TOLENTINI, EDJEY OMBID

BSMT2B

Week 9 Activity

Blood and Hemopoiesis

Objectives

Materials needed:

● Coloring materials

● Microscope

● Prepared slides

Procedure:

1. Find/search on the internet for a histologic image of the different formed elements in the

blood, and draw/illustrate each of them.

1. Below the

images, describe

their histologic

morphology.

Identify also their

function in the

body. it must be in

bullet form.
Neutrophils
 Neutrophils make up roughly half of the white blood cell population.
 Are usually the first cells of the immune system to respond to an invader such as a bacteria
or a virus
 They also send out signals alerting other cells in the immune system to respond to the scene.

Eosinophils
Eosinophils also play a role in fighting off bacteria and are very important in responding to
infections with parasites (such as worms). They are perhaps best known for their role in
producing allergy symptoms when they go overboard in mounting an immune response against
something (like pollen) which is mistakenly believed to be an invader.

These cells account for no more than 5% of the white blood cells in your bloodstream but are
present in high concentrations in the digestive tract.2

Basophils
Basophils, accounting for only around 1% of white blood cells, are important in mounting a non-
specific immune response to pathogens. These cells are perhaps best known for their role in
asthma.

When stimulated these cells release histamine among other chemicals. The products can result in
inflammation and bronchoconstriction in the airways.3

Lymphocytes (B and T)
Lymphocytes are also very important in the immune system, with T cells being responsible for
directly killing many foreign invaders. B lymphocytes (B cells), in contrast to the other types of
white blood cells, are responsible for humoral immunity (in contrast to the non-specific
immunity of other white blood cells).

They produce the antibodies that "remember" an infection and stand ready in case your body
should be exposed.4 B lymphocytes play the main role in the efficacy of the majority of the
current vaccines but in some cases (i.e. tuberculosis and pertussis vaccines). T lymphocytes are
also very important.

Monocytes
Monocytes are the garbage trucks of the immune system. Around 5% to 12% of white blood
cells in your bloodstream are monocytes, but their most important function is to migrate into
tissues and clean up dead cells (among other functions.)

2. Draw a diagram of each hemopoiesis of formed elements in the blood.

include the histologic feature that differentiates them from the other maturation series.

Case study:
A 35-year-old woman’s physician orders laboratory blood tests. Her fresh blood is
drawn and centrifuged in the presence of heparin as an anticoagulant to obtain a
hematocrit. From top to bottom, the fractions resulting from centrifugation are which of
the following?
a. Serum, packed erythrocytes, and leukocytes
b. Leukocytes, erythrocytes, and serum proteins
c. Plasma, buffy coat, and packed erythrocytes
d. Fibrinogen, platelets, buffy coat, and erythrocytes
e. Albumin, plasma lipoproteins, and erythrocytes
Explain your answer

C – Because the blood contains different substances which are merely the
same in mass so with gravitational force doesn’t get settled.

A hematologist diagnoses a 34-year-old woman with idiopathic thrombocytic purpura

C- Because the ITP can care excessive bruising and bleeding. it showed
anusual low level of platelets of thrombocytes in the blood that results in
ITP.

A 54-year-old man presents with recurrent breathlessness and chronic fatigue. After
routine tests followed by a bone marrow biopsy he is diagnosed with lymphocytic
leukemia. Chemotherapy is administered to remove the cancerous cells, which also
destroys the precursor cells of erythrocytes. To reestablish the erythrocytic lineage,
which of the following cells should be transplanted?
a. Reticulocytes
b. Orthochromatophilic erythroblasts
c. Megakaryoblasts
d. Basophilic erythroblasts
e. Metamyelocytes
Explain your answer

D- Because basophilc erythroblast a nucleated precursor in the

A smear of blood from a 70-year-old leukemia patient reveals a larger than normal
population of cells that have large, round nuclei with one or two nucleoli. The cytoplasm
of these cells shows azurophilic granules. Which of the following forms of leukemia
would you suspect?
a. Promyelocytic leukemia
b. Basophilic leukemia
c. Lymphoblastic leukemia
d. Stem cell leukemia
e. Eosinophilic leukemia
Explain your answer

E- Because eosinophil is a specialized cell of the immune system. Aside