment to Identify Stages of Change

Consciousness-raising Precontemplation and

Dramatic relief Precontemplation and

Environmental re-evaluation Precontemplation and

Self re-evaluation Contemplation

Social liberation Contemplation and preparation

Helping relationships Preparation, action and