Introduction to Biology

Exploring Life

Elif Sibel Aslan

 Introduction
• Biology, the study of life, is rooted in the human
spirit.
• Biology is the scientific extension of the human
tendency to connect to and be curious about life.
• Biology is one of the sciences takes us:
– Into a variety of environments to investigate
ecosystems
– To the laboratory to examine how organisms
work
– Into the microscopic world to explore cells and
the submicroscopic to explore molecules in cells
– Back in time to investigate the history of life.
• Biology is both – a body of knowledge &
an ongoing inquiry process to enhance it.
• This is an exciting era for exploring biology.
– The largest and best-equipped community of
scientists try to solve problems that once seemed
insolvable.
– Genetics and cell biology are revolutionizing
medicine and agriculture.
– Molecular biology provides new tools to trace the
origins and dispersal of early humans.
– Ecology is helping evaluate environmental issues.
– Neuroscience and evolutionary biology are
reshaping psychology and sociology.
 Unifying themes pervade all of
biology
• Life’s basic characteristic is a high degree
of order build with materials based on
carbon.

• Biological organization is based on a

hierarchy of structural levels, each
building on the levels below.
 Hierarchical levels of life
• Atoms
• Molecules
• Organelles
Invisible
• Cells
• Tissues & Organs
• Organisms
• Populations Visible
• Communities
• Ecosystems & Biosphere
 Atoms & Molecules
• At the lowest level are atoms of diverse
chemical elements.
• Atoms are ordered via
bonds into larger, complex
biological entities called
molecules.
• Many molecules are arranged into minute
structures called organelles, which are
crucial functional components of cells.
 Cells are the smallest living structures of
organisms; they are the living units of life.
 Some organisms consist of single cells,
others are multicellular aggregates of
specialized cells.
 Whether multicellular or
unicellular, all organisms
must accomplish the
same functions:
uptake and processing of
nutrients, excretion of wastes, response to
environmental stimuli, and reproduction among
others.
 Tissues
 Similar cells are grouped into tissues to fulfill
certain biological functions.
 In multicellular organisms several tissues
coordinate to form organs, and several organs
form an organ system.
For example, to coordinate
locomotory movements,
sensory information travels
from sense organs to the brain,
where nervous tissues composed
of billions of interconnected neurons,
supported by connective tissue,
coordinate signals that travel via
other neurons to the individual muscle cells.
 Organisms & Populations
 Biological organisms belong to larger
populations, i.e., a localized group of
organisms belonging to the same species.
 Populations of several species in the same
environment comprise a
biological community.
 These populations interact
with their physical
environment to form
an ecosystem.
 Biology: The study of life
• Investigating life at its many levels is
fundamental to biology.
• Biological processes often involve several
levels of biological organization.
– The coordinated strike of a rattlesnake at a
mouse requires complex interactions at the
molecular, cell, tissue, and organ levels within
its body.
• Many biologists study life at one level but
gain a broader perspective when integrating
discoveries with processes at other levels.
 Life & Emergent properties
• While studying life, novel properties emerge at
each step upward in the biological hierarchy.
• These emergent properties result from
interactions between components.
– A cell is certainly much more than a bag of
molecules.
• This theme of emergent properties accents the
importance of structural arrangement.
• The emergent properties of life are not
supernatural, but simply reflect a hierarchy of
structural organization.
• Life resists a simple, one-sentence definition, but we
can recognize life by what living things do; life has
defining properties.
 Is this “Fulgurite” alive?
• How do you know you deal with life?
 The properties of life
1. Complex structures
- made of chemical elements, mostly carbon (C)
2. Metabolism
- the sum of all chemical reactions
- anabolism & catabolism
3. Homeostasis
- capacity to maintain internal balance
4. Responsiveness
- living organisms are able to react to external
stimuli, e.g. light, cold, heat, with the help of
sensory mechanisms, tissues or organs
 The properties of life
5. Development & Growth
- living organisms develop from simple small
structures, e.g. spores, seeds, eggs, cells, into
more complex or multiple structures
 Properties of life
6. Reproduction
- living organisms are able to form new (daughter)
organisms and
new generations
with the help of
the hereditary
molecule DNA

7. Capacity to evolve
 The diversity of life

• Diversity is a hallmark of life.

