Akzo Nobel Functional Chemicals LLC

MATERIAL SAFETY DATA SHEET

Dissolvine® NA2-S

1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

Product Name Dissolvine® NA2-S
Chemical Name Ethylenediaminetetraacetic acid, disodium salt, dihydrate
Synonym(s) Disodium EDTA dihydrate
Product Use Chelating agent
Manufacturer / Supplier Akzo Nobel Functional Chemicals LLC
Chelates Americas
525 West Van Buren St., Chicago, IL 60607
Tel. 1-800-906-7979
www.dissolvine.com

Emergency Telephone Numbers

CHEMICAL CHEMTREC (800) 424-9300 (Toll-free in the U.S., Canada, and the U.S. Virgin Islands)
EMERGENCY (24-hr) (703) 527-3887 (For calls originating elsewhere / collect calls are accepted)
(Spill, Leak, Fire, Exposure or
Accident) CANUTEC (613) 996-6666
(Canada)
MEDICAL / HANDLING (914) 693-6946 [AkzoNobel – USA]
EMERGENCIES

2. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
CAUTION ! Contact with dust may cause skin, eye and respiratory tract irritation.
Appearance and odor Odorless white free-flowing powder.

Fire & Explosion Although this product is not defined as flammable or combustible, potential for dust explosion
Hazards may exist. Depending upon conditions, dust may be sensitive to static discharge. Avoid
possibility of dry powder and friction causing static electricity in presence of flammable
materials (See NFPA-77, Chap.6).

POTENTIAL HEALTH EFFECTS [See Section 11 for additional information]

Primary Route(s) of Eye contact, skin contact and inhalation
Exposure
Acute Exposure
Inhalation Exposure to an excessive concentration of dust may cause respiratory tract discomfort and/or
mild irritation.
Skin Contact Disodium EDTA dihydrate was moderately irritating to rabbit skin, causing reversible effects
such as redness, slight edema, scabbing and scarring after repeated application.
Eye Contact Eye contact with dust may cause mild physical irritation.
Ingestion This product is expected to have a low order of acute toxicity.
Carcinogenicity IARC, NTP, ACGIH and OSHA do not classify this material as a carcinogen or suspect
carcinogen.
EDTA and its sodium salts caused birth defects in some animal studies in the presence of
Reproduction
maternal toxicity
Medical Conditions There are no data available that address medical conditions that are generally recognized as
Aggravated by Exposure being aggravated by exposure to this product.

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2. HAZARDS IDENTIFICATION (CONTINUED)

POTENTIAL ENVIRONMENTAL EFFECTS [See Section 12 for additional information]
Aquatic Toxicity This product is not expected to be harmful to aquatic life, based on available data.

3. COMPOSITION / INFORMATION ON INGREDIENTS

INGREDIENTS CAS Number % (w/w)
EDTA disodium salt 139-33-3 89 – 91
Water 7732-18-5 9 – 11

4. FIRST AID MEASURES

Inhalation Dust may be irritating to the respiratory tract and cause symptoms of bronchitis. Remove victim
to fresh air. If irritation occurs or if breathing becomes difficult, get medical attention.
Skin Contact Remove contaminated clothing, shoes and equipment. Wash all affected areas with soap and
plenty of water. Wash contaminated clothing and shoes before reuse. Get medical attention if
irritation occurs or persists.
Eye Contact Flush eyes with large quantities of running water for a minimum of 15 minutes. If the victim is
wearing contact lenses, remove them. Hold the eyelids apart during the flushing to ensure
rinsing of the entire surface of the eye and lids with water. Do not let victim rub eye(s). Do not
attempt to neutralize with chemical agents. Get medical attention if eye irritation occurs.
Ingestion Give several glasses of water. DO NOT induce vomiting. If vomiting occurs, keep head below
hips to reduce risk of aspiration. Give fluids again. Never give anything by mouth to a person
who is unconscious or convulsing. Get medical attention if health effects occur.
Note to Physician Attending physician should treat exposed patients symptomatically.