– At present, biologists have identified and
named about 1.5 million species.
• This includes over 280,000 plants, almost 50,000
vertebrates, and over 750,000 insects.
– Thousands of newly identified species are
added each year.
• Estimates of the total diversity of life range
from about 5 million to over 30 million
species.
 Taxonomy
• Biological diversity is something to relish and
preserve, but can be a bit overwhelming.
• Despite its complexity, biologists have categorized
life into a smaller number of groups through
taxonomy.
• Taxonomy is the
branch of biology
that names and
classifies species
into a hierarchical
order.
 The diversity of life
• More than 1.5 million different species are known
• Biologists ordered - or classified – life’s huge
diversity into three domains and six major
kingdoms
The six kingdoms of life
• New methods, including comparisons of DNA
among organisms, have led to a reassessment
of the number and
boundaries of the
kingdoms.
• Below the kingdom level
biologists introduced
phyla, classes, orders,
families and genera
• At the lowest level is
the species concept
 Life: Unity in diversity
• Despite the enormous diversity there is
much unity in life.
• All life forms are made up from cells.
- prokaryotic & eukaryotic cell types exist
- cell theory postulates that all living things consist
of cells.
• The hereditary molecule
of all forms of life is DNA.
- DNA is the substance of genes,
the units of inheritance that
transmit information from parents
to offspring.
• All forms of life employ the same genetic
code made up from 64 chemical codons.
- The diversity of life is generated by different
expressions of a common chemical language
for
programming biological order.
• All life forms assure growth by performing
highly similar DNA copying and cell
division processes.
- DNA replication, mitosis (eukaryotic) & binary
fission (prokaryotic)
• All life forms use ribosomes to translate the
genetic code of genes into proteins
• All life forms use biological catalysts called
enzymes to drive their many chemical
reactions, i.e. metabolism.
• All life forms posses regulatory control
mechanisms which assure homeostasis.
- positive and negative feedback mechanisms
- negative feedback slows processes down
• All life forms exist as open systems that
exchange energy and materials with their
surrounding environment.
- leaves absorb carbon dioxide from the air, water
from the soil and capture
the energy of light to
drive photosynthesis; in
exchange oxygen is
released
- the exchange of energy
between an organism
and its surroundings
involves the transformation of energy from one
form to another while heat is released
• Strong correlation of structure and
function in life forms at all levels of
biological organization
• E.g. structure-function relationship in the
aerodynamic efficiency in shape of bird wing.
– Honeycombed internal structure produces light
but strong bones.
– Neurons control
flight muscles.
– Many mitochondria
provide the energy
to power flight.
• All life forms evolve.
• Evolution is the key to understanding
biological diversity. Evolutionary
connections among all organisms explain
the unity and diversity of life.
• Evolution is the core
theme of biology.
• It accounts for this
combination of unity
in diversity of life.
• Since life evolves, each species is one twig
on a branching tree of life extending back
through ancestral species, living and extinct.
• The history of life is a
saga of a restless
Earth billions of years
old, inhabited by a
changing cast of living
forms.
• Species that are very similar share a common
ancestor that represents a relatively recent
branch point on the tree of life.
– Brown bears and polar bears share a recent
common ancestor.
• Both bears are also related through older
common ancestors to other organisms.
– The presence of hair and milk-producing
mammary glands indicates that bears are
related to other mammals.
• Similarities in cellular structure, like cilia, indicate
a common ancestor for all eukaryotes.
• All life is connected through evolution.
• Charles Darwin brought evolutionary biology
into focus in 1859 when he presented two
main concepts in The Origin of Species.
• 1. Contemporary species
arose from a succession
of ancestors through
“descent with modification”
(evolution).
• 2. The mechanism of
evolution is natural
selection.
 The process of science
• The word science is derived from the Latin
verb ‘scientia’ meaning “to know”.
• At the heart of science are people asking
questions about nature and believing that
those questions are answerable.
• The process of science blends two types
of exploration: discovery science and
hypothetico-deductive science.
• Science seeks natural causes for natural
phenomena.
• The scope of science is limited to the study
of structures and processes that we can
observe and measure, either directly or
indirectly, e.g. through
experimentation.
• Verifiable observations
and measurements are
the data of discovery
science.
• Discovery science can lead to important
conclusions via inductive reasoning.
• An inductive conclusion is a generalization that
summarizes many concurrent observations.