5. FIRE FIGHTING MEASURES

Flammable Properties not flammable or combustible
Extinguishing Media Use water fog or spray, dry chemical, foam or carbon dioxide extinguishing agents.
Fire Fighting Procedures As in any fire, prevent human exposure to fire, smoke, fumes or products of combustion.
Evacuate all non-essential personnel from the fire area. Fire fighters should wear full-face,
self-contained breathing apparatus and impervious protective clothing.
Fire & Explosion Although this product is not defined as flammable or combustible, potential for dust explosion
Hazards may exist. Depending upon conditions, dust may be sensitive to static discharge. Avoid
possibility of dry powder and friction causing static electricity in presence of flammable
materials (See NFPA-77, Chap.6).
Hazardous Combustion Thermal decomposition products may release toxic and/or hazardous fumes and gases,
Products including nitrogen oxides and carbon oxides.
NFPA Hazard Rating Health: 1 / Fire: 1 / Instability: 0 / Other: None
[0 – Minimal / 1 – Slight / 2 – Moderate / 3 – High / 4 – Extreme]

6. ACCIDENTAL RELEASE MEASURES

Personal Precautions All personnel involved in spill cleanup should avoid skin and eye contact by wearing
appropriate personal protective equipment.
Methods for Safely stop source of spill. Restrict non-essential personnel from area.
Containment

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6. ACCIDENTAL RELEASE MEASURES

Environmental Sweep up spilled solid material, being careful not to create dust. Return sweepings to stock or,
Precautions if contaminated, place into a chemical waste container for disposal. Flush remainder with
water.
Methods for Clean-up Using a stiff brush, work the slurry into cracks and crevices. Allow to stand for 2-3 minutes.
Then flush again with water. Repeat if necessary. Dike water for later disposal. Do not allow
contaminated water to enter waterways. CAUTION – The spill area may be slippery.
Other Information See also Section 13 for disposal information.

7. HANDLING AND STORAGE

Handling Avoid inhalation of dust as well as prolonged and/or repeated skin and eye contact.
Storage Keep containers closed and dry. This material is suitable for any general chemical storage
area. Store in PVC, PE, stainless steel or bituminized tanks. Avoid contact with aluminum,
copper, copper alloys, nickel and zinc.

Recommended Storage Store in a cool and dry place at ambient temperature (below 25°C / 77°F).
Temperature
General Comments Containers should not be opened until ready for use. Opened containers must be closed again
properly. It is advised to re-test the product after three years of storage. In certain
concentrations, the product may form an explosive dust-air mixture. Protect product from
moisture and wet air.

8. EXPOSURE CONTROLS / PERSONAL PROTECTION

Exposure Guidelines
OSHA – PELs ACGIH – TLVs NIOSH – RELs AIHA – WEELs
(mg / m3) (mg / m3) (mg / m3) (mg / m3)
Chemical Name
STEL / STEL / STEL / STEL /
TWA TWA TWA TWA
CEIL(C) CEIL(C) CEIL(C) CEIL(C)
EDTA, disodium salt N/D N/D N/D N/D N/D N/D N/D N/D
Water N/D N/D N/D N/D N/D N/D N/D N/D
[Ref: ACGIH Guide to Occupational Exposure Values, 2008 Edition]

Legend:
CEIL: Ceiling Exposure Limit PEL: Permissible Exposure Limit REL: Recommended Exposure Limit
STEL: Short Term Exposure Limit TLV: Threshold Limit Value TWA: Time-Weighted Average
N/D: Not Determined WEEL: Workplace Environmental Exposure Level
ACGIH: American Conference of Governmental Industrial Hygienists
AIHA: American Industrial Hygiene Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration

Engineering Controls Special ventilation is usually not required under normal use conditions. Ensure that existing
& Ventilation ventilation is sufficient to prevent the circulation and/or accumulation of dust in the air.
Personal Protective Equipment (PPE)

Respiratory Use of respiratory protection is generally not required. However, if use conditions generate dust
and adequate ventilation (e.g., outdoor or well-ventilated area) is not available, use a NIOSH-
approved organic vapor respirator with dust, mist and fume filters to reduce potential for
inhalation exposure. When using respirator cartridges or canisters, they must be changed
frequently (following each use or at the end of the work shift) to assure breakthrough exposure
does not occur.

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Akzo Nobel Functional Chemicals LLC Dissolvine® NA2-S

8. EXPOSURE CONTROLS / PERSONAL PROTECTION (CONTINUED)

Skin Skin contact with the product should be minimized or prevented through the use of suitable
protective clothing, gloves and footwear selected according to use condition exposure potential.
For permanent (>8 hours) full contact use, 100% Viton gloves are recommended.
Eyes/Face Since eye contact with dust may cause irritation, chemical goggles and/or a face shield should
be worn when handling this product.
Hygiene Measures All food and smoking materials should be kept in a separate area away from the storage/use
location. Eating, drinking and smoking should be prohibited in areas where there is a potential
for significant exposure to this material. Before eating, drinking and smoking, hands and face
should be thoroughly washed.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance
Form powder
Color white
Odor odorless
Boiling Point not applicable
3
Bulk Density ~ 700 kg/m
Evaporation Rate not determined
(Butyl Acetate=1)
Melting Point 110°C (230°F) / loss of crystallization
Odor Threshold not determined
pH ~ 4.0 – 6.0 (5% solution)
Partition Coefficient Log Pow < 0
(n-octanol/water)
Solubility in Water ~ 100 mg/L (at 20°C / 68°F)
Solubility in Other not determined
Solvents
Specific Gravity not determined
Vapor Density (Air = 1) not applicable
Vapor Pressure not applicable
Viscosity not applicable
Volatiles (% by weight) not determined
Other decomposition temperature = 255°C (491°F)
Flammability not flammable or combustible
Flash Point (Method) not applicable
Upper Flammable Limit not applicable
(% by volume)

Lower Flammable Limit not applicable

(% by volume)

Auto-Ignition not applicable

Temperature
< : less than > : greater than ≈ : approximately

10. STABILITY AND REACTIVITY

Chemical Stability This product is stable under recommended storage and handling conditions (see section 7). It
is not self-reactive and is not sensitive to physical impact.
Conditions to Avoid Avoid contact with aluminum, nickel, zinc, copper and copper alloys in combination with
humidity/water (formation of hydrogen). Avoid prolonged storage at elevated temperatures.
Incompatible Materials This product is incompatible with strong oxidizers.

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10. STABILITY AND REACTIVITY (CONTINUED)

Hazardous Under fire conditions the product may support combustion and decomposes to give off carbon
Decomposition Products oxides fumes (CO, CO2) and nitrogen oxides.
Possibility of Hazardous Hazardous polymerization is not expected to occur under normal temperatures and pressures.
Reactions

11. TOXICOLOGICAL INFORMATION

Inhalation - Acute The acute LC50 for this product is not available. There were no mortalities when rats were
exposed to a saturated dust atmosphere (nominal concentration of 1.13 mg/L) for 7 hours.
Exposure to an excessive concentration of dust may cause respiratory tract discomfort and/or
mild irritation.
Inhalation - Chronic No known effects for this product.
Skin - Acute Dermal toxicity for this product is not available. A 4-hour human exposure to 0.2 g of 99% pure
Disodium EDTA showed no irritation. Disodium EDTA dihydrate was moderately irritating to
rabbit skin causing reversible effects such as redness, slight edema, scabbing and scarring
after repeated application.
Skin - Chronic No known effects for this product.
Eyes This product is slightly irritating to rabbit eyes.

Ingestion - Acute The oral LD50 is greater than 2,000 mg/kg (rat).
Ingestion - Chronic Disodium EDTA was administered in the feed of male rats for 4 weeks and female rats for 31
days. There were no adverse effects at the lowest tested dose of 692 mg/kg/day for male rats
and 237 mg/kg/day for female rats (NOAEL). As well, in a 2-year study, rats were fed diets
containing 0.5, 1 or 5% Disodium EDTA. There were no mortalities attributed to the treatment.
Sensitization No known effects for this product.
Carcinogenicity IARC, NTP, ACGIH and OSHA do not classify this material as a carcinogen or suspect
carcinogen.
Mutagenicity Disodium EDTA dihydrate gave negative results in numerous tests (such as Ames Assay,
Mouse Lymphoma Assay, Micronucleus Assay). Disodium EDTA dihydrate did induce a dose-
dependent increase in chromosome aberrations in CHL fibroblast cells with metabolic
activation.
Reproductive Toxicity EDTA and its sodium salts have been reported, in some studies, to cause birth defects in
laboratory animals only at exaggerated doses that were toxic to the mother. These effects are
likely associated with zinc deficiency due to chelation. Exposures having no effect on the
mother should have no effect on the fetus. Disodium EDTA had no effect on mouse sperm
morphology.
Other Effects None known.
Target Organs Eyes, skin and developmental (in the presence of maternal toxicity).

12. ECOLOGICAL INFORMATION

Ecotoxicity No data available for this product. However, the following information is available for a
structurally related product:

Test Exposure / Duration Test Results

Algae (green algae) 96-h EC50 = 1.14E8 mg/L (calculated by EPIWIN model)
Fish (guppy) 96-h LC50 = 320 mg/L
Bacteria (Pseudomonas putida) 8-h EC50 = 56 mg/L

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Akzo Nobel Functional Chemicals LLC Dissolvine® NA2-S

12. ECOLOGICAL INFORMATION (CONTINUED)

Biodegradation This product is not readily biodegradable (based on tests with structurally related products).
Bioaccumulation It is not expected to bioaccumulate. The calculated Log Pow is – 11.7 (EPIWIN/KOWWIN
models).
Other Ecotoxicity Disodium EDTA did not undergo photodegradation under laboratory conditions.
information

13. DISPOSAL CONSIDERATIONS

Waste Disposal In its unused condition, this product is not considered to be a RCRA-defined hazardous waste
by characteristics or listings. It is the responsibility of the waste generator to evaluate whether
his wastes are hazardous by characteristic or listing. Dispose in accordance with all local, state
and federal regulations. NOTE – State and local regulations may be more stringent than
federal regulations.
Container Disposal Containers should be cleaned of residual product before disposal or return. Since emptied
containers retain product residue, follow label warnings even after container is emptied. Empty
containers should be disposed of or shipped in accordance with all applicable laws and
regulations.