• The observations of discovery science

lead to further questions and the search
for additional explanations via the
scientific method.
 Scientific inquiry process
• The scientific method consists of a series of
steps.
• Few scientists adhere
rigidly to this prescription,
but at its heart the
scientific method employs
hypothetico-deductive
reasoning.
 Role of hypothesis
• A hypothesis is a tentative answer to some
question (“proposed explanation”).
• The deductive part in hypothetico-
deductive reasoning refers to the use of
deductive logic to test hypotheses.
• Most hypothesis are tested by performing
a scientific experiment to see whether or
not the results are as predicted.
• Deductive logic takes the form of “If…then”
logic.
– Reasoning flows from general to specific.
 Experimental controls
• A “good” scientific hypothesis has to be testable
(‘verifiable’), falsifiable and based on causality.
• Scientists use controlled experiments to make
comparisons between two sets of subjects, e.g.
patients +/- drug.
– The set that receives the experimental treatment
(drug) is the experimental group.
– The control group receives all variables as the
experimental group except the control variable (=
drug).
• Controlled experiments enable scientists to
focus on responses to the change of a single
variable.
 Scientific theory
• Facts, in the form of verifiable observations
and repeatable experimental results, are the
prerequisites of science.
• Science advances when several observations
and experimental results that seemed
unrelated are tied together in a theory.
• A scientific theory is broader in scope, more
comprehensive, than a hypothesis.
– They are only widely accepted in science if they
are supported by the accumulation of extensive
and varied evidence.
• Scientific theories are not the only way of
“knowing nature”.
– Various religions present diverse legends that
tell of a supernatural creation of Earth and its
life.
– Science and religion are two very different ways
of trying to make sense of nature.
– Art is another way.
• Biology showcases life in the scientific
context of evolution, the one theme that
continues to hold biology together no matter
how big or complex the subject becomes.
• Facts, in the form of verifiable observations and
repeatable experimental results, are the
prerequisites of science.
• Science advances when:
1. A new theory ties together several observations
and experimental results that seemed unrelated
previously.
2. New technologies are applied to answer old
questions.
• A scientific theory is broader in scope, more
comprehensive, than a hypothesis.
– Both are only accepted in science if they are
supported by accumulation of extensive and
varied evidence.
• It is not unusual that several scientists are
asking the same questions using different
approaches, e.g. techniques.
– Scientists build on earlier research and pay close
attention to contemporary scientists in the same
field.
– They share information through publications,
seminars, meetings, and personal communication.
• Both cooperation and competition
characterize the scientific culture.
– Scientists check each other’s claims by attempting
to repeat experiments.
– Scientists are generally skeptics.
• Some philosophers of science argue that scientists
are so influenced by cultural and political values
that science is no more objective than other ways
of “knowing nature”.
• At the other extreme are those who view scientific
theories as though they were natural laws.
• The reality of science is somewhere in between.
• The cultural milieu affects scientific fashion, but
need for repeatability in observation and
hypothesis testing distinguishes science from other
fields.
• If there is “truth” in science, it is based on a
preponderance of the available scientific
evidence.
 Science & Technology
• Are associated and are functions of society.
• Technology results from scientific
discoveries applied to the development of
goods and services.
• DNA technology and biotechnology has
revolutionized the pharmaceutical industry.
• It also has an important impact on
agriculture and the legal profession.
– E.g. genetic engineering enables scientists to
transplant foreign genes into microorganisms
and mass-produce valuable products.
• Not all of technology is applied science.
– Technology predates science, driven by
inventive humans who designed inventions
without necessarily understanding why their
inventions worked.
– The direction that technology takes depends
less on science than it does on the needs of
humans and the values of society.
• Technology has improved our standard of
living, but also introduced new problems.
– Science can help us identify problems and
provide insight about courses of action that
prevent further damage.
• Both science and technology have become
powerful functions of society.
• It is important to distinguish “what we would
like to know” from “what we would like to
build.”
• Scientists should try to influence how
scientific discoveries are applied.
• Scientists should educate politicians,
bureaucrats, corporate leaders, and voters
about how science works and about the
potential benefits and hazards of specific
technologies.
Any Questions