14. TRANSPORT INFORMATION

Regulatory UN
Proper Shipping Name Class PG Label Additional Information
Information Number
US DOT
TDG – Canada Not regulated for transport.
N/R N/R N/R N/R N/R
IMDG
IATA/ICAO
Emergency Response Not applicable
Guidebook (2008 ERG)
Environmentally None known
Hazardous Substances
[49 CFR 172.101, Appendix A]

15. REGULATORY INFORMATION

Regulatory Lists / Inventories: The components are subject to the following regulatory lists and inventories:

US STATE RIGHT-TO- CA
Substance Name CAA CERCLA IARC SARA
KNOW LISTS PROP 65
EDTA, disodium salt N/R N/R N/R N/R N/R N/R

Water N/R N/R N/R N/R N/R N/R

National Chemical Inventories Status:

Canada New
Substance US EU Australia Japan Korea Philippines China
Zealand
Name TSCA DSL NDSL EINECS AICS ENCS KECI PICCS IECSC
NZIoC
EDTA, disodium
X X X X X X X X X
salt
Water X X X X X X X X X

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15. REGULATORY INFORMATION (CONTINUED)

Legend
AICS Australian Inventory of Chemical Substances
CA LIST California – Directors List of Hazardous Substances
CA PROP 65 California Proposition 65
CAA Clean Air Act, Section 112
CERCLA CERCLA Hazardous Substances
DSL Domestic Substances List – Canada
EINECS European Inventory of Existing Commercial Chemical Substances
ENCS Japan Existing and New Chemical Substances
FL LIST Florida – Substance List
IARC International Agency for Research on Cancer – Carcinogens – Groups 1, 2A or 2B
IECSC China – Inventory of Existing Chemical Substances
IL LIST Illinois Toxic Substances Disclosure to Employees Act
KECI Korea Existing Chemicals Inventory
LA LIST Louisiana Right-to-Know Reporting List
MA LIST Massachusetts – R-T-K Substance List
MN LIST Minnesota – Hazardous Substance List
NDSL Non-Domestic Substances List – Canada
NJ R-T-K New Jersey – R-T-K Hazard List
N/R Non Regulated
NZIoC New Zealand Inventory of Chemicals
PA LIST Pennsylvania Hazardous Substance List
PICCS Philippines Inventory of Chemicals and Chemical Substances
RI LIST Rhode Island – Hazardous Substance List
SARA SARA Title III, Section 302 / 313
TSCA Toxic Substances Control Act – USA
X Listed and/or Regulated

CANADA – WHMIS (Workplace Hazardous Materials Information System)

Not controlled This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and
the MSDS contains all the information required by the CPR.

Other Regulatory The Cosmetic Ingredient Review (CIR) Expert Panel determined that EDTA and its salts are
Information safe as used in cosmetic formulations.

16. OTHER INFORMATION

HMIS RATING Health: 1 / Flammability: 1 / Physical Hazard: 0 / Other: none
[ 0 – Minimal / 1 – Slight / 2 – Moderate / 3 – High / 4 – Extreme / * - Chronic Health Hazard (see Section 11)]

Trademark Dissolvine® is a registered trademark of Akzo Nobel Chemicals B.V.

Date of Issue / Revision November 24, 2008
Revision # 10.0
Changes Section 16 / Logo
Prepared by AkzoNobel [Technology & Engineering, SHERA - Regulatory Toxicology]
Tel. 613.273.8095

Disclaimer The information in this Material Safety Data Sheet should be provided to all who will use, handle, store, transport or
otherwise be exposed to this product. Akzo Nobel Functional Chemicals LLC makes no warranty, express or implied as to
the product's merchantability or fitness for any particular purpose, or that any suggested use will not infringe any patent.
Nothing contained herein shall be construed as granting or extending any license under any patent. Buyer shall determine
for himself, by preliminary tests or otherwise, the suitability of this product for his purposes, including mixing with other
products. The information contained herein supersedes all previously issued bulletins on the subject matter covered. If the
date of this document is more than three years old, please call to ensure that this sheet is current.

[00707_061108]

